CN106620146A - Tampon for relieving and treating gynecological inflammations and preparation method of tampon - Google Patents
Tampon for relieving and treating gynecological inflammations and preparation method of tampon Download PDFInfo
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- A61K35/56—Materials from animals other than mammals
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- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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Abstract
The invention discloses a tampon for relieving and treating gynecological inflammations and a preparation method of the tampon. The tampon is prepared from loose cotton fiber, graphene and a traditional Chinese medicine composition extracting liquid in the weight ratio of 50: 1:3. The traditional Chinese medicine composition extracting liquid is prepared from cuttlebone, herba schizonepetae, fructus piperis longi, verbena officinalis, morinda officinalis, raspberry, herba lycopi and rhizoma dioscoreae colletii through extraction and concentration. The loose cotton fiber is placed in the traditional Chinese medicine composition extracting liquid after being pretreated with caustic soda to be soaked, freeze-dried and mixed with graphene, and a finished product is prepared after cotton mixing, blowing, carding and lapping. The tampon can dispel dampness, regulate menstruation, relieve pain and regulate immunity, is good in curative effect, high in cure rate, low in recurrence rate, safe and reliable, has no adverse effect after long-term usage, can significantly regulate gynecological intravaginal environment and is worthy using in clinical and daily caring.
Description
Technical field
The present invention relates to gyniatrics technical field, specifically a kind of tapon for alleviating and treating gynaecological imflammation
And preparation method thereof.
Background technology
Gynaecological imflammation is the common disease and frequently-occurring disease of women, and clinically common gynaecological imflammation has vaginitis, cervicitis, basin
Chamber inflammation and endometritis etc., gynaecological imflammation pathogenic factor complexity is various, and habits and customs weaker with itself physique and unclean etc. are close
Cut is closed;Count according to the World Health Organization, the whole world there are about 87% adult female and suffer from different degrees of gynaecological imflammation, China
70% married femle suffers from different degrees of gynaecological imflammation;In recent years, the illness rate of gynaecological imflammation is presented obvious ascendant trend,
Gynaecological imflammation not only causes greatly harm to the healthy of women, and infertile, ectopic pregnancy etc. is also resulted in when serious;Current woman
The general treatment means of section's inflammation are external application Western medicine, containing antibiotic or chemical disinfections such as metronidazole, clotrimazoles more than these medicines
Bactericide, Long-Time Service can cause certain infringement to organs such as liver kidneys, and easily make germ produce drug resistance, destroy vagina
Cause the mutual restricting relation between flora and cause flora imbalance, vagina is self-cleaning and defence capability for destruction, causes Relapse rate, no
Can thoroughly eradicate.
The content of the invention
It is an object of the invention to provide it is a kind of for alleviating and treating tapon of gynaecological imflammation and preparation method thereof,
Propose in solve the problems, such as above-mentioned background technology.
For achieving the above object, the present invention provides following technical scheme:
A kind of tapon for alleviating and treating gynaecological imflammation, is prepared from by the following raw material according to weight portion:Cotton dissipates
50 parts of fiber, 1 part of Graphene, 3 parts of traditional Chinese medicine composition extract liquid, the traditional Chinese medicine composition extract liquid is cuttlebone, ching-chieh, Bi
Jing is extracted and concentration is prepared after the roots of grass, Verbena officinalis, Morinda officinalis, raspberry, Herba Lycopi, Bi Collettii mixing.
As further scheme of the invention:The traditional Chinese medicine composition extract liquid is by the following raw material system according to weight portion
Into:Cuttlebone 10-20 parts, ching-chieh 10-20 parts, Bi roots of grass 5-15 parts, Verbena officinalis 5-15 parts, Morinda officinalis 4-10 parts, raspberry 1-5
Part, Herba Lycopi's 1-5 part, Bi Collettii 1-3 parts.
As further scheme of the invention:The traditional Chinese medicine composition extract liquid is by the following raw material system according to weight portion
Into:15 parts of cuttlebone, 15 parts of ching-chieh, 10 parts of the Bi roots of grass, 10 parts of Verbena officinalis, 7 parts of Morinda officinalis, 3 parts of raspberry, 3 parts of, Bi Collettiis of Herba Lycopi
2 parts.
As further scheme of the invention:The preparation side for alleviating and treating the tapon of gynaecological imflammation
Method, comprises the following steps:
1)The pretreatment of cotton staple in bulk:Cotton staple in bulk is weighed by formula ratio, 15 times of weight of cotton staple in bulk are squeezed into bleaching equipment
Soda bath, the mass percent concentration of soda bath is 15-20%, and process time is 30~40min;By the cotton after process
Staple in bulk lifting is boiled in yarn pot according to cotton staple in bulk into HTHP:Soft water=1:4~5 weight ratio carries out kiering, in soft water
Add the pectase and hemicellulase of its 0.05~0.1% weight;PH is adjusted between 7.0~7.6, kiering temperature is 60-80
℃;The kiering time is 1.5~2.5 hours;Then with 20 DEG C of intensification kierings per hour two hours;Take out the washing of cotton staple in bulk cold water
2~4 times, pH is adjusted between 6.6~7.4, squeeze moisture, obtain pretreated cotton staple in bulk;
2)The preparation of traditional Chinese medicine composition extract liquid:
2.1)Cuttlebone, ching-chieh, the Bi roots of grass, Verbena officinalis, Morinda officinalis, raspberry, Herba Lycopi's, Bi Collettiis are weighed by formula, is cleaned and is dried
It is standby;
2.2)Ching-chieh, Morinda officinalis, raspberry, Herba Lycopi are placed in Decocting pot, the purified water of 10 times of weight is added, are cooked by slow fire
2-3h, prepares aqueous extract;
2.3)By step 2.2)The aqueous extract concentration drying of middle preparation, obtains thick paste;
2.4)Cuttlebone, the Bi roots of grass, Verbena officinalis, Bi Collettiis are placed in extractor, 3-5 times of 95% ethanol measured are added, in 60-80 DEG C
Under the conditions of, refluxing extraction 2-3 time, each 45-60min collects ethanol extract;
2.5)By step 2.3)The thick paste of middle preparation is added to step 2.4)In the ethanol extract of preparation, 10- is sufficiently stirred for
15min reclaims ethanol to being completely dissolved, and freeze-drying is simultaneously crushed and obtains extract powder;
2.6)By step 2.5)The extract powder of middle preparation adds heating in the sterilized water of its 8-10 times of weight to redissolve, in obtaining
Medicament extracting solution;
3)Pretreated cotton staple in bulk is added in the Chinese medicine extract of formula ratio, constant temperature immersion 200-240min, immersion
Temperature maintains 35~45 DEG C;
4)By step 3)The cotton staple in bulk of middle immersion is taken out after freezing, and is mixed with the Graphene of formula ratio, Jing mixed cotton, blowing, comb
The tapon for alleviating and treating gynaecological imflammation is prepared after reason, lapping.
The pharmacological action of each medicine is as follows in the present invention:
1. cuttlebone:Taste is salty, puckery, warm in nature;Returns spleen, kidney channel;Astringing to arrest bleeding, relieving leukorrhea by astringents, relieving haperacidity, sore;For acid regurgitation of having a stomachache,
Hematemesis and epistaxis, uterine bleeding is had blood in stool, emission and spermatorrhea, leukorrhea with reddish discharge;Canker;Bleeding due to trauma, many pus of sore are controlled outward;There is promotion inflammation fast
Speed absorbs and accelerates the effect of wound healing.
2. ching-chieh:Taste is pungent, slightly warm in nature;Return lung, Liver Channel;Dispelling wind and relieving, apocenosis is sensible, induce sweat scattered wind, promoting eruption, and disappear sore;
For catching a cold, headache, measles, rubella, sore from the beginning of;Containing volatile oil, main component is D-menthone, racemization menthones, Hu
Green pepper ketone, d-limonen etc.;Also contain cyanidenon, apiolin, trans isomer cinnamic acid, cupreol, ursolic acid, aurantiamarin, 3-
Hydroxyl -4(8)- alkene-P- terpanes -3(9)- lactone, hesperetin -7-0- glucosides;With film fusion is suppressed, with anti-
Inflammation, analgesia, spasmolysis, anti-ulcer effect, can regulating blood condition hemostasis;Modern pharmacological research proves, can strengthen skin blood and circulate, increases
Sweat gland secretion, there is obvious anticomplementary action.
3. the Bi roots of grass:Taste is pungent, property heat;Return stomach, large intestine channel;Warming spleen and stomach for dispelling cold, lower gas pain relieving;For coldness and pain in the epigastrium, vomiting, let out
Rush down, cold obstruction causing qi stagnation, chest impediment and cardialgia, have a headache, toothache;Fruit contains pipering, palmitic acid, tetrahydropiperic acid, 1- undecenyl -3,
4- methylene dioxy benzene, piperidines, volatile oil;The Bi roots of grass also decadinene of isobutyl group containing N-(Trans- 2, trans- 4)Acid amides, sesamin;During Bi is dialled
The essential oil of proposition is equal to white and staphylococcus aureus and hay bacillus, Bacillus cereus, Escherichia coli, shigella dysenteriae etc.
There is inhibitory action;Pipering has destruction to the nerve and musculature of housefly.
4. Verbena officinalis:Bitter, cold in nature, Return liver, the spleen channel;Herb contains verbenalin, tannin, volatile oil, and root and stem kind are aqueous
Threose, leaf kind is containing adenosine and B-carrotene;Herb hyoscine, cool in nature, the micro- Wei of taste, have cool blood, dissipate the stasis of blood, stimulate the menstrual flow, heat-clearing, solution
Malicious, antipruritic, expelling parasite, effect of dissipate-swelling;It is clearing heat and detoxicating, promoting blood circulation to remove blood stasis, inducing diuresis for removing edema;Control fever caused by exogenous pathogens, jaundice with damp-heat pathogen, oedema,
Dysentery, malaria, diphtheria, larynx numbness, gonorrhoea, Amenorrhea, abdominal mass, carbuncle sore tumefacting virus, noma.
5. Morinda officinalis:Labiatae Rabdosia, bitter is sweet;Cold nature;Clearing heat and detoxicating, promoting blood circulation and stopping pain;Cure mainly throat to swell
Bitterly, cold headache, tracheitis, chronic hepatitis, rheumatic arthritis, snake bite and insect sting;Have good heat-clearing poison, promoting blood circulation and stopping pain, it is antibacterial,
Antitumor action;Rabdosia rubescens contains Oridonin, rubescensine B and Rosmarinic acid, Oridonin, rubescensine B tool
There is antitumaous effect, symptom effect is relieved to primary carcinoma of liver, have stable and reduce knurl body and extend the effect of patients ' lives
Really;Rabdosia rubescens has obvious synergistic effect with chemotherapy, other cancer therapy drug partner treatment cancers;Good antimicrobial effect, Rabdosia rubescens
Decoction and alcohol agent can effectively suppress A type and beta hemolytic streptococcus, staphylococcus aureus etc., improve human body opposing
Power is rapid to reduce because the white blood cell that inflammation causes increases.
6. raspberry:It is sweet, sour, warm in nature, Return liver, kidney, bladder warp;Containing organic acid, carbohydrate and a small amount of vitamin C and
The acid of gallic acid, cupreol and raspberry;With brain tonic and intelligence development, beautifying face and moistering lotion, anti-curing cancers effect;Containing flavonoids thing
Matter, with anti-inflammation, reduces blood pressure and antianaphylactic effect;Containing anthocyanin, free radical can be removed, it is anti-oxidant.
7. Herba Lycopi:It is bitter, pungent;Slightly warm in nature;Return liver, the spleen channel;Promoting blood circulation for regulating menstruation, dissolving stasis disappear carbuncle, inducing diuresis for removing edema;For menstruation not
Adjust, Amenorrhea, dysmenorrhoea, postpartum blood stasis stomachache, sore and toxic, oedema ascites;The hydrochloric atisine of root, talaisamine, gymnaconitine, methyl
Gymnaconitine;Its main chemical compositions spreads gymnaconitine, methyl gymnaconitine and c based on Aconitine-type amine alcohol class and its monoesters class
One diterpene alkaloid;Containing volatile oil, glycoside, tannin and resin, also containing glycosides displayed, phenols, amino acid, organic acid, saponin,
Glucose, galactolipin, Herba Lycopi's sugar, sucrose, gossypose, stachyose, fructose.Fruit containing glucose, galactolipin, Herba Lycopi's sugar, sucrose,
Gossypose, stachyose.
8. Bi Collettii:Bitter, it is mild-natured;Return kidney, stomach;Dampness removing removes turbid, wind expelling stagnation removing;Drench for cream, gonorrhoea, leukorrhea,
Arthralgia due to wind-dampness, articular instability, lumbocrural pain;Containing Dioscin, still containing gracillin, dioscoreassapotoxin A;There is insecticidal and antibacterial
Effect;There is therapeutic action to the experimental atherosclerosis of rabbit.Its saponin have plan choline-like effect, can expand peripheral vessel,
Reduce blood pressure, strengthen the motion of gastrointestinal smooth muscle, and can rise hyperglycaemia, the chemically convulsions to anti-mouse, and improves rat
The permeability of the various tissues such as stomach and intestine.
Compared with prior art, the invention has the beneficial effects as follows:The tapon of the present invention is by adding Chinese medicine composition
Extract, the characteristics of with " Mutiple Targets, manifold effect ", the selected medicinal material compatibility of the present invention is suitable, meets traditional Chinese medicine and pharmacy and modern doctor
Pharmaceutical theory, scientific formulation, simple with dialectical treatmert as this, selected medicine medicine source is wide, with low cost;Cuttlebone, the Bi roots of grass, bar
Halberd day is monarch drug in a prescription, and Verbena officinalis, ching-chieh are ministerial drug, and raspberry, Herba Lycopi are adjutant , Bi Collettiis to make medicine, all medicine combinations play clearing damp altogether
Pain relieving, the effect of menstruction regulating and pain relieving;With controlling, clear benefit combines qi and blood, and detoxification and removing stasis are same to be applied;With the effect for adjusting immunity, therapeutic effect is good,
Cure rate is high, effectively reduces gynaecological imflammation recurrence rate, safe and reliable, without any side effects, reduces patient in therapeutic process
In bad reaction, short treating period, instant effect, with removing toxic substances analgesia, the effect taken good care of of tonifying Qi;Can reduction of patient pain, reach and control
Heading, can fundamentally reduce inflammation reaction again, prevent disease progression, the stable state of an illness from effect of effecting a permanent cure being reached, so as to reach mark
This simultaneous purpose controlled, Long-Time Service has no adverse reaction, and can significantly adjust environment in gynaecologic vaginal, and clinic and daily nursing make
With.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than the embodiment of whole.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of tapon for alleviating and treating gynaecological imflammation, is prepared from by the following raw material according to weight portion:Cotton dissipates
50 parts of fiber, 1 part of Graphene, 3 parts of traditional Chinese medicine composition extract liquid, the traditional Chinese medicine composition extract liquid according to weight portion composition
For:10 parts of cuttlebone, 10 parts of ching-chieh, 5 parts of the Bi roots of grass, 5 parts of Verbena officinalis, 4 parts of Morinda officinalis, 1 part of raspberry, 1 part of, Bi Collettii 3 of Herba Lycopi
Part.
The preparation method for alleviating and treating the tapon of gynaecological imflammation, comprises the following steps:
1)The pretreatment of cotton staple in bulk:Cotton staple in bulk is weighed by formula ratio, 15 times of weight of cotton staple in bulk are squeezed into bleaching equipment
Soda bath, the mass percent concentration of soda bath is 15-20%, and process time is 30~40min;By the cotton after process
Staple in bulk lifting is boiled in yarn pot according to cotton staple in bulk into HTHP:Soft water=1:4~5 weight ratio carries out kiering, in soft water
Add the pectase and hemicellulase of its 0.05~0.1% weight;PH is adjusted between 7.0~7.6, kiering temperature is 60-80
℃;The kiering time is 1.5~2.5 hours;Then with 20 DEG C of intensification kierings per hour two hours;Take out the washing of cotton staple in bulk cold water
2~4 times, pH is adjusted between 6.6~7.4, squeeze moisture, obtain pretreated cotton staple in bulk;
2)The preparation of traditional Chinese medicine composition extract liquid:
2.1)Cuttlebone, ching-chieh, the Bi roots of grass, Verbena officinalis, Morinda officinalis, raspberry, Herba Lycopi's, Bi Collettiis are weighed by formula, is cleaned and is dried
It is standby;
2.2)Ching-chieh, Morinda officinalis, raspberry, Herba Lycopi are placed in Decocting pot, the purified water of 10 times of weight is added, are cooked by slow fire
2-3h, prepares aqueous extract;
2.3)By step 2.2)The aqueous extract concentration drying of middle preparation, obtains thick paste;
2.4)Cuttlebone, the Bi roots of grass, Verbena officinalis, Bi Collettiis are placed in extractor, 3-5 times of 95% ethanol measured are added, in 60-80 DEG C
Under the conditions of, refluxing extraction 2-3 time, each 45-60min collects ethanol extract;
2.5)By step 2.3)The thick paste of middle preparation is added to step 2.4)In the ethanol extract of preparation, 10- is sufficiently stirred for
15min reclaims ethanol to being completely dissolved, and freeze-drying is simultaneously crushed and obtains extract powder;
2.6)By step 2.5)The extract powder of middle preparation adds heating in the sterilized water of its 8-10 times of weight to redissolve, in obtaining
Medicament extracting solution;
3)Pretreated cotton staple in bulk is added in the Chinese medicine extract of formula ratio, constant temperature immersion 200-240min, immersion
Temperature maintains 35~45 DEG C;
4)By step 3)The cotton staple in bulk of middle immersion is taken out after freezing, and is mixed with the Graphene of formula ratio, Jing mixed cotton, blowing, comb
The tapon for alleviating and treating gynaecological imflammation is prepared after reason, lapping.
Embodiment 2
A kind of tapon for alleviating and treating gynaecological imflammation, is prepared from by the following raw material according to weight portion:Cotton dissipates
50 parts of fiber, 1 part of Graphene, 3 parts of traditional Chinese medicine composition extract liquid, the traditional Chinese medicine composition extract liquid according to weight portion composition
For:15 parts of cuttlebone, 15 parts of ching-chieh, 10 parts of the Bi roots of grass, 10 parts of Verbena officinalis, 7 parts of Morinda officinalis, 3 parts of raspberry, 3 parts of, Bi Collettiis of Herba Lycopi
2 parts.
The preparation method for alleviating and treating the tapon of gynaecological imflammation, comprises the following steps:
1)The pretreatment of cotton staple in bulk:Cotton staple in bulk is weighed by formula ratio, 15 times of weight of cotton staple in bulk are squeezed into bleaching equipment
Soda bath, the mass percent concentration of soda bath is 15-20%, and process time is 30~40min;By the cotton after process
Staple in bulk lifting is boiled in yarn pot according to cotton staple in bulk into HTHP:Soft water=1:4~5 weight ratio carries out kiering, in soft water
Add the pectase and hemicellulase of its 0.05~0.1% weight;PH is adjusted between 7.0~7.6, kiering temperature is 60-80
℃;The kiering time is 1.5~2.5 hours;Then with 20 DEG C of intensification kierings per hour two hours;Take out the washing of cotton staple in bulk cold water
2~4 times, pH is adjusted between 6.6~7.4, squeeze moisture, obtain pretreated cotton staple in bulk;
2)The preparation of traditional Chinese medicine composition extract liquid:
2.1)Cuttlebone, ching-chieh, the Bi roots of grass, Verbena officinalis, Morinda officinalis, raspberry, Herba Lycopi's, Bi Collettiis are weighed by formula, is cleaned and is dried
It is standby;
2.2)Ching-chieh, Morinda officinalis, raspberry, Herba Lycopi are placed in Decocting pot, the purified water of 10 times of weight is added, are cooked by slow fire
2-3h, prepares aqueous extract;
2.3)By step 2.2)The aqueous extract concentration drying of middle preparation, obtains thick paste;
2.4)Cuttlebone, the Bi roots of grass, Verbena officinalis, Bi Collettiis are placed in extractor, 3-5 times of 95% ethanol measured are added, in 60-80 DEG C
Under the conditions of, refluxing extraction 2-3 time, each 45-60min collects ethanol extract;
2.5)By step 2.3)The thick paste of middle preparation is added to step 2.4)In the ethanol extract of preparation, 10- is sufficiently stirred for
15min reclaims ethanol to being completely dissolved, and freeze-drying is simultaneously crushed and obtains extract powder;
2.6)By step 2.5)The extract powder of middle preparation adds heating in the sterilized water of its 8-10 times of weight to redissolve, in obtaining
Medicament extracting solution;
3)Pretreated cotton staple in bulk is added in the Chinese medicine extract of formula ratio, constant temperature immersion 200-240min, immersion
Temperature maintains 35~45 DEG C;
4)By step 3)The cotton staple in bulk of middle immersion is taken out after freezing, and is mixed with the Graphene of formula ratio, Jing mixed cotton, blowing, comb
The tapon for alleviating and treating gynaecological imflammation is prepared after reason, lapping.
Embodiment 3
As further scheme of the invention:The traditional Chinese medicine composition extract liquid is made up of the following raw material according to weight portion:Sea
20 parts of the egg capsule of a mantis, 20 parts of ching-chieh, 15 parts of the Bi roots of grass, 15 parts of Verbena officinalis, 10 parts of Morinda officinalis, 5 parts of raspberry, 5 parts of Herba Lycopi, 3 parts of, Bi Collettiis.
The preparation method for alleviating and treating the tapon of gynaecological imflammation, comprises the following steps:
1)The pretreatment of cotton staple in bulk:Cotton staple in bulk is weighed by formula ratio, 15 times of weight of cotton staple in bulk are squeezed into bleaching equipment
Soda bath, the mass percent concentration of soda bath is 15-20%, and process time is 30~40min;By the cotton after process
Staple in bulk lifting is boiled in yarn pot according to cotton staple in bulk into HTHP:Soft water=1:4~5 weight ratio carries out kiering, in soft water
Add the pectase and hemicellulase of its 0.05~0.1% weight;PH is adjusted between 7.0~7.6, kiering temperature is 60-80
℃;The kiering time is 1.5~2.5 hours;Then with 20 DEG C of intensification kierings per hour two hours;Take out the washing of cotton staple in bulk cold water
2~4 times, pH is adjusted between 6.6~7.4, squeeze moisture, obtain pretreated cotton staple in bulk;
2)The preparation of traditional Chinese medicine composition extract liquid:
2.1)Cuttlebone, ching-chieh, the Bi roots of grass, Verbena officinalis, Morinda officinalis, raspberry, Herba Lycopi's, Bi Collettiis are weighed by formula, is cleaned and is dried
It is standby;
2.2)Ching-chieh, Morinda officinalis, raspberry, Herba Lycopi are placed in Decocting pot, the purified water of 10 times of weight is added, are cooked by slow fire
2-3h, prepares aqueous extract;
2.3)By step 2.2)The aqueous extract concentration drying of middle preparation, obtains thick paste;
2.4)Cuttlebone, the Bi roots of grass, Verbena officinalis, Bi Collettiis are placed in extractor, 3-5 times of 95% ethanol measured are added, in 60-80 DEG C
Under the conditions of, refluxing extraction 2-3 time, each 45-60min collects ethanol extract;
2.5)By step 2.3)The thick paste of middle preparation is added to step 2.4)In the ethanol extract of preparation, 10- is sufficiently stirred for
15min reclaims ethanol to being completely dissolved, and freeze-drying is simultaneously crushed and obtains extract powder;
2.6)By step 2.5)The extract powder of middle preparation adds heating in the sterilized water of its 8-10 times of weight to redissolve, in obtaining
Medicament extracting solution;
3)Pretreated cotton staple in bulk is added in the Chinese medicine extract of formula ratio, constant temperature immersion 200-240min, immersion
Temperature maintains 35~45 DEG C;
4)By step 3)The cotton staple in bulk of middle immersion is taken out after freezing, and is mixed with the Graphene of formula ratio, Jing mixed cotton, blowing, comb
The tapon for alleviating and treating gynaecological imflammation is prepared after reason, lapping.
Pharmaceutical composition efficiency of the present invention is described further with reference to clinical testing:
1)Experimental subjects
Take from 33 gynaecology patients of somewhere A hospitals, 75 gynaecology patients of B hospitals, 108 altogether, because some patients are
The illness of several gynecological diseases occurs simultaneously, therefore statistics is 123, in above-mentioned gynaecology patient, the menopause of -64 years old 48 years old
Phase women 9, remaining is young women;The course of disease more than 1 year 27,17 of-one year half a year, the 14 of three months-half a year
Example, one month-trimestral 15,35 of less than one month;In above-mentioned gynaecology patient, its gynecological diseases includes vagina
Inflammation, vulvitis, eczema, ulcus vulvae, leukoplakia vulvae, vulva and pruritus ani, cervical erosion, condyloma acuminatum etc.;Wherein,
Vaginitis includes vulvovaginitis, colpitis simplex, senile vahinitis, atrophic vaginitis, colpomycosis and drop
Worm property vaginitis;Cervical erosion includes I degree and II degree two kinds;Eczema includes two kinds of vulva and anus.
2)Experiment material:Three groups of experimental groups are respectively with tapon prepared by embodiment 1-3;
3)Method and curative effect determinate standard
3.1)Method
Sufferer is divided at random three groups, and each group illness and the course of disease are similar, with comparativity;Sufferer changed a cotton wool per 1 day
Bar, 3-5 days is a course for the treatment of, and mild patient uses 1 course for the treatment of;Moderate symptoms patient uses 2 courses for the treatment of;Severe symptomatic is suffered from
Person uses the 3-6 course for the treatment of.
3.2)Curative effect determinate standard
Recovery from illness:Clinical symptoms, sign are wholly absent, and laboratory examination switchs to normal person;
It is effective:Clinical symptoms, sign are wholly absent or compared with the person of being clearly better before treating, and laboratory examination does not switch to completely yet normally
Person;
Effectively:Clinical symptoms, sign take a turn for the better before relatively treating, but not yet reach the person of being clearly better;
It is invalid:Clinical symptoms, sign relatively treat front without improvement person, indivedual even relatively to treat front plus severe one.
4)Observation of curative effect
In 33 of A hospitals observation, vulvitis 5, effective 4;Vaginitis 11, fully recovers 6, effective 4, effective 1;Outward
Cloudy convulsion is itched 3, effective 3;Leukoplakia vulvae 5, effective 4, effective 1;Cervical erosion 2, effective 2;Ulcus vulvae 1
Example, effective 1;Sharp wet defect 6, effective 6.
In 75, B hospitals, vulvitis 11 is fully recovered 8, effective 3;Vaginitis 27, fully recovers 20, effective 5, has
Effect 2;Vulva and anus convulsion are itched 16, are fully recovered 9, effective 6, effective 2, wherein, vulva convulsion itches+and uterine neck convulsion itches+annex
Scorching 1 is effectively, vulva convulsion itches+leukoplakia vulvae 1 effectively;Leukoplakia vulvae 3, effective 3;Cervical erosion 13, effective 7,
Effective 6, wherein, colpitis simplex and cervical erosion 9, effective 6;Ulcus vulvae 1, effective 1;Eczema of vulva,
Vulva condyloma it is each 2 it is effective.
After above-mentioned patient is generally reflected using embodiment of the present invention 1-3 tapon, locally feel comfortably cool, breathe freely, and burn
Burn, convulsion gargalesthesia substantially mitigates quickly or disappears, secretion is significantly reduced or disappeared.
Model case:
1. Qin, 30 years old, main suit's menopause 40 days, leukorrhea is more, and vulva convulsion is itched 1 week;Gynaecological examination:Vagina leukorrhea is more, in yellow foam,
Corpus uteri anteposition slightly increases, remaining (one).Chemical examination:Leukorrhea finds trichomonad, II ° of cleannes;Diagnosis:Trichomonas vaginitis, early pregnancy.Make
1 course for the treatment of of tapon prepared with embodiment 1, once a day, pruritus vulvae is stopped, and yellowish leukorrhea turns white amount less, I ° of cleannes.
2. beam, 34 years old, main suit have a bath after pruritus vulvae, leukorrhea is more 2 days;Gynaecological examination:Intravaginal leukorrhea is more, in bulk, uterine neck light
It is sliding congested, remaining (one);Chemical examination:Leukorrhea finds mould, II ° of cleannes;Diagnosis:Colpomycosis;Prepared using embodiment 2
1 course for the treatment of of tapon, once a day, pruritus vulvae is stopped, and leukorrhea amount turns few, I ° of cleannes.
3. Xu certain, 24 years old, main suit leukorrhea was more, itching of vulva 3 days;Gynaecological examination:Introitus is congested, remaining (one);Chemical examination:Leukorrhea cleans
I ° of degree, it is without exception.Diagnosis:Pruritus vulvue, the tapon prepared using embodiment 32 times, pruritus vulvae is disappeared, and leukorrhea is reduced.
4. Dong, 53 years old, main suit's menopause 1 year half, pruritus vulvue 2 weeks.Gynaecological examination:Atrophy of vulva, vagina is congested, remaining (one);
Diagnosis:Senile vahinitis, 2 courses for the treatment of of tapon prepared using embodiment 2, once a day, itching of vulva disappears, cloudy
Road hyperemia is clearly better.
5. Cai, 30 years old, main suit leukorrhea was more, itching of vulva January;Gynaecological examination:The false point wart substrate of intravaginal remaining;Diagnosis:False point
Wart;1 course for the treatment of of tapon prepared using embodiment 2, once a day, pudendum cleaning is dried, conscious more to use more comfortable.
6. side, 36 years old, main suit's vulva sore 10 days;Gynaecological examination:Vulva is red and swollen, and there are one 1. 2*0. 2cm labia majora inner side
Ulcer.Intravaginal leukorrhea is more, and uterine neck is smooth, palace body anteposition, remaining (one);Chemical examination:Leukorrhea is normal;Diagnosis:Ulcus vulvae;Using reality
1 course for the treatment of of tapon of the preparation of example 1 is applied, once a day, redness disappears, and ulcer surface is obviously reduced to the 1cm of 0. 1 * 0..
7. Huang, 30 years old, main suit leukorrhea many March, lower abdomen was uncomfortable;Gynaecological examination:How athero- intravaginal leukorrhea is;I ° of gruel of uterine neck
It is rotten, position after corpus uteri, remaining (one);Chemical examination:II ° of leukorrhea cleannes;Diagnosis:I °+colpitis simplex of cervical erosion.Using enforcement
2 courses for the treatment of of tapon prepared by example 1, once a day, leukorrhea is reduced, and lower abdomen is uncomfortable to take a turn for the better, and cervical erosion takes a turn for the better, and looks into leukorrhea
Cleannes I °.
Tapon prepared by embodiment of the present invention 1-3, effective ingredient passes through direct skin contact in tapon
Wound location, medicine readily penetrates through skin, and therapeutic action is reached into blood circulation;Percutaneous dosing can be without liver
" first pass effect " and GI destruction, and skin interbed also has storage to act on, and makes drug concentration profile gentle, it is to avoid " peak
Lasting blood concentration is stablized in paddy phenomenon ", there is provided action time that can be predetermined and longer, maintenance, and toxicity and bad reaction are little,
It is easy to use;This makes therapeutic process more safely and effectively highly beneficial for the side effect for reducing gynaecological disease treatment;The present invention's
Tapon, directly can be delivered to diseased region by intravaginal mucosal tissue by active ingredient, thoroughly kill and cause vagina
Scorching, vulva and eczema of anus, vulva and anus convulsion are itched, ulcus vulvae, pelvic infecton, adnexitis, cervicitis and cervical erosion, vulva
The gynopathic pathogenic microorganisms such as white lesions, condyloma acuminatum, gonorrhoea gynecological infection, it is rapid eliminate or alleviate convulsion itch, peculiar smell, point
Secretion exception, can effectively alleviate and treat various gynecological diseases, and with rapid-action, short treating period, efficacy stability, safety is without secondary work
Advantage.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of spirit or essential attributes without departing substantially from the present invention, the present invention can be in other specific forms realized.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit is required rather than described above is limited, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although this specification is been described by according to embodiment, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity those skilled in the art should
Using specification as an entirety, the technical scheme in each embodiment can also Jing it is appropriately combined, form those skilled in the art
Understandable other embodiment.
Claims (4)
1. a kind of tapon for alleviating and treating gynaecological imflammation, it is characterised in that by the following raw material according to weight portion
It is prepared from:50 parts of cotton staple in bulk, 1 part of Graphene, 3 parts of traditional Chinese medicine composition extract liquid, the traditional Chinese medicine composition extract liquid is sea
Jing is extracted and concentration is prepared after the egg capsule of a mantis, ching-chieh, the Bi roots of grass, Verbena officinalis, Morinda officinalis, raspberry, Herba Lycopi, Bi Collettii mixing.
2. the tapon for alleviating and treating gynaecological imflammation according to claim 1, it is characterised in that the Chinese medicine
Composition extract is made up of the following raw material according to weight portion:Cuttlebone 10-20 parts, ching-chieh 10-20 parts, Bi roots of grass 5-15
Part, Verbena officinalis 5-15 parts, Morinda officinalis 4-10 parts, raspberry 1-5 parts, Herba Lycopi's 1-5 part, Bi Collettii 1-3 parts.
3. the tapon for alleviating and treating gynaecological imflammation according to claim 2, it is characterised in that the Chinese medicine
Composition extract is made up of the following raw material according to weight portion:15 parts of cuttlebone, 15 parts of ching-chieh, 10 parts of the Bi roots of grass, Verbena officinalis
10 parts, 7 parts of Morinda officinalis, 3 parts of raspberry, 3 parts of Herba Lycopi, 2 parts of, Bi Collettiis.
4. a kind of preparation method for alleviating and treating the tapon of gynaecological imflammation as described in claim 1-2 is arbitrary,
Characterized in that, comprising the following steps:
1)The pretreatment of cotton staple in bulk:Cotton staple in bulk is weighed by formula ratio, 15 times of weight of cotton staple in bulk are squeezed into bleaching equipment
Soda bath, the mass percent concentration of soda bath is 15-20%, and process time is 30~40min;By the cotton after process
Staple in bulk lifting is boiled in yarn pot according to cotton staple in bulk into HTHP:Soft water=1:4~5 weight ratio carries out kiering, in soft water
Add the pectase and hemicellulase of its 0.05~0.1% weight;PH is adjusted between 7.0~7.6, kiering temperature is 60-80
℃;The kiering time is 1.5~2.5 hours;Then with 20 DEG C of intensification kierings per hour two hours;Take out the washing of cotton staple in bulk cold water
2~4 times, pH is adjusted between 6.6~7.4, squeeze moisture, obtain pretreated cotton staple in bulk;
2)The preparation of traditional Chinese medicine composition extract liquid:
2.1)Cuttlebone, ching-chieh, the Bi roots of grass, Verbena officinalis, Morinda officinalis, raspberry, Herba Lycopi's, Bi Collettiis are weighed by formula, is cleaned and is dried
It is standby;
2.2)Ching-chieh, Morinda officinalis, raspberry, Herba Lycopi are placed in Decocting pot, the purified water of 10 times of weight is added, are cooked by slow fire
2-3h, prepares aqueous extract;
2.3)By step 2.2)The aqueous extract concentration drying of middle preparation, obtains thick paste;
2.4)Cuttlebone, the Bi roots of grass, Verbena officinalis, Bi Collettiis are placed in extractor, 3-5 times of 95% ethanol measured are added, in 60-80 DEG C
Under the conditions of, refluxing extraction 2-3 time, each 45-60min collects ethanol extract;
2.5)By step 2.3)The thick paste of middle preparation is added to step 2.4)In the ethanol extract of preparation, 10- is sufficiently stirred for
15min reclaims ethanol to being completely dissolved, and freeze-drying is simultaneously crushed and obtains extract powder;
2.6)By step 2.5)The extract powder of middle preparation adds heating in the sterilized water of its 8-10 times of weight to redissolve, in obtaining
Medicament extracting solution;
3)Pretreated cotton staple in bulk is added in the Chinese medicine extract of formula ratio, constant temperature immersion 200-240min, immersion
Temperature maintains 35~45 DEG C;
4)By step 3)The cotton staple in bulk of middle immersion is taken out after freezing, and is mixed with the Graphene of formula ratio, Jing mixed cotton, blowing, comb
The tapon for alleviating and treating gynaecological imflammation is prepared after reason, lapping.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109589443A (en) * | 2018-12-13 | 2019-04-09 | 湖南千金卫生用品股份有限公司 | A kind of analgesic tapon and preparation method thereof |
GB2623366A (en) * | 2022-10-14 | 2024-04-17 | Liberum Health Ltd | Drug delivery device |
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CN105879106A (en) * | 2016-05-03 | 2016-08-24 | 腾科宝迪(厦门)生物科技有限公司 | Graphene medical cotton and preparation method thereof |
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2017
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CN105879106A (en) * | 2016-05-03 | 2016-08-24 | 腾科宝迪(厦门)生物科技有限公司 | Graphene medical cotton and preparation method thereof |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109589443A (en) * | 2018-12-13 | 2019-04-09 | 湖南千金卫生用品股份有限公司 | A kind of analgesic tapon and preparation method thereof |
CN109589443B (en) * | 2018-12-13 | 2021-11-16 | 湖南千金卫生用品股份有限公司 | Pain-relieving sanitary cotton strip and preparation method thereof |
GB2623366A (en) * | 2022-10-14 | 2024-04-17 | Liberum Health Ltd | Drug delivery device |
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