CN109045219B - A kind of Hongmaocao compound external ointment for treating female rabbit mastitis - Google Patents
A kind of Hongmaocao compound external ointment for treating female rabbit mastitis Download PDFInfo
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Abstract
本发明提供了一种用于治疗母兔乳房炎的红茂草复方外用膏剂，这样制得：取红茂草段、苦苣、蒲公英、槐米、淡竹叶、橘核、煅石膏和可可豆油，混匀红茂草段、苦苣、蒲公英、槐米、淡竹叶和橘核，加上浸泡，煎煮，滤过，浓缩药液，加入研磨后的煅石膏和可可豆油，搅拌均匀，制得用于治疗母兔乳房炎的红茂草复方外用膏剂。该复方外用膏剂采用全天然中草药制成，用于治疗母兔乳房炎；无毒副作用，安全有效。复方配比，日间+夜间（日间5次，夜间2次）涂抹给药治疗5～8d内痊愈，7d为一疗程，治愈率达96%以上。The invention provides a compound external ointment for treating female rabbit mastitis, prepared in the following way: taking rhododendron segments, chicory, dandelion, sophora japonica, pale bamboo leaves, orange pits, calcined gypsum and cocoa bean oil , Mix the rhododendron segments, chicory, dandelion, locust rice, pale bamboo leaves and orange pips, add soaking, decoction, filter, concentrate the medicinal liquid, add the ground calcined gypsum and cocoa bean oil, stir well, make There is a compound external ointment of Hongmaocao for the treatment of female rabbit mastitis. The compound external-use ointment is made of all-natural Chinese herbal medicine and is used for treating female rabbit mastitis; it has no toxic and side effects, and is safe and effective. Compound formula, daytime + nighttime (5 times during the day, 2 times at night) smeared and administered to cure within 5 to 8d, 7d is a course of treatment, and the cure rate is over 96%.
Description
Technical Field
The invention belongs to the technical field of Chinese veterinary medicine, and relates to a compound herba dicranostigmae external ointment for treating mastitis of female rabbits.
Background
Mastitis is one of the main diseases of female rabbits, often occurs in the lactation period of about 1-2 weeks after farrowing of the female rabbits, and is mainly caused by pathogenic microorganism infection. The mastitis of the female rabbit has complex pathogeny, is usually caused by pathogenic bacteria infection, more than one hundred kinds of pathogenic bacteria are separated at present, and the main pathogenic bacteria comprise staphylococcus (mostly staphylococcus aureus), enterococcus (mostly enterococcus faecalis), streptococcus (including streptococcus agalactiae, streptococcus dysgalactiae and streptococcus uberis), and the like, so the method brings great difficulty to prevention and treatment. At present, antibiotics are generally adopted for treatment after mastitis occurs, and the defects are many.
After the female rabbit suffers from mastitis, the young rabbit is influenced to eat milk by light people, and the breast of the female rabbit is necrotic or becomes septicemic and dies by heavy people. The mastitis of female rabbit is mostly caused by staphylococcus aureus (Staphylococcus aureus) Acute suppurative inflammation caused by invading hair follicle and sebaceous gland of rabbit is one of common skin diseases of female rabbit. After the disease is suffered, the breast of the female rabbit swells and turns red, the nipple of the female rabbit turns black and dry, the body temperature of the female rabbit is obviously increased, the female rabbit touches the skin to feel hot, the lactation time is short or the female rabbit is refused to lactation, and the emotion is low. Mastitis directly reduces the production performance of the female rabbit and the survival rate of the young rabbit, and causes serious economic loss for farmers. The medicines and the methods for treating the mastitis of the female rabbits are more, the common medicines comprise iodine ointment, intramuscular injection penicillin, procaine and oral antibacterial and anti-inflammatory medicines, and most western medicines can quickly take effect but stop taking effect after treatmentThe medicine is easy to relapse after being taken, has large side effect and is difficult to eradicate. Therefore, a compound Chinese herbal medicine ointment which has high curative effect, safety, reliability, low price and convenient use and is used for treating the mastitis of the female rabbit is urgently needed in the market.
The wild metallocene grass for animals has the effects of sterilizing and diminishing inflammation, clearing away heat and toxic materials, relieving swelling and pain and killing insects. Has obvious curative effect on animal aphtha, mastitis and other diseases. When the concentration of the medical solution of the dicranostigma leptopodum extract reaches 0.30mg/mL, the Minimum Inhibitory Concentration (MIC) of the medical solution to staphylococcus aureus is 0.2000mg/mL, the Minimum Bactericidal Concentration (MBC) of the medical solution is 0.1000mg/mL, and the half Inhibitory Concentration (IC) of the medical solution is reported50) 0.1805 mg/mL; the observation of 50000 times of a transmission electron microscope shows that the structure of staphylococcus aureus cells is unclear, liquid overflows from the periphery, the cell wall is locally thicker than that of a control group, bacterial fragments lacking any intracellular structures can be observed, and the antibacterial effect is obvious. The MIC of herba Rabdosiae Glaucocalycis extract to enterococcus faecalis is 0.1800mg/mL, IC500.2605mg/mL, IC for Streptococcus50Is 1.600 +/-0.3400 mg/mL, and has obvious bacteriostasis.
Disclosure of Invention
The invention aims to provide the compound herba rubiae external paste for treating the mastitis of the female rabbit, which has the advantages of high curative effect, safety, reliability, low price and convenient use.
In order to achieve the purpose, the invention adopts the technical scheme that: a compound herba Rabdosiae Glaucocalycis external ointment for treating female rabbit mastitis is prepared by the following steps:
1) cleaning the dicranostigma leptopodum, removing impurities and non-medicinal parts, and cutting into sections of 1-1.5 cm to obtain dicranostigma leptopodum sections;
removing silt and impurities in the endive to obtain the clean endive;
2) weighing 15-20 g of dicranostigma leptopodum and 5-10 g of clean endive;
weighing traditional Chinese medicine decoction pieces: 10-15 g of dandelion, 3-5 g of sophora flower bud, 5-10 g of lophatherum gracile and 3-5 g of tangerine seed;
weighing 5-10 g of calcined gypsum;
measuring 10-20 mL of cocoa bean oil;
3) uniformly mixing the half grass, the dandelion, the sophora flower bud, the lophatherum gracile, the clean endive and the tangerine seed, adding 200-300 mL of water, soaking for 20-40 min, decocting for 20-30 min with slow fire, filtering, removing waste residues, and concentrating the medicinal liquid into thick paste with the relative density of 1.30 (measured at 80 ℃);
grinding the calcined gypsum into calcined gypsum powder;
4) adding calcined gypsum powder and cocoa bean oil into the thick paste, and uniformly stirring to prepare the compound herba rubiae compound external paste for treating the mastitis of the female rabbit.
The medical performance of each component in the compound external-use paste of the dicranostigma leptopodum is as follows:
1. the red clover is: clearing away heat and toxic material, sterilizing and diminishing inflammation.
2. Dandelion: clear heat and remove toxicity, cure abscess and dissipate nodulation.
3. And (3) flos sophorae immaturus: clearing heat and cooling blood, and resisting bacteria and diminishing inflammation.
4. Herba lophatheri: clear heat and relieve restlessness, induce diuresis to treat stranguria, cool blood and relieve swelling.
5. Endive: resolve abscess and swelling, clear heat and remove toxicity.
6. Calcining gypsum: astringe dampness, promote tissue regeneration, heal wound and stop bleeding.
7. Orange seed: regulate qi, dissipate nodulation and alleviate pain.
8. Cocoa bean oil: and (3) an excipient.
The compound external ointment is prepared by compound compatibility according to the Chinese veterinary medicine theory and the inherent properties of the traditional Chinese medicinal materials such as the red clover and the like of sterilization and inflammation diminishing. In the prescription, the monarch drug, the red clover, is used for clearing heat and removing toxicity; dandelion herb is the key herb for treating abscess by removing abscess and dissipating nodulation, aiming at eliminating inflammation such as redness, swelling, heat and distension. The ministerial medicine sophora flower bud is matched to cool blood and stop bleeding; lophatherum gracile has the effects of clearing heat, relieving restlessness, promoting urination and treating stranguria; the bitter chrysanthemum has the effects of diminishing inflammation and detoxifying and removing carbuncle and swelling. However, if the heat-clearing and detoxifying are used alone, qi stagnation and blood stasis are difficult to eliminate, and swelling and stagnation are not dispersed, so the tangerine seeds are used for promoting qi circulation and removing obstruction in channels, and removing blood stasis and relieving pain; calcined Shi Gao can heal wound and promote granulation, stop bleeding and resolve carbuncle and swelling. Qi moving through the body can dredge nutrient and exterior, and there is no retention of pathogenic factors in nutrient and exterior, so as to remove stasis, swelling and pain. The whole formula is pungent, bitter and cool in property, and integrates the functions of clearing heat and removing toxicity, cooling blood and stopping bleeding, and eliminating carbuncle and removing blood stasis.
The compound external ointment has the effects of clearing heat, removing toxicity, sterilizing and diminishing inflammation. Is suitable for external treatment of various mastitis, especially for female rabbit mastitis caused by staphylococcus aureus, and has rapid onset of drug action and no adverse side effect.
The compound external ointment of the invention utilizes the efficacies of the dicranostigma leptopodum medicine of sterilization, inflammation diminishing, heat clearing and detoxification, has obvious bacteriostatic effect aiming at common pathogenic bacteria of the mastitis of the female rabbits, is matched with Chinese herbal medicines with antibacterial and anti-inflammatory effects such as dandelion, sophora bud, lophatherum gracile, endive, calcined gypsum and the like, is coated in a compound compatibility way, and is used for treating the mastitis of the female rabbits.
The usage and dosage of the compound red cyclopentadienyl grass external ointment of the invention are as follows: the medicine is dipped with a cotton swab in the daytime and is externally applied to the affected part for 3-5 times a day. Dipping with a cotton swab at night, and applying on the affected part for 1-2 times.
The compound herba dicranostigma leptopodii ointment for external use is prepared from all natural Chinese herbal medicines and is used for treating mastitis of female rabbits. Has no toxic and side effects, and is safe and effective. The compound formula is prepared, and the medicine is applied in the daytime and at night (5 times in the daytime and 2 times in the night), the cure is realized within 5-8 days, 7 days is a treatment course, and the cure rate is up to over 86%.
Detailed Description
In order to better understand the invention, the curative effect result of the drug formula on the female rabbit infected with mastitis is described below, the application of the drug formula in the compound external-use ointment of the red clover is described, and the experimental method and the result are as follows.
Example 1
Cleaning the dicranostigma leptopodum, removing impurities and non-medicinal parts, and cutting into sections of 1-1.5 cm to obtain dicranostigma leptopodum sections; removing silt and impurities in the endive to obtain the clean endive; weighing 20g of dicranostigma leptopodum and 10g of clean endive; weighing traditional Chinese medicine decoction pieces: 15g of dandelion, 5g of sophora flower bud, 10g of lophatherum gracile and 5g of tangerine seed. Mixing the above materials, adding 300mL of water, soaking for 30min, decocting with slow fire for 30min, filtering, removing residue, and concentrating the decoction to obtain soft extract with relative density of 1.30 (measured at 80 deg.C); and adding 10g of calcined gypsum powder and 20mL of cocoa bean oil, and uniformly stirring to obtain the compound herba rhodiolae rubrum external ointment for treating the mastitis of the female rabbit.
Curative effect comparison test: 100 6-month-old parturient female rabbits infected with mastitis were selected, randomly divided into 5 groups of 20 rabbits each, and treated with different treatment ointments: the first group is treated by using the compound red cyclopentadienyl grass external ointment of the invention, and the patient is externally rubbed with a cotton swab for 5 times in the daytime. And in the second group, the compound red clover ointment for external use is used for treatment, and the patient is externally rubbed with a cotton swab for 2 times at night. And in the third group, the compound red clover ointment for external use is used for treatment, and cotton swabs are externally applied to the affected part for 5 times in the daytime and 2 times at night. And the fourth group, applying herba Rabdosiae Lophanthoidis decoction with crude drug concentration of 30% to the affected part, 5 times a day. In the fifth group, the affected part was smeared with tap water 5 times a day as a control. The results of the experiment are shown in table 1.
TABLE 1 curative effect of the compound herba Rabdosiae Glaucocalycis ointment for external use on mastitis of female rabbit
As can be seen from Table 1, the compound herba Rabdosiae Lophanthoidis external ointment is applied for 5 times in the day and 2 times at night, has remarkable treatment effect on the mastitis of the skin of the female rabbit, can be cured within 5-8 days generally, has a treatment course of 7 days, and has the cure rate of more than 86%.
The clinical curative effect is as follows: 500 female rabbits suffering from mastitis are clinically treated by the compound herba rhodiolae red external ointment in the Zealand domestic rabbit farm in Wushan county of Gansu province in 10 months to 2018 in 6 months in 2017. The cure rate reaches 69 percent only within 10-12 days of applying and smearing treatment in the daytime; the cure rate reaches over 86 percent within 5-8 days of day and night administration and smearing treatment. The treatment time, the cost and other factors are combined, 7 days are selected as a treatment course, and the treatment effect is most obvious.
Example 2
Cleaning the dicranostigma leptopodum, removing impurities and non-medicinal parts, and cutting into sections of 1-1.5 cm to obtain dicranostigma leptopodum sections; removing silt and impurities in the endive to obtain the clean endive; weighing 18g of dicranostigma leptopodum and 8g of clean endive; weighing traditional Chinese medicine decoction pieces: 12g of dandelion, 4g of sophora flower bud, 8g of lophatherum gracile and 4g of tangerine seed. Mixing the above materials, soaking in 250mL of water for 20min, decocting with slow fire for 25min, filtering, removing residue, and concentrating the decoction to obtain soft extract with relative density of 1.30 (measured at 80 deg.C); adding 8g of calcined gypsum powder and 15mL of cocoa bean oil, and uniformly stirring to obtain the compound herba rhodiolae rubrum external ointment for treating the mastitis of the female rabbit.
Example 3
Cleaning the dicranostigma leptopodum, removing impurities and non-medicinal parts, and cutting into sections of 1-1.5 cm to obtain dicranostigma leptopodum sections; removing silt and impurities in the endive to obtain the clean endive; weighing 15g of dicranostigma leptopodum and 5g of clean endive; weighing traditional Chinese medicine decoction pieces: 10g of dandelion, 3g of sophora flower bud, 5g of lophatherum gracile and 3g of tangerine seed. Mixing the above materials, soaking in 200mL water for 40min, decocting with slow fire for 20min, filtering, removing residue, and concentrating the decoction to obtain soft extract with relative density of 1.30 (measured at 80 deg.C); and adding 5g of calcined gypsum powder and 10mL of cocoa bean oil, and uniformly stirring to obtain the compound herba rhodiolae rubrum external ointment for treating the mastitis of the female rabbit.
Claims (3)
1. A compound herba half-grass external ointment for treating female rabbit mastitis is characterized in that the compound Chinese herbal medicine external ointment is prepared by the following steps:
1) weighing 15-20 g of the dicranostigma leptopodum and 5-10 g of the endive respectively;
the following decoction pieces were weighed respectively: 10-15 g of dandelion, 3-5 g of sophora flower bud, 5-10 g of lophatherum gracile and 3-5 g of tangerine seed;
weighing 5-10 g of calcined gypsum;
taking 10-20 mL of cocoa bean oil;
2) uniformly mixing the dicranostigma leptopodum, the endive, the dandelion, the sophora flower bud, the lophatherum gracile and the tangerine seed, adding 200-300 mL of water, soaking for 20-40 min, and decocting for 20-30 min with slow fire; filtering, and concentrating the filtrate to obtain soft extract with relative density of 1.30;
grinding the calcined gypsum into calcined gypsum powder;
3) adding calcined gypsum powder and cocoa bean oil into the thick paste, and uniformly stirring to prepare the compound herba rubiae compound external paste for treating the mastitis of the female rabbit.
2. The compound ramose scouring rush herb ointment for external use for treating female rabbit mastitis according to claim 1, wherein the ramose scouring rush herb segment in the step 1) is prepared by: selecting the dicranostigma leptopodum, removing impurities and non-medicinal parts, and cutting into sections of 1-1.5 cm to obtain dicranostigma leptopodum sections.
3. The compound ramose scouring rush herb ointment for external use for treating female rabbit mastitis according to claim 1, wherein the chicory in the step 1) is prepared by: removing silt and impurities in the endive to obtain the pure endive.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103735698A (en) * | 2014-01-22 | 2014-04-23 | 辽宁省中药研究所 | External preparation for preventing and/or treating mastitis of mammals and preparation thereof |
| CN104666635A (en) * | 2013-12-03 | 2015-06-03 | 天津市中敖饲料有限公司 | Externally-applied traditional Chinese medicine ointment for treating acute mastitis of dairy cow and preparation method of ointment |
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| CN104666635A (en) * | 2013-12-03 | 2015-06-03 | 天津市中敖饲料有限公司 | Externally-applied traditional Chinese medicine ointment for treating acute mastitis of dairy cow and preparation method of ointment |
| CN103735698A (en) * | 2014-01-22 | 2014-04-23 | 辽宁省中药研究所 | External preparation for preventing and/or treating mastitis of mammals and preparation thereof |
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