CN109568340A - A kind of drug for treating stomatitis - Google Patents
A kind of drug for treating stomatitis Download PDFInfo
- Publication number
- CN109568340A CN109568340A CN201811503159.XA CN201811503159A CN109568340A CN 109568340 A CN109568340 A CN 109568340A CN 201811503159 A CN201811503159 A CN 201811503159A CN 109568340 A CN109568340 A CN 109568340A
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- CN
- China
- Prior art keywords
- parts
- vitamin
- drug
- stomatitis
- patch
- Prior art date
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- Granted
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- 208000003265 stomatitis Diseases 0.000 title claims abstract description 44
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- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000011049 pearl Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 208000028529 primary immunodeficiency disease Diseases 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
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- A—HUMAN NECESSITIES
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- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
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- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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Abstract
The present invention provides a kind of drugs for treating stomatitis, belong to pharmaceutical technology field.It include the ingredients such as lactose, lactalbumin and vitamin in the drug for the treatment of stomatitis provided by the invention.The drug for the treatment of stomatitis provided by the invention can effectively treat stomatitis, and effective percentage is 80% or more.Meanwhile ingredient is carbohydrate, inorganic salts and vitamin ingredients in drug, is food grade ingredients, sweet and dilitious, use is safe, has no toxic side effect.
Description
Technical field
The invention belongs to pharmaceutical technology fields, and in particular to a kind of drug for treating stomatitis.
Background technique
Stomatitis, also referred to as canker sore, are the general names of various mucous membrane of mouth inflammation, and symptom is mainly lip inside, cheek, tongue
The mucous membrane of point etc. festers.Because nerve endings distribution is shallow, intensive and sensitive in oral mucosa, although ulcer surface is typically not greater than
0.5cm2, but often patient pain can be enabled unbearably because touching caused by speaking or having a meal.Stomatitis can betide any age, illness
Rate is about 10%, and pathogenic factor is more, predominantly mucous membrane mechanical trauma, endocrine disturbance, gastrointestinal dysfunction, constipation,
Stomach helminth, sleep insufficiency or fatigue, virus and bacteria infection, folic acid or hypovitaminosis etc. cause.In addition to mechanical damage, mouth
The scorching definite cause of disease cannot still define completely so far, academia generally believe its be a variety of element comprehensive functions as a result, its
Drug action mechanism is intricate, and hardly possible is at final conclusion so far.
There are many stomatitis therapeutic agent and method, and curative effect is different.In terms of medicament categories: in Traditional Chinese medical theory, treatment reason
By surrounding " dropping dry reducing internal heat " Lai Zhankai, mainly the Liver Channel stomach meridian stomatitis that intimately rises initiation, and improve immunity, such as watermelon
Frost, Bingpeng San；Doctor trained in Western medicine is usually relieved the pain with the direct anti-inflammatory of the surface of a wound, improves stomatitis caused by immunity or microelement-supplementing shortage.
Such as metronidazole, vitamin B2, aureomycin or Kangfuxin Liquid part spray etc..In addition, the self-healing time of stomatitis is 7~10 days,
Patient will often bear the pain fed, touch, brushed teeth during this period.According to clinical observation, usually using " reducing internal heat, supplement dimension life
The schemes such as element ", competence exertion acts on all before and after the self-healing time.
In terms of dosage form: Chinese medicine has xilei san, Bingpeng San etc., and Western medicine has gargle, patch etc..Powder type is inconvenient for use,
It is easy to be lost with saliva after being applied to affected part.For special stomatitis film, it is domestic it is existing include sharp bacteriolyze enzyme membrane, good fortune flat membrane,
Honeybee royal serous coat, clotrimazole film etc., membrane material are mainly sodium carboxymethylcellulose or polyvinyl alcohol, and are monofilm, it is easy to quilt
Saliva dissolution, retention time is usually a few minutes in the oral cavity, it is difficult to reach effective treatment to ulcer surface.There are also one in the market
The gargle of prevention and treatment stomatitis containing medicinal herb components a bit, taste is bad, cannot eat, in order to prevent stomatitis and gargled using this
Liquid is simultaneously inconvenient, some gargles also have side effect.And the nutrient solution or beverage of some prevention and treatment classes, required time generally can be more
It is long, and preventive effect is greater than treatment.
In terms of invention field: " fruit-vegetable food and preparation method thereof for the treatment of canker sore " 201310135167.4, from
The mode that theory of traditional Chinese medical science removes dryness fall fire is set out, and with " cool property " in theory of traditional Chinese medical science, fruit vegetable powder is auxiliary forms with probiotic powder, and effect is obvious,
But the method takes effect slow, needs patient 3 times a day, and 6 as a treatment course, continuously takes eight courses for the treatment of (i.e. 48 days), general to suffer from
Person is difficult to adhere to accomplishing." a kind of nutrient solution for anti-treating dental ulcer " 201410715383.0, mainly in pure water
It is added to vitamin, flavoring agent and pearl powder, is a kind of functional beverage, mainly from the angle of prevention, it is also desirable to is long
Phase takes supplement body vitamin etc., and prevention effect is greater than treatment." a kind of vinegar beverage with anti-treating dental ulcer effect "
201110040118.3, certain medical components are mainly added in acetic acid beverage, are mainly characterized by the flavor of beverage sour
With certain prevention effect." with patch treatment canker sore to accelerate recovery from illness and lenitive method " 02822064.1 provides
A kind of patch being applied to ulcer surface using drugs such as Radix Glycyrrhizaes and certain time can be maintained, but need to paste daily with 2 hours or more
For a long time.But oral lesions face directly uses Radix Glycyrrhizae, penicillin etc., is equivalent to medicament and directly contacts with human internal environment, secondary
It acts on still to be tested." for treating the bee glue preparation and its preparation method of canker sore " 01107701.8, provides a kind of use
Organic solvent extracts the tincture of effective bee glue components, and when use dips in upper tincture with cotton swab and is applied to ulcer surface, and main function is to make to burst
It benumbs and relieves the pain around ulcer, action time is short, and healing time also needs 7 days or so, and it is similar with the self-healing time, and its organic solvent
Need to be investigated Deng the side effect to human body." dexamethasone acetate plaster and its preparation " CN00132507.8 is using acetic acid
Dexamethasone is the patch of drug, and feedback effects are pretty good on the market, but it is a kind of hormonal drug, cannot be long-term or repeatedly anti-
It is multiple to use, it is long for repetitious canker sore patient Time of Administration to will lead to osteoporosis, fracture or hypoimmunity
Equal side effects.
Therefore, develop it is a can relieve the pain rapidly, safety is without side-effects, quick, simultaneously and can protect the drug of the surface of a wound
Seem especially urgent.
Summary of the invention
In view of this, the present invention provides a kind of drug for treating stomatitis, drug safety, energy quick pain relief, cure rate
It is high.
To solve the above-mentioned problems, the present invention provides following technical schemes:
The present invention provides a kind of drug for treating stomatitis, the active component including following parts by weight: lactose 5500~
6000 parts, 1200~1400 parts of lactalbumin, 800~1000 parts of dietary fibre, 45~55 parts of sodium chloride, calcium carbonate 115~125
Part, 1.15~1.25 parts of ferrous sulfate, 0.85~0.95 part of zinc sulfate, 14.5~15.5 parts of vitamin C, vitamin E 0.95
~1.05 parts, 0.22~0.24 part of riboflavin, 0.00056~0.0006 part of pantothenic acid, 0.060~0.064 part of vitamin A, dimension life
0.0028~0.0032 part of plain D3,0.0048~0.0052 part of vitamin K1,0.00098~0.0012 part of vitamin B12,
0.0028~0.0032 part of biotin, 0.00095~0.0015 part of vitamin B1,0.048~0.052 part of calcium carbonate, iodate
0.018~0.022 part of potassium, 0.0048~0.0052 part of magnesium monohydrogen phosphate, 0.0018~0.0022 part of potassium citrate, magnesium citrate
0.0018~0.0022 part and 0.0009~0.0012 part of potassium phosphate.
Preferably, the active component including following parts by weight: 5700~5900 parts of lactose, lactalbumin 1250~1350
Part, 850~950 parts of dietary fibre, 48~52 parts of sodium chloride, 118~122 parts of calcium carbonate, 1.18~1.22 parts of ferrous sulfate, sulphur
0.88~0.92 part of sour zinc, 14.8~15.2 parts of vitamin C, 0.98~1.02 part of vitamin E, riboflavin 0.225~0.235
Part, 0.00057~0.00059 part of pantothenic acid, 0.061~0.063 part of vitamin A, 0.0029~0.0031 part of vitamine D3, dimension
Raw 0.0049~0.0051 part of element K1,0.00099~0.0011 part of vitamin B12,0.0029~0.0031 part of biotin,
0.00098~0.0013 part of vitamin B1,0.049~0.051 part of calcium carbonate, 0.019~0.021 part of potassium iodide, magnesium monohydrogen phosphate
0.0049~0.0051 part, 0.0019~0.0021 part of potassium citrate, 0.0019~0.0021 part of magnesium citrate and potassium phosphate
0.00098~0.0011 part.
Preferably, the dosage form of the drug includes patch and electuary.
Preferably, when the dosage form is patch, the drug of the treatment stomatitis further include: 1700~2100 parts of palm oil
With 1100~1300 parts of honey.
Preferably, when the dosage form is patch, the medicament contg of the patch is 1~2g/ patch.
Preferably, the patch number of the patch is 3~5 patches/day.
Preferably, when the dosage form is electuary, the drug of the treatment stomatitis further includes fructose；The fructose and activity
The mass ratio of component is 0.8~1.2:1.
Preferably, the electuary dose is 18~22g/ times.
Preferably, it is 3~5 times/day that the electuary, which takes number,.
Preferably, when the electuary is taken after mixing it with water, the quality and water volume ratio of electuary are 18~22g:100mL.
The present invention provides a kind of drug for treating stomatitis, the active component including following parts by weight: lactose 5500~
6000 parts, 1200~1400 parts of lactalbumin, 800~1000 parts of dietary fibre, 45~55 parts of sodium chloride, calcium carbonate 115~125
Part, 1.15~1.25 parts of ferrous sulfate, 0.85~0.95 part of zinc sulfate, 14.5~15.5 parts of vitamin C, vitamin E 0.95
~1.05 parts, 0.22~0.24 part of riboflavin, 0.00056~0.0006 part of pantothenic acid, 0.060~0.064 part of vitamin A, dimension life
0.0028~0.0032 part of plain D3,0.0048~0.0052 part of vitamin K1,0.00098~0.0012 part of vitamin B12,
0.0028~0.0032 part of biotin, 0.00095~0.0015 part of vitamin B1,0.048~0.052 part of calcium carbonate, iodate
0.018~0.022 part of potassium, 0.0048~0.0052 part of magnesium monohydrogen phosphate, 0.0018~0.0022 part of potassium citrate, magnesium citrate
0.0018~0.0022 part and 0.0009~0.0012 part of potassium phosphate.Lactose is as most important ingredient in side, to wound surface
On a large amount of bacteriums carry out osmotic stress, cause bacterium be dehydrated and it is dead, lactose seeps simultaneously compared to other carbohydrates more facile hydrolysis
Saturating ability is also stronger, more preferable to the killing effect of bacterium.The present invention is added to the elements such as calcium, iron, zinc side according to the above ratio simultaneously
It helps local wound Ions Absorption to adjust and heal, while supplementing a variety of vitamins needed by human, to effectively achieve
The effect of prevention recurrence can also be played while healing stomatitis.
Further, in patient in use, patch is affixed on ulcer surface, lactose and fibre composition surface are met water and are condensed into
Macromolecule reticular structure is firmly adsorbed on ulcer surface, without adding individual film to form a natural protection patch
Ulcer surface can be fixed on and slow release.The microorganism (bacterium etc.) of ulcer surface is after the sugar for meeting with high concentration, because extracellular
Osmotic potential reduces rapidly and dehydration is dead, achievees the purpose that anti-inflammatory.The dehydration death of local woanded surface cell is played further simultaneously
Self-protection effect, also pain is eased local nerve due to signal terminating.The vitamin for including in patch is through saliva
Enter human body with the surface of a wound, plays the role of rapid replenishing vitamins；The wound that the elements such as calcium, iron, zinc help part is increased simultaneously
Mouth Ions Absorption adjusts and healing.Because of the secretion of saliva in oral cavity, surface is slowly dissolved entire patch, in the oral cavity the duration
It is 1 hour.Embodiment the result shows that: it is provided by the invention treatment stomatitis drug effective percentage be 80% or more.Meanwhile
Ingredient is the food grade ingredients such as carbohydrate, inorganic salts and vitamin, whole process safety, natural, sweet and dilitious, contracting rapidly in side
The short self-healing time, and have no toxic side effect.
Specific embodiment
The present invention provides a kind of drug for treating stomatitis, the active component including following parts by weight: lactose 5500~
6000 parts, 1200~1400 parts of lactalbumin, 800~1000 parts of dietary fibre, 45~55 parts of sodium chloride, calcium carbonate 115~125
Part, 1.15~1.25 parts of ferrous sulfate, 0.85~0.95 part of zinc sulfate, 14.5~15.5 parts of vitamin C, vitamin E 0.95
~1.05 parts, 0.22~0.24 part of riboflavin, 0.00056~0.0006 part of pantothenic acid, 0.060~0.064 part of vitamin A, dimension life
0.0028~0.0032 part of plain D3,0.0048~0.0052 part of vitamin K1,0.00098~0.0012 part of vitamin B12,
0.0028~0.0032 part of biotin, 0.00095~0.0015 part of vitamin B1,0.048~0.052 part of calcium carbonate, iodate
0.018~0.022 part of potassium, 0.0048~0.0052 part of magnesium monohydrogen phosphate, 0.0018~0.0022 part of potassium citrate, magnesium citrate
0.0018~0.0022 part and 0.0009~0.0012 part of potassium phosphate.
In the present invention, the drug of the treatment stomatitis, preferably includes the active component of following parts by weight: lactose 5700~
5900 parts, 1250~1350 parts of lactalbumin, 850~950 parts of dietary fibre, 48~52 parts of sodium chloride, calcium carbonate 118~122
Part, 1.18~1.22 parts of ferrous sulfate, 0.88~0.92 part of zinc sulfate, 14.8~15.2 parts of vitamin C, vitamin E 0.98
~1.02 parts, 0.225~0.235 part of riboflavin, 0.00057~0.00059 part of pantothenic acid, 0.061~0.063 part of vitamin A,
0.0029~0.0031 part of vitamine D3,0.0049~0.0051 part of vitamin K1, vitamin B12 0.00099~0.0011
Part, 0.0029~0.0031 part of biotin, 0.00098~0.0013 part of vitamin B1,0.049~0.051 part of calcium carbonate,
0.019~0.021 part of potassium iodide, 0.0049~0.0051 part of magnesium monohydrogen phosphate, 0.0019~0.0021 part of potassium citrate, citric acid
0.0019~0.0021 part and 0.00098~0.0011 part of potassium phosphate of magnesium；It include: more preferably 5800 parts of lactose, lactalbumin
1300 parts, 900 parts of dietary fibre, 50 parts of sodium chloride, 120 parts of calcium carbonate, 1.2 parts of ferrous sulfate, 0.9 part of zinc sulfate, vitamin
C15 parts, vitamin e1 part, 0.23 part of riboflavin, 0.00058 part of pantothenic acid, 0.062 part of vitamin A, 0.003 part of vitamine D3,
0.005 part of vitamin K1,0.001 part of vitamin B12,0.003 part of biotin, 0.001 part of vitamin B1, calcium carbonate
0.05 part, 0.02 part of potassium iodide, 0.005 part of magnesium monohydrogen phosphate, 0.002 part of potassium citrate, 0.002 part of magnesium citrate and potassium phosphate
0.001 part.
In the present invention, in the drug of the treatment stomatitis, lactose is as most important ingredient, to big on wound surface
It measures bacterium and carries out osmotic stress, cause bacterium to be dehydrated and dead, lactose is compared to other carbohydrates more facile hydrolysis, while penetrating power
Also stronger, it is more preferable to the killing effect of bacterium.The present invention is added to vitamin according to the above ratio simultaneously, meets human body to vitamin
Demand, be suitable for while increasing calcium supplemented with vitamin, the elements such as iron zinc help the wound Ions Absorption of part to adjust and more
It closes, thus the effect of having effectively achieved healing and prevention stomatitis.
The present invention is not particularly limited the source of above-mentioned active component, using this field conventional commercial product.This
Formula drug in inventive embodiments is purchased from Chinese medicines group, and honey brand is GuanShengYuan pagodatree flower honey.
In the present invention, the dosage form of the drug of the treatment stomatitis preferably includes patch and electuary.In the present invention, described
Patch can be used alone, and can also be used cooperatively with electuary；Preferably electuary and patch is preferably used cooperatively.
In the present invention, when the dosage form is patch, it is also preferable to include palm oils 1700 for the drug of the treatment stomatitis
~2100 parts and 1100~1300 parts of honey, more preferably 1800~2000 parts and 1150~1250 parts of honey of palm oil, it is optimal
It is selected as 1900 parts and 1200 parts of honey of palm oil.In the present invention, when the dosage form is patch, the medicament contg of the patch
Preferably 1~2g/ patch, more preferably 2g/ patch.The patch of the patch is preferably 3~5 patches/day with number, and more preferably 5 patches/
It.
In the present invention, patch being affixed on ulcer surface, water is met on lactose and fibre composition surface and to condense into macromolecule netted,
Form a natural protection patch, be firmly adsorbed on ulcer surface, individual film can be fixed on ulcer surface without adding and
Slow release.Microbial bacterial of ulcer surface etc. is after the sugar for meeting with high concentration, because extracellular osmotic potential reduces rapidly due to dehydration
Death achievees the purpose that anti-inflammatory.Further self-protection is played the role of in the dehydration death of local woanded surface cell simultaneously, local
Also pain is eased nerve due to signal terminating.The vitamin for including in patch enters human body through saliva and the surface of a wound, plays fast
The effect of fast replenishing vitamins；Increasing the elements such as calcium, iron, zinc simultaneously helps the wound Ions Absorption of part to adjust and heal.
Entire patch is because of salivary secretion in oral cavity, and surface is slowly dissolved, and the duration is 1 hour in the oral cavity.
In the present invention, when the dosage form is electuary, it is also preferable to include fructose for the drug of the treatment stomatitis；The fruit
Sugar and the mass ratio of active component are preferably 0.8~1.2:1, more preferably 1:1.In the present invention, the electuary dose is excellent
It is selected as 18~22g/ times, more preferably 20g.The number of taking of the electuary is preferably 4~5 times/day, and more preferably 5 times/day.
The Time of Administration of the electuary is preferably the interval time removed in patch.
In the present invention, when the electuary is taken after mixing it with water, the quality and water volume ratio of electuary are preferably 18~22g:100mL,
More preferably 20g:100mL.
The present invention is not particularly limited the preparation method of the drug, and each component is mixed using usual manner.
In order to further illustrate the present invention, technical solution provided by the invention is retouched in detail below with reference to embodiment
It states, but they cannot be interpreted as limiting the scope of the present invention.
Embodiment 1
It is sub- to weigh lactose 5.5Kg, lactalbumin 1.4Kg, dietary fibre 0.8Kg, sodium chloride 55g, calcium carbonate 115g, sulfuric acid
Iron 1.25g, zinc sulfate 0.85g, vitamin C 15.5g, vitamin E 0.95g, riboflavin 0.24g, pantothenic acid 0.00056g, dimension life
Plain A 0.064g, vitamine D3 0.0028g, vitamin K1 0.0052g, vitamin B12 0.00098g, biotin
0.0032g, vitamin B1 0.00095g, calcium carbonate 0.052g, potassium iodide 0.018g, magnesium monohydrogen phosphate 0.0052g, potassium citrate
0.0018g, magnesium citrate 0.0022g and potassium phosphate 0.0009g.Will after the above components are mixed with palm oil 1.7Kg, honey
1.3Kg is stirred evenly, and obtains paste patch blank, later by the circular patch of paste patch diameter 0.8cm, height 0.1cm
Shaper sizing, obtain medical treatment patch.
Except honey and palm oil is not added, other raw materials are identical with the above-mentioned patch for preparing with additive amount, add simultaneously
The mixing of 1.6Kg fructose, obtains electuary.
Embodiment 2
Weigh lactose 6Kg, lactalbumin 1.2Kg, dietary fibre 1Kg, sodium chloride 45g, calcium carbonate 125g, ferrous sulfate
1.15g, zinc sulfate 0.95g, vitamin C 14.5g, vitamin E 1.05g, riboflavin 0.22g, pantothenic acid 0.0006g, vitamin A
0.060g, vitamine D3 0.0032g, vitamin K1 0.0048g, vitamin B1 20.0012g, biotin 0.0028g, dimension
Raw element B1 0.0015g, calcium carbonate 0.048g, potassium iodide 0.022g, magnesium monohydrogen phosphate 0.0048g, potassium citrate 0.0022g, lemon
Sour magnesium 0.0018g and potassium phosphate 0.0012g.It will stir evenly, obtain with palm oil 2.1Kg, honey 1.1Kg after the above components are mixed
To paste patch blank, the circular patch shaper of paste patch diameter 0.8cm, height 0.1cm are formed later,
Obtain medical treatment patch.
Except honey and palm oil is not added, other raw materials are identical with the above-mentioned patch for preparing with additive amount, add simultaneously
The mixing of 2.4Kg fructose, obtains electuary.
Embodiment 3
It is sub- to weigh lactose 5.8Kg, lactalbumin 1.3Kg, dietary fibre 0.9Kg, sodium chloride 50g, calcium carbonate 120g, sulfuric acid
Iron 1.2g, zinc sulfate 0.9g, vitamin C 15g, vitamin e1 g, riboflavin 0.23g, pantothenic acid 0.00058g, vitamin
A0.062g, vitamine D3 0.003g, vitamin K1 0.005g, vitamin B12 0.001g, biotin 0.003g, vitamin
B1 0.001g, calcium carbonate 0.05g, potassium iodide 0.02g, magnesium monohydrogen phosphate 0.005g, potassium citrate 0.002g, magnesium citrate
0.002g and potassium phosphate 0.001g.It will be stirred evenly after the above components are mixed with palm oil 1.9Kg, honey 1.2Kg, obtain paste
The circular patch shaper of paste patch diameter 0.8cm, height 0.1cm are formed later, are controlled by patch blank
Treat patch.
Except honey and palm oil is not added, other raw materials are identical with the above-mentioned patch for preparing with additive amount, add simultaneously
The mixing of 2Kg fructose, obtains electuary.
Embodiment 4
150 volunteers for suffering from stomatitis are randomly selected, above-mentioned member is randomly divided into 3 groups, it every group 50, will be of the invention
Patch be affixed on patient's ulcer surface, do not fed after sticking and keep 0.5~1h under conditions of drinking water, daily patch 5 times, between patch
Gap oral granule 3 times.The 3rd day statistics be efficient, counts cure rate behind the 5th day and the 7th day taking respectively.Concrete outcome such as table
Shown in 1.
1 stomatitis drug effective percentage of table and cure rate statistics
Note: subitem statistics pain relief and ulcer reduce between number have an intersection, efficiently individual quantity be not only pain relief but also
What ulcer surface reduced.Cure rate indicates that ulcer surface healing, pain disappear.
As can be seen from Table 1, using patch significant effect of the invention after patch 3 days, 80% or more people's pain in 3 groups
Pain is all alleviated, and illustrating this medicament largely reduces the pain of patient；Wherein the pain of embodiment 3 is reduced
And the effective percentage of ulcer surface reduction has reached 82%, embodiment 1 and embodiment 2 have respectively reached 70% and 68%.Implement after 5 days
The effective percentage of example 3 has reached 96%, cure rate and has reached 90%；The cure rate of embodiment 1 and embodiment 2 has respectively reached 82%
With 80%.The cure rate of Examples 1 to 3 is respectively 96%, 94%, 98% after 7 days.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of drug for treating stomatitis, which is characterized in that the active component including following parts by weight: lactose 5500~6000
Part, 1200~1400 parts of lactalbumin, 800~1000 parts of dietary fibre, 45~55 parts of sodium chloride, 115~125 parts of calcium carbonate,
1.15~1.25 parts of ferrous sulfate, 0.85~0.95 part of zinc sulfate, 14.5~15.5 parts of vitamin C, vitamin E 0.95~
1.05 parts, 0.22~0.24 part of riboflavin, 0.00056~0.0006 part of pantothenic acid, 0.060~0.064 part of vitamin A, vitamin
D30.0028~0.0032 part, 0.0048~0.0052 part of vitamin K1,0.00098~0.0012 part of vitamin B12, vitamin
H0.0028~0.0032 part, vitaminB10 .00095~0.0015 part, 0.048~0.052 part of calcium carbonate, potassium iodide 0.018
~0.022 part, 0.0048~0.0052 part of magnesium monohydrogen phosphate, 0.0018~0.0022 part of potassium citrate, magnesium citrate 0.0018~
0.0022 part and 0.0009~0.0012 part of potassium phosphate.
2. the drug for the treatment of stomatitis according to claim 1, which is characterized in that the active component including following parts by weight:
5700~5900 parts of lactose, 1250~1350 parts of lactalbumin, 850~950 parts of dietary fibre, 48~52 parts of sodium chloride, carbonic acid
118~122 parts of calcium, 1.18~1.22 parts of ferrous sulfate, 0.88~0.92 part of zinc sulfate, 14.8~15.2 parts of vitamin C, dimension
Raw 0.98~1.02 part of element E, 0.225~0.235 part of riboflavin, 0.00057~0.00059 part of pantothenic acid, vitamin A 0.061
~0.063 part, 0.0029~0.0031 part of vitamine D3,0.0049~0.0051 part of vitamin K1, vitamin B12 0.00099
~0.0011 part, 0.0029~0.0031 part of biotin, vitaminB10 .00098~0.0013 part, calcium carbonate 0.049~
0.051 part, 0.019~0.021 part of potassium iodide, 0.0049~0.0051 part of magnesium monohydrogen phosphate, potassium citrate 0.0019~0.0021
Part, 0.0019~0.0021 part of magnesium citrate and 0.00098~0.0011 part of potassium phosphate.
3. the drug for the treatment of stomatitis according to claim 1 or 2, which is characterized in that the dosage form of the drug includes patch
And electuary.
4. the drug for the treatment of stomatitis according to claim 3, which is characterized in that described to control when the dosage form is patch
Treat the drug of stomatitis further include: 1700~2100 parts and 1100~1300 parts of honey of palm oil.
5. the drug for the treatment of stomatitis according to claim 4, which is characterized in that when the dosage form is patch, the patch
The medicament contg of agent is 1~2g/ patch.
6. it is according to claim 4 or 5 treatment stomatitis drug, which is characterized in that the patch number of the patch be 3~
5 patches/day.
7. the drug for the treatment of stomatitis according to claim 3, which is characterized in that described to control when the dosage form is electuary
The drug for treating stomatitis further includes fructose；The fructose and the mass ratio of active component are 0.8~1.2:1.
8. the drug for the treatment of stomatitis according to claim 7, which is characterized in that the electuary dose is 18~22g/
It is secondary.
9. the drug for the treatment of stomatitis according to claim 7 or 8, which is characterized in that it is 3~5 that the electuary, which takes number,
Times/day.
10. the drug for the treatment of stomatitis according to claim 7 or 8, which is characterized in that when the electuary is taken after mixing it with water, electuary
Quality and water volume ratio be 18~22g:100mL.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811503159.XA CN109568340B (en) | 2018-12-10 | 2018-12-10 | Medicine for treating stomatitis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811503159.XA CN109568340B (en) | 2018-12-10 | 2018-12-10 | Medicine for treating stomatitis |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4406882A (en) * | 1981-02-06 | 1983-09-27 | Biorex Laboratories Limited | Pharmaceutical composition for treating diseases of the oral cavity |
| CN1074920A (en) * | 1991-05-29 | 1993-08-04 | 伯温得药品服务股份有限公司 | Film coating and film coating composition based on cellulose polymer compound and lactose |
| CN1718239A (en) * | 2005-01-28 | 2006-01-11 | 深圳市孚沃德生物技术有限公司 | Oral adhering piece for treating oral exulceratio, and its prepn. method |
| CN101371845A (en) * | 2007-08-23 | 2009-02-25 | 天津药业集团有限公司 | Medicament composition for curing mouth ulcer |
-
2018
- 2018-12-10 CN CN201811503159.XA patent/CN109568340B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4406882A (en) * | 1981-02-06 | 1983-09-27 | Biorex Laboratories Limited | Pharmaceutical composition for treating diseases of the oral cavity |
| CN1074920A (en) * | 1991-05-29 | 1993-08-04 | 伯温得药品服务股份有限公司 | Film coating and film coating composition based on cellulose polymer compound and lactose |
| CN1718239A (en) * | 2005-01-28 | 2006-01-11 | 深圳市孚沃德生物技术有限公司 | Oral adhering piece for treating oral exulceratio, and its prepn. method |
| CN101371845A (en) * | 2007-08-23 | 2009-02-25 | 天津药业集团有限公司 | Medicament composition for curing mouth ulcer |
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| Title |
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| 沈再朗等: "《现代临床药物新用》", 31 August 2000, 浙江科学技术出版社 * |
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