CN109876107A - A kind of antipruritic Chinese medicine composition of natural antibacterial and application thereof - Google Patents
A kind of antipruritic Chinese medicine composition of natural antibacterial and application thereof Download PDFInfo
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Abstract
A kind of antipruritic Chinese medicine composition of natural antibacterial, which is characterized in that combined by Chinese medicine composition I and Chinese medicine composition II.The Chinese medicine composition I is made of kuh-seng, the tuber of stemona, Chinese prickly ash, cortex dictamni, borax；The Chinese medicine composition II is made of marrow spinulose tree fern, pine needle, peppermint；The marrow spinulose tree fern is white spinulose tree fern also known as tree fern, fern tree, and spinulose tree fern and Chinese medicine keel wind, some areas are also known as stem of Spinulose Tree Fem, big rhizome of cyrtomium.The antipruritic Chinese medicinal lotion of natural antibacterial that Chinese medicine composition I extracting solution and Chinese medicine composition II are mixed with.The antipruritic Chinese medicinal lotion of natural antibacterial is as anti-dandruff and itching-relieving agent in hair washing product.
Description
Technical field
The invention belongs to the field of Chinese medicines and daily cosmetics technical fields, and in particular to a kind of antipruritic Chinese medicine group of natural antibacterial
Close object and application thereof.
Background technique
Dandruff is a kind of chronic, easy to recur, more typical scalp problems, compares normal scalp, on scalp or in hair
Laminar scurf occur is dandruff.Under normal circumstances, desquamation and cytothesis are in dynamic equilibrium, completely
The keratinocyte aggregation composition diameter of angling maturation is less than the sightless agglomerate of 0.2mm naked eyes and falls off, and macroscopic angling is thin
Born of the same parents' agglomerate is then considered as dandruff, and pathologic finding shows as keratinocyte parakeratosis, undue growth, malalignment etc., squama
Remaining nucleus can be observed in bits under the microscope.In addition to sheet furfur, the main clinical manifestation of dandruff is itch, scalp
Dry tight feeling is strong, and shouting pain, there are Sub-clinical inflammation changes.There are about 50% or more crowds to be asked by dandruff in the whole world at present
The puzzlement of topic, young artificial multiple crowd and illness is more serious, usual male's disease incidence is higher than women.
With the improvement of living standards, environmental pollution is increasingly severe, in addition job and life stress is excessive, irregular life
The problem of causing various intractable dandruffs and head to be itched appearance.
Chlosma (Malassezia) is focused primarily upon for the research of dandruff mechanism and means of prevention at present
Aspect, and dandruff influence factor is numerous, pathogenesis is complicated, is related to scalp lipid, scalp Tiny ecosystem, scalp physiology, is immunized
Anti-oxidant equal many factors.
The excessive crowd of dandruff is accustomed to relying on dandruff control shampoo containing removal dandruff.And current most of common dandruff control shampoo containing articles
In the anti-dandruff agent used be mostly antimycotic chemotherapeutic agent, such as zinc pyrithione, sulfide, climbazole, ketoconazole.Though
Right this kind of anti-dandruff agent can remove dandruff, but be used for a long time and can generate injury to scalp, and there are clinical treatments to be not thorough, and the state of an illness is anti-
Recurrence is made, and scalp cannot be not only nourished, and can decompose peeling those dryings, loose skin instead, be the case where dandruff falls off
Aggravation.
There is the people of dandruff, with this scalp hair follicles inflammation, red pimple, scalp moss phenomenon.In this case, common hair washing
Water cannot make its elimination, as hair follicle inflammation, red pimple are all that the grease glandular secretion that hair is distributed crosses many greases of sauce and blocks hair
Hole breeds bacterium in the hair follicle of scalp.
The Chinese patent drug skin disease lotion ratified through state food pharmaceuticals administration, by kuh-seng, the tuber of stemona, Chinese prickly ash, cortex dictamni, boron
Sand, realgar composition.With removing toxic substances desinsection, antipruritic convergence, the effect of promoting blood circulation.For scabies, eczema, seborrhea, scabies
Itching property skin, tinea versicolor.
Its prescription are as follows: kuh-seng 250g, tuber of stemona 250g, Chinese prickly ash 250g, cortex dictamni 250g, borax 167g, realgar 83g.
Its preparation method are as follows: the above Six-element, kuh-seng, the tuber of stemona, Chinese prickly ash, cortex dictamni decoct twice water, 2 hours every time, filter, close
And filtrate, it is concentrated into right amount, borax is added, is stirred to dissolve, 1000ml is made, medical fluid dispenses while stirring；Realgar is ground into
Fine powder, is made particle, be separately distributed into pouch to get.
Usage and dosage: external application is cleaned affected part with warm water, and appended pouch realgar particle is added into the liquid shake using preceding
It is even, part medical fluid is taken out, is diluted in the ratio of 1:150 with warm water, puts or wash affected part on the skin outside, each 1 time sooner or later, dosage can be by affected part
Depending on size, or follow the doctor's advice.
Making and using for skin disease lotion has the disadvantage that realgar is unstable in the solution, needs to face and be matched with facing, is grasped
It makes comparisons trouble, it is improper to store, and the validity of realgar can also reduce.Realgar is the 28 Poisoning medicinal materials that the Ministry of Public Health promulgates in prescription
One of, it even if flying to dry using powder-refining with water shampoo, but still not can be removed toxicity, bring dangerous hidden danger, realgar to the use of patient
The report of external application poisoning is relatively more.Realgar is cosmetics banned substance.
In practice process, discovery skin disease lotion plays the role of inhibition to scalp inflammation and dandruff production for we.We are logical
It crosses experimental verification skin disease lotion restraining and sterilizing bacteria ability and finds out seborrhea of the concentration for scalp of best skin disease lotion
With anti-dandruff effect.Using the minimum inhibitory concentration of skin disease lotion as index, it is mixed that independent realgar with equivalent purified water dissolves to obtain realgar
Suspension shakes up before use.
Medical fluid restraining and sterilizing bacteria experimental result table
| Medical fluid | Staphylococcus aureus | Pityrosporon ovale | Anti-dandruff effect * |
| Skin disease lotion | - | - | 4/5 |
| Skin disease lotion-realgar | - | + | 2/5 |
| Realgar | - | - | 3/5 |
Note :+developmental tube has bacterium growth；Developmental tube sterile production；Anti-dandruff effect is tested with 5 people
Experiments have shown that skin disease lotion has stronger bacteriostasis to pityrosporum furfur, the skin disease lotion of realgar is not added to chaff spore
The bacteriostasis of bacterium is not so good as skin disease lotion and independent realgar suspension.
Summary of the invention
The technical problem to be solved in the present invention is that find substitution realgar, provide it is a kind of it is highly-safe, stability is good, effect
The antipruritic pharmaceutical composition and preparation method thereof of significant new compound antibacterial.
It is a further object of the present invention to provide the purposes of the antipruritic Chinese traditional medicine composition of above-mentioned compound antibacterial.
A kind of antipruritic Chinese medicine composition of natural antibacterial, which is characterized in that by Chinese medicine composition I and II group of Chinese medicine composition
It closes.
The Chinese medicine composition I is made of kuh-seng, the tuber of stemona, Chinese prickly ash, cortex dictamni, borax；The Chinese medicine composition II
It is made of marrow spinulose tree fern, pine needle, peppermint.
The marrow spinulose tree fern, for white spinulose tree fern also known as tree fern, fern tree, spinulose tree fern and Chinese medicine keel wind, some areas are also known as
For stem of Spinulose Tree Fem, big rhizome of cyrtomium.
The Chinese medicine composition I by Chinese traditional medicine composition according to the mass fraction by being formed below: 50 parts of kuh-seng, the tuber of stemona 50
Part, 50 parts of Chinese prickly ash, 50 parts of shaggy-fruited dittany root skin, 33 parts of borax；
The Chinese medicine composition II is formed by following Chinese traditional medicine composition according to the mass fraction: 20-100 parts of marrow spinulose tree fern, pine needle 20-
100 parts, 20-100 parts of peppermint.
The Chinese medicine composition II, it is characterised in that preferred scope is 40-70 parts of marrow spinulose tree fern, 30-60 parts of pine needle, peppermint
40-70 parts.
Each Chinese medicine medicinal function of the present invention is:
Marrow spinulose tree fern: also known as tree fern, fern tree, white spinulose tree fern, Cyatheaceae plant, it is the rare tree carried in the period Cretaceous period, is
Existing unique woody pteridophyte, it is extremely precious, it can be rated as national treasure.China is also known as big rhizome of cyrtomium, and stem has the title of keel wind,
Belong to strong medicine, there is dispelling wind and eliminating dampness, promoting blood circulation and removing obstruction in channels, relieving cough and asthma, clearing heat and detoxicating, desinsection and other effects.Vitexin is spinulose tree fern stem
The middle highest flavone compound of content, Vitexin have obviously Escherichia coli, staphylococcus aureus, bacillus subtilis
Inhibiting effect.
Marrow spinulose tree fern extract (1:20): marrow spinulose tree fern leaf/stem 1kg is extracted 3 times with 95% alcohol reflux, 3 hours every time, is concentrated
After obtain medicinal extract 50g, it is spare.
Pine needle is Siberian cedar, black pine, Chinese pine, Korean pine, Huashan pine, pinus yunnanensis, Simao in Pinaceae pine genus plant
The needle of pine, masson pine etc..Pine needle contains many active constituents, also applies in fields such as food, health care products relatively wide.Pine needle tea,
Extract from pine needles soft capsule, pine needle fat capsule etc..But wherein pine needle procyanidine is used to treat the research of alopecia seborrheica, day
It is more using pine needle in hair growth that this Kamimura A has been more research , Huen state dimension professor, but also and sees there is correlation
Reported literature.Deodar essential oil can be convergence, antibacterial characteristic most beneficial for oily skin, can effectively antagonize seborrhea, the head of scalp
Scurf and alopecia.
Pine needle spinulose tree fern extract (1:20): pine needle/bark 1kg, with 45% alcohol reflux extract 3 times, 3 hours every time, after concentration
Medicinal extract 50g is obtained, it is extract from pine needles (1:20) that medicinal extract, which is made, spare；
Peppermint oil is obtained by supercritical carbon dioxide extracting or steam distillation, and wherein menthol is greater than 60%.It is thin
Lotus essential oil is wider for antibacterial anti-inflammatory application, and it is the medicine of herbal that the main component of cooling ointment, which is exactly peppermint oil, menthol,
One of object has anti-inflammatory analgetic, while refrigerant feeling.
Kuh-seng: heat-clearing and damp-drying drug, desinsection, the function of diuresis.For hot dysentery, hematochezia, jaundice urodialysis, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae,
Eczema, wet sore, pruitus, castor control trichomonas vaginitis outside.
The tuber of stemona: moistening lung to lower qi cough-relieving, desinsection.It is used for head louse outside, body louse, enterobiasis, private parts, which is disturbed, to itch.
Chinese prickly ash: warming spleen and stomach for dispelling cold dehumidifies, analgesic, desinsection, solution fish raw meat poison.11 kinds of dermatophytes of volatile oil and 4 kinds of deep fungals
There are certain inhibition and killing effect.
Cortex dictamni: heat-clearing and damp-drying drug;Dispelling wind and arresting itching;Removing toxic substances.Rubeola caused by wind-heat wet poison;Eczema;Scabies;Jaundice;It is damp and hot
Numbness.
Borax: it can be used as detergent, cosmetics, insecticide.Borax has bactericidal effect, and borax still has anti-corrosion and protection skin
The effect of mucous membrane.Clinic can rinse ulcer, abscess, especially mucous membrane inflammation, such as conjunctivitis, gastritis with this product, because it is
Alkalinity can make mucous membrane de-sludging.
The preparation method of the antipruritic Chinese medicine composition of a kind of natural antibacterial, it is characterised in that include the following steps:
(1) by Chinese medicine composition I: 50 mass parts of kuh-seng, 50 mass parts of the tuber of stemona, 50 mass parts of Chinese prickly ash, 50 mass of shaggy-fruited dittany root skin
Part mixing, adds 3 ~ 5 times of mass parts water, decocting/high-pressure extracting tank refluxing extraction twice, 2 hours every time, obtains decocting liquid；
(2) merging filtrate removes impurity, is concentrated into appropriate；
(3) 33 mass parts boraxs are added, stirring is completely dissolved, and suitable Chinese medicine composition I extracting solution is made.
(4) by marrow spinulose tree fern described in Chinese medicine composition II the preparation method comprises the following steps: marrow spinulose tree fern leaf/stem 1kg, with 95% ethyl alcohol
Refluxing extraction 3 times, 3 hours every time, medicinal extract 50g is obtained after concentration, it is marrow spinulose tree fern extract (1:20) that medicinal extract, which is made, spare；
By pine needle described in Chinese medicine composition II the preparation method comprises the following steps: pine needle/bark 1kg, extracted 3 times with 45% alcohol reflux,
3 hours every time, medicinal extract 50g is obtained after concentration, it is extract from pine needles (1:20) that medicinal extract, which is made, spare；
By peppermint described in Chinese medicine composition II the preparation method comprises the following steps: peppermint 2kg, be by supercritical carbon dioxide extracting or
Steam distillation obtains, and peppermint oil is made, wherein menthol is greater than 60%.
(5) by the Chinese medicine composition II: marrow spinulose tree fern extract (being equivalent to 20-100 parts of marrow spinulose tree fern), extract from pine needles
(being equivalent to pine needle 20-100 mass parts), peppermint oil (being equivalent to peppermint 20-100 mass) are added to drug composition I extracting solution, stir
Dissolution is mixed, 200 mass parts are concentrated into, the antipruritic Chinese medicinal lotion of natural antibacterial is made.
Effective effect of the embodiment of the present invention is: the anti-dandruff Chinese medicinal lotion of natural antibacterial of the invention, excessive to dandruff is caused
Fungi there is good inhibiting effect, while having the function of activating blood and clearing heat, dispelling wind and arresting itching.
Specific embodiment
The present invention will be further described for specific embodiment below, but not as a limitation of the invention.
Embodiment: the preparation of the anti-dandruff washing lotion of compound natural Chinese medicine antibacterial
The parts by weight of each Chinese medicine:
| Title | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Kuh-seng | 50 | 50 | 50 | 50 | 50 |
| The tuber of stemona | 50 | 50 | 50 | 50 | 50 |
| Chinese prickly ash | 50 | 50 | 50 | 50 | 50 |
| Cortex dictamni | 50 | 50 | 50 | 50 | 50 |
| Borax | 33 | 33 | 33 | 33 | 33 |
| Marrow spinulose tree fern | 60 | 20 | 100 | 100 | 50 |
| Pine needle | 45 | 100 | 20 | 100 | 50 |
| Peppermint | 60 | 100 | 100 | 20 | 50 |
Medical fluid minimum inhibitory concentration (MIC) observation experiment result table
| Medical fluid | Staphylococcus aureus | Pityrosporon ovale |
| Embodiment 1 | 1.56%(ml/ml) | 3.12%(ml/ml) |
| Embodiment 2 | 1.56%(ml/ml) | 12.5%(ml/ml) |
| Embodiment 3 | 1.56%(ml/ml) | 6.25%(ml/ml) |
| Embodiment 4 | 1.56%(ml/ml) | 3.12%(ml/ml) |
| Embodiment 5 | 1.56%(ml/ml) | 6.25%(ml/ml) |
| Skin disease lotion | 1.56%(ml/ml) | 6.25%(ml/ml) |
| Blank | + | + |
Note :+developmental tube has bacterium growth；Developmental tube sterile production；
The preferred scope of Chinese medicine composition II are as follows: 40 ~ 100 mass parts marrow spinulose tree ferns, 40 ~ 100 mass parts pine needles, 40 ~ 80 mass parts
Peppermint.
The anti-dandruff Chinese medicinal lotion of the natural antibacterial prepared in the embodiment of the present invention, may be added to that shampoo, hair conditioner, hair film,
The Shampoo & Conditioners kind such as gel, the additive amount of the anti-dandruff Chinese medicinal lotion of compound natural antibacterial are Shampoo & Conditioner weight 0.1 ~ 25%, this
The hair products of washing of invention preparation have many advantages, such as that safety, effect are good, non-stimulated.
Embodiment 6
The antipruritic Chinese medicinal lotion of natural antibacterial obtained by embodiment 1 and embodiment 4 is applied and washes shield product with anti-dandruff and itching-relieving.
Cocoamidopropyl betaine6%
Sodium lauroyl sarcosine 4.5%
Plantacare 818 4.5%
Conditioner 10%
Preservative 0.3%
Citric acid PH5.5 ~ 7.5
The antipruritic Chinese medicinal lotion 0.1% ~ 25% of natural antibacterial
Water complements to 100%
| Experiment 1 | Experiment 2 | Experiment 3 | Experiment 4 | |
| The antipruritic Chinese medicinal lotion of 1 natural antibacterial of embodiment | 0.1% | 5% | 10% | 25% |
| The antipruritic Chinese medicinal lotion of 4 natural antibacterial of embodiment | 0.1% | 5% | 10% | 25% |
The shampoo number serial number being prepared, uses object: has dandruff, hair greasy and scalp has inflammation (small red pimple),
First 3 days primary to wash daily, uses the next day rear, observing time is 2 weeks.
Add that 0.1% pair of hair cream is greasy and hair inflammation has slight improvement, 5% or more addition has and clearly inhibits head
Bits generate, and improve greasy and anti-inflammatory effect.
Inhibit the growth of fungi and bacterium according to the antipruritic Chinese medicinal lotion of natural antibacterial obtained, while reducing sebum secretion,
Inhibit the growth of fungi and bacterium according to the antipruritic Chinese medicinal lotion of natural antibacterial obtained, while reducing sebum secretion, acts on
In scalp hair follicles depths, diminishes inflammation, balances scalp bacterium colony, play the role of anti-dandruff and itching-relieving.
The present invention has supplied a kind of antipruritic Chinese medicine group of natural safe, mild natural antibacterial non-stimulated, that anti-dandruff anti-inflammatory effects are good
It closes object and its is washed in hair products for anti-dandruff and itching-relieving.
Embodiment described above, only one kind of the present invention more preferably specific embodiment, those skilled in the art
The usual variations and alternatives that member carries out within the scope of technical solution of the present invention should all be included in protection scope of the present invention.
Claims (8)
1. a kind of antipruritic Chinese medicine composition of natural antibacterial, which is characterized in that combined by Chinese medicine composition I and Chinese medicine composition II;
The Chinese medicine composition I is made of kuh-seng, the tuber of stemona, Chinese prickly ash, cortex dictamni, borax；The Chinese medicine composition II by marrow spinulose tree fern,
Pine needle, peppermint composition；
The marrow spinulose tree fern, is white spinulose tree fern also known as tree fern, fern tree, and spinulose tree fern and Chinese medicine keel wind, some areas also known as fly
Its Qin Liao, big rhizome of cyrtomium.
2. Chinese medicine composition I according to claim 1 by Chinese traditional medicine composition according to the mass fraction by being formed below: kuh-seng
50 parts, 50 parts of the tuber of stemona, 50 parts of Chinese prickly ash, 50 parts of shaggy-fruited dittany root skin, 33 parts of borax；
The Chinese medicine composition II is formed by following Chinese traditional medicine composition according to the mass fraction: 20-100 parts of marrow spinulose tree fern, pine needle 20-
100 parts, 20-100 parts of peppermint.
3. Chinese medicine composition II according to claim 2, it is characterised in that preferred scope is 40-70 parts of marrow spinulose tree fern, pine needle
30-60 parts, 40-70 parts of peppermint.
4. a kind of according to claim 1, preparation method of the antipruritic Chinese medicine composition of natural antibacterial described in 2,3, it is characterised in that
Include the following steps:
(1) by Chinese medicine composition I: 50 mass parts of kuh-seng, 50 mass parts of the tuber of stemona, 50 mass parts of Chinese prickly ash, 50 mass of shaggy-fruited dittany root skin
Part mixing, adds 3 ~ 5 times of mass parts water, decocting/high-pressure extracting tank refluxing extraction twice, 2 hours every time, obtains decocting liquid；
(2) merging filtrate removes impurity, is concentrated into appropriate；
(3) 33 mass parts boraxs are added, stirring is completely dissolved, and suitable Chinese medicine composition I extracting solution is made；
(4) by marrow spinulose tree fern described in Chinese medicine composition II the preparation method comprises the following steps: marrow spinulose tree fern leaf/stem 1kg, with 95% alcohol reflux
It extracts 3 times, 3 hours every time, medicinal extract 50g is obtained after concentration, it is marrow spinulose tree fern extract (1:20) that medicinal extract, which is made, spare；
By pine needle described in Chinese medicine composition II the preparation method comprises the following steps: pine needle/bark 1kg, extracted 3 times with 45% alcohol reflux,
3 hours every time, medicinal extract 50g is obtained after concentration, it is extract from pine needles (1:20) that medicinal extract, which is made, spare；
By peppermint described in Chinese medicine composition II the preparation method comprises the following steps: peppermint 2kg, be by supercritical carbon dioxide extracting or
Steam distillation obtains, and peppermint oil is made, wherein menthol is greater than 60%；
(5) by the Chinese medicine composition II: marrow spinulose tree fern extract (being equivalent to 20-100 parts of marrow spinulose tree fern), extract from pine needles (phase
When in pine needle 20-100 mass parts), peppermint oil (being equivalent to peppermint 20-100 mass) be added to drug composition I extracting solution, stir
Dissolution, is concentrated into 200 mass parts, and the antipruritic Chinese medicinal lotion of natural antibacterial is made.
5. the application of the antipruritic Chinese medicine composition of the described in any item natural antibacterials of claim 1 ~ 4, it is characterised in that: the day
Right anti-bacterial, anti-itching Chinese medicinal lotion is used to prepare anti-dandruff and itching-relieving and washes hair products；It is described wash hair products can for shampoo, hair conditioner,
Any one of hair film, hair gel, elastin.
6. composition according to claim 5 is in the application for preparing anti-dandruff and itching-relieving agent, it is characterised in that the composition
As anti-dandruff and itching-relieving agent in hair washing product, wherein the weight percent dosage of compound natural anti-dandruff and itching-relieving washing lotion to be 0.1%
~25%。
7. composition according to claim 6 is in the application for preparing anti-dandruff and itching-relieving agent, it is characterised in that the composition
As anti-dandruff and itching-relieving agent in hair washing product, wherein the weight percent dosage of compound natural anti-dandruff and itching-relieving washing lotion 5% ~
25%。
8. the preparation process of compound natural plant anti-dandruff stopping itching shampoo according to claim 8, using conventional shampoo
Technique preparation, adjusting pH value is 5.5 ~ 7.5.
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Application publication date: 20190614 |