CN109744325A - A kind of nanoemulsion system and preparation method based on perilla oil or linseed oil - Google Patents
A kind of nanoemulsion system and preparation method based on perilla oil or linseed oil Download PDFInfo
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- 239000007908 nanoemulsion Substances 0.000 title claims abstract description 57
- 239000003921 oil Substances 0.000 title claims abstract description 54
- 235000019198 oils Nutrition 0.000 title claims abstract description 54
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- 239000000944 linseed oil Substances 0.000 title claims abstract description 47
- 235000021388 linseed oil Nutrition 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 244000124853 Perilla frutescens Species 0.000 title description 2
- 241000229722 Perilla <angiosperm> Species 0.000 claims abstract description 46
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- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical group CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 7
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- -1 wherein Substances 0.000 claims description 3
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- 238000000034 method Methods 0.000 abstract description 6
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- 241000699666 Mus <mouse, genus> Species 0.000 description 8
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 8
- 239000011780 sodium chloride Substances 0.000 description 6
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 2
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- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
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- 239000003146 anticoagulant agent Substances 0.000 description 1
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- 235000020669 docosahexaenoic acid Nutrition 0.000 description 1
- 229940090949 docosahexaenoic acid Drugs 0.000 description 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
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- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 1
- 229960005135 eicosapentaenoic acid Drugs 0.000 description 1
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
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- 235000021323 fish oil Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
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- 235000011194 food seasoning agent Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000007970 homogeneous dispersion Substances 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
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- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
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- 235000020195 rice milk Nutrition 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
A kind of nano-emulsion system and preparation method based on perilla herb oil or linseed oil of the invention belongs to food processing technology field.The nano-emulsion system includes perilla herb oil or linseed oil, surfactant, cosurfactant and water, and the partial size of nano-emulsion is 40~45nm；Preparation method includes the preparation of mixed surfactant, the preparation of thick lotion, the preparations of nanoemulsions, ultrasonic emulsification.Oil-in-water type nano-emulsion liquid prepared by the present invention, physical stability with higher, good storage stability, for perilla herb oil and linseed oil storage and it is anti-oxidant propose new method, improve the physiological absorption degree of perilla herb oil and linseed oil.
Description
Technical field
The invention belongs to food processing technology fields, are related to a kind of nano-emulsion liquid prepared by perilla herb oil or linseed oil
System and preparation method.
Background technique
Perilla herb oil rich in nutrition content does not contain only the fat-soluble functional component such as vitamin E, phytosterol, squalene, and so far
The highest vegetable oil of alpha-linolenic acid content found until the present has the function such as apparent antibacterial, antiallergy, anti-aging, reducing blood lipid
Energy.In addition to this, the volatile materials such as perillaldehyde, limonene contained in perilla herb oil assign its unique faint scent, increase to food
Taste plays an important role.Alpha-linolenic acid content is 53% in linseed oil, and alpha-linolenic acid is essential fatty acid, in human body
It can be converted into eicosapentaenoic acid and docosahexaenoic acid, they are the effective active composition in fish oil.Alpha-linolenic acid has anti-
The effects of tumour, antithrombotic, reducing blood lipid, nourishing brain cell, adjusting vegetative nerve, by more concern.
On the other hand, unsaturated fatty acid content is high in perilla herb oil and linseed oil, and a large amount of unsaturated fatty acid is easily
It is influenced by factors such as illumination, temperature, leads to the problem of oxidation deterioration, not only caused the loss of nutritional ingredient, also bring along flavor
Deterioration, to limit its application in food；And unsaturated fatty acid is macromolecular substances, and physiological absorption degree is poor,
It can not all absorb in vivo, cause the loss of nutritional ingredient.
Nanoemulsions by water, oil, surfactant and cosurfactant etc. spontaneously form the Thermodynamically stable formed,
Isotropism, transparent or semitransparent homogeneous dispersion system.Emulsion oil-in-water is that oil is passed through emulsifier as dispersed phase
Effect, is embedded in inside by water, so that starvation, delays to aoxidize, increases stability.
Summary of the invention
The purpose of the present invention is overcome the deficiencies of the prior art and provide a kind of nanometer prepared by perilla herb oil or linseed oil
The preparation method of emulsion system and the nanoemulsions, with the physiology for delaying perilla herb oil oxidation, improving perilla herb oil and linseed oil
Trap.
The present invention is to solve technical solution to adopt the following technical scheme that:
A kind of nano-emulsion system based on perilla herb oil or linseed oil, which is characterized in that the nano-emulsion system includes
Perilla herb oil or linseed oil, surfactant, cosurfactant and water, wherein the mass ratio of oil and water is 3:23~26, table
The mass percent for the total nano-emulsion of mixed surfactant Zhan that face activating agent and cosurfactant are formed is 19.4%~
21.2%；The partial size of nano-emulsion is 40~45nm；The surfactant is polyoxyethylene ether rilanit special -40, helps table
Face activating agent is Span 80.
A kind of preparation method of the nano-emulsion system based on perilla herb oil or linseed oil, there is following steps:
A) preparation of mixed surfactant: surfactant and cosurfactant is abundant according to the mass ratio of 3:1
Mixing；The surfactant is polyoxyethylene ether rilanit special -40, and hydrophilic lipophilic balance is 14~16, helps surface
Activating agent is Span 80, hydrophilic lipophilic balance 4.3；
B) preparation of thick lotion: oil is added in mixed surfactant, and after mixing well, distillation is at the uniform velocity added dropwise
Water obtains thick lotion after stirring；
C) preparation of nanoemulsions: obtained thick lotion is futher stirred into emulsifying, obtains nanoemulsions；
D) ultrasonic emulsification: being placed in ultrasonic cleaner for obtained nanoemulsions and further emulsify, and obtains stable receive
Rice milk liquid.
In step c), mixing speed preferably 10000 ± 1000r/min, the preferential 5 ± 1min of mixing time.
In step d), the preferred 500W of ultrasonic power handles time preferably 15 ± 1min.
The utility model has the advantages that
Oil-in-water type nano-emulsion liquid prepared by the present invention, physical stability with higher, good storage stability,
For perilla herb oil and linseed oil storage and it is anti-oxidant propose new method, the physiology for improving perilla herb oil and linseed oil is inhaled
Receipts degree can be used as nutritional supplement applied to many aspects such as health care product, drinks, cosmetics, medicine, also can be used as food
Seasoning be used for product flavouring, widened the application range of perilla herb oil and linseed oil, produce good social benefit and
Economic benefit.
Detailed description of the invention
Fig. 1 is purple perilla oil nanometer emulsion change of size curve under the conditions of 4 DEG C, 37 DEG C and 55 DEG C respectively.
Fig. 2 is the purple perilla oil nanometer emulsion change of size curve under condition of different pH respectively.
Fig. 3 is purple perilla oil nanometer emulsion change of size curve under the conditions of different NaCl concentrations respectively.
Fig. 4 is linseed oil nano-emulsion change of size curve under the conditions of 4 DEG C, 37 DEG C and 55 DEG C respectively.
Fig. 5 is the linseed oil nano-emulsion change of size curve under condition of different pH respectively.
Fig. 6 is linseed oil nano-emulsion change of size curve under the conditions of different NaCl concentrations respectively.
Fig. 7 is the mouse weight change curve in acute toxicity test in mice.
Fig. 8 is the mouse food-intake change curve in acute toxicity test in mice.
Fig. 9 is in acute toxicity test in mice, and each group mouse organs are sliced toxicological results.
Specific embodiment
Below with reference to embodiment, the invention will be further described, but these the examples are only for explaining the invention not
Any restrictions are constituted to protection scope of the present invention.
Nano-emulsion preparation system of the invention carrys out body to prepare the process of purple perilla oil nanometer emulsion and linseed oil nano-emulsion
It is existing.
The parent of surfactant polyoxyethylene ether hydride castor oil -40 (Cremorphor RH40) used in embodiment
Hydrophile-lipophile balance value (HLB value) is 14~16, the hydrophilic lipophilic balance (HLB value) of cosurfactant Span 80 (Span80)
It is 4.3.HLB value refers to the amount of the size and balance of power degree in emulsification molecule between hydrophilic group and lipophilic group, different
Surfactant can obtain a series of complexed surfactant of different HLB values by compounding.
The preparation of 1 purple perilla oil nanometer emulsion of embodiment
Cremorphor RH40 and Span80 is sufficiently mixed in magnetic stirring apparatus according to the mass ratio of 3:1, is stirred
Temperature is 60 ± 1 DEG C, and mixing time 5min obtains mixed surfactant；
Perilla herb oil and mixed surfactant are placed in magnetic stirring apparatus according to the mass ratio of 3:7 and mixed well, then with
The method of constant pressure titration is slowly added to distilled water, and thick lotion is obtained after stirring, and whipping temp is 60 ± 1 DEG C；
Obtained thick lotion is futher stirred into emulsifying, obtains nanoemulsions, stirring rate is 10000 ± 1000r/
Min, processing time are 5 ± 1min；
Obtained nanoemulsions are placed in ultrasonic cleaner further to emulsify, obtain stable nanoemulsions；Ultrasonic wave
Power is 500W, and the processing time is 15 ± 1min.
The average grain diameter of purple perilla oil nanometer emulsion manufactured in the present embodiment is 41.73nm, and the mass concentration of perilla herb oil is
9.1%, the mass percent that surfactant accounts for total emulsion is 21.2%.
Purple perilla oil nanometer emulsion manufactured in the present embodiment is stored 15 days under the conditions of 4 DEG C, 37 DEG C and 55 DEG C respectively, observes it
The variation of partial size, as shown in Figure 1.As shown in Figure 1, purple perilla oil nanometer emulsion stores under the conditions of 4 DEG C, 37 DEG C and 55 DEG C, surveys respectively
Its 1 day, 5 days and 15 days change of size very little is tried, illustrates purple perilla oil nanometer emulsion prepared by the present invention in low temperature and hot conditions
Under all have good stability.
The purple perilla oil nanometer emulsion is stored under the conditions of pH value 2,3,4...8,9,10 respectively, tests its 1 day and 7 days respectively
Change of size, as shown in Figure 2.As shown in Figure 2, the variation of perilla herb oil nano-emulsion particle diameter less, illustrates purple perilla prepared by the present invention
Oil nanometer emulsion all has good stability under strong acid and basic conditions.
The purple perilla oil nanometer emulsion is stored under the conditions of different NaCl concentrations respectively, tests the grain of its 1 day and 7 days respectively
Diameter observes the variation of its partial size, as shown in Figure 3.From the figure 3, it may be seen that purple perilla oil nanometer emulsion is respectively in different NaCl concentration conditions
7 days change of size of lower storage are little, illustrate that purple perilla oil nanometer emulsion prepared by the present invention has outstanding salt stability.
The preparation of 2 linseed oil nano-emulsion of embodiment
Cremorphor RH40 and Span80 is sufficiently mixed in magnetic stirring apparatus according to the mass ratio of 3:1, stirring temperature
Degree is 60 ± 1 DEG C, mixing time 5min；
Linseed oil and mixed surfactant are placed in magnetic stirring apparatus according to the mass ratio of 3:7 and mixed well, then
It is slowly added to distilled water in the method that constant pressure titrates, thick lotion is obtained after stirring, whipping temp is 60 ± 1 DEG C；
Obtained thick lotion is futher stirred into emulsifying, obtains nanoemulsions, stirring rate is 10000 ± 1000r/
Min, processing time are 5 ± 1min；
Obtained nanoemulsions are placed in ultrasonic cleaner further to emulsify, obtain stable nanoemulsions ultrasonic wave function
Rate is 500W, and the processing time is 15 ± 1min.
The average grain diameter of linseed oil nano-emulsion prepared by embodiment 2 is 44.77nm.The mass concentration of linseed oil is
8.3%, the mass percent that surfactant accounts for total emulsion is 19.4%.
Linseed oil nano-emulsion prepared by embodiment 2 stores 15 days under the conditions of 4 DEG C, 37 DEG C and 55 DEG C respectively, observation
The variation of its partial size, as shown in Figure 4.As shown in Figure 4, linseed oil nano-emulsion stores under the conditions of 4 DEG C, 37 DEG C and 55 DEG C, point
Its 1 day, 5 days and 15 days change of size very little is not tested, illustrates linseed oil nano-emulsion prepared by the present invention in low temperature and height
All there is good stability under the conditions of temperature.
The linseed oil nano-emulsion is stored under the conditions of pH value 2,3,4...8,9,10 respectively, tests it respectively 1 day and 7
It partial size, as a result as shown in figure 5, as seen from Figure 5, the variation of linseed oil nano-emulsion particle diameter less, illustrates prepared by the present invention
Linseed oil nano-emulsion all has good stability under strong acid and basic conditions.
The linseed oil nano-emulsion is stored under the conditions of different NaCl concentrations respectively, observes the variation of its partial size, such as Fig. 6
It is shown.It will be appreciated from fig. 6 that linseed oil nano-emulsion stores under the conditions of different NaCl concentrations respectively, it is tested respectively 1 day and 7
It change of size is little, illustrates that the linseed oil nano-emulsion that the present invention charts has outstanding salt stability.
Purple perilla oil nanometer emulsion and linseed oil nano-emulsion prepared by above-described embodiment 1 and embodiment 2 carries out chmice acute
Toxicity test is compared with common perilla herb oil and linseed oil, the changes of weight curve and food-intake change curve of mouse
It is as shown in Figure 7 and Figure 8 respectively.As it can be seen that each group food-intake is undifferentiated, but the Mice Body of edible purple perilla oil nanometer emulsion (PON)
The important mouse for being greater than edible perilla herb oil (PO)；Likewise, the mouse weight of edible linseed oil nano-emulsion (LON) is greater than food
With the mouse of linseed oil (LO).This illustrate the purple perilla oil nanometer emulsion that charts of the present invention and linseed oil nano-emulsion and perilla herb oil and
Linseed oil, which is compared, better rouge absorbability.
Mouse organs' slice map is it is found that each group organ shows prepared by the present invention without Pathologic changes as shown in Figure 9
Purple perilla oil nanometer emulsion and linseed oil nano-emulsion are nontoxic.
Claims (4)
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111388526A (en) * | 2020-03-23 | 2020-07-10 | 吉林大学 | A kind of preparation method of ursolic acid nanoemulsion |
| CN112956597A (en) * | 2021-04-13 | 2021-06-15 | 上海宠幸宠物用品有限公司 | Pet food containing alpha-linolenic acid and preparation method thereof |
| CN116350678A (en) * | 2023-05-18 | 2023-06-30 | 南京中医药大学 | Nanoemulsion for treating psoriasis dermatitis and preparation method and application thereof |
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| CN116350678A (en) * | 2023-05-18 | 2023-06-30 | 南京中医药大学 | Nanoemulsion for treating psoriasis dermatitis and preparation method and application thereof |
| CN116350678B (en) * | 2023-05-18 | 2024-07-26 | 南京中医药大学 | Nanoemulsion for treating psoriasis dermatitis and preparation method and application thereof |
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