CN110075035A - A kind of hair restorer of the part containing hair stroma cell activator - Google Patents
A kind of hair restorer of the part containing hair stroma cell activator Download PDFInfo
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- CN110075035A CN110075035A CN201910496926.7A CN201910496926A CN110075035A CN 110075035 A CN110075035 A CN 110075035A CN 201910496926 A CN201910496926 A CN 201910496926A CN 110075035 A CN110075035 A CN 110075035A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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Abstract
The present invention relates to cosmetic technical fields, and in particular to a kind of hair restorer and preparation method thereof of part containing hair stroma cell activator.A kind of hair restorer of the part containing hair stroma cell activator, by weight, including 0.1-5 parts of cholesteric -3,5- diene, 0.5-6 parts of hair restorer, 0.2-1 parts of antiandrogen be used as effective component.Part is with the hair restorer containing hair stroma cell activator by using cholesteric -3 prepared by the present invention, 5- diene, hair restorer, antiandrogen are as effective component, it is cooperateed with together with biologically active polypeptide, white birch extract, when being acted on scalp, not only there is the growth of hair papilla cell, and it is proved by clinical trial results, it can significantly improve scalp environment, promote natural on-off cycles of hair growth, therefore, product of the present invention can be used in preventing hair loss, improve alopecia, hair growth or the cosmetics or skin preparations for extenal use that promote hair tonic.
Description
Technical field
The invention belongs to cosmetic technical fields, more particularly it relates to which a kind of part is thin with hair matrix is contained
The hair restorer of born of the same parents' activator.
Background technique
Excessive male hormones effect, poor circulation, the scalp function as caused by peroxide and bacterium etc.
The reason of decline, inherent cause, aging, pressure etc. are considered as depilation, but the reason of do not know depilation so far.In recent years
Come, due to unbalanced nutrition caused by changing because of dietetic life, because of degree of pressure caused by environmental pollution and social environment
The reasons such as increase, worry that the ratio of the population of depilation is increasing, the age is continuing to reduce, and worries the female population of depilation
Ratio also increase step by step.
In order to treat and prevent such depilation, having developed has the function of for stimulating blood circulation, strengthening hair follicle, head
Skin moisturizing and inhibit male hormones make formula as main component with estrogen, or have that minoxidil, non-that is male
The formula of amine, mucopolysaccharide auxin (Trichosaccharide) etc..Minoxidil is also unknown to the mechanism of action of hair growth
Really, but it is believed that by blood vessel dilatation have additional nutrients object supply and open potassium channel effect come induced hair growth.It is non-that
Male amine is 5- alpha reductase inhibitor, the drug as treatment prostate and the drug by different dosage prevention depilations.It is viscous more
Sugared auxin is excellent drug in terms of convenience and efficiency.However, since the reagent for being used to prepare Finasteride is expensive
Or it is highly toxic, so there are problems that manufacturing cost is high and pollute environment.In particular, having the following problems: due to being difficult to
By-product is removed, so the purity of target product reduces；And the reagent inhibited by water and work are easy due to using its activity
Property derivative, so being difficult to mass production.
Summary of the invention
To solve the above-mentioned problems, first aspect of the present invention provides a kind of local with containing the activation of hair stroma cell
The hair restorer of agent, by weight, including 0.1-5 parts of cholesterine, 0.5-6 parts of potassium channel openers be used as effective component.
As a kind of perferred technical scheme, the cholesteric general structure are as follows:
Wherein, R indicates the isomery alkyl of C3-C9.
As a kind of perferred technical scheme, the potassium channel openers are selected from minoxidil, diazoxiide, carnitine, ox sulphur
One of acid etc. are a variety of.
It as a kind of perferred technical scheme, by weight, further include 0.1-3 parts of biologically active polypeptide, white birch extraction
1-3 parts of object.
As a kind of perferred technical scheme, the biologically active polypeptide is acetyl group tetrapeptide.
As a kind of perferred technical scheme, the acetyl group tetrapeptide is selected from acetyl group tetrapeptide -2, acetyl group tetrapeptide -3, second
Acyl group tetrapeptide -5, acetyl group tetrapeptide -9, acetyl group tetrapeptide -11, acetyl group tetrapeptide -12, acetyl group tetrapeptide -15, acetyl group tetrapeptide -
One of 17 or a variety of.
It as a kind of perferred technical scheme, by weight, further include 1-20 parts of glucan, 10-30 parts of butanediol, water
50-100 parts.
As a kind of perferred technical scheme, the biologically active polypeptide, white birch extract, cholesteric weight ratio are 1:
(1-2):(1-2)。
As a kind of perferred technical scheme, the glucan, potassium channel openers weight ratio be (3-10): 1.
The second aspect of the present invention provides a kind of hair restorer of the above-mentioned part containing hair stroma cell activator
Using, the composition be applied to hair oil, embellish hair essence, brighten the hair element, hair-cream liquid, trichotrophy lotion, shampoo, hair conditioner,
Treatment wax, hair-cream, trichotrophy frost, hair moisturiser, hair massage cream, pomade, hair aerosol, hair film, trichotrophy film,
Hair soap, shining shampoo milk, trichoxerosis agent, hair save inorganic agent, hair dye, hair wavy hair agent, drift hair cream, hair jelly, hair
Glaze, hair cosmetic agent, hair lacquer, hair moisturizer, hair mousse, hair spray.
The utility model has the advantages that part is with the hair restorer containing hair stroma cell activator by using gallbladder prepared by the present invention
Sterol, potassium channel openers cooperate with together as effective component and biologically active polypeptide, white birch extract, are acted on head
When on skin, not only there is the growth of hair papilla cell, but also prove by clinical trial results, can significantly improve scalp
Environment promotes natural on-off cycles of hair growth, and therefore, product of the present invention can be used in preventing hair loss, improve alopecia, hair growth or promote hair tonic
Cosmetics or skin preparations for extenal use.
Detailed description of the invention
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art
Embodiment or attached drawing needed to be used in the description of the prior art be briefly described, it should be apparent that, it is described below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, is also possible to obtain other drawings based on these drawings.
Fig. 1: case.
Specific embodiment
It is further clear, complete that the technical characteristic work in technical solution is provided to the present invention With reference to embodiment
Description, not to the limitation of its protection scope.
Word " preferred ", " preferred " in the present invention etc. refer to, can provide in some cases certain beneficial to effect
The embodiment of the present invention of fruit.However, other embodiments are also likely to be preferred under identical circumstances or in the case of other
's.In addition, do not imply that other embodiments are unavailable to the statement of one or more preferred embodiments, be also not intended to by
Other embodiments exclude except the scope of the present invention.
When a numberical range disclosed herein, above range is considered as continuously, and the minimum value including the range and most
Big value and each value between this minimum value and maximum value.Further, when range refers to integer, including the model
Each integer between minimum value and maximum value enclosed.In addition, when providing multiple range Expressive Features or characteristic, Ke Yihe
And the range.In other words, unless otherwise specified, otherwise all ranges disclosed herein are understood to include and are wherein included into
Any and all subrange.For example, should be regarded as including between minimum value 1 and maximum value 10 from the specified range of " 1 to 10 "
Any and all subrange.The Exemplary range of range 1 to 10 include but is not limited to 1 to 6.1,3.5 to 7.8,5.5 to
10 etc..
To solve the above-mentioned problems, first aspect of the present invention provides a kind of local with containing the activation of hair stroma cell
The hair restorer of agent, by weight, including 0.1-5 parts of cholesterine, 0.5-6 parts of potassium channel openers be used as effective component.
Cholesterine
In a kind of preferred embodiment, the cholesteric general structure are as follows:Wherein, R indicates the isomery alkyl of C3-C9.
Heretofore described cholesterine can be considered as a kind of extreme nonpolar dehydration product of cholesterol, and isomery alkyl is
Refer to the alkyl containing branch in molecule.
In a kind of preferred embodiment, the R indicates the isomery saturated fat alkyl of C3-C9.
In a kind of preferred embodiment, the R is C6 isomery saturated fat alkyl.
In a kind of preferred embodiment, the cholesterine is cholesteric -3,5- diene, structural formula are as follows:
Cholesteric -3,5- diene of the present invention (No. CAS is 747-90-0) is a kind of natural bioactive ingredients and steroid
Body steroids raw material, is present in the cornea of common dog, ox and people, accounts for the 20-25% of the total steroids of dog cornea, ox and people
Cornea account for 5-10%.
The present invention does not have any restrictions to the source of cholesteric -3,5- diene, separation and Extraction can obtain out of mink fat,
It can also be by being commercially available.
Potassium channel openers
Potassium channel openers of the present invention are also known as outward potassium flow and promote medicine, are a kind of antihypertensive drugs, act on machine
System is by open potassium channel, and outward potassium flow increases, and cell membrane hyperpolarization, membrane excitability reduces, Ca2+Interior stream is reduced, vascular smooth
Flesh diastole, blood pressure decline.
In a preferred embodiment, the potassium channel openers are selected from minoxidil, diazoxiide, carnitine, ox sulphur
One of acid etc. are a variety of.
In a kind of preferred embodiment, the potassium channel openers are the mixture of carnitine, taurine.
It is furthermore preferred that the carnitine, taurine weight ratio are (0.5-1): 1.
Still more preferably, the carnitine, taurine weight ratio are 0.8:1.
The applicant adds quantitative both K ~+Channel Openers of carnitine and taurine in the composition, can
Blood circulation is helped, the size of hair follicle is regulated and controled, shortens hair growth composition responding time.It is further discovered that carnitine and taurine energy
The stability for improving composition, is primarily due to carnitine and when taurine is attracted each other forms polymer, and when concentration is higher is formed
Micella increases the dissolution equilibrium of cholesteric -3,5- diene and white birch extract, system is made to become transparent.And inventor also found
When the weight ratio of carnitine, taurine is (0.5-1): when 1, not only stability is best for product, but also use feeling is excellent, and small molecule contains
The carnitine charge of nitrogen quantity is higher, and inventor avoids irritation, and additional amount will not be too many, by with white birch extract, acetyl four
Peptide -3 reduces critical micelle concentration together, makes it easier to through epidermis, then make system by the hydrogen bond association between component
It is as clear as crystal.
It in a preferred embodiment, by weight, further include 0.1-3 parts of biologically active polypeptide, white birch extraction
1-3 parts of object.
Biologically active polypeptide
In a preferred embodiment, the biologically active polypeptide is acetyl group tetrapeptide.
In a kind of preferred embodiment, the acetyl group tetrapeptide be selected from acetyl group tetrapeptide -2, acetyl group tetrapeptide -3,
Acetyl group tetrapeptide -5, acetyl group tetrapeptide -9, acetyl group tetrapeptide -11, acetyl group tetrapeptide -12, acetyl group tetrapeptide -15, acetyl group four
One of peptide -17 is a variety of.
In a kind of preferred embodiment, the acetyl group tetrapeptide is acetyl group tetrapeptide -3.
Heretofore described acetyl group tetrapeptide -3 is that can be done directly on hair follicle containing there are four the beauty polypeptide of amino acid,
It stimulates tissue to generate signal peptide, to improve hair follicle activity, promotes natural on-off cycles of hair growth.
Acetyl group tetrapeptide -3 in the present invention can be obtained by commercially available, such as commercially available obtained acetyl group tetrapeptide -3 includes
But it is not limited to be purchased from Shanghai to soft Chemical Co., Ltd..
White birch extract
White birch (scientific name: BetulaplatyphyllaSuk.) of the present invention: deciduous tree, trunk is up to 25 meters of height, and 50
It is centimetre thick.It is very beneficial to the health of human body with unique medical value, there is the pharmacological actions such as antifatigue, cough-relieving, is claimed
For " natural beer ", " forest beverage ".
White birch extract (BirchExtract) in the present invention is that extraction is dried in the leaf of white birch, dry, skin, is passed through
Steam distillation, after extracting dry material, in ethanol by extract dissolution, effectively for most skin disease,
As principal component, by ergosterol (Ergosterol), betulin (Betulin), white birch wood polyenoid triol
(Betulafolientriol) extracts such as tannin (Tanin) and 50% ethyl alcohol form.
The source of white birch extract without limitation, can be prepared, such as routinely in the present invention by general extraction methods
Extraction step includes: after taking the smooth Japanese birch bark of epidermis white that water mixing is added, by enzymolysis agent is added under thermophilic digestion,
Carry out enzymolysis and extraction, carry out fine filtering after the completion, filtrate enters evaporation concentration system thickening, by the liquid after concentration into
Enter spray drying device, obtains powder, gained powder is the white birch extract in raw material.
In a kind of preferred embodiment, the biologically active polypeptide, white birch extract, cholesteric weight ratio are
1:(1-2):(1-2)。
In a kind of preferred embodiment, the biologically active polypeptide, white birch extract, cholesteric weight ratio are
1:2.5:2.5。
Inventor has found mutually cooperate with together using white birch extract of the present invention and cholesteric -3,5- diene,
Can control hair follicle size promote hair generate, reduce alopecia, be primarily due to the parent nucleus of cholesteric -3,5- diene stereochemical structure and
Wherein CD ring is cis- condensed, makes it have very high activity, and collaboration white birch extract inhibits 5- alpha-reductase activity, inhibits
The formation of DHT reduces alopecia, but the dissolubility of the two is poor, therefore appropriate acetyl tetrapeptide -3 must be added in composition, makes second
Acyl tetrapeptide -3, white birch extract, cholesteric -3,5- diene weight ratio be 1:1.25:1.25, to improve its dissolution in water
Property, and further promote hair growth, the reason is that under the inducing action of acetyl tetrapeptide -3, together with cholesteric -3,5- diene
Collaboration promotes the synthesis of collagen III, and then increases follicle size and improve anchoring, reduces alopecia and generates, promotes hair raw
It is long.
In addition, the white birch extract in the present invention can also be obtained by commercially available, such as commercially available obtained white birch extract
It include but is not limited to be purchased from Zheng He Biotechnology Co., Ltd.
It in a preferred embodiment, by weight, further include 1-20 parts of glucan, 10-30 parts of butanediol, water
50-100 parts.
Glucan
Glucan of the present invention refers to the homotype polysaccharide formed using glucose as monosaccharide, with glucosides between glucose unit
Key connection.
In a preferred embodiment, the glucan, potassium channel openers weight ratio be (3-10): 1.
Inventor has found that potassium channel openers, which are added, can improve the stability of composition, but is easy to cause scalp at the same time
Stimulation, is easy to itch using rear scalp, so inventor is logical in adjustment glucan and potassium under the premise of to guarantee product stability
After the ratio of road opener, make its weight ratio (3-10): when 1, find scalp itch the phenomenon that disappear, inventor speculate may
The reason of be in glucan and carnitine and one timing of content of taurine, large-sized dextran polymer may be made directly to scalp
On, the taurine and carnitine of small particle, which attract each other, to be wrapped in wherein, and passes through the compatible infiltration of carnitine and scalp cells, is promoted
So that taurine and carnitine is sprawled and is quickly penetrated into horn cell on scalp and inhibit cutin increment, reduces what dandruff generated
Protective barrier can be formed on scalp simultaneously, reduces irritation.
Butanediol
Butanediol (Butylene Glycol) alias of the present invention is called: 1,3- dihydroxy butane is the one of polyalcohol
Kind, moisturizer is often done in cosmetics and solvent uses, since butanediol is small molecule moisturizing composition, so grabbing water ratio very
It is small, while also having certain bacteriostasis.
In the present invention, fatty material, organic solvent, solubilizer, concentration may further include for above-mentioned composition
Agent and gelling agent, stabilizer, foaming agent, aromatic, surfactant, ionic or nonionic emulsifier, softening agent, antioxygen
Agent, suspending agent, filler, metal ion block agent and chelating agent, preservative agent, vitamin, barrier, wetting agent, hydrophily
Or lipophilic activating agent, must be usually used in oil, fuel, lipid vesicle or cosmeceutical field adjuvant.In the present invention
In, above-mentioned cosmetic composition is absorbed into inside hair and plays the role of increasing diameter of hair.
Further, the present invention provides the skin preparations for extenal use including above-mentioned composition.
Skin preparations for extenal use including above-mentioned composition of the invention can prepare frost, gel, patch, ointment, coagulator,
Emulsion agent, liquor, emulsion, pulvis, spraying dosage form, but not limited to this.
Be frost or in the case where gel in dosage form of the invention, as carrier components can using animal origin, plant fiber,
Wax, paraffin, starch, traganth, cellulose derivative, polyethylene glycol, bentonite, silica, talcum, zinc oxide etc..
In the case where dosage form of the invention is powder or is spraying, lactose, talcum, titanium dioxide can be utilized as carrier components
Silicon, aluminium hydroxide, calcium silicates, Silon, in particular, may also include chlorofluorocarbons, propane/butane or two in the case where spraying
The propellants such as methyl ether.
Dosage form of the invention be liquor or emulsion in the case where, as carrier at using have solvent, resolvating agent or
Milkiness agent, for example, water, Ethanol Isopropanol, ethyl carbonate, ethyl acetate, benzylalcohol, Ergol, propylene glycol, 1,3- fourth two
Alcohol oil, glycerin fatty race ester, polyethylene glycol, the aliphatic ester of D-sorbite etc..
The second aspect of the present invention provides a kind of hair restorer of the above-mentioned part containing hair stroma cell activator
Preparation method, step include: that glucan is added and is placed in 50-60 DEG C of water-bath after mixing white birch extract with water and butanediol
Stirring 3-5 minutes reduces temperature to 40 DEG C hereinafter, biologically active polypeptide, cholesterine stirring 5 minutes is added later, is uniformly mixed
Potassium channel openers are added afterwards and obtain hair restorer of the part containing hair stroma cell activator.
Third aspect of the present invention provides a kind of hair restorer of the above-mentioned part containing hair stroma cell activator
Using, the composition be applied to hair oil, embellish hair essence, brighten the hair element, hair-cream liquid, trichotrophy lotion, shampoo, hair conditioner,
Treatment wax, hair-cream, trichotrophy frost, hair moisturiser, hair massage cream, pomade, hair aerosol, hair film, trichotrophy film,
Hair soap, shining shampoo milk, trichoxerosis agent, hair save inorganic agent, hair dye, hair wavy hair agent, drift hair cream, hair jelly, hair
Glaze, hair cosmetic agent, hair lacquer, hair moisturizer, hair mousse, hair spray, but not limited to this.
The present invention is specifically described below by embodiment, in addition, if without other explanations, it is raw materials used to be all
It is commercially available.
Embodiment
Embodiment 1
Embodiment 1 provides a kind of hair restorer of the part containing hair stroma cell activator, by weight, including
Following component: 0.5 part of cholesterine, 0.5 part of potassium channel openers, 0.5 part of biologically active polypeptide, 1 part of white birch extract, glucan
3 parts, 10 parts of butanediol, 50 parts of water.
The cholesterine is cholesteric -3,5- diene；
The potassium channel openers are the mixture of carnitine, taurine, and wherein carnitine, taurine weight ratio are 0.5:1；
The biologically active polypeptide is acetyl group tetrapeptide -3.
Embodiment 2
Embodiment 2 provides a kind of hair restorer of the part containing hair stroma cell activator, by weight, including
Following component: 5 parts of cholesterine, 6 parts of potassium channel openers, 3 parts of biologically active polypeptide, 3 parts of white birch extract, 20 parts of glucan,
30 parts of butanediol, 100 parts of water.
The cholesterine is cholesteric -3,5- diene；
The potassium channel openers are the mixture of carnitine, taurine, and wherein carnitine, taurine weight ratio are 1:1；
The biologically active polypeptide is acetyl group tetrapeptide -3.
Embodiment 3
Embodiment 3 provides a kind of hair restorer of the part containing hair stroma cell activator, by weight, including
Following component: 1 part of cholesterine, 0.5 part of potassium channel openers, 1 part of biologically active polypeptide, 2 parts of white birch extract, 5 parts of glucan,
15 parts of butanediol, 70 parts of water.
The cholesterine is cholesteric -3,5- diene；
The potassium channel openers are the mixture of carnitine, taurine, and wherein carnitine, taurine weight ratio are 0.5:1；
The biologically active polypeptide is acetyl group tetrapeptide -3.
Embodiment 4
Embodiment 4 provides a kind of hair restorer of the part containing hair stroma cell activator, by weight, including
Following component: 3 parts of cholesterine, 2 parts of potassium channel openers, 3 parts of biologically active polypeptide, 3 parts of white birch extract, Dextran 15 part,
25 parts of butanediol, 80 parts of water.
The cholesterine is cholesteric -3,5- diene；
The potassium channel openers are the mixture of carnitine, taurine, and wherein carnitine, taurine weight ratio are 0.8:1；
The biologically active polypeptide is acetyl group tetrapeptide -3.
Embodiment 5
Embodiment 5 provides a kind of hair restorer of the part containing hair stroma cell activator, by weight, including
Following component: 2.5 parts of cholesterine, 1 part of potassium channel openers, 2 parts of biologically active polypeptide, 2.5 parts of white birch extract, glucan 10
Part, 25 parts of butanediol, 78 parts of water.
The cholesterine is cholesteric -3,5- diene；
The potassium channel openers are the mixture of carnitine, taurine, and wherein carnitine, taurine weight ratio are 0.8:1；
The biologically active polypeptide is acetyl group tetrapeptide -3.
Comparative example 1
Comparative example 1 provides a kind of hair restorer of the part containing hair stroma cell activator, by weight, including
Following component: 0 part of cholesterine, 1 part of potassium channel openers, 2 parts of biologically active polypeptide, 2.5 parts of white birch extract, glucan 10
Part, 25 parts of butanediol, 78 parts of water.
The cholesterine is cholesteric -3,5- diene；
The potassium channel openers are the mixture of carnitine, taurine, and wherein carnitine, taurine weight ratio are 0.8:1；
The biologically active polypeptide is acetyl group tetrapeptide -3.
Comparative example 2
Comparative example 2 provides a kind of hair restorer of the part containing hair stroma cell activator, by weight, including
Following component: 2.5 parts of cholesterine, 0 part of potassium channel openers, 2 parts of biologically active polypeptide, 2.5 parts of white birch extract, glucan 10
Part, 25 parts of butanediol, 78 parts of water.
The cholesterine is cholesteric -3,5- diene；
The potassium channel openers are the mixture of carnitine, taurine, and wherein carnitine, taurine weight ratio are 0.8:1；
The biologically active polypeptide is acetyl group tetrapeptide -3.
Comparative example 3
Comparative example 3 provides a kind of hair restorer of the part containing hair stroma cell activator, by weight, including
Following component: 2.5 parts of cholesterine, 1 part of potassium channel openers, 2 parts of biologically active polypeptide, 2.5 parts of white birch extract, glucan 10
Part, 25 parts of butanediol, 78 parts of water.
The cholesterine is cholesteric -3,5- diene；
The potassium channel openers are carnitine；
The biologically active polypeptide is acetyl group tetrapeptide -3.
Comparative example 4
Comparative example 4 provides a kind of hair restorer of the part containing hair stroma cell activator, by weight, including
Following component: 2.5 parts of cholesterine, 1 part of potassium channel openers, 2 parts of biologically active polypeptide, 2.5 parts of white birch extract, glucan 10
Part, 25 parts of butanediol, 78 parts of water.
The cholesterine is cholesteric -3,5- diene；
The potassium channel openers are taurine；
The biologically active polypeptide is acetyl group tetrapeptide -3.
Comparative example 5
Comparative example 5 provides a kind of hair restorer of the part containing hair stroma cell activator, by weight, including
Following component: 2.5 parts of cholesterine, 1 part of potassium channel openers, 0 part of biologically active polypeptide, 2.5 parts of white birch extract, glucan 10
Part, 25 parts of butanediol, 78 parts of water.
The cholesterine is cholesteric -3,5- diene；
The potassium channel openers are the mixture of carnitine, taurine, and wherein carnitine, taurine weight ratio are 0.8:1；
The biologically active polypeptide is acetyl group tetrapeptide -3.
Comparative example 6
Comparative example 6 provides a kind of hair restorer of the part containing hair stroma cell activator, by weight, including
Following component: 2.5 parts of cholesterine, 1 part of potassium channel openers, 2 parts of biologically active polypeptide, 0 part of white birch extract, glucan 10
Part, 25 parts of butanediol, 78 parts of water.
The cholesterine is cholesteric -3,5- diene；
The potassium channel openers are the mixture of carnitine, taurine, and wherein carnitine, taurine weight ratio are 0.8:1；
The biologically active polypeptide is acetyl group tetrapeptide -3.
Comparative example 7
Comparative example 7 provides a kind of hair restorer of the part containing hair stroma cell activator, by weight, including
Following component: 2.5 parts of cholesterine, 1 part of potassium channel openers, 2 parts of biologically active polypeptide, 2.5 parts of white birch extract, glucan
0.1 part, 25 parts of butanediol, 78 parts of water.
The cholesterine is cholesteric -3,5- diene；
The potassium channel openers are the mixture of carnitine, taurine, and wherein carnitine, taurine weight ratio are 0.8:1；
The biologically active polypeptide is acetyl group tetrapeptide -3.
Performance evaluation
1. low-temperature stability is tested
Test method: each composition in embodiment and comparative example is placed 1 month under 0 DEG C of environment, is seen with visual
Examine the state of solution.It is evaluated according to evaluation criterion below:
Zero: not seeing apparent variation；×: observe muddy and sediment.
2. dissolubility is tested
Test method: each composition in embodiment and comparative example is placed 1 month under 15 DEG C of environment, is seen with visual
Examine the state of solution.It is evaluated according to evaluation criterion below:
Zero: solution is transparent, does not see apparent variation；×: solution is opaque, observes muddiness.
3. improvement is evaluated
Test method is as follows: composition described in embodiment and comparative example, which is respectively issued to 60 tester's tests, to be made
With to feeling that the position of scalp alopecia coats embodiment and comparative example composition product (5%) and 75% during test
Water and 20% alcohol.Every night uses 2mL, persistently using the improvement after 30 days, 30 days to alopecia, greasy, itch, furfur
Effect is monitored.It is evaluated according to evaluation criterion below:
Alopecia: no epilation remembers 0 point, and 20 piece/day of < is denoted as 1 point, 20-50 root/be denoted as 2 points day, 50/diary of > 3
Point.
Greasy: moderate 0 point of note, a small amount of (do not wash within two days and show greasy) remember 1 point, and moderate (do not wash for one day and show greasy) remembers 2 points,
Obviously (the greasy light of hair) remembers 3 points.
Itch: no itch remembers 0 point, and slight 1 point of note, moderate remembers 2 points, and severe remembers 3 points.
Furfur: no furfur remembers 0 point, and slight 1 point of note, moderate remembers 2 points, and severe remembers 3 points.
Table 1
4. normal individual trial case
Case: Mr. Wang, male, 27 years old, forehead hair sparse, scalp exposure, hair line was obvious, begins to use within 19th from December
5 product of embodiment (5%) and 75% water and 20% alcohol, every night uses 2mL, to Contrast on effect on January 5, volume
Hair starts to grow at head, and scalp is capped again.Fig. 1 is seen using cross-reference figure, and left side is December 19 before use, the right side
Side is after use on January 5.
Claims (10)
1. a kind of hair restorer of part containing hair stroma cell activator, which is characterized in that by weight, including cholesteric
0.1-5 parts of alcohol, 0.5-6 parts of potassium channel openers be used as effective component.
2. hair restorer of the part according to claim 1 containing hair stroma cell activator, which is characterized in that described
Cholesteric general structure are as follows:Wherein, R indicates the isomery alkyl of C3-C9.
3. hair restorer of the part according to claim 1 containing hair stroma cell activator, which is characterized in that described
Potassium channel openers are selected from one of minoxidil, diazoxiide, carnitine, taurine etc. or a variety of.
4. hair restorer of the part according to any one of claim 1-3 containing hair stroma cell activator, special
Sign is, further includes 0.1-3 parts of biologically active polypeptide, 1-3 parts of white birch extract by weight.
5. hair restorer of the part according to claim 4 containing hair stroma cell activator, which is characterized in that described
Biologically active polypeptide is acetyl group tetrapeptide.
6. hair restorer of the part according to claim 5 containing hair stroma cell activator, which is characterized in that described
Acetyl group tetrapeptide is selected from acetyl group tetrapeptide -2, acetyl group tetrapeptide -3, acetyl group tetrapeptide -5, acetyl group tetrapeptide -9, acetyl group tetrapeptide -
11, one of acetyl group tetrapeptide -12, acetyl group tetrapeptide -15, acetyl group tetrapeptide -17 or a variety of.
7. hair restorer of the part according to any one of claim 1-3 containing hair stroma cell activator, special
Sign is, further includes 1-20 parts of glucan, 10-30 parts of butanediol, 50-100 parts of water by weight.
8. hair restorer of the part according to claim 4 containing hair stroma cell activator, which is characterized in that described
Biologically active polypeptide, white birch extract, cholesteric weight ratio are 1:(1-2): (1-2).
9. hair restorer of the part according to claim 7 containing hair stroma cell activator, which is characterized in that described
Glucan, potassium channel openers weight ratio be (3-10): 1.
10. a kind of hair restorer of the part according to claim 1 to 9 containing hair stroma cell activator
Application, which is characterized in that the composition be applied to hair oil, embellish hair essence, brighten the hair element, hair-cream liquid, trichotrophy lotion, wash
Shampoo, hair conditioner, treatment wax, hair-cream, trichotrophy frost, hair moisturiser, hair massage cream, pomade, hair aerosol, hair
Film, trichotrophy film, hair soap, shining shampoo milk, trichoxerosis agent, hair save inorganic agent, hair dye, hair wavy hair agent,
Float hair cream, hair jelly, hair glaze, hair cosmetic agent, hair lacquer, hair moisturizer, hair mousse, hair spray.
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| CN201910496926.7A CN110075035A (en) | 2019-06-10 | 2019-06-10 | A kind of hair restorer of the part containing hair stroma cell activator |
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| CN201910496926.7A CN110075035A (en) | 2019-06-10 | 2019-06-10 | A kind of hair restorer of the part containing hair stroma cell activator |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113070159A (en) * | 2020-11-23 | 2021-07-06 | 上海理工大学 | Anti-hair-loss shower head based on residual chlorine removal principle |
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| CN102203115A (en) * | 2008-10-03 | 2011-09-28 | 利普泰股份公司 | Peptides useful in the treatment and/or care of skin, mucous membranes, scalp and/or hair and their use in cosmetic or pharmaceutical compositions |
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| CN108113896A (en) * | 2016-11-29 | 2018-06-05 | 栢祐株式会社 | As the Anti-hair loss of active ingredient or promote raw hair composition comprising sophorolipid |
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| CN109568169A (en) * | 2019-01-22 | 2019-04-05 | 宇肽生物(东莞)有限公司 | Active polypeptide with hair growth effect |
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| CN1128139A (en) * | 1994-06-20 | 1996-08-07 | 田边制药株式会社 | Hair-growing agent |
| CN102203115A (en) * | 2008-10-03 | 2011-09-28 | 利普泰股份公司 | Peptides useful in the treatment and/or care of skin, mucous membranes, scalp and/or hair and their use in cosmetic or pharmaceutical compositions |
| CN105106028A (en) * | 2015-08-28 | 2015-12-02 | 深圳市维琪医药研发有限公司 | Polypeptide composition for hair growth |
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