CN109481558A

CN109481558A - Chinese medicine composition is preparing the application in fatigue proof drug

Info

Publication number: CN109481558A
Application number: CN201811559822.8A
Authority: CN
Inventors: 金兆祥; 王琳; 庞纪平; 张宇; 王玉晶; 范迪; 郭琳
Original assignee: Lerentang Pharmaceutical Factory of Tianjin Zhongxin Pharmaceutical Group Co Ltd
Current assignee: Lerentang Pharmaceutical Factory of Tianjin Zhongxin Pharmaceutical Group Co Ltd
Priority date: 2018-12-18
Filing date: 2018-12-18
Publication date: 2019-03-19

Abstract

The present invention provides a kind of Chinese medicine compositions to prepare the application in fatigue proof drug, is related to technical field of traditional Chinese medicines, and the present invention provides Chinese medicine compositions to prepare the application in fatigue proof drug.The Chinese medicine composition has significant curative effect as endurance drug.The drug is improving locomitivity, and slowing down has good effect in terms of sports fatigue, can be used as fatigue proof drug for clinical practice, to the drug make full use of and exploitation plays significance.Meanwhile the Chinese medicine derives from crude drug, is free from side effects, safely and effectively.

Description

Chinese medicine composition is preparing the application in fatigue proof drug

Technical field

The present invention relates to technical field of traditional Chinese medicines, more particularly, to a kind of Chinese medicine composition in preparing fatigue proof drug Using.

Background technique

Fatigue is a kind of sense of discomfort of subjectivity, is mainly shown as feeling of fatigue, taediumvitae, in progress long-time labour, acutely It can be perceived under movement or long-time stress, this is a kind of only normal physiological protection reaction, prompts body that should pass through Rest makes functional recovery, to avoid the further injury to body.However as the aggravation that society strives unexpectedly, rhythm of life adds Fastly, people are made usually to ignore fatigue, still selection works long hours.It is chronically at fatigue state, it can insulting physical strength, body Can, body is unbalance, makes one to be difficult to be engaged in or complete certain work larger or that movement is fine and smooth, exquisite that consume one's strength, to make work Make efficiency decline；On the other hand, chronic fatigue can also make one cutis laxa, and lusterless complexion shows prematurely senile sign；It is long Phase fatigue cannot be restored, and make human body immune system dysfunction, or even cause immunocompromised, the barrier quilt that body resists the disease Break, increases the probability of patient.In addition, long-term psychological pressure, hormone disturbance, dysimmunity etc., be cause it is chronic The main inducing of fatigue syndrome.The work of excess load, excessive pressure and irregular daily life system feel people usually It is difficult to restore for a long time to feeling of fatigue, taediumvitae, so that people is chronically at sub-health state, there are about 70% people to be in crowd This state, wherein again high-incidence with the middle-aged and the old.

Based on this, need to find antifatigue substance to delay to work for a long time, make under strenuous exercise or excessive stress At fatigue occur, or fatigue state is made to be restored to normal condition as early as possible, to make people's sub-health state restore normal or right Fatigue syndrome generates curative effect.

In view of this, the present invention is specifically proposed.

Summary of the invention

Of the invention is designed to provide Chinese medicine composition and is preparing the application in fatigue proof drug, at least to alleviate One of the technical problems existing in the prior art.

In order to realize above-mentioned purpose of the invention, the following technical scheme is adopted:

The present invention provides Chinese medicine compositions as described below to prepare the application in fatigue proof drug:

Dog kidney, deer's sinew take the lead mouth and remove pawl sparrow meat, donkey kidney, dried shrimps, pilose antler, hippocampus, extra large maggot, leopard bone processed, gekko, Ginseng, Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, radix aconiti lateralis preparata, cortex cinnamomi, Fructus Caryophylli, salt fennel, radix achyranthis bidentatae, salt psoralea corylifolia, Radix Codonopsis, Poria cocos, Chinese yam, charred CORTEX EUCOMMIAE, rhizoma cibotii, wine Herba Cistanches, walnut kernel, Herba Epimedii processed, salt fry semen astragali complanati, raspberry, fructus lycii, the wine five tastes Son, Semen Cuscutae, wine Fructus Corni (processed), calcined Dragon's bone and Radix Glycyrrhizae.

Further, effective dosage of the fatigue proof drug is 0.56~1.12mg/kg/ days.

Further, the urea nitrogen that the Chinese medicine composition is generated by reduction protein and/or hepatic glycogen aerobic metabolism Play the role of endurance.

Further, the Chinese medicine composition plays endurance work by reducing the lactic acid that glucose anerobic glycolysis generates With.

Further, the Chinese medicine composition includes: 1500-2500 parts of dog kidney, and 20-80 parts of deer's sinew, pilose antler 500-1200 Part, it takes the lead mouth and goes 5500-9500 parts of pawl sparrow meat, 750-1100 parts of donkey kidney, 300-900 parts of dried shrimps, hippocampus 100-1500 Part, extra large maggot 200-1000 parts, leopard bone 10-100 parts processed, 100-850 parts of gekko, 100-1200 parts of Radix Astragali, 300-1200 parts of ginseng, 300-1500 parts of Radix Angelicae Sinensis, 200-750 parts of cortex cinnamomi, 300-1200 parts of radix achyranthis bidentatae, 1500-4500 parts of Fructus Caryophylli, Rehmannia glutinosa 3000-6000 Part, 3500-7000 parts of radix aconiti lateralis preparata, 950-1800 parts of salt fennel, 700-1700 parts of salt psoralea corylifolia, 1200-3000 parts of Radix Codonopsis, 100-1500 parts of rhizoma cibotii, 500-1500 parts of Poria cocos, 950-2500 parts of Chinese yam, 900-1700 parts of walnut kernel, charred CORTEX EUCOMMIAE 300-1200 Part, 3000-6500 parts of wine Herba Cistanches, Herba Epimedii 900-3500 parts processed, salt fries semen astragali complanati 900-1700 parts, Radix Glycyrrhizae 100-900 Part, 1000-3000 parts of raspberry, 600-1700 parts of Semen Cuscutae, 500-1500 parts of fructus lycii, 250-1500 parts of calcined Dragon's bone, wine system 300-1200 parts and 500-1800 parts of wine Fructus Corni (processed) of Schisandra chinensis.

Further, the Chinese medicine composition includes: 1600-2200 parts of dog kidney, and 30-70 parts of deer's sinew, pilose antler 600-1000 Part, it takes the lead mouth and goes 6000-8000 parts of pawl sparrow meat, 800-1000 parts of donkey kidney, 400-800 parts of dried shrimps, hippocampus 200-1200 Part, extra large maggot 250-800 parts, leopard bone 20-80 parts processed, 200-600 parts of gekko, 200-1000 parts of Radix Astragali, 400-1000 parts of ginseng, when Return 500-1200 parts, 250-600 parts of cortex cinnamomi, 400-1000 parts of radix achyranthis bidentatae, 2000-3000 parts of Fructus Caryophylli, Rehmannia glutinosa 4000-5500 Part, 4000-6000 parts of radix aconiti lateralis preparata, 1000-1600 parts of salt fennel, 800-1500 parts of salt psoralea corylifolia, Radix Codonopsis 1300-2800 Part, 200-1200 parts of rhizoma cibotii, 600-1200 parts of Poria cocos, 1000-2000 parts of Chinese yam, 1000-1500 parts of walnut kernel, charred CORTEX EUCOMMIAE 400- 1000 parts, 4000-6000 parts of wine Herba Cistanches, Herba Epimedii 1000-3000 parts processed, salt fries semen astragali complanati 1000-1500 parts, Radix Glycyrrhizae 200-800 parts, 1200-2800 parts of raspberry, 800-1500 parts of Semen Cuscutae, 600-1300 parts of fructus lycii, calcined Dragon's bone 450-1200 Part, 400-1000 parts and 600-1600 parts of wine Fructus Corni (processed) of wine Fructus Schisandrae (processed).

Further, the drug of the fatigue further includes pharmaceutically acceptable auxiliary material.

Further, the dosage form of the drug of the fatigue includes oral preparation or ejection preparation.

Further, the oral preparation includes tablet, capsule, granule, pill, syrup, oral solution, mouth Take suspension or Orally taken emulsion.

Further, the ejection preparation includes injection or powder-injection.

The present invention provides Chinese medicine compositions to prepare the application in fatigue proof drug.The Chinese medicine composition includes dog Kidney, deer's sinew take the lead mouth and remove pawl sparrow meat, donkey kidney, dried shrimps, pilose antler, hippocampus, extra large maggot, leopard bone processed, gekko, ginseng, Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, radix aconiti lateralis preparata, cortex cinnamomi, Fructus Caryophylli, salt fennel, radix achyranthis bidentatae, salt psoralea corylifolia, Radix Codonopsis, Poria cocos, Chinese yam, Cortex Eucommiae Charcoal, rhizoma cibotii, wine Herba Cistanches, walnut kernel, Herba Epimedii processed, salt stir-fry semen astragali complanati, raspberry, fructus lycii, wine Fructus Schisandrae (processed), Tu Son, wine Fructus Corni (processed), calcined Dragon's bone and Radix Glycyrrhizae have significant curative effect as endurance drug.The drug is improving movement energy Power has good effect in terms of slowing down sports fatigue, can be used as fatigue proof drug for clinical practice, to the drug It makes full use of and exploitation plays significance.Meanwhile the Chinese medicine derives from crude drug, is free from side effects, has safely Effect.

Detailed description of the invention

It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art Embodiment or attached drawing needed to be used in the description of the prior art be briefly described, it should be apparent that, it is described below Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor It puts, is also possible to obtain other drawings based on these drawings.

Fig. 1 is the result figure that the Chinese medicine composition that the embodiment of the present invention 2 provides influences tired rat swimming time；

Fig. 2 is the result figure that the Chinese medicine composition that the embodiment of the present invention 2 provides influences tired rat BUN, LD；

Fig. 3 is the result figure that the Chinese medicine composition that the embodiment of the present invention 2 provides influences tired rat hepatic glycogen.

Specific embodiment

Technical solution of the present invention is clearly and completely described below in conjunction with embodiment, it is clear that described reality Applying example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, the common skill in this field Art personnel every other embodiment obtained without making creative work belongs to the model that the present invention protects It encloses.

According to an aspect of the invention, there is provided Chinese medicine composition as described below is in preparing fatigue proof drug Using:

Chinese medicine composition of the present invention is currently used primarily in the effect of enriching yin and nourishing kidney, strong brain tonic, declines for body Weak, qi-blood deficiency, deficiency of kidney-QI is lean and haggard, heartbeat shortness of breath, soreness of waist and ache in legs, the illnesss such as amnesia void asthma.The present invention in order to make on Stating Chinese medicine composition can be fully utilized, by the discovery of the experimental study creativeness Chinese medicine composition as endurance Drug has significant curative effect.The drug is improving locomitivity, has good effect, Ke Yizuo in terms of slowing down sports fatigue For fatigue proof drug be used for clinical practice, to the drug make full use of and exploitation plays significance.Meanwhile the Chinese medicine Medicament sources are free from side effects in crude drug, safely and effectively.

In some preferred embodiments, effective dosage of the fatigue proof drug is 0.56~1.12mg/ Kg/ days, such as can be, but be not limited to 0.56mg/kg/ days, 0.6mg/kg/ days, 0.65mg/kg/ days, 0.7mg/kg/ days, 0.75mg/kg/ days, 0.8mg/kg/ days, 0.85mg/kg/ days, 0.9mg/kg/ days, 0.95mg/kg/ days, 1mg/kg/ days, 1.05mg/kg/ days, 1.1mg/kg/ days or 1.12mg/kg/ days.

In some preferred embodiments, administration frequency for example can be, but be not limited to twice daily, once a day, Once every two days, once-weekly or once-monthly administration.Alternatively, medicine provided by the invention can be given in the form of sustained release preparation Object, in this case it is necessary to less administration frequency.

Dosage and frequency are different in drug user's intracorporal half-life period according to preparation, in addition it is also possible to according to being pre- The processing of anti-property or therapeutic treatment and it is different.In prophylactic use, given for a long time with the interval of rather low-frequency rate relatively low Dosage.In therapeutic application, it is sometimes desirable to relatively high dosage is given with relatively short interval, until the progress quilt of disease Delay or stop, and is preferably up to the individual partially or completely improvement for showing disease symptoms to give and suffer from after this Person's prevention scheme.

In some preferred embodiments, the Chinese medicine composition has oxo by reducing protein and/or hepatic glycogen The urea nitrogen for thanking to generation plays the role of endurance.

In other preferred embodiments, the Chinese medicine composition, which passes through, reduces the cream that glucose anerobic glycolysis generates Acid plays the role of endurance.

In some preferred embodiments, the Chinese medicine composition includes: 1500-2500 parts of dog kidney, such as can be, But it is not limited to 1500 parts, 1800 parts, 2000 parts, 2200 parts or 2500 parts；20-80 parts of deer's sinew, such as can be, but be not limited to 20 Part, 30 parts, 40 parts, 50 parts, 60 parts, 70 parts or 80 parts；500-1200 parts of pilose antler, such as can be, but be not limited to 500 parts, 800 Part, 1000 parts or 1200 parts；Take the lead mouth and go 5500-9500 parts of pawl sparrow meat, such as can be, but be not limited to 5500 parts, 6000 parts, 6500 parts, 7000 parts, 7500 parts, 8000 parts, 8500 parts, 9000 parts or 9500 parts；750-1100 parts of donkey kidney, such as It can be, but be not limited to 750 parts, 800 parts, 900 parts, 1000 parts or 1100 parts；300-900 parts of dried shrimps, such as can be, but It is not limited to 300 parts, 400 parts, 500 parts, 600 parts, 700 parts, 800 parts or 900 parts；100-1500 parts of hippocampus, such as can be, but It is not limited to 100 parts, 300 parts, 500 parts, 800 parts, 1000 parts, 1200 parts or 1500 parts；Extra large maggot 200-1000 parts, such as can be with For, but it is not limited to 200 parts, 400 parts, 600 parts, 800 parts or 1000 parts；Leopard bone 10-100 parts processed, such as can be, but be not limited to 10 parts, 20 parts, 30 parts, 40 parts, 50 parts, 60 parts, 70 parts, 80 parts, 90 parts or 100 parts；100-850 parts of gekko, such as can be, But it is not limited to 100 parts, 200 parts, 300 parts, 400 parts, 500 parts, 600 parts, 700 parts, 800 parts or 850 parts；Radix Astragali 100-1200 Part, such as can be, but be not limited to 100 parts, 300 parts, 500 parts, 800 parts, 1000 parts or 1200 parts；300-1200 parts of ginseng, Such as can be, but be not limited to 300 parts, 500 parts, 800 parts, 1000 parts or 1200 parts；300-1500 parts of Radix Angelicae Sinensis, such as can be with For, but it is not limited to 300 parts, 500 parts, 800 parts, 1000 parts, 1200 parts or 1500 parts；200-750 parts of cortex cinnamomi, such as can be, But it is not limited to 200 parts, 500 parts, 700 parts or 750 parts；300-1200 parts of radix achyranthis bidentatae, such as can be, but be not limited to 300 parts, 500 Part, 800 parts, 1000 parts or 1200 parts；1500-4500 parts of Fructus Caryophylli, such as can be, but be not limited to 1500 parts, 2000 parts, 2500 parts, 3000 parts, 3500 parts, 4000 parts or 4500 parts；3000-6000 parts of Rehmannia glutinosa, such as can be, but be not limited to 3000 Part, 4000 parts, 5000 parts or 6000 parts；3500-7000 parts of radix aconiti lateralis preparata, such as can be, but be not limited to 3500 parts, 4000 parts, 5000 parts, 6000 parts or 7000 parts；950-1800 parts of salt fennel, such as can be, but be not limited to 950 parts, 1200 parts, 1500 Part, 1600 parts or 1800 parts；700-1700 parts of salt psoralea corylifolia, such as can be, but be not limited to 700 parts, 1000 parts, 1200 Part, 1500 parts or 1700 parts；1200-3000 parts of Radix Codonopsis, such as can be, but be not limited to 1200 parts, 1500 parts, 1800 parts, 2000 parts, 2200 parts, 2500 parts, 2800 parts or 3000 parts；100-1500 parts of rhizoma cibotii, such as can be, but be not limited to 100 parts, 300 parts, 500 parts, 800 parts, 1000 parts, 1200 parts or 1500 parts；500-1500 parts of Poria cocos, such as can be, but be not limited to 500 Part, 800 parts, 1000 parts, 1200 parts or 1500 parts；950-2500 parts of Chinese yam, such as can be, but be not limited to 950 parts, 1200 Part, 1500 parts, 1800 parts, 2000 parts, 2200 parts or 2500 parts；900-1700 parts of walnut kernel, such as can be, but be not limited to 900 parts, 1000 parts, 1200 parts, 1500 parts or 1700 parts；300-1200 parts of charred CORTEX EUCOMMIAE, such as can be, but be not limited to 300 parts, 500 parts, 800 parts, 1000 parts or 1200 parts；3000-6500 parts of wine Herba Cistanches, such as can be, but be not limited to 3000 parts, 4000 parts, 5000 parts, 6000 parts or 6500 parts；Herba Epimedii 900-3500 parts processed, such as can be, but be not limited to 900 parts, 1200 Part, 1500 parts, 1800 parts, 2000 parts, 2200 parts, 2500 parts, 2800 parts, 3000 parts, 3200 parts or 3500 parts；Salt fries semen astragali complanati 900-1700 parts, such as can be, but be not limited to 900 parts, 1000 parts, 1200 parts, 1500 parts or 1700 parts；Radix Glycyrrhizae 100-900 Part, such as can be, but be not limited to 100 parts, 200 parts, 500 parts, 600 parts, 800 parts or 900 parts；1000-3000 parts of raspberry, Such as can be, but be not limited to 1000 parts, 2000 parts or 3000 parts；600-1700 parts of Semen Cuscutae, such as can be, but be not limited to 600 parts, 800 parts, 1000 parts, 1200 parts, 1500 parts or 1800 parts；500-1500 parts of fructus lycii, such as can be, but be not limited to 500 parts, 800 parts, 1000 parts, 1200 parts or 1500 parts；250-1500 parts of calcined Dragon's bone, such as can be, but be not limited to 250 parts, 400 parts, 500 parts, 800 parts, 1000 parts, 1200 parts or 1500 parts；300-1200 parts of wine Fructus Schisandrae (processed), such as can be, but not It is limited to 300 parts, 500 parts, 800 parts, 1000 parts or 1200 parts；500-1800 parts of wine Fructus Corni (processed), such as can be, but be not limited to 500 parts, 800 parts, 1000 parts, 1200 parts, 1500 parts or 1800 parts.

In some preferred embodiments, the Chinese medicine composition includes: 1600-2200 parts of dog kidney, deer's sinew 30-70 Part, it 600-1000 parts of pilose antler, takes the lead mouth and goes 6000-8000 parts of pawl sparrow meat, 800-1000 parts of donkey kidney, dried shrimps 400-800 Part, 200-1200 parts of hippocampus, extra large maggot 250-800 parts, leopard bone 20-80 parts processed, 200-600 parts of gekko, 200-1000 parts of Radix Astragali, people 400-1000 parts of ginseng, it is 500-1200 parts of Radix Angelicae Sinensis, 250-600 parts of cortex cinnamomi, 400-1000 parts of radix achyranthis bidentatae, 2000-3000 parts of Fructus Caryophylli, ripe 4000-5500 parts of glutinous rehmannia, 4000-6000 parts of radix aconiti lateralis preparata, 1000-1600 parts of salt fennel, 800-1500 parts of salt psoralea corylifolia, party 1300-2800 parts of ginseng, 200-1200 parts of rhizoma cibotii, 600-1200 parts of Poria cocos, 1000-2000 parts of Chinese yam, walnut kernel 1000-1500 Part, 400-1000 parts of charred CORTEX EUCOMMIAE, 4000-6000 parts of wine Herba Cistanches, Herba Epimedii 1000-3000 parts processed, salt fries semen astragali complanati 1000- 1500 parts, 200-800 parts of Radix Glycyrrhizae, 1200-2800 parts of raspberry, 800-1500 parts of Semen Cuscutae, 600-1300 parts of fructus lycii, forge dragon 450-1200 parts of bone, 400-1000 parts and 600-1600 parts of wine Fructus Corni (processed) of wine Fructus Schisandrae (processed).

In some preferred embodiments, the drug of the fatigue further includes pharmaceutically acceptable auxiliary material.

When pharmaceutically acceptable auxiliary material refers to production drug and prescription being dispensed, the excipient and additives used is Refer in addition to the active ingredient (s, reasonable assessment is had been carried out in terms of safety, and include the substance in pharmaceutical preparation.It is same Pharmaceutic adjuvant can be used for the pharmaceutical preparation of different way of administration, and play the role of different and purposes.In drug provided by the invention The pharmaceutically acceptable auxiliary material of middle addition can play the role of excipient, serve as carrier or improve stability, in addition, also having There are the critical functions such as solubilising, hydrotropy or slow controlled release.

Typical but non-limiting pharmaceutically acceptable auxiliary material includes: solvent, propellant, solubilizer, cosolvent, emulsification Agent, colorant, binder, disintegrating agent, filler, lubricant, wetting agent, osmotic pressure regulator, stabilizer, glidant, flavoring Agent, preservative, suspending agent, coating material, aromatic, anti stickness agent, antioxidant, chelating agent, penetration enhancer, pH adjusting agent, Buffer, plasticizer, surfactant, foaming agent, defoaming agent, thickener, inclusion agents, moisturizer, absorbent, diluent, wadding One of solidifying agent and deflocculant, filter aid or release retarding agent are a variety of.

In one preferred embodiment, the dosage form of drug includes oral preparation or ejection preparation.

When oral medication, said medicine can be made into and arbitrarily take orally acceptable dosage form, such as can be, but unlimited In tablet, capsule, granule, pill, syrup, oral solution, oral suspensions or Orally taken emulsion.

Wherein, the carrier that tablet uses generally comprises lactose and cornstarch, and lubricant such as stearic acid in addition can also be added Magnesium.The diluent that capsule uses generally comprises lactose and dried corn starch.Oral suspensions are then usually by active constituent It is used in mixed way with suitable emulsifier and suspending agent.

Optionally, some sweeteners, aromatic or colorant can also be added in the above oral dosage form.

When being administered in the form of injection, said medicine can be made into the acceptable dosage form of any injection, such as can be with For, but it is not limited to injection or powder-injection.

Wherein, workable carrier and solvent include water, Ringer's solution and isotonic sodium chlorrde solution.In addition, sterilizing Fixed oil also is used as solvent or suspension media, such as monoglyceride or two glyceride.

In order to facilitate it is clearer understand the contents of the present invention, be described in detail as follows now in conjunction with specific embodiment.

Unless otherwise instructed, cell, drug used in the embodiment of the present invention and the equal source of reagent are regular and easily purchase canal Road:

Guilingji capsules capsule: 0.3g/, lot number 103170408, Shanxi Guang Yuyuan traditional Chinese medicines Co., Ltd；The different sorb of single nitric acid Ester piece: lot number 07160204, Lunan Beite Pharmaceutical Co., Ltd.；Lactic acid testing cassete: lot number 20180315, Nanjing is built up；Liver/flesh Glycogen kit: lot number 20180314, Nanjing is built up；Urea nitrogen: lot number 20180313, Nanjing is built up；SD rat, ICR mouse: SPF grades, Beijing Vital River Experimental Animals Technology Co., Ltd., credit number: SCXK (capital) 2016-0006.

The preparation of 1 Chinese medicine composition of embodiment

In the present embodiment, the Chinese medicine composition is made by the steps:

(a) 750 parts of charred CORTEX EUCOMMIAEs are crushed into powder, it is spare crosses 120 meshes；

(b) 5000 parts of Rehmannia glutinosas and 7500 parts are taken the lead to boil before the water that mouth goes pawl sparrow meat to add 8 times of weight 8 times, every time It boils 3 hours, merges decocting liquid, filtration, the condensed cream that it is 1.5 in 50 DEG C of relative densities that filtrate, which is condensed into,；

(c) 4000 times of weight yellow rice wine are added to set container 930 parts of donkey kidneys, 1875 parts of dog kidneys, 40 parts of deer's sinews and 500 parts of dried shrimps Interior, sealing is steamed until yellow rice wine is exhausted by medicinal material, is taken out, be dry, pulverize sieving；

(d) by remaining 29 taste raw material (750 parts of pilose antler, 75 parts of hippocampus 3,375 parts of extra large maggot, 40 parts of leopard bone processed, 240 parts of gekko, 750 parts of ginseng, 625 parts of Radix Astragali, 1000 parts of Radix Angelicae Sinensis, 5000 parts of radix aconiti lateralis preparata, 375 parts of cortex cinnamomi, 2500 parts of Fructus Caryophylli, salt fennel 1250 parts, 750 parts of radix achyranthis bidentatae, 1250 parts of salt psoralea corylifolia, 1875 parts of Radix Codonopsis, 750 parts of Poria cocos, 1500 parts of Chinese yam, 375 parts of rhizoma cibotii, 5000 parts of wine Herba Cistanches, 1250 parts of walnut kernel, 2000 parts of Herba Epimedii processed, 1250 parts of semen astragali complanati of salt stir-fry, 2000 parts of raspberry, Chinese holly 750 parts of matrimony vine, 750 parts of wine Fructus Schisandrae (processed), 1250 parts of Semen Cuscutae, 750 parts of wine Fructus Corni (processed), 625 parts of calcined Dragon's bone and Radix Glycyrrhizae 375 Part) pulverize and sieve；Powder made from step (c) is added, condensed cream made from step (b) is added, proper honey and water, system is added Ball rushes circle, dry, is coated with step (a) Cortex Eucommiae powdered carbon, polishing, dry to get the Chinese medicine composition, spare.

2 Chinese medicine composition of embodiment is on fatigue proof influence

Select healthy male SD rat, SPF grades, weight (180-200) g, after rat adaptive feeding 3d, by weight with Machine grouping, every group 10, experiment sets Normal group, model control group, Isosorbide Mononitrate piece 20mg/kg, guilingji capsules 0.12g/kg, Chinese medicine composition (0.28,0.56,1.12) tri- dosage groups of g/kg, totally 7 groups.Each daily gastric infusion 1 of administration group Secondary, Normal group gives the distilled water of equivalent, and model control group is given corresponding volume 0.5%CMC-Na, continuous 14 days, is administered Volume is 10ml/kg.bw.

Experiment first day, in addition to Normal group, remaining each group rat is put into adaptability in plastic barrel and swims, the depth of water 20cm, water temperature (24 ± 2) DEG C, one time a day, each 20min, for three days on end.Then begin to formal swimming instruction in 9 days, daily into 2 swimming instructions of row, time are 20min/ times.When there is harmony during individual rats'swimmings and being decreased obviously, sink repeatedly It takes out.Once not moved it was found that animal is kept afloat, is driven with wooden stick and it is forced to maintain motion state.The 13rd day is tested, each group Swim after gastric infusion 1h 15min respectively, and orbital vein takes blood, and serum is for measuring urea nitrogen (BUN) and lactic acid (LD)；Experiment 14th day, 1h progress power exhausted swimming test after each group is administered respectively, recorded rat from the time for starting to swim to sinking repeatedly. It after the anesthesia of 40mg/kg yellow Jackets, takes lobus dexter part hepatic tissue to enter -80 DEG C of refrigerators and saves backup, for measuring hepatic glycogen, tie Fruit sees Tables 1 and 2, Fig. 1-3.

1 Chinese medicine composition of table tired rat swimming time is influenced (N=10)

Compared with Normal group, P < 0.05 △；P < 0.01 , ﹡ P < 0.05, * * compared with model group；N: number of animals.

From table 1 it follows that model control group swimming time significantly shortens compared with Normal group, display has been made At Tiredness model.Compared with model control group, Chinese medicine composition 1.12g/kg and 0.56g/kg dosage group can prolong to some extent Long rat swimming time, guilingji capsules 0.12g/kg can equally extend rat swimming time, the different mountain of positive drug single nitric acid Pear ester has no remarkable effect.

2 Chinese medicine composition of table to tired rat BUN, LD, hepatic glycogen influence (N=10)

From Table 2, it can be seen that model control group hepatic glycogen content significantly reduces compared with Normal group, in serum BUN, LD are dramatically increased.Compared with model control group, Chinese medicine composition 1.12g/kg, 0.56g/kg can reduce blood to some extent BUN, LD content in clear reduce hepatic glycogen consumption.Guilingji capsules 0.12g/kg effect is similar, and positive drug Isosorbide Mononitrate has no Remarkable effect.

By the analysis and summary to the present embodiment result, Chinese medicine composition provided by the invention by reduce protein, The lactic acid that the urea nitrogen and glucose anerobic glycolysis that hepatic glycogen aerobic metabolism generates generate, improves locomitivity, it is tired to slow down movement Labor.

Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent Pipe present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: its according to So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into Row equivalent replacement；And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution The range of scheme.

Claims

1. Chinese medicine composition as described below is preparing the application in fatigue proof drug:

Dog kidney, deer's sinew take the lead mouth and remove pawl sparrow meat, donkey kidney, dried shrimps, pilose antler, hippocampus, extra large maggot, leopard bone processed, gekko, ginseng, Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, radix aconiti lateralis preparata, cortex cinnamomi, Fructus Caryophylli, salt fennel, radix achyranthis bidentatae, salt psoralea corylifolia, Radix Codonopsis, Poria cocos, Chinese yam, Charred CORTEX EUCOMMIAE, rhizoma cibotii, wine Herba Cistanches, walnut kernel, Herba Epimedii processed, salt fry semen astragali complanati, raspberry, fructus lycii, wine Fructus Schisandrae (processed), Tu Silk, wine Fructus Corni (processed), calcined Dragon's bone and Radix Glycyrrhizae.

2. application according to claim 1, which is characterized in that effective dosage of the fatigue proof drug is 0.56 ~1.12mg/kg/ days.

3. application according to claim 1, which is characterized in that the Chinese medicine composition is by reducing protein and/or liver The urea nitrogen that glycogen aerobic metabolism generates plays the role of endurance.

4. application according to claim 1, which is characterized in that the Chinese medicine composition is by reducing glucose anerobic glycolysis The lactic acid of generation plays the role of endurance.

5. application according to claim 1, which is characterized in that the Chinese medicine composition includes: 1500-2500 parts of dog kidney, It 20-80 parts of deer's sinew, 500-1200 parts of pilose antler, takes the lead mouth and goes 5500-9500 parts of pawl sparrow meat, 750-1100 parts of donkey kidney, do sea 300-900 parts of rice, 100-1500 parts of hippocampus, extra large maggot 200-1000 parts, leopard bone 10-100 parts processed, 100-850 parts of gekko, Radix Astragali 100-1200 parts, 300-1200 parts of ginseng, 300-1500 parts of Radix Angelicae Sinensis, 200-750 parts of cortex cinnamomi, 300-1200 parts of radix achyranthis bidentatae, Fructus Caryophylli 1500-4500 parts, 3000-6000 parts of Rehmannia glutinosa, 3500-7000 parts of radix aconiti lateralis preparata, 950-1800 parts of salt fennel, salt psoralea corylifolia 700-1700 parts, 1200-3000 parts of Radix Codonopsis, 100-1500 parts of rhizoma cibotii, 500-1500 parts of Poria cocos, 950-2500 parts of Chinese yam, walnut 900-1700 parts of benevolence, 300-1200 parts of charred CORTEX EUCOMMIAE, 3000-6500 parts of wine Herba Cistanches, Herba Epimedii 900-3500 parts processed, salt is fried husky Garden is 900-1700 parts sub-, and 100-900 parts of Radix Glycyrrhizae, 1000-3000 parts of raspberry, 600-1700 parts of Semen Cuscutae, fructus lycii 500- 1500 parts, 250-1500 parts of calcined Dragon's bone, 300-1200 parts and 500-1800 parts of wine Fructus Corni (processed) of wine Fructus Schisandrae (processed).

6. application according to claim 5, which is characterized in that the Chinese medicine composition includes: 1600-2200 parts of dog kidney, It 30-70 parts of deer's sinew, 600-1000 parts of pilose antler, takes the lead mouth and goes 6000-8000 parts of pawl sparrow meat, 800-1000 parts of donkey kidney, do sea 400-800 parts of rice, 200-1200 parts of hippocampus, extra large maggot 250-800 parts, leopard bone 20-80 parts processed, 200-600 parts of gekko, Radix Astragali 200- 1000 parts, 400-1000 parts of ginseng, 500-1200 parts of Radix Angelicae Sinensis, 250-600 parts of cortex cinnamomi, 400-1000 parts of radix achyranthis bidentatae, Fructus Caryophylli 2000- 3000 parts, 4000-5500 parts of Rehmannia glutinosa, 4000-6000 parts of radix aconiti lateralis preparata, 1000-1600 parts of salt fennel, salt psoralea corylifolia 800- 1500 parts, 1300-2800 parts of Radix Codonopsis, 200-1200 parts of rhizoma cibotii, 600-1200 parts of Poria cocos, 1000-2000 parts of Chinese yam, walnut kernel 1000-1500 parts, 400-1000 parts of charred CORTEX EUCOMMIAE, 4000-6000 parts of wine Herba Cistanches, Herba Epimedii 1000-3000 parts processed, salt is fried husky Garden is 1000-1500 parts sub-, and 200-800 parts of Radix Glycyrrhizae, 1200-2800 parts of raspberry, 800-1500 parts of Semen Cuscutae, fructus lycii 600- 1300 parts, 450-1200 parts of calcined Dragon's bone, 400-1000 parts and 600-1600 parts of wine Fructus Corni (processed) of wine Fructus Schisandrae (processed).

7. application according to claim 1, which is characterized in that the drug of the fatigue further includes pharmaceutically acceptable auxiliary Material.

8. application according to claim 1, which is characterized in that the dosage form of the drug of the fatigue includes oral preparation or note Penetrate preparation.

9. application according to claim 8, which is characterized in that the oral preparation include tablet, capsule, granule, Pill, syrup, oral solution, oral suspensions or Orally taken emulsion.

10. application according to claim 8, which is characterized in that the ejection preparation includes injection or powder-injection.