CN210673313U - Expiration analysis device - Google Patents
Expiration analysis device Download PDFInfo
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- CN210673313U CN210673313U CN201921063830.3U CN201921063830U CN210673313U CN 210673313 U CN210673313 U CN 210673313U CN 201921063830 U CN201921063830 U CN 201921063830U CN 210673313 U CN210673313 U CN 210673313U
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- 238000001514 detection method Methods 0.000 claims abstract description 42
- 238000001914 filtration Methods 0.000 claims abstract description 6
- 239000000126 substance Substances 0.000 claims description 7
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 7
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 239000007789 gas Substances 0.000 description 60
- 210000003743 erythrocyte Anatomy 0.000 description 10
- 230000029058 respiratory gaseous exchange Effects 0.000 description 5
- 102000001554 Hemoglobins Human genes 0.000 description 4
- 108010054147 Hemoglobins Proteins 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000005259 peripheral blood Anatomy 0.000 description 2
- 239000011886 peripheral blood Substances 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- 206010017740 Gas poisoning Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000000392 somatic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Images
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- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The utility model discloses an exhalation analysis device, which is provided with a CO2 detection unit and a three-way valve which are connected by a pipeline in sequence along the gas advancing path; one path of the three-way valve is communicated with the atmosphere, the other path of the three-way valve is connected with a gas storage unit, the gas storage unit is respectively connected with an exhaust pipeline, a balance pipeline and a detection pipeline, and a first valve is arranged on the exhaust pipeline; the balance pipeline is provided with a second valve and a filtering unit; and the detection pipeline is provided with a pressure pump and a gas detection unit. The utility model provides an expiration analytical equipment and application method's beneficial effect is: through introducing CO2 detecting element, can judge the expiration stage according to the expiration waveform to collect the expiration that needs through the state of coordinating each valve, convenient to use, the result is accurate, has good popularization prospect.
Description
Technical Field
The utility model relates to an expiration composition detects technical field, specifically is an expiration analytical equipment.
Background
The measurement of the components and concentration of the exhaled gas in the human body can help doctors diagnose the diseases of patients, monitor the disease state, observe the treatment effect and the like, for example, the exhaled nitric oxide is used for detecting asthma, and the exhaled carbon monoxide is used for detecting gas poisoning.
The mammal can deliver oxygen to various tissues of the animal body through the erythrocytes, the CO concentration of the alveolar gas can calculate the service life of the erythrocytes of the human body, and whether the sample gas comes from the alveolar gas has larger influence on the result. According to the results of the Strochi et al study, when the somatic red blood cells are in a steady state with a production rate equal to the destruction rate, or hemoglobin is in a state with a synthesis rate equal to the decomposition rate, RBCS can be calculated by measuring the endogenous CO concentration and the peripheral blood hemoglobin concentration Hb of the exhaled breath according to the following formula: rbcs (d) ═ peripheral blood Hb levels (g/L) × 1.38 per endogenous CO concentration (ppm).
Most of the existing devices for calculating the service life of the red blood cells through exhalation analysis are large-scale laboratory devices, the measuring method and the measuring devices cannot directly measure the concentration of endogenous CO in alveolar gas, and the existing test devices for exhaled gas CO need to carry out controlled exhalation under the guidance of operators, so that the existing test devices cannot be used by testers lacking cognition or unsmooth communication.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a can judge automatically that exhale the source and collect the expiration analytical equipment who detects.
In order to achieve the above object, the utility model provides a following technical scheme:
an exhalation analysis device is provided with CO connected by pipeline in sequence along the gas advancing path2A detection unit and a three-way valve; one path of the three-way valve is communicated with the atmosphere, the other path of the three-way valve is connected with a gas storage unit, the gas storage unit is respectively connected with an exhaust pipeline, a balance pipeline and a detection pipeline, and a first valve is arranged on the exhaust pipeline; the balance pipeline is provided with a second valve and a filtering unit; and the detection pipeline is provided with a pressure pump and a gas detection unit.
Preferably, the CO is2And a flow regulating mechanism and a first flow sensor are also arranged between the detection unit and the three-way valve.
Preferably, a humidity balance mechanism is further arranged on the detection pipeline before the pressure pump.
Preferably, a second flow sensor is further provided on the pressure pump.
Preferably, the gas detection unit is one or a combination of several chemical sensors of CO, NO, H2S, H2 and CH 4.
Preferably, the filter unit adsorbs or reacts away the gas to be detected.
Preferably, the CO is2The air inlet end of the detection unit is connected with an air nozzle for the user to exhale through a pipeline
The present application also provides a method of calculating red blood cell life using the breath analysis apparatus, comprising the steps of:
step 1: the user cooperates the mouth with the air tap to carry out normal expiration, and the expiration is completely led into the expiration analysis device through the mouth expiration;
step 2: CO22The detection unit detects a respiration waveform, if the current state is not at the last expiration stage, the three-way valve is communicated with the atmosphere, if the current state is at the last expiration stage, the three-way valve is communicated with the gas storage unit, the first valve is opened, the second valve and the pressure pump are closed, and the maintaining time t at the last expiration stage is recorded1And expiratory flow F recorded by the flow sensor, the user remaining breathing until Σ Ft1When the volume of the gas storage unit is 2V, V is the volume of the gas storage unit, the three-way valve is communicated with the atmosphere, the first valve is closed, and sampling is stopped;
and step 3: opening the second valve and the pressure pump to pump the gas in the gas storage unit into the gas detection unit at a fixed flow rate, and recording the response signal X1Recording the response signal X when the gas detecting unit can not detect the gas to be detected2；
And 4, step 4: the red blood cell life was calculated.
Preferably, the gas detection mechanism at least comprises a CO chemical sensor, and the filtering mechanism is activated carbon for adsorbing CO; in this case, the method for calculating the red blood cell life RBCS in step 4 comprises:
wherein Hb is hemoglobin concentration, and C is CO concentration at the end of expiration;
where K is a constant of the gas detection unit.
The utility model provides an expiration analytical equipment and application method's beneficial effect is: by introducing CO2The detection unit can judge the expiration phase according to the expiration waveform and collect the required expiration by coordinating the state of each valve, so that the detection device is convenient to use, accurate in result and good in popularization prospect.
Drawings
Fig. 1 is a schematic view of an exhalation analyzing apparatus according to an embodiment of the present invention;
figure 2 is an expiratory waveform.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
As shown in fig. 1, the present embodiment provides an exhaled breath analyzing apparatus, including a CO2 detecting unit 1 and a three-way valve 2, which are sequentially disposed along a gas traveling route and connected by a pipe; one path of the three-way valve 2 is directly communicated with the atmosphere, the other path of the three-way valve is connected with a gas storage unit 3, and the gas storage unit 3 is respectively connected with a gas exhaust pipeline 31, a balance pipeline 32 and a detection pipeline 33; the exhaust pipeline 31 is provided with a first valve 311, the balance pipeline 32 is provided with a second valve 321 and a filtering unit 322, and the detection pipeline 33 is provided with a pressure pump 331 and a gas detection unit 332.
In a preferred embodiment, the CO is2A flow regulation is also arranged between the detection unit 1 and the three-way valve 2The mechanism 4 and the first flow sensor 5 adjust different resistance to the exhaled air flow through the flow adjusting mechanism 4 aiming at different detection gases, for example, adjust the exhalation resistance to 5-20 cmH for NO2And O, regulating the expiratory flow to be 40-200 ml/min.
A humidity balance mechanism 333 is further disposed on the detection pipeline 33 before the pressure pump 331, and the humidity of the gas is increased or decreased by the humidity balance mechanism 333 to meet the requirement of the gas detection unit 332.
The pressure pump 331 is further provided with a second flow sensor 334, and the flow rate of the pressure pump 331 is monitored in real time through the second flow sensor 334 and is used for controlling parameters of the pressure pump 331 so as to ensure that the flow rate of the pressure pump 331 meets preset requirements.
The gas detection unit can be determined according to the type of the gas to be detected, and is generally one chemical sensor of CO, NO, H2S, H2 and CH4, and a series combination of multiple chemical sensors can be adopted; the filter unit 322 is determined according to the type of the gas to be detected, and functions to adsorb or react the gas to be detected in the air.
The analysis device provided by the embodiment also needs to be connected with a gas nozzle 6, preferably a replaceable disposable gas nozzle for keeping sanitation, and is communicated with the gas inlet end of the CO2 detection unit 1 through a pipeline.
The present embodiment also provides a method for calculating the lifespan of red blood cells by using the breath analysis apparatus, including the following steps:
step 1: the user cooperates the mouth with the air tap to carry out normal expiration, and the expiration is completely led into the expiration analysis device through the mouth expiration;
step 2: with reference to the expiratory waveform shown in FIG. 2, calculating the lifetime of red blood cells requires detecting the concentration of CO in the alveolar gas, and therefore collecting the expired air at the end of the expiratory waveform, i.e., the third stage, using CO2The detection unit 1 detects a respiration waveform, and if the current state is not the last expiration stage, the three-way valve 2 is communicated with the atmosphere to directly discharge expired gas; if it is at the end of expiration, the three-way valve 2 is connected to the gas storage unit 3, the first valve 331 is opened, and the second valve 321 and the pressure pump 331 are closedThe expired air flow enters the gas storage unit 3 and discharges the gas existing in the gas storage unit 3 from the exhaust duct 31, and the maintenance time t at the end of expiration is recorded1And expiratory flow F recorded by the first flow sensor 5, the user keeping breathing until Σ Ft1When the total intake air amount reaches twice the volume of the gas storage unit 3, the original air in the gas storage unit 3 is substantially completely discharged, and it can be considered that all the gas in the gas storage unit 3 is the exhaled air at the end of expiration; the three-way valve 2 is communicated with the atmosphere, the first valve 311 is closed, and sampling is stopped;
wherein CO is2The detection unit 1 for detecting the respiration waveform is prior art in the field and will not be described herein.
And step 3: the second valve 321 and the pressure pump 331 are opened to draw the gas in the gas storage unit 3 into the gas detection unit 332 at a fixed flow rate, and the response signal X thereof is recorded1Meanwhile, the external air enters the gas storage unit 3 through the balance pipeline 32 to balance the air pressure, the gas to be detected in the air entering the gas storage unit 3 of the device is removed through the filtering unit 322, and when the gas to be detected cannot be detected by the gas detection unit 332, namely the air with the balanced air pressure enters the gas detection unit 332, the response signal X is recorded2；
And 4, step 4: calculating the service life RBCS of the red blood cells,
wherein Hb is hemoglobin concentration, which can be measured in advance by other approaches in the prior art, and C is CO concentration at the end of expiration;
where K is a constant of the gas detection unit, and may be obtained by calibration with a standard substance.
And (3) standard substance calibration process: preparing 100ppm CO standard gas, introducing into an exhalation analysis device, and recordingResponse information Y1Again recording the gas response value Y after passing through the filter unit2The constant K ═ Y of the gas detection unit is calculated1-Y2)/100。
Claims (7)
1. An exhalation analyzing apparatus, characterized in that: CO connected by a pipeline is sequentially arranged along the gas advancing path2A detection unit and a three-way valve; one path of the three-way valve is communicated with the atmosphere, the other path of the three-way valve is connected with a gas storage unit, the gas storage unit is respectively connected with an exhaust pipeline, a balance pipeline and a detection pipeline, and a first valve is arranged on the exhaust pipeline; the balance pipeline is provided with a second valve and a filtering unit; and the detection pipeline is provided with a pressure pump and a gas detection unit.
2. An apparatus for breath analysis according to claim 1, wherein: the CO is2And a flow regulating mechanism and a first flow sensor are also arranged between the detection unit and the three-way valve.
3. An exhalation analysis apparatus as claimed in claim 2, wherein: and a humidity balance mechanism is also arranged on the detection pipeline before the pressure pump.
4. An apparatus for breath analysis according to claim 1, wherein: and a second flow sensor is also arranged on the pressure pump.
5. An apparatus for breath analysis according to claim 1, wherein: the gas detection unit is one or a combination of several chemical sensors of CO, NO, H2S, H2 and CH 4.
6. An apparatus for breath analysis according to claim 5 wherein: the filter unit adsorbs or reacts the gas to be detected.
7. According toAn exhalation breath analysis apparatus as claimed in claim 1, wherein: the CO is2The air inlet end of the detection unit is connected with an air nozzle for the user to exhale through a pipeline.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921063830.3U CN210673313U (en) | 2019-07-09 | 2019-07-09 | Expiration analysis device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921063830.3U CN210673313U (en) | 2019-07-09 | 2019-07-09 | Expiration analysis device |
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| Publication Number | Publication Date |
|---|---|
| CN210673313U true CN210673313U (en) | 2020-06-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201921063830.3U Active CN210673313U (en) | 2019-07-09 | 2019-07-09 | Expiration analysis device |
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| CN (1) | CN210673313U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110226931A (en) * | 2019-07-09 | 2019-09-13 | 合肥妙可莱生物科技有限公司 | A kind of breath analysis device and application method |
-
2019
- 2019-07-09 CN CN201921063830.3U patent/CN210673313U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110226931A (en) * | 2019-07-09 | 2019-09-13 | 合肥妙可莱生物科技有限公司 | A kind of breath analysis device and application method |
| CN110226931B (en) * | 2019-07-09 | 2024-08-23 | 合肥妙可莱生物科技有限公司 | Expiration analysis device and use method |
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