CN104511055A - Application of degradable metallic material in preparation of implant for acupoint embedding - Google Patents
Application of degradable metallic material in preparation of implant for acupoint embedding Download PDFInfo
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- CN104511055A CN104511055A CN201310451068.7A CN201310451068A CN104511055A CN 104511055 A CN104511055 A CN 104511055A CN 201310451068 A CN201310451068 A CN 201310451068A CN 104511055 A CN104511055 A CN 104511055A
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Abstract
The invention provides application of a degradable metallic material in preparation of an implant for acupoint embedding. The degradable metallic material is a magnesium based metal material. According to the invention, a biodegradable magnesium based metal material is applied to replace traditional catgut to conduct acupoint embedding treatment, and has the characteristics of stable absorption, complete degradation, trace element release, local antibacterial property, and little tissue reaction. The stimulation intensity and material absorption time can be controlled according to clinical differential treatment needs, and the treatment effect of acupoint embedding can be brought into full play and expanded.
Description
Technical field
The present invention relates to a kind of application of biodegradable metal material, particularly relate to a kind of degradable metal material for the preparation of the application in the implant of acupoint burying.
Background technology
Catgut implantation at acupoint is development and the extension of traditional acupuncture Therapeutic Method, its theoretical basis imbeds in specific acupuncture point by needle set or medicated line, thus a kind of slow, soft, lasting and optimum pin sense effect is produced to acupuncture point, the long-term work playing dredging the meridian treats effect that is chronic, stubborn disease in order to reach.The degradable stitching thread of the current mainly operation stitching catgut embedding for acupuncture point and various chemosynthesis.
Such as CN1631454A discloses a kind of medicated line for acupoint thread-embedding therapy, described medicated line is the medical catgut of medical alcohol liquid immersion treatment through comprising Rhizoma Coptidis, Radix Scutellariae, HUANGBAI(sic), Radix Et Rhizoma Rhei, medicated line acupoint burying, acupuncture point is reactive strong, stimulation time is long, persistent, adds that chronic drug acupuncture point discharges, and strengthens the therapeutical effect of meridian point; And " four is yellow " medicine heat-clearing and toxic substances removing, antiinflammatory pathogenic fire purging, can alleviate rejection.And for example CN1183971A discloses a kind of medicinal catgut, adopts medical catgut, Radix Angelicae Sinensis, Flos Carthami and soak by water, naturally dries Hou, adopts the medicamental pulverata of Moschus, sulfur, Rhizoma Atractylodis to fumigate and obtains.But the main component of catgut is bioprotein, is degraded in vivo by the effect of bio protease.Due to Different Individual, different parts, there is larger difference in the secretory volume of proteasome, effective support and the degradation time of inserting human body are difficult to control, and can not need to control stimulus intensity and action time according to clinical treatment.Therefore, although catgut obtains convenient, low price, hamper its extensive use in acupuncture point is embedding due to above defect.
CN1748802A discloses the application of a kind of degradable material suture in acupoint burying, line body material therefor is the Polymer Synthesizing material surgical stitching thread such as polyglycolic acid, Acetic acid, hydroxy-, bimol. cyclic ester and lactide copolymer, dioxocyclohex ketone polymer, glycomer, the stitching thread of application degradable synthetic material replaces traditional catgut to carry out acupoint burying treatment, there is tissue reaction minimum, Vapor recovery unit, can need to control stimulus intensity and line body soak time according to clinical syndrome differentiation treatment, line body absorbs the advantage such as completely.Although degradable stitching thread belongs to Polymer Synthesizing medical material, in vivo by the work of acidify or alkalization in order to complete degraded, its degradation time has obvious prolongation compared with catgut, be convenient to embedding for a long time, continue to play therapeutical effect, but foreign body due to material, happen occasionally after implanting local inflammatory response, sunken cord and absorb not exclusively, even non-absorbent phenomenon.
Therefore, be necessary to improve embedding line body and material, to meet the needs of clinical treatment.
Summary of the invention
The object of the invention is to overcome above-mentioned deficiency, provide a kind of degradable metal material for the preparation of the new application in the implant of acupoint burying, to meet the needs of clinical treatment.
The invention provides a kind of degradable metal material for the preparation of the application in the implant of acupoint burying.
Preferably, described degradable metal material is magnesium-base metal material.
Preferably, in described magnesium-base metal material, the content of magnesium elements is 90-100wt%, is more preferably >=92wt%, is more preferably >=94wt%, is more preferably >=96wt%, is more preferably >=97wt%, is more preferably 98-100wt%.
According to disease character and treatment needs, described magnesium-base metal material can select pure magnesium or the magnesium base alloy with other element combinations.
In described magnesium base alloy except magnesium elements, can also contain in copper, zinc, manganese, selenium, strontium, calcium, ferrum, zirconium, stannum, nickel, aluminum, silver etc. one or more, and/or one or more in rare earth metal.
Described rare earth metal comprises scandium, yttrium, lanthanum, cerium, praseodymium, neodymium, hard iron, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutecium.
Preferably, the area load of described implant has medicine and/or the beneficial growth factor.Described medicine and the beneficial growth factor need to select according to disease character and treatment.
Preferably, the surface-coated of described implant has biodegradable coating, can alleviate the degradation speed of implant.
Wherein, described biodegradable coating is degradable macromolecule coating and/or degradable ceramic coating.
Further preferably, described biodegradable coating load has medicine and/or the beneficial growth factor.
The composition material of degradable macromolecule coating is preferably Poly(D,L-lactide-co-glycolide (PLGA), polyglycolic acid (PGA), polylactic acid (PLA), PLLA (PLLA), polycaprolactone (PCL), poly-hydroxy acrylate (PACA), gathers one or more in dioxane ketone, condensing model, poly phosphazene, polymer-amino-acid, poly-B-butyric ester and hydroxypentanoic acid fat and copolymer etc. thereof.
The composition material of degradable ceramic coating is preferably one or more of hydroxyapatite, strontium containing hydroxyapatite, Silicon-Substituted Hydroxyapatite, B-trialcium phosphate and phosphoric acid oxygen four calcium.
Wherein, described implant is prepared into various shape and size as required, and such as its shape can adopt but be not limited to wire, bar-shaped or block etc.
The thickness of biodegradable coating is preferably 0.01-5mm, is more preferably 0.05-3mm, is more preferably 0.1-2mm, such as 0.5mm, 1mm, 1.5mm or 2mm.
Preferably, described implant is wire or bar-shaped.
Further preferably, the length of described implant is 0.1-20cm, is more preferably 0.1-15cm, is more preferably 0.5-10cm, be more preferably 0.5-5cm, such as 4cm, 5cm or 4.5cm.
The present invention has the following advantages:
(1) material surface can carry out layer or mix other elements making alloy, effectively can control material degradation time in vivo;
(2) magnesium-base metal material is elementary composition according to difference, at heeling-in position release of trace elements, can improve microenvironment by trace element.During magnesium alloy degraded, local meta-alkalescence, stimulates further to acupuncture point.
(3) material surface can carry out spraying, medicine carrying, there is the effect of " Treated By Combined Therapy of Acupuncture And Drug ";
(4) magnesium-base metal material has good biocompatibility and biological activity, and the organ rejection episodes after implanting is little, discharges after the element such as calcium, magnesium is absorbed and used and have raising immunity after degraded, promotes the effect such as tissue growth, reparation;
(5) magnesium-base metal material has certain antibacterial action, can avoid the infection treating position after implantation.
The catgut that the present invention applies biodegradable magnesium-base metal material substitution traditional carries out acupoint burying treatment, there is Vapor recovery unit, can be degradable, release of trace elements, can local antibacterial, tissue reaction is little, can need to control stimulus intensity and absorbed time according to clinical syndrome differentiation treatment, can give full play to and expand the therapeutic effect of acupoint burying.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, to understand the present invention better.
Embodiment 1
Prepare the pure magnesium silk thread that diameter is 0.5mm.
Biological safety: carry out biological assessment according to experimental technique described in GB/T16886.Experimental result shows, pure magnesium silk thread does not have obvious cytotoxicity and hemagglutinin to fibroblast, does not have obvious sensitization, stimulation and genetoxic.
Rat is sunken cord experiment: the SD rat of point catgut-embedding therapy for treating Splenic asthenia and obstruction of dampness obesity, acupoint selection: Quchi, rich and prosperous, the cave such as Guan Yuan, tsu san li, sp 9.Pure magnesium silk thread is cut out the line body into 2cm, oxirane disinfection, with reference to rat meridional point collection of illustrative plates, utilize at above-mentioned acupuncture point place imbedding tool to implant subcutaneous by line body.This line body degradation time is about 4 weeks, can repeat once at 4 weeks, and after three courses for the treatment of, rat edema, body weight alleviate all to some extent.
Embodiment 2
Prepare the Mg-Zn silk thread that diameter is 0.4mm, in described Mg-Zn silk thread, the content of Zn is 2.3wt%, and surplus is Mg.
Biological safety: carry out biological assessment according to experimental technique described in GB/T16886.Experimental result shows, the Mg-Zn silk thread being coated with PLGA coating does not have obvious cytotoxicity and hemagglutinin to fibroblast, does not have obvious sensitization, stimulation and genetoxic.
Rat is sunken cord experiment: the SD rat of point catgut-embedding therapy for treating type 2 diabetes mellitus, selects cave: Pishu, ke shu, pancreas Yu, tsu san li, sp 6, sp 9.Material is cut out the line body into 0.5cm, oxirane disinfection, with reference to rat meridional point collection of illustrative plates, utilize at above-mentioned acupuncture point place imbedding tool to implant subcutaneous by line body.This line body degradation time is about 4 weeks, can repeat once at 4 weeks, and after three courses for the treatment of, rat blood sugar, body weight obviously alleviate.
Embodiment 3
Preparing diameter is 0.5mmMg-Sr silk thread, and in described Mg-Sr silk thread, the content of Sr is 0.8wt% surplus is Mg.Silk thread is cut out the line body into 2cm, oxirane disinfection, for subsequent use.
The SD rat of point catgut-embedding therapy for treating cold-dampness numbness type osteoarthritis, select cave: in committee, gb 34, neix, outer Xiyan, the sea of blood, yao yang kuan, tsu san li.With reference to rat meridional point collection of illustrative plates, imbedding tool is utilized to implant subcutaneous by line body at above-mentioned acupuncture point place, 4 courses for the treatment of Monday.After three courses for the treatment of, the place's swelling of rat diseased joints alleviates, and range of motion makes moderate progress.
Embodiment 4
Preparing diameter is 0.5mmMg-Ca silk thread, and in described Mg-Ca silk thread, the content of Ca is 1.2wt% surplus is Mg.Silk thread is cut out the line body into 3cm, oxirane disinfection, for subsequent use.
The SD rat of point catgut-embedding therapy for treating cold-dampness numbness type osteoarthritis, select cave: in committee, gb 34, neix, outer Xiyan, the sea of blood, yao yang kuan, tsu san li.With reference to rat meridional point collection of illustrative plates, imbedding tool is utilized to implant subcutaneous by line body at above-mentioned acupuncture point place, 4 courses for the treatment of Monday.After three courses for the treatment of, the place's swelling of rat diseased joints alleviates, and range of motion makes moderate progress.
According to the method described in embodiment 1-4, the magnesium base alloy of the magnesium element content >=90wt% beyond embodiment 2-4 is adopted to prepare implant, carry out biological safety to detect and rat is sunken cord experiment, result all shows that magnesium base alloy does not have obvious cytotoxicity and hemagglutinin to fibroblast, there is no obvious sensitization, stimulation and genetoxic, and the place's swelling of rat diseased joints alleviates, range of motion makes moderate progress.Wherein, other elements in magnesium base alloy be copper, zinc, manganese, selenium, strontium, calcium, ferrum, zirconium, stannum, nickel, aluminum, etc. in one or more, and/or one or more in rare earth metal.
Be described in detail specific embodiments of the invention above, but it is just as example, the present invention is not restricted to specific embodiment described above.To those skilled in the art, any equivalent modifications that the present invention is carried out and substituting also all among category of the present invention.Therefore, equalization conversion done without departing from the spirit and scope of the invention and amendment, all should contain within the scope of the invention.
Claims (11)
1. a degradable metal material is for the preparation of the application in the implant of acupoint burying.
2. application according to claim 1, is characterized in that, described degradable metal material is magnesium-base metal material, comprises pure magnesium or magnesium base alloy.
3. application according to claim 2, is characterized in that, in described magnesium-base metal material, the content of magnesium elements is >=90wt%.
4. application according to claim 1, is characterized in that, the area load of described implant has medicine and/or the beneficial growth factor.
5. application according to claim 1, is characterized in that, the surface of described implant is provided with biodegradable coating.
6. application according to claim 5, is characterized in that, described biodegradable coating is degradable macromolecule coating and/or degradable ceramic coating.
7. application according to claim 6, it is characterized in that, the composition material of described degraded macromolecular coating is Poly(D,L-lactide-co-glycolide, polyglycolic acid, polylactic acid, PLLA, polycaprolactone, poly-hydroxy acrylate, poly-to one or more in dioxane ketone, condensing model, poly phosphazene, polymer-amino-acid, poly-B-butyric ester and hydroxypentanoic acid fat and copolymer thereof.
8. according to the application in claim 1-7 described in any one, it is characterized in that, described implant is wire, bar-shaped and block.
9. application according to claim 8, is characterized in that, described implant is wire or bar-shaped, and length is 0.1-20cm.
10. application according to claim 9, is characterized in that, the length of described implant is 0.5-10cm.
11. application according to claim 10, is characterized in that, the length of described implant is 0.5-5cm.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310451068.7A CN104511055A (en) | 2013-09-27 | 2013-09-27 | Application of degradable metallic material in preparation of implant for acupoint embedding |
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| CN201310451068.7A CN104511055A (en) | 2013-09-27 | 2013-09-27 | Application of degradable metallic material in preparation of implant for acupoint embedding |
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| CN104511055A true CN104511055A (en) | 2015-04-15 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106310372A (en) * | 2015-06-23 | 2017-01-11 | 上海交通大学 | Degradable magnesium-based bone implant drug-loaded high molecular/calcium-phosphorus composite coating and preparation method |
| CN108543231A (en) * | 2018-05-22 | 2018-09-18 | 北京大学口腔医学院 | A kind of degradable multispectral luminous implantation material |
| CN112672698A (en) * | 2018-09-17 | 2021-04-16 | 实验室和人们有限公司 | Thread for catgut embedding therapy and needle tool comprising same for catgut embedding therapy |
| CN115804872A (en) * | 2022-11-29 | 2023-03-17 | 上海交通大学 | Application of degradable magnesium-based metal wire in preparation of fat dissolving material |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2371974Y (en) * | 1999-05-25 | 2000-04-05 | 王维庭 | Acupuncture medicated needle |
| CN1274574A (en) * | 1999-05-25 | 2000-11-29 | 王维庭 | Medicated acupuncture needle and its making process |
| CN1748802A (en) * | 2005-08-04 | 2006-03-22 | 孙文善 | Use of degradable material suture in acupoint burying |
-
2013
- 2013-09-27 CN CN201310451068.7A patent/CN104511055A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2371974Y (en) * | 1999-05-25 | 2000-04-05 | 王维庭 | Acupuncture medicated needle |
| CN1274574A (en) * | 1999-05-25 | 2000-11-29 | 王维庭 | Medicated acupuncture needle and its making process |
| CN1748802A (en) * | 2005-08-04 | 2006-03-22 | 孙文善 | Use of degradable material suture in acupoint burying |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106310372A (en) * | 2015-06-23 | 2017-01-11 | 上海交通大学 | Degradable magnesium-based bone implant drug-loaded high molecular/calcium-phosphorus composite coating and preparation method |
| CN106310372B (en) * | 2015-06-23 | 2020-05-22 | 上海交通大学 | Degradable magnesium-based implantable drug-carrying polymer/calcium-phosphorus composite coating and preparation |
| CN108543231A (en) * | 2018-05-22 | 2018-09-18 | 北京大学口腔医学院 | A kind of degradable multispectral luminous implantation material |
| CN108543231B (en) * | 2018-05-22 | 2024-04-12 | 北京大学口腔医学院 | Degradable multispectral luminous implant |
| CN112672698A (en) * | 2018-09-17 | 2021-04-16 | 实验室和人们有限公司 | Thread for catgut embedding therapy and needle tool comprising same for catgut embedding therapy |
| CN112672698B (en) * | 2018-09-17 | 2024-07-02 | 实验室和人们有限公司 | Wire for buried wire therapy and needle for buried wire therapy comprising same |
| CN115804872A (en) * | 2022-11-29 | 2023-03-17 | 上海交通大学 | Application of degradable magnesium-based metal wire in preparation of fat dissolving material |
| CN115804872B (en) * | 2022-11-29 | 2024-02-27 | 上海交通大学 | Application of degradable magnesium-based metal wire in preparation of fat-soluble material |
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Application publication date: 20150415 |
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