CN109270216A - Exhaled breath nitric oxide content detecting system and detecting method thereof - Google Patents
Exhaled breath nitric oxide content detecting system and detecting method thereof Download PDFInfo
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- G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
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Abstract
The present invention relates to technical field of medical auxiliary equipment, disclosing a kind of Exhaled nitric oxide content detection system and its detection method, detection system includes expiratory air acquisition unit, expiratory air pretreatment unit, Exhaled nitric oxide detection unit, processor, information input unit, display unit；Wherein, Exhaled nitric oxide detection unit is the nitrogen dioxide of excitation state using oxidation of nitric oxide, detects excitation state nitrogen dioxide by detector and returns to the energy signal that ground state is discharged, and is carried out nitric oxide production quantitative in expiratory air.The present invention passes through in the preposition expiratory air pretreatment unit of Exhaled nitric oxide detection unit, water mist in expiratory air is removed, interference of the water mist to energy signal is reduced, the accuracy of detection data is improved, while having evaded and having formed the problem of moisture film causes detector to burn out on the detector.
Description
Technical field
The present invention relates to technical field of medical auxiliary equipment, in particular to a kind of Exhaled nitric oxide content detection systems
And its detection method.
Background technique
Exhaled nitric oxide (FeNO) detection is the inspection item that division of respiratory disease is gradually popularized.The entire air flue of people is all
Nitric oxide can be synthesized, Exhaled nitric oxide is typically derived from airway epithelial cell, air flue and blood vessel endothelium interstitial cell
Under nitricoxide synthase effect, arginine deamination generates endogenous nitric oxide.
Under normal physiological conditions, most of nitricoxide synthases are not expressed, and nitricoxide synthase when inflammatory conditions
It is activated, generates a large amount of nitric oxide.Therefore, nitric oxide production content can be used as breathing to a certain extent in expiratory air
The judge index of tract disease；A kind of method that it detects airway inflammation as Noninvasive, can be repeated.Due to bronchoscope
Invasive and Sputum induction experimental technique the complexity checked, Exhaled nitric oxide detection become a kind of screening breathing disease
The potential tool of disease.
Exhaled nitric oxide detection by photochemical method carry out, method for by the oxidation of nitric oxide in expiratory air at
The nitrogen dioxide of the nitrogen dioxide of excitation state, excitation state is extremely unstable, can discharge the photon of particular energy and return to ground state, utilizes
The nitrogen dioxide of detector detection excitation state returns to the energy that the nitrogen dioxide of ground state is discharged, and realizes to the oxygen in expiratory air
It is quantitative to change nitrogen.Existing detection technique typically directly acquires the moisture of subject's exhalation, wherein contain a large amount of water mist, water mist
It in the presence of can absorb portion of energy, and is easy to form moisture film on the detector and influences reception of the detector to energy signal, cause
Serious interference, influences testing result；Moisture film also be easy to cause detector to burn out on detector simultaneously.
Summary of the invention
Based on problem above, the present invention provides a kind of Exhaled nitric oxide content detection system and its detection method,
Interference of the water mist to energy signal can be reduced, the accuracy of detection data is improved, while having evaded and having formed water on the detector
The problem of film causes detector to burn out.
In order to solve the above technical problems, the present invention provides a kind of Exhaled nitric oxide content detection systems, including exhale
Outlet acquisition unit, expiratory air pretreatment unit, Exhaled nitric oxide detection unit, processor, information input unit, display
Unit；
Expiratory air acquisition unit is used to acquire the expiratory air in human airway, and expiratory air is delivered to expiratory air one and is aoxidized
Nitrogen detection unit；
Expiratory air pretreatment unit is series between expiratory air acquisition unit and Exhaled nitric oxide detection unit, is used for
Water mist in expiratory air is filtered, and retains the vaporous water in expiratory air；
Exhaled nitric oxide detection unit is for the detection to Exhaled nitric oxide content, including the oxygen interconnected
Change room and sensing chamber, oxidizing chamber is used for the oxidation of nitric oxide in expiratory air into the nitrogen dioxide of excitation state；Detection interior is set
It is equipped with detector, the nitrogen dioxide that detector is used to detect excitation state returns to the energy signal that the nitrogen dioxide of ground state is discharged,
And the energy signal detected is converted into electric signal；
Processor is used to calculate nitric oxide production content in expiratory air by the electric signal received, and will test result biography
It is handed to display unit；
Information input unit is for inputting the personal information parameter of subject into processor；
Display unit is for showing calculated nitric oxide production content and the personal information of subject.
Further, oxidant used in the oxidizing chamber in Exhaled nitric oxide detection unit is ozone.
Further, expiratory air pretreatment unit includes cyclone filter, and the cyclone filter includes cylinder, the cylinder
Body upper end has top cover, is interspersed with exhaust tube on top cover, and the exhaust tube bottom is located in cylinder lumen, at the top of the exhaust tube
It is connected to the inlet end of Exhaled nitric oxide detection unit；The cylinder body bottom is equipped with the cone cylinder being connected to cylinder lumen,
Cone cylinder heavy caliber edge is connect with cartridge openings edge seal, and the cone cylinder small-caliber end is connected with to be connected to cone cylinder inner cavity
Liquid collecting room；The cylinder lateral wall is provided with airintake direction and the tangent air inlet pipe of cylinder inboard wall close to top cover position, it is described into
Tracheae is connected to the outlet side of expiratory air acquisition unit.
Further, the personal information parameter of information input unit input includes name, gender, age, the body of subject
Temperature, smoking history, symptom type and symptom duration.
In order to solve the above technical problems, the present invention also provides a kind of detection method of Exhaled nitric oxide content, packet
Include following operating procedure:
Step 1: acquisition subject expiratory air: subject expiratory air acquisition position include lower respiratory tract expiratory air and
One or both of nasal cavity expiratory air；
Step 2: the water mist in filtering expiratory air；
Step 3: Exhaled nitric oxide content detection: containing to nitric oxide is carried out through step 2 treated expiratory air
Amount detection；Content of nitric oxide in lower respiratory tract expiratory air is controlled in expiratory air flow velocity when detecting in 50 ± 5ml/s, when continuing
Between be 6~10 seconds；Control is in expiratory air flow velocity in 5~8ml/s, duration when the content of nitric oxide detection of nasal cavity expiratory air
It is 6~10 seconds；
Step 4: input subject's personal information: inputting the personal information of subject, including surname by information input terminal
Name, gender, age, body temperature, smoking history, symptom type and symptom duration；
Step 5: display subject's Exhaled nitric oxide content detection result and personal information.
It further, is on-line checking or offline inspection to the content of nitric oxide detection mode in expiratory air in step 3
It surveys.
Compared with prior art, the beneficial effects of the present invention are: by being arranged before Exhaled nitric oxide detection unit
Cyclone filter removes the water mist in expiratory air as expiratory air pretreatment unit, and remains the gaseous state in former expiratory air
Water reduces interference of the water mist to energy signal, improves detection data under the conditions of not influencing the gaseous component in expiratory air
Accuracy, while having evaded and having formed moisture film the problem of causing detector to burn out on the detector.
Detailed description of the invention
Fig. 1 is the structural block diagram of respiratory disorder detection system of the invention；
Fig. 2 be embodiment 1 in cyclone filter, oxidizing chamber, sensing chamber connection schematic diagram；
Fig. 3 is the top view of the cyclone filter in Fig. 2；
Fig. 4 is the flow chart of one of embodiment 2 Exhaled nitric oxide detection method of content；
Wherein, 1, expiratory air acquisition unit；2, expiratory air pretreatment unit；3, Exhaled nitric oxide detection unit；4,
Processor；5, information input unit；6, display unit；7, oxidizing chamber；8, sensing chamber；9, detector；10, cylinder；11, it is vented
Cylinder；12, cone cylinder；13, liquid collecting room；14, air inlet pipe.
Specific embodiment
The present invention is further illustrated with reference to the accompanying drawings and embodiments, but not as a limitation of the invention.
Embodiment 1:
Referring to Fig. 1-3, a kind of Exhaled nitric oxide content detection system and its detection method, including expiratory air acquisition are single
First 1, expiratory air pretreatment unit 2, Exhaled nitric oxide detection unit 3, processor 4, information input unit 5, display unit
6；
Expiratory air acquisition unit 1 is used to acquire the expiratory air in human airway, and expiratory air is delivered to one oxygen of expiratory air
Change nitrogen detection unit 3；
Expiratory air pretreatment unit 2 is series between expiratory air acquisition unit 1 and Exhaled nitric oxide detection unit 3,
For being filtered to the water mist in expiratory air, and retain the vaporous water in expiratory air；
Exhaled nitric oxide detection unit 3 is for the detection to Exhaled nitric oxide content, including what is interconnected
Oxidizing chamber 7 and sensing chamber 8, oxidizing chamber 7 are used for the oxidation of nitric oxide in expiratory air into the nitrogen dioxide of excitation state；Sensing chamber
Detector 9 is provided in 8, the nitrogen dioxide that detector 9 is used to detect excitation state returns to the energy that the nitrogen dioxide of ground state is discharged
Signal is measured, and the energy signal detected is converted into electric signal；
Processor 4 is used to calculate nitric oxide production content in expiratory air by the electric signal received, and will test result
It is transferred to display unit 6；
Information input unit 5 is for inputting the personal information parameter of subject into processor 4；
Display unit 6 is for showing calculated nitric oxide production content and the personal information of subject.
Oxidant used in oxidizing chamber 7 in Exhaled nitric oxide detection unit 3 is ozone.
Expiratory air pretreatment unit 2 includes cyclone filter, and the cyclone filter includes cylinder 10, on the cylinder 10
End has top cover, is interspersed with exhaust tube 11 on top cover, 11 bottom of exhaust tube is located in 10 inner cavity of cylinder, the exhaust tube 11
Top is connected to the inlet end of Exhaled nitric oxide detection unit 3；10 bottom of cylinder is equipped with to be connected with 10 inner cavity of cylinder
Logical cone cylinder 12, the 12 heavy caliber edge of cone cylinder and 10 open edge of cylinder are tightly connected, and 12 small-caliber end of cone cylinder connects
It is connected to the liquid collecting room 13 being connected to 12 inner cavity of cone cylinder；10 side wall of cylinder is provided with airintake direction and cylinder close to top cover position
The tangent air inlet pipe 14 of 10 inner walls, the air inlet pipe 14 are connected to the outlet side of expiratory air acquisition unit 1.
In the present embodiment, expiratory air acquisition unit 11 pre-processes the expiratory air input expiratory air of collected subject
Unit 2, expiratory air pretreatment unit 2 are cyclone filter, and expiratory air is entered by air inlet pipe 14 along 10 inner wall tangential direction of cylinder
Cylinder 10 forms eddy flow in cylinder 10；Expiratory air constantly enters in cylinder 10, makes expiratory air in cylinder 10 close to cylinder 10
Spiral inner wall moves down, and is gradually moved to 10 inner wall of cylinder under the action of the centrifugal force；Because the water mist in expiratory air is liquid state
Little particle, can gradually be moved to 10 inner wall of cylinder under the influence of centrifugal force, and accumulate water flow through cone cylinder 12 flow into liquid collecting
Room 13 is not influencing vaporous water；Expiratory air after removing water mist then forms rebound in 12 inner wall of cone cylinder and moves up, finally through arranging
Inflator 11 enters Exhaled nitric oxide detection unit 3, realizes gas-liquid separation in expiratory air.
Oxidant in the oxidizing chamber 7 of Exhaled nitric oxide detection unit 3 is ozone, and the expiratory air after demisting enters
Oxidizing chamber 7, it is defeated immediately after nitric oxide and ozone reaction in expiratory air generate the nitrogen dioxide of excitation state in oxidizing chamber 7
It send to sensing chamber 8, the volume photon that the nitrogen dioxide of excitation state discharges particular energy in sensing chamber 8 returns to ground state, and detector 9 connects
The energy of photon is received, and is converted into electric signal.The photon energy wherein received gets over multilist and shows nitric oxide production content
Higher, electrical signal intensity is higher, and the content of nitric oxide of subject is calculated through processor 4.Information input unit 5 is to processor
The personal information such as gender, age, body temperature, smoking history, symptom type and symptom durations of input subjects in 4, and are examined
The result of the Exhaled nitric oxide of survey passes through display unit 6 together and shows, is correctly treated conducive to doctor to subject.
Embodiment 2:
Referring to fig. 4, a kind of detection method of Exhaled nitric oxide content, including following operating procedure:
Step 1: acquisition subject expiratory air: subject expiratory air acquisition position include lower respiratory tract expiratory air and
One or both of nasal cavity expiratory air；
Step 2: the water mist in filtering expiratory air；
Step 3: Exhaled nitric oxide content detection: containing to nitric oxide is carried out through step 2 treated expiratory air
Amount detection；Content of nitric oxide in lower respiratory tract expiratory air is controlled in expiratory air flow velocity when detecting in 50 ± 5ml/s, when continuing
Between be 6~10 seconds；Control is in expiratory air flow velocity in 5~8ml/s, duration when the content of nitric oxide detection of nasal cavity expiratory air
It is 6~10 seconds；
Step 4: input subject's personal information: inputting the personal information of subject, including surname by information input terminal
Name, gender, age, body temperature, smoking history, symptom type and symptom duration；
Step 5: display subject's Exhaled nitric oxide content detection result and personal information.
In the present embodiment, contained according to the Exhaled nitric oxide that the actual symptoms of subject may be selected to carry out corresponding site
Amount detection.When the main malaise symptoms of subject are cough, expectoration, asthma, abscess of throat, the symptoms such as be short of breath, should acquire by
The lower respiratory tract expiratory air of examination person, acquisition mode is that soft palate is closed when exhaling, by the air-flow of the exhalation of oral cavity acquisition subject, then
It carries out corresponding expiratory air pretreatment, exhaled air flow speed is controlled when content of nitric oxide detects in 50 ± 5ml/s, the duration is
6~10 seconds.Relative to lower respiratory tract, nasal cavity Exhaled nitric oxide can accumulate higher concentration, therefore to lower breathing
When the expiratory air sampling in road, it should be closed soft palate, prevent expiratory air in nasal cavity from entering, influence the detection knot of lower respiratory tract expiratory air
Fruit.
Whens the uncomfortable diseases of subject are mainly shown as intermittent nasal obstruction, runny nose, sneezing etc., the nasal cavity of subject should be acquired
Expiratory air, acquisition mode is to make gas full of two nostrils during holding one's breath using oral cavity natural aspiration, then by single or two
It exhales in a nostril；Corresponding expiratory air pretreatment is carried out again, and exhaled air flow speed is controlled when content of nitric oxide detects in 5 ± 8ml/
S, duration are 6~10 seconds.
It is on-line checking or offline inspection to the content of nitric oxide detection mode in expiratory air in step 3.On-line checking
Fast speed can quickly be judged.But different subject's coutroi velocities is inconsistent, easily leads to detection data poor repeatability,
It can be used for tentatively judging；Offline inspection can control Ventilation Rate, guarantee the repeatability of testing result, at the same can far from instrument into
Row sampling meets remote detection demand.But sample be easy to cause sample to pollute in storage, transportational process, and detection time is long, nothing
Method realizes immediate assessment.Two kinds of detection modes respectively have superiority and inferiority, can select corresponding detection mode according to the actual conditions of subject,
Meets the needs of different.
It as above is the embodiment of the present invention.Design parameter in above-described embodiment and embodiment is merely to understand table
Invention verification process is stated, the scope of patent protection being not intended to limit the invention, scope of patent protection of the invention is still with it
It is all to change with equivalent structure made by specification and accompanying drawing content of the invention subject to claims, it should all similarly wrap
Containing within the scope of the present invention.
Claims (6)
1. a kind of Exhaled nitric oxide content detection system, it is characterised in that: including expiratory air acquisition unit (1), expiratory air
Pretreatment unit (2), Exhaled nitric oxide detection unit (3), processor (4), information input unit (5), display unit
(6)；
The expiratory air acquisition unit (1) is used to acquire the expiratory air in human airway, and expiratory air is delivered to expiratory air one
Nitrogen oxide detection unit (3)；
The expiratory air pretreatment unit (2) is series at expiratory air acquisition unit (1) and Exhaled nitric oxide detection unit (3)
Between, for being filtered to the water mist in expiratory air, and retain the vaporous water in expiratory air；
The Exhaled nitric oxide detection unit (3) is for the detection to Exhaled nitric oxide content, including interconnects
Oxidizing chamber (7) and sensing chamber (8), the oxidizing chamber (7) be used for by the oxidation of nitric oxide in expiratory air at the two of excitation state
Nitrogen oxide；It is provided with detector (9) in the sensing chamber (8), the nitrogen dioxide that the detector (9) is used to detect excitation state returns
The energy signal discharged to the nitrogen dioxide of ground state, and the energy signal detected is converted into electric signal；
The processor (4) is used to calculate nitric oxide production content in expiratory air by the electric signal received, and will test knot
Fruit is transferred to display unit (6)；
The information input unit (5) is used for the personal information parameter of from the input subject to processor (4)；
The display unit (6) is for showing calculated nitric oxide production content and the personal information of subject.
2. a kind of Exhaled nitric oxide content detection system according to claim 1, it is characterised in that: the expiratory air
Oxidant used in oxidizing chamber (7) in nitric oxide detection unit (3) is ozone.
3. a kind of Exhaled nitric oxide content detection system according to claim 1, it is characterised in that: the expiratory air
Pretreatment unit (2) includes cyclone filter, and the cyclone filter includes cylinder (10), and cylinder (10) upper end is with top
It covers, is interspersed with exhaust tube (11) on top cover, exhaust tube (11) bottom is located in cylinder (10) inner cavity, the exhaust tube (11)
Top is connected to the inlet end of Exhaled nitric oxide detection unit (3)；Cylinder (10) bottom is equipped with and cylinder (10)
The cone cylinder (12) of inner cavity connection, cone cylinder (12) the heavy caliber edge and cylinder (10) open edge are tightly connected, the cone cylinder
(12) small-caliber end is connected with the liquid collecting room (13) being connected to cone cylinder (12) inner cavity；Cylinder (10) side wall is close to top cover position
It is provided with airintake direction and the tangent air inlet pipe (14) of cylinder (10) inner wall, the air inlet pipe (14) and expiratory air acquisition unit
(1) outlet side connection.
4. a kind of Exhaled nitric oxide content detection system according to claim 1, it is characterised in that: the information is defeated
Enter unit (5) input personal information parameter include the name of subject, gender, the age, body temperature, smoking history, symptom type and
Symptom duration.
5. a kind of Exhaled nitric oxide detection method of content, which comprises the steps of:
Step 1: the expiratory air of acquisition subject: the expiratory air acquisition position of subject includes lower respiratory tract expiratory air and nasal cavity
One or both of expiratory air；
Step 2: the water mist in filtering expiratory air；
Step 3: Exhaled nitric oxide content detection: carrying out content of nitric oxide inspection to through step 2 treated expiratory air
It surveys；In expiratory air flow velocity in 50 ± 5ml/s, the duration is for control when content of nitric oxide detection in lower respiratory tract expiratory air
6~10 seconds；Control is in expiratory air flow velocity in 5~8ml/s, duration 6 when the content of nitric oxide detection of nasal cavity expiratory air
~10 seconds；
Step 4: input subject's personal information: inputting the personal information of subject, including name, property by information input terminal
Not, age, body temperature, smoking history, symptom type and symptom duration；
Step 5: display subject's Exhaled nitric oxide content detection result and personal information.
6. a kind of Exhaled nitric oxide detection method of content according to claim 5, it is characterised in that: the step 3
In to the content of nitric oxide detection mode in expiratory air be on-line checking or offline inspection.
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| CN111505217A (en) * | 2020-05-19 | 2020-08-07 | 东南大学 | Human body exhaled gas detection system |
| WO2023165386A1 (en) * | 2022-03-01 | 2023-09-07 | 华为技术有限公司 | Gear-adjustable constant flow valve, and measurement apparatus |
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| WO2023165386A1 (en) * | 2022-03-01 | 2023-09-07 | 华为技术有限公司 | Gear-adjustable constant flow valve, and measurement apparatus |
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Application publication date: 20190125 |