CN109259146A - One plant has effects that inhibit the Lactobacillus rhamnosus of fatty live lesions and its application - Google Patents
One plant has effects that inhibit the Lactobacillus rhamnosus of fatty live lesions and its application Download PDFInfo
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- A23C9/1234—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp.
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Abstract
一株具有抑制脂肪肝病变功效的鼠李糖乳杆菌及其应用，菌株为鼠李糖乳杆菌Lactobacillus rhamnosus NCU2217，已于2018年4月9日保藏在中国微生物菌种保藏管理委员会普通微生物中心，地址：北京市朝阳区北辰西路1号院3号，中国科学院微生物研究所，其简称为CGMCC，保藏编号为CGMCC NO15573，本发明采用的鼠李糖乳杆菌及其制备的食品，在调节高脂饮食诱导的非酒精性脂肪肝病中，表现出抑制肝功能损伤、降低肝脏脂肪积累、改善脂肪肝的微观结构、促进肝损伤修复的作用。
A strain of Lactobacillus rhamnosus with the effect of inhibiting fatty liver disease and its application, the strain is Lactobacillus rhamnosus NCU2217, which has been preserved in the General Microbiology Center of China Microbiological Culture Collection Management Committee on April 9, 2018, Address: No. 3, No. 1, Beichen West Road, Chaoyang District, Beijing, Institute of Microbiology, Chinese Academy of Sciences, referred to as CGMCC, and the preservation number is CGMCC NO15573. In non-alcoholic fatty liver disease induced by fat diet, it shows the effects of inhibiting liver function damage, reducing liver fat accumulation, improving the microstructure of fatty liver, and promoting the repair of liver damage.
Description
Technical field
The invention belongs to microorganism fields, and being specifically related to one plant has effects that inhibit the Lactobacillus rhamnosus of fatty live lesions
And its application.
Background technique
Lactobacillus rhamnosus is that Abroad in Recent Years studies a kind of more probiotic lactic acid bacteria, is widely present in traditional
In fermented dairy product and human gastrointestinal tract.It is very wide that existing great mass of data shows that Lactobacillus rhamnosus has in field of probiotic bacteria
Exploitation and application prospect.Result of study has confirmed that Lactobacillus rhamnosus has following prebiotic function: (1) antibacterial action at present.
According to the report, Lactobacillus rhamnosus is inhibited to some pathogenic bacteria in food and enteron aisle, it is antibacterial caused by fermentation
Substance has inhibiting effect to Gram-positive, negative bacterium and various pathogens；(2) antioxidation.Studies have shown that rhamnose
Bacteria suspension, cell-free extract and the exocellular polysaccharide of lactobacillus all have stronger antioxidant activity；(3) immunoregulation effect.
Lactobacillus rhamnosus can enhance the immune response of mouse intestinal and system, and to the delayed allergy of mouse cell,
Splenic lymphocytes competence for added value and NK cell activity also have remarkable result；(4) intestines problem is treated.But current rhamnose cream
Bacillus is not reported still the effect of alleviating in terms of colitis.
Summary of the invention
Have effects that inhibit the Lactobacillus rhamnosus of fatty live lesions and its application the object of the present invention is to provide one plant.For
Realize object above, the present invention provides following technical schemes:
One plant have effects that inhibit fatty live lesions Lactobacillus rhamnosus and its application, bacterial strain be Lactobacillus rhamnosus
Lactobacillus rhamnosus NCU2217 is deposited in Chinese microorganism strain preservation management on April 9th, 2018
Committee's common micro-organisms center, address: Yard 1, BeiChen xi Road, Chaoyang District, Beijing City 3, Chinese Academy of Sciences's microbe research
Institute, is referred to as CGMCC, and deposit number is CGMCC NO15573.
One plant has effects that inhibit the Lactobacillus rhamnosus of fatty live lesions and its application: the Lactobacillus rhamnosus
Lactobacillus rhamnosus NCU2217 is the derivative of viable bacteria or inactivated bacteria or the bacterial strain.
One plant has effects that inhibit the Lactobacillus rhamnosus of fatty live lesions and its application: the application is applied to food
Field, the food can be fermentation fruits and vegetables, acidified milk, cheese, milk-contained drink, milk powder or other contain the bacterial strain or the bacterium
Any one of the food of strain derivative.
One plant has effects that inhibit the Lactobacillus rhamnosus of fatty live lesions and its application: described to have alleviation colitis function
Imitate specific manifestation are as follows: in the non-alcoholic fatty liver disease for adjusting high fat diet induction, show to inhibit liver dysfunction, reduce
Liver fat accumulation, the microstructure for improving fatty liver, the effect for promoting hepatic injury reparation.
One plant has effects that inhibit the Lactobacillus rhamnosus of fatty live lesions and its application: the application are as follows: rhamnose cream
Bacillus forms composition in the form of food, the large fruits and vegetables of fermenting generate acid it is fresh it is palatable, full of nutrition, natural fruit and vegetables taste is strong simultaneously
Probiotics fermention fruit and vegetable food with good health-care efficacy, comprising: pickles, beverage, slurry, without adding any perfume (or spice) in product
These food additives of smart fragrance, pigment, acid, stabilizer, preservative, all flavors are produced by probiotics fermention fruit and vegetable materials
It is raw.
Beneficial effects of the present invention:
Lactobacillus rhamnosus CGMCC NO.11886 is in the non-alcoholic fatty liver disease for adjusting high fat diet induction, performance
Inhibit liver dysfunction, the microstructure for reducing liver fat accumulation, improving fatty liver, the effect for promoting hepatic injury reparation out.
Detailed description of the invention
Fig. 1 is influence of the Lactobacillus rhamnosus CGMCC NO15573 to Liver Function.
Fig. 2 is serum lipopolysaccharides and cellular immunity factor level.
Fig. 3 is influence of the Lactobacillus rhamnosus CGMCC NO15573 to Induced by High Fat Diet in Rats liver pathology.
Specific embodiment
Experimental example
With reference to the accompanying drawing with experimental example, test data, the present invention is specifically described:
Healthy SD rat, male, 120-150g are placed under feeding environment and adapt to 1 week.Rat is divided into normal group at random
(ND), hyperlipidemia model group (HFD), Lactobacillus rhamnosus CGMCC NO.11886 low dose group (108CFU/mL) and rhamnose cream
4 groups of bacillus CGMCC NO.11886 high dose group (109CFU/mL), every group 10.All rat normal waters, give model
Group, high dose group and low dose group high lipid food.According to 10mL/kg weight to high dose group and low dose group stomach-filling corresponding dosage
Lactobacillus rhamnosus CGMCC NO.11886, hyperlipidemia model group and normal group stomach-filling Isodose physiological saline, continuous 5 weeks.
After experiment, rat pierces through blood sampling, is centrifuged to obtain serum through chloral hydrate anesthesia, heart.Sterile colonic faecal, liver, fat,
Kidney etc. is spare.The calculation formula of liver and fat organs index are as follows: shoot formation=organ mass (g)/rat body weight (g) ×
100.Then using kit measurement serum glutamic pyruvic transminase (ALT) and glutamic-oxalacetic transaminease (AST) activity, total bilirubin is measured
The enzyme activities such as SOD, GSH-Px, CAT and MDA content are measured using enzyme linked immunological kit according to specification in content, serum
Serum lipopolysaccharides (LPS), interleukin (IL) -6, IL-10 and tumor necrosis factor (TNF)-alpha content.
Liver organization is taken to be placed in 10% formalin fixer fixed, using haematoxylin Yihong (hematoxylin
And eosin, H&E) dyeing progress pathological observation.Using gas chromatography measurement liver fat acid composition.
Table 1 is composition
Table 2 is influence of the Lactobacillus rhamnosus CGMCC NO.11886 to rat liver oxidative stress
Experimental result is shown in Figure of description 1,2,3 and subordinate list 1,2, the results show that Lactobacillus rhamnosus CGMCC
NO15573 shows to inhibit liver dysfunction, reduces liver rouge in the non-alcoholic fatty liver disease for adjusting high fat diet induction
Fat accumulation, the microstructure for improving fatty liver, the effect for promoting hepatic injury reparation.
Claims (5)
1. one plant have effects that inhibit fatty live lesions Lactobacillus rhamnosus and its application, bacterial strain be Lactobacillus rhamnosus
Lactobacillus rhamnosus NCU2217 is deposited in Chinese microorganism strain preservation management on April 9th, 2018
Committee's common micro-organisms center, address: Yard 1, BeiChen xi Road, Chaoyang District, Beijing City 3, Chinese Academy of Sciences's microbe research
Institute, is referred to as CGMCC, and deposit number is CGMCC NO15573.
2. one plant according to claim 1 has effects that inhibit the Lactobacillus rhamnosus of fatty live lesions and its application,
Be characterized in that: the Lactobacillus rhamnosus Lactobacillus rhamnosus NCU2217 is viable bacteria or inactivated bacteria or should
The derivative of bacterial strain.
3. one plant according to claim 1 has effects that inhibit the Lactobacillus rhamnosus of fatty live lesions and its application,
Be characterized in that: the application is applied to field of food, and the food can be fermentation fruits and vegetables, acidified milk, cheese, drink containing cream
Material, milk powder or other contain any one of the bacterial strain or the food of the strain derivative.
4. one plant according to claim 1 has effects that inhibit the Lactobacillus rhamnosus of fatty live lesions and its application,
It is characterized in that: described that there is inhibition fatty live lesions specific manifestation are as follows: in the nonalcoholic fatty liver for adjusting high fat diet induction
In disease, shows to inhibit liver dysfunction, the microstructure for reducing liver fat accumulation, improving fatty liver, hepatic injury is promoted to repair
Multiple effect.
5. one plant according to claim 1 has effects that inhibit the Lactobacillus rhamnosus of fatty live lesions and its application,
It is characterized in that: the application are as follows: Lactobacillus rhamnosus forms composition in the form of food, and the large fruits and vegetables of fermenting generate that acid is fresh can
Mouth, full of nutrition, natural fruit and vegetables taste is strong and has the probiotics fermention fruit and vegetable food of good health-care efficacy, comprising: pickles, drink
Expect, slurry, without adding these food additives of any flavors and fragrances, pigment, acid, stabilizer, preservative, institute in product
There is flavor to be generated by probiotics fermention fruit and vegetable materials.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109136130A (en) * | 2018-08-27 | 2019-01-04 | 南昌大学 | One plant of Lactobacillus rhamnosus NCU2217 |
| CN111154682A (en) * | 2020-01-16 | 2020-05-15 | 深圳市沁帆科技有限公司 | Lactobacillus rhamnosus, microbial agent and food product |
| WO2021137495A1 (en) * | 2020-01-02 | 2021-07-08 | 삼육대학교산학협력단 | Pharmaceutical composition for prevention or treatment of non-alcoholic fatty liver disease comprising butyricimonas sp. strain as active ingredient |
| CN114246310A (en) * | 2021-12-23 | 2022-03-29 | 红河宏斌食品有限公司 | Direct-vat probiotic fermented capsicum frutescens and preparation method thereof |
| CN114504083A (en) * | 2020-11-16 | 2022-05-17 | 烟台东宇海珍品有限公司 | A kind of processing method of sea cucumber intestines |
| CN114717147A (en) * | 2022-03-23 | 2022-07-08 | 江南大学 | Metazoan prepared from Lactobacillus rhamnosus and used for relieving fatty liver and obesity, and application thereof |
| CN116676240A (en) * | 2023-07-28 | 2023-09-01 | 善恩康生物科技（苏州）有限公司 | Lactobacillus rhamnosus and application thereof in preventing or treating alcoholic liver disease |
| CN118086148A (en) * | 2024-04-22 | 2024-05-28 | 潍坊君薇生物科技有限责任公司 | Lactobacillus rhamnosus NKU FL1-8 and application thereof in relieving alcoholic liver injury |
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| CN111154682A (en) * | 2020-01-16 | 2020-05-15 | 深圳市沁帆科技有限公司 | Lactobacillus rhamnosus, microbial agent and food product |
| CN114504083A (en) * | 2020-11-16 | 2022-05-17 | 烟台东宇海珍品有限公司 | A kind of processing method of sea cucumber intestines |
| CN114246310A (en) * | 2021-12-23 | 2022-03-29 | 红河宏斌食品有限公司 | Direct-vat probiotic fermented capsicum frutescens and preparation method thereof |
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| CN114717147A (en) * | 2022-03-23 | 2022-07-08 | 江南大学 | Metazoan prepared from Lactobacillus rhamnosus and used for relieving fatty liver and obesity, and application thereof |
| CN114717147B (en) * | 2022-03-23 | 2023-07-25 | 江南大学 | Post-natal element prepared from lactobacillus rhamnosus and used for relieving fatty liver and obesity and application thereof |
| CN116676240A (en) * | 2023-07-28 | 2023-09-01 | 善恩康生物科技（苏州）有限公司 | Lactobacillus rhamnosus and application thereof in preventing or treating alcoholic liver disease |
| CN116676240B (en) * | 2023-07-28 | 2023-10-31 | 善恩康生物科技（苏州）有限公司 | Lactobacillus rhamnosus and application thereof in preventing or treating alcoholic liver disease |
| CN118086148A (en) * | 2024-04-22 | 2024-05-28 | 潍坊君薇生物科技有限责任公司 | Lactobacillus rhamnosus NKU FL1-8 and application thereof in relieving alcoholic liver injury |
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