CN109652691A - A kind of metal is sunken cord and the preparation method and application thereof - Google Patents
A kind of metal is sunken cord and the preparation method and application thereof Download PDFInfo
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- CN109652691A CN109652691A CN201910091354.4A CN201910091354A CN109652691A CN 109652691 A CN109652691 A CN 109652691A CN 201910091354 A CN201910091354 A CN 201910091354A CN 109652691 A CN109652691 A CN 109652691A
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- Prior art keywords
- metal
- cord
- sunken cord
- sunken
- treatment
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- 229910052751 metal Inorganic materials 0.000 title claims abstract description 86
- 239000002184 metal Substances 0.000 title claims abstract description 86
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 238000011282 treatment Methods 0.000 claims abstract description 52
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 47
- 239000011701 zinc Substances 0.000 claims abstract description 47
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 43
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims abstract description 32
- 229910052749 magnesium Inorganic materials 0.000 claims abstract description 25
- 239000011777 magnesium Substances 0.000 claims abstract description 25
- 206010006458 Bronchitis chronic Diseases 0.000 claims abstract description 6
- 208000005171 Dysmenorrhea Diseases 0.000 claims abstract description 6
- 206010013935 Dysmenorrhoea Diseases 0.000 claims abstract description 6
- 208000019695 Migraine disease Diseases 0.000 claims abstract description 6
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims abstract description 6
- 208000006673 asthma Diseases 0.000 claims abstract description 6
- 206010006451 bronchitis Diseases 0.000 claims abstract description 6
- 208000007451 chronic bronchitis Diseases 0.000 claims abstract description 6
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 6
- 206010022437 insomnia Diseases 0.000 claims abstract description 6
- 206010027599 migraine Diseases 0.000 claims abstract description 6
- 229910052783 alkali metal Inorganic materials 0.000 claims abstract description 5
- 150000001340 alkali metals Chemical class 0.000 claims abstract description 5
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims abstract description 5
- 238000000137 annealing Methods 0.000 claims description 28
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 14
- 229910052710 silicon Inorganic materials 0.000 claims description 14
- 239000010703 silicon Substances 0.000 claims description 14
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 13
- 239000011574 phosphorus Substances 0.000 claims description 13
- 229910052698 phosphorus Inorganic materials 0.000 claims description 13
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical group [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 11
- 229910052744 lithium Inorganic materials 0.000 claims description 11
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 8
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 8
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 8
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 7
- 229910052791 calcium Inorganic materials 0.000 claims description 7
- 239000011575 calcium Substances 0.000 claims description 7
- 229910052742 iron Inorganic materials 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 6
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 claims description 6
- 229910017052 cobalt Inorganic materials 0.000 claims description 6
- 239000010941 cobalt Substances 0.000 claims description 6
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 6
- 229910052802 copper Inorganic materials 0.000 claims description 6
- 239000010949 copper Substances 0.000 claims description 6
- 229910052726 zirconium Inorganic materials 0.000 claims description 6
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 5
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 5
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 5
- 229910052709 silver Inorganic materials 0.000 claims description 5
- 239000004332 silver Substances 0.000 claims description 5
- 229910052719 titanium Inorganic materials 0.000 claims description 5
- 239000010936 titanium Substances 0.000 claims description 5
- 229910052684 Cerium Inorganic materials 0.000 claims description 4
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 4
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims description 4
- 229910052793 cadmium Inorganic materials 0.000 claims description 4
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 claims description 4
- GWXLDORMOJMVQZ-UHFFFAOYSA-N cerium Chemical compound [Ce] GWXLDORMOJMVQZ-UHFFFAOYSA-N 0.000 claims description 4
- 229910052804 chromium Inorganic materials 0.000 claims description 4
- 239000011651 chromium Substances 0.000 claims description 4
- 229910052750 molybdenum Inorganic materials 0.000 claims description 4
- 239000011733 molybdenum Substances 0.000 claims description 4
- 229910052759 nickel Inorganic materials 0.000 claims description 4
- 229910052758 niobium Inorganic materials 0.000 claims description 4
- 239000010955 niobium Substances 0.000 claims description 4
- GUCVJGMIXFAOAE-UHFFFAOYSA-N niobium atom Chemical compound [Nb] GUCVJGMIXFAOAE-UHFFFAOYSA-N 0.000 claims description 4
- 229910052763 palladium Inorganic materials 0.000 claims description 4
- 229910052697 platinum Inorganic materials 0.000 claims description 4
- 229910052712 strontium Inorganic materials 0.000 claims description 4
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims description 4
- 229910052715 tantalum Inorganic materials 0.000 claims description 4
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 13
- 238000006263 metalation reaction Methods 0.000 abstract 1
- 229910045601 alloy Inorganic materials 0.000 description 26
- 239000000956 alloy Substances 0.000 description 26
- 239000002729 catgut Substances 0.000 description 20
- 238000001467 acupuncture Methods 0.000 description 9
- 235000018102 proteins Nutrition 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 230000004580 weight loss Effects 0.000 description 7
- 210000000028 corpus adiposum pararenale Anatomy 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 238000012545 processing Methods 0.000 description 6
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 5
- 210000000988 bone and bone Anatomy 0.000 description 5
- 230000007423 decrease Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000000638 stimulation Effects 0.000 description 4
- 230000003442 weekly effect Effects 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 201000001320 Atherosclerosis Diseases 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- 108010023302 HDL Cholesterol Proteins 0.000 description 2
- 108010028554 LDL Cholesterol Proteins 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 206010048259 Zinc deficiency Diseases 0.000 description 2
- 238000009098 adjuvant therapy Methods 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 210000002889 endothelial cell Anatomy 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 229910000861 Mg alloy Inorganic materials 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
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- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000002805 bone matrix Anatomy 0.000 description 1
- 230000003925 brain function Effects 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 210000004413 cardiac myocyte Anatomy 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 229960004275 glycolic acid Drugs 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 230000003680 myocardial damage Effects 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 230000004007 neuromodulation Effects 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- JAJWGJBVLPIOOH-IZYKLYLVSA-M sodium taurocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 JAJWGJBVLPIOOH-IZYKLYLVSA-M 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000009441 vascular protection Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C23/00—Alloys based on magnesium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
-
- C—CHEMISTRY; METALLURGY
- C21—METALLURGY OF IRON
- C21D—MODIFYING THE PHYSICAL STRUCTURE OF FERROUS METALS; GENERAL DEVICES FOR HEAT TREATMENT OF FERROUS OR NON-FERROUS METALS OR ALLOYS; MAKING METAL MALLEABLE, e.g. BY DECARBURISATION OR TEMPERING
- C21D9/00—Heat treatment, e.g. annealing, hardening, quenching or tempering, adapted for particular articles; Furnaces therefor
- C21D9/52—Heat treatment, e.g. annealing, hardening, quenching or tempering, adapted for particular articles; Furnaces therefor for wires; for strips ; for rods of unlimited length
- C21D9/525—Heat treatment, e.g. annealing, hardening, quenching or tempering, adapted for particular articles; Furnaces therefor for wires; for strips ; for rods of unlimited length for wire, for rods
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C18/00—Alloys based on zinc
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22F—CHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
- C22F1/00—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
- C22F1/06—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of magnesium or alloys based thereon
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22F—CHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
- C22F1/00—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
- C22F1/16—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of other metals or alloys based thereon
- C22F1/165—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of other metals or alloys based thereon of zinc or cadmium or alloys based thereon
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Mechanical Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Veterinary Medicine (AREA)
- Rehabilitation Therapy (AREA)
- Surgery (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Finger-Pressure Massage (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention discloses a kind of metal and sunkens cord, and a kind of metal is sunken cord, and counts according to weight percent 100%, described sunken cord is made of metal M and element X, wherein 90%≤metal M≤100%, remaining is element X；The M be at least one of magnesium or zinc, the X be nonmetalloid, main group alkali metal element, main group alkali earth metal,At least one of race's element, B metal element；Meanwhile the preparation method and its purposes being used to prepare in slimming apparatus sunken cord the invention also discloses the metal and preparation can assist in the treatment of the purposes of the instrument of sunkening cord of chronic bronchitis, asthma, insomnia, dysmenorrhea, migraine or diabetes.Metal provided by the invention is sunken cord, and when being used for weight reducing treatments, effect is obvious, and effective duration is long, is able to maintain 6 months and does not rebound after sunkening cord 1 time.
Description
Technical field
The invention belongs to traditional Chinese medicine the field of medical instrument technology, and in particular to a kind of metal is sunken cord and preparation method thereof and answered
With.
Background technique
Its principle of Chinese medicine acupuncture is exactly the stimulation that applies acupuncture to human acupoint, though Chinese medicine acupuncture weight-reducing or clinical treatment have one
Determine therapeutic effect, but since the time of stimulation is short, needle, which burns, after starting disappears, and daily or wound of treat every other day is small, without bad
Reaction, not long lasting for stimulation, the effect is relatively poor.
Weight-reducing of sunkening cord is the extension and development of Acupancture, is the outer moxibustion of Improvement type.The medical effect of weight-reducing of sunkening cord is Chinese medicine
Acupuncture moxibustion mechanism is stimulated by the acupuncture point to human body, can play the role of weight reducing treatments.It sunkens cord currently on the market the material of weight-reducing
Material develops to polycarboxylic acids hydroxyacetic acid PLGA(medical collagen by traditional catgut), PLGA is a kind of high molecular polymerization
Object, physical stimulation tissue reaction is extremely low, and treatment in each to two weeks is primary, and wound is small when sunkening cord, and has no adverse reaction.But mesh
Before the sunken cord major defect of weight-reducing be effectively to hold time short, be easy rebound, it is also necessary to repeatedly sunken cord, next these materials and people
Body has some undesirable reactions.
Magnesium, zinc are that the essential trace elements of the human body, magnesium and magnesium alloy have tempting application prospect as biomaterial, and
Zinc and kirsite are then the hot spots of biodegradable material research in recent years, though zinc is microelement, effect in human body
Non- big, have the title of " spark of life plug ": (1) zinc is related with various bone matrix synzyme, it can participate in bon e formation and bone
It rebuilds, when zinc deficiency, the activity decline of a variety of zinc enzymes, the growth of bone are suppressed in bone；(2) zinc is the key that biomembrane
Component part plays a significant role in the structure and function for maintaining more than 2000 kinds of transcription factors and more than 300 kinds of enzymes；(3) zinc
Endothelial cell can be quickly entered, the integrality of endothelial cell is maintained, reduces blood vessel to the neurological susceptibility of atherosclerosis；(4)
Zinc can protect cardiac muscle cell avoid Acute oxidative stress and myocardial damage caused by inflammatory reaction；(5) zinc can actively join
Synthesize with nucleic acid-protein, acceleration of wound healing: (6) furthermore zinc is also closely related with various cell metabolisms effect in vivo, such as sugared generation
It thanks, lipid metabolism and anti-ageing etc..Zinc deficiency will lead to artery sclerosis, arrhythmia cordis and failure, brain function deformity, immunity it is low
Under, diarrhea, loss of appetite, growth slow down, the decline of hair loss, yctalopia, hypertrophy of the prostate, male reproductive function, anaemia etc..It is adult every
15-25mg zinc is supplemented day by day.Magnesium, zinc and its alloy are a kind of and the good material of human-body biological compatibility, can be fabricated to orthopaedics
It is placed in device: bone plate, bone nail etc..Since it is implanted into after human body through that can decompose in human body after a period of time, inhaled by human body
It receives or drains.The pain and burden of patient can be reduced by taking out device without second operation.
Summary of the invention
In view of the drawbacks of the prior art, the present invention provides a kind of metal and sunkens cord and preparation method thereof, and described sunken cord is being used for
When weight-reducing, length of effectively holding time, and be not easy to rebound.
A kind of metal is sunken cord, and is counted according to weight percent 100%, and described sunken cord is made of metal M and element X, wherein
90%≤metal M≤100%, remaining is element X；The M is at least one of magnesium or zinc, and the X is nonmetalloid, main group
Alkali metal element, main group alkali earth metal,At least one of race's element, B metal element.
Preferably, the nonmetalloid is at least one of silicon, phosphorus；The main group alkali metal element is lithium；It is described
Main group alkali earth metal is at least one of calcium, strontium.
Preferably, describedRace's element is at least one of iron, cobalt, nickel, palladium, platinum.
Preferably, the B metal element is titanium, manganese, copper, zirconium, niobium, molybdenum, silver, cadmium, tantalum, chromium, at least one in cerium
Kind.
Preferably, 95%≤metal M≤100%.
Preferably, 98%≤metal M≤100%.
The preparation method that above-mentioned metal is sunken cord, the method are as follows: after metal M and element X-alloy, it is squeezed into bar,
Then the drawing and annealing for passing through multi-pass are drawn to the filament that diameter is 0.03-0.2mm.
Above-mentioned metal is sunken cord the purposes being used to prepare in slimming apparatus.
Preferably, the slimming apparatus is instrument of sunkening cord；It is highly preferred that the slimming apparatus is cord-embedding needle.
Above-mentioned metal sunken cord be used to prepare can assist in the treatment of chronic bronchitis, asthma, insomnia, dysmenorrhea, migraine or
The purposes of the instrument of sunkening cord of diabetes；It is furthermore preferred that the instrument of sunkening cord is cord-embedding needle.
At least one of the present invention, when its content is two or more, ratio is arbitrary.
It is of the present invention by metal M and element X-alloy, i.e., using the prior art by metal M and element X-alloy；Institute
Extruding, drawing and annealing are stated, is the prior art.
Cord-embedding needle of the present invention is cord-embedding needle in the prior art, and the cord-embedding needle includes that metal of the present invention buries
Line；For when losing weight, i.e., using method of weight-reducing of sunkening cord in the prior art, sunkening cord to related acupuncture point.
Instrument sunken cord when being used to assist in the treatment of chronic bronchitis, asthma, insomnia, dysmenorrhea, migraine or diabetes,
Embedding method in the prior art is used, is sunken cord to related acupuncture point.
Advantages of the present invention:
Metal provided by the invention is sunken cord, and when being used for weight reducing treatments, effect is obvious, and effective duration is long, energy after sunkening cord 1 time
It keeps not rebounding for 6 months, effect is substantially better than protein line in the prior art and sunkens cord；In addition, metal of the present invention is sunken cord, also
It can be used for the adjuvant treatment of chronic bronchitis, asthma, insomnia, dysmenorrhea, migraine or diabetes etc..
Detailed description of the invention
Fig. 1 perirenal fat content；
The analysis of Fig. 2 four items of blood lipid tests；
The weight loss percentage of Fig. 3 treatment group 24W.
Specific embodiment
Embodiment 1
A kind of metal is sunken cord, and is made of 100% Mg；Using the prior art, magnesium metal is squeezed into bar, then passes through multiple tracks
Secondary drawing and annealing is drawn to the filament that diameter is 0.03-0.2mm.
Embodiment 2
A kind of metal is sunken cord, and is made of 100% Zn；Using the prior art, metallic zinc is squeezed into bar, then passes through multiple tracks
Secondary drawing and annealing is drawn to the filament that diameter is 0.03-0.2mm.
Embodiment 3
A kind of metal is sunken cord, and is made of Zn and Mg；Using the prior art, metallic zinc and magnesium are squeezed into bar, then through excessive
The drawing and annealing of passage are drawn to the filament that diameter is 0.03-0.2mm.
Embodiment 4
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of the X of 90% magnesium, 10%, the X be nonmetalloid silicon and
Phosphorus；Bar is squeezed into after magnesium metal, element X-alloy using the prior art, then passes through the drawing and annealing of multi-pass
Processing is drawn to the filament that diameter is 0.03-0.2mm.
Embodiment 5
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of the X of 95% magnesium, 5%, the X be nonmetalloid silicon and
Phosphorus；Bar is squeezed into after magnesium metal, element X-alloy using the prior art, then passes through the drawing and annealing of multi-pass
Processing is drawn to the filament that diameter is 0.03-0.2mm.
Embodiment 6
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of the X of 98% magnesium, 2%, the X be nonmetalloid silicon and
Phosphorus；Bar is squeezed into after magnesium metal, element X-alloy using the prior art, then passes through the drawing and annealing of multi-pass
Processing is drawn to the filament that diameter is 0.03-0.2mm.
Embodiment 7
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of the X of 95% magnesium, 5%, and the X is lithium；Using the prior art,
After magnesium metal, element X-alloy, it is squeezed into bar, then passes through the drawing and annealing of multi-pass, being drawn to diameter is
The filament of 0.03-0.2mm.
Embodiment 8
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of the X of 98% magnesium, 2%, and the X is calcium and strontium；Using existing
Technology is squeezed into bar after magnesium metal, element X-alloy, then passes through the drawing and annealing of multi-pass, is drawn to
Diameter is the filament of 0.03-0.2mm.
Embodiment 9
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of the X of 92% magnesium, 8%, and the X is iron, cobalt, nickel, palladium and platinum；
Bar is squeezed into after magnesium metal, element X-alloy using the prior art, is then passed through at the drawing and annealing of multi-pass
Reason is drawn to the filament that diameter is 0.03-0.2mm.
Embodiment 10
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of the X of 95% magnesium, 5%, the X be titanium, manganese, copper, zirconium, niobium,
Molybdenum, silver, cadmium, tantalum, chromium and cerium；Bar is squeezed into after magnesium metal, element X-alloy using the prior art, then through excessive
The drawing and annealing of passage are drawn to the filament that diameter is 0.03-0.2mm.
Embodiment 11
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of the X of 98% magnesium, 2%, the X be silicon, lithium, calcium, iron, cobalt,
Titanium, manganese, copper, zirconium；Bar is squeezed into after magnesium metal, element X-alloy using the prior art, then passes through the drawing of multi-pass
It pulls out and makes annealing treatment, be drawn to the filament that diameter is 0.03-0.2mm.
Embodiment 12
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of the X of 90% zinc, 10%, the X be nonmetalloid silicon and
Phosphorus；Bar is squeezed into after metallic zinc, element X-alloy using the prior art, then passes through the drawing and annealing of multi-pass
Processing is drawn to the filament that diameter is 0.03-0.2mm.
Embodiment 13
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of the X of 95% zinc, 5%, the X be nonmetalloid silicon and
Phosphorus；Bar is squeezed into after metallic zinc, element X-alloy using the prior art, then passes through the drawing and annealing of multi-pass
Processing is drawn to the filament that diameter is 0.03-0.2mm.
Embodiment 14
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of the X of 98% zinc, 2%, the X be nonmetalloid silicon and
Phosphorus；Bar is squeezed into after metallic zinc, element X-alloy using the prior art, then passes through the drawing and annealing of multi-pass
Processing is drawn to the filament that diameter is 0.03-0.2mm.
Embodiment 15
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of the X of 95% zinc, 5%, and the X is lithium；Using the prior art,
After metallic zinc, element X-alloy, it is squeezed into bar, then passes through the drawing and annealing of multi-pass, being drawn to diameter is
The filament of 0.03-0.2mm.
Embodiment 16
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of 90% metal M, 10% X, and the M is magnesium and zinc, the X
For silicon and phosphorus；Bar is squeezed into after metal Mg, Zn, element X-alloy using the prior art, then passes through the drawing of multi-pass
It pulls out and makes annealing treatment, be drawn to the filament that diameter is 0.03-0.2mm.
Embodiment 17
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of 98% metal M, 2% X, and the M is magnesium and zinc, the X
For lithium；Bar is squeezed into after metal Mg, Zn, element X-alloy using the prior art, then by multi-pass drawing and
Annealing is drawn to the filament that diameter is 0.03-0.2mm.
Embodiment 18
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of the X of 98% zinc, 2%, and the X is calcium and strontium；Using existing
Technology is squeezed into bar after metallic zinc, element X-alloy, then passes through the drawing and annealing of multi-pass, is drawn to
Diameter is the filament of 0.03-0.2mm.
Embodiment 19
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of the X of 98% zinc, 2%, and the X is iron, cobalt, nickel, palladium, platinum；
Bar is squeezed into after metallic zinc, element X-alloy using the prior art, is then passed through at the drawing and annealing of multi-pass
Reason is drawn to the filament that diameter is 0.03-0.2mm.
Embodiment 20
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of the X of 98% zinc, 2%, the X be titanium, manganese, copper, zirconium, niobium,
Molybdenum, silver, cadmium, tantalum, chromium, cerium；Bar is squeezed into after metallic zinc, element X-alloy using the prior art, then passes through multiple tracks
Secondary drawing and annealing is drawn to the filament that diameter is 0.03-0.2mm.
Embodiment 21
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of the X of 98% zinc, 2%, and the X is phosphorus, lithium, calcium, iron；Using
The prior art is squeezed into bar after metallic zinc, element X-alloy, then passes through the drawing and annealing of multi-pass, draws
Pull out the filament for being 0.03-0.2mm to diameter.
Embodiment 22
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of the X of 98% zinc, 2%, the X be silicon, lithium, calcium, iron, cobalt,
Copper, zirconium, silver；Bar is squeezed into after metallic zinc, element X-alloy using the prior art, then passes through the drawing of multi-pass
And annealing, it is drawn to the filament that diameter is 0.03-0.2mm.
Embodiment 23
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of the X of 98% magnesium, 2%, and the X is silicon, phosphorus, lithium；Using existing
There is technology, after magnesium metal, element X-alloy, be squeezed into bar, then passes through the drawing and annealing of multi-pass, drawing
The filament for being 0.03-0.2mm to diameter.
Embodiment 24
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of the X of 98% zinc, 2%, and the X is silicon, phosphorus, lithium；Using existing
There is technology, after metallic zinc, element X-alloy, be squeezed into bar, then passes through the drawing and annealing of multi-pass, drawing
The filament for being 0.03-0.2mm to diameter.
Embodiment 25
A kind of metal is sunken cord, and is counted according to weight ratio 100%, is made of 98% metal M, 2% X, and the M is zinc and magnesium, the X
For silicon, phosphorus, lithium；Bar is squeezed into after magnesium metal, zinc, element X-alloy using the prior art, then by multi-pass
Drawing and annealing are drawn to the filament that diameter is 0.03-0.2mm.
One, weight-reducing application
(1) weight-reducing test effect of the invention
2 months big small white mouses are chosen, every group 10, there was no significant difference for the weight between small white mouse, the body between small white mouse
There was no significant difference for weight, feeds high-sugar-fat-diet, and after two months, the average weight of small white mouse both increases 35g or more for feeding,
Modeling success；Then catgut embedding for treatment is carried out, sunkens cord and sunkens cord to be provided in an embodiment of the present invention, using the side of sunkening cord in the prior art
Method sunken cord 1 time to 5 acupuncture points of small white mouse, and small white mouse normally feeds during treatment, in 8 weeks for the treatment of, small white mouse
Average weight variation is shown in Table 1；
The high-sugar-fat-diet that model group is fed in the present invention is following (in percentage by weight): 51.8% maintenance basestocks,
20% lard, 3% sesame oil, 10% sucrose, 10% casein, 2% experimental animal premix, 2% calcium monohydrogen phosphate, 1% cholesterol, 0.2%
Sodium taurocholate；
The changes of weight of 1 small white mouse of table
As shown in Table 1, metal provided by the invention is sunken cord, and has certain mitigation to the weight of small white mouse within 8 weeks.
(2) compared to the prior art fat-reducing effect of the invention
2 months big small white mouses are chosen, every group of 10 small white mouses, there was no significant difference for the weight between small white mouse, is denoted as respectively
Blank group, model group, catgut group, protein line group (PLGA), metal are sunken cord group (embodiment 24), catgut group, protein line group,
Metal group of sunkening cord is denoted as treatment group, and blank group feeds normal diet, model group and treatment group's feeding high-sugar-fat-diet (ibid),
After two months, the average weight of blank group big white mouse is 415g for feeding, and the average weight of model group and treatment group is all on the left side 458g
The right side, modeling success；Then catgut embedding for treatment is started to the small white mouse for the treatment of group, using embedding method in the prior art to small white mouse
5 acupuncture points sunken cord, without catgut embedding for treatment, all small white mouses are normally fed for blank group and model group.
1. the changes of weight for the treatment of 8 weeks is shown in Table 2；
2 small white mouse of table is in 8 weeks body weights of catgut embedding for treatment (unit: g)
Wherein, catgut group be weekly carry out catgut embedding for treatment 1 time, continuous 4 weeks be 1 course for the treatment of, 2 courses for the treatment of of co-continuous treatment, i.e.,
Carried out 1 catgut embedding for treatment weekly at first 8 weeks；Protein line group is primary in treatment in the 1st week, the 8 Monday courses for the treatment of；Metal sunkens cord group
It treats 1 time within 1 week；
As shown in Table 2, the weight of blank group and model group persistently increases within 8 weeks；In the present embodiment, catgut group weight is held
Continuous to reduce, at the 5W(weeks) when weight bottom out；It treats 1 time within protein line group every 8 weeks, is 1 course for the treatment of, the present embodiment egg
White line group was treated 1 time at the 1st week, and the weight bottom out from the 7th week also needs to adhere to 1 course for the treatment of in successive treatment；And metal
It sunkens cord group treatment 1 time, continued weight reduces within 8 weeks；After treating 8 weeks, the weight 465g of blank group, the average weight of model group
For 499g, metal is sunken cord the weight 384g of group, is reduced by 17% than blank group, is reduced by 23% than model group.
2. perirenal fat content analysis is shown in Fig. 1 after catgut embedding for treatment 8 weeks；
As shown in Figure 1, blank group perirenal fat amount is minimum, model group highest, shows modeling success；Catgut group is treated through 4 times
Perirenal fat amount reduces most significant afterwards；Protein line group perirenal fat amount is highest in treatment group, and with model group without statistics
Difference；Metal sunkens cord group perirenal fat amount lower than protein line group, has statistical difference with model group.
3. Fig. 2 is shown in four items of blood lipid tests analysis after catgut embedding for treatment 8 weeks；
As shown in Figure 2, in treatment group, metal group TCHO and LDL-C content of sunkening cord is minimum, i.e. atherosclerosis coronary heart disease
Risk is minimum；And HDL-C and LDL-C trend on the contrary, HDL-C metal is sunken cord a group highest, i.e., vascular protection is acted on it is most strong, in blood
Rouge regulation aspect has a clear superiority, and has to body neuromodulation and remarkably promotes effect.Zinc and magnesium are all needed by human micro-
Secondary element, they are fine with the biocompatibility of human body, and magnesium and zinc have become the hot spot that biomaterial is studied, and have been used for drop
Solve the material of intravascular stent and orthopaedics merging.For being careful in one's diet, doing more physical exercises if can be aided with when losing weight, lose weight for a long time
Have better effect.
4. the changes of weight for the treatment of 24 weeks is shown in Fig. 3；
In addition, catgut group be weekly carry out catgut embedding for treatment 1 time, continuous 4 weeks be 1 course for the treatment of, 2 courses for the treatment of of co-continuous treatment, i.e.,
Carried out 1 catgut embedding for treatment weekly at first 8 weeks；Protein line group is primary in treatment in the 1st week, the 8 Monday courses for the treatment of, in the 9th week Shi Jinhang
2nd catgut embedding for treatment；Metal sunkens cord group in treatment in the 1st week 1 time；I.e. in 24 weeks for the treatment of, catgut group is treated 8 times, albumen
Line group is treated 2 times；Metal is sunken cord group treatment 1 time;
From the figure 3, it may be seen that catgut group, starts after the 4th week, weight loss percentage rises, and illustrates that weight starts to rebound, but
After the 8th week, weight loss percentage is begun to decline again, until 16 weeks later begin to ramp up, at 24 weeks, almost approach with
Weight before weight reducing treatments；Protein line group, weight loss percentage is risen after the 6th week, but is had out after the 8th week
Begin to decline, until the 16th week begins to ramp up later, at 24 weeks, weight loss percentage had been added to -2.30%, had connect
Closely with the weight before weight-reducing, after treatment 2 times, fat-reducing effect can maintain 18-20 week substantially, after 20 weeks it is quick anti-
Bullet；Metal is sunken cord group, although relatively slow at more other two groups of preceding 4 weeks weight loss, weight can maintain substantially after 8 weeks
One relatively stable state, at the 8th week to the 24th week, weight loss percentage rose to -14.44% from -15.9%, rose
Very little, illustrates that fertile lasting effect is long, can maintain body mass stable substantially in the later period.
Two, metal provided by the invention is sunken cord, adjuvant treatment diabetes, chronic bronchitis, asthma, insomnia, dysmenorrhea,
The diseases such as migraine equally have preferable effect.
Claims (10)
1. a kind of metal is sunken cord, it is characterised in that: it is counted according to weight percent 100%, it is described to sunken cord by metal M and element X group
At, wherein 90%≤metal M≤100%, remaining is element X；The M is at least one of magnesium or zinc, and the X is nonmetallic
Element, main group alkali metal element, main group alkali earth metal,At least one of race's element, B metal element.
2. metal is sunken cord according to claim 1, it is characterised in that: the nonmetalloid is at least one of silicon, phosphorus；
The main group alkali metal element is lithium；The main group alkali earth metal is at least one of calcium, strontium.
3. metal is sunken cord according to claim 1, it is characterised in that: describedRace's element is iron, in cobalt, nickel, palladium, platinum
It is at least one.
4. metal is sunken cord according to claim 1, it is characterised in that: the B metal element be titanium, manganese, copper, zirconium, niobium,
At least one of molybdenum, silver, cadmium, tantalum, chromium, cerium.
5. metal is sunken cord according to claim 1, it is characterised in that: 95%≤metal M≤100%.
6. metal is sunken cord according to claim 5, it is characterised in that: 98%≤metal M≤100%.
7. the preparation method that metal described in claim 1 is sunken cord, it is characterised in that: the method are as follows: close metal M and element X
After aurification, it is squeezed into bar, then passes through the drawing and annealing of multi-pass, being drawn to diameter is the thin of 0.03-0.2mm
Silk.
The purposes being used to prepare in slimming apparatus 8. any one of the claim 1-6 metal is sunken cord.
9. purposes according to claim 8, it is characterised in that: the slimming apparatus is instrument of sunkening cord.
10. any one of the claim 1-6 metal sunken cord be used to prepare can assist in the treatment of chronic bronchitis, asthma, insomnia,
The purposes of the instrument of sunkening cord of dysmenorrhea, migraine or diabetes.
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| CN113564422A (en) * | 2021-08-03 | 2021-10-29 | 太原理工大学 | Biodegradable zinc-niobium alloy and preparation method thereof |
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