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CN109511655A - A kind of bactericidal composition - Google Patents

A kind of bactericidal composition Download PDF

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Publication number
CN109511655A
CN109511655A CN201710839742.7A CN201710839742A CN109511655A CN 109511655 A CN109511655 A CN 109511655A CN 201710839742 A CN201710839742 A CN 201710839742A CN 109511655 A CN109511655 A CN 109511655A
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CN
China
Prior art keywords
sulfonic acid
fluazinam
acid
component
sulfonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710839742.7A
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Chinese (zh)
Inventor
周惠中
董广新
崔勇
孙琴
李志念
丑靖宇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Yangnong Chemical Co Ltd
Shenyang Sinochem Agrochemicals R&D Co Ltd
Original Assignee
Shenyang Sinochem Agrochemicals R&D Co Ltd
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Application filed by Shenyang Sinochem Agrochemicals R&D Co Ltd filed Critical Shenyang Sinochem Agrochemicals R&D Co Ltd
Priority to CN201710839742.7A priority Critical patent/CN109511655A/en
Publication of CN109511655A publication Critical patent/CN109511655A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Toxicology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

本发明属农用杀菌剂领域，尤其涉及一种杀菌组合物。组合物为A组分和B组分，按重量比为1‑99：99‑1混合；其中A组分为活性组分为氟啶胺、氟啶胺农业上可接受的盐或氟啶胺与羧酸吗啉类杀菌剂组成的混合物，B组分为非活性组分磺酸盐类化合物。本发明组合物制成的制剂可用于农业生产上防治由卵菌引起的病害的防治，且增效作用明显，尤其对黄瓜霜霉病、西瓜疫病、辣椒疫病、马铃薯晚疫病和葡萄霜霉病等有特效，符合当前农药控制总量减排的和谐发展理念。The invention belongs to the field of agricultural fungicides, in particular to a fungicide composition. The composition is A component and B component, mixed in a weight ratio of 1-99:99-1; wherein the active component of A component is fluazinam, the agriculturally acceptable salt of fluazinam or fluazinam It is a mixture composed of carboxylic acid morpholine fungicides, and component B is an inactive component sulfonate compound. The preparation made from the composition of the present invention can be used in the prevention and control of diseases caused by oomycetes in agricultural production, and the synergistic effect is obvious, especially for cucumber downy mildew, watermelon blight, pepper blight, potato late blight and grape downy mildew etc. have special effects, in line with the current concept of harmonious development of total pesticide control and emission reduction.

Description

A kind of bactericidal composition
Technical field
The invention belongs to disinfectant use in agriculture field more particularly to a kind of bactericidal compositions.
Background technique
Fluazinam is aniline fungicides, has wide sterilization spectrum, mould to interlink spore genus, Botrytis, Phytophthora, single shaft Category, Sclerotinia and Venturia bacterium are highly effective, such as gray mold of cucumber, rot disease, downy mildew, anthracnose, powdery mildew, stem Rot disease, tomato late blight, scab of apple, leaf spot, Pear black spot, rust, rice sheath blight disease, rice blast, grape grey mold Disease, downy mildew, citrus scab, the late blight of potato, lawn spot disease.Fluazinam applicable crops are wide, as grape, apple, pears, Citrus, wheat, soybean, potato, tomato, rice, tea, lawn etc., other than bactericidal activity, fluazinam is also shown to red spider The acaricidal activity of spider etc., such as to engrave mite, the prevention and treatment of kamisawa tetranychus also effective for citrus red mite, China pink.Although fluazinam is to perhaps More plant disease pathogens have good bactericidal activity, but since it is without uptake and translocation, so that it is through plant surface layer The protective layers such as cuticula, wax acquire a certain degree of difficulty, and how to make fluazinam that can penetrate plant surface and enter in plant, play it Feature resolves fluazinam control efficiency, is the problem that current technology faces.
Domestic and international company has many reports such as mixed with suitable fungicide and by increasing appropriate in order to solve the above problem The means such as effect agent, the suitable dosage form of searching attempt to solve the problems, such as this.If Chinese patent CN101731254A is the general letter agriculture of Shenzhen promise Change in mixture filed on January 8th, 2010, flumorph-fluazinam mixture patent disclosed on June 16th, 2010, but at present The patent has been abandoned, and CN101755798A is that Xinnong Dazheng Biological Engineering Co., Ltd., Fujian applied on November 23rd, 2009, Flumorph-fluazinam mixture patent disclosed on June 30th, 2010, but the patent has been abandoned at present.WO2001084930A (CN1198503C) it is the PCT Patent of LG Corp of South Korea application while has also applied for Chinese invention patent and being authorized the date of application For on May 9th, 2001, authorization date was on April 27th, 2005, for the synergistic composition containing polyalkylene ether and fluazinam. CN101984815A (B) is that Jiangyin Suli Chemicals Co., Ltd. applied on July 15th, 2010 and on March 27th, 2013 The Chinese invention patent being authorized, a kind of fluazinam dry suspending agent and preparation method thereof.WO2013087395A [CN103997891A (B)] is Syngenta Co., Ltd's application PCT Patent while applying for Chinese patent and being authorized, as agrochemicals The aromatic phosphoric ester aromatic phosphoric ester of preparation component combines at least one agricultural chemicals and optionally at least one Surface activator composition.But being now badly in need of one kind can make fluazinam improve its bioactivity and the group to Target crops safety Close object.
Summary of the invention
The object of the present invention is to provide a kind of synergistic composition and its for prevention and treatment in agricultural production by oomycetes subclass cause of disease The application in disease control that bacterium generates.
To achieve the above object, the invention adopts a technical scheme as:
A kind of bactericidal composition, composition are component A and B component, are mixed by weight for 1-99:99-1；Wherein, A group It is divided into fluazinam or fluazinam agriculturally acceptable salt, B component is Sulfonates compound.
The component A can also agriculturally acceptable salt mixes group with carboxylic acid morpholin's class fungicide for fluazinam or fluazinam At mixture.
It is preferred that the component A and B component, mix by weight for 1-50:1-20.
Further preferably, the component A and B component are mixed by weight for 1-30:1-10.
Still more preferably it is the component A and B component, is mixed by weight for 3-6:1.
The fluazinam or fluazinam agriculturally acceptable salt and carboxylic acid morpholin's class fungicide, weight ratio 10- 20:5-50；Wherein: carboxylic acid morpholin's class fungicide is flumorph, dimethomorph, pyrimorph；
Optimum ratio is 10-15:20-40；
It is further preferred are as follows: 1:1-2.
The Sulfonates compound is C12~22Alkane sulfonic acid, C8~12Alkyl benzene sulphonate, C8~12The formaldehyde of alkyl benzene sulphonate Condensation product, the formaldehyde condensation products of cresol sulfonic acid, α-C14~16Alkene sulfonic acid, C8~12Dialkyl sulfosuccinic acids, lignin sulfonic acid, Polyoxyethylene (list or two) C8~12Alkyl phenyl ether sulfonic acid, polyoxyethylene C12~18Alkyl ether sulfosuccinic acid semiester, naphthalene sulfonic acids, (list or two) C1~6Alkyl naphthalene sulfonic acid, the formaldehyde condensation products of naphthalene sulfonic acids, (list or two) C1~6The formaldehyde condensation products of alkyl naphthalene sulfonic acid, Formaldehyde condensation products, the C of creasote sulfonic acid8~12Alkyl diphenyl base ether disulfonic acid, polystyrolsulfon acid and styrene sulfonic acid and methyl One of salt of the copolymer of acrylic acid or above-mentioned sulfonic acid or in which it is several.
The Sulfonates compound is di-2-ethylhexylphosphine oxide naphthalene sulfonate, heptadecyl benzimidazole sulfonate, benzene sulfonamide Hydrochlorate, alkylnaphthalene sulfonate, alkylsulfonate, alpha-alkene sulfonate, alpha-sulfo fatty acid ester, interior sulfo fatty acid ester, alkyl Sulfosuccinate, fatty acid isethionates, acyl methylamine alkane sulfonate, ether sulfonate, lignosulfonates, petroleum sulphur It is one or more of in hydrochlorate.
A kind of application of bactericidal composition, the composition are prevented and treated in agricultural production in agricultural disease caused by egg bacteria Application.
A kind of preparation containing bactericidal composition, for preparation using bactericidal composition as active component, active component accounts for weight of formulation 5-70%；Preferably 10-30%.
The preparation further includes auxiliary agent and/or adjuvant；Wherein, auxiliary agent is non-ionic additive, disintegrating agent, binder, load One or more of body, thickener；Adjuvant be one of antifreezing agent, defoaming agent, fungi-proofing mould inhibitor, colorant and salt or It is several to be used in combination.
The non-ionic additive is polyethylene glycol type surfactant, EPE polyol EPE, alkyne series surface-active One or more of agent, other surfactants.
The defoaming agent is selected from organic silicone, C8-10Fatty alcohol, C10-20Saturated fatty acid race hydroxyl and its esters, ester- One or more of ether type compound.
The antifreezing agent is ethylene glycol, diethylene glycol (DEG), propylene glycol and glycerol etc.；Preferably propylene glycol, glycerol.
The non-ionic additive is mainly selected from polyethylene glycol type surfactant: can enumerate for example, polyxyethylated (C12~18) ether, the ethylene oxide adduct of alkyl naphthol, polyoxyethylene (list or two) alkyl (C8~12) phenyl ether, polyoxyethylene (list or two) alkyl (C8~12) phenyl ether formaldehyde condensation products, polyoxyethylene (mono-, di- or three) phenyl ether, polyoxyethylene (mono-, di- or three) benzyl phenyl ether, polyoxypropylene (mono-, di- or three) benzyl phenyl ether, polyoxyethylene (mono-, di- or three) styrene Base phenyl ether, polyoxypropylene (mono-, di- or three) styrylphenyl ether, polyoxyethylene (mono-, di- or three) styrylphenyl ether Polymer, polyoxyethylene polyoxypropylene block polymer, alkyl (C12~18) polyoxyethylene polyoxypropylene block polymer ether, Alkyl (C8~12) phenyl polyoxyethylene polyoxypropylene block polymer ether, the double phenyl ether of polyoxyethylene, polyoxyethylene resin acid ester, Polyoxyethylene fatty acid (C12~18) monoesters, polyoxyethylene fatty acid (C12~18) diester, polyoxyethylene sorbitan fatty acid (C12~18) ester, fatty acid glyceride ethylene oxide adduct, Emulsifier EL-60 ether, hardened castor oil ethylene oxide addition Object, alkyl (C12~18) amine ethylene oxide adduct and fatty acid (C12~18) amide ethylene oxide adduct etc..Polyol type surface Activating agent: can enumerate for example, fatty acid glyceride, polyglyceryl fatty acid ester, pentaerythritol fatty ester, polyoxyethylensorbitan fatty acid (C12~18) ester, sorbitan fatty acid (C12~18) ester, sucrose fatty ester, polyol alkyl ether and fatty acid chain alkanol Amide etc..Alkyne series surfactant: can enumerate for example, acetylenediol, acetylene alcohol, acetylenediol ethylene oxide adduct and alkynes Belong to the ethylene oxide adduct etc. of alcohol.Other surfactants: can enumerate for example, alkyl glycosides etc..One or more.It is described Disintegrating agent be selected from one of urea, ammonium sulfate, sodium sulphate, bentonite, carboxy-propyl cellulose, crosslinked starch, white carbon black or It is several.The binder is selected from: starch, CMC, dextrin, sucrose, xanthan gum, Arabic gum, polyvinyl alcohol, polyethylene glycol, silicon It is one or more of in sour sodium, gelatin.It is de- that the carrier is selected from kaolin, bentonite, clay, diatomite, precipitated calcium carbonate, illiteracy One or more of soil, talcum powder, fertilizer such as ammonium sulfate, ammonium phosphate, ammonium nitrate, ureas；And the product of plant origin is such as Flour, bark powder, wood powder and shuck powder, cellulose powder and other solid carriers.Thickener be mainly selected from organic xanthan gum, The heteroglycan such as Weilan gum, guar gum, enlightening spy glue, rhamsan gum and locust bean gum, polyvinylpyrrolidone, gather polyvinyl alcohol The synthesizing water-solubilities such as acrylic acid, Sodium Polyacrylate and polyacrylamide high-molecular compound, methylcellulose, carboxy methylcellulose The cellulose derivatives such as element, carboxy ethyl cellulose, hydroxy ethyl cellulose and hydroxy propyl cellulose, and inorganic cover it is de- Stone, saponite, hectorite, bentonite, beidellite, nontronite, sauconite, humite, synthetic soapstone (laponite) and It synthesizes in the white carbons such as smectite clay minerals, aqueous silicon dioxide, anhydride silica and the hydrosilicates such as smectite It organic is used in combination in one or with inorganic.Specific such as commercially available NPS, EFW, NNO, CNF, MF, 6008, naphthalene sulfonic acids are (such as AkzoNobel D425, U.S.A.), dibutyl naphthalenesulfonic acid (type, German BASF), Norway's Borregard lignin, virtue Therein any one or a few of REAX lignin etc. is used in combination.
The preparation can be made into suspending agent, suspended emulsion, dispersible oil-suspending agent, wettable powder, water-dispersible granule Agent, granule, tablet, micro-capsule suspension or microcapsule granule.
A kind of application of the preparation containing bactericidal composition, the preparation prevent and treat agricultural caused by egg bacteria in agricultural production Application in disease.
Advantage for present invention:
The increasing of acceptable salt and Sulfonates composition on microbicide compositions containing fluazinam of the present invention and agricultural production Effect composition and its application for preventing and treating disease caused by egg bacteria in agricultural production, specifically:
1. bactericidal composition of the present invention using fluazinam and sulfonate in the case where being used in combination, synergistic composition has more Good bactericidal activity, in the case where reducing by 30% pesticide total quantity, the synergistic composition preparation of containing fluazinam is still to many phytopathies Opportunistic pathogen of falling ill has good bactericidal activity, and safer to Target crops, in the case where guaranteeing drug effect, meets current energy conservation The Green Development theory of emission reduction.
2. bactericidal composition preparation of the present invention, which is greatly improved, finds expression in its good dispersion to the control efficiency of crop disease, The features such as wetability is good, suspensibility is high, penetration is strong can be penetrated into plant by blade surface layer；System of the invention simultaneously Agent adhesive force is strong, is resistant to rainwater and charges, the lasting period is long.Dosage capable of reducing using reduces the use cost of user and to environment Negative effect, and present invention combination have it is significant building performance.
3. the dosage of associativity fungicide of the invention determines containing for active component in combination with applicable crops field rate Amount, and then the unrestricted choice of substance between composition is embodied, then each component is mixed with random order or simultaneously, with art technology Processing method known to personnel obtains required preparation, such as suspending agent, suspended emulsion, dispersible oil-suspending agent, wettable powder Agent, water-dispersible granules, granule or micro-capsule suspension and microcapsule granule but it is not limited to above-mentioned dosage form.
Specific embodiment:
Next combined with specific embodiments below invention is further explained, but does not limit the invention to these tools Body embodiment.One skilled in the art would recognize that present invention encompasses may include in Claims scope All alternatives, improvement project and equivalent scheme.It tells that various articles are commercial product in implementation column, removes non-specifically sound Bright, additive amount is weight percentage.
Embodiment 1:30% fluazinam suspending agent
Processing method summary: pressing recipe requirements, will first be added in high shear machine after raw medicine, surfactant, carrier metering Corase grinding is then injected into sand mill and is finely ground to material qualification, discharging packaging.
Comparative example 1:30% fluazinam suspending agent
It is in active component not adding Sulfonates auxiliary agent with 1 difference of embodiment, specific ingredient are as follows:
Processing method summary: pressing recipe requirements, will first be added in high shear machine after raw medicine, surfactant, carrier metering Corase grinding is then injected into sand mill and is finely ground to material qualification, discharging packaging.
Embodiment 2:60% fluazinam water-dispersible granules
Processing method: being processed with " wet process " well-known to those skilled in the art, by recipe requirements, is helped various Agent, filler are added to the mixer after raw medicine metering, start stirring, after mixing, into being sanded in sand mill.It will add The good suspending agent of work is granulated by shaking fluid-bed granulation equipment to get 60% fluazinam water-dispersible granules product.
Comparative example 2:60% fluazinam water-dispersible granules, specific ingredient are as follows:
Processing method: being processed with " wet process " well-known to those skilled in the art, by recipe requirements, is helped various Agent, filler are added to the mixer after raw medicine metering, start stirring, after mixing, into being sanded in sand mill.It will add The good suspending agent of work is granulated by shaking fluid-bed granulation equipment to get 60% fluazinam water-dispersible granules product.
Embodiment 3:20% fluazinam-flumorph suspending agent
Processing method summary: pressing recipe requirements, will first be added in high shear machine after raw medicine, surfactant, carrier metering Corase grinding is then injected into sand mill and is finely ground to material qualification, discharging packaging.
Embodiment 4:20% fluazinam-flumorph suspending agent
Processing method summary: pressing recipe requirements, will first be added in high shear machine after raw medicine, surfactant, carrier metering Corase grinding is then injected into sand mill and is finely ground to material qualification, discharging packaging.
Comparative example 4:20% fluazinam-flumorph suspending agent, specific ingredient are as follows:
Processing method summary: pressing recipe requirements, will first be added in high shear machine after raw medicine, surfactant, carrier metering Corase grinding is then injected into sand mill and is finely ground to material qualification, discharging packaging.
Embodiment 5:60% fluazinam-flumorph water-dispersible granules
Processing method: being processed with " wet process " well-known to those skilled in the art, by recipe requirements, is helped various Agent, filler are added to the mixer after raw medicine metering, start stirring, after mixing, into being sanded in sand mill.It will add The good suspending agent of work is granulated by shaking fluid-bed granulation equipment to get 60% fluazinam-flumorph water-dispersible granule Agent product.
Comparative example 5:60% fluazinam-flumorph water-dispersible granules, specific ingredient are as follows:
Processing method: being processed with " wet process " well-known to those skilled in the art, by recipe requirements, is helped various Agent, filler are added to the mixer after raw medicine metering, start stirring, after mixing, into being sanded in sand mill.It will add The good suspending agent of work is by being granulated by shaking fluid-bed granulation equipment to get 60% fluazinam-flumorph water dispersible Granule product.
Embodiment 6:30% fluazinam-dimethomorph suspending agent
Processing method summary: pressing recipe requirements, will first be added in high shear machine after raw medicine, surfactant, carrier metering Corase grinding is then injected into sand mill and is finely ground to material qualification, discharging packaging.
Comparative example 6:30% fluazinam-dimethomorph suspending agent, specific ingredient are as follows:
Processing method summary: pressing recipe requirements, will first be added in high shear machine after raw medicine, surfactant, carrier metering Corase grinding is then injected into sand mill and is finely ground to material qualification, discharging packaging.
Embodiment 7:60% fluazinam-dimethomorph water-dispersible granules
Processing method: being processed with " wet process " well-known to those skilled in the art, by recipe requirements, is helped various Agent, filler are added to the mixer after raw medicine metering, start stirring, after mixing, into being sanded in sand mill.It will add The good suspending agent of work is granulated by shaking fluid-bed granulation equipment to get 60% fluazinam-dimethomorph water dispersible Granula product.
Comparative example 7:60% fluazinam-dimethomorph water-dispersible granules, specific ingredient are as follows:
Processing method: being processed with " wet process " well-known to those skilled in the art, by recipe requirements, is helped various Agent, filler are added to the mixer after raw medicine metering, start stirring, after mixing, into being sanded in sand mill.It will add The good suspending agent of work is granulated by shaking fluid-bed granulation equipment to get 60% fluazinam-dimethomorph water dispersible Granula product.
Embodiment 8:30% fluazinam-pyrimorph suspending agent
Processing method summary: pressing recipe requirements, will first be added in high shear machine after raw medicine, surfactant, carrier metering Corase grinding is then injected into sand mill and is finely ground to material qualification, discharging packaging.
Comparative example 8:30% fluazinam-pyrimorph suspending agent, specific ingredient are as follows:
Processing method summary: pressing recipe requirements, will first be added in high shear machine after raw medicine, surfactant, carrier metering Corase grinding is then injected into sand mill and is finely ground to material qualification, discharging packaging.
Oil-suspending agent can be dispersed in embodiment 9:20% fluazinam-flumorph
Processing method summary: pressing recipe requirements, will first be added in high shear machine after raw medicine, surfactant, carrier metering Corase grinding is then injected into sand mill and is finely ground to material qualification, discharging packaging.
Embodiment 10:20% fluazinam-flumorph wettable powder
Processing method summary: material is sufficiently mixed in mixing machine, reuses ultrafine crusher commonly used in the art Or airslide disintegrating mill is crushed, and the wettable powder is obtained.
Embodiment 11:20% fluazinam-flumorph tablet
Processing method summary: material is sufficiently mixed in mixing machine, reuses ultrafine crusher commonly used in the art Or airslide disintegrating mill is crushed, and does beat piece after mixing；
Embodiment 12:10% fluazinam-flumorph granule
Processing method summary: material is sufficiently mixed in mixing machine, reuses ultrafine crusher commonly used in the art Or airslide disintegrating mill is crushed, and obtains material and add to obtain granule with vibration vulcanization bed shaking-sieving after 10% wet granulation of water Product.
Embodiment 13:15% fluazinam-flumorph micro-capsule suspension
Processing method summary: step 1, Lauxite, solvent naphtha and the sorbitan monooleate of addition, at 80 degree Stirring 30 minutes, heat preservation for standby use；Flumorph, fluazinam, sulfomethylated lignin disulfonate acid, 4914, water is added in sand mill in step 2 It is middle to be sanded 3 hours, when granularity average grain diameter is less than 5 microns, discharging.Under high speed agitation by the capsule skin droplets of material of preparation Enter containing flumorph, fluazinam mixed liquor in, stir at low speed be added curing agent make capsule skin solidification to get product.
Embodiment 14:15% fluazinam-flumorph microcapsules dry particl agent
Processing method summary: step 1, Lauxite, solvent naphtha and the sorbitan monooleate of addition, at 80 degree Stirring 30 minutes, heat preservation for standby use；Flumorph, fluazinam, sulfomethylated lignin disulfonate acid, 4914, water is added in sand mill in step 2 It is middle to be sanded 3 hours, when granularity average grain diameter is less than 5 microns, discharging.Under high speed agitation by the capsule skin droplets of material of preparation Enter containing flumorph, fluazinam mixed liquor in, curing agent be added make the solidification of capsule skin to get micro-capsule suspension stirring at low speed, The agent of microcapsules dry particl is both obtained after spray drying
Comparative example 14:15% fluazinam-pyrimorph suspended emulsion, specific ingredient are as follows:
Processing method summary: pressing recipe requirements, will first be added in high shear machine after raw medicine, surfactant, carrier metering Corase grinding is then injected into sand mill and is finely ground to material qualification, discharging packaging.
Application examples:
Preparation is obtained to above-described embodiment and comparative example 1-7 and carries out bioactivity (cucumber downy mildew protectiveness) and peace Full property (cucumber) measurement of crop:
It (first sprays and is inoculated with afterwards) using potting Seedling Method, target cucumber downy mildew.Embodiment and comparative example 1-7 are obtained Different preparations are respectively configured concentration and are set as 10,7.5,5,2.5, (mg/L) gradient, 3 repetitions of every processing.Selection growth is neat Consistent 2-3 leaf phase potting cucumber seedling carries out foliar spray processing, separately sets the blank control for spraying clear water.Second day after processing Inoculating spores suspension, phjytotron is placed after inoculation, and (temperature: relative humidity: 25 DEG C of daytime, 20 DEG C of night 95~100%) protect Greenhouse (25 DEG C ± 4 DEG C) normal management is placed in wet culture afterwards for 24 hours.7d investigation prevention effect after inoculation；Simultaneously not apply medicament Blank as control, disease refers to be 100%.
Cucumber downy mildew disease survey method: result investigation can write " A Manual of referring to U.S.'s pathology of plants Assessment Keys for Plant Diseases ", it is indicated with 100-0, disease-free or control efficiency is represented with " 100 " grade The occurring degree or control efficiency 0% of most serious are represented up to 100% and " 0 " grade.
Test result is shown in Table 1
Each embodiment of table 1. and comparative example 1-7 are to cucumber downy mildew control efficiency:
By the visible bactericidal composition of the present invention of said effect data the case where being used in combination using fluazinam and sulfonate Under, synergistic composition has better bactericidal activity, compared to existing fluazinam fungicide, is reducing by 30% pesticide total quantity The synergistic composition preparation of lower containing fluazinam still has good bactericidal activity to many plant disease pathogens.
Crop safety: using foliar spray method, is cucumber for studying object.Reagent agent is embodiment in above-mentioned preparation example 3,4 preparation, concentration for the treatment of setting is 20,40,80mg/L, separately sets the blank control for spraying clear water, 3 repetitions of every processing.Choosing The neat 2-3 leaf phase potting cucumber seedling of growth is selected, foliar spray processing is carried out by set concentration, dries, move to after chemicals treatment Normal management in greenhouse.Greenhouse experiment: 22-30 DEG C of temperature, humidity 40-60%.5d, 10d, 15d after spray are carried out respectively Investigation, the variation of the upgrowth situation of plant, especially growing point and newborn blade after observation sprays, including become caused by plant Phenomena such as color, necrosis, growth and development delay, wilt and is lopsided.And according to the occurrence degree of above-mentioned symptom, does and record and comment as follows Valence.
Attached phytotoxicity grade scale:
: plant strain growth is normal；
+: plant strain growth is slightly inhibited, or deformity or blade edge have and slightly burn；
++: plant strain growth is centainly inhibited, or deformity or blade have part to burn, but phenomenon can be restored；
+++: plant strain growth is suppressed, or deformity, or a large amount of blades are burnt, and phenomenon is difficult to restore；
++++: plant strain growth is heavily suppressed or severe deformities or plant it is withered.
Crop safety test: cucumber occurs without phytotoxicity under 20,40,80mg/L experimental concentration dosage, it is seen that implements To cucumber safety under example 3,4 experimental concentrations.It the results are shown in Table 2
Table 2: 3,4 pairs of cucumber safeties of embodiment
It is good to cucumber downy mildew (protectiveness) preventive effect that above-described embodiment 3,4 prepares preparation, and to cucumber safety.
Toxicity and crop safety test result show that acceptable salt closes sulfonic acid in fluazinam and agricultural production The synergistic composition of salt composition can be used in agricultural production preventing and treating the prevention and treatment of disease caused by egg bacteria, and synergistic effect is bright It is aobvious, especially there is special efficacy to cucumber downy mildew, watermelon epidemic disease, capsicum epidemic disease, the late blight of potato and downy mildew of garpe etc., meets and work as The harmonious development theory of preceding pesticide control total quantity emission reduction.
Meanwhile being mixed by above-mentioned each data are visible using two kinds of components specific in composition of the invention, also it can be improved To the control efficiency of crop disease, the dispersibility of active component can be improved, wetability improves suspensibility, enhancing penetration The characteristics of, active component is further penetrated into plant by blade surface layer；Also it improves simultaneously and target is made Object safety, with adhesive force and can rain wash resistance, and then the lasting period is long.

Claims (10)

1.一种杀菌组合物，其特征在于：组合物为A组分和B组分，按重量比为1-99：99-1混合；其中A组分为氟啶胺或氟啶胺农业上可接受的盐，B组分为磺酸盐类化合物。1. A bactericidal composition, characterized in that: the composition is composed of component A and component B, mixed in a weight ratio of 1-99:99-1; wherein component A is fluazinam or fluazinam Acceptable salt, component B is a sulfonate compound. 2.按权利要求1所述的杀菌组合物，其特征在于：所述A组为氟啶胺或氟啶胺农业上可接受的盐与羧酸吗啉类杀菌剂混合组成的混合物。2. The bactericidal composition according to claim 1, characterized in that: the group A is a mixture of fluazinam or an agriculturally acceptable salt of fluazinam and carboxylic acid morpholine fungicides. 3.按权利要求1或2所述的杀菌组合物，其特征在于：所述磺酸盐类化合物为C12～22烷烃磺酸、C8～12烷基苯磺酸、C8～12烷基苯磺酸的甲醛缩合物、甲酚磺酸的甲醛缩合物、α-C14～16烯烃磺酸、C8～12二烷基磺基琥珀酸、木质素磺酸、聚氧乙烯(单或二)C8～12烷基苯基醚磺酸、聚氧乙烯C12～18烷基醚磺基琥珀酸半酯、萘磺酸、(单或二)C1～6烷基萘磺酸、萘磺酸的甲醛缩合物、(单或二)C1～6烷基萘磺酸的甲醛缩合物、杂酚油磺酸的甲醛缩合物、C8～12烷基二苯基醚二磺酸、聚苯乙烯磺酸和苯乙烯磺酸与甲基丙烯酸的共聚物或上述磺酸的盐中的一种或几种。3. The bactericidal composition according to claim 1 or 2, characterized in that: the sulfonate compound is C 12-22 alkane sulfonic acid, C 8-12 alkylbenzene sulfonic acid, C 8-12 alkane Formaldehyde condensate of phenyl sulfonic acid, formaldehyde condensate of cresol sulfonic acid, α-C 14-16 olefin sulfonic acid, C 8-12 dialkyl sulfosuccinic acid, lignin sulfonic acid, polyoxyethylene (mono Or two) C 8～12 alkyl phenyl ether sulfonic acid, polyoxyethylene C 12～18 alkyl ether sulfosuccinic acid half ester, naphthalene sulfonic acid, (mono or di) C 1～6 alkyl naphthalene sulfonic acid , formaldehyde condensate of naphthalene sulfonic acid, formaldehyde condensate of (mono or di) C 1-6 alkylnaphthalene sulfonic acid, formaldehyde condensate of creosote sulfonic acid, C 8-12 alkyl diphenyl ether disulfonic acid Acid, polystyrene sulfonic acid, copolymer of styrene sulfonic acid and methacrylic acid, or one or more of the above-mentioned salts of sulfonic acid. 4.按权利要求3所述的杀菌组合物，其特征在于：所述磺酸盐类化合物为亚甲基双萘磺酸盐、十七烷基苯并咪唑磺酸盐、烷基苯磺酸盐、烷基萘磺酸盐、烷基磺酸盐、α-烯烃磺酸盐、α-磺基脂肪酸酯、内磺基脂肪酸酯、烷基磺基琥珀酸盐、脂肪酸羟乙基磺酸盐、酰甲胺烷烃磺酸盐、醚磺酸盐、木质素磺酸盐、石油磺酸盐中一种或几种。4. The sterilization composition according to claim 3, characterized by: sulfonate compounds are sulfonic acid synthesis, aslerate sulfonate, seventeen alkanezolzole sulfonate, alkylzide sulfonic acid Salt, alkyl sulfonate, alkylsulfonate, α-olefin sulfate, α-sulfonic fatty acid ester, endulfonic fatty acid ester, alkyl sulfonic acid salt, fatty acid hydroxyonal sulfonic sulfonic sulfa sulfon Avanic salt, sulfate, ether sulfonate, lignin sulfonate, and petroleum sulfonate. 5.一种权利要求1所述的杀菌组合物的应用，其特征在于：所述组合物在农业生产上防治由卵菌引起的农业病害中的应用。5. The application of the fungicidal composition according to claim 1, characterized in that: the composition is used in agricultural production to prevent and treat agricultural diseases caused by oomycetes. 6.一种按权利要求1所述的含杀菌组合物的制剂，其特征在于：制剂以杀菌组合物为活性组分,活性组分占制剂重量的5-70％。6. A preparation containing a bactericidal composition according to claim 1, characterized in that: the preparation uses the bactericidal composition as an active component, and the active component accounts for 5-70% of the weight of the preparation. 7.按权利要求6所述的制剂，其特征在于：所述制剂还包括助剂和/或辅助剂；其中，助剂为非离子助剂、崩解剂、粘结剂、载体、增稠剂中的一种或几种；辅助剂为防冻剂、消泡剂、防菌防霉剂、着色剂和盐中的一种或几种。7. The preparations according to claim 6 are characterized by: the preparation also includes the auxiliary and/or auxiliary agent; the auxiliary is a non -ionic aid, a disintegent, a bonding agent, a carrier, a thickest, a thickest One or more of the additives; the auxiliary agent is one or more of the antifreeze, defoamer, antibacterial and antifungal agent, colorant and salt. 8.按权利要求7所述的制剂，其特征在于：所述非离子助剂为聚乙二醇型表面活性剂、多元醇型表面活性剂、炔系表面活性剂、其它表面活性剂中的一种或几种。8. The preparations according to claim 7 are characterized by: the non -ionic auxiliary agent is a polyethylene glycol surfactant, a multi -alcohol -type surfactant, a tadpole surfactant, and other surface active agents One or more. 9.按权利要求6所述的制剂，其特征在于：所述制剂可制成悬浮剂、悬浮乳剂、可分散油悬浮剂、可湿性粉剂、水分散性颗粒剂、颗粒剂、片剂、微胶囊悬浮剂或微胶囊颗粒剂。9. according to the described preparation of claim 6, it is characterized in that: described preparation can be made into suspension concentrate, suspoemulsion, dispersible oil suspension concentrate, wettable powder, water dispersible granule, granule, tablet, microparticle Capsule floating agent or micro -capsule particle. 10.一种按权利要求6所述的含杀菌组合物的制剂的应用，其特征在于：所述制剂在农业生产上防治由卵菌引起的农业病害中的应用。10. An application of the preparation containing the bactericidal composition according to claim 6, characterized in that: the preparation is used in agricultural production to prevent and treat agricultural diseases caused by oomycetes.
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