CN110075215A - A kind of preparation method and purposes of compound Polygonatum combined extracts - Google Patents
A kind of preparation method and purposes of compound Polygonatum combined extracts Download PDFInfo
- Publication number
- CN110075215A CN110075215A CN201910407842.1A CN201910407842A CN110075215A CN 110075215 A CN110075215 A CN 110075215A CN 201910407842 A CN201910407842 A CN 201910407842A CN 110075215 A CN110075215 A CN 110075215A
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- China
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- ginseng
- jujube
- filter residue
- fructus lycii
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Classifications
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- C—CHEMISTRY; METALLURGY
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- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G1/00—Preparation of wine or sparkling wine
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- C—CHEMISTRY; METALLURGY
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- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G3/00—Preparation of other alcoholic beverages
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Abstract
The present invention relates to Chinese medicine manufacture field and functional food manufacture fields, and in particular to a kind of preparation method and purposes of compound Polygonatum combined extracts.A kind of preparation method of compound Polygonatum combined extracts of the present invention, it is characterized in that being made by Chinese medicine material the rhizoma polygonati 9-15, ginseng 3-9, fructus lycii 6-12, mulberry fruit 9-15, jujube 6-15 of following parts by weight and with the cyclodextrin of the parts by weight such as Chinese medicine material.Routinely granule, tablet, capsule, pill, oral solution is made compound Polygonatum combined extracts of the invention as the purposes for preparing functional food or wine product in technique.
Description
Technical field
The present invention relates to Chinese medicine manufacture fields, further relate to functional food manufacture field, and in particular to a kind of compound Polygonatum
The preparation method and purposes of combined extracts.
Background technique
Since 40 years, China has all obtained significant progress, the living standard of the people in the various aspects of society
Significant raising is obtained.At the same time, as industrial development, population increase it is too fast and caused by living environment deteriorate, air
Aggravate with water resource pollution, work, stress is big and reasons, China residents such as diet collocation is not scientific suffer from various diseases
Ratio and unhealthy crowd rise year by year.The progress of diet largely indicates a national overall qualities and society
It can development level.The cooking culture of China once made significant contribution to world's diet the reach of science, especially in diet
The achievement more world acquired by health, dietotherapeutic food resource use aspects is promoted to be attracted attention.But due to modern age it is economical,
The development in the fields such as culture and science and technology relatively lags behind, China's modern diet scientific level, especially simultaneous to traditional medicine food
Scientific knowledge and reasonable use aspects with functional component in resource, have fallen in behind some developed countries.Since 40 years,
With the rapid raising of China's socio-economic development level, it is some in the past less reasonable that the people has begun attention change
Eating habit, " science eaten, health living, living is permanent " have become the generally pursuit of people.The increase of national income and
The raising of the level of consumption, and people is made to have stronger consuming capacity, it is sufficient to pay wholesome functional food relatively
High spending.It is all these all to constitute the very strong driving force of current functional food Industry Quick Development.But for a period of time,
Domestic some healthy food manufacturing enterprises utilize approval of the people to dietotherapeutic resource, develop the raw material group of some dietotherapeutics
It closes, using tea or tea bag as marketing, tea product such as is made in rhizoma polygonati, ginseng, fructus lycii, mulberry fruit, jujube, due to these productions
The factors such as product are drunk to people to be brought it to steep drink method cannot to unify, and Ganderwa is uncertain, cause the unreasonable of its dosage and
It does not know and cannot achieve ideal application effect, consumer is finally made to produce trust crisis to functional food class product,
Functional food production and processing industry receives injury.For this purpose, being carried out to traditional dietotherapeutic utilization of resources modern science technique
Deep processing makes its effective component obtain rationally sufficiently extracting, and can become especially to weigh to its usage, dosage accurate positionin to its product
It wants.
The present invention using rhizoma polygonati, ginseng, fructus lycii, mulberry fruit, jujube Chinese traditional medicine composition method for preparing extractive, through retrieving,
There is not yet relevant report and related patent application.
Summary of the invention
The object of the present invention is to provide a kind of preparation methods of compound Polygonatum combined extracts.
It is used as the object of the invention is also to provide a kind of compound Polygonatum combined extracts and is prepared into functional food or wine
Purposes in product.
The preparation method of a kind of compound Polygonatum combined extracts provided by the invention, which is characterized in that it is by following heavy
Measure part Chinese medicine material rhizoma polygonati 9-15, ginseng 3-9, fructus lycii 6-12, mulberry fruit 9-15, jujube 6-15 and with the weight such as Chinese medicine material
The cyclodextrin of part is made,
Specifically the preparation method is as follows: (1) first respectively dries Chinese medicine rhizoma polygonati, ginseng, fructus lycii, mulberry fruit, jujube, so
Rhizoma polygonati, ginseng, fructus lycii after weighing drying afterwards, mulberry fruit, that jujube pulverizes into 10 mesh powder respectively is spare；(2) ginseng pulverate is pressed into medicine
Material total weight ratio is the alcohol that 1:3 is added that concentration is 99%v/v, is impregnated 12 days under normal temperature state, during immersion daily sufficiently
Stirring 1 time, after immersion, leaching alcohol soak is saved backup, and filter residue is spare；(3) by rhizoma polygonati, fructus lycii, mulberry fruit, jujube
After all medicinal powder mixing are added water immersion 4 hours that medicinal material total weight ratio is 1:10, the filter residue in step (2) is added, heating
It boils 2 hours, the another device of leaching decoction liquor saves, and the water that medicinal material total weight ratio is 1:8 is added in filter residue, adds boiling to boil 1 hour, filter
The another device of decoction liquor is taken to save, filter residue adds the water that medicinal material total weight ratio is 1:5, and boiling is added to boil 0.5 hour, and leaching decocts
Liquid discards filter residue；(4) by decoction liquor merging three times in step (3), 150 meshes are crossed, it is concentrated to obtain concentrate to specific gravity for 5.0
It is spare；(5) alcohol soak obtained by step (2) is merged with concentrate obtained by step (4), ring paste is added by medicinal material total weight parts
Essence is placed in ball mill and be fully ground 3 hours, after grinding, takes out material, is dried to water content < 6%w/w,
It pulverizes, crosses 80 meshes to get compound Polygonatum combined extracts.
Present invention cyclodextrin (CYD) described above, can be beta-cyclodextrin (β-CYD), is also possible to 2,6- dimethyl-
Beta-cyclodextrin (DM- β -- CYD), hydroxyethyl-β-cyclodextrin (HE- β-CYD), hydroxypropyl-β-cyclodextrin (HP- β-CYD) and sulphur fourth
Any one in base ether-beta-cyclodextrin (SBE- β-CYD).
CYD is safe and non-toxic, pertinent regulations (the FAQ nutrition meeting according to the World Health Organization to food additives
NO46WHO/FOOD ADD/70.36), the starch of enzymology feature no longer needs to do toxicity research；Many experimental studies also turn out β-
CYD tool shows its LD of Mouse oral in very high safety, acute toxicity test50> 300 mg/kg, acute toxicity and chronic toxicity
Test, carcinogenic, mutagenicity test of teratogenesis etc. demonstrate this product using safe and non-toxic.The U.S., Japan pharmacopeia oneself B-CYD is recorded
To take orally auxiliary material: HP-B-CYD(hydroxypropyl-B- cyclodextrin) " the Handboofk of that has been write by United States Pharmacopeia and Wade A
Pharrnaceutical Excipients " record for injection supplementary material (Zhao Jie is such as edited, modern Chinese herbal medicine new agent technology,
Jiangsu science tech publishing house, 2 months 2007 the 1st edition, page 151).
Heretofore described alcohol refers both to be food grade alcohol when not providing certain illustrated.
Heretofore described water is pure water when not having certain illustrated.
Present invention drying described above, for using vacuum drying, vacuum drying condition is temperature 50 C, vacuum degree
For 0.2kPa.
The preparation method of currently preferred a kind of compound Polygonatum combined extracts, it is characterized in that by following parts by weight
Medicine raw material rhizoma polygonati 10-12, ginseng 5-7, fructus lycii 8-10, mulberry fruit 10-12, jujube 8-12 and ring with the parts by weight such as Chinese medicine material
Dextrin is made,
Specifically the preparation method is as follows: (1) first respectively dries Chinese medicine rhizoma polygonati, ginseng, fructus lycii, mulberry fruit, jujube, so
Rhizoma polygonati, ginseng, fructus lycii after weighing drying afterwards, mulberry fruit, that jujube pulverizes into 10 mesh powder respectively is spare；(2) ginseng pulverate is pressed into medicine
Material total weight ratio is the alcohol that 1:3 is added that concentration is 99%v/v, is impregnated 12 days under normal temperature state, during immersion daily sufficiently
Stirring 1 time, after immersion, leaching alcohol soak is saved backup, and filter residue is spare；(3) by rhizoma polygonati, fructus lycii, mulberry fruit, jujube
After all medicinal powder mixing are added water immersion 4 hours that medicinal material total weight ratio is 1:10, the filter residue in step (2) is added, heating
It boils 2 hours, the another device of leaching decoction liquor saves, and the water that medicinal material total weight ratio is 1:8 is added in filter residue, adds boiling to boil 1 hour, filter
The another device of decoction liquor is taken to save, filter residue adds the water that medicinal material total weight ratio is 1:5, and boiling is added to boil 0.5 hour, and leaching decocts
Liquid discards filter residue；(4) by decoction liquor merging three times in step (3), 150 meshes are crossed, it is concentrated to obtain concentrate to specific gravity for 5.0
It is spare；(5) alcohol soak obtained by step (2) is merged with concentrate obtained by step (4), ring paste is added by medicinal material total weight parts
Essence is placed in ball mill and be fully ground 3 hours, after grinding, takes out material, is dried to water content < 6%w/w,
It pulverizes, crosses 80 meshes to get compound Polygonatum combined extracts.
A kind of preparation method of the further preferred compound Polygonatum combined extracts of the present invention, feature is by following parts by weight
Chinese medicine material rhizoma polygonati 11, ginseng 6, fructus lycii 9, mulberry fruit 11 jujube 10 and is made with the cyclodextrin of the parts by weight such as Chinese medicine material,
Preparation method is as follows: (1) first respectively drying Chinese medicine rhizoma polygonati, ginseng, fructus lycii, mulberry fruit, jujube, then
Rhizoma polygonati, ginseng, fructus lycii after weighing drying, mulberry fruit, that jujube pulverizes into 10 mesh powder respectively is spare；(2) ginseng pulverate is pressed into medicinal material
Total weight ratio is the alcohol that 1:3 is added that concentration is 99%v/v, impregnates 12 days under normal temperature state, sufficiently stirs daily during immersion
It mixes 1 time, after immersion, leaching alcohol soak saves backup, and filter residue is spare；(3) rhizoma polygonati, fructus lycii, mulberry fruit, jujube is all
After medicinal powder mixing is added water immersion 4 hours that medicinal material total weight ratio is 1:10, the filter residue in step (2) is added, heating is boiled
Boiling 2 hours, the another device of leaching decoction liquor save, and the water that medicinal material total weight ratio is 1:8 is added in filter residue, add boiling to boil 1 hour, leaching
The another device of decoction liquor saves, and filter residue adds the water that medicinal material total weight ratio is 1:5, and boiling is added to boil 0.5 hour, leaching decoction liquor,
Discard filter residue；(4) by step (3) three times decoction liquor merge, cross 150 meshes, it is concentrated to specific gravity be 5.0 concentrate it is standby
With；(5) alcohol soak obtained by step (2) is merged with concentrate obtained by step (4), ring paste is added by medicinal material total weight parts
Essence is placed in ball mill and be fully ground 3 hours, after grinding, takes out material, is dried to water content < 6%w/w,
It pulverizes, crosses 80 meshes to get compound Polygonatum combined extracts.
Compound Polygonatum combined extracts of the present invention routinely technique be made granule, tablet, capsule, pill or
Oral solution is as the purposes for preparing functional food.
Present invention compound Polygonatum combined extracts described above are as the purposes for preparing wine product.
Rhizoma polygonati is liliaceous plant polygonatum kingianurn Polygonatum kingianumColl.et Hemsl., rhizoma polygonati
The dry rhizome of Polygonatum sibiricum Red. or polygonatum cyrtonema Polygonatum cyrtonema Hua.
Rhizoma polygonati nature and flavor sweet and neutral.Returns spleen, lung, kidney channel.Have boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney benefiting functions.For taste gas
Void, fatigue and asthenia, deficiency of stomach-Yin, dry deficiency of food, deficiency syndrome of the lung cough caused by dryness, overstrain cough hemoptysis, asthenia of essence and blood, soreness and weakness of waist and knees, poliosis are interior
Heat quench one's thirst (Chinese Pharmacopoeia Commission compile the Pharmacopoeia of the People's Republic of China clinical application notice prepared slices of Chinese crude drugs volume, 2015
Version, page 1227).
Utility analysis: rhizoma polygonati is sweet in flavor mild-natured, owner's the spleen channel, can nourish spleen yin and invigoration spleen qi, is that treatment taste are empty
It is weak, fatigue and asthenia, the good medicine of dry deficiency of food, therefore " Mingyi Bielu " says that its " tonifying middle-Jiao and Qi ", " book on Chinese herbal medicine is just read " " this flavour of a drug is sweet such as title
Maltosemalt sugar, the flat profit of property, is the certified products of nourished spleen Yin ".Rhizoma polygonati is in sweet flavor mild-natured, enters lung channel, not only tonifying lung yin, but also simultaneous energy QI invigorating, for treatment
The good merchantable brand of the deficiency syndrome of the lung, impairment of yin cough caused by dryness, deficiency syndrome of the lung overstrain cough hemoptysis and the deficiency syndrome of the lung, which are breathed with cough, can be selected.Rhizoma polygonati enters kidney channel, is longer than enriching yin, and and benefit
Gas, by flat tonifying spleen lung kidney can the raw marrow of replenishing essence, it is strong to consolidate, be usually used in treating asthenia of essence and blood, soreness and weakness of waist and knees, poliosis,
Heat Diabetes.
Rhizoma polygonati matches fructus lycii, and rhizoma polygonati is longer than nourishing Yin and moistening lung, and fructus lycii is good at nourishing kidney and replenishing pneuma.Two medicine compatibilities, can enhance qi-restoratives
And strengthening the essence gas, the effect of moistening lung and cough-relieving, be suitable for lung deficiency of the kidney it is empty caused by the soreness of waist pass out semen, (Chinese Pharmacopoeia Commission compiles for cough etc.
Pharmacopoeia of the People's Republic of China dispensing information prepared slices of Chinese crude drugs volume, version in 2015, page 1227).
Compendium of Material Medica " mends all void, only fever and chills, replenishing essence marrow." " new compilation of materia medica " " flat to fill blood and moisten."
Ginseng is the dry root and rhizome of Araliaceae ginseng Panax ginseng C. A. Mey..
Ginseng nature and flavor are sweet, slight bitter, tepor, returns spleen, lung, the heart, kidney channel.Have replenish vital energy, restore pulse, and strengthen and remove vital energy, reinforces the spleen to benefit the lung, it is raw
Saliva blood-nourishing, tranquilize the mind and promote the intelligence function.It to be taken off for physically weak, cold weak pulse of limb, spleen eating less, the deficiency syndrome of the lung is breathed with cough, injury thirst, and interior heat disappears
Yearningly, deficiency of qi and blood, prolonged illness void is thin, insomnia of palpitating with fear, and (Pharmacopoeia of the People's Republic of China is compiled to impotence palace cold by Chinese Pharmacopoeia Commission
Clinical application notice prepared slices of Chinese crude drugs volume, version in 2015, page 1079).
Utility analysis: ginseng is sweet in flavor, slight bitter and slightly warm in nature, main returns spleen, lung, the heart, kidney channel.Its tonifying Qi range is wide, Ji Neng great
Tonifying primordial Qi, but can tonifying lung gas, enriching spleen-QI, bushing gas and kidney tonifying gas, reinforce vital energy, the function of veins takes off admittedly without medicine can generation, to save
It endangers emergency treatment of collapse key medicine, is most suitable for because of profuse sweating, spits greatly, rush down greatly, vigour fictitious pole caused by big blood loss or serious disease, prolonged illness etc. is intended to take off, weak pulse desire
Syndrome of endangering again is waited absolutely, therefore " Sheng Nong's herbal classic is dredged " calls its " it is exhausted in hanging down to return yang-energy, empty evil in a moment ".Meanwhile traditional Chinese medicine is recognized
It is human life activity's motive power for vigour, vigour virtual loss necessarily causes the viscera functions such as lung spleen heart kidney low, occurs corresponding
Deficiency of vital energy performance, the function of reinforcing vital energy of ginseng also indirectly have the function that tonifying lung spleen heart kidney qi, therefore, the tonifying lung gas of ginseng,
The existing direct effect of the effect of enriching spleen-QI, bushing gas and kidney tonifying gas, and have indirectly-acting.Old friend's ginseng is longer than tonifying lung gas, temper, is apt to
In bushing gas, moreover it is possible to kidney tonifying gas has preferable therapeutic effect for Lung Qi deficiency, Spleen-Qi Deficiency, the heart qi deficiency and kidney qi deficiency, therefore " originally
Careless detailed outline " call its " controlling all asthenic symptoms of male woman ".
Ginseng can reinforce vital energy to support congenital and strengthening the spleen and replenishing qi to train the day after tomorrow, and sweet temperature enters spleen, energy " middle regulating and qi tonifying "
(Materia Medica of Decoction), " invigorating spleen " (" collected statements on the herbal foundation ") are tonifying spleen key medicine；All improper diet and overtirednesses, damp pathogen obstruction the spleen are worried beyond measure,
The card of caused spleen deficiency, available this product add taste application.Ginseng " specially entering lung " (" book on Chinese herbal medicine is looked for the truth "), " gas in energy tonifying lung " (" book on Chinese herbal medicine
Detailed outline "), " Dingchuan cough " (" book on Chinese herbal medicine covers bamboo fish trap ") " disappear phlegm in the heart " (" haigoushen "), is tonifying lung key medicine；The lung being damaged by lasted cough, scorching impairment of yin,
The caused deficiency syndrome of the lung or deficiency of both the lung and kidney person, available this product compatibility application.Ginseng reinforces vital energy, and then body fluid is full and not thirsty for gas foot,
Old friend's ginseng can promote the production of body fluid to quench thirst, and be used for body fluid deficiency syndrome, diabete.Ginseng reinforces vital energy, and vigour is filled, and the motive must support, and the mind obtains rather, the heart
Intelligence obtains clever, and has the effect of tranquilize the mind and promote the intelligence, for treating deficiency of heart-QI or heart kidney qi deficiency, the insomnia of heart spleen deficiency, amnesia etc..Ginseng
Gan Wen reinforces vital energy, and QI invigorating has the benefits of qi-blood tonifying with green blood, thus it is available control deficiency of spleen-QI and stomach-QI, it is insufficient to change source, blood deficiency chlorosis it
Card；Energy QI invigorating with supporing yang, therefore again with insufficiency of primordial QI, the Yang-function insufficiency of kidneyzang is controlled, demonstrate,prove by impotence palace cold etc. again.
In short, the function of ginseng is focused on and is reinforced vital energy, can also tonifying lung gas, enriching spleen-QI, bushing gas, kidney tonifying gas and promote the production of body fluid, calm the nerves
Intelligence development, therefore (Pharmacopoeia of the People's Republic of China clinical application palpus is compiled by Chinese Pharmacopoeia Commission to control the first key medicine of consumptive disease internal injury
Know that the prepared slices of Chinese crude drugs are rolled up, version in 2015, page 1227).
Shennong's Herbal " main tonifying five zang organs, soothe the nerves determine soul, and stop palpitate with fear removes pathogenic factor, improving eyesight, happily, intelligence development." " medicine
Property opinion) " main five hiding unsaturated vapor, the deficient impotence of general debility is weak, spit it is inverse do not eat, only cholera unhappiness vomiting, tonifying five zang organs six internal organs, Bao Zhongshou
Mind." Compendium of Material Medica " all asthenic symptoms of male woman are controlled, generate heat spontaneous perspiration, dizziness and headache, and regurgitation and emesis cuts off from malaria, and it slides and rushes down protracted dysentery, urine frequency
Number leaching drip, overstrain internal injury, apoplexy heatstroke, flaccidity syndrome and arthralgia syndrome are spitted blood, blood of coughing, lower blood, blood strangury, metrorrhagia, postpartum all diseases before tire."
Fructus lycii is the dry mature fruit of Lycium barbarum L. of solanaceae Lycium barbarum L..
Fructus lycii nature and flavor sweet and neutral.Return liver and kidney channel.Has nourishing liver and kidney, benefiting shrewd head function.For consumption consumptive loss, waist and knee acid
Bitterly, dizziness and tinnitus, impotence and seminal emission, Heat Diabetes, blood deficiency chlorosis, blurred vision.
Utility analysis: fructus lycii is sweet in flavor mild-natured, enters liver kidney channel, is longer than nourshing kidney essence, tonifying liver blood, " Bencao Jingshu " says it: " for
Liver kidney kidney-KIN being deficient, the tired interior key medicine for vulcanizing benefit ", slides soreness and weakness of waist and knees caused by liver kidney blood and essence asthenia, dizziness and tinnitus, spermatorrhea
Smart, infertile, blurred vision etc. can apply.Fructus lycii energy benefiting essence-blood, " tranquilizing the mind " (" haigoushen "), can be used for deficiency of blood complexion
Sallow, palpitaition is out of strength；Puerperal exposure to wind consumptive disease damage, limbs pain, mind dysphoria, loss of appetite；Hematasthenic cough, night sweat spontaneous perspiration, hectic fever due to yin
Hectic fever, it is dysphoria in chestpalms-soles；Internal lesion caused by overexertion is deficient, and four limbs are thin thin out of strength；Married woman's postpartum deficient qi and blood, (the National Pharmacopeia committee member such as oligogalactia
Pharmacopoeia of the People's Republic of China clinical application notice prepared slices of Chinese crude drugs volume, version in 2015, page 1230 can be compiled).
Collective Notes to the Canon of Materia medica " nourishing the essence and strengthening QI, prosperous and powerful vagina." " haigoushen " " energy help essence various symptims and signs of deficiency, Yi Yanse bleach,
Improving eyesight calms the nerves, makes us long-lived."
Mulberry fruit is the drying fruit ear of moraceae plants mulberry Morus alba L..
Mulberry fruit nature and flavor are sweet, sour, tremble with fear.Return heart, liver and kidney channel.Have nourishing yin and supplementing blood, fluid dryness function.It is dizzy for the deficiency of liver-yin and kidney-yin
Dizzy tinnitus, palpitation and insomnia, poliosis, injury thirst, Heat Diabetes, dry constipation of intestines.
Utility analysis: mulberry fruit acid sweet in flavor, the special nourishing yin and supplementing blood of function, " the southern regions of the Yunnan Province book on Chinese herbal medicine " cloud: " kidney-nourishing is dirty and controlling nocturnal emission with astringent drugs, long term usage dark hair
Improving eyesight ".Therefore it is usually used in kidney deficiency and liver, the dizziness and tinnitus of deficiency of YIN-blood, mesh is secretly dim-sighted, soreness and weakness of waist and knees, poliosis etc..
Mulberry fruit is sweet cold, is longer than nourishing yin and removing heat, promotes the production of body fluid to quench thirst, " Tang materia medica " says it: " single food, master quench one's thirst ".Both it can be used and control
Excessive heat damaging fluid is thirsty, and available control yin asthenia generating intrinsic heat and quench one's thirst.
Mulberry fruit nourishing yin and supplementing blood, ease constipation of promoting the production of body fluid, therefore can be used again and control the withered dry constipation of intestines card of yin deficiency saliva.(Chinese Pharmacopoeia Commission
Compile Pharmacopoeia of the People's Republic of China clinical application notice prepared slices of Chinese crude drugs volume, version in 2015, page 1238).
" Bencao Jingshu " " essence of mulberry fruit person, mulberry are tied.Its is sweet in flavor, and gas is cold, purple after color is just red, rich in gas.
In conjunction it, Gan Hanyi blood and except heat, for cool blood enrich blood benefiting yin medicine undoubtedly.It quenches one's thirst since body fluid deficiency for interior heat, promotes the production of body fluid
Therefore quench the thirst.The five internal organs all belong to yin, benefiting yin event relieving the five internal organs.The vim and vigour in asthenic yin then joint are obstructed, and blood promotes the production of body fluid full, and negative gas is long to be contained, then not
Hungry and vim and vigour are from logical.Heat moves back yin and make then that the liver heart is without fire, therefore soul peace and mind, from clear peaceful, the clear then clever interior hair of mind, yin then bleaches again
It is not old.It is sweet to tremble with fear except heat, therefore wine poison in solution.Cold in nature and downlink Li Shui, thus sharp aqueous vapor and reduce swelling."
Essentials of Matea Medica " mulberry fruit, sweet and cool-natured.Color it is black enter kidney and moisturizing, relieving the five internal organs joint, spirit sedation, hearing-improing and eyesight improving promote the production of body fluid only
Yearningly, it is thirsty to subdue metal and stone medicine heat for cream refining."
Jujube is the dry mature fruit of Rhamnaceae plant jujube Ziziphus jujuba Mill..Its medicinal material processing is except impurity elimination
Matter is cleaned, is dried.Used time stoning.
Jujube nature and flavor sweet, warm.Returns spleen, stomach, the heart channel of Hang-Shaoyin.Have tonifying middle-Jiao and Qi, nourishing blood and tranquilization function.It is out of strength for spleen eating less
Loose stool, hysteria of womam.
Utility analysis: the sweet temperature of jujube enters taste warp, has the function of tonifying middle-Jiao and Qi, but the efficacy of a drug is gentle, mostly harmonizing the spleen and stomach is normal
With adjuvant, therefore it is usually used in treating weakness of the spleen and the stomach, the deficiency of vital energy is insufficient, fatigue and weakness, anorexia and loose stool etc..
The sweet temperature of jujube, can by tonifying Qi with green blood and nourishing blood and tranquilization the benefits of, can both control spleen deficiency and be unable to green blood, the deficiency of vital energy
Blood is few, sallow complexion, palpitation and insomnia, and can control women's deficiency of YIN-blood, depressed emotion, confused and worried hysteria syndrome.In addition, jujube
Gan Huan has mitigation pharmacological property effect (Chinese Pharmacopoeia Commission's volume Pharmacopoeia of the People's Republic of China clinical application of similar Radix Glycyrrhizae
Notice prepared slices of Chinese crude drugs volume, version in 2015, page 1110).
" Wu Pu Bencao " " beneficial temper, has made us color, U.S. ambition in homophony." " Mingyi Bielu " " tonifying middle-Jiao and Qi, strength,
Except unhappiness, treats and hanged under the heart." " Changsha medicine solution " " its taste is dense and matter is thick, then is longer than and enriches blood."
The preparation of the above-mentioned compound Polygonatum combined extracts of the present invention, plays coordination and reconciliation between so that medicinal material is combined
Effective application, to be taken off to physically weak, spleen eating less, deficiency of spleen-QI and stomach-QI, fatigue and asthenia, consumption consumptive loss, the syndromes such as deficiency of liver-yin and kidney-yin have
Good reconciliation effect.The modern crafts that are prepared by of compound Polygonatum combined extracts extract its medicinal material essence, can be conducive to medicine
Material dosage is reduced, and convenient to take, can also facilitating can on compound Polygonatum combined extracts and pharmacy or food from application
Granule, tablet, capsule, pill, oral solution or wine product etc. are hybridly prepared into the auxiliary material of receiving；Wherein tablet can be with excellent
Effervescent tablet, chewable tablets, buccal tablet are selected, because effervescent tablet, chewable tablets, buccal tablet have the following obviously excellent compared with conventional tablet
Gesture: (1) a certain amount of sugar will be added as tax due to preparing these tablets in convenient to take, chewable clothes, buccal, Ke Huashui
Shape agent, thus in good taste, people gladly take, and effervescent tablet adds after water self-dissolving like one glass of beverage, and people is made to be happy to drink；(2)
Absorb fast, bioavilability height；(3) easy to carry, convenient transportation；(4) it is easy to quantify, dosage is accordingly accurate；Wherein capsule
It can be prepared into soft capsule and hard capsule, wherein pill can be prepared into water pill, dripping pill, pellet and honeyed bolus；Described in wherein
Wine product are absorbed since wine can promote contained Chinese medicinal ingredients, have with tincture pharmaceutically, utilized in order to facilitate the people that happiness is drunk
It drinks and reaches health-care effect, while also to there is the hobby to different demands of drinking, can be selected has white wine, grape wine, yellow rice wine and beer
Wine, is blent, the known method that is aged is prepared into white wine, grape wine, yellow rice wine and beer product, so that the people of different demands select
With.
Specific embodiment
It is that the present invention is further illustrated, but does not constitute any limit to the scope of the present invention by following embodiment
System.
Embodiment 1
The preparation of compound Polygonatum combined extracts:
(1) pharmaceutical composition: rhizoma polygonati 1.5kg, ginseng 0.9kg, fructus lycii 1.2kg, mulberry fruit 1.2kg, jujube 1.1kg's and 5.9kg
Beta-cyclodextrin,
(2) preparation method: (1) first respectively drying Chinese medicine rhizoma polygonati, ginseng, fructus lycii, mulberry fruit, jujube, then weighs baking
Rhizoma polygonati, ginseng, fructus lycii, mulberry fruit after dry, that jujube pulverizes into 10 mesh powder respectively is spare；(2) 2.7kg concentration is added in ginseng pulverate
It for the edible alcohol of 99%v/v, impregnates 12 days, is sufficiently stirred daily during immersion 1 time, after immersion under normal temperature state, filter
Alcohol soak is taken to save backup, filter residue is spare；(3) rhizoma polygonati, fructus lycii, mulberry fruit, all medicinal powder of jujube are mixed and is added 50kg's
After impregnating 4 hours, the filter residue in step (2) is added for pure water, and heating is boiled 2 hours, and the another device of leaching decoction liquor saves, filter
The pure water of 40kg is added in slag, and boiling is added to boil 1 hour, and the another device of leaching decoction liquor saves, and filter residue adds the pure water of 25kg, adds
Boiling is boiled 0.5 hour, and leaching decoction liquor discards filter residue；(4) by decoction liquor merging three times in step (3), 150 meshes are crossed, through dense
Be reduced to specific gravity be 5.0 concentrate it is spare；(5) alcohol soak obtained by step (2) is merged with concentrate obtained by step (4),
The beta-cyclodextrin of 5.9kg is added, is placed in ball mill and be fully ground 3 hours, after grinding, material is taken out, through drying
It is 5.8%w/w to water content, is pulverized, crosses 80 meshes to get compound Polygonatum combined extracts.
Routinely granule, tablet, capsule, pill or oral solution is made in technique to the compound Polygonatum combined extracts
As the purposes for being prepared into functional food.
The compound Polygonatum combined extracts and existing white wine, grape wine, yellow rice wine or beer are blent, are aged conduct
It is prepared into the purposes of wine product.
Embodiment 2
The preparation of compound Polygonatum combined extracts:
(1) pharmaceutical composition: rhizoma polygonati 1.1kg, ginseng 0.6kg, fructus lycii 0.9kg, mulberry fruit 1.1kg, jujube 1.0kg's and 4.7kg
Hydroxyethyl-β-cyclodextrin,
(2) preparation method: (1) first respectively drying Chinese medicine rhizoma polygonati, ginseng, fructus lycii, mulberry fruit, jujube, then weighs baking
Rhizoma polygonati, ginseng, fructus lycii, mulberry fruit after dry, that jujube pulverizes into 10 mesh powder respectively is spare；(2) 1.8kg concentration is added in ginseng pulverate
It for the edible alcohol of 99%v/v, impregnates 12 days, is sufficiently stirred daily during immersion 1 time, after immersion under normal temperature state, filter
Alcohol soak is taken to save backup, filter residue is spare；(3) rhizoma polygonati, fructus lycii, mulberry fruit, all medicinal powder of jujube are mixed and is added 41kg's
After impregnating 4 hours, the filter residue in step (2) is added for pure water, and heating is boiled 2 hours, and the another device of leaching decoction liquor saves, filter
The pure water of 32.8kg is added in slag, and boiling is added to boil 1 hour, and the another device of leaching decoction liquor saves, and filter residue adds the pure of 20.5kg
Water adds boiling to boil 0.5 hour, and leaching decoction liquor discards filter residue；(4) by decoction liquor merging three times in step (3), 150 mesh are crossed
Sieve, it is concentrated to specific gravity be 5.0 concentrate it is spare；(5) it will be concentrated obtained by alcohol soak obtained by step (2) and step (4)
Liquid merges, and the hydroxyethyl-β-cyclodextrin of 4.7kg is added, is placed in ball mill and be fully ground 3 hours, after grinding, take
Material out is 5.2%w/w through drying to water content, is pulverized, and crosses 80 meshes to get compound Polygonatum combined extracts.
Routinely granule, tablet, capsule, pill or oral solution is made in technique to the compound Polygonatum combined extracts
As the purposes for being prepared into functional food.
The compound Polygonatum combined extracts and existing white wine, grape wine, yellow rice wine or beer are blent, are aged conduct
It is prepared into the purposes of wine product.
Embodiment 3
The preparation of compound Polygonatum combined extracts:
(1) pharmaceutical composition: rhizoma polygonati 1.2kg, ginseng 0.5kg, fructus lycii 1.0kg, mulberry fruit 1.0kg, jujube 0.8kg's and 4.5kg
Hydroxypropyl-β-cyclodextrin,
(2) preparation method: (1) first respectively drying Chinese medicine rhizoma polygonati, ginseng, fructus lycii, mulberry fruit, jujube, then weighs baking
Rhizoma polygonati, ginseng, fructus lycii, mulberry fruit after dry, that jujube pulverizes into 10 mesh powder respectively is spare；(2) 1.5kg concentration is added in ginseng pulverate
It for the edible alcohol of 99%v/v, impregnates 12 days, is sufficiently stirred daily during immersion 1 time, after immersion under normal temperature state, filter
Alcohol soak is taken to save backup, filter residue is spare；(3) rhizoma polygonati, fructus lycii, mulberry fruit, all medicinal powder of jujube are mixed and is added 40kg's
After impregnating 4 hours, the filter residue in step (2) is added for pure water, and heating is boiled 2 hours, and the another device of leaching decoction liquor saves, filter
The pure water of 32kg is added in slag, and boiling is added to boil 1 hour, and the another device of leaching decoction liquor saves, and filter residue adds the pure water of 20kg, adds
Boiling is boiled 0.5 hour, and leaching decoction liquor discards filter residue；(4) by decoction liquor merging three times in step (3), 150 meshes are crossed, through dense
Be reduced to specific gravity be 5.0 concentrate it is spare；(5) alcohol soak obtained by step (2) is merged with concentrate obtained by step (4),
The hydroxypropyl-β-cyclodextrin of 4.5kg is added, is placed in ball mill and be fully ground 3 hours, after grinding, takes out material,
It is 5.5%w/w through drying to water content, is pulverized, crosses 80 meshes to get compound Polygonatum combined extracts.
Routinely granule, tablet, capsule, pill or oral solution is made in technique to the compound Polygonatum combined extracts
As the purposes for being prepared into functional food.
The compound Polygonatum combined extracts and existing white wine, grape wine, yellow rice wine or beer are blent, are aged conduct
It is prepared into the purposes of wine product.
Embodiment 4
The preparation of compound Polygonatum combined extracts:
(1) pharmaceutical composition: rhizoma polygonati 1.0kg, ginseng 0.7kg, fructus lycii 0.8kg, mulberry fruit 1.1kg, jujube 1.2kg's and 4.8kg
2,6- dimethyl-β-cyclodextrins,
(2) preparation method: (1) first respectively drying Chinese medicine rhizoma polygonati, ginseng, fructus lycii, mulberry fruit, jujube, then weighs baking
Rhizoma polygonati, ginseng, fructus lycii, mulberry fruit after dry, that jujube pulverizes into 10 mesh powder respectively is spare；(2) 2.1kg concentration is added in ginseng pulverate
It for the edible alcohol of 99%v/v, impregnates 12 days, is sufficiently stirred daily during immersion 1 time, after immersion under normal temperature state, filter
Alcohol soak is taken to save backup, filter residue is spare；(3) rhizoma polygonati, fructus lycii, mulberry fruit, all medicinal powder of jujube are mixed and is added 41kg's
After impregnating 4 hours, the filter residue in step (2) is added for pure water, and heating is boiled 2 hours, and the another device of leaching decoction liquor saves, filter
The pure water of 32.8kg is added in slag, and boiling is added to boil 1 hour, and the another device of leaching decoction liquor saves, and filter residue adds the pure of 20.5kg
Water adds boiling to boil 0.5 hour, and leaching decoction liquor discards filter residue；(4) by decoction liquor merging three times in step (3), 150 mesh are crossed
Sieve, it is concentrated to specific gravity be 5.0 concentrate it is spare；(5) it will be concentrated obtained by alcohol soak obtained by step (2) and step (4)
Liquid merges, and 2, the 6- dimethyl-β-cyclodextrin of 4.8kg is added, is placed in ball mill and be fully ground 3 hours, grinding terminates
Afterwards, material is taken out, is 5.3%w/w through drying to water content, is pulverized, crosses 80 meshes to get compound Polygonatum combined extracts.
Routinely granule, tablet, capsule, pill or oral solution is made in technique to the compound Polygonatum combined extracts
As the purposes for being prepared into functional food.
The compound Polygonatum combined extracts and existing white wine, grape wine, yellow rice wine or beer are blent, are aged conduct
It is prepared into the purposes of wine product.
Embodiment 5
The preparation of compound Polygonatum combined extracts:
(1) pharmaceutical composition: rhizoma polygonati 1.3kg, ginseng 0.8kg, fructus lycii 1.1kg, mulberry fruit 0.9kg, jujube 1.0kg's and 5.1kg
Sulfobutyl ether-beta-cyclodextrin,
(2) preparation method: (1) first respectively drying Chinese medicine rhizoma polygonati, ginseng, fructus lycii, mulberry fruit, jujube, then weighs baking
Rhizoma polygonati, ginseng, fructus lycii, mulberry fruit after dry, that jujube pulverizes into 10 mesh powder respectively is spare；(2) 2.4kg concentration is added in ginseng pulverate
It for the edible alcohol of 99%v/v, impregnates 12 days, is sufficiently stirred daily during immersion 1 time, after immersion under normal temperature state, filter
Alcohol soak is taken to save backup, filter residue is spare；(3) rhizoma polygonati, fructus lycii, mulberry fruit, all medicinal powder of jujube are mixed and is added 43kg's
After impregnating 4 hours, the filter residue in step (2) is added for pure water, and heating is boiled 2 hours, and the another device of leaching decoction liquor saves, filter
The pure water of 34.4kg is added in slag, and boiling is added to boil 1 hour, and the another device of leaching decoction liquor saves, and filter residue adds the pure of 21.5kg
Water adds boiling to boil 0.5 hour, and leaching decoction liquor discards filter residue；(4) by decoction liquor merging three times in step (3), 150 mesh are crossed
Sieve, it is concentrated to specific gravity be 5.0 concentrate it is spare；(5) it will be concentrated obtained by alcohol soak obtained by step (2) and step (4)
Liquid merges, and the sulfobutyl ether-beta-cyclodextrin of 5.1kg is added, is placed in ball mill and be fully ground 3 hours, after grinding,
Material is taken out, is 5.6%w/w through drying to water content, is pulverized, crosses 80 meshes to get compound Polygonatum combined extracts.
Routinely granule, tablet, capsule, pill or oral solution is made in technique to the compound Polygonatum combined extracts
As the purposes for being prepared into functional food.
The compound Polygonatum combined extracts and existing white wine, grape wine, yellow rice wine or beer are blent, are aged conduct
It is prepared into the purposes of wine product.
Embodiment 6
The preparation of compound Polygonatum combined extracts:
(1) pharmaceutical composition: rhizoma polygonati 0.9kg, ginseng 0.3kg, fructus lycii 0.7kg, mulberry fruit 1.5kg, jujube 1.5kg's and 4.9kg
Hydroxypropyl-β-cyclodextrin,
(2) preparation method: (1) first respectively drying Chinese medicine rhizoma polygonati, ginseng, fructus lycii, mulberry fruit, jujube, then weighs baking
Rhizoma polygonati, ginseng, fructus lycii, mulberry fruit after dry, that jujube pulverizes into 10 mesh powder respectively is spare；(2) 0.9kg concentration is added in ginseng pulverate
It for the edible alcohol of 99%v/v, impregnates 12 days, is sufficiently stirred daily during immersion 1 time, after immersion under normal temperature state, filter
Alcohol soak is taken to save backup, filter residue is spare；(3) rhizoma polygonati, fructus lycii, mulberry fruit, all medicinal powder of jujube are mixed and is added 46kg's
After impregnating 4 hours, the filter residue in step (2) is added for pure water, and heating is boiled 2 hours, and the another device of leaching decoction liquor saves, filter
The pure water of 36.8kg is added in slag, and boiling is added to boil 1 hour, and the another device of leaching decoction liquor saves, and filter residue adds the pure water of 23kg,
Boiling is added to boil 0.5 hour, leaching decoction liquor discards filter residue；(4) by decoction liquor merging three times in step (3), 150 meshes, warp are crossed
Be concentrated into specific gravity be 5.0 concentrate it is spare；(5) concentrate obtained by alcohol soak obtained by step (2) and step (4) is closed
And the hydroxypropyl-β-cyclodextrin of 4.9kg is added, and it is placed in and carries out being fully ground 3 hours, after grinding in ball mill, extract
Material is 5.0%w/w through drying to water content, is pulverized, and crosses 80 meshes to get compound Polygonatum combined extracts.
Routinely granule, tablet, capsule, pill or oral solution is made in technique to the compound Polygonatum combined extracts
As the purposes for being prepared into functional food.
The compound Polygonatum combined extracts and existing white wine, grape wine, yellow rice wine or beer are blent, are aged conduct
It is prepared into the purposes of wine product.
Claims (9)
1. a kind of preparation method of compound Polygonatum combined extracts, which is characterized in that it is by the Chinese medicine material of following parts by weight
Rhizoma polygonati 9-15, ginseng 3-9, fructus lycii 6-12, mulberry fruit 9-15, jujube 6-15 and cyclodextrin system with the parts by weight such as Chinese medicine material
At,
Specifically the preparation method is as follows: (1) first respectively dries Chinese medicine rhizoma polygonati, ginseng, fructus lycii, mulberry fruit, jujube, so
Rhizoma polygonati, ginseng, fructus lycii after weighing drying afterwards, mulberry fruit, that jujube pulverizes into 10 mesh powder respectively is spare；(2) ginseng pulverate is pressed into medicine
Material total weight ratio is the alcohol that 1:3 is added that concentration is 99%v/v, is impregnated 12 days under normal temperature state, during immersion daily sufficiently
Stirring 1 time, after immersion, leaching alcohol soak is saved backup, and filter residue is spare；(3) by rhizoma polygonati, fructus lycii, mulberry fruit, jujube
After all medicinal powder mixing are added water immersion 4 hours that medicinal material total weight ratio is 1:10, the filter residue in step (2) is added, heating
It boils 2 hours, the another device of leaching decoction liquor saves, and the water that medicinal material total weight ratio is 1:8 is added in filter residue, adds boiling to boil 1 hour, filter
The another device of decoction liquor is taken to save, filter residue adds the water that medicinal material total weight ratio is 1:5, and boiling is added to boil 0.5 hour, and leaching decocts
Liquid discards filter residue；(4) by decoction liquor merging three times in step (3), 150 meshes are crossed, it is concentrated to obtain concentrate to specific gravity for 5.0
It is spare；(5) alcohol soak obtained by step (2) is merged with concentrate obtained by step (4), ring paste is added by medicinal material total weight parts
Essence is placed in ball mill and be fully ground 3 hours, after grinding, takes out material, is dried to water content < 6%w/w,
It pulverizes, crosses 80 meshes to get compound Polygonatum combined extracts.
2. a kind of preparation method of compound Polygonatum combined extracts, which is characterized in that it is by the Chinese medicine material of following parts by weight
Rhizoma polygonati 10-12, ginseng 5-7, fructus lycii 8-10, mulberry fruit 10-12, jujube 8-12 and cyclodextrin system with the parts by weight such as Chinese medicine material
At,
Specifically the preparation method is as follows: (1) first respectively dries Chinese medicine rhizoma polygonati, ginseng, fructus lycii, mulberry fruit, jujube, so
Rhizoma polygonati, ginseng, fructus lycii after weighing drying afterwards, mulberry fruit, that jujube pulverizes into 10 mesh powder respectively is spare；(2) ginseng pulverate is pressed into medicine
Material total weight ratio is the alcohol that 1:3 is added that concentration is 99%v/v, is impregnated 12 days under normal temperature state, during immersion daily sufficiently
Stirring 1 time, after immersion, leaching alcohol soak is saved backup, and filter residue is spare；(3) by rhizoma polygonati, fructus lycii, mulberry fruit, jujube
After all medicinal powder mixing are added water immersion 4 hours that medicinal material total weight ratio is 1:10, the filter residue in step (2) is added, heating
It boils 2 hours, the another device of leaching decoction liquor saves, and the water that medicinal material total weight ratio is 1:8 is added in filter residue, adds boiling to boil 1 hour, filter
The another device of decoction liquor is taken to save, filter residue adds the water that medicinal material total weight ratio is 1:5, and boiling is added to boil 0.5 hour, and leaching decocts
Liquid discards filter residue；(4) by decoction liquor merging three times in step (3), 150 meshes are crossed, it is concentrated to obtain concentrate to specific gravity for 5.0
It is spare；(5) alcohol soak obtained by step (2) is merged with concentrate obtained by step (4), ring paste is added by medicinal material total weight parts
Essence is placed in ball mill and be fully ground 3 hours, after grinding, takes out material, is dried to water content < 6%w/w,
It pulverizes, crosses 80 meshes to get compound Polygonatum combined extracts.
3. a kind of preparation method of compound Polygonatum combined extracts, which is characterized in that it is by the Chinese medicine material of following parts by weight
Rhizoma polygonati 11, ginseng 6, fructus lycii 9, mulberry fruit 11 and are made jujube 10 with the cyclodextrin of the parts by weight such as Chinese medicine material,
Preparation method is as follows: (1) first respectively drying Chinese medicine rhizoma polygonati, ginseng, fructus lycii, mulberry fruit, jujube, then
Rhizoma polygonati, ginseng, fructus lycii after weighing drying, mulberry fruit, that jujube pulverizes into 10 mesh powder respectively is spare；(2) ginseng pulverate is pressed into medicinal material
Total weight ratio is the alcohol that 1:3 is added that concentration is 99%v/v, impregnates 12 days under normal temperature state, sufficiently stirs daily during immersion
It mixes 1 time, after immersion, leaching alcohol soak saves backup, and filter residue is spare；(3) rhizoma polygonati, fructus lycii, mulberry fruit, jujube is all
After medicinal powder mixing is added water immersion 4 hours that medicinal material total weight ratio is 1:10, the filter residue in step (2) is added, heating is boiled
Boiling 2 hours, the another device of leaching decoction liquor save, and the water that medicinal material total weight ratio is 1:8 is added in filter residue, add boiling to boil 1 hour, leaching
The another device of decoction liquor saves, and filter residue adds the water that medicinal material total weight ratio is 1:5, and boiling is added to boil 0.5 hour, leaching decoction liquor,
Discard filter residue；(4) by step (3) three times decoction liquor merge, cross 150 meshes, it is concentrated to specific gravity be 5.0 concentrate it is standby
With；(5) alcohol soak obtained by step (2) is merged with concentrate obtained by step (4), ring paste is added by medicinal material total weight parts
Essence is placed in ball mill and be fully ground 3 hours, after grinding, takes out material, is dried to water content < 6%w/w,
It pulverizes, crosses 80 meshes to get compound Polygonatum combined extracts.
4. method according to claim 1 to 3, which is characterized in that the cyclodextrin (CYD) is beta-cyclodextrin (β-
CYD), 2,6- dimethyl-β-cyclodextrin (DM- β -- CYD), hydroxyethyl-β-cyclodextrin (HE- β-CYD), hydroxypropyl-β-cyclodextrin
Any one in (HP- β-CYD) and sulfobutyl ether-beta-cyclodextrin (SBE- β-CYD).
5. method according to claim 1 to 3, which is characterized in that the alcohol is food grade alcohol；The water is
Pure water.
6. method according to claim 1 to 3, which is characterized in that the drying is vacuum drying；The vacuum drying
Condition be temperature 50 C, vacuum degree 0.2kPa.
7. the purposes of -3 compound Polygonatum combined extracts according to claim 1, which is characterized in that routinely technique is made
Granula, tablet, capsule, pill, oral solution are as the purposes for preparing functional food or wine product.
8. purposes according to claim 7, which is characterized in that the tablet is effervescent tablet, chewable tablets and buccal tablet；Institute
The capsule stated is soft capsule and hard capsule；The pill is water pill, dripping pill, pellet and honeyed bolus.
9. purposes according to claim 7, which is characterized in that the wine is white wine, grape wine, yellow rice wine and beer.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110559389A (en) * | 2019-09-23 | 2019-12-13 | 阳元贵 | traditional Chinese medicine wine for treating hyperuricemia, gout and rheumatism and preparation method thereof |
| CN110742274A (en) * | 2019-11-18 | 2020-02-04 | 河南敬一医药科技有限公司 | Prescription and process for improving healthy energy of human body and resisting aging |
| CN111358922A (en) * | 2020-02-27 | 2020-07-03 | 广西玉林制药集团有限责任公司 | Traditional Chinese medicine composition for warming and invigorating kidney yang and improving cold constitution and preparation method and application thereof |
| CN114982887A (en) * | 2022-05-25 | 2022-09-02 | 四川兰冰生物药业有限公司 | Ginseng and rhizoma polygonati plant beverage and preparation method thereof |
-
2019
- 2019-05-16 CN CN201910407842.1A patent/CN110075215A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110559389A (en) * | 2019-09-23 | 2019-12-13 | 阳元贵 | traditional Chinese medicine wine for treating hyperuricemia, gout and rheumatism and preparation method thereof |
| CN110742274A (en) * | 2019-11-18 | 2020-02-04 | 河南敬一医药科技有限公司 | Prescription and process for improving healthy energy of human body and resisting aging |
| CN111358922A (en) * | 2020-02-27 | 2020-07-03 | 广西玉林制药集团有限责任公司 | Traditional Chinese medicine composition for warming and invigorating kidney yang and improving cold constitution and preparation method and application thereof |
| CN114982887A (en) * | 2022-05-25 | 2022-09-02 | 四川兰冰生物药业有限公司 | Ginseng and rhizoma polygonati plant beverage and preparation method thereof |
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Application publication date: 20190802 |