CN109589307A - 一种核酸适体脂质体的制备方法 - Google Patents
一种核酸适体脂质体的制备方法 Download PDFInfo
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- CN109589307A CN109589307A CN201811378750.7A CN201811378750A CN109589307A CN 109589307 A CN109589307 A CN 109589307A CN 201811378750 A CN201811378750 A CN 201811378750A CN 109589307 A CN109589307 A CN 109589307A
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- aptamer
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- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims abstract description 20
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (8)
Priority Applications (1)
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CN201811378750.7A CN109589307B (zh) | 2018-11-19 | 2018-11-19 | 一种核酸适体脂质体的制备方法 |
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CN201811378750.7A CN109589307B (zh) | 2018-11-19 | 2018-11-19 | 一种核酸适体脂质体的制备方法 |
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CN109589307A true CN109589307A (zh) | 2019-04-09 |
CN109589307B CN109589307B (zh) | 2021-05-14 |
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Citations (5)
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US6242258B1 (en) * | 1997-02-20 | 2001-06-05 | Vanderbilt University | Methods for the selective regulation of DNA and RNA transcription and translation by photoactivation |
CN102702010A (zh) * | 2012-05-23 | 2012-10-03 | 北京大学 | 光敏感的功能化固载相及其制备方法和应用 |
CN104352440A (zh) * | 2014-11-07 | 2015-02-18 | 中国科学院过程工程研究所 | 一种阳离子脂质体核酸类药物制剂及其制备方法和应用 |
CN107648620A (zh) * | 2017-09-13 | 2018-02-02 | 中国人民解放军第三军医大学第附属医院 | 携载caix适体的靶向超声纳米泡及其制备方法 |
CN108795685A (zh) * | 2017-04-28 | 2018-11-13 | 中国科学院苏州纳米技术与纳米仿生研究所 | 微流控芯片、其制法及胎儿有核红细胞捕获与释放方法 |
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2018
- 2018-11-19 CN CN201811378750.7A patent/CN109589307B/zh active Active
Patent Citations (5)
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US6242258B1 (en) * | 1997-02-20 | 2001-06-05 | Vanderbilt University | Methods for the selective regulation of DNA and RNA transcription and translation by photoactivation |
CN102702010A (zh) * | 2012-05-23 | 2012-10-03 | 北京大学 | 光敏感的功能化固载相及其制备方法和应用 |
CN104352440A (zh) * | 2014-11-07 | 2015-02-18 | 中国科学院过程工程研究所 | 一种阳离子脂质体核酸类药物制剂及其制备方法和应用 |
CN108795685A (zh) * | 2017-04-28 | 2018-11-13 | 中国科学院苏州纳米技术与纳米仿生研究所 | 微流控芯片、其制法及胎儿有核红细胞捕获与释放方法 |
CN107648620A (zh) * | 2017-09-13 | 2018-02-02 | 中国人民解放军第三军医大学第附属医院 | 携载caix适体的靶向超声纳米泡及其制备方法 |
Non-Patent Citations (2)
Title |
---|
YUMA YAMADA: "A Dual-Ligand Liposomal System Composed of a Cell-Penetrating", 《JOURNAL OF PHARMACEUTICAL SCIENCES》 * |
李咏梅: "核酸适配体修饰的纳米脂质体的制备及靶向毒性研究", 《化学与生物工程》 * |
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