CN105560620A - Trauma treatment traditional Chinese medicine preparation - Google Patents
Trauma treatment traditional Chinese medicine preparation Download PDFInfo
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Abstract
The present invention discloses a trauma treatment traditional Chinese medicine preparation prepared from the following traditional Chinese medicinal materials in parts by weight: 200-400 parts of Callicarpa formosana, 200-400 parts of dried garden burnet, 100-400 parts of dalbergia wood, 50-200 parts of dried herba corydalis bungeanae, 50-200 parts of myrrh, 50-200 parts of herba cepbalanoplosis segeti, 50-200 parts of astragalus membranaceus, 10-50 parts of borneol, 10-30 parts of radices lithospermi and 20-40 parts of licorice. Preparation steps are as follows: (1) respectively taking the Callicarpa formosana, garden burnet, dalbergia wood, herba corydalis bungeanae, myrrh, herba cepbalanoplosis segeti, astragalus membranaceus, borneol, radices lithospermi and licorice for drying and crushing, and respectively sieving with a 100-200 mesh screen; and (2) mixing the crushed traditional Chinese medicinal materials evenly, sterilizing and bottling to obtain the trauma treatment traditional Chinese medicine preparation powder. The trauma treatment traditional Chinese medicine preparation can promote wound healing, compared with traditional Chinese medicine and traditional healing methods, and the trauma treatment traditional Chinese medicine preparation is more obvious in bleeding-stopping and pain and swelling-relieving effects, better in antibacterial antimicrobial and necrotic-tissue-removing and granulation-promoting effects, and has advantages which the traditional Chinese medicines do not have. The trauma treatment traditional Chinese medicine preparation can stop bleeding, relieve pains and swelling and can be antibacterial, antimicrobial, thus preventing wound infection, accelerating wound healing, and shortening the hospital stay of patients.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly a kind of Chinese medicine preparation for wound process.
Background technology
Wound is the function and integrity division organized in health.Operation is the important means of disease therapy and wound clinically, simultaneously in some vehicle accidents, often causes the skin and flesh wound of people serious, needs hemostatic suture wound as early as possible.Therefore promotion wound healing, the medicine of control wound infection, always by surgeon is favored.
Su Anping (brief talking the effect of the many repair in trauma of external treatment with Chinese medicine, " the Gansu traditional Chinese medical science ", 2006,19 (4) .1) thinks that wound infection is the major obstacle of tissue repair, and traumatic wounds all inevitably has various germ contamination wound.Body, to the in-house various antibacterial early reaction of intrusion, has nothing to do with pathogen type, but time infection often betides extreme imbalance between Abwehrkraft des Koepers and the microorganism species of intrusion.When wound generation infection is right, the extracellular toxin be secreted when microorganism is in vital movement process with destruction in wound not only causes erythrocyte and hematoblastic destruction, but also make thin vessels smooth muscle contraction, spasm, cause blood capillary to block and local tissue necrosis.Moreover, the comprehensive function of a large amount of bacterial exotoxin, endotoxin and proteolytic enzyme after wound, and biological effect and the radical damage of cytokine is caused by their cytotoxicity, cause tissue edema, hemorrhage, purulent secretion quantity increase, protein is lost in a large number by wound surface sharply to be increased with electrolyte, in the granulation tissue of suppurative wound, albumen is hydrolyzed in a large number, antibacterial invades surrounding tissue in a large number, the hyperplasia that chamber or granulation tissue are hindered in granulation tissue growth filling affects epithelium formation, affects the speed of repair in trauma.
The current product for wound disinfection is mainly based on ethanol and iodine tincture; But such disinfectant can only kill the general antibacterial in place or microorganism, does not have anastalsis and does not also have direct effect to the healing of wound.Chinese patent CN102462732A discloses " a kind of Wound disinfectant and preparation method thereof ", and its active substance is medical alcohol 20-50 part, trichloro hydroxyl diphenyl ether 6-15 part, Herba Clinopodii Polycephali 10-25 part, oils and fats perforatum extract 5-18 part.Trichloro hydroxyl diphenyl ether is wherein conventional antimicrobial activity agent, is usually used in disinfecting articles for use, as medicated soap, body lotion, handwashing liquid etc.; Herba Clinopodii Polycephali is wherein used for hemostasis, oils and fats perforatum extract is used for blood circulation promoting and blood stasis dispelling, and this disinfectant solution is a kind of disinfectant solution that can promote wound healing.But due to Herba Clinopodii Polycephali, oils and fats perforatum extract content very little, the effect that wound is tentatively restrained can only be played; Also need to smear the ointment promoting wound healing after using this disinfectant solution process wound.Therefore the Chinese medicine ingredients contained by " a kind of Wound disinfectant and preparation method thereof " of Chinese patent CN102462732A announcement is few, as the disinfectant solution of process wound, and can only not have the effect having quick-acting haemostatic powder and promote wound healing.
Summary of the invention
The object of this invention is to provide a kind of being made up of natural Chinese medicines material, for clearing up wound quick-acting haemostatic powder, promoting the Chinese medicine preparation for wound process of wound healing.
For achieving the above object, the present invention adopts following technical proposals:
For a Chinese medicine preparation for wound process, be prepared from by the Chinese crude drug of following weight portion:
Folium Callicarpae Formosanae 200-400 part, Radix Sanguisorbae dry product 200-400 part, Lignum Dalbergiae Odoriferae 100-400 part, Herba Corydalis Bungeanae dry product 50-200 part, Myrrha 50-200 part, Herba Cirsii 50-200 part, Radix Astragali 50-200 part, Borneolum Syntheticum 10-50 part, Radix Arnebiae (Radix Lithospermi) 10-30 part, Radix Glycyrrhizae 20-40 part.
Preferably, Folium Callicarpae Formosanae 300 parts, Radix Sanguisorbae dry product 300 parts, Lignum Dalbergiae Odoriferae 180 parts, Herba Corydalis Bungeanae dry product 100 parts, Myrrha 120 parts, Herba Cirsii 100 parts, the Radix Astragali 100 parts, Borneolum Syntheticum 40 parts, Radix Arnebiae (Radix Lithospermi) 12 parts, 20 parts, Radix Glycyrrhizae.
Preferably, Folium Callicarpae Formosanae 400 parts, Radix Sanguisorbae dry product 300 parts, Lignum Dalbergiae Odoriferae 300 parts, Herba Corydalis Bungeanae dry product 120 parts, Myrrha 155 parts, Herba Cirsii 180 parts, the Radix Astragali 180 parts, Borneolum Syntheticum 50 parts, Radix Arnebiae (Radix Lithospermi) 30 parts, 25 parts, Radix Glycyrrhizae.
Preferably, Folium Callicarpae Formosanae 240 parts, Radix Sanguisorbae dry product 400 parts, Lignum Dalbergiae Odoriferae 160 parts, Herba Corydalis Bungeanae dry product 50 parts, Myrrha 80 parts, Herba Cirsii 200 parts, the Radix Astragali 200 parts, Borneolum Syntheticum 10 parts, Radix Arnebiae (Radix Lithospermi) 10 parts, 40 parts, Radix Glycyrrhizae.
Folium Callicarpae Formosanae: property is put down, and taste is micro-pungent, bitter: hemostasis and anti-inflammation, dissipating blood stasis for subsidence of swelling.For traumatic hemorrhage, epistaxis, gingiva bleeding gingival hemorrhage, sprain swell and ache, suppurative skin ulcer, burn.
Radix Sanguisorbae: cold nature; Bitter in the mouth, acid, puckery; Return liver, large intestine channel; Cooling blood for hemostasis, removing toxic substances sore.For burn due to hot liquid or fire, carbuncle sore tumefacting virus.
Lignum Dalbergiae Odoriferae: warm in nature; Acrid in the mouth; Return liver, spleen channel; Promoting flow of QI and blood, pain relieving, hemostasis.For injury from falling down, traumatic hemorrhage.
Herba Corydalis Bungeanae: cold in nature; Bitter in the mouth, pungent; GUIXIN, spleen channel; Heat clearing away poison, subduing inflammation.
Myrrha: property is put down; Bitter in the mouth, pungent; GUIXIN, liver, spleen channel; Promoting blood circulation and stopping pain, detumescence and promoting granulation.For external wounds traumatic injury, skin infection carbuncle, all pain cards of stagnation of blood stasis.
Herba Cirsii: record its nature and flavor according to " China's book on Chinese herbal medicine " sweet; Micro-hardship; Cool in nature.Return liver; Spleen channel.Cooling blood for hemostasis; Clearing heat for detumescence.Main hemoptysis; Spit blood; Epistaxis; Hematuria; Stranguria with blood; Have blood in stool; Dysentery; Metrorrhagia and metrostaxis; Traumatic hemorrhage; Swollen ulcer drug.
The Radix Astragali: record its nature and flavor according to " Chinese Pharmacopoeia " sweet, temperature.Return lung, spleen channel.Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Borneolum Syntheticum: record its nature and flavor according to " Chinese Pharmacopoeia " pungent, bitter, be slightly cold.GUIXIN, spleen, lung meridian.To have one's ideas straightened out refreshment, clearing away heat to alleviate pain.Faint for calentura coma, convulsion, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors is gone into a coma, and conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus is suppurated.
Radix Arnebiae (Radix Lithospermi): cold in nature; Sweet in the mouth, salty; GUIXIN, Liver Channel; Removing heat from blood, invigorates blood circulation, removing toxic substances rash.Contain for heat in blood poison, macule purple is black, skin infection, eczema, burn due to hot liquid or fire.
Radix Glycyrrhizae: property is put down; Sweet; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, carbuncle sore tumefacting virus, cushion toxicity, strong.
Through clinical experiment checking, the present invention promotes that the Chinese medicine of wound healing is compared with traditional therapy, and its hemostasis, pain relieving, detumescence effect are more obvious, and the effect of bacteriostasis antibiosis, removing the necrotic tissue and promoting granulation is better, has the advantage not available for conventional medicament.Folium Callicarpae Formosanae, Radix Sanguisorbae, Lignum Dalbergiae Odoriferae, Herba Corydalis Bungeanae, Myrrha, Herba Cirsii, the Radix Astragali, Borneolum Syntheticum, Radix Arnebiae (Radix Lithospermi), Radix Glycyrrhizae can be worked in coordination with mutually, and gain is complementary, both can stop blooding, pain relieving, detumescence, again can be antibacterial, antibacterial, thus prevent wound infection, accelerating wound healing, shortens the hospital stays of patient.
Present invention also offers a kind of preparation method of the Chinese medicine preparation for wound process, concrete preparation process is as follows:
(1) get pearl leaf, Radix Sanguisorbae, Lignum Dalbergiae Odoriferae, Herba Corydalis Bungeanae, Myrrha, Herba Cirsii, the Radix Astragali, Borneolum Syntheticum, Radix Arnebiae (Radix Lithospermi), Radix Glycyrrhizae respectively, drying and crushing, cross 100-200 mesh sieve.
(2) by the Chinese crude drug mixing after above-mentioned pulverizing, sterilizing, bottling, obtains powder of the present invention.
Certainly, Chinese medicine of the present invention can adopt conventional preparation process to be prepared into powder, unguentum, oil preparation etc.
Visible the present invention promotes that the preparation technique of traditional Chinese medicine of wound healing is simple.The invention of the proved of clinical experiment simultaneously has astringing to arrest bleeding, reducing swelling and alleviating pain, antimicrobial antiphlogistic, and wound healing is fast, and the features such as preventing from scar, have obvious economic and social benefit.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further details.
Embodiment 1:
(1) get Folium Callicarpae Formosanae 300g, Radix Sanguisorbae 300g, Lignum Dalbergiae Odoriferae 180g, Herba Corydalis Bungeanae 100g, Myrrha 120g, Herba Cirsii 100g, Radix Astragali 100g, Borneolum Syntheticum 40g, Radix Arnebiae (Radix Lithospermi) 12g, Radix Glycyrrhizae 20g respectively, drying and crushing, cross 200 mesh sieves.
(2) by the Chinese crude drug mixing after above-mentioned pulverizing, sterilizing, bottling, obtains powder of the present invention.
Embodiment 2:
(1) get Folium Callicarpae Formosanae 400g, Radix Sanguisorbae 300g, Lignum Dalbergiae Odoriferae 300g, Herba Corydalis Bungeanae 120g, Myrrha 155g, Herba Cirsii 180g, Radix Astragali 180g, Borneolum Syntheticum 50g, Radix Arnebiae (Radix Lithospermi) 30g, Radix Glycyrrhizae 25g respectively, drying and crushing, cross 150 mesh sieves.
(2) by the Chinese crude drug mixing after above-mentioned pulverizing, sterilizing, bottling, obtains powder of the present invention.
Embodiment 3:
(1) get Folium Callicarpae Formosanae 240g, Radix Sanguisorbae 400g, Lignum Dalbergiae Odoriferae 160g, Herba Corydalis Bungeanae 50g, Myrrha 80g, Herba Cirsii 200g, Radix Astragali 200g, Borneolum Syntheticum 10g, Radix Arnebiae (Radix Lithospermi) 10g, Radix Glycyrrhizae 40g respectively, drying and crushing, cross 100 mesh sieves.
(2) by the Chinese crude drug mixing after above-mentioned pulverizing, sterilizing, bottling, obtains powder of the present invention.
Embodiment 4:
(1) get Folium Callicarpae Formosanae 280g, Radix Sanguisorbae 400g, Lignum Dalbergiae Odoriferae 400g, Herba Corydalis Bungeanae 200g, Myrrha 200g, Herba Cirsii 200g, Radix Astragali 100g, Borneolum Syntheticum 50g, Radix Arnebiae (Radix Lithospermi) 30g, Radix Glycyrrhizae 20g respectively, drying and crushing, cross 150 mesh sieves.
(2) by the Chinese crude drug mixing after above-mentioned pulverizing, sterilizing, bottling, obtains powder of the present invention.
Clinical data:
1. physical data
Get in November ,-2015 in January, 2014 because of traumatic wound to our hospital patient 200 example, be divided into two groups at random: experimental group 150 example, 6 years old-72 years old age, 32 years old mean age.Wound length is less than 5cm person 92 example, and wound length is greater than 5cm person 58 example, and wound depth is person 96 example within 0.5cm, and wound depth is in 0.5cm-1.0cm person 54 example.Matched group 50 example, 5 years old-70 years old age, 32 years old mean age.Wound length is less than 5cm person 31 example, and wound length is greater than 5cm person 19 example, and wound depth is person 32 example within 0.5cm, and wound depth is in 0.5cm-1.0cm person 18 example.Above patient all bleeds because wound causes open wound, pain is gone to a doctor, and two groups of patient ages, wound classification, damage location, sewing needle number, wound degrees etc. compare, through X2 inspection, and there was no significant difference (P > 0.05).
2. Therapeutic Method:
Experimental group: after traumatic wound debridement and suturing, the powder embodiment of the present invention 1 prepared is sprinkling upon on wound equably, and thickness is advisable with 1mm-2mm, wrapping.Change dressings every day 1 time, until wound healing is taken out stitches.
Matched group: operate by traumatic wound nursing routine, after wound debridement and suturing, applies alcohol gauze, changes common aseptic medical dressing every day 1 time, until wound healing is taken out stitches.
3. experimental result:
3.1 liang of group hemostasis, detumescence, analgesic effects compare in table 1.
Table 1 liang group therapeutic effect
| Group | Number | Bleeding stopping period (h) | Swelling time (h) | Analgesic time (h) |
| Experimental group | 150 | 0.6±0.9 | 30.2±14.4 | 19.5±12.8 |
| Matched group | 50 | 2.8±1.5 | 121.2±20.3 | 72.1±20.5 |
The bleeding stopping period of visible test group, swelling time and analgesic time all have pole significant difference compared with matched group.
3.2 liang of group wound infections, wound healing situations compare in table 2.
Table 2 liang group wound infection, wound healing situation
| Group | Number | Wound infection | Primary healing | Secondary healing |
| Experimental group | 150 | 0 | 145 | 5 |
| Matched group | 50 | 10 | 30 | 10 |
Primary healing refers to that tissue repair is based on original cell, and only containing a small amount of fibrous tissue, local is without infecting, and hematoma or necrosis, tissue regeneration processes is rapid, and 26S Proteasome Structure and Function reparation is good.
Secondary healing refers to that tissue defect is large, edge of wound is not whole, trembles out, cannot be neatly involutory, or with the healing of the wound infected.
Show from table 2 experimental result, test group occurs without wound infection, and I phase healing rate can reach 96.7%, and matched group has 10 examples that wound infection occurs, and I phase healing rate is 60%.Meanwhile, experimental group patient only has individually slight cicatrix after healing, rarely has cicatrix to produce.And matched group generally leaves cicatrix, some patients leaves obvious cicatrix.
Above experimental result shows that the present invention promotes that the Chinese medicine of wound healing stops blooding, pain relieving, detumescence effect are more obvious, and the effect of bacteriostasis antibiosis, removing the necrotic tissue and promoting granulation is better, has the advantage not available for conventional medicament.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (4)
1. for a Chinese medicine preparation for wound process, it is characterized in that, be prepared from by the Chinese crude drug of following weight portion:
Folium Callicarpae Formosanae 200-400 part, Radix Sanguisorbae dry product 200-400 part, Lignum Dalbergiae Odoriferae 100-400 part, Herba Corydalis Bungeanae dry product 50-200 part, Myrrha 50-200 part, Herba Cirsii 50-200 part, Radix Astragali 50-200 part, Borneolum Syntheticum 10-50 part, Radix Arnebiae (Radix Lithospermi) 10-30 part, Radix Glycyrrhizae 20-40 part.
2., as claimed in claim 1 for the Chinese medicine preparation of wound process, it is characterized in that, be prepared from by the Chinese crude drug of following weight portion:
Folium Callicarpae Formosanae 300 parts, Radix Sanguisorbae dry product 300 parts, Lignum Dalbergiae Odoriferae 180 parts, Herba Corydalis Bungeanae dry product 100 parts, Myrrha 120 parts, Herba Cirsii 100 parts, the Radix Astragali 100 parts, Borneolum Syntheticum 40 parts, Radix Arnebiae (Radix Lithospermi) 12 parts, 20 parts, Radix Glycyrrhizae.
3., as claimed in claim 1 for the Chinese medicine preparation of wound process, it is characterized in that, be prepared from by the Chinese crude drug of following weight portion:
Folium Callicarpae Formosanae 400 parts, Radix Sanguisorbae dry product 300 parts, Lignum Dalbergiae Odoriferae 300 parts, Herba Corydalis Bungeanae dry product 120 parts, Myrrha 155 parts, Herba Cirsii 180 parts, the Radix Astragali 180 parts, Borneolum Syntheticum 50 parts, Radix Arnebiae (Radix Lithospermi) 30 parts, 25 parts, Radix Glycyrrhizae.
4., as claimed in claim 1 for the Chinese medicine preparation of wound process, it is characterized in that, be prepared from by the Chinese crude drug of following weight portion:
Folium Callicarpae Formosanae 240 parts, Radix Sanguisorbae dry product 400 parts, Lignum Dalbergiae Odoriferae 160 parts, Herba Corydalis Bungeanae dry product 50 parts, Myrrha 80 parts, Herba Cirsii 200 parts, the Radix Astragali 200 parts, Borneolum Syntheticum 10 parts, Radix Arnebiae (Radix Lithospermi) 10 parts, 40 parts, Radix Glycyrrhizae.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106728715A (en) * | 2016-12-10 | 2017-05-31 | 东莞小猕猴户外用品有限公司 | Outdoor full effect medicinal extract preparation method and outdoor full effect medicinal extract |
| CN111419952A (en) * | 2019-01-10 | 2020-07-17 | 黄佩强 | Traditional Chinese medicine composition with hemostatic and analgesic effects and preparation method and application thereof |
| CN114191496A (en) * | 2021-12-24 | 2022-03-18 | 江西积发医疗器械有限公司 | Hemostatic powder and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813751A (en) * | 2012-08-09 | 2012-12-12 | 张迎春 | Wound treatment agent |
| CN104524222A (en) * | 2015-01-19 | 2015-04-22 | 唐国萍 | Traditional Chinese medicine for promoting wound healing |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813751A (en) * | 2012-08-09 | 2012-12-12 | 张迎春 | Wound treatment agent |
| CN104524222A (en) * | 2015-01-19 | 2015-04-22 | 唐国萍 | Traditional Chinese medicine for promoting wound healing |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106728715A (en) * | 2016-12-10 | 2017-05-31 | 东莞小猕猴户外用品有限公司 | Outdoor full effect medicinal extract preparation method and outdoor full effect medicinal extract |
| CN111419952A (en) * | 2019-01-10 | 2020-07-17 | 黄佩强 | Traditional Chinese medicine composition with hemostatic and analgesic effects and preparation method and application thereof |
| CN111419952B (en) * | 2019-01-10 | 2022-08-02 | 黄佩强 | Traditional Chinese medicine composition with hemostatic and analgesic effects and preparation method and application thereof |
| CN114191496A (en) * | 2021-12-24 | 2022-03-18 | 江西积发医疗器械有限公司 | Hemostatic powder and preparation method thereof |
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Application publication date: 20160511 |