CN109821117B - Powder release device and method - Google Patents
Powder release device and method Download PDFInfo
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- CN109821117B CN109821117B CN201711177479.6A CN201711177479A CN109821117B CN 109821117 B CN109821117 B CN 109821117B CN 201711177479 A CN201711177479 A CN 201711177479A CN 109821117 B CN109821117 B CN 109821117B
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- 239000000843 powder Substances 0.000 title claims abstract description 78
- 238000000034 method Methods 0.000 title abstract description 6
- 239000002775 capsule Substances 0.000 claims abstract description 362
- 230000000149 penetrating effect Effects 0.000 claims description 9
- 238000013022 venting Methods 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 19
- 230000001771 impaired effect Effects 0.000 abstract description 4
- 230000004202 respiratory function Effects 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 4
- 239000013066 combination product Substances 0.000 description 4
- 229940127555 combination product Drugs 0.000 description 4
- 239000013543 active substance Substances 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 229940112141 dry powder inhaler Drugs 0.000 description 3
- 230000009977 dual effect Effects 0.000 description 3
- 230000003434 inspiratory effect Effects 0.000 description 3
- 239000003595 mist Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000004080 punching Methods 0.000 description 2
- 238000012387 aerosolization Methods 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229940124630 bronchodilator Drugs 0.000 description 1
- 239000000168 bronchodilator agent Substances 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a powder releasing device and a method, wherein a deflection air inlet channel is arranged in a capsule chamber of a capsule type powder releasing device, so that spiral air flow is manufactured when a user inhales, the starting flow rate of capsule rotation is reduced, the user can release medicine by rotating the capsule at a high speed by providing a small inspiration flow, and a way is provided for children under 5 years old and patients with impaired respiratory function to use the capsule type DPI.
Description
Technical Field
The invention belongs to the field of medical instruments, relates to a powder release device and a powder release method, and particularly relates to a capsule type powder release device.
Background
The use of Dry Powder Inhalers (DPIs) for bronchodilators is well known, which are typically driven by the patient's inspiratory flow and aerodynamically disperse the drug into an inhalable powder.
A capsule type dry powder inhaler is a known dry powder inhaler comprising a capsule chamber and an actuator for opening the capsule chamber, the opening of the capsule being mainly achieved by shear force, needling or cutting, wherein needling is the most common opening mechanism, such as the capsule type inhaler disclosed in US 8196578 B2.
For capsule DPIs of the needle punching mechanism, the powder contained in the capsule is released during aerosolization by the needle punching of the capsule, and when the patient inhales to generate sufficient flow, the capsule begins to rotate and vibrate within the capsule chamber, and as the flow of inhalation increases, the rotational speed of the capsule will increase, thereby generating sufficient centrifugal force to release the powder from the capsule. Thus, capsule DPIs also suffer from insufficient inspiratory flow for patients with impaired ability to generate adequate inspiratory flow, and are not generally recommended for children under 5 years of age and for patients with impaired partial respiratory function.
In addition, combination therapies involving different and complementary active agents are also known, and at present, not just two, but even three or four active agents have emerged. While combination products provide additional convenience to the patient, certain pharmaceutical actives are difficult to formulate into unique combination products. For example, when formulated together, the actives may chemically interact with each other to have a negative impact.
The applicant has found that a capsule-type dry powder inhaler comprising at least two capsule compartments, each loaded with a capsule containing a different pharmaceutically active substance, and an actuation part matching the number of capsule compartments, provides an effective way to solve the above-mentioned problems, by mixing the powder released by the capsules in each capsule compartment, a combined inhaled medicament product for administration to a patient is provided.
Disclosure of Invention
In one aspect the present invention provides a powder delivery device for inhalation administration comprising:
A capsule chamber which is a cylindrical chamber capable of vertically accommodating a capsule, and the top of which is open;
an actuation portion comprising a spike mounted for movement towards the capsule chamber side wall to puncture the capsule, at least a portion of the actuation portion being located outside the device for manipulation by a user;
the suction nozzle is provided with an air outlet channel which extends downwards from top, a screen cover is fixed at the bottom opening of the air outlet channel, a screen is embedded in the screen cover and is detachably connected to the top of the capsule chamber, so that the screen covers the top of the capsule chamber;
The capsule chamber is provided with a deflection air inlet channel group communicated with the outside air at the bottom and/or the side wall of the capsule chamber, and the deflection air inlet channel group comprises at least two deflection air inlet channels which are distributed around the central axis of the capsule chamber and synchronously deflect clockwise or anticlockwise so as to provide spiral air flow which moves upwards from the deflection air inlet channels when a user inhales.
Preferably, the lower side of the screen protrudes towards the capsule chamber.
Preferably, the bottom of the capsule chamber is provided with an air inlet channel which is opened upwards and communicated with the outside air so as to provide air flow from bottom to top.
Further preferably, the air inlet channel at the bottom of the capsule chamber is opened upwards along the central axis of the capsule chamber.
Further preferably, the air inlet channel at the bottom of the capsule chamber is a deflection air inlet channel group.
Further preferably, the set of deflection air intake passages is integrally arranged at the bottom as a fixed impeller structure.
Further preferably, the opening of the deflection air inlet channel is tangential to the side wall of the capsule chamber.
Preferably, the side wall of the capsule chamber is provided with a deflection air inlet channel group.
Further preferably, a deflection air inlet channel group is arranged at the lower part of the side wall of the capsule chamber.
Further preferably, the opening of the deflection air inlet channel is tangential to the side wall of the capsule chamber.
Preferably, a set of deflection air inlet channels formed by two deflection air inlet channels is arranged at the lower part of the side wall of the capsule chamber, and a direct current air inlet channel is arranged at the bottom of the capsule chamber.
Preferably, the diameter of the capsule chamber is 1.1 to 2.5 times of the diameter of the capsule, and the height is 1.02 to 2.0 times of the height of the capsule.
Further preferably, the capsule chamber has a diameter of 1.2 to 1.5 times the capsule diameter and a height of 1.05 to 1.3 times the capsule height.
In a specific embodiment of the invention, the capsule chamber has a diameter of 1.35 times the diameter of the capsule and a height of 1.15 times the height of the capsule.
Preferably, the side wall of the capsule chamber is provided with a first deflection air inlet channel group, and the bottom of the capsule chamber is provided with a second deflection air inlet channel group.
In another aspect, the present invention provides a method of releasing inhalable powder in a capsule using the powder release device described above.
The medicine powder releasing device of the invention reduces the starting flow rate of the rotation of the capsule by arranging the deflection air inlet channel in the capsule chamber so as to reduce the starting flow rate of the rotation of the capsule when a user inhales, so that the user can release medicine by rotating the capsule at a high speed by providing less inhalation flow, and a way is provided for children under 5 years old and patients with impaired respiratory function to use the capsule DPI.
In a third aspect the present invention provides a dry powder inhalation device comprising:
the capsule chamber is a cylindrical containing chamber capable of vertically containing capsules, and the top of the capsule chamber is open, and the bottom and/or the side wall of the capsule chamber is provided with an air inlet channel communicated with the outside air;
An actuation portion comprising a spike mounted for movement by a user to a capsule chamber side wall for puncturing the capsule;
the suction nozzle comprises an air outlet channel below the suction nozzle;
The number of the capsule chambers is two to four, all the capsule chambers are arranged in parallel to form a multi-capsule chamber integrally, actuating parts are independently or commonly arranged among the capsule chambers, the actuating parts are provided with pricking needles at least the same as the number of the matched capsule chambers in the width direction, a screen cover is fixed at the bottom of an air outlet channel below the suction nozzle, a screen is fixed in the screen cover and is detachably connected to the tops of the multi-capsule chambers, so that the screen covers the tops of all the capsule chambers.
Preferably, the side wall of the air outlet channel is provided with at least one small hole communicated with the outside air, and the small hole is arranged in a direction not facing the central axis of the air outlet channel so as to promote the air flow in the air outlet channel to rotate when a user inhales.
Preferably, the diameter of the air outlet channel is gradually reduced from bottom to top, a narrow neck is formed before the air outlet channel reaches the suction nozzle, and the small hole of the air outlet channel is arranged at the lower side of the narrow neck.
Further preferably, the number of the small holes on the side wall of the air outlet channel is two, and the small holes are symmetrically arranged around the central axis of the air outlet channel.
Preferably, the bottom of each capsule chamber is provided with an air inlet channel to provide a bottom-up air flow when the user inhales.
It is further preferred that the air inlet channel at the bottom of the capsule chamber is a deflection air inlet channel group comprising at least two deflection air inlet channels arranged around the central axis of the capsule chamber and deflected synchronously in a clockwise or counter-clockwise direction to provide a helical air flow from bottom to top upon inhalation by the user.
In a specific embodiment of the application, the deflecting intake channel at the bottom of each capsule chamber is arranged as a whole as a fixed impeller structure.
Preferably, each capsule chamber side wall is provided with a deflection air inlet channel group respectively, and the deflection air inlet channel group comprises at least two deflection air inlet channels which are distributed around the central axis of the capsule chamber and synchronously deflect clockwise or anticlockwise so as to provide spiral air flow moving upwards from the deflection air inlet channels when a user inhales
Further preferably, the deflection air inlet channel group is arranged at the lower part of the side wall of the capsule chamber.
Further preferably, the opening direction of the deflection air inlet passage is tangential to the side wall of the capsule chamber.
Further preferably, the number of the deflection air intake passages of the deflection air intake passage group is two.
Preferably, the size of the inlet channel and/or the top opening of the at least one capsule chamber is different from the other capsule chambers, so that the air flow rate in the capsule chamber is different from the other capsule chambers.
It is further preferred that the air inlet passage aperture of the at least one capsule chamber is different from the other capsule chambers so that the air flow rate in the capsule chamber is different from the other capsule chambers.
Preferably, the diameter of the capsule chamber is 1.1 to 2.5 times of the diameter of the capsule, and the height is 1.02 to 2.0 times of the height of the capsule.
Further preferably, the capsule chamber has a diameter of 1.2 to 1.5 times the capsule diameter and a height of 1.05 to 1.3 times the capsule height.
In a specific embodiment of the invention, the capsule chamber has a diameter of 1.35 times the diameter of the capsule and a height of 1.15 times the height of the capsule.
Preferably, the multiple capsule chambers are composed of a first capsule chamber and a second capsule chamber which are closely arranged, a first actuating part and a second actuating part are arranged at two ends of a connecting line of the first capsule chamber and the second capsule chamber, and the first actuating part and the second actuating part can move from two sides to the middle to respectively puncture capsules in the first capsule chamber and the second capsule chamber.
Preferably, the multiple capsule chambers are composed of a first capsule chamber and a second capsule chamber which are closely arranged, an actuating part is arranged on one side of a connecting line of the first capsule chamber and the second capsule chamber, and the actuating part comprises at least two needles in the width direction so as to puncture capsules in the first capsule chamber and the second capsule chamber at the same time.
Further preferably, the dry powder inhalation device has an air resistance value of 0.01-0.08KPa 0.5 minutes/liter.
Still more preferably, the dry powder inhalation device has an air resistance value of 0.02-0.05KPa 0.5 minutes/liter.
In one embodiment of the invention, the dry powder inhalation device has an air resistance value of 0.0325KPa 0.5 minutes/liter.
Preferably, the multiple capsule chambers are closely arranged into a triangle by the first capsule chamber, the second capsule chamber and the third capsule chamber, a first actuating part is arranged at one side of the connecting line of the first capsule chamber and the second capsule chamber, at least two needles are arranged at the first actuating part in the width direction and can move towards the multiple capsule chamber to puncture the capsules in the first capsule chamber and the second capsule chamber at the same time, and the third actuating part is arranged at one side of the third capsule chamber far away from the first capsule chamber and the second capsule chamber and can move along the vertical direction of the straight line of the first capsule chamber and the second capsule chamber to puncture the capsules in the third capsule chamber.
Further preferably, the dry powder inhalation device has an air resistance value of 0.015-0.073KPa 0.5 minutes/liter.
Still more preferably, the dry powder inhalation device has an air resistance value of 0.02 to 0.04KPa 0.5 minutes/liter.
In one embodiment of the invention, the dry powder inhalation device has an air resistance value of 0.0305KPa 0.5 minutes/liter.
Preferably, the multiple capsule chambers are closely arranged in a square by a first capsule chamber, a second capsule chamber, a third capsule chamber and a fourth capsule chamber, the first actuating part and the second actuating part are arranged on the central axis of the square and can move from two sides to the middle, and the first actuating part and the second actuating part comprise at least two needles in the width direction, so that the first actuating part simultaneously punctures capsules in the first capsule chamber and the second capsule chamber, and the second actuating part simultaneously punctures capsules in the third capsule chamber and the fourth capsule chamber.
Further preferably, the dry powder inhalation device has an air resistance value of 0.01-0.06KPa 0.5 minutes/liter.
Still more preferably, the dry powder inhalation device has an air resistance value of 0.015 to 0.035KPa 0.5 minutes/liter.
In one embodiment of the invention, the dry powder inhalation device has an air resistance value of 0.029KPa 0.5 minutes/liter.
Preferably, the dry powder inhalation device further comprises:
A lower housing defining a cavity with an open top for holding multiple capsule chambers, the side of the lower housing being provided with notches matching the number and position of the actuating parts so that at least a portion of each actuating part is located outside the device for operation by a user, and having ventilation air inlet holes at the side and/or bottom so that the internal cavity thereof can communicate with the outside air through slits or holes;
the connecting plate is covered on the top of the lower shell, a hollowed connecting port is arranged at the top of the multi-capsule chamber, and the screen cover is detachably arranged at the connecting port, so that the screen covers the top of each capsule chamber through the connecting port.
An upper housing extending downwardly from the top of the mouthpiece and defining an open-bottomed cavity surrounding the outlet passage and covering the adapter plate when the screen cover is mounted to the adapter.
Preferably, the indentations are widened and/or lengthened relative to the size of the actuation portion to provide the air intake apertures.
Preferably, the side wall of the air outlet channel is provided with at least one small hole communicated with the outside air, and the small hole is arranged in a direction not facing the central axis of the air outlet channel so as to promote the air flow in the air outlet channel to rotate when a user inhales.
Preferably, the upper shell, the lower shell and the connecting plate are connected together in a hinged manner through rotating shafts positioned on the same side.
Preferably, the connector plate is integrally formed with the capsule compartments, and the connector opening forms a top opening of each capsule compartment.
Preferably, the diameter of the air outlet channel is gradually reduced from bottom to top, and a narrow neck is formed before the air outlet channel reaches the suction nozzle.
Preferably, a slit or a hole is formed at the joint of the upper housing and the joint plate, so that the internal cavity of the upper housing can be communicated with the outside air through the slit or the hole;
Further preferably, the number of the small holes on the air outlet channel is two, and the small holes are symmetrically arranged around the central axis of the air outlet channel.
Further preferably, the small holes in the air outlet channel are located in the area below the narrow neck.
The dry powder inhalation device of the invention provides a medicament dispenser containing each active component (or a mixture thereof) of a combination product in a separated manner by arranging a plurality of capsule chambers which are arranged in parallel, and has simple structure and convenient operation. In addition, each capsule compartment may adjust parameters of the inlet and outlet channels according to the nature of the powder of the drug (composition) to set its proper mist particle distribution for each active ingredient.
Drawings
FIG. 1 is a structural exploded view showing a powder releasing device according to the present invention
FIG. 2 shows a cross-sectional view of a capsule compartment area of the powder delivery device of FIG. 1
FIG. 3 shows a cross-sectional top view of the capsule compartment area of FIG. 2
FIG. 4 shows a cross-sectional view of an alternative capsule compartment area of the powder delivery device of FIG. 1
FIG. 5 is a block diagram showing the lower half of the cross-section of the capsule chamber area shown in FIG. 4
FIG. 6 shows a cross-sectional view of an alternative capsule compartment area of the powder delivery device of FIG. 1
FIG. 7 shows a cross-sectional top view of the capsule compartment area of FIG. 6
FIG. 8 shows a cross-sectional view of a capsule compartment area of the powder delivery device of FIG. 1
FIG. 9 shows a cross-sectional top view of the capsule compartment area of FIG. 8
FIG. 10 shows an enlarged view of a portion of the impeller at the bottom of the capsule chamber of the present invention
FIG. 11 shows a cross-sectional view of an alternative capsule compartment area of the powder delivery device of FIG. 1
FIG. 12 shows a cross-sectional top view of the capsule compartment area of FIG. 11
Figure 13 shows a structural exploded view of a dry powder inhalation device according to the present invention
Figure 14 shows a partial cross-sectional view of the dry powder inhalation device of figure 13
Figure 15 shows a perspective view of the mouthpiece of the dry powder inhalation device of figure 13
Figure 16 shows a perspective view of a screen housing of the dry powder inhalation device of figure 13
Figure 17 shows a cross-sectional top view of a multi-capsule chamber of the dry powder inhalation device of figure 13
Figure 18 shows a cross-sectional top view of a multi-capsule chamber of another dry powder inhalation device of the present invention
Figure 19 shows a cross-sectional top view of a multi-capsule chamber of another dry powder inhalation device of the present invention
Detailed Description
The invention is described in further detail below in connection with the following detailed description. It should not be construed that the scope of the above subject matter of the present invention is limited to the following embodiments, and all techniques realized based on the present invention are within the scope of the present invention.
Referring to fig. 1, 2 and 3, fig. 1 is a specific embodiment of a drug powder releasing device according to the present invention, comprising: (a) The capsule chamber 1 is a cylindrical containing chamber for containing capsules, the top of the capsule chamber 1 is provided with an air outlet channel 11, and the joint of the air outlet channel 11 and the capsule chamber 1 is provided with a screen 12 capable of ventilating. (b) An actuation part 2 comprising at least one lancet 21 mounted movable towards the capsule chamber 1 for puncturing the capsule, at least a portion of said actuation part 2 being located outside the device for manipulation by a user. (c) A mouthpiece 3 connected to the top of the capsule housing 1 via an outlet passage 11. Referring to fig. 2, the capsule chamber 1 is provided with a deflection air inlet channel group communicated with the outside air, and referring to fig. 3, the deflection air inlet channel group comprises at least two deflection air inlet channels 13 which are arranged around the central axis of the capsule chamber and synchronously deflect clockwise or anticlockwise, so as to provide spiral air flow moving from the deflection air inlet channel group to the top air outlet channel 11 when a user inhales.
In this embodiment, the user first opens the screen 12 mounted above the capsule chamber 1 and puts the capsule therein, then presses the actuating portion 2 to pierce the capsule, then resets the actuating portion 2 by manual or elastic means, and since the mouthpiece 3 communicates with the capsule chamber 1 through one of the air outlet passages 11 and the capsule chamber 1 communicates with the external environment through the set of deflected air inlet passages, when the user inhales, the external environment air generates a spiral air flow around the capsule chamber 1 through the set of deflected air inlet passages, facilitating the rapid rotation of the pierced capsule to release the inhalable powder contained therein, the inhalable powder moves with the air flow toward the air outlet passage 11 at the top of the capsule chamber 1 and enters the user's body through the mouthpiece 3.
It should be noted that the deflection air intake passages 13 of the present embodiment deflect clockwise or counterclockwise, and do not represent that the deflection air intake passage group must be opened in a horizontal direction, as long as it can provide a part of the air flow deflected in the horizontal direction, and of course, the at least two deflection air intake passages 13 should deflect synchronously, for example, when the deflection air intake passages 13 are located on the side walls, they should all face obliquely upward, all face obliquely downward, or all face in the horizontal direction.
Compared with the prior art, the medicine powder releasing device of the embodiment greatly reduces the requirement on the inhalation flow of a user during rotary medicine releasing of the capsule in the prior art by arranging the deflection air inlet channel group in the capsule chamber 1, so that the medicine powder is easier to release, and the residual quantity is reduced.
Further preferably, referring to fig. 1, in one embodiment, the underside of the ventable screen 12 protrudes toward the capsule chamber 1, and this shape provides a capsule rotational interface that reduces drag.
Further preferably, referring to fig. 2 and 3, in one embodiment, the deflection air inlet channel group is disposed on a side wall of the capsule chamber 1, and the bottom of the capsule chamber 1 is further provided with an air inlet channel 14 communicating with the outside air, which is opened upward along the central axis of the capsule chamber 1, so as to provide a penetrating air flow penetrating the capsule chamber 1 from bottom to top.
In this embodiment, the air inlet channel 14 at the bottom of the capsule chamber 1 can provide a through air flow through the whole capsule chamber 1 from bottom to top to help the top of the capsule rotate against the air-permeable screen 12 at the top of the capsule chamber 1 and to make the powder released by the capsule move more smoothly towards the top air outlet channel 11.
Further preferably, referring to fig. 4 and 5, in one embodiment, the deflection air inlet channel group is disposed at the lower part of the side wall of the capsule chamber 1, and the bottom of the capsule chamber 1 is further provided with an air inlet channel 14 which is opened upwards along the central axis of the capsule chamber 1 to provide a penetrating air flow penetrating the capsule chamber 1 from bottom to top.
The arrangement of the deflection air inlet channel group at the lower part of the side wall of the capsule chamber 1 can better provide the penetrating air flow penetrating the whole capsule chamber 1 from bottom to top so as to help the top end of the capsule to rotate against the screen 12 ventilated at the top of the capsule chamber 1 and enable the released powder to move more smoothly towards the top air outlet channel 11.
Further preferably, referring to fig. 6 and 7, in one embodiment, the deflection air intake channel group is provided in a lower portion of the side wall of the capsule chamber 1, and the bottom of the capsule chamber 1 is not provided with an air intake channel 14.
The provision of the deflection inlet channel group only in the lower part of the side wall of the capsule chamber 1 also provides a fully bottom-up air flow to assist the rotation of the screen 12 venting the top of the capsule against the top of the capsule chamber 1, it being understood that a through air flow is not necessary for the rotation of the screen 12 venting the top of the capsule against the top of the capsule chamber 1, as long as a bottom-up non-through air flow is sufficient for the capsule to be lifted.
Referring to fig. 8, 9 and 10, in another embodiment of a powder releasing device of the present invention, a deflecting air inlet channel group is provided at the bottom of the capsule chamber 1.
In this embodiment, the deflecting air inlet channel group at the bottom of the capsule chamber 1 can be uniformly distributed around the central axis of the capsule chamber 1, and deflect synchronously clockwise or anticlockwise, which can provide a part of spiral airflow deflected horizontally to help the capsule to release medicine by rotating, and can also provide another part of penetrating airflow from bottom to top to help the top of the capsule to rotate against the screen 12 ventilated at the top of the capsule chamber 1, and make the released powder move more smoothly towards the top air outlet channel 11.
Further preferably, referring to fig. 9 and 10, in one embodiment, the bottom set of deflection intake passages is integrally arranged as a fixed impeller structure.
In the present embodiment, the deflection air intake passage group of the impeller structure of the bottom of the capsule chamber 1 can be understood as being constituted by four deflection air intake passages 13 divided by four vanes.
Further preferably, referring to fig. 11 and 12, in one embodiment both the bottom and the side walls of the capsule chamber 1 are provided with a set of deflection air inlet channels.
In this embodiment, the deflecting air inlet channel group at the bottom of the capsule chamber 1 and the deflecting air inlet channel group at the side wall both play a role in providing deflecting air flow, and the deflecting air inlet channel group at the bottom can also provide penetrating air flow from bottom to top, so that the purpose of the invention can be achieved.
Referring to fig. 13 and 14, a dry powder inhalation device according to an embodiment of the present invention comprises: (a) The capsule chamber 1 is a cylindrical containing chamber capable of vertically containing capsules, the top of the capsule chamber 1 is open, and the bottom of the capsule chamber is provided with an air inlet channel 14 communicated with the outside air; (b) An actuating portion 2 comprising a spike 21 mounted for movement by a user to the side wall of the capsule chamber 1 for puncturing the capsule; (c) The suction nozzle 3, see fig. 13, 15, comprises an air outlet channel 11 below (for clarity of illustration, the lower part of the air outlet channel 11 in fig. 13 is cut away for separate illustration); the number of the two capsule chambers 1 is two, the two capsule chambers 1 are arranged in parallel to form a double capsule chamber formed integrally, an actuating part 2 is separately arranged between the capsule chambers 1, each actuating part 2 is provided with two pricking needles 21 in the height direction, a screen cover 15 is fixed at the opening of the bottom of the air outlet channel 11, and referring to fig. 16, a screen 12 is fixed in the screen cover 15 and detachably connected to the top of the double capsule chamber, so that the screen 12 covers the tops of the two capsule chambers 1.
In this embodiment, the dual capsule chambers are composed of a first capsule chamber 1a and a second capsule chamber 1b which are closely arranged, and a first actuating part 2a and a second actuating part 2b are arranged at two ends of a connecting line of the first capsule chamber 1a and the second capsule chamber 1b, and the first actuating part 2a and the second actuating part 2b can move from two sides to the middle to puncture capsules in the first capsule chamber 1a and the second capsule chamber 1b respectively.
The user firstly separates the screen cover 15 from the top of the double capsule chambers so as to open the tops of the double capsule chambers, and closes the screen cover 15 after filling capsules containing two different active ingredients into each capsule chamber 1 respectively so as to enable the screen 12 to cover the tops of the capsule chambers 1 again; subsequently, the user operates the actuating portion 2 to move from both sides to the middle to pierce the capsules in the first capsule chamber 1a and the second capsule chamber 1b, respectively, the actuating portion 2 being reset by an elastic member commonly used in the prior art; finally, the user closely attaches the mouth part to the suction nozzle 3 and forcibly sucks air, and external air enters the capsule chamber through the air inlet channel 14 at the bottom of the capsule chamber 1, so that the capsule is abutted against the screen 12 to vibrate and rotate to release powder, and the released powder in the capsule enters the air outlet channel 11 through the screen 12 and finally enters a human body.
Although the actuating portion 2 of the present embodiment moves from both sides to the middle to pierce the capsules in the first capsule chamber 1a and the second capsule chamber 1b, respectively, a person skilled in the art may adjust the arrangement of the actuating portion, for example, the actuating portion 2 is arranged at one side of the line where the first capsule chamber 1a and the second capsule chamber 1b are located, and the actuating portion 2 includes at least two lancets in the width direction so as to pierce the capsules in the first capsule chamber 1a and the second capsule chamber 1b simultaneously by one actuating portion 2 when operated.
Further preferably, referring to fig. 17, in one embodiment, each capsule chamber 1 sidewall is provided with a set of deflection air intake passages comprising two deflection air intake passages 13 arranged around the central axis of the capsule chamber 1 and synchronously deflected in a clockwise or counter-clockwise direction to provide a helical air flow moving upwardly from the deflection air intake passages 13 upon inhalation by the user.
Compared with the previous embodiment, the powder releasing device of the present embodiment provides the spiral air flow moving upwards from the deflecting air inlet channel 13 by arranging the deflecting air inlet channel group on the side wall of the capsule chamber 1, and the air flow can more smoothly help the capsule to rotate, so that the requirement on the inhalation flow of the user during the capsule rotating releasing in the prior art is greatly reduced, and the powder releasing is easier.
Further preferably, referring to fig. 13 and 14, in one embodiment, the set of deflection air intake passages is provided in a lower portion of the side wall of each capsule chamber 1.
In comparison with the previous embodiments, the powder releasing device of the present embodiment can not only provide a spiral air flow moving upward from the deflecting air inlet channel 13, but also assist the bottom air inlet channel 14 to push the capsule against the top screen 12 of the capsule chamber by providing the deflecting air inlet channel group at the lower part of the capsule chamber 1.
Further preferably, referring to fig. 17, in one embodiment, the opening direction of the deflecting air inlet channel 13 is tangential to the side wall of each capsule chamber 1, so that the spiral air flow more smoothly rotates the capsules
Further preferably, referring to fig. 13, in one embodiment, the dry powder inhalation device further comprises:
(d) A lower housing 4 defining a cavity open at the top for accommodating the dual capsule chamber, the side of the lower housing 4 being provided with two notches 41 so that at least a portion of the actuating portion 2 is located outside the device for operation by a user, the notches 41 being extended and widened downward with respect to the size of the actuating portion 2 to provide air intake holes 42 through which the internal cavity can communicate with the outside air; (e) A joint plate 5 covering the top of the lower housing 4, a hollowed joint 51 is provided at the top of the multi-capsule chamber, and a screen cover 15 is detachably mounted to the joint 51 so that the screen 12 covers the top of each capsule chamber 1, see fig. 13 and 14. Referring to fig. 13 and 15, (f) an upper housing 6 extending downwardly from the top of the mouthpiece 3 defines a cavity open at the bottom surrounding the outlet channel 11 and which fits over the adaptor plate 5 when the screen cover 15 is fitted to the adaptor.
The user first separates the lower and upper cases 4 and 6 to separate the screen cover 15 from the top of the dual capsule chambers, and then closes the upper and lower cases 6 and 4 after filling each capsule chamber 1 with capsules containing two different active ingredients, respectively, so that the screen 12 covers the top of the capsule chamber 1 again; then, the user operates the portion of the actuating portion 2 located outside the housing to pierce the capsules in each capsule chamber 1, the actuating portion 2 being reset by means of elastic members commonly used in the prior art; finally, the user closely attaches the mouth to the suction nozzle 3 and sucks air forcefully, external air enters the cavity through the air inlet hole 42 of the lower shell 4 and enters the capsule chamber 1 from the air inlet channel 14 at the bottom of the capsule chamber 1, so that the capsule is abutted against the screen 12 to vibrate and rotate to release powder, and the released powder in the capsule enters the air outlet channel 11 through the small holes of the screen 12 and finally enters a human body.
Compared with the previous embodiment, the dry powder inhalation device of the present embodiment adds the upper housing 6, the lower housing 4 and the engagement plate 5 on the premise of supporting the technical solution of the previous embodiment, thereby increasing the structural firmness of the device and facilitating the operation.
Further preferably, referring to fig. 13, 14 and 15, in one embodiment, a slit 52 is provided at the junction of the upper housing 6 and the adapter plate 5 so that the internal cavity thereof can communicate with the outside air through the slit 52. The side wall of the air outlet channel 11 is provided with a small hole 111, and the small hole 111 is opened in a direction not facing the central axis of the air outlet channel 11 so as to promote the air flow in the air outlet channel 11 to rotate when a user inhales.
When the user inhales, external air can enter the inner cavity of the upper shell 6 through the slit and enter the air outlet channel 11 from the small hole 111 of the air outlet channel 11, so that the air flow in the air outlet channel 11 is rotated, and after the capsule medicine powder in each capsule chamber 1 of the embodiment is released, the capsule medicine powder is transported in the air outlet channel 11 and fully mixed through rotation, so that the movement speed and the components are proper and uniform when reaching the suction port 3.
Further preferably, referring to fig. 14, in one embodiment, the outlet channel 11 gradually decreases in diameter from bottom to top, and a narrow neck 112 is formed before reaching the outlet, so that the medicine powder reaches the mouthpiece 3 at a proper speed and with a uniform composition.
Referring to fig. 18, another embodiment of the dry powder inhalation device of the present invention is that the multiple capsule chambers are closely arranged in a triangle by the first capsule chamber 1a, the second capsule chamber 1b and the third capsule chamber 1c, the first actuating part 2a is arranged at one side of the line where the first capsule chamber 1a and the second capsule chamber 1b are located, the first actuating part 2a is arranged with two needles 21 in the width direction and is movable toward the multiple capsule chambers to pierce the capsules in the first capsule chamber 1a and the second capsule chamber 1b at the same time, and the second actuating part 2c is arranged as one side of the third capsule chamber 1c away from the first capsule chamber 1a and the second capsule chamber 1b and is arranged to be movable in the perpendicular direction of the line where the first capsule chamber 1a and the second capsule chamber 1b are located to pierce the capsules in the third capsule chamber 1 c.
By providing three capsule chambers in this embodiment, a medicament dispenser is provided which contains three active components (or mixtures thereof) of the combination product in a separate manner, wherein the bottom of each capsule chamber 1 is provided with an air inlet channel 14, the sides or bottom are not provided with a set of deflection air inlet channels, and other components are arranged in the same or similar manner as in the other embodiments, and are not described in detail herein.
It is further preferred, see fig. 18, that in one embodiment the aperture of the bottom inlet channel 14 of one capsule chamber 1 is different from the other two capsule chambers 1, such that the inlet air flow rate of that capsule chamber 1 is different from the other capsule chambers 1.
In some cases, the components of the combination product need to achieve a specific mist particle distribution to maximize the effect, and since each component of the invention is released separately in the corresponding capsule chamber 1, by adjusting the size, position, opening angle and/or number of the deflection air inlet channel 13, air inlet channel 14 and/or air outlet channel 11, different aerodynamic parameters can be set for each capsule chamber 1, respectively, to maximize the therapeutic effect of each active ingredient under the premise of simultaneous administration. In this embodiment, the size of the air inlet channel 14 at the bottom of the capsule chamber 1 is adjusted to give different air flow rates to influence the mist particle distribution of the powder in the capsule.
Referring to fig. 19, which is another embodiment of the dry powder inhalation device of the present invention, the multiple capsule chambers 1 are closely arranged in a square by a first capsule chamber 1a, a second capsule chamber 1b, a third capsule chamber 1c and a fourth capsule chamber 1d, the first actuating portion 2a and the second actuating portion 2b are arranged on the central axis of the square and are movable from both sides to the middle, and the first actuating portion 2a and the second actuating portion 2b include at least two needles 21 in the width direction so that the first actuating portion 2a punctures the capsules in the first capsule chamber 1a and the second capsule chamber 1b at the same time, and the second actuating portion 2b punctures the capsules in the third capsule chamber 1c and the fourth capsule chamber 1d at the same time.
This embodiment provides a medicament dispenser containing four active components (or mixtures thereof) of the combination product in a separate manner by providing four capsule compartments. The four capsule chambers are arranged to cause the inhalation device to have higher requirement on the inhalation flow of a patient, and in order to enable the capsules to fully rotate and release medicine, the bottom of each capsule chamber 1 of the embodiment is provided with a deflection air inlet channel group which is integrally arranged into a fixed impeller structure so as to provide spiral air flow from bottom to top when a user inhales, and the capsule rotating and releasing medicine is effectively promoted, wherein the specific shape of the impeller structure can be referred to as fig. 10.
The foregoing is merely illustrative of the present invention and is not intended to limit the scope of the invention. Any equivalent alterations, modifications and combinations thereof will be effected by those skilled in the art without departing from the spirit and principles of this invention, and it is intended to be within the scope of the invention.
Claims (11)
1. A powder delivery device for inhalation administration comprising:
A capsule chamber (1) which is a cylindrical chamber capable of vertically accommodating a capsule, wherein the top of the capsule chamber (1) is open;
An actuation portion (2) comprising at least one spike (21) mounted movable towards the capsule chamber (1) side wall to spike the capsule, at least a portion of said actuation portion (2) being located outside the device for manipulation by a user;
The suction nozzle (3) comprises an air outlet channel (11) below, a screen cover (15) is fixed at the bottom of the air outlet channel (11), a screen (12) is embedded in the screen cover (15), and the screen is detachably connected to the top of the capsule chamber (1) so that the screen (12) covers the top of the capsule chamber (1);
It is characterized in that the bottom and/or the side wall of the capsule chamber (1) is provided with a deflection air inlet channel group communicated with the outside, the deflection air inlet channel group comprises at least two deflection air inlet channels (13) which are distributed around the central axis of the capsule chamber (1) and synchronously deflect clockwise or anticlockwise so as to provide spiral air flow which moves upwards from the deflection air inlet channels (13) when a user inhales,
The bottom of the capsule chamber (1) is provided with an air inlet channel (14) which is arranged upwards and communicated with the outside air, and the air inlet channel is arranged upwards along the central axis of the capsule chamber (1) and provides a penetrating air flow which penetrates the capsule chamber (1) from bottom to top so as to help the top of the capsule to prop against a screen (12) which is ventilated at the top of the capsule chamber (1) for rotation;
The diameter of the capsule chamber (1) is 1.1 to 2.5 times of the capsule diameter, and the height is 1.02 to 2.0 times of the capsule height.
2. The powder release device according to claim 1, wherein the underside of the venting screen (12) protrudes towards the capsule chamber (1).
3. The powder releasing device according to claim 1, wherein the air inlet channel at the bottom of the capsule chamber (1) is a set of deflection air inlet channels.
4. A powder delivery device according to claim 3, wherein the set of deflection inlet channels at the bottom of the capsule chamber (1) is integrally arranged as a fixed impeller structure.
5. A powder releasing device according to claim 1, wherein the capsule chamber (1) side wall is provided with a set of deflection air inlet channels.
6. The powder delivery device of claim 5, wherein the opening of the deflection air inlet channel (13) of the capsule chamber (1) side wall is tangential to the capsule chamber (1) side wall.
7. The powder releasing device according to claim 6, wherein the deflection air inlet channel group is located at a lower portion of a side wall of the capsule chamber (1).
8. The powder releasing device according to claim 7, wherein a lower portion of the side wall of the capsule chamber (1) is provided with a set of deflection air intake passages consisting of two deflection air intake passages, and a direct current air intake passage is provided at the bottom of the capsule chamber (1).
9. The powder releasing device according to claim 1, wherein the capsule chamber (1) has a diameter of 1.2 to 1.5 times the capsule diameter and a height of 1.05 to 1.3 times the capsule height.
10. The powder releasing device according to claim 9, wherein the capsule chamber (1) has a diameter of 1.35 times the capsule diameter and a height of 1.15 times the capsule height.
11. The powder releasing device according to claim 1, wherein the number of deflection air inlet channels (13) of the deflection air inlet channel group of the capsule chamber (1) is two.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711177479.6A CN109821117B (en) | 2017-11-23 | 2017-11-23 | Powder release device and method |
| CN201880074883.7A CN111356495B (en) | 2017-11-23 | 2018-11-22 | Powder delivery device and method |
| PCT/CN2018/116943 WO2019101136A1 (en) | 2017-11-23 | 2018-11-22 | Powder release device and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711177479.6A CN109821117B (en) | 2017-11-23 | 2017-11-23 | Powder release device and method |
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| CN109821117A CN109821117A (en) | 2019-05-31 |
| CN109821117B true CN109821117B (en) | 2024-06-28 |
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| CN201711177479.6A Active CN109821117B (en) | 2017-11-23 | 2017-11-23 | Powder release device and method |
| CN201880074883.7A Active CN111356495B (en) | 2017-11-23 | 2018-11-22 | Powder delivery device and method |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201880074883.7A Active CN111356495B (en) | 2017-11-23 | 2018-11-22 | Powder delivery device and method |
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| WO (1) | WO2019101136A1 (en) |
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| CN110812635A (en) * | 2019-11-18 | 2020-02-21 | 德必来福有限公司 | Administration device for inhaling powder inhalation |
| CN111388814A (en) * | 2020-05-22 | 2020-07-10 | 苏州新劢德医疗器械科技有限公司 | Powder inhaler device |
| CN115006698A (en) * | 2020-12-14 | 2022-09-06 | 梁瑶 | respiratory sac |
| CN114986290A (en) * | 2022-06-22 | 2022-09-02 | 中航天建设工程集团有限公司 | Green energy-concerving and environment-protective type building construction equipment |
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- 2018-11-22 CN CN201880074883.7A patent/CN111356495B/en active Active
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| CN208389129U (en) * | 2017-11-23 | 2019-01-18 | 正大天晴药业集团股份有限公司 | A kind of powder release device |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN111356495A (en) | 2020-06-30 |
| CN109821117A (en) | 2019-05-31 |
| WO2019101136A1 (en) | 2019-05-31 |
| CN111356495B (en) | 2022-08-30 |
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Address after: No. 369, Yuzhou South Road, Lianyungang, Jiangsu Province Patentee after: CHIA TAI TIANQING PHARMACEUTICAL GROUP Co.,Ltd. Country or region after: China Address before: 222062 Yuzhou South Road, Haizhou District, Lianyungang, Jiangsu 369 Patentee before: CHIA TAI TIANQING PHARMACEUTICAL GROUP Co.,Ltd. Country or region before: China |