CN110074988A - The composition of a kind of anti-dentine hypersensitivity and pre- anti-caries and oral care product comprising the composition - Google Patents
The composition of a kind of anti-dentine hypersensitivity and pre- anti-caries and oral care product comprising the composition Download PDFInfo
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- CN110074988A CN110074988A CN201910506613.5A CN201910506613A CN110074988A CN 110074988 A CN110074988 A CN 110074988A CN 201910506613 A CN201910506613 A CN 201910506613A CN 110074988 A CN110074988 A CN 110074988A
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- sodium
- caries
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- dentine hypersensitivity
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- 201000002170 dentin sensitivity Diseases 0.000 title claims abstract description 47
- 239000000203 mixture Substances 0.000 title claims abstract description 46
- 230000000675 anti-caries Effects 0.000 title claims abstract description 38
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 81
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims abstract description 70
- 235000012241 calcium silicate Nutrition 0.000 claims abstract description 52
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 51
- 239000011734 sodium Substances 0.000 claims abstract description 51
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 51
- ZQBZAOZWBKABNC-UHFFFAOYSA-N [P].[Ca] Chemical compound [P].[Ca] ZQBZAOZWBKABNC-UHFFFAOYSA-N 0.000 claims abstract description 42
- 239000005018 casein Substances 0.000 claims abstract description 42
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims abstract description 42
- 235000021240 caseins Nutrition 0.000 claims abstract description 42
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 39
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 38
- 229910000389 calcium phosphate Inorganic materials 0.000 claims abstract description 38
- 235000011010 calcium phosphates Nutrition 0.000 claims abstract description 38
- 235000013024 sodium fluoride Nutrition 0.000 claims abstract description 35
- 239000011775 sodium fluoride Substances 0.000 claims abstract description 35
- 238000002360 preparation method Methods 0.000 claims abstract description 13
- 239000000606 toothpaste Substances 0.000 claims abstract description 10
- 229940034610 toothpaste Drugs 0.000 claims abstract description 10
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 27
- 229920002125 Sokalan® Polymers 0.000 claims description 27
- 229960001631 carbomer Drugs 0.000 claims description 27
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 18
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 11
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 9
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 claims description 9
- -1 ethyl alcohol Amine Chemical class 0.000 claims description 9
- 229940085605 saccharin sodium Drugs 0.000 claims description 9
- 239000000377 silicon dioxide Substances 0.000 claims description 9
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 8
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 7
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 6
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 6
- 239000000084 colloidal system Substances 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 238000011049 filling Methods 0.000 claims description 6
- 229940041616 menthol Drugs 0.000 claims description 6
- 238000007789 sealing Methods 0.000 claims description 6
- 230000008961 swelling Effects 0.000 claims description 6
- 238000010791 quenching Methods 0.000 claims description 5
- 230000000171 quenching effect Effects 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 210000004556 brain Anatomy 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Natural products CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 235000019441 ethanol Nutrition 0.000 claims 2
- 244000246386 Mentha pulegium Species 0.000 claims 1
- 235000016257 Mentha pulegium Nutrition 0.000 claims 1
- 235000004357 Mentha x piperita Nutrition 0.000 claims 1
- 238000003682 fluorination reaction Methods 0.000 claims 1
- 235000001050 hortel pimenta Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000004513 sizing Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 15
- 210000005239 tubule Anatomy 0.000 abstract description 9
- 238000000034 method Methods 0.000 abstract description 6
- 230000002045 lasting effect Effects 0.000 abstract description 5
- 230000003185 calcium uptake Effects 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 3
- 230000001680 brushing effect Effects 0.000 abstract description 2
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 229960001714 calcium phosphate Drugs 0.000 description 29
- 235000011187 glycerol Nutrition 0.000 description 18
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 9
- 239000011574 phosphorus Substances 0.000 description 9
- 229910052698 phosphorus Inorganic materials 0.000 description 9
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 8
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 7
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 6
- 229960005069 calcium Drugs 0.000 description 6
- 239000011575 calcium Substances 0.000 description 6
- 229910052791 calcium Inorganic materials 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 229910019142 PO4 Inorganic materials 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 5
- 239000006072 paste Substances 0.000 description 5
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 5
- 239000010452 phosphate Substances 0.000 description 5
- 230000035945 sensitivity Effects 0.000 description 5
- 229940031098 ethanolamine Drugs 0.000 description 4
- 210000000214 mouth Anatomy 0.000 description 4
- 241000194019 Streptococcus mutans Species 0.000 description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000005115 demineralization Methods 0.000 description 3
- 230000002328 demineralizing effect Effects 0.000 description 3
- 208000002925 dental caries Diseases 0.000 description 3
- 210000003298 dental enamel Anatomy 0.000 description 3
- 210000004268 dentin Anatomy 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 240000002853 Nelumbo nucifera Species 0.000 description 2
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 2
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 2
- 108010001441 Phosphopeptides Proteins 0.000 description 2
- ABCWLNFYJOPDBF-UHFFFAOYSA-N [Na].[P].[Ca] Chemical compound [Na].[P].[Ca] ABCWLNFYJOPDBF-UHFFFAOYSA-N 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- 239000000378 calcium silicate Substances 0.000 description 2
- 229910052918 calcium silicate Inorganic materials 0.000 description 2
- 230000001013 cariogenic effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 229910052587 fluorapatite Inorganic materials 0.000 description 2
- 229940077441 fluorapatite Drugs 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000005342 ion exchange Methods 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 229940090898 Desensitizer Drugs 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 244000060234 Gmelina philippensis Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical class [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 1
- 201000004328 Pulpitis Diseases 0.000 description 1
- 206010037464 Pulpitis dental Diseases 0.000 description 1
- VEUACKUBDLVUAC-UHFFFAOYSA-N [Na].[Ca] Chemical compound [Na].[Ca] VEUACKUBDLVUAC-UHFFFAOYSA-N 0.000 description 1
- JOXCDOKKASTCHR-UHFFFAOYSA-N [Si](O)(O)(O)O.[P] Chemical compound [Si](O)(O)(O)O.[P] JOXCDOKKASTCHR-UHFFFAOYSA-N 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- UUVBYOGFRMMMQL-UHFFFAOYSA-N calcium;phosphoric acid Chemical compound [Ca].OP(O)(O)=O UUVBYOGFRMMMQL-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000000586 desensitisation Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 150000004673 fluoride salts Chemical class 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
- 150000003385 sodium Chemical class 0.000 description 1
- ZBFCVKZIVHEDOE-UHFFFAOYSA-M sodium;propane-1,2,3-triol;fluoride Chemical compound [F-].[Na+].OCC(O)CO ZBFCVKZIVHEDOE-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to the composition of a kind of anti-dentine hypersensitivity and pre- anti-caries and comprising the oral care product of the composition, belong to oral care techniques field.To solve the problems, such as that existing anti-dentine hypersensitivity curative effect of medication is not lasting and has a single function, the present invention provides a kind of anti-dentine hypersensitivity and the compositions of pre- anti-caries, include following component: sodium fluoride, phosphorus calcium silicates sodium, the unformed calcium phosphate of casein phosphopeptide-and glycerol.Composition provided by the invention can close or reduce dentinal tubule, promote calcium uptake activity, and the double effects of anti-caries can be realized while antiallergic sense.The present invention provides toothpaste and desensitizing dental gel containing anti-dentine hypersensitivity and the composition of pre- anti-caries, it can be by acting differently on tooth, dentine hypersensitivity and pre- anti-caries are treated while brushing teeth or oral care, and oral care product preparation process provided by the invention is simple, non-aqueous techniques, processing cost is low, is highly susceptible to promotion and implementation.
Description
Technical field
The invention belongs to oral care techniques field more particularly to the compositions of a kind of anti-dentine hypersensitivity and pre- anti-caries
And the oral care product comprising the composition.
Background technique
Dentine hypersensitivity refers to that exposed dentine generates short and sharp pain to environmental stimuli, and cannot be attributed to
Defect of teeth caused by other specific reasons or lesion, typical stimulation include thermal stimulus, stimulation of blowing, mechanical irritation or
Chemical stimulation.China's dentine hypersensitivity epidemiological survey is as the result is shown: the detection of dentine hypersensitivity in 20~60 years old adult
Rate is 29.7%, and high incidence age group is 50~59 years old age group, and women is higher than male.
Dental caries are commonly called as decayed tooth, decayed tooth, are bacteriosis, can be with secondary pulpitis and periapical inflammation, or even can cause tooth
Slot bone and inflammation of jaws.It is such as not treated in time, lesion continues to develop, and forms cavity, destroys disappearance completely to corona eventually, develops
Final result be loss of tooth.The characteristics of dental caries is that disease incidence is high, distribution is wide, is the main common disease in oral cavity and the mankind
It is listed as the big keypoint control disease of the mankind three with tumour and cardiovascular disease by one of most common disease, the World Health Organization
Disease.
Currently, clinically common anti-dentine hypersensitivity drug has fluorides, sylvite class and compound desensitizer etc., but more
Number can only respite pain, curative effect is not lasting, and function is relatively single, cannot combine anti-dentine hypersensitivity and pre- preventing decayed tooth
Tooth.
Summary of the invention
To solve the problems, such as that existing anti-dentine hypersensitivity curative effect of medication is not lasting and has a single function, the present invention provides one kind
The composition of anti-dentine hypersensitivity and pre- anti-caries and oral care product comprising the composition.
Technical solution of the present invention:
A kind of composition of anti-dentine hypersensitivity and pre- anti-caries, the component comprising following parts by weight: sodium fluoride 0.1~
1.5 parts, 3~7 parts of phosphorus calcium silicates sodium, 5~20 parts and 50~80 parts of glycerol of the unformed calcium phosphate of casein phosphopeptide-.
Further, the component including following parts by weight: 1.0 parts of sodium fluoride, 5 parts of phosphorus calcium silicates sodium, casein phosphoric acid are more
15 parts and 70 parts of glycerol of the unformed calcium phosphate of peptide-.
Further, the phosphorus calcium silicates sodium the preparation method comprises the following steps: weighing SiO by weight240~50 parts, CaO 15~
25 parts, K21~30 part of O and P2O54~6 parts, 60~90min is melted at a temperature of each component mixing is placed on 1400~1500 DEG C
Obtain uniform mixture, the mixture, which is placed in room temperature water-bath, makes its quenching, be ground to after drying partial size be 10~
The particle of 50nm to get arrive the phosphorus calcium silicates sodium.
A kind of oral care product of the composition comprising anti-dentine hypersensitivity and pre- anti-caries, the oral care product
For toothpaste, the component comprising following parts by weight:
0.1~1.5 part of sodium fluoride, 3~7 parts of phosphorus calcium silicates sodium, 5~20 parts of the unformed calcium phosphate of casein phosphopeptide-,
50~80 parts of glycerol, 0.5~1.5 part of carbomer, 0.1~1.5 part of saccharin sodium, PEG4005~15 part, triethanolamine 0.5~1.5
Part, 5~15 parts of silica, 1~1.5 part of lauryl sodium sulfate and 0.1~0.5 part of menthol.
Further, the oral care product be toothpaste, the component comprising following parts by weight:
0.3 part of sodium fluoride, 5 parts of phosphorus calcium silicates sodium, 9 parts of the unformed calcium phosphate of casein phosphopeptide-, 62 parts of glycerol, card
0.8 part of wave nurse, 0.1 part of saccharin sodium, PEG40010 parts, 0.5 part of triethanolamine, 1 part of silica 1,1 part of lauryl sodium sulfate
With 0.3 part of menthol.
Further, the preparation process of the toothpaste are as follows:
Carbomer is dissolved in glycerol, is heated to 40~50 DEG C, and homogenizer homogeneous makes carbomer complete swelling；By PEG400, three
Ethanol amine is added in carbomer colloid, and sodium fluoride, lauryl sodium sulfate, saccharin sodium, thin is added in homogenizer after five minutes
Lotus brain, phosphorus calcium silicates sodium, casein phosphopeptide-unformed calcium phosphate are added three times silica simultaneously after homogeneous 30 minutes
It stirs evenly, after homogeneous 15 minutes, stirring 1h is vacuumized under conditions of pressure is -0.08Mpa ± 0.01Mpa, homogeneous 3 divides
Clock stirs 5 minutes after basin, is repeated 5 times rear filling, sealing.
A kind of oral care product of the composition comprising anti-dentine hypersensitivity and pre- anti-caries, the oral care product
For desensitizing dental gel, the component comprising following parts by weight:
0.1~1.5 part of sodium fluoride, 3~7 parts of phosphorus calcium silicates sodium, 5~20 parts of the unformed calcium phosphate of casein phosphopeptide-,
50~80 parts of glycerol, 0.5~1.5 part of carbomer, PEG4005~15 part and 0.5~1.5 part of triethanolamine.
Further, the oral care product be desensitizing dental gel, the component comprising following parts by weight:
0.5 part of sodium fluoride, 4.5 parts of phosphorus calcium silicates sodium, 10 parts of the unformed calcium phosphate of casein phosphopeptide-, 75 parts of glycerol,
0.8 part, PEG40010 parts and 0.5 part of triethanolamine of carbomer.
Further, the preparation process of the desensitizing dental gel are as follows:
Carbomer is dissolved in glycerol, is heated to 40~50 DEG C, and homogenizer homogeneous makes carbomer complete swelling；By PEG400, three
Ethanol amine is added in carbomer colloid, and it is more that sodium fluoride, phosphorus calcium silicates sodium, casein phosphoric acid is added in homogenizer after five minutes
Peptide-unformed calcium phosphate after homogeneous 30 minutes, vacuumizes stirring 1h, under conditions of pressure is -0.08Mpa ± 0.01Mpa
It matter 3 minutes, is stirred 5 minutes after basin, is repeated 5 times rear filling, sealing.
Beneficial effects of the present invention:
Dentinal tubule can be closed or be reduced to anti-dentine hypersensitivity provided by the invention and the composition of pre- anti-caries, hold
Continuous release calcium, phosphate anion simultaneously deposit it in dental surface, generate hydroxyapatite, cover and close off dentinal tubule,
The unformed calcium phosphate of casein phosphopeptide-has very strong promotion calcium uptake activity, can inhibit enamel demineralization and promote its mine again
Change, each component, which mutually acts synergistically, further improves the effect for the treatment of dentine hypersensitivity.Better antibacterial is also reached simultaneously
Effect, antibacterial action maximum amplification can inhibit the life for causing cariogenic hedgehog fungus while treating dentine hypersensitivity up to 464%
It is long, the double effects of pre- anti-caries are realized while anti-dentine hypersensitivity.
Anti- dentine hypersensitivity provided by the invention and the composition of pre- anti-caries can be widely applied to anti-dentine hypersensitivity and
In the various oral care products of pre- anti-caries, the present invention provides the compositions containing anti-dentine hypersensitivity and pre- anti-caries
Toothpaste and desensitizing dental gel can treat tooth sheet by acting differently on tooth while brushing teeth or oral care
Matter sensitivity and pre- anti-caries, and oral care product preparation process provided by the invention is simple, non-aqueous techniques, processing cost is low,
It is highly susceptible to promotion and implementation.
Specific embodiment
Below with reference to embodiment, the following further describes the technical solution of the present invention, and however, it is not limited to this, all right
Technical solution of the present invention is modified or replaced equivalently, and without departing from the spirit and scope of the technical solution of the present invention, should all be contained
Lid is within the protection scope of the present invention.
Embodiment 1
Present embodiments provide the composition of a kind of anti-dentine hypersensitivity and pre- anti-caries, the group comprising following parts by weight
Point: 0.1~1.5 part of sodium fluoride, 3~7 parts of phosphorus calcium silicates sodium, 5~20 parts of the unformed calcium phosphate of casein phosphopeptide-, glycerol
50~80 parts.
Glycerol is solvent in composition provided in this embodiment, prevents moisture in lotion from escaping, while increasing lotion
Cold resistance, product property are stablized, nontoxic corrosion-free, extensive food, cosmetics；The mechanism of sodium fluoride is that fluorine ion may penetrate into tooth
In essence in conjunction with calcium salt, forms fluor-apatite closing dentinal tubule or reduce the diameter of dentinal tubule, to play
Alleviate the effect of dentine hypersensitivity；Ion exchange, sustained release occur in one minute for phosphorus calcium silicates sodium and water and ptyaloreaction
Calcium, phosphate anion increase oral cavity partial pH value temporarily, further material and calcium in saliva and phosphate anion are promoted to exist
Dental surface deposition, with the lasting progress of reaction, Ca-P compound is constantly deposited, and sedimentary, which gradually crystallizes, generates hydroxy-apatite
Stone, remaining phosphorus calcium silicates sodium particle and hydroxyapatite mixing covering closing dentinal tubule, play treatment dentine hypersensitivity,
The effect of pre- anti-caries.
Casein phosphopeptide be using bovine casein as raw material, it is biologically active more as made from biotechnology
Peptide, the surface that it can be adhered to unformed calcium phosphate form micro- cluster casein phosphopeptide-unformed calcium phosphate complex, have very
Strong rush calcium uptake can inhibit enamel demineralization and promote its remineralization.Compared with fluoride, safety is higher, is a kind of
Safely and effectively preventing decayed tooth preparation can effectively improve the inhibiting effect for cariogenic bacteria, can make an addition to food and oral health produces
In product.The present invention, which adds the unformed calcium phosphate of casein phosphopeptide-, can reduce the ratio of fluoride, improve desensitization, preventing decayed tooth
While effect, fluoride bring security risk is reduced.
Embodiment 2
Present embodiments provide the composition of a kind of anti-dentine hypersensitivity and pre- anti-caries, the group including following parts by weight
Point: 1.0 parts of sodium fluoride, 5 parts of phosphorus calcium silicates sodium, 15 parts, 70 parts of glycerol of the unformed calcium phosphate of casein phosphopeptide-.
Embodiment 3
Present embodiments provide a kind of phosphorus calcium silicates sodium the preparation method comprises the following steps: weighing SiO by weight240~50 parts,
CaO15~25 part, K21~30 part of O and P2O54~6 parts, each component mixing is placed at a temperature of 1400~1500 DEG C and melts 60
~90min obtains uniform mixture, and the mixture, which is placed in room temperature water-bath, makes its quenching, is ground to partial size after drying and is
The particle of 10~50nm to get arrive the phosphorus calcium silicates sodium.
Embodiment 4
A kind of toothpaste of composition comprising anti-dentine hypersensitivity and pre- anti-caries is present embodiments provided, following weight is included
Measure the component of part:
0.1~1.5 part of sodium fluoride, 3~7 parts of phosphorus calcium silicates sodium, 5~20 parts of the unformed calcium phosphate of casein phosphopeptide-,
50~80 parts of glycerol, 0.5~1.5 part of carbomer, 0.1~1.5 part of saccharin sodium, PEG4005~15 part, triethanolamine 0.5~1.5
Part, 5~15 parts of silica, 1~1.5 part of lauryl sodium sulfate, 0.1~0.5 part of menthol.
Embodiment 5
A kind of toothpaste of composition comprising anti-dentine hypersensitivity and pre- anti-caries is present embodiments provided, following weight is included
Measure the component of part:
0.3 part of sodium fluoride, 5 parts of phosphorus calcium silicates sodium, 9 parts of the unformed calcium phosphate of casein phosphopeptide-, 62 parts of glycerol, card
0.8 part of wave nurse, 0.1 part of saccharin sodium, PEG40010 parts, 0.5 part of triethanolamine, 1 part of silica 1, lauryl sodium sulfate 1
Part, 0.3 part of menthol.
Embodiment 6
This implementation provides a kind of preparation process of the toothpaste of composition comprising anti-dentine hypersensitivity and pre- anti-caries are as follows:
Carbomer is dissolved in glycerol, is heated to 40~50 DEG C, and homogenizer homogeneous makes carbomer complete swelling；By PEG400, three
Ethanol amine is added in carbomer colloid, and sodium fluoride, lauryl sodium sulfate, saccharin sodium, thin is added in homogenizer after five minutes
Lotus brain, phosphorus calcium silicates sodium, casein phosphopeptide-unformed calcium phosphate are added three times silica simultaneously after homogeneous 30 minutes
It stirs evenly, after homogeneous 15 minutes, stirring 1h is vacuumized under conditions of pressure is -0.08Mpa ± 0.01Mpa, homogeneous 3 divides
Clock stirs 5 minutes after basin, is repeated 5 times rear filling, sealing.
Phosphorus calcium silicates sodium the preparation method comprises the following steps: weighing SiO by weight in the present embodiment242 parts, 20 parts of CaO, K2O 15
Part and P2O55 parts, fusing 70min obtains uniform mixture at a temperature of each component mixing is placed on 1450 DEG C, by the mixing
Object, which is placed in room temperature water-bath, makes its quenching, and the particle that partial size is 10~50nm is ground to after drying to get the phosphorus calcium silicates is arrived
Sodium.
Embodiment 7
A kind of desensitizing dental gel of composition comprising anti-dentine hypersensitivity and pre- anti-caries is present embodiments provided, is wrapped
Component containing following parts by weight:
0.1~1.5 part of sodium fluoride, 3~7 parts of phosphorus calcium silicates sodium, 5~20 parts of the unformed calcium phosphate of casein phosphopeptide-,
50~80 parts of glycerol, 0.5~1.5 part of carbomer, PEG4005~15 part, 0.5~1.5 part of triethanolamine.
Embodiment 8
A kind of desensitizing dental gel of composition comprising anti-dentine hypersensitivity and pre- anti-caries is present embodiments provided, is wrapped
Component containing following parts by weight:
0.5 part of sodium fluoride, 4.5 parts of phosphorus calcium silicates sodium, 10 parts of the unformed calcium phosphate of casein phosphopeptide-, 75 parts of glycerol,
0.8 part of carbomer, PEG40010 parts, 0.5 part of triethanolamine.
Embodiment 9
The present invention provides a kind of systems of the desensitizing dental gel of composition comprising anti-dentine hypersensitivity and pre- anti-caries
Standby technique are as follows:
Carbomer is dissolved in glycerol, is heated to 40~50 DEG C, and homogenizer homogeneous makes carbomer complete swelling；By PEG400, three
Ethanol amine is added in carbomer colloid, and it is more that sodium fluoride, phosphorus calcium silicates sodium, casein phosphoric acid is added in homogenizer after five minutes
Peptide-unformed calcium phosphate after homogeneous 30 minutes, vacuumizes stirring 1h, under conditions of pressure is -0.08Mpa ± 0.01Mpa
It matter 3 minutes, is stirred 5 minutes after basin, is repeated 5 times rear filling, sealing.
Phosphorus calcium silicates sodium the preparation method comprises the following steps: weighing SiO by weight in the present embodiment244 parts, 23 parts of CaO, K2O 20
Part and P2O54 parts, fusing 80min obtains uniform mixture at a temperature of each component mixing is placed on 1450 DEG C, by the mixing
Object, which is placed in room temperature water-bath, makes its quenching, and the particle that partial size is 10~50nm is ground to after drying to get the phosphorus calcium silicates is arrived
Sodium.
Experimental example one: anti-caries effect experiment
1) common pathogenic bacteria of decayed tooth streptococcus mutans strain is chosen in experiment, carries out secondary culture, forms streptococcus mutans bacterium
Group, streptococcus mutans bacterium solution of the dilution in logarithmic phase to 1.0 × 1060.1ml will be added dropwise on 24 orifice plates sterilized in CFU/mL
24 orifice plates are put into 37 DEG C of anaerobic culture box and cultivated 24 hours, are during which added without fresh medium by bacterium solution.
2) the raw material fluorinated sodium of 0.1g, phosphorus calcium silicates sodium, the unformed calcium phosphate of casein phosphopeptide-are taken, respectively with single
Sodium fluoride, single phosphorus calcium silicates sodium, the unformed calcium phosphate of single casein phosphopeptide-, sodium fluoride+phosphorus calcium silicates sodium compounding with
And sodium fluoride+phosphorus calcium silicates sodium+unformed calcium phosphate formulation agents of casein phosphopeptide-are respectively dropped into and are completed the 24 of culture
Orifice plate carries out bacteriostatic test, and the percentage of practical number of bacteria reduction is as shown in table 1 in the case of logarithm:
Table 1
| Name of product | Number of bacteria reduces percentage % |
| Sodium fluoride | 2.43 |
| Phosphorus calcium silicates sodium | 12.89 |
| The unformed calcium phosphate of casein phosphopeptide- | 5.32 |
| Sodium fluoride+phosphorus calcium silicates sodium | 21.33 |
| Sodium fluoride+phosphorus calcium silicates sodium+unformed calcium phosphate of casein phosphopeptide- | 30.75 |
From the data in table 1, it can be seen that sodium fluoride+phosphorus calcium silicates sodium+unformed calcium phosphate formulation agents of casein phosphopeptide-
Fungistatic effect is best.This is because the addition of fluorine ion can be improved the antibacterial effect of phosphorus calcium silicates sodium, sodium fluoride and phosphorus silicic acid
The use in conjunction of the unformed calcium phosphate of calcium sodium, casein phosphopeptide-is more preferable to the antibacterial action effect of bacterium, and antibacterial action is most
Big amplification is up to 464%.
Experimental example two: anti-dentine hypersensitivity experiment
Choose the patient 100 (male 53/female 47) that Outpatient Service Stomatology is collected, the age 26-75 years old, no dental caries, without crack, not
Do fill suffer from tooth totally 160, through visit examine, cold examine is confirmed as dental hypersensitiveness.100 patients are randomly divided into 4 groups, every group
25 people, using the straight line of a 10cm long, it is 0 that one end, which indicates " without pain ", which scores, and the other end indicates " pain can not endure " note
It is divided into 10, it is desirable that dental hypersensitiveness patient marks the sensitivity of tooth at that time on straight line.To treat predentin's allergy
The sensitivity of patient is radix, and sensitivity reduces by 2/3 the above are effective after treatment, and reducing by 2/3~1/3 be effective, deficiency
1/3 is invalid.
First group with sodium fluoride glycerine paste, second group uses phosphorus sodium calcium silicate glycerol paste, and third group uses casein
The unformed Calciumphosphate paste of polypeptide phosphate-, the 4th group use sodium fluoride+phosphorus calcium silicates sodium+unformed phosphorus of casein phosphopeptide-
Sour calcium mixing paste.
Four groups of dental hypersensitiveness patients check sensitive spot with probe and cold air before the treatment, record sensitivity,
Cleaning treatment facing, every wet, drying.It dips aforesaid paste respectively with cotton pellet and is wiped repeatedly sensitizing range 1-2min, be repeated twice
Wiping re-starts detection after treatment 15 minutes.Pretherapy and post-treatment Contrast on effect is shown in Table 2.
Table 2
| Group | n | It is effective | Effectively | In vain | Total effective rate |
| First group | 25 | 5 | 10 | 10 | 60% |
| Second group | 25 | 6 | 11 | 8 | 68% |
| Third group | 25 | 8 | 8 | 9 | 64% |
| 4th group | 25 | 12 | 10 | 3 | 88% |
Sodium fluoride+phosphorus calcium silicates sodium+unformed phosphoric acid calcium phase of casein phosphopeptide-it can be seen from 2 data comparison of table
Compounding, three kinds of components can play synergistic effect, and fluorine ion may penetrate into dentine in conjunction with calcium salt, form fluor-apatite envelope
Closing tubules or the diameter for reducing dentinal tubule, to play the role of alleviating dentine hypersensitivity；Fluorine ion also can
Enough phosphorus sodium calcium silicate is promoted to generate remineralization substance, achievees the purpose that faster to treat hypersensitive dentin.Phosphorus calcium silicates sodium and water and
Ion exchange occurs in one minute for ptyaloreaction, and sustained release calcium, phosphate anion increase oral cavity partial pH value temporarily,
Further material and calcium in saliva and phosphate anion is promoted to deposit in dental surface, with the lasting progress of reaction, Ca-P
Compound constantly deposits, and sedimentary, which gradually crystallizes, generates hydroxyapatite, remaining phosphorus calcium silicates sodium particle and hydroxyapatite
Mixing covering closing dentinal tubule；At the same time, the surface that casein phosphopeptide can be adhered to unformed calcium phosphate is formed
Micro- cluster casein phosphopeptide-unformed calcium phosphate complex has very strong rush calcium uptake, can inhibit enamel demineralization and promote
Its remineralization plays the role of more efficient treatment dentine hypersensitivity, pre- anti-caries.
Claims (9)
1. the composition of a kind of anti-dentine hypersensitivity and pre- anti-caries, which is characterized in that the component comprising following parts by weight: fluorination
0.1~1.5 part of sodium, 3~7 parts of phosphorus calcium silicates sodium, 5~20 parts of the unformed calcium phosphate of casein phosphopeptide-and glycerol 50~80
Part.
2. a kind of anti-dentine hypersensitivity and the composition of pre- anti-caries according to claim 1, which is characterized in that including as follows
The component of parts by weight: 1.0 parts of sodium fluoride, 5 parts of phosphorus calcium silicates sodium, 15 parts of the unformed calcium phosphate of casein phosphopeptide-and glycerol
70 parts.
3. the composition of a kind of anti-dentine hypersensitivity according to claim 1 or claim 2 and pre- anti-caries, which is characterized in that described
Phosphorus calcium silicates sodium weighs SiO the preparation method comprises the following steps: weighing by weight240~50 parts, 15~25 parts of CaO, K21~30 part of O
And P2O54~6 parts, 60~90min of fusing obtains uniform mixing at a temperature of each component mixing is placed on 1400~1500 DEG C
Object, the mixture, which is placed in room temperature water-bath, makes its quenching, and the particle that partial size is 10~50nm is ground to after drying to get arriving
The phosphorus calcium silicates sodium.
4. a kind of oral care product of the composition comprising anti-dentine hypersensitivity and pre- anti-caries, which is characterized in that the mouth
Chamber care product be toothpaste, the component comprising following parts by weight:
0.1~1.5 part of sodium fluoride, 3~7 parts of phosphorus calcium silicates sodium, 5~20 parts of the unformed calcium phosphate of casein phosphopeptide-, glycerol
50~80 parts, 0.5~1.5 part of carbomer, 0.1~1.5 part of saccharin sodium, 5~15 parts of PEG400,0.5~1.5 part of triethanolamine,
5~15 parts of silica, 1~1.5 part of lauryl sodium sulfate and 0.1~0.5 part of menthol.
5. a kind of oral care product of the composition comprising anti-dentine hypersensitivity and pre- anti-caries according to claim 4,
It is characterized in that, the component comprising following parts by weight:
0.3 part of sodium fluoride, 5 parts of phosphorus calcium silicates sodium, 9 parts of the unformed calcium phosphate of casein phosphopeptide-, 62 parts of glycerol, carbomer
0.8 part, 0.1 part of saccharin sodium, 10 parts of PEG400,0.5 part of triethanolamine, 1 part of silica 1,1 part of lauryl sodium sulfate and
0.3 part of menthol.
6. a kind of oral care of composition comprising anti-dentine hypersensitivity and pre- anti-caries according to claim 4 or 5 produces
Product, which is characterized in that the preparation process of the toothpaste are as follows:
Carbomer is dissolved in glycerol, is heated to 40~50 DEG C, and homogenizer homogeneous makes carbomer complete swelling；By PEG400, three ethyl alcohol
Amine is added in carbomer colloid, and sodium fluoride, lauryl sodium sulfate, saccharin sodium, peppermint is added in homogenizer after five minutes
Brain, phosphorus calcium silicates sodium, casein phosphopeptide-unformed calcium phosphate are added three times silica and stir after homogeneous 30 minutes
It mixes uniformly, after homogeneous 15 minutes, is vacuumized under conditions of pressure is -0.08Mpa ± 0.01Mpa and stir 1h, homogeneous 3 minutes,
It is stirred 5 minutes after basin, is repeated 5 times rear filling, sealing.
7. a kind of oral care product of the composition comprising anti-dentine hypersensitivity and pre- anti-caries, which is characterized in that the mouth
Chamber care product be desensitizing dental gel, the component comprising following parts by weight:
0.1~1.5 part of sodium fluoride, 3~7 parts of phosphorus calcium silicates sodium, 5~20 parts of the unformed calcium phosphate of casein phosphopeptide-, glycerol
50~80 parts, 0.5~1.5 part of carbomer, 5~15 parts of PEG400 and 0.5~1.5 part of triethanolamine.
8. a kind of oral care product of the composition comprising anti-dentine hypersensitivity and pre- anti-caries according to claim 7,
It is characterized in that, the oral care product be desensitizing dental gel, the component comprising following parts by weight:
0.5 part of sodium fluoride, 4.5 parts of phosphorus calcium silicates sodium, 10 parts of the unformed calcium phosphate of casein phosphopeptide-, 75 parts of glycerol, card wave
0.8 part of nurse, 10 parts of PEG400 and 0.5 part of triethanolamine.
9. according to a kind of oral care production of the composition comprising anti-dentine hypersensitivity and pre- anti-caries of claim 7 or 8
Product, which is characterized in that the preparation process of the desensitizing dental gel are as follows:
Carbomer is dissolved in glycerol, is heated to 40~50 DEG C, and homogenizer homogeneous makes carbomer complete swelling；By PEG400, three ethyl alcohol
Amine is added in carbomer colloid, and sodium fluoride, phosphorus calcium silicates sodium, casein phosphopeptide-nothing is added in homogenizer after five minutes
Sizing calcium phosphate after homogeneous 30 minutes, vacuumizes stirring 1h under conditions of pressure is -0.08Mpa ± 0.01Mpa, and homogeneous 3 divides
Clock stirs 5 minutes after basin, is repeated 5 times rear filling, sealing.
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