CN109071498A - 激酶抑制剂及其制备方法和用途 - Google Patents
激酶抑制剂及其制备方法和用途 Download PDFInfo
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- CN109071498A CN109071498A CN201880001642.XA CN201880001642A CN109071498A CN 109071498 A CN109071498 A CN 109071498A CN 201880001642 A CN201880001642 A CN 201880001642A CN 109071498 A CN109071498 A CN 109071498A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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Abstract
本发明涉及凋亡信号调节激酶1(ASK1)抑制剂、包含其的药物组合物、其制备方法和中间体及其用于预防或治疗ASK1介导的疾病的用途。
Description
PCT国内申请，说明书已公开。
Claims (12)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710083353 | 2017-02-16 | ||
| CN2017100833536 | 2017-02-16 | ||
| PCT/CN2018/074263 WO2018149284A1 (zh) | 2017-02-16 | 2018-01-26 | 激酶抑制剂及其制备方法和用途 |
Publications (2)
| Publication Number | Publication Date |
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| CN109071498A true CN109071498A (zh) | 2018-12-21 |
| CN109071498B CN109071498B (zh) | 2021-03-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201880001642.XA Active CN109071498B (zh) | 2017-02-16 | 2018-01-26 | 激酶抑制剂及其制备方法和用途 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN109071498B (zh) |
| WO (1) | WO2018149284A1 (zh) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109071448A (zh) * | 2017-01-22 | 2018-12-21 | 福建广生堂药业股份有限公司 | Ask1抑制剂及其制备方法和应用 |
| CN110294742A (zh) * | 2018-03-21 | 2019-10-01 | 山东轩竹医药科技有限公司 | 并环类ask1抑制剂及其应用 |
| CN111808079A (zh) * | 2020-08-05 | 2020-10-23 | 中国药科大学 | 吲哚类ask1小分子抑制剂及其制备方法和应用 |
| CN113234053A (zh) * | 2021-05-30 | 2021-08-10 | 吉林农业大学 | 裂环羽扇豆烷衍生物及在制备ask1抑制剂中的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018157277A1 (en) * | 2017-02-28 | 2018-09-07 | Eli Lilly And Company | Isoquinolin and naphthydrin compounds |
| JOP20190221A1 (ar) | 2017-04-05 | 2019-09-23 | Seal Rock Therapeutics Inc | مركبات مثبطات كيناز منظم لإشارات الاستماتة 1 (ask1) واستخداماتها |
| MX2019013275A (es) | 2017-05-12 | 2020-07-27 | Enanta Pharm Inc | Inhibidores de la quinasa 1 reguladora de la señal de apoptosis y métodos de uso de estos. |
| US10253018B2 (en) | 2017-05-25 | 2019-04-09 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| WO2018218044A2 (en) | 2017-05-25 | 2018-11-29 | Enanta Pharmaceuticals Inc | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US10450301B2 (en) | 2017-05-25 | 2019-10-22 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| TW201908306A (zh) * | 2017-07-18 | 2019-03-01 | 大陸商南京聖和藥業股份有限公司 | 作為ask抑制劑的雜環化合物及其應用 |
| WO2019046186A1 (en) | 2017-08-28 | 2019-03-07 | Enanta Pharmaceuticals, Inc. | INHIBITORS OF KINASE 1 REGULATING THE APOPTOTIC SIGNAL CONTAINING TETRAZOLES AND METHODS OF USE THEREOF |
| CN109456308B (zh) * | 2017-09-06 | 2022-11-29 | 南京圣和药业股份有限公司 | 作为ask抑制剂的杂环化合物及其应用 |
| CN109956928B (zh) * | 2017-12-14 | 2021-07-09 | 四川科伦博泰生物医药股份有限公司 | 吡啶类化合物、其制备方法及用途 |
| US11434249B1 (en) | 2018-01-02 | 2022-09-06 | Seal Rock Therapeutics, Inc. | ASK1 inhibitor compounds and uses thereof |
| MX2020011225A (es) | 2018-05-02 | 2021-01-20 | Enanta Pharm Inc | Tetrazol que contiene inhibidores de la cinasa 1 reguladora de la señal de apoptosis y métodos de uso de los mismos. |
| WO2019213239A1 (en) | 2018-05-02 | 2019-11-07 | Enanta Pharmaceuticals Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| WO2020041417A1 (en) | 2018-08-22 | 2020-02-27 | Enanta Pharmaceuticals, Inc. | Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| KR102288434B1 (ko) * | 2018-10-18 | 2021-08-12 | 에이치케이이노엔 주식회사 | 신규한 (이소프로필-트리아졸릴)피리디닐 치환된 벤조옥사지논 또는 벤조티아지논 유도체 및 이의 용도 |
| WO2020106707A1 (en) | 2018-11-19 | 2020-05-28 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US11466033B2 (en) | 2019-03-25 | 2022-10-11 | Enanta Pharmaceuticals, Inc. | Substituted pyridines as apoptosis signal-regulating kinase 1 inhibitors |
| US20220242850A1 (en) * | 2019-07-30 | 2022-08-04 | Janssen Pharmaceutica Nv | Phthalazin-1-one derivatives useful as grk2 inhibitors |
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| CN104169260A (zh) * | 2012-03-09 | 2014-11-26 | 卡尔那生物科学株式会社 | 新三嗪衍生物 |
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- 2018-01-26 CN CN201880001642.XA patent/CN109071498B/zh active Active
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| CN103582637A (zh) * | 2011-05-17 | 2014-02-12 | 弗·哈夫曼-拉罗切有限公司 | 酪氨酸激酶抑制剂 |
| US20140161801A1 (en) * | 2011-05-26 | 2014-06-12 | Xuanzhu Pharma Co., Ltd. | Quinazoline derivative as tyrosine-kinase inhibitor, preparation method therefor and application thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109071448A (zh) * | 2017-01-22 | 2018-12-21 | 福建广生堂药业股份有限公司 | Ask1抑制剂及其制备方法和应用 |
| CN109071448B (zh) * | 2017-01-22 | 2020-03-17 | 福建广生堂药业股份有限公司 | Ask1抑制剂及其制备方法和应用 |
| US10787435B2 (en) | 2017-01-22 | 2020-09-29 | Fuijan Cosunter Pharmaceutical Co. Ltd. | ASK1 inhibitor and preparation method and use thereof |
| CN110294742A (zh) * | 2018-03-21 | 2019-10-01 | 山东轩竹医药科技有限公司 | 并环类ask1抑制剂及其应用 |
| CN110294742B (zh) * | 2018-03-21 | 2023-01-31 | 山东轩竹医药科技有限公司 | 并环类ask1抑制剂及其应用 |
| CN111808079A (zh) * | 2020-08-05 | 2020-10-23 | 中国药科大学 | 吲哚类ask1小分子抑制剂及其制备方法和应用 |
| CN113234053A (zh) * | 2021-05-30 | 2021-08-10 | 吉林农业大学 | 裂环羽扇豆烷衍生物及在制备ask1抑制剂中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109071498B (zh) | 2021-03-30 |
| WO2018149284A1 (zh) | 2018-08-23 |
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