CN109362797A - Iodine disinfectant and preparation method thereof - Google Patents
Iodine disinfectant and preparation method thereof Download PDFInfo
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- CN109362797A CN109362797A CN201811472650.0A CN201811472650A CN109362797A CN 109362797 A CN109362797 A CN 109362797A CN 201811472650 A CN201811472650 A CN 201811472650A CN 109362797 A CN109362797 A CN 109362797A
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- iodine
- mass percentage
- iodine disinfectant
- chinese medicine
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- 229910052740 iodine Inorganic materials 0.000 title claims abstract description 42
- 239000011630 iodine Substances 0.000 title claims abstract description 42
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000000645 desinfectant Substances 0.000 title claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 40
- 239000003814 drug Substances 0.000 claims abstract description 28
- 239000000203 mixture Substances 0.000 claims abstract description 28
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 26
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 26
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000006184 cosolvent Substances 0.000 claims abstract description 17
- 239000003381 stabilizer Substances 0.000 claims abstract description 13
- 239000003002 pH adjusting agent Substances 0.000 claims abstract description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 33
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 21
- 241000205585 Aquilegia canadensis Species 0.000 claims description 15
- 241000245665 Taraxacum Species 0.000 claims description 14
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims description 14
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 239000001508 potassium citrate Substances 0.000 claims description 9
- 229960002635 potassium citrate Drugs 0.000 claims description 9
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 9
- 235000011082 potassium citrates Nutrition 0.000 claims description 9
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 claims description 9
- 239000000469 ethanolic extract Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 4
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 3
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 3
- JLKDVMWYMMLWTI-UHFFFAOYSA-M potassium iodate Chemical compound [K+].[O-]I(=O)=O JLKDVMWYMMLWTI-UHFFFAOYSA-M 0.000 claims description 3
- 239000001230 potassium iodate Substances 0.000 claims description 3
- 235000006666 potassium iodate Nutrition 0.000 claims description 3
- 229940093930 potassium iodate Drugs 0.000 claims description 3
- 235000007715 potassium iodide Nutrition 0.000 claims description 3
- 239000001509 sodium citrate Substances 0.000 claims description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 3
- 235000009518 sodium iodide Nutrition 0.000 claims description 3
- 235000015165 citric acid Nutrition 0.000 claims description 2
- -1 polyoxyethylene octylphenol Polymers 0.000 claims description 2
- 235000011083 sodium citrates Nutrition 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims 8
- 239000011259 mixed solution Substances 0.000 claims 4
- 241000555712 Forsythia Species 0.000 claims 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 230000000249 desinfective effect Effects 0.000 abstract description 29
- 239000007788 liquid Substances 0.000 abstract description 28
- 235000019441 ethanol Nutrition 0.000 abstract description 19
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 abstract description 12
- 229940033663 thimerosal Drugs 0.000 abstract description 12
- LRMHFDNWKCSEQU-UHFFFAOYSA-N ethoxyethane;phenol Chemical compound CCOCC.OC1=CC=CC=C1 LRMHFDNWKCSEQU-UHFFFAOYSA-N 0.000 abstract description 6
- 230000000855 fungicidal effect Effects 0.000 abstract description 4
- 239000004615 ingredient Substances 0.000 abstract description 3
- 238000003756 stirring Methods 0.000 description 15
- 230000001954 sterilising effect Effects 0.000 description 14
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 13
- 239000008367 deionised water Substances 0.000 description 10
- 229910021641 deionized water Inorganic materials 0.000 description 10
- 230000000694 effects Effects 0.000 description 10
- 238000004659 sterilization and disinfection Methods 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 9
- 241000193830 Bacillus <bacterium> Species 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 241000588724 Escherichia coli Species 0.000 description 5
- 241000191967 Staphylococcus aureus Species 0.000 description 5
- 238000004321 preservation Methods 0.000 description 5
- 238000004445 quantitative analysis Methods 0.000 description 5
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 150000002496 iodine Chemical class 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 230000002195 synergetic effect Effects 0.000 description 4
- 241000222122 Candida albicans Species 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- 208000037386 Typhoid Diseases 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 230000033228 biological regulation Effects 0.000 description 3
- 229940095731 candida albicans Drugs 0.000 description 3
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 201000008297 typhoid fever Diseases 0.000 description 3
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 229910017053 inorganic salt Inorganic materials 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000588832 Bordetella pertussis Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 241000607764 Shigella dysenteriae Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 230000001716 anti-fugal effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- TWOWSRSKGJSZHZ-VRHDFFKNSA-N bouvardin Chemical compound C1=CC(OC)=CC=C1C[C@H](N(C)C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](N(C1=O)C)C2)C(=O)N[C@@H](C)C(=O)N(C)[C@H]1[C@@H](O)C(C=C1)=CC=C1OC1=CC2=CC=C1O TWOWSRSKGJSZHZ-VRHDFFKNSA-N 0.000 description 1
- BNOCDYMCAVSRBT-UHFFFAOYSA-N bouvardin Natural products COc1ccc(CC2N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C3Cc4ccc(O)c(Oc5cccc(c5)C(O)C(N(C)C(=O)C(C)NC2=O)C(=O)N3C)c4)cc1 BNOCDYMCAVSRBT-UHFFFAOYSA-N 0.000 description 1
- 108010047824 bouvardin Proteins 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 125000005909 ethyl alcohol group Chemical group 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229960003975 potassium Drugs 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229940007046 shigella dysenteriae Drugs 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
- A01N31/14—Ethers
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/12—Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Microbiology (AREA)
- Pest Control & Pesticides (AREA)
- Botany (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
This application involves a kind of iodic disinfecting liquids and preparation method thereof, wherein iodic disinfecting liquid includes the iodine of 1.5%~3.5% mass percentage, the cosolvent of 0.5%~1.5% mass percentage, the ethyl alcohol of 40%~50% mass percentage, the polyoxethylene octylphenyl phenol ether -10 (OP-10) of 1.0%~2.0% mass percentage, the polyvinylpyrrolidone (PVP) of 4.5%~5.5% mass percentage, the Chinese medicine composition of 4.0%~6.0% mass percentage, the pH adjusting agent of 0.5%~1.5% mass percentage, the stabilizer of 4.5%~5.5% mass percentage and the water of surplus.Above-mentioned iodic disinfecting liquid is effectively sterilized iodine number and is increased, and it is the thimerosal that a kind of fungicidal effectiveness is strong, highly-safe, stability is good that increased Chinese medicinal ingredients, which also cooperate with and improve fungicidal effectiveness,.
Description
Technical field
The present invention relates to disinfectant technical fields, more particularly to a kind of iodic disinfecting liquid and preparation method thereof.
Background technique
Iodine class thimerosal is with iodine for main sterilization component and manufactured various preparations, due to sterilization spectrum, disinfection
The advantages that effect is good, sterilization scope have been directed to the fields such as clinic, daily life, animal husbandry and fishery cultivation and drinking water.But iodine
Dissolubility is poor in water there are iodine for class thimerosal, easily distils, the disadvantages of being not sufficiently stable, limits the development of iodine class thimerosal always
And application.Further investigation with scientific research personnel to iodine class thimerosal, many Experiment Results are applied in the industrial production,
Although improving the solubility of iodine, sterilizing ability enhancing, since formula is not perfect, technique is immature and equipment manufacturing technology
Fall behind etc. reasons, cause the medicinal effects of iodine class thimerosal to exaggerate, in addition there are still stability it is poor, corrosivity and stimulation
The problems such as property is big.
Summary of the invention
Based on this, it is necessary to provide a kind of stable quality, corrosivity and irritation is small, sterilizing ability is strong iodic disinfecting liquid.
A kind of iodic disinfecting liquid, in terms of mass percentage, including following components:
The Chinese medicine composition is the ethanol extract of dandelion, Fructus Forsythiae and honeysuckle.
Above-mentioned iodic disinfecting liquid, by iodine, cosolvent, ethyl alcohol, polyoxethylene octylphenyl phenol ether -10 (OP-10), polyvinyl pyrrole
Alkanone (PVP), Chinese medicine composition, pH adjusting agent, stabilizer and hydroscience compatibility, OP-10, PVP and iodine are complexed to form chelated iodine,
Chinese medicine composition synergy is cooperateed with, sterilizing ability can be effectively improved, reduces corrosivity and irritation；Ethyl alcohol and cosolvent are cooperateed with, no
The dissolubility of iodine can only be improved, and the cation of cosolvent can increase extracellular osmotic pressure, destroy eucaryotic cell structure, be easy to iodine
It penetrates skin barrier and reaches the best use point, enhance sterilization effect；Synergistic stabilizer can effectively increase the stabilization of thimerosal
Property；PH adjusting agent is cooperateed with, makes the pH value 5~6 of thimerosal, further enhances sterilization effect.
In one of the embodiments, in terms of mass percentage, the iodic disinfecting liquid includes following components:
The cosolvent is inorganic salt compounded of iodine in one of the embodiments,.
The cosolvent is selected from least one of potassium iodide, Potassiumiodate and sodium iodide in one of the embodiments,.
The pH adjusting agent is selected from sodium dihydrogen phosphate, citric acid, sodium citrate and citric acid in one of the embodiments,
At least one of potassium.
The stabilizer is selected from least one of glycerol, propylene glycol and sorbierite in one of the embodiments,.
The mass ratio of dandelion, Fructus Forsythiae and honeysuckle is 1:1 in the Chinese medicine composition in one of the embodiments:
1。
The pH value of the iodic disinfecting liquid is 5~6 in one of the embodiments,.
The application also provides a kind of preparation method of iodic disinfecting liquid, and concrete scheme is as follows:
The preparation method of iodic disinfecting liquid described in any of the above embodiments, comprising the following steps:
The polyoxethylene octylphenyl phenol ether -10, polyvinylpyrrolidone, stabilizer and suitable quantity of water are mixed, obtain the
One mixed liquor；
The cosolvent is dissolved in first mixed liquor, iodine and Chinese medicine composition is added, it is small to stand 3 in 40 DEG C of heat preservations
When, obtain the second mixed liquor；
Second mixed liquor, ethyl alcohol and the pH adjusting agent are mixed, excess water constant volume obtains iodic disinfecting liquid.
Specific embodiment
To facilitate the understanding of the present invention, below will to invention is more fully described, and give it is of the invention compared with
Good embodiment.But the invention can be realized in many different forms, however it is not limited to embodiment described herein.Phase
Instead, purpose of providing these embodiments is makes the disclosure of the present invention more thorough and comprehensive.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein "and/or" includes one or more phases
Any and all combinations of the listed item of pass.
The iodic disinfecting liquid of one embodiment, iodine, 0.5%~1.5% matter including 1.5%~3.5% mass percentage
Measure the cosolvent of percentage composition, the ethyl alcohol of 40%~50% mass percentage, 1.0%~2.0% mass percentage it is poly-
Ethylene oxide octyl phenol ether -10 (OP-10), 4.5%~5.5% mass percentage polyvinylpyrrolidone (PVP),
The Chinese medicine composition of 4.0%~6.0% mass percentage, the pH adjusting agent of 0.5%~1.5% mass percentage, 4.5%
The stabilizer of~5.5% mass percentage and the water of surplus.
Further, above-mentioned iodic disinfecting liquid, the hydrotropy of iodine, 1% mass percentage including 2.5% mass percentage
Agent, the ethyl alcohol of 40% mass percentage, the polyoxethylene octylphenyl phenol ether -10 (OP-10) of 1.5% mass percentage, 5%
The polyvinylpyrrolidone (PVP) of mass percentage, the Chinese medicine composition of 5% mass percentage, 1% mass percentage
PH adjusting agent, the stabilizer of 5% mass percentage and the water of surplus.
Further, Chinese medicine composition is the ethanol extract of dandelion, Fructus Forsythiae and honeysuckle.
Wherein, dandelion is clearing heat and detoxicating, has certain killing to make staphylococcus aureus, diphtheria, dysentery, typhoid fever etc.
With；Fructus Forsythiae, clearing heat and detoxicating, dispersing swelling and dissipating binds, dispelling wind and heat from the body have broad-spectrum antibacterial action, to staphylococcus aureus, Hayes dysentery
Bacillus, typhoid bacillus, comma bacillus, Escherichia coli, Pseudomonas aeruginosa, Bordetella pertussis, tubercle bacillus, Diplococcus pneumopniae, haemolysis
Property streptococcus etc. have inhibiting effect, infected by influenza also has inhibiting effect, and has certain antifungic action；Honeysuckle is clear
Thermal detoxification, sterilization antivirus, diuresis are antipruritic, and dispelling wind and heat from the body has the function of broad-spectrum antiseptic, antiviral, inflammation can be treated, to golden yellow
Color staphylococcus, hemolytic streptococcus, Escherichia coli, shigella dysenteriae, comma bacillus, typhoid bacillus etc. have inhibiting effect, quilt
It is described as bouvardin.By dandelion, Fructus Forsythiae and honeysuckle compatibility, synergistic antibiotic and sterilizing effect can reach.
Further, the mass ratio of dandelion, Fructus Forsythiae and honeysuckle is 1:1:1 in Chinese medicine composition.
Further, cosolvent is inorganic salt compounded of iodine.Further, cosolvent is selected from potassium iodide, Potassiumiodate and sodium iodide
At least one of.
In the present embodiment, cosolvent is potassium iodide.
Further, pH adjusting agent in sodium dihydrogen phosphate, citric acid, sodium citrate and potassium citrate at least one
Kind.
In the present embodiment, pH adjusting agent is potassium citrate.
Further, stabilizer is selected from least one of glycerol, propylene glycol and sorbierite.
In the present embodiment, stabilizer is glycerol.
Above-mentioned thimerosal, has the advantages that
1) solvent is made with ethyl alcohol, PVP and OP-10, has solubilising and dissolution assistant effect to iodine.
2) it using ethyl alcohol, PVP and OP-10 as carrier, can be complexed with iodine, form the different chelated iodine of rate of release, effectively
Iodine release slowly, enhances bactericidal effect, reduces the irritation and corrosivity of iodine；And the OP-10 of polyethers, have centainly
Defoaming effect reduces " more bubbles " phenomenon of thimerosal in use.
3) PVP and OP-10 biological degradability is good, and ethyl alcohol is nontoxic, and environmental pollution is small.
4) PVP and OP-10 detergency is stronger, reduces available iodine consumption, has the effect of disinfecting and decontaminating, high-efficient；And
And play and stablize, coordination and it is synergistic the effects of, overcome iodine poorly water-soluble, it is irritant, be easy the disadvantages of coloring.
5) OP-10, PVP and Chinese medicine composition are synergistic, improve sterilizing ability, also have washing decontamination, disinfection and sterilization
The effect of.
Above-mentioned iodic disinfecting liquid is brownish red clarified solution, there is ethyl alcohol and iodine smell, no precipitating.In use, with sterile gauze or
Cotton swab dips a small amount of thimerosal, wipes de- iodine at application site skin wiping at least 2 times or more, then with medical ethanol,
Using effective 2~10g/L of iodine concentration, action time is less than 5min.
The preparation method of the iodic disinfecting liquid of one embodiment, includes the following steps S110~S140:
S110, Chinese medicine composition is provided.
Specifically, honeysuckle, Fructus Forsythiae and dandelion are mixed in proportion, after sterilizing, drying, it is added in ethanol water and soaks
Distillate, as Chinese medicine composition are collected in bubble, distillation.
Wherein, the volume ratio of second alcohol and water is 1:1 in ethanol water.The quality of ethanol water is honeysuckle, Fructus Forsythiae
With 20 times or so of dandelion gross mass.
S120, polyoxethylene octylphenyl phenol ether -10, polyvinylpyrrolidone, stabilizer and suitable quantity of water are mixed, obtains the
One mixed liquor.
OP-10, PVP, stabilizer and suitable quantity of water are mixed, stable solution system can be formed.
S130, cosolvent is dissolved in above-mentioned first mixed liquor, iodine and Chinese medicine composition is added, stand 3 in 40 DEG C of heat preservations
Hour, obtain the second mixed liquor.
It is appreciated that cosolvent is dissolved in above-mentioned first mixed liquor, can be formed to iodine with solubilized and dissolution assistant effect
Solution system, be added iodine after, iodine can dissolve rapidly and be complexed to form chelated iodine with OP-10, PVP, enable iodine in a solvent by
It gradually releases, plays certain slow releasing function, with the fungicidal effectiveness being maintained for a long time, and cation (such as Na of cosolvent+、K+Deng) extracellular osmotic pressure can be increased, cell wall structure is destroyed, so that iodine is rapidly achieved the best use point, strengthens disinfection
Bactericidal effect, then Chinese medicine composition is cooperateed with, further increase sterilizing ability.
S140, above-mentioned second mixed liquor, ethyl alcohol and pH adjusting agent are mixed, excess water constant volume obtains iodic disinfecting liquid.
Wherein, for ethyl alcohol as solvent, volatilization is very fast, and can avoid tradition iodic disinfecting liquid because solvent volatilization is slow influences drug effect
Problem.
Further, the pH value of iodic disinfecting liquid is 5~6.
The iodic disinfecting liquid of above method preparation is effectively sterilized iodine number and is increased, and increased Chinese medicinal ingredients also are cooperateed with to improve and be killed
Bacterium effect is the thimerosal that a kind of fungicidal effectiveness is strong, highly-safe, stability is good.
The following are specific embodiments.
Ingredient requirement:
Iodine, potassium iodide, glycerol and ethyl alcohol: pharmaceutical grade, chemical pure grade and the above rank should meet " the People's Republic of China (PRC)
Pharmacopeia " (two) version in 2015 regulation.
Honeysuckle, Fructus Forsythiae, dandelion: meet the regulation of the Pharmacopoeia of the People's Republic of China (one) version in 2015.
Polyvinylpyrrolidone (PVP): pharmaceutical grade, chemical pure grade and the above rank should meet " People's Republic of China (PRC) doctor
Medicine professional standard YY 0125-93 " regulation.
Polyoxethylene octylphenyl phenol ether -10 (OP-10): chemical pure or its above rank；Ash content≤0.5%, active matter contain
Amount >=99%, hydroxyl value are 80 ± 5.
Water: deionized water.
Embodiment 1
Formula: 1.5g iodine, the ethyl alcohol of KI, 40g of 0.5g, 1.0g OP-10,4.5g PVP, 4.0g Chinese medicine composition
The deionized water of the ethanol extract of Fructus Forsythiae and honeysuckle (dandelion), the potassium citrate of 0.5g, the glycerol of 4.5g and 42.5g.
Preparation method: OP-10, PVP, glycerol and appropriate amount of deionized water mixing are taken, stirs evenly, KI is added, stir to molten
Solution, adds iodine, stirs evenly, and Chinese medicine composition is added thereafter, stirs 1h, and 40 DEG C of heat preservations stand 3 hours, are cooled to room temperature,
Potassium citrate is added, stirs evenly, deionized water constant volume is added, obtains the iodic disinfecting liquid that pH value is 6.
Embodiment 2
Formula: 3.5g iodine, the ethyl alcohol of KI, 50g of 1.5g, 2.0g OP-10,5.5g PVP, 6.0g Chinese medicine composition
The deionized water of the ethanol extract of Fructus Forsythiae and honeysuckle (dandelion), the potassium citrate of 1.5g, the glycerol of 5.5g and 24.5g.
Preparation method: OP-10, PVP, glycerol and appropriate amount of deionized water mixing are taken, stirs evenly, KI is added, stir to molten
Solution, adds iodine, stirs evenly, and Chinese medicine composition is added thereafter, stirs 1h, and 40 DEG C of heat preservations stand 3 hours, are cooled to room temperature,
Potassium citrate is added, stirs evenly, deionized water constant volume is added, obtains the iodic disinfecting liquid that pH value is 5.
Embodiment 3
Formula: 2.5g iodine, the ethyl alcohol of KI, 40g of 1g, 1.5g the Chinese medicine composition of PVP, 5g of OP-10,5g (Pu is public
English, Fructus Forsythiae and the ethanol extract of honeysuckle), the deionized water of the potassium citrate of 1g, the glycerol of 5g and 39g.
Preparation method: OP-10, PVP, glycerol and appropriate amount of deionized water mixing are taken, stirs evenly, KI is added, stir to molten
Solution, adds iodine, stirs evenly, and Chinese medicine composition is added thereafter, stirs 1h, and 40 DEG C of heat preservations stand 3 hours, are cooled to room temperature,
Potassium citrate is added, stirs evenly, deionized water constant volume is added, obtains the iodic disinfecting liquid that pH value is 5.5.
Iodic disinfecting liquid prepared by above-described embodiment 1~3, available iodine content range: 6~10g/L, validity period >=24 month.
Iodic disinfecting liquid prepared by above-described embodiment 1~3 is used to kill microorganism, action time 1min, using suspension
Object bacterial propagule (staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa) is killed in sizing technique measurement, kills logarithm
≥5.00；It is measured using suspension quantitative method test method and kills object fungi (Candida albicans), kill logarithm >=4.00.
Comparative example 1
Comparative example 1 is substantially the same manner as Example 3, unlike, Chinese medicine composition is not contained in comparative example 1.
Iodic disinfecting liquid prepared by comparative example 1 is used to kill microorganism, action time 2min is surveyed using suspension quantitative method
Surely object bacterial propagule (staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa) is killed, kills logarithm >=4.00；
It is measured using suspension quantitative method test method and kills object fungi (Candida albicans), kill logarithm >=4.00.
Comparative example 2
Comparative example 2 is substantially the same manner as Example 3, unlike, the dosage of Chinese medicine composition is 20g in comparative example 2, water
Dosage is 24g.
Iodic disinfecting liquid prepared by comparative example 2 is used to kill microorganism, action time 1min is surveyed using suspension quantitative method
Surely object bacterial propagule (staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa) is killed, kills logarithm >=5.00；
It is measured using suspension quantitative method test method and kills object fungi (Candida albicans), kill logarithm >=4.00.
Compared with Example 3, Chinese medicine composition content used increases in the formula of comparative example 2, that is, increased accordingly dandelion,
Fructus Forsythiae, honeysuckle dosage and extraction process in ethanol consumption and required energy, to bactericidal effect increase it is unobvious, but increase
Material consumption and energy consumption, increase production cost.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (9)
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