CN109010685A - A kind of gynaecology's antibacterial foam aerosol and preparation method thereof - Google Patents
A kind of gynaecology's antibacterial foam aerosol and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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Abstract
The present invention provides a kind of gynaecology's antibacterial foam aerosol and preparation method thereof, belongs to gynecopathy therapeutic technical field.The antibacterial foam aerosol of the gynaecology includes following raw material: 3-13 parts of Cortex Phellodendri, 4-10 parts of kuh-seng, 4-10 parts of frutus cnidii, 4-10 parts of the tuber of stemona, 1-8 parts of safflower, 1-5 parts of aloe, 1-5 parts of silk peptide, 1-5 parts of oil of zedoary turmeric, 0.1-1 parts of borneol, 0.1-1 parts of antibacterial agent, 0.1-1 parts of Rosa Damascana, 7-20 parts of surfactant, 0.1-1 parts of ethyl alcohol, 0.1-1 parts of lactic acid, 0.6-1.4 parts of cosolvent as unit of parts by weight.Traditional Chinese medicinal aerosol prepared by the present invention have sterilization, it is anti-inflammatory, antiviral, to gynaecological imflammation caused by bacterium, mould, fungi, trichomonad, itch, peculiar smell etc. all has ideal effect, can be used to gynecological disease prevent, treat and disinfecting health care.
Description
Technical field
The invention belongs to gynecopathy therapeutic technical fields, and in particular to a kind of gynaecology antibacterial foam aerosol and its system
Preparation Method.
Background technique
Gynecological disease such as vaginitis is usually some common frequently-occurring diseases, usually and obstinate, to normal life,
Work belt is come greatly inconvenient.Vaginitis is clinically changed using the character of leukorrhea and vulva ulcer itches cusalgia as Major Clinical
Feature, intercourse pain is also common, when urethra is involved in infection, can there is the symptoms such as urodynia, urgent urination, vaginitis has morbidity slowly, repeatability
By force, the difficult thorough feature for the treatment of.Clinic mostly uses part and/or whole body application antibiotic and/or azoles to the treatment of vaginitis at present
Class antifungal, curative effect affirmative, but vaginitis easily recurs, and the vaginitis patient after recurrence needs Long-term Oral antifungal drug,
Easily damage liver, while other side effects are also apparent from such as gastrointestinal discomfort, headache and flushed face, gravid woman are vaginitis
One of good hair crowd, still can not rule out the possibility for increasing monster and stillborn foetus incidence using antifungal drug, therefore antifungal
Object is not received mostly by Pregnancy vaginitis patient, while using Chinese medicine or Western medicine antibacterial, sterilization, anti-inflammatory merely, toxic side effect is big,
Long-term effect is bad, and the profitable strain of intravaginal has easily been killed while anti-inflammatory sterilization, destroys the normal bacterium of intravaginal
Group's balance, leads to the generation of other vaginal diseases, or lead to the recurrent exerbation of inflammation, and the time for the treatment of and rehabilitation can be long.
Traditional Chinese medicine treatment atrophic vaginitis has its unique advantage, have in recent years the drugs of many treatment vaginitis with
Clearing heat and detoxicating, dampness removing dissipating bind, desinsection are antipruritic, promoting the circulation of qi broken stasis of blood is method, based on heat-clearing and detoxifying drug, its standard card of primary treatment, and mesh
The preceding drug for treating vaginitis in the market, the mostly form directly to sterilize, anti-inflammatory is in the majority, prevents and treats the effect of vaginitis and pays no attention to
Think.
Summary of the invention
The present invention solves and presses down in the prior art by providing a kind of gynaecology's antibacterial foam aerosol and preparation method thereof
The bad technical problem of the fungistatic effect of bacterium drug, the present invention have the function of sterilization, anti-inflammatory, antiviral etc., to bacterium, mould,
Gynaecological imflammation caused by fungi, trichomonad, itch, peculiar smell etc. all have comparatively ideal effect.
To achieve the above object, the technical solution of the invention is as follows:
A kind of antibacterial foam aerosol of gynaecology includes following raw material: 3-13 parts of Cortex Phellodendri, kuh-seng 4- as unit of parts by weight
10 parts, 4-10 parts of frutus cnidii, 4-10 parts of the tuber of stemona, 1-8 parts of safflower, 1-5 parts of aloe, 1-5 parts of silk peptide, 1-5 parts of oil of zedoary turmeric, borneol
0.1-1 parts, 0.1-1 parts of antibacterial agent, 0.1-1 parts of Rosa Damascana, 7-20 parts of surfactant, 0.1-1 parts of ethyl alcohol, lactic acid 0.1-1
Part, 0.6-1.4 parts of cosolvent.
Preferably, as unit of parts by weight include following raw material: 8 parts of Cortex Phellodendri, 6 parts of kuh-seng, 7 parts of frutus cnidii, 5 parts of the tuber of stemona,
5 parts of safflower, 3 parts of aloe, 3 parts of silk peptide, 3 parts of oil of zedoary turmeric, 0.5 part of borneol, 0.6 part of antibacterial agent, 0.4 part of Rosa Damascana, surface are living
Property 15 parts of agent, 0.6 part of ethyl alcohol, 0.7 part of lactic acid, 1 part of cosolvent.
Preferably, the surfactant is Tween 80, alkyl glycosides, sodium cocoyl methyl sodium taurocholate, and dosage is
5-10 parts of Tween 80,1-5 parts of alkyl glycosides, 1-4 parts of cocounut oil acyl methyl taurine sodium.
Preferably, the antibacterial agent is chlorhexidine acetate.
Preferably, the cosolvent is glycerol and propylene glycol, and dosage is glycerol 0.2-0.8 parts, 0.3-0.6 parts of propylene glycol.
The present invention also provides a kind of gynaecology preparation methods of antibacterial foam aerosol, comprising the following steps:
S1: Cortex Phellodendri, kuh-seng, frutus cnidii, the tuber of stemona, safflower, aloe are mixed, middle 5-7 times of addition is measured 75% ethyl alcohol and heated back
Stream extracts 1.5-3h, filtering, collects filtrate, then plus 3-5 times measure 75% ethyl alcohol, filter is collected in heating and refluxing extraction 1.5-3h, filtering
Liquid merges filtrate twice, and the dregs of a decoction are spare, and filtrate is concentrated under conditions of temperature is 70-90 DEG C, vacuum degree is -0.08MPa
Specific gravity is the medicinal extract of 1.05-1.15, obtains ethanol extract A；
S2: the dregs of a decoction are added water into decoction twice, add 7-9 times to measure water decocting time 1-3h, are filtered, filtrate, then plus 5-7 are collected
Amount water decocting time 1-3h again, filtering, by the filtrate decocted twice in the item that temperature is 70-90 DEG C, vacuum degree is -0.08MPa
Under part, it is concentrated into the medicinal extract B of specific gravity 1.05-1.15,95% ethyl alcohol is added to alcohol content in the medicinal extract B after water is extracted while stirring
It is 60%, then stands 24 hours at 5 DEG C, take supernatant, recycle ethyl alcohol and is concentrated into the medicinal extract C that specific gravity is 1.05-1.15；
S3: merging extractum A and medicinal extract C, 8-12 times of total amount purified water measured of extractum A and medicinal extract C is added while stirring, 5
It is stood at DEG C for 24 hours, filtering, filtrate is concentrated into specific gravity 1.05- under conditions of temperature is 70-90 DEG C, vacuum degree is -0.08MPa
1.15 medicinal extract D；
S4: being dissolved in 95% ethyl alcohol for borneol, chlorhexidine acetate in the reactor, and after stirring and dissolving, cowherb is added while stirring
Art oil and Rosa Damascana, glycerol and propylene glycol are then added into medicinal extract D, is added in reactor after mixing, obtains mixture；
S5: being added Tween 80, alkyl glycosides, sodium cocoyl methyl sodium taurocholate in the mixture, stirs 1h with blender,
Then it will be added in material-compound tank and stirred evenly after lactic acid, silk peptide dissolution with purified water, continued to stir 1h, obtain transparent clear antibacterial liquid,
It is canned again, propellant is added, obtains foam aerosol.
Preferably, the rate of specific gravity of the medicinal extract concentration is measured under conditions of temperature is 20 DEG C.
Preferably, the dosage of 95% ethyl alcohol is borneol, 1-3 times of acetic acid chlorine dosage in the step S4.
Preferably, propellant is F-11, difluoromethane, one in three chloro-tetrafluoroethanes in the step S5
Kind.
Raw material of the present invention is at least with the following functions:
Cortex Phellodendri: for staphylococcus aureus, staphylococcus albus, hemolytic streptococcus, Diplococcus pneumopniae, anthrax bar
Bacterium, comma bacillus, corynebacterium diphtheriae, hay bacillus, Escherichia coli, Pseudomonas aeruginosa, typhoid bacillus, paratyphosum Bacterium, meningitis are double
Coccus etc. has different degrees of inhibiting effect.
Kuh-seng: having effects that heat-clearing and damp-drying drug, desinsection, diuresis, to shigella dysenteriae, Escherichia coli, proteus, beta hemolysis
Property streptococcus and staphylococcus aureus have apparent inhibiting effect.
Frutus cnidii: warming kidney and enhancing body, eliminating dampness, wind-dispelling, desinsection.For impotence, palace cold, morbid leucorrhoea duye, arthritis with fixed pain caused by dampness pain in the loins；It controls outside outer
Vaginal eczema, married woman's pruritus vulvae；Trichomonas vaginitis.
The tuber of stemona: moistening lung to lower qi cough-relieving, desinsection.It coughs for new chronic cough, pulmonary tuberculosis cough, pertussis；Outside be used for head louse, body louse,
Enterobiasis, private parts, which is disturbed, itches.
Safflower: blood circulation, stasis eliminatings analgesic.
Aloe: having sterilization, anti-inflammatory, moistens beauty, and heart tonifying promoting blood circulation is immunized and regenerates, antitumor, removing toxic substances, anti-aging, town
Bitterly, calm, it is sun-proof the effects of.
Oil of zedoary turmeric: main to be just directed to Cutaneous infection, for candida albicans, the disease of some fungi types such as white fungi
It is especially effective, there is good effect for improving pearl bacterium property vulvovaginal disease, vaginal environment can be helped improve.
Borneol: toil is cool in nature, inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain, can be stuck up with through post, dissipates ember, has clear eyesight, relieve pain, disappear
Swollen function, also there is function of resisting myocardial ischemia, can promote Deiter's cells growth, has analgesic, anti-corrosion, anti-inflammatory effect.
The beneficial effects of the present invention are:
(1) slightly solubility substance in the Chinese medicinal component of extraction is dissolved in ethyl alcohol by preparation method provided by the present invention, then
Oil of zedoary turmeric, Rosa Damascana and surfactant is added and forms emulsion, so that diameter of aspirin particle is reached nanometer using the method for emulsification
Grade is horizontal, to improve the availability of drug.Ethyl alcohol plays the role of stabilizer in preparation process, can not only stablize oily phase, make
It is not stratified, and it is transparent it is homogeneous except, moreover it is possible to keep emulsion stable at ambient and elevated temperatures, prevent or reduce emulsion
Layering and condensate oil.Using the more comprehensive new non-ionic surfactants alkyl glycosides of performance with mild, detergency is good, blistering
Property good, foaming abundancy, exquisiteness, stabilization, it is good with skin-friendliness the features such as, arrange in pairs or groups amino acid type surfactant cocoyl first
Base sodium taurocholate, has foaming abundancy, exquisiteness, stabilization under the conditions of wide pH value, and structure containing hydrophilic amino acid pierces skin
The features such as sharp property is very small, wherein cosolvent glycerol, propylene glycol have the effect of moisturizing, lubrication again, so that product of the present invention has
The features such as excellent washing, wetting, emulsification and dispersibility, low irritant.
(2) foam aerosol of the present invention can depth administration, ejecta do not flow, and foam is stable, the duration is long, greatly
It extends drug greatly to be uniformly dispersed in the action time of lesions position, and in cavity, coating is wide, and drug can effectively penetrate into
Duplicature, curative effect are better than other dosage forms.Wherein, the foaming agent of intravaginal administration is generally acknowledged most preferred dosage form, and drug reaches disease
Can be expanded rapidly after stove, and with lesion comprehensive engagement, and adhesion is strong, plays a role convenient for vaginal mucosa absorption；In addition, bubble
The generation of foam film also mitigates chemical stimulation and physical stimulation to inflammation mucous membrane, makes vagina without sense of discomfort.
(3) Traditional Chinese medicinal aerosol prepared by the present invention, which has, sterilizes, is anti-inflammatory, antiviral, draws to bacterium, mould, fungi, trichomonad
The gynaecological imflammation risen, itch, peculiar smell etc. all have ideal effect, can be used to preventing, treating and defending for gynecological disease
Raw disinfecting.
Specific embodiment
For a better understanding of the technical solution of the present invention, below by specific embodiment to technical side of the invention
Case is described in detail.
In following embodiment, the antibacterial foam aerosol of the gynaecology includes following raw material as unit of parts by weight: yellow
3-13 parts of cypress, 4-10 parts of kuh-seng, 4-10 parts of frutus cnidii, 4-10 parts of the tuber of stemona, 1-8 parts of safflower, 1-5 parts of aloe, 1-5 parts of silk peptide, cowherb
1-5 parts of art oil, 0.1-1 parts of borneol, 0.1-1 parts of chlorhexidine acetate, 0.1-1 parts of Rosa Damascana, 5-10 parts of Tween 80, alkyl sugar
1-5 parts of glycosides, 1-4 parts of cocounut oil acyl methyl taurine sodium, 0.1-1 parts of ethyl alcohol, 0.1-1 parts of lactic acid, 0.2-0.8 parts of glycerol, propylene glycol
0.3-0.6 parts.
The preparation method of the antibacterial foam aerosol of the gynaecology, comprising the following steps:
S1: Cortex Phellodendri, kuh-seng, frutus cnidii, the tuber of stemona, safflower, aloe are mixed, middle 5-7 times of addition is measured 75% ethyl alcohol and heated back
Stream extracts 1.5-3h, filtering, collects filtrate, then plus 3-5 times measure 75% ethyl alcohol, filter is collected in heating and refluxing extraction 1.5-3h, filtering
Liquid merges filtrate twice, and the dregs of a decoction are spare, and filtrate is concentrated under conditions of temperature is 70-90 DEG C, vacuum degree is -0.08MPa
Specific gravity is the medicinal extract of 1.05-1.15, obtains ethanol extract A；
S2: the dregs of a decoction are added water into decoction twice, add 7-9 times to measure water decocting time 1-3h, are filtered, filtrate, then plus 5-7 are collected
Amount water decocting time 1-3h again, filtering, by the filtrate decocted twice in the item that temperature is 70-90 DEG C, vacuum degree is -0.08MPa
Under part, it is concentrated into the medicinal extract B of specific gravity 1.05-1.15,95% ethyl alcohol is added to alcohol content in the medicinal extract B after water is extracted while stirring
It is 60%, then stands 24 hours at 5 DEG C, take supernatant, recycle ethyl alcohol and is concentrated into the medicinal extract C that specific gravity is 1.05-1.15；
S3: merging extractum A and medicinal extract C, 8-12 times of total amount purified water measured of extractum A and medicinal extract C is added while stirring, 5
It is stood at DEG C for 24 hours, filtering, filtrate is concentrated into specific gravity 1.05- under conditions of temperature is 70-90 DEG C, vacuum degree is -0.08MPa
1.15 medicinal extract D；
S4: being dissolved in 1-3 times for borneol, chlorhexidine acetate in the reactor and measure 95% ethyl alcohol, after stirring and dissolving, while stirring
Oil of zedoary turmeric and Rosa Damascana is added, glycerol and propylene glycol are then added into medicinal extract D, is added in reactor, obtains mixed after mixing
Close object；
S5: being added Tween 80, alkyl glycosides, sodium cocoyl methyl sodium taurocholate in the mixture, stirs 1h with blender,
Then it will be added in material-compound tank and stirred evenly after lactic acid, silk peptide dissolution with purified water, continued to stir 1h, obtain transparent clear antibacterial liquid,
It is canned again, propellant is added, obtains foam aerosol.
The rate of specific gravity of medicinal extract described above is measured under conditions of 20 DEG C, and propellant is F-11, difluoro first
One of alkane, three chloro-tetrafluoroethanes.
Embodiment 1
The antibacterial foam aerosol of the gynaecology includes following raw material: 8 parts of Cortex Phellodendri, kuh-seng 8 as unit of parts by weight
Part, 10 parts of frutus cnidii, 10 parts of the tuber of stemona, 1 part of safflower, 1 part of aloe, 5 parts of silk peptide, 1 part of oil of zedoary turmeric, 0.7 part of borneol, chlorhexidine acetate
0.5 part, 1 part of Rosa Damascana, 10 parts of Tween 80,5 parts of alkyl glycosides, 4 parts of cocounut oil acyl methyl taurine sodium, 0.6 part of ethyl alcohol, cream
Sour 1 part, 0.2 part of glycerol, 0.4 part of propylene glycol.
The preparation method of the antibacterial foam aerosol of the gynaecology, comprising the following steps:
S1: Cortex Phellodendri, kuh-seng, frutus cnidii, the tuber of stemona, safflower, aloe are mixed, 7 times of 75% ethyl alcohol of amount of middle addition are heated to reflux
Extract 1.5h, filtering, collect filtrate, then plus 4 times of 75% ethyl alcohol of amount, heating and refluxing extraction 3h, filtering, collect filtrate, merging two
Secondary filtrate, the dregs of a decoction are spare, and for filtrate under conditions of temperature is 90 DEG C, vacuum degree is -0.08MPa, being concentrated into specific gravity is 1.05
Medicinal extract obtains ethanol extract A；
S2: by the dregs of a decoction add water decoction twice, add 9 times of amount water decocting time 3h, filter, collection filtrate, then plus 5-7 times measure
Water decocting time 2h, filtering, by the filtrate decocted twice under conditions of temperature is 70 DEG C, vacuum degree is -0.08MPa, concentration
To the medicinal extract B of specific gravity 1.05, it is 60% that 95% ethyl alcohol to alcohol content, which is added, in the medicinal extract B after water is extracted while stirring, then 5
24 hours are stood at DEG C, takes supernatant, recycle ethyl alcohol and is concentrated into the medicinal extract C that specific gravity is 1.10；
S3: merging extractum A and medicinal extract C, the purified water of extractum A and 12 times of medicinal extract C total amount amounts is added while stirring, at 5 DEG C
For 24 hours, filtering, filtrate is concentrated into the medicinal extract of specific gravity 1.10 to lower standing under conditions of temperature is 90 DEG C, vacuum degree is -0.08MPa
D；
S4: being dissolved in 1 times of 95% ethyl alcohol of amount for borneol, chlorhexidine acetate in the reactor, after stirring and dissolving, while stirring plus
Enter oil of zedoary turmeric and Rosa Damascana, glycerol and propylene glycol are then added into medicinal extract D, is added in reactor, must mix after mixing
Object；
S5: being added Tween 80, alkyl glycosides, sodium cocoyl methyl sodium taurocholate in the mixture, stirs 1h with blender,
Then it will be added in material-compound tank and stirred evenly after lactic acid, silk peptide dissolution with purified water, continued to stir 1h, obtain transparent clear antibacterial liquid,
It is canned again, difluoromethane is added, obtains foam aerosol.
Embodiment 2
The antibacterial foam aerosol of the gynaecology includes following raw material: 3 parts of Cortex Phellodendri, kuh-seng 4 as unit of parts by weight
Part, 6 parts of frutus cnidii, 6 parts of the tuber of stemona, 8 parts of safflower, 5 parts of aloe, 3 parts of silk peptide, 5 parts of oil of zedoary turmeric, 0.1 part of borneol, chlorhexidine acetate
0.1 part, 0.5 part of Rosa Damascana, 7 parts of Tween 80,3 parts of alkyl glycosides, 3 parts of cocounut oil acyl methyl taurine sodium, 0.1 part of ethyl alcohol, cream
Sour 0.5 part, 0.8 part of glycerol, 0.3 part of propylene glycol.
The preparation method of the antibacterial foam aerosol of the gynaecology, comprising the following steps:
S1: Cortex Phellodendri, kuh-seng, frutus cnidii, the tuber of stemona, safflower, aloe are mixed, 6 times of 75% ethyl alcohol of amount of middle addition are heated to reflux
Extract 3h, filtering, collect filtrate, then plus 3 times of 75% ethyl alcohol of amount, heating and refluxing extraction 2h, filtering, collect filtrate, merging twice
Filtrate, the dregs of a decoction are spare, and filtrate is concentrated into the leaching that specific gravity is 1.15 under conditions of temperature is 80 DEG C, vacuum degree is -0.08MPa
Cream obtains ethanol extract A；
S2: the dregs of a decoction are added water into decoction twice, add 8 times of amount water decocting time 2h, are filtered, filtrate, then plus 7 times of amount water are collected
Decocting time 1h, filtering are concentrated by the filtrate decocted twice under conditions of temperature is 90 DEG C, vacuum degree is -0.08MPa
It is 60% that 95% ethyl alcohol to alcohol content, which is added, in the medicinal extract B of specific gravity 1.15, the medicinal extract B after water is extracted while stirring, then at 5 DEG C
It is lower to stand 24 hours, supernatant is taken, ethyl alcohol is recycled and is concentrated into the medicinal extract C that specific gravity is 1.05；
S3: merging extractum A and medicinal extract C, the purified water of extractum A and 10 times of medicinal extract C total amount amounts is added while stirring, at 5 DEG C
For 24 hours, filtering, filtrate is concentrated into the medicinal extract of specific gravity 1.05 to lower standing under conditions of temperature is 80 DEG C, vacuum degree is -0.08MPa
D；
S4: being dissolved in 3 times of 95% ethyl alcohol of amount for borneol, chlorhexidine acetate in the reactor, after stirring and dissolving, while stirring plus
Enter oil of zedoary turmeric and Rosa Damascana, glycerol and propylene glycol are then added into medicinal extract D, is added in reactor, must mix after mixing
Object；
S5: being added Tween 80, alkyl glycosides, sodium cocoyl methyl sodium taurocholate in the mixture, stirs 1h with blender,
Then it will be added in material-compound tank and stirred evenly after lactic acid, silk peptide dissolution with purified water, continued to stir 1h, obtain transparent clear antibacterial liquid,
It is canned again, three chloro-tetrafluoroethanes are added, obtain foam aerosol.
Embodiment 3
The antibacterial foam aerosol of the gynaecology includes following raw material: 13 parts of Cortex Phellodendri, kuh-seng 10 as unit of parts by weight
Part, 4 parts of frutus cnidii, 4 parts of the tuber of stemona, 5 parts of safflower, 4 parts of aloe, 1 part of silk peptide, 3 parts of oil of zedoary turmeric, 1 part of borneol, 1 part of chlorhexidine acetate,
0.1 part of Rosa Damascana, 5 parts of Tween 80,1 part of alkyl glycosides, 1 part of cocounut oil acyl methyl taurine sodium, 1 part of ethyl alcohol, 0.1 part of lactic acid,
0.5 part of glycerol, 0.6 part of propylene glycol.
The preparation method of the antibacterial foam aerosol of the gynaecology, comprising the following steps:
S1: Cortex Phellodendri, kuh-seng, frutus cnidii, the tuber of stemona, safflower, aloe are mixed, 5 times of 75% ethyl alcohol of amount of middle addition are heated to reflux
Extract 2h, filtering, collect filtrate, then plus 5 times of 75% ethyl alcohol of amount, heating and refluxing extraction 1.5h, filtering, collect filtrate, merging two
Secondary filtrate, the dregs of a decoction are spare, and for filtrate under conditions of temperature is 70 DEG C, vacuum degree is -0.08MPa, being concentrated into specific gravity is 1.10
Medicinal extract obtains ethanol extract A；
S2: the dregs of a decoction are added water into decoction twice, add 7 times of amount water decocting time 1h, are filtered, filtrate, then plus 6 times of amount water are collected
Decocting time 3h, filtering are concentrated by the filtrate decocted twice under conditions of temperature is 80 DEG C, vacuum degree is -0.08MPa
It is 60% that 95% ethyl alcohol to alcohol content, which is added, in the medicinal extract B of specific gravity 1.10, the medicinal extract B after water is extracted while stirring, then at 5 DEG C
It is lower to stand 24 hours, supernatant is taken, ethyl alcohol is recycled and is concentrated into the medicinal extract C that specific gravity is 1.15；
S3: merging extractum A and medicinal extract C, the purified water of extractum A and 8 times of medicinal extract C total amount amounts is added while stirring, at 5 DEG C
Filtering for 24 hours is stood, filtrate is concentrated into the medicinal extract D of specific gravity 1.15 under conditions of temperature is 70 DEG C, vacuum degree is -0.08MPa；
S4: being dissolved in 2 times of 95% ethyl alcohol of amount for borneol, chlorhexidine acetate in the reactor, after stirring and dissolving, while stirring plus
Enter oil of zedoary turmeric and Rosa Damascana, glycerol and propylene glycol are then added into medicinal extract D, is added in reactor, must mix after mixing
Object；
S5: being added Tween 80, alkyl glycosides, sodium cocoyl methyl sodium taurocholate in the mixture, stirs 1h with blender,
Then it will be added in material-compound tank and stirred evenly after lactic acid, silk peptide dissolution with purified water, continued to stir 1h, obtain transparent clear antibacterial liquid,
It is canned again, F-11 is added, obtains foam aerosol.
Embodiment 4
The antibacterial foam aerosol of the gynaecology includes following raw material: 8 parts of Cortex Phellodendri, kuh-seng 6 as unit of parts by weight
Part, 7 parts of frutus cnidii, 5 parts of the tuber of stemona, 5 parts of safflower, 3 parts of aloe, 3 parts of silk peptide, 3 parts of oil of zedoary turmeric, 0.5 part of borneol, chlorhexidine acetate
0.6 part, 0.4 part of Rosa Damascana, 8 parts of Tween 80,3 parts of alkyl glycosides, 2 parts of cocounut oil acyl methyl taurine sodium, 95% ethyl alcohol 0.6
Part, 0.7 part of lactic acid, 0.6 part of glycerol, 0.5 part of propylene glycol.
The preparation method of the antibacterial foam aerosol of the gynaecology, comprising the following steps:
S1: Cortex Phellodendri, kuh-seng, frutus cnidii, the tuber of stemona, safflower, aloe are mixed, 6 times of 75% ethyl alcohol of amount of middle addition are heated to reflux
Extract 2h, filtering, collect filtrate, then plus 4 times of 75% ethyl alcohol of amount, heating and refluxing extraction 2h, filtering, collect filtrate, merging twice
Filtrate, the dregs of a decoction are spare, and filtrate is concentrated into the leaching that specific gravity is 1.10 under conditions of temperature is 80 DEG C, vacuum degree is -0.08MPa
Cream obtains ethanol extract A；
S2: the dregs of a decoction are added water into decoction twice, add 8 times of amount water decocting time 2h, are filtered, filtrate, then plus 6 times of amount water are collected
Decocting time 2h, filtering are concentrated by the filtrate decocted twice under conditions of temperature is 80 DEG C, vacuum degree is -0.08MPa
It is 60% that 95% ethyl alcohol to alcohol content, which is added, in the medicinal extract B of specific gravity 1.10, the medicinal extract B after water is extracted while stirring, then at 5 DEG C
It is lower to stand 24 hours, supernatant is taken, ethyl alcohol is recycled and is concentrated into the medicinal extract C that specific gravity is 1.10；
S3: merging extractum A and medicinal extract C, the purified water of extractum A and 10 times of medicinal extract C total amount amounts is added while stirring, at 5 DEG C
For 24 hours, filtering, filtrate is concentrated into the medicinal extract of specific gravity 1.10 to lower standing under conditions of temperature is 80 DEG C, vacuum degree is -0.08MPa
D；
S4: being dissolved in 2 times of 95% ethyl alcohol of amount for borneol, chlorhexidine acetate in the reactor, after stirring and dissolving, while stirring plus
Enter oil of zedoary turmeric and Rosa Damascana, glycerol and propylene glycol are then added into medicinal extract D, is added in reactor, must mix after mixing
Object；
S5: being added Tween 80, alkyl glycosides, sodium cocoyl methyl sodium taurocholate in the mixture, stirs 1h with blender,
Then it will be added in material-compound tank and stirred evenly after lactic acid, silk peptide dissolution with purified water, continued to stir 1h, obtain transparent clear antibacterial liquid,
It is canned again, F-11 is added, obtains foam aerosol.
Comparative example 1
Preparation method is same as Example 4, the difference is that not adding alkyl glycosides, sodium cocoyl methyl ox in raw material
Sodium sulfonate.
Comparative example 2
Preparation method is same as Example 4, the difference is that not adding oil of zedoary turmeric, Rosa Damascana in raw material.
Comparative example 3
According to Chinese patent document, " a kind of, shield yin antibacterial for human vagina, the drug and preparation method thereof of clean yin are (special
Benefit number: 201010541982.7) 1 the method for embodiment prepares vagina antibacterial medicines in ".
1. fungistatic effect is tested
The method described in embodiment 1-4 and comparative example 1-3 prepares antibacterial medicines, carries out fungistatic effect pair to each group drug
Than test, as a result as shown in the table below:
2. the efficacy experiment of rat vagina inflammation
The foundation of rat vagina inflammation model: staphylococcus aureus (3 × 10 will be injected in rat vagina-3A/m1) and it is big
Enterobacteria (16 × 10-3A/m1) 0.05ml/100g, the next day, inoculates primary, takes vaginal fluid to do Bacteria Culture and painting after 5d
Successful 60 rats of modeling are randomly divided into 5 groups by piece microscopy: chemicals embodiment 1-4 of the present invention, blank control group.Yin
Road carries out spray foam aerosol, 1 time a day, continuous 7 days.Vaginal fluid is taken to do bacterium training respectively within the 1st, 2,5 day after drug withdrawal
It supports and smear for microscopic examination, 3 equal negative patients of inspection pathogen is to turn out cloudy.It is set to 100% (degree of inflammation), medicine with the score value of matrix group
Object group can obtain the degree of inflammation of medicine group, matrix group and the difference of medicine group degree of inflammation are drug compared with matrix group
Group healing degree.Efficacy result is as follows.
3. human body gynecopathy therapeutic is tested
In development process of the present invention, for show drug of the present invention to the therapeutic effect and safety of gynaecologic vaginal disease,
Inventor studies after the pharmaceutical preparation of many years and clinic trial practical studies repeatedly, while also selecting to common gynaecology's yin
Antibacterial, the sterilization test that the virus of road infection, bacterium are implemented, above-mentioned research and experiment can prove that drug of the present invention has
The effect of the treatment gynaecologic vaginal disease of broad spectrum activity.
Selection 68 suffer from the patient of gynecological disease, carry out quality testing using drug prepared by the embodiment of the present invention 4, often
It after 7 days, counts treatment condition using once.
Therapeutic effect judgment criteria:
Cure: it is normally standard that gynecological patient items, which are examined,；
It is effective: the impression without exception of gynecological patient vagina；
It is invalid: various symptoms without, hence it is evident that improve.
Through counting, 78 patients have 30 to be cured, vagina impression without exception after 47 patient's treatments, 1 people gynaecology disease
Disease is not improved, it is seen that the present invention is to the treated effect of gynecological disease up to 98.7%.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to utilize this hair
Equivalent transformation made by bright specification is applied directly or indirectly in other relevant technical fields, is similarly included in this hair
In bright scope of patent protection.
Claims (9)
1. a kind of antibacterial foam aerosol of gynaecology, which is characterized in that include following raw material: Cortex Phellodendri 3-13 as unit of parts by weight
Part, 4-10 parts of kuh-seng, 4-10 parts of frutus cnidii, 4-10 parts of the tuber of stemona, 1-8 parts of safflower, 1-5 parts of aloe, 1-5 parts of silk peptide, oil of zedoary turmeric 1-5
Part, 0.1-1 parts of borneol, 0.1-1 parts of antibacterial agent, 0.1-1 parts of Rosa Damascana, 7-20 parts of surfactant, 0.1-1 parts of ethyl alcohol, cream
It is 0.1-1 parts sour, 0.6-1.4 parts of cosolvent.
2. the antibacterial foam aerosol of gynaecology according to claim 1, which is characterized in that as unit of parts by weight include with
Lower raw material: 8 parts of Cortex Phellodendri, 6 parts of kuh-seng, 7 parts of frutus cnidii, 5 parts of the tuber of stemona, 5 parts of safflower, 3 parts of aloe, 3 parts of silk peptide, 3 parts of oil of zedoary turmeric, ice
0.5 part of piece, 0.6 part of antibacterial agent, 0.4 part of Rosa Damascana, 15 parts of surfactant, 0.6 part of ethyl alcohol, 0.7 part of lactic acid, cosolvent 1
Part.
3. the antibacterial foam aerosol of gynaecology according to claim 1, which is characterized in that the surfactant is to spit
Warm 80, alkyl glycosides, sodium cocoyl methyl sodium taurocholate, dosage are Tween 80 5-10 parts, 1-5 parts of alkyl glycosides, cocounut oil acyl first
1-4 parts of base sodium taurocholate.
4. the antibacterial foam aerosol of gynaecology according to claim 1, which is characterized in that the antibacterial agent be acetic acid chlorine oneself
It is fixed.
5. the antibacterial foam aerosol of gynaecology according to claim 1, which is characterized in that the cosolvent is glycerol and third
Glycol, dosage are glycerol 0.2-0.8 parts, 0.3-0.6 parts of propylene glycol.
6. a kind of preparation method of the antibacterial foam aerosol of gynaecology according to claim 1, which is characterized in that including with
Lower step:
S1: Cortex Phellodendri, kuh-seng, frutus cnidii, the tuber of stemona, safflower, aloe are mixed, and middle 5-7 times of addition, which is measured 75% ethyl alcohol and is heated to reflux, to be mentioned
Take 1.5-3h, filter, collect filtrate, then plus 3-5 times measure 75% ethyl alcohol, filtrate is collected in heating and refluxing extraction 1.5-3h, filtering,
Merge filtrate twice, the dregs of a decoction are spare, and filtrate is concentrated into specific gravity under conditions of temperature is 70-90 DEG C, vacuum degree is -0.08MPa
For the medicinal extract of 1.05-1.15, ethanol extract A is obtained；
S2: by the dregs of a decoction add water decoction twice, add 7-9 times to measure water decocting time 1-3h, filter, collect filtrate, then plus 5-7 times measure
Water decocting time 1-3h, filtering, by the filtrate decocted twice under conditions of temperature is 70-90 DEG C, vacuum degree is -0.08MPa,
It is concentrated into the medicinal extract B of specific gravity 1.05-1.15,95% ethyl alcohol to alcohol content is added while stirring and is by the medicinal extract B after water is extracted
60%, 24 hours then are stood at 5 DEG C, takes supernatant, ethyl alcohol is recycled and is concentrated into the medicinal extract C that specific gravity is 1.05-1.15；
S3: merging extractum A and medicinal extract C, 8-12 times of total amount purified water measured of extractum A and medicinal extract C is added while stirring, at 5 DEG C
Filtering for 24 hours is stood, filtrate is concentrated into specific gravity 1.05-1.15 under conditions of temperature is 70-90 DEG C, vacuum degree is -0.08MPa
Medicinal extract D；
S4: being dissolved in 95% ethyl alcohol for borneol, chlorhexidine acetate in the reactor, and after stirring and dissolving, oil of zedoary turmeric is added while stirring
And Rosa Damascana, glycerol and propylene glycol are then added into medicinal extract D, is added in reactor after mixing, obtains mixture；
S5: being added Tween 80, alkyl glycosides, sodium cocoyl methyl sodium taurocholate in the mixture, stirs 1h with blender, then
It will be added in material-compound tank and stirred evenly after lactic acid, silk peptide dissolution with purified water, continued to stir 1h, obtain transparent clear antibacterial liquid, then tank
Dress is added propellant, obtains foam aerosol.
7. the gynaecology according to claim 6 preparation method of antibacterial foam aerosol, which is characterized in that the medicinal extract is dense
The rate of specific gravity of contracting is measured under conditions of temperature is 20 DEG C.
8. the gynaecology according to claim 6 preparation method of antibacterial foam aerosol, which is characterized in that the step S4
In the dosage of 95% ethyl alcohol be borneol, 1-3 times of acetic acid chlorine dosage.
9. the gynaecology according to claim 6 preparation method of antibacterial foam aerosol, which is characterized in that the step S5
Middle propellant is one of F-11, difluoromethane, three chloro-tetrafluoroethanes.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110464811A (en) * | 2019-09-18 | 2019-11-19 | 西安新君力生物科技有限公司 | A kind of gynaecology's foam antibacterial liquid and preparation method thereof |
| CN111165478A (en) * | 2020-02-11 | 2020-05-19 | 南通大学 | Foam type sterilization, disinfection and air purification agent and preparation method and application thereof |
| CN112891487A (en) * | 2021-02-07 | 2021-06-04 | 厦门辰海生物科技有限公司 | Bacteriostatic liquid capable of tightening vagina and preventing HPV and preparation method thereof |
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| CN102160887A (en) * | 2010-11-19 | 2011-08-24 | 厦门金日制药有限公司 | Medicament for treating gynecological inflammation and preparation method thereof |
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| CN102160887A (en) * | 2010-11-19 | 2011-08-24 | 厦门金日制药有限公司 | Medicament for treating gynecological inflammation and preparation method thereof |
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| CN110464811A (en) * | 2019-09-18 | 2019-11-19 | 西安新君力生物科技有限公司 | A kind of gynaecology's foam antibacterial liquid and preparation method thereof |
| CN111165478A (en) * | 2020-02-11 | 2020-05-19 | 南通大学 | Foam type sterilization, disinfection and air purification agent and preparation method and application thereof |
| CN112891487A (en) * | 2021-02-07 | 2021-06-04 | 厦门辰海生物科技有限公司 | Bacteriostatic liquid capable of tightening vagina and preventing HPV and preparation method thereof |
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Effective date of registration: 20190403 Address after: 410000 North Building, 15th Floor 15007, Baili Building, 208 Section of Xiaoxiang South Road, Yanghu Street, Yuelu District, Changsha City, Hunan Province Applicant after: Hunan Hugongfu Biotechnology Co., Ltd. Address before: 410000 Aishan Angel, 26th Floor, Coral Hotel 368 South Furong Road Section, Tianxin District, Changsha City, Hunan Province Applicant before: Zhang Huan |
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