CN109939358B - Low-frequency-band broadband magnetic field therapeutic apparatus for tumor treatment and application method thereof - Google Patents
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Abstract
本发明涉及一种用于肿瘤治疗的低频段宽频带磁场治疗仪及其应用方法，主要应用于医疗领域。由上位机经主控单元、多通道宽频信号发生单元、信号调理单元、功率放大单元与亥姆霍兹线圈组连接，主控单元分别与信号调理单元、功率放大单元连接，磁场测量单元以及温度反馈单元分别与上位机连接，磁场测量单元经PID反馈调节单元与主控单元连接组成。本发明所涉及的磁场治疗仪的频带覆盖0.1Hz‑300Hz的低频段，操作便捷，磁场方向及大小可控，应用时无需事先对不同肿瘤的最佳磁场抑制频率进行研究，既节约时间，避免了由于磁场频率特异性引起的疗效不佳，又提高了效率，增加了磁场疗法应用于不同肿瘤的普适性，可对多种肿瘤有显著的抑制作用。
The invention relates to a low-frequency broadband magnetic field therapeutic apparatus for tumor treatment and an application method thereof, which are mainly applied in the medical field. The host computer is connected to the Helmholtz coil group via the main control unit, the multi-channel broadband signal generating unit, the signal conditioning unit and the power amplifying unit. The main control unit is respectively connected with the signal conditioning unit, the power amplifying unit, the magnetic field measuring unit and the temperature The feedback unit is respectively connected with the host computer, and the magnetic field measurement unit is connected with the main control unit through the PID feedback adjustment unit. The frequency band of the magnetic field therapy instrument involved in the present invention covers the low frequency band of 0.1Hz-300Hz, the operation is convenient, the direction and size of the magnetic field are controllable, and the optimal magnetic field suppression frequency for different tumors does not need to be studied in advance during application, which not only saves time, avoids In addition to the poor curative effect caused by the frequency specificity of the magnetic field, the efficiency is improved, the universality of the magnetic field therapy applied to different tumors is increased, and it can have a significant inhibitory effect on a variety of tumors.
Description
技术领域technical field
本发明涉及磁场治疗仪领域，尤其是一种用于肿瘤治疗的低频段宽频带磁场治疗仪及其应用方法。The invention relates to the field of magnetic field therapeutic apparatus, in particular to a low-frequency broadband magnetic field therapeutic apparatus for tumor treatment and an application method thereof.
背景技术Background technique
肿瘤是机体在各种致瘤因素的作用下，局部组织的细胞在基因水平上失去了对其生长的正常调控，导致异常增生而形成的赘生物。它是目前危害人类健康最严重的疾病之一。现有的肿瘤治疗方法主要包括化疗与放射疗法，疗效不够理想，对人体机能损伤很大，因而研究更为简单有效的新型绿色疗法十分必要。利用磁场的生物效应来治疗肿瘤正是这些新疗法中一个可行的发展方向。磁场可分为稳恒磁场和可变磁场，稳恒和变化的属性除了与磁场源有关外，还和磁场与机体的相对运动密切相关。磁场的类型及其物理参数的差异会导致磁场所致生物效应之不同。变化磁场又因频率高低不同、作用时间长短不一也会产生不同的生物效应。近年来，国内外最新的研究成果表明，0-300Hz的低频电磁场可以有效抑制肿瘤增殖，诱导肿瘤细胞凋亡，不同类型的肿瘤的抑制效果主要与电磁场的参数(频率，强度，类型)有关，其中磁场频率是抑制肿瘤细胞增殖的最重要因素。文章“Cancer cellproliferation is inhibited by specific modulation frequencies”文中称，低频电磁场在治疗癌变肿瘤方面有着惊人的效果。研究发现，频率在0.1赫兹到114千赫的低频电磁场能够抑制部分患者体内恶性肿瘤的生长。据悉，不同癌症对应着不同的频率，这一研究成果或许能把癌症从不治之症的名单上抹掉。Tumor is a neoplasm that is formed by abnormal proliferation of cells in local tissues under the action of various tumorigenic factors. It is one of the most serious diseases that endanger human health. Existing tumor treatment methods mainly include chemotherapy and radiotherapy. The curative effect is not ideal and the human body function is greatly damaged. Therefore, it is necessary to study new simpler and more effective green treatments. Using the biological effects of magnetic fields to treat tumors is one possible development direction for these new therapies. The magnetic field can be divided into a steady magnetic field and a variable magnetic field. The properties of stability and change are not only related to the magnetic field source, but also closely related to the relative motion of the magnetic field and the body. Differences in the type of magnetic field and its physical parameters lead to differences in the biological effects of the magnetic field. The changing magnetic field will also produce different biological effects due to different frequencies and different durations of action. In recent years, the latest research results at home and abroad have shown that low-frequency electromagnetic fields of 0-300 Hz can effectively inhibit tumor proliferation and induce tumor cell apoptosis. The inhibition effect of different types of tumors is mainly related to the parameters (frequency, intensity, type) of electromagnetic fields. Among them, the frequency of magnetic field is the most important factor to inhibit the proliferation of tumor cells. The article "Cancer cellproliferation is inhibited by specific modulation frequencies" states that low-frequency electromagnetic fields have amazing effects in the treatment of cancerous tumors. The study found that low-frequency electromagnetic fields with frequencies ranging from 0.1 Hz to 114 kHz can inhibit the growth of malignant tumors in some patients. It is reported that different cancers correspond to different frequencies, and this research result may be able to erase cancer from the list of incurable diseases.
美国专利US8019414，US8406870公开了一种100-300kHz的中频磁场治疗仪，可应用于复发与初发的神经胶质母细胞瘤。美国专利US8192969公开了一个可产生1-1000Hz和1-100mT电磁场的装置可以干预细胞的存活。US Patents US8019414 and US8406870 disclose a 100-300kHz medium frequency magnetic field therapeutic apparatus, which can be applied to recurrent and primary glioblastoma. US Patent US8192969 discloses a device that can generate electromagnetic fields of 1-1000 Hz and 1-100 mT to interfere with cell survival.
CN1053555公开了“强磁场治癌装置”，提出一种用于治疗癌症的磁场强度高于0.4特斯拉(T)的磁疗式强磁场治癌装置。能产生强磁场的磁场装置包括恒定强磁场装置和脉冲强磁场装置。CN1053555 discloses a "strong magnetic field cancer treatment device", and proposes a magnetic therapy type strong magnetic field cancer treatment device with a magnetic field strength higher than 0.4 Tesla (T) for treating cancer. Magnetic field devices that can generate strong magnetic fields include constant strong magnetic field devices and pulsed strong magnetic field devices.
CN2721133Y公开了“脉冲电磁场肿瘤治疗装置”，提出了一种用于恶性肿瘤治疗的脉冲电磁场。CN2721133Y discloses a "pulse electromagnetic field tumor treatment device", which proposes a pulsed electromagnetic field for the treatment of malignant tumors.
CN207168835U公开了“具有肿瘤抑制作用的工频电磁场发生装置”，CN106621050A公开了“具有肿瘤抑制作用的工频电磁场发生装置和加载方式”，提出了一种抑制效应的电磁场，其加载方式具有一定拓展性，其频率在30-300Hz范围内，静态与交变磁场强度比值在0.5-2.5范围内，总强度在1-10mT范围内。其可作用于生物体，无创低毒副作用，对多种肿瘤具有显著的抑制作用，磁场作用可增加细胞内超氧自由基含量，并促进细胞自噬。CN207168835U discloses "power frequency electromagnetic field generating device with tumor suppressing effect", CN106621050A discloses "power frequency electromagnetic field generating device with tumor suppressing effect and loading method", and proposes an electromagnetic field with suppressing effect, and its loading method has a certain expansion The frequency is in the range of 30-300Hz, the ratio of static and alternating magnetic field strength is in the range of 0.5-2.5, and the total intensity is in the range of 1-10mT. It can act on living organisms, is non-invasive and has low toxicity and side effects, and has a significant inhibitory effect on various tumors. The effect of magnetic field can increase the content of superoxide free radicals in cells and promote autophagy.
以上技术都针对体内肿瘤治疗或体外肿瘤细胞实验提出了交变磁场或/与稳恒磁场治疗的装置，频率与场强范围可调，但运行时，仅能产生具有单一频率的磁场，而肿瘤的治疗有频率依赖性，不同肿瘤无法使用单一频率达到最佳治疗效果，为了提升磁场应用于不同肿瘤细胞治疗的普适性。The above technologies all propose devices for treatment of alternating magnetic fields or/and steady and constant magnetic fields for in vivo tumor treatment or in vitro tumor cell experiments. The frequency and field strength ranges are adjustable, but during operation, only a magnetic field with a single frequency can be generated. The treatment of magnetic field is frequency-dependent, and different tumors cannot use a single frequency to achieve the best therapeutic effect. In order to improve the universality of magnetic field in the treatment of different tumor cells.
发明内容SUMMARY OF THE INVENTION
本发明的目的针对上述现有技术的不足，提供一种用于肿瘤治疗的低频段宽频带磁场治疗仪。The object of the present invention is to provide a low-frequency broadband magnetic field therapeutic apparatus for tumor treatment in view of the above-mentioned deficiencies of the prior art.
本发明的另一目的就是提供一种用于肿瘤治疗的低频段宽频带磁场治疗仪的应用方法Another object of the present invention is to provide an application method of a low-frequency broadband magnetic field therapeutic apparatus for tumor treatment
本发明是这样实现的，The present invention is realized in this way,
一种用于肿瘤治疗的低频段宽频带磁场治疗仪，该治疗仪包括：上位机、主控单元、多通道宽频信号发生单元、信号调理单元、功率放大单元、亥姆霍兹线圈组、磁场测量单元、PID反馈调节单元以及温度反馈单元，其中A low-frequency broadband magnetic field therapeutic apparatus for tumor treatment, the therapeutic apparatus comprises: a host computer, a main control unit, a multi-channel broadband signal generating unit, a signal conditioning unit, a power amplifying unit, a Helmholtz coil group, a magnetic field Measurement unit, PID feedback adjustment unit and temperature feedback unit, wherein
所述上位机向主控单元传达指令；The upper computer transmits an instruction to the main control unit;
所述主控单元控制多通道宽频信号发生单元产生直流信号，经由信号调理单元以及功率放大单元处理后输出到亥姆霍兹线圈组中；The main control unit controls the multi-channel broadband signal generating unit to generate a DC signal, which is processed by the signal conditioning unit and the power amplifying unit and then output to the Helmholtz coil group;
所述亥姆霍兹线圈组产生磁场；the Helmholtz coil set generates a magnetic field;
所述磁场测量单元测量中心区域场强发送给PID反馈调节单元后经由PID反馈调节单元发送至主控单元，形成闭环反馈控制系统；The magnetic field measurement unit measures the field strength in the central area and sends it to the PID feedback adjustment unit and then sends it to the main control unit via the PID feedback adjustment unit to form a closed-loop feedback control system;
所述温度反馈单元测量测量亥姆霍兹线圈组各个角落的温度信息反馈给上位机使得温度稳定在人体接收的正常温度范围内。The temperature feedback unit measures and measures the temperature information of each corner of the Helmholtz coil group and feeds it back to the upper computer, so that the temperature is stable within the normal temperature range received by the human body.
进一步地，所述亥姆霍兹线圈组为半径相同，匝数相等的多对线圈组成的圆环，使用时人体位于圆环内，其中每对线圈同轴，且每对线圈之间的间距相等，每对线圈由同一根铜线绕制而成，匝数相同，多对线圈中心位于同一平面。Further, the Helmholtz coil group is a ring composed of multiple pairs of coils with the same radius and the same number of turns. The human body is located in the ring when in use, wherein each pair of coils is coaxial, and the distance between each pair of coils is Equal, each pair of coils is made of the same copper wire, the number of turns is the same, and the centers of multiple pairs of coils are located on the same plane.
进一步地，所述线圈为4对，经由其中的一对线圈经各线圈中心所在平面顺时针旋转45，90，135度分别可与其他的线圈重合。Further, there are 4 pairs of the coils, and one pair of coils can be rotated 45, 90, and 135 degrees clockwise through the plane where the center of each coil is located to overlap with other coils, respectively.
进一步地，多通道宽频信号发生单元产生对应多对线圈的多路电流值为的直流信号。Further, the multi-channel broadband signal generating unit generates DC signals corresponding to the multi-channel current values of the plurality of pairs of coils.
进一步地，所述上位机接收温度反馈单元测试的各个角落的温度信息反馈，若温度稳定在人体正常温度范围内，则安全性测试通过；若低于正常温度范围时，则上位机通过主控单元调节多通道宽频信号发生单元产生的电流大小，直至温度稳定在人体正常温度范围，进行安全测试，并提取此时多通道宽频信号发生单元输出的电流范围Id～Iu，记为“安全输入电流范围”。Further, the host computer receives the temperature information feedback of each corner of the temperature feedback unit test, if the temperature is stable within the normal temperature range of the human body, the safety test is passed; if it is lower than the normal temperature range, then the host computer passes the main control. The unit adjusts the magnitude of the current generated by the multi-channel broadband signal generating unit until the temperature is stable within the normal temperature range of the human body, conducts a safety test, and extracts the current range I d ~ I u output by the multi-channel broadband signal generating unit at this time. Input Current Range".
进一步地，所述上位机向主控单元传达稳定性测试指令，主控单元控制多通道宽频信号发生单元产生多路电流值为Iin的直流信号，上位机同时通过主控单元提取功率放大单元的输出电流Iout，并利用电流值Iout及亥姆霍兹线圈组模型进行物理场仿真，得到磁场中心均匀区域的磁场强度B0，并将场强值B0发送至PID反馈调节单元，作为预设磁场强度；磁场测量单元实时采集中心磁场的场强及方向信息，一路经主控单元将亥姆霍兹线圈组中心区域测得的磁场方向发送至上位机由上位机记录保存；另一路将中心区域场强发送给PID反馈调节单元，形成闭环反馈控制系统。Further, the host computer conveys the stability test instruction to the main control unit, and the main control unit controls the multi-channel broadband signal generating unit to generate a multi-channel current value of the direct current signal of I in , and the host computer extracts the power amplifying unit by the main control unit simultaneously. and use the current value I out and the Helmholtz coil group model to perform physical field simulation to obtain the magnetic field strength B 0 in the uniform area of the magnetic field center, and send the field strength value B 0 to the PID feedback adjustment unit, As the preset magnetic field strength; the magnetic field measurement unit collects the field strength and direction information of the central magnetic field in real time, and sends the magnetic field direction measured in the central area of the Helmholtz coil group to the upper computer through the main control unit for recording and saving; All the way, the field strength in the central area is sent to the PID feedback adjustment unit to form a closed-loop feedback control system.
一种用于肿瘤治疗的低频段宽频带磁场治疗仪的应用方法，包括：包括安全性测试、稳定性测试以及治疗阶段；An application method of a low-frequency broadband magnetic field therapeutic apparatus for tumor treatment, comprising: including a safety test, a stability test and a treatment stage;
其中，安全性测试，上位机向主控单元传达安全性测试指令，主控单元控制多通道宽频信号发生单元产生多路电流值为I0的直流信号，经信号调理单元、功率放大单元与亥姆霍兹线圈组相连，温度反馈单元经主控单元将分布在亥姆霍兹线圈组各个角落的温度信息反馈给上位机，若温度稳定在人体正常温度范围内，则安全性测试通过；若低于人体正常温度范围时，则上位机通过主控单元调节多通道宽频信号发生单元产生的电流大小，直至温度稳定在人体正常温度范围内，安全测试通过；上位机经主控单元提取此时多通道宽频信号发生单元输出的电流范围Id～Iu，记为“安全输入电流范围”，用于后续测试及治疗，若输入电流超出此范围内，则系统不工作；Among them, in the safety test, the host computer transmits the safety test command to the main control unit, and the main control unit controls the multi-channel broadband signal generation unit to generate a multi-channel DC signal with a current value of I 0 , which is passed through the signal conditioning unit, power amplifier unit and Hai The Helmholtz coil group is connected, and the temperature feedback unit feeds back the temperature information distributed in each corner of the Helmholtz coil group to the upper computer through the main control unit. If the temperature is stable within the normal temperature range of the human body, the safety test is passed; if When the temperature is lower than the normal temperature range of the human body, the host computer adjusts the current generated by the multi-channel broadband signal generating unit through the main control unit until the temperature is stable within the normal temperature range of the human body, and the safety test passes; The current range I d ~ I u output by the multi-channel broadband signal generating unit is marked as "safe input current range", which is used for subsequent testing and treatment. If the input current exceeds this range, the system will not work;
稳定性测试：安全输入电流范围，选取一电流值Iin作为输入电流，上位机向主控单元传达稳定性测试指令，上位机同时通过主控单元提取功率放大单元的输出电流Iout，并利用电流值Iout及亥姆霍兹线圈组模型进行物理场仿真，得到磁场中心均匀区域的磁场强度B0，并将场强值B0发送至PID反馈调节单元，作为预设磁场强度，磁场测量单元实时采集中心磁场的场强及方向信息，一路经主控单元将亥姆霍兹线圈组中心区域测得的磁场方向发送至上位机由上位机记录保存；另一路将中心区域场强发送给PID反馈调节单元，形成闭环反馈控制系统，其中PID反馈调节单元负责降低当前测得的磁场强度与预设磁场强度B0之间的稳态误差，直至误差小于设定值，PID反馈调节单元停止工作，上位机记录此时多通道宽频信号发生单元输出的电流值Iw，记做“工作电流”，稳定性测试通过；Stability test: safe input current range, select a current value I in as the input current, the host computer transmits the stability test command to the main control unit, and the host computer simultaneously extracts the output current I out of the power amplifier unit through the main control unit, and uses The current value I out and the Helmholtz coil group model are used for physical field simulation to obtain the magnetic field strength B 0 in the uniform area in the center of the magnetic field, and the field strength value B 0 is sent to the PID feedback adjustment unit as the preset magnetic field strength. The unit collects the field strength and direction information of the central magnetic field in real time, and sends the magnetic field direction measured in the central area of the Helmholtz coil group to the upper computer through the main control unit for recording and saving; The PID feedback adjustment unit forms a closed-loop feedback control system, in which the PID feedback adjustment unit is responsible for reducing the steady-state error between the currently measured magnetic field strength and the preset magnetic field strength B0 , until the error is less than the set value, the PID feedback adjustment unit stops Work, the host computer records the current value Iw output by the multi-channel broadband signal generating unit at this time, and records it as "working current", and the stability test is passed;
治疗阶段：上位机经主控单元向多通道宽频信号发生单元传达发射指令，多通道宽频信号发生单元产生强度等于“工作电流”的白噪声信号，经信号调理单元处理后，经功率放大单元将信号分别输入亥姆霍兹线圈对，在中心区域产生一定空间均匀的磁场，对病人患处的肿瘤进行非侵入式治疗。Treatment stage: the host computer transmits the transmission command to the multi-channel broadband signal generating unit through the main control unit, and the multi-channel broadband signal generating unit generates a white noise signal with an intensity equal to the "working current". The signals are respectively input to the pair of Helmholtz coils, and a certain spatially uniform magnetic field is generated in the central area to perform non-invasive treatment on the tumor of the patient's affected area.
进一步地，安全性测试中若低于人体正常温度范围，则将多通道宽频信号发生单元产生的电流调节为I0+5mA；高于人体正常温度范围时，则减小多通道宽频信号发生单元产生的电流至I0-5mA。Further, in the safety test, if it is lower than the normal temperature range of the human body, the current generated by the multi-channel broadband signal generation unit is adjusted to I 0 +5mA; when it is higher than the normal temperature range of the human body, the multi-channel broadband signal generation unit is reduced. The resulting current is I 0 -5mA.
进一步地，PID反馈调节单元具体调节方式表现为：若当前磁场强度大于预设磁场强度，则将输入电流Iin调低，反之，则增加当前的输入电流信号Iin调高。Further, the specific adjustment method of the PID feedback adjustment unit is as follows: if the current magnetic field strength is greater than the preset magnetic field strength, the input current I in is adjusted lower; otherwise, the current input current signal I in is increased and raised.
进一步地，治疗阶段中照射磁场的强度与输入电流有关，需要增大磁场强度时，需要在“安全输入电流范围”内，提高输入电流值，并重新进行稳定性测试。Further, the intensity of the irradiated magnetic field in the treatment stage is related to the input current. When the intensity of the magnetic field needs to be increased, the input current value needs to be increased within the "safe input current range", and the stability test must be performed again.
本发明与现有技术相比，有益效果在于：本发明覆盖了具有肿瘤抑制作用的电磁场频率段，磁场治疗仪实现了0.1Hz-300Hz频率范围内随机频率的磁场的产生，将数个有效抑瘤频率整合到一起，安全稳定，操作便捷，磁场方向及大小可控，应用时无需事先对不同肿瘤的最佳磁场抑制频率进行研究，既节约时间，避免了由于磁场频率特异性引起的疗效不佳，又提高了效率，增加了磁场疗法应用于不同肿瘤的普适性，可对多种肿瘤有显著的抑制作用。Compared with the prior art, the present invention has the beneficial effects that: the present invention covers the frequency range of the electromagnetic field with tumor suppressing effect, and the magnetic field therapy device realizes the generation of a magnetic field with a random frequency in the frequency range of 0.1Hz-300Hz, and effectively suppresses several The tumor frequency is integrated together, which is safe and stable, easy to operate, and the direction and size of the magnetic field are controllable. There is no need to study the optimal magnetic field suppression frequency for different tumors in advance, which not only saves time, but also avoids the effect of different therapeutic effects caused by the specificity of the magnetic field frequency. It also improves the efficiency, increases the universality of the magnetic field therapy applied to different tumors, and can have a significant inhibitory effect on a variety of tumors.
附图说明Description of drawings
图1本发明用于肿瘤治疗的低频段宽频带磁场治疗仪系统框图；Fig. 1 is a system block diagram of a low-frequency broadband magnetic field therapeutic apparatus for tumor treatment according to the present invention;
图2本发明低频段宽频带磁场治疗仪应用中的示意图；2 is a schematic diagram of the application of the low-frequency broadband magnetic field therapeutic apparatus of the present invention;
图3本发明亥姆霍兹线圈组分布示意图；3 is a schematic diagram of the distribution of the Helmholtz coil group of the present invention;
图4本发明物理场仿真示意图。FIG. 4 is a schematic diagram of the physical field simulation of the present invention.
具体实施方式Detailed ways
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention, but not to limit the present invention.
参见图1see Figure 1
本发明涉及一种用于肿瘤治疗的低频段宽频带磁场治疗仪，是由上位机1经主控单元2、多通道宽频信号发生单元3、信号调理单元4、功率放大单元5与亥姆霍兹线圈组6连接，主控单元2分别与信号调理单元4及功率放大单元5连接，温度反馈单元8与上位机1相连，磁场测量单元7经PID反馈调节单元9与主控单元2连接组成。The invention relates to a low-frequency broadband magnetic field therapy instrument for tumor treatment, which is composed of a
所述上位机向主控单元传达指令；所述主控单元控制多通道宽频信号发生单元产生直流信号，经由信号调理单元以及功率放大单元处理后输出到亥姆霍兹线圈组中；所述亥姆霍兹线圈组产生磁场；所述磁场测量单元测量中心区域场强发送给PID反馈调节单元后经由PID反馈调节单元发送至主控单元，形成闭环反馈控制系统；The host computer transmits instructions to the main control unit; the main control unit controls the multi-channel broadband signal generating unit to generate a DC signal, which is processed by the signal conditioning unit and the power amplifying unit and then output to the Helmholtz coil group; The Mholtz coil group generates a magnetic field; the magnetic field measurement unit measures the field strength in the central area and sends it to the PID feedback adjustment unit and then sends it to the main control unit via the PID feedback adjustment unit to form a closed-loop feedback control system;
所述温度反馈单元测量测量亥姆霍兹线圈组各个角落的温度信息反馈给上位机使得温度稳定在人体接收的正常温度范围内。The temperature feedback unit measures and measures the temperature information of each corner of the Helmholtz coil group and feeds it back to the upper computer, so that the temperature is stable within the normal temperature range received by the human body.
本实施例中，所述亥姆霍兹线圈组6为半径相同，匝数相等的四对线圈组成，包括第一对亥姆霍兹线圈，第二对亥姆霍兹线圈，第三对亥姆霍兹线圈及第四对亥姆霍兹线圈，分布如图3所示，其中每对线圈同轴，且间距相等，由同一根铜线绕制而成，匝数相同，四对线圈中心皆位于同一平面，第一对亥姆霍兹线圈经各线圈中心所在平面顺时针旋转45，90，135度分别可与第二对亥姆霍兹线圈，第二对亥姆霍兹线圈，第三对亥姆霍兹线圈重合。In this embodiment, the Helmholtz coil group 6 is composed of four pairs of coils with the same radius and the same number of turns, including a first pair of Helmholtz coils, a second pair of Helmholtz coils, and a third pair of Helmholtz coils. The distribution of Helmholtz coils and the fourth pair of Helmholtz coils is shown in Figure 3. Each pair of coils is coaxial and has the same spacing. It is wound from the same copper wire with the same number of turns. They are all located in the same plane. The first pair of Helmholtz coils can be rotated 45, 90, and 135 degrees clockwise through the plane where the center of each coil is located. Three pairs of Helmholtz coils coincide.
参见图2所示，所述亥姆霍兹线圈组6被安装在可调支架10上，可根据患者患癌部位进行水平与垂直位置的调整。Referring to Fig. 2, the Helmholtz coil set 6 is mounted on an
本发明提供一种用于肿瘤治疗的低频段宽频带磁场治疗仪的应用方法，按以下步骤工作：包括安全性测试、稳定性测试以及治疗阶段。The invention provides an application method of a low-frequency broadband magnetic field therapeutic apparatus for tumor treatment, which works according to the following steps: including safety testing, stability testing and treatment stages.
a、安全性测试：a. Security test:
上位机1向主控单元2传达安全性测试指令，主控单元2控制多通道宽频信号发生单元3产生四路电流值为I0的直流信号，经信号调理单元4、功率放大单元5与亥姆霍兹线圈组6相连，温度反馈单元8经主控单元2将分布在亥姆霍兹线圈组6各个角落的温度信息反馈给上位机1，实时监测6小时，若温度稳定在人体正常温度范围36-37摄氏度内，则安全性测试通过；若低于36摄氏度或高于37摄氏度时，则上位机1通过主控单元2调节多通道宽频信号发生单元3产生的电流大小，直至温度稳定在36至37摄氏度范围内，安全测试通过。上位机1经主控单元2提取此时多通道宽频信号发生单元3输出的电流范围Id～Iu，记为“安全输入电流范围”，用于后续测试及治疗，若输入电流超出此范围内，则系统不工作。The
具体调节方式为：若低于36摄氏度，则将多通道宽频信号发生单元3产生的电流调节为I0+5mA；高于37摄氏度时，则减小多通道宽频信号发生单元3产生的电流至I0-5mA。The specific adjustment method is as follows: if the temperature is lower than 36 degrees Celsius, the current generated by the multi-channel broadband signal generating unit 3 is adjusted to I 0 +5mA; when it is higher than 37 degrees Celsius, the current generated by the multi-channel broadband signal generating unit 3 is reduced to I 0 -5mA.
b、稳定性测试：在Id至Iu之间，选取一电流值Iin作为输入电流，上位机1向主控单元2传达稳定性测试指令，主控单元2控制多通道宽频信号发生单元3产生四路电流值为Iin的直流信号，经信号调理单元4、功率放大单元5后输入到亥姆霍兹线圈组6中。上位机1同时通过主控单元2提取功率放大单元5的输出电流Iout，并利用电流值Iout及亥姆霍兹线圈组模型进行物理场仿真(参见图3所示)，得到磁场中心均匀区域的磁场强度B0，并将场强值B0发送至PID反馈调节单元9，作为预设磁场强度。磁场测量单元7实时采集中心磁场的场强及方向信息，一路经主控单元2将亥姆霍兹线圈组6中心区域测得的磁场方向发送至上位机1由上位机记录保存；另一路将中心区域场强发送给PID反馈调节单元9，形成闭环反馈控制系统，其中PID反馈调节单元9负责降低当前测得的磁场强度与预设磁场强度B0之间的稳态误差，直至误差小于1％，PID反馈调节单元9停止工作，上位机1记录此时多通道宽频信号发生单元3输出的电流值Iw，记做“工作电流”，稳定性测试通过。b, stability test: between I d to I u , select a current value I in as the input current, the
PID反馈调节单元9具体调节方式表现为：若当前磁场强度大于预设磁场强度，则将输入电流Iin调低，反之，则增加当前的输入电流信号Iin调高。The specific adjustment method of the PID feedback adjustment unit 9 is as follows: if the current magnetic field strength is greater than the preset magnetic field strength, the input current I in is adjusted lower; otherwise, the current input current signal I in is increased and raised.
c、治疗阶段：c. Treatment stage:
(1)首先，根据病人患瘤部位的信息，调节可调支架10上的亥姆霍(1) First, adjust the Helmhol on the
兹线圈组6的垂直位置，使亥姆霍兹线圈组6中各线圈圆心与病人患癌部位在同一平面内，然后调整亥姆霍兹线圈组6的水平位置，使患者患癌部位位于线圈组6的中心处；Adjust the vertical position of the coil group 6 so that the center of each coil in the Helmholtz coil group 6 is in the same plane as the patient's cancer site, and then adjust the horizontal position of the Helmholtz coil group 6 so that the patient's cancer site is located in the coil at the center of group 6;
(2)上位机1经主控单元2向多通道宽频信号发生单元3传达发射指令，多通道宽频信号发生单元3产生四路强度等于“工作电流”的白噪声信号，即功率谱密度在整个频域内分布均匀，且强度恒定为Iw的信号，经信号调理单元4处理后，滤除了频率大于300Hz以及小于0.1Hz的信号，输出四路0.1Hz-300Hz宽带低频信号，经功率放大单元5将四路信号分别输入亥姆霍兹线圈对1，亥姆霍兹线圈对2，亥姆霍兹线圈对3及亥姆霍兹线圈对4，亥姆霍兹线圈组5中心区域产生一定空间均匀的磁场，对病人患处的肿瘤进行非侵入式治疗，可根据病情差异，条件照射时长及照射磁场强度。需要注意的是，照射磁场的强度与输入电流有关，需要增大磁场强度时，需要在“安全输入电流范围”内，提高输入电流值，并重新进行稳定性测试后，才能用于治疗。(2) The
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等，均应包含在本发明的保护范围之内。The above descriptions are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements and improvements made within the spirit and principles of the present invention shall be included in the protection of the present invention. within the range.
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