CN109172728A - A kind of drug for treating the proliferation of mammary gland - Google Patents
A kind of drug for treating the proliferation of mammary gland Download PDFInfo
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- CN109172728A CN109172728A CN201811287851.3A CN201811287851A CN109172728A CN 109172728 A CN109172728 A CN 109172728A CN 201811287851 A CN201811287851 A CN 201811287851A CN 109172728 A CN109172728 A CN 109172728A
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- 239000003814 drug Substances 0.000 title claims abstract description 34
- 210000005075 mammary gland Anatomy 0.000 title claims abstract description 30
- 229940079593 drug Drugs 0.000 title claims abstract description 25
- 230000035755 proliferation Effects 0.000 title claims abstract description 25
- 239000000843 powder Substances 0.000 claims abstract description 22
- 241000717739 Boswellia sacra Species 0.000 claims abstract description 10
- 240000007311 Commiphora myrrha Species 0.000 claims abstract description 10
- 235000006965 Commiphora myrrha Nutrition 0.000 claims abstract description 10
- 239000004863 Frankincense Substances 0.000 claims abstract description 10
- 235000007265 Myrrhis odorata Nutrition 0.000 claims abstract description 10
- 241000237502 Ostreidae Species 0.000 claims abstract description 10
- 244000179560 Prunella vulgaris Species 0.000 claims abstract description 10
- 235000010674 Prunella vulgaris Nutrition 0.000 claims abstract description 10
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 10
- 235000020636 oyster Nutrition 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 244000290970 Tetrapanax papyrifer Species 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims description 13
- 241000245665 Taraxacum Species 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 6
- 239000004375 Dextrin Substances 0.000 claims description 5
- 229920001353 Dextrin Polymers 0.000 claims description 5
- 235000019425 dextrin Nutrition 0.000 claims description 5
- 206010020718 hyperplasia Diseases 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 8
- 208000002193 Pain Diseases 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- 206010006272 Breast mass Diseases 0.000 abstract description 2
- 230000003213 activating effect Effects 0.000 abstract description 2
- 238000013329 compounding Methods 0.000 abstract description 2
- 230000007717 exclusion Effects 0.000 abstract description 2
- 230000004089 microcirculation Effects 0.000 abstract description 2
- 238000010926 purge Methods 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 240000001949 Taraxacum officinale Species 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 201000010099 disease Diseases 0.000 description 6
- 229940011871 estrogen Drugs 0.000 description 6
- 239000000262 estrogen Substances 0.000 description 6
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 5
- 206010006298 Breast pain Diseases 0.000 description 3
- 208000006662 Mastodynia Diseases 0.000 description 3
- 102000015694 estrogen receptors Human genes 0.000 description 3
- 108010038795 estrogen receptors Proteins 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- 102000003946 Prolactin Human genes 0.000 description 2
- 108010057464 Prolactin Proteins 0.000 description 2
- IWEQQRMGNVVKQW-OQKDUQJOSA-N Toremifene citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 IWEQQRMGNVVKQW-OQKDUQJOSA-N 0.000 description 2
- 230000002124 endocrine Effects 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000000583 progesterone congener Substances 0.000 description 2
- 229940097325 prolactin Drugs 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 229960001603 tamoxifen Drugs 0.000 description 2
- OVBICQMTCPFEBS-SATRDZAXSA-N (2s)-1-[(2s)-2-[[(2s)-2-[[(2r)-2-[[(2s)-2-[[(2s)-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-6-[bi Chemical compound CC(O)=O.CC(O)=O.C([C@@H](C(=O)N[C@H](CCCCN=C(NCC)NCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN=C(NCC)NCC)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 OVBICQMTCPFEBS-SATRDZAXSA-N 0.000 description 1
- 206010061623 Adverse drug reaction Diseases 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 206010006223 Breast discharge Diseases 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 208000012661 Dyskinesia Diseases 0.000 description 1
- 206010014759 Endometrial neoplasm Diseases 0.000 description 1
- 208000007358 Galactocele Diseases 0.000 description 1
- 206010070840 Gastrointestinal tract irritation Diseases 0.000 description 1
- 102000009151 Luteinizing Hormone Human genes 0.000 description 1
- 108010073521 Luteinizing Hormone Proteins 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 206010036832 Prolactinoma Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- PDMMFKSKQVNJMI-BLQWBTBKSA-N Testosterone propionate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CC)[C@@]1(C)CC2 PDMMFKSKQVNJMI-BLQWBTBKSA-N 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 229940046836 anti-estrogen Drugs 0.000 description 1
- 230000001833 anti-estrogenic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical class C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 description 1
- 230000009137 competitive binding Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- POZRVZJJTULAOH-LHZXLZLDSA-N danazol Chemical compound C1[C@]2(C)[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=CC2=C1C=NO2 POZRVZJJTULAOH-LHZXLZLDSA-N 0.000 description 1
- 229960000766 danazol Drugs 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 description 1
- 229940005501 dopaminergic agent Drugs 0.000 description 1
- 201000003914 endometrial carcinoma Diseases 0.000 description 1
- 230000002357 endometrial effect Effects 0.000 description 1
- 239000000328 estrogen antagonist Substances 0.000 description 1
- 229940043168 fareston Drugs 0.000 description 1
- 108700032141 ganirelix Proteins 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 201000010758 lactocele Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004914 menses Anatomy 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 230000027758 ovulation cycle Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000001072 progestational effect Effects 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 208000030153 prolactin-producing pituitary gland adenoma Diseases 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229960001712 testosterone propionate Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960004167 toremifene citrate Drugs 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/483—Gleditsia (locust)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
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Abstract
The invention discloses a kind of drugs for treating the proliferation of mammary gland, specially pharmaceutical compounding techniques field.The drug of the treatment proliferation of mammary gland includes following raw material: 20-30 parts of dandelion, 10-15 parts of great Bei, 10-15 parts of oyster, 15-20 parts of rhizoma anemarrhenae, 5-10 parts of Prunella vulgaris, 5-10 parts of the spina gleditsiae stem pith of the rice-paper plant, 5-10 parts of olibanum, 6-10 parts of myrrh.Such Chinese medicine has exclusion breast lump, dispersing stagnated hepatoqi, activating microcirculation and removing stasis medicinal, medicinal powder for relieving pain knot, clearing heat and detoxicating, purging intense heat, the multiple efficacies such as nourishing Yin and moistening dryness, apocenosis.There is preferable treatment proliferation of mammary gland effect, and prescription is simple, cheap, using effect is good, and it is hormone-free, it has no toxic side effect to body.
Description
Technical field
The present invention relates to a kind of drugs for treating the proliferation of mammary gland, specially pharmaceutical compounding techniques field.
Background technique
The proliferation of mammary gland is the most common women's diseases, and disease incidence accounts for the first place of mammary gland disease, has been mainly in the menstrual cycle
Women, disease incidence is about between 40%~50%；Its basic pathology variation be mammary gland constituent hyperplasia, structure,
Exception is shown in quantity and tissue morphology, is substantially mammary gland normal configuration caused by a kind of physiology hyperplasia and subinvolution
Disorder；
The classical symptom of the proliferation of mammary gland is breast pain, lump in breast, nipple discharge, according to cyclomastopathy endocrine disturbance
Pathogenesis；Western medicine cyclomastopathy is to adjust ovarian endocrine or block hormonal action target spot, blocks morbidity link,
Alleviate symptom, therefore mostly uses the therapeutic scheme for inhibiting estrogen drugs.Its Western medicine has: 1. tamoxifen (tamoxifen)
Class: being a kind of antiestrogen of nonsteroidal for estrogen receptor antagon, is widely used in treating the proliferation of mammary gland, is
Current most effective therapeutic agent；Main mechanism is the estrogen receptor with estrogen competitive binding target cell, is directly sealed
Estrogen receptor is closed, the effect of estrogen is blocked.Most of case breast pain can also recur after drug withdrawal, and side effect is dry
Menstruation is disturbed, shows as menses reduction, menstruation is postponed or in advance, endometrial thickness is obvious, menoxenia；It takes for a long time, and has
Dramatically increase the risk for suffering from carcinoma of endometrium；Furthermore Toremifene Citrate (fareston) has similar to tamoxifen
Pharmacological action and adverse reaction.2. bromocriptine class Dopaminergic Agents: inhibit the secretion of tethelin prolactin(PRL,
Without influencing other pituitrins, it can be used for treating by the excessively high caused various illnesss of prolactin(PRL, inhibit or reduce prolactinoma,
Restore the normal secretions of lutropin, reduce the quantity and volume of galactocele or brief summary, it is uneven to mitigate progestogen/estrogen
Breast pain caused by weighing apparatus；The side effect of this medicine is dizzy sleepy, GI irritation, prosopospasm, illusion, dyskinesia etc..
3. hormone medicine: such as progesterone, testosterone propionate, danazol, such drug main function mechanism be using androgen or
Progestational hormone fights the estrogen increased；To adjust the balance of intracorporal estrogen and progestogen level, mitigate pain, softens tubercle；But mesh
It is preceding that oneself seldom applies such drug as the routine administration for treating this disease, because while hormone therapy initial performances are pretty good, but by
The amount and application time of input hormone are difficult snugly to be suitble to the needs of this disease when treatment, often exceed the proper limits in righting a wrong it
Disadvantage；Misapplication will certainly more aggravate this unbalance state.Therefore, relatively mild Chinese traditional treatment mode is got at present
More to attract attention.
Summary of the invention
The purpose of the present invention is to provide a kind of drugs for treating the proliferation of mammary gland.
To achieve the above object, the invention provides the following technical scheme: a kind of drug for treating the proliferation of mammary gland includes following
Raw material: 20-30 parts of dandelion, 10-15 parts of great Bei, 10-15 parts of oyster, 15-20 parts of rhizoma anemarrhenae, 5-10 parts of Prunella vulgaris, soap
5-10 parts of Medulla Trevesiae palmatae, 5-10 parts of olibanum, 6-10 parts of myrrh.
Further preferably, the drug of the treatment proliferation of mammary gland includes following raw material: 25 parts of dandelion, great Bei
12 parts, 12 parts of oyster, 18 parts of rhizoma anemarrhenae, 8 parts of Prunella vulgaris, 8 parts of the spina gleditsiae stem pith of the rice-paper plant, 8 parts of olibanum, 8 parts of myrrh.
A kind of drug that treating the proliferation of mammary gland the preparation method comprises the following steps: the raw material of the drug according to the treatment proliferation of mammary gland
Proportion, dandelion, great Bei, oyster, rhizoma anemarrhenae, Prunella vulgaris, the spina gleditsiae stem pith of the rice-paper plant, olibanum, myrrh are mixed and are ground into 150-200
Purpose medicinal powder, medicinal powder is uniformly mixed, and obtains medicinal powder mixture；Medicinal powder mixture and dextrin are mixed according to the mass ratio of 1:1-2
After conjunction plus hydraulic pressure piece can be made into Chinese medicinal tablet.
Compared with prior art, beneficial effects of the present invention are as follows: such Chinese medicine has exclusion breast lump, soothing the liver
Qi-regulating, activating microcirculation and removing stasis medicinal, medicinal powder for relieving pain knot, clearing heat and detoxicating, purging intense heat, the multiple efficacies such as nourishing Yin and moistening dryness, apocenosis.There is preferable treatment mammary gland
Hyperplasia effect, and prescription is simple, cheap, using effect is good, and it is hormone-free, it has no toxic side effect to body.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction in the embodiment of the present invention, it is clear that institute
The embodiment of description is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention,
Every other embodiment obtained by those of ordinary skill in the art without making creative efforts, belongs to this hair
The range of bright protection.
Embodiment 1:
A kind of drug that treating the proliferation of mammary gland the preparation method comprises the following steps: matching according to the raw material of the drug of the treatment proliferation of mammary gland
Than by 20-30 parts of dandelion, 10-15 parts of great Bei, 10-15 parts of oyster, 15-20 parts of rhizoma anemarrhenae, 5-10 parts of Prunella vulgaris, the spina gleditsiae stem pith of the rice-paper plant
5-10 parts, 5-10 parts of olibanum, 6-10 parts of myrrh mix the medicinal powder for being ground into 150 mesh, medicinal powder is uniformly mixed, medicine is obtained
Powder mixture；After medicinal powder mixture and dextrin are mixed according to the mass ratio of 1:1 plus hydraulic pressure piece can be made into Chinese medicinal tablet.
Embodiment 2:
A kind of drug that treating the proliferation of mammary gland the preparation method comprises the following steps: matching according to the raw material of the drug of the treatment proliferation of mammary gland
Than by 20-30 parts of dandelion, 10-15 parts of great Bei, 10-15 parts of oyster, 15-20 parts of rhizoma anemarrhenae, 5-10 parts of Prunella vulgaris, the spina gleditsiae stem pith of the rice-paper plant
5-10 parts, 5-10 parts of olibanum, 6-10 parts of myrrh mix the medicinal powder for being ground into 200 mesh, medicinal powder is mixed
Uniformly, medicinal powder mixture is obtained；Adding hydraulic pressure piece after medicinal powder mixture and dextrin are mixed according to the mass ratio of 1:2 is in can be made into
Tablet.
Embodiment 3:
A kind of drug that treating the proliferation of mammary gland the preparation method comprises the following steps: matching according to the raw material of the drug of the treatment proliferation of mammary gland
Than by 20-30 parts of dandelion, 10-15 parts of great Bei, 10-15 parts of oyster, 15-20 parts of rhizoma anemarrhenae, 5-10 parts of Prunella vulgaris, the spina gleditsiae stem pith of the rice-paper plant
5-10 parts, 5-10 parts of olibanum, 6-10 parts of myrrh mix the medicinal powder for being ground into 180 mesh, medicinal powder is uniformly mixed, medicine is obtained
Powder mixture；After medicinal powder mixture and dextrin are mixed according to the mass ratio of 1:1.5 plus hydraulic pressure piece can be made into Chinese medicinal tablet.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (3)
1. a kind of drug for treating the proliferation of mammary gland, it is characterised in that: the drug of the treatment proliferation of mammary gland includes following weight
Part raw material: 20-30 parts of dandelion, 10-15 parts of great Bei, 10-15 parts of oyster, 15-20 parts of rhizoma anemarrhenae, 5-10 parts of Prunella vulgaris, spina gleditsiae are logical
5-10 parts careless, 5-10 parts of olibanum, 6-10 parts of myrrh.
2. a kind of drug for treating the proliferation of mammary gland according to claim 1, it is characterised in that: the treatment proliferation of mammary gland
Drug include following raw material: 25 parts of dandelion, 12 parts of great Bei, 12 parts of oyster, 18 parts of rhizoma anemarrhenae, 8 parts of Prunella vulgaris, spina gleditsiae
8 parts of the stem pith of the rice-paper plant, 8 parts of olibanum, 8 parts of myrrh.
3. a kind of preparation method for the drug for treating the proliferation of mammary gland, it is characterised in that: specific the preparation method comprises the following steps: according to treatment mammary gland
The raw material of the drug of hyperplasia matches, by dandelion, great Bei, oyster, rhizoma anemarrhenae, Prunella vulgaris, the spina gleditsiae stem pith of the rice-paper plant, olibanum, myrrh
The medicinal powder for being ground into 150-200 mesh is mixed, medicinal powder is uniformly mixed, obtains medicinal powder mixture；By medicinal powder mixture and
After dextrin is mixed according to the mass ratio of 1:1-2 plus hydraulic pressure piece can be made into Chinese medicinal tablet.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1692933A (en) * | 2005-04-15 | 2005-11-09 | 扬子江药业集团有限公司 | Compound traditional Chinese medicine for treating proliferation of mammary gland, and its prepn. method |
| CN101912587A (en) * | 2010-07-17 | 2010-12-15 | 苗丽华 | Medicament for treating cyclomastopathy |
| CN102988543A (en) * | 2012-11-21 | 2013-03-27 | 郑州瑞龙制药股份有限公司 | Traditional Chinese medicine for treating hyperplasia of mammary glands and preparation method of traditional Chinese medicine |
| CN107019780A (en) * | 2017-02-04 | 2017-08-08 | 洛阳士雄聚元医疗集团股份有限公司 | A kind of Chinese medicine composition for treating the proliferation of mammary gland |
-
2018
- 2018-10-31 CN CN201811287851.3A patent/CN109172728A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1692933A (en) * | 2005-04-15 | 2005-11-09 | 扬子江药业集团有限公司 | Compound traditional Chinese medicine for treating proliferation of mammary gland, and its prepn. method |
| CN101912587A (en) * | 2010-07-17 | 2010-12-15 | 苗丽华 | Medicament for treating cyclomastopathy |
| CN102988543A (en) * | 2012-11-21 | 2013-03-27 | 郑州瑞龙制药股份有限公司 | Traditional Chinese medicine for treating hyperplasia of mammary glands and preparation method of traditional Chinese medicine |
| CN107019780A (en) * | 2017-02-04 | 2017-08-08 | 洛阳士雄聚元医疗集团股份有限公司 | A kind of Chinese medicine composition for treating the proliferation of mammary gland |
Non-Patent Citations (2)
| Title |
|---|
| 史柯: "消瘰丸临床应用观察", 《河南中医》 * |
| 唐昊等: "叶腾辉主任治疗妇科疾病经验举隅", 《云南中医中药杂志》 * |
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Application publication date: 20190111 |