CN109010600A - The luxuriant and rich with fragrance sub- wine of enamel - Google Patents
The luxuriant and rich with fragrance sub- wine of enamel Download PDFInfo
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- CN109010600A CN109010600A CN201811005483.9A CN201811005483A CN109010600A CN 109010600 A CN109010600 A CN 109010600A CN 201811005483 A CN201811005483 A CN 201811005483A CN 109010600 A CN109010600 A CN 109010600A
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- 239000003205 fragrance Substances 0.000 title claims abstract description 45
- 241000241627 Pfaffia Species 0.000 claims abstract description 48
- 239000004615 ingredient Substances 0.000 claims abstract description 26
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 23
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- 210000003056 antler Anatomy 0.000 claims abstract description 23
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G3/00—Preparation of other alcoholic beverages
- C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The present invention relates to the luxuriant and rich with fragrance sub- wine of enamel, belong to herbal wine field.The luxuriant and rich with fragrance sub- wine of enamel includes accounting for gross mass 2-3% pfaffia, 4-6% rhizoma polygonati, 4-6% fructus lycii, 2-3% ginseng, 1-2% pilose antler, 4-6% Chinese yam, 2-3% Semen Cuscutae, 71-75% base liquor respectively.The granularity of pfaffia is allocated by the present invention in proportion, be conducive to the progress of rear continuous preparation, the space of instrument can be made full use of, and the granularity of the Chinese herbal medicine in addition to pfaffia is controlled smaller, this can be conducive to coming into full contact with for medicinal material and solvent so that varigrained Chinese herbal medicine is upper even closer in arrangement.It is simple and easy to get through techniques such as ingredient, swelling, exhaust, dipping, diacolations, it is easy to accomplish industrialization.
Description
Technical field
The present invention relates to the luxuriant and rich with fragrance sub- wine of enamel, belong to herbal wine field.
Background technique
Enamel is luxuriant and rich with fragrance sub-, also known as pfaffia, is a kind of rare rare medicinal herbs, is mainly distributed on the Brazilian tropical rain forest of South America
Area.The magical effect that pfaffia has nourishing as the wild ginseng of China, cordyceps sinensis, keeps fit and healthy, promotes longevity
Fruit.It can also adjust the physiological function integral level of each system of human body comprehensively, therefore to various people for having chronic disease symptom, each
People, the physical fatigue weakling of item physiological dysfunction, effect is the most significant, can be used as medicine, enter wine.
The main chemical compositions of wine are ethyl alcohol, typically contain micro fusel and Ester, the concentration one of edible distillate spirit
As 60 degree (i.e. 60%) below (minority has 60 degree or more).Just so-called integration of drinking and medicinal herbs, wine as common beverage, itself
It is a kind of Chinese medicine, sweet in flavor, bitter, pungent, warm-natured, fragrant odour, can rise can dissipate, and declare row medicine thing, there is promoting blood circulation and removing obstruction in channels, expelling wind and clearing away cold,
The effect of smelly deodorization is rectified, is just allowing for the pharmacological property of wine itself, while the ethyl alcohol of higher concentration is conducive to other Chinese herbal medicines again
Effective component is precipitated, and liquid medicine comes into being.Liquid medicine divides Orally taken and externally, the common traumatic injury of external application person, and person for oral administration is often directed to a certain
Illness, and by the advantage of the two be combined as a whole to drink liquid medicine uncommon.
Summary of the invention
In view of the above problems, the present invention provides one kind using pfaffia as main ingredient, in expelling wind and activating blood flow, the pain-relieving powder for treating stasis of blood
On the basis of, there is the luxuriant and rich with fragrance sub- wine of enamel of nourishing, conditioning.
To achieve the goals above, the invention adopts the following technical scheme:
The luxuriant and rich with fragrance sub- wine of enamel, the luxuriant and rich with fragrance sub- wine of the enamel includes accounting for gross mass 2-3% pfaffia, 4-6% rhizoma polygonati, 4-6% Chinese holly respectively
Matrimony vine, 2-3% ginseng, 1-2% pilose antler, 4-6% Chinese yam, 2-3% Semen Cuscutae, 71-75% base liquor.
Sick deep lesion with the passing of time often leads to the loss of human body gas, blood, yin, yang, and treatment restores to be difficult to accomplish in one move,
It is typically necessary a process.Chinese medicine thinks that human body has channels and collaterals, and channels and collaterals general rule all kinds of diseases and ailments are non-sticky, master one and you'll master a hundred.Various chronic void
Disease is damaged, is usually present that different degrees of qi and blood is unsmooth, passages through which vital energy circulates is not smooth, treatment needs assistant with drug promoting blood circulation and removing obstruction in channels to increase often
Strong curative effect.And the luxuriant and rich with fragrance sub- main compatibility of wine of enamel has the tonic Chinese herbal medicine of blood-enrich, nourishing yin and warming yang, is beneficial to treat chronic disease,
And it builds up resistance.
In the ingredient of the luxuriant and rich with fragrance sub- wine of enamel, using the luxuriant and rich with fragrance Asia of enamel as main ingredient, chemical component mainly includes triterpene and triterpenoid saponin
Class, steroid and its saponins compound, have anti-aging, antifatigue, establishing-Yang and antitumor special efficacy, and its through wine processing at
Active constituent dissolution is fast after reason, is conducive to produce；Rhizoma polygonati is sweet in flavor, mild-natured, has anti-oxidant, anti-aging, adjusts immunity, improves
Memory function and prevent senile dementia, antidepression, hypoglycemic, Adjust-blood lipid and antiatherosclerosis, anti-inflammatory, antitumor, disease-resistant
The wide applications such as poison, heart tonifying, antibacterial, and the polysaccharide of rhizoma polygonati, saponin content are higher, can preferably mix with the luxuriant and rich with fragrance Asia of enamel；Fructus lycii
Sweet natured, fructus lycii contains polysaccharides, amino acid, vitamin, has the effect of that hypoglycemic, antitumor, enhancing is immune；People
Join mild-natured tepor, active constituent includes saponin(e, volatile oil, polysaccharide, polypeptide etc., has and adjusts blood pressure, protects central nervous system
The effects of system, liver protecting, anti-aging；Pilose antler is leached through alcohol containing 18 kinds of amino acid including 8 kinds of amino acid needed by human
And cephalin, lecithin, the lipid sphyngomyelin of the important substance of human body brain cell are constituted, also containing the various trace elements such as calcium, zinc, energy
Promote the metabolism of brain cell, adjusts function of human body；Chinese yam is sweet in flavor mild-natured, living rich in the biology such as polysaccharide, saponin, allantoin
Property ingredient, have anti-oxidant, anti-aging, anti-mutation, inhibiting cancer, immunological regulation and other effects；Semen Cuscutae nature and flavor are pungent, sweet, flat, containing Huang
The chemical components such as ketone, polysaccharide, alkaloids have kidney-supplementing liver-boosting, astringent sperm contracting urine, miscarriage prevention, improving eyesight, antidiarrheal and other effects.Though
Chinese medicine in the right luxuriant and rich with fragrance Asia wine of enamel is common medicinal material, still, for main ingredient, there is no research, the work of the luxuriant and rich with fragrance Asia of enamel itself with the luxuriant and rich with fragrance Asia of enamel
Property ingredient can be combined well with the active constituent of other Chinese herbal medicines, be not in the pharmacological property runed counter to, and be adjustable each Chinese herbal medicine
Between conjugation, be conducive to promote further enhancing for each active constituent.
Preferably, being additionally added the arillus longan for accounting for gross mass 1-4% in the luxuriant and rich with fragrance sub- wine ingredient of enamel, arillus longan, which is cut, is ground into granularity
For 10-60 mesh powder.Arillus longan is sweet in flavor, mild-natured, nontoxic, is rich in carbohydrate, lipid, saponins, polypeptide, Polyphenols, volatilization
Property ingredient, amino acid and microelement, not only there are anti-ageing equal medicinal efficacies, while can be used for adjusting the flavor of vina.
Preferably, it is 24-80 mesh powder that pfaffia, which is ground into granularity,.
Further preferably, in pfaffia powder, granularity is that 65-80 mesh powder accounts for pfaffia content of powder
10-20%, surplus are granularity 24-64 mesh powder.
Preferably, it is 10-60 purpose that rhizoma polygonati, fructus lycii, ginseng, pilose antler, Chinese yam, Semen Cuscutae, which are individually ground into granularity,
Powder.
Further preferably, in the powder, granularity is that 10-24 mesh powder accounts for 6-12%, and surplus is granularity 25-60 mesh
Powder.
Liquid medicine is exactly the combination of medicine and wine, and how to combine the two well, and middle the effective elements of the medicine is precipitated and preparation
Method, Chinese herbal medicine granularity are closely related.The granularity of pfaffia is allocated by the present invention in proportion, is conducive to subsequent preparation side
The progress of method, can make full use of the space of instrument, and by the control of the granularity of the Chinese herbal medicine in addition to pfaffia smaller, this can
So that varigrained Chinese herbal medicine is upper even closer in arrangement, be conducive to coming into full contact with for medicinal material and solvent.And at this stage
Liquid medicine preparation, the material that same particle sizes are made in medicinal material is often prepared, cannot not only make full use of vessel space, can also make
It is insufficient at being precipitated.
The present invention additionally provides another technical solution while reasonable selection material mixture ratio:
The preparation method of the luxuriant and rich with fragrance sub- wine of enamel, includes the following steps:
(1) ingredient: weighing raw material by above-mentioned ingredient, by pfaffia, rhizoma polygonati, fructus lycii, ginseng, pilose antler, Chinese yam, Tu
Silk is ground into powder；
(2) it is swollen: powder is placed in closed container, pour into the base liquor of one times of powder amount, impregnate 2-4h；
(3) it is vented: being laid with one layer of cotton in percolator, by the powder filling percolator after swelling, cover one layer of filter
Paper, then pour into enough base liquors and be sufficiently vented；
(4) it impregnates: the percolator after exhaust is sealed into 20-28h；
(5) diacolation: a separatory funnel is fixed above percolator, and base liquor is added in separatory funnel, then controls infiltration
It filters the flow velocity of cylinder and separatory funnel, collects percolate.
The present invention carries out the preparation of liquid medicine using percolation, can carry out under normal temperature environment, guarantees the activity in medicinal material
Substance is not destroyed because of temperature change.
Preferably, big particle size powders are replaced with small grain size powder and are filled out when step (3) powder inserts percolator
Enter, when powder height is percolator 1/3, pushed with T-bar, and rotate clockwise 20-30 degree, continues to insert powder, work as powder
When last height is percolator 2/3, pushed with T-bar, and rotate clockwise 15-25 degree.At this stage for loading medicine in percolator
Material is often directly pushed with T-bar, this will lead to, and medicinal material gap is excessive, and exhaust is insufficient, causes exudation incomplete.And
The present invention just solves by changing T-bar pushing and slightly rotating angle and loads incomplete hidden danger.
Preferably, the flow velocity of percolator described in step (5) is 2-4ml/min, the flow velocity of the separatory funnel is 2-
4ml/min.The flow velocity of separatory funnel and percolator is all to need to be set according to Medicinal Materials Characters, too fast to be all unfavorable for medicine slowly excessively
The exudation of material effective component.
Compared with prior art, the present invention has the advantage that
(1) based on the pharmacology of monarch, based on pfaffia, cooperation rhizoma polygonati, fructus lycii, ginseng, pilose antler, Chinese yam,
Supplemented by Semen Cuscutae, arillus longan, so that the luxuriant and rich with fragrance sub- wine of enamel has effects that expelling wind and activating blood flow, the pain-relieving powder for treating stasis of blood, and body can be substantially improved
Resistance.
(2) by changing the particle size range and proportion of medicinal material, percolation can be improved to greatest extent to having in medicinal material
Limit the extraction of ingredient.
(3) according to Traditional Chinese medical theory, the function that prevention and treatment combines is reached by " channels and collaterals general rule all kinds of diseases and ailments are non-sticky, master one and you'll master a hundred "
Energy.
Specific embodiment
The following is specific embodiments of the present invention, and technical scheme of the present invention will be further described, but the present invention is simultaneously
It is not limited to these embodiments.
Embodiment 1
Ingredient: weighing raw material by above-mentioned ingredient, including accounts for 2.5% pfaffia of gross mass, 5% rhizoma polygonati, 5% fructus lycii
Son, 2.5% ginseng, 1.5% pilose antler, 5% Chinese yam, 2.5% Semen Cuscutae, 73% base liquor, 3% arillus longan, pfaffia is crushed
It is 50 mesh and 70 mesh powders at granularity, wherein granularity is that 70 mesh powders account for the 15% of pfaffia content of powder, and surplus is
50 mesh powder of granularity；It is 20 mesh that rhizoma polygonati, fructus lycii, ginseng, pilose antler, Chinese yam, Semen Cuscutae, arillus longan, which are respectively crushed into granularity,
With 40 mesh powders, wherein granularity is that 20 mesh powders account for 9%, and surplus is 40 mesh powder of granularity.
Swelling: powder is placed in closed container, pours into the base liquor of one times of powder amount, impregnates 3h.
Exhaust: it is laid with one layer of cotton in percolator, the big particle size powders after swelling are replaced into filling with small grain size powder
It in percolator, when powder height is percolator 1/3, is pushed with T-bar, and rotate clockwise 25 degree, continues to insert powder, when
When powder height is percolator 2/3, is pushed with T-bar, and rotate clockwise 20 degree, cover one layer of filter paper after completing powder, then
Enough base liquors are poured into sufficiently to be vented.
Dipping: for 24 hours by the percolator sealing after exhaust.
Diacolation: a separatory funnel is fixed above percolator, and base liquor is added in separatory funnel, then control percolator
Flow velocity be 3ml/min, the flow velocity of separatory funnel is 3ml/min, collects percolate.
Embodiment 2
Ingredient: weighing raw material by above-mentioned ingredient, including account for 2% pfaffia of gross mass, 5% rhizoma polygonati, 6% fructus lycii,
2% ginseng, 2% pilose antler, 5% Chinese yam, 2% Semen Cuscutae, 75% base liquor, 1% arillus longan, it is 24 that pfaffia, which is ground into granularity,
Mesh and 80 mesh powders, wherein granularity is that 80 mesh powders account for the 10% of pfaffia content of powder, and surplus is 24 purpose of granularity
Powder；Rhizoma polygonati, fructus lycii, ginseng, pilose antler, Chinese yam, Semen Cuscutae, arillus longan are respectively crushed into the powder that granularity is 10 mesh and 60 mesh
End, wherein granularity is that 10 mesh powders account for 6%, and surplus is 60 mesh powder of granularity.
Swelling: powder is placed in closed container, pours into the base liquor of one times of powder amount, impregnates 3h.
Exhaust: it is laid with one layer of cotton in percolator, the big particle size powders after swelling are replaced into filling with small grain size powder
It in percolator, when powder height is percolator 1/3, is pushed with T-bar, and rotate clockwise 25 degree, continues to insert powder, when
When powder height is percolator 2/3, is pushed with T-bar, and rotate clockwise 20 degree, cover one layer of filter paper after completing powder, then
Enough base liquors are poured into sufficiently to be vented.
Dipping: for 24 hours by the percolator sealing after exhaust.
Diacolation: a separatory funnel is fixed above percolator, and base liquor is added in separatory funnel, then control percolator
Flow velocity be 3ml/min, the flow velocity of separatory funnel is 3ml/min, collects percolate.
Embodiment 3
Ingredient: weighing raw material by above-mentioned ingredient, including account for 3% pfaffia of gross mass, 4% rhizoma polygonati, 6% fructus lycii,
3% ginseng, 2% pilose antler, 6% Chinese yam, 3% Semen Cuscutae, 71% base liquor, 2% arillus longan, it is 35 that pfaffia, which is ground into granularity,
Mesh and 70 mesh powders, wherein granularity is that 70 mesh powders account for the 20% of pfaffia content of powder, and surplus is 35 purpose of granularity
Powder；Rhizoma polygonati, fructus lycii, ginseng, pilose antler, Chinese yam, Semen Cuscutae, arillus longan are respectively crushed into the powder that granularity is 15 mesh and 50 mesh
End, wherein granularity is that 15 mesh powders account for 12%, and surplus is 50 mesh powder of granularity.
Swelling: powder is placed in closed container, pours into the base liquor of one times of powder amount, impregnates 3h.
Exhaust: it is laid with one layer of cotton in percolator, the big particle size powders after swelling are replaced into filling with small grain size powder
It in percolator, when powder height is percolator 1/3, is pushed with T-bar, and rotate clockwise 25 degree, continues to insert powder, when
When powder height is percolator 2/3, is pushed with T-bar, and rotate clockwise 20 degree, cover one layer of filter paper after completing powder, then
Enough base liquors are poured into sufficiently to be vented.
Dipping: for 24 hours by the percolator sealing after exhaust.
Diacolation: a separatory funnel is fixed above percolator, and base liquor is added in separatory funnel, then control percolator
Flow velocity be 3ml/min, the flow velocity of separatory funnel is 3ml/min, collects percolate.
Embodiment 4
Ingredient: weighing raw material by above-mentioned ingredient, including accounts for 2.5% pfaffia of gross mass, 5% rhizoma polygonati, 5% fructus lycii
Son, 2.5% ginseng, 1.5% pilose antler, 5% Chinese yam, 2.5% Semen Cuscutae, 73% base liquor, 3% arillus longan, pfaffia is crushed
It is 50 mesh and 70 mesh powders at granularity, wherein granularity is that 70 mesh powders account for the 15% of pfaffia content of powder, and surplus is
50 mesh powder of granularity；It is 20 mesh that rhizoma polygonati, fructus lycii, ginseng, pilose antler, Chinese yam, Semen Cuscutae, arillus longan, which are respectively crushed into granularity,
With 40 mesh powders, wherein granularity is that 20 mesh powders account for 9%, and surplus is 40 mesh powder of granularity.
Swelling: powder is placed in closed container, pours into the base liquor of one times of powder amount, impregnates 2h.
Exhaust: it is laid with one layer of cotton in percolator, the big particle size powders after swelling are replaced into filling with small grain size powder
It in percolator, when powder height is percolator 1/3, is pushed with T-bar, and rotate clockwise 20 degree, continues to insert powder, when
When powder height is percolator 2/3, is pushed with T-bar, and rotate clockwise 15 degree, cover one layer of filter paper after completing powder, then
Enough base liquors are poured into sufficiently to be vented.
Dipping: for 24 hours by the percolator sealing after exhaust.
Diacolation: a separatory funnel is fixed above percolator, and base liquor is added in separatory funnel, then control percolator
Flow velocity be 3ml/min, the flow velocity of separatory funnel is 3ml/min, collects percolate.
Embodiment 5
Ingredient: weighing raw material by above-mentioned ingredient, including accounts for 2.5% pfaffia of gross mass, 5% rhizoma polygonati, 5% fructus lycii
Son, 2.5% ginseng, 1.5% pilose antler, 5% Chinese yam, 2.5% Semen Cuscutae, 73% base liquor, 3% arillus longan, pfaffia is crushed
It is 50 mesh and 70 mesh powders at granularity, wherein granularity is that 70 mesh powders account for the 15% of pfaffia content of powder, and surplus is
50 mesh powder of granularity；It is 20 mesh that rhizoma polygonati, fructus lycii, ginseng, pilose antler, Chinese yam, Semen Cuscutae, arillus longan, which are respectively crushed into granularity,
With 40 mesh powders, wherein granularity is that 20 mesh powders account for 9%, and surplus is 40 mesh powder of granularity.
Swelling: powder is placed in closed container, pours into the base liquor of one times of powder amount, impregnates 4h.
Exhaust: it is laid with one layer of cotton in percolator, the big particle size powders after swelling are replaced into filling with small grain size powder
It in percolator, when powder height is percolator 1/3, is pushed with T-bar, and rotate clockwise 30 degree, continues to insert powder, when
When powder height is percolator 2/3, is pushed with T-bar, and rotate clockwise 25 degree, cover one layer of filter paper after completing powder, then
Enough base liquors are poured into sufficiently to be vented.
Dipping: for 24 hours by the percolator sealing after exhaust.
Diacolation: a separatory funnel is fixed above percolator, and base liquor is added in separatory funnel, then control percolator
Flow velocity be 3ml/min, the flow velocity of separatory funnel is 3ml/min, collects percolate.
Embodiment 6
Ingredient: weighing raw material by above-mentioned ingredient, including accounts for 2.5% pfaffia of gross mass, 5% rhizoma polygonati, 5% fructus lycii
Son, 2.5% ginseng, 1.5% pilose antler, 5% Chinese yam, 2.5% Semen Cuscutae, 73% base liquor, 3% arillus longan, pfaffia is crushed
It is 50 mesh and 70 mesh powders at granularity, wherein granularity is that 70 mesh powders account for the 15% of pfaffia content of powder, and surplus is
50 mesh powder of granularity；It is 20 mesh that rhizoma polygonati, fructus lycii, ginseng, pilose antler, Chinese yam, Semen Cuscutae, arillus longan, which are respectively crushed into granularity,
With 40 mesh powders, wherein granularity is that 20 mesh powders account for 9%, and surplus is 40 mesh powder of granularity.
Swelling: powder is placed in closed container, pours into the base liquor of one times of powder amount, impregnates 3h.
Exhaust: it is laid with one layer of cotton in percolator, the big particle size powders after swelling are replaced into filling with small grain size powder
It in percolator, when powder height is percolator 1/3, is pushed with T-bar, and rotate clockwise 25 degree, continues to insert powder, when
When powder height is percolator 2/3, is pushed with T-bar, and rotate clockwise 20 degree, cover one layer of filter paper after completing powder, then
Enough base liquors are poured into sufficiently to be vented.
Dipping: the percolator after exhaust is sealed into 20h.
Diacolation: a separatory funnel is fixed above percolator, and base liquor is added in separatory funnel, then control percolator
Flow velocity be 2ml/min, the flow velocity of separatory funnel is 2ml/min, collects percolate.
Embodiment 7
Ingredient: weighing raw material by above-mentioned ingredient, including accounts for 2.5% pfaffia of gross mass, 5% rhizoma polygonati, 5% fructus lycii
Son, 2.5% ginseng, 1.5% pilose antler, 5% Chinese yam, 2.5% Semen Cuscutae, 73% base liquor, 3% arillus longan, pfaffia is crushed
It is 50 mesh and 70 mesh powders at granularity, wherein granularity is that 70 mesh powders account for the 15% of pfaffia content of powder, and surplus is
50 mesh powder of granularity；It is 20 mesh that rhizoma polygonati, fructus lycii, ginseng, pilose antler, Chinese yam, Semen Cuscutae, arillus longan, which are respectively crushed into granularity,
With 40 mesh powders, wherein granularity is that 20 mesh powders account for 9%, and surplus is 40 mesh powder of granularity.
Swelling: powder is placed in closed container, pours into the base liquor of one times of powder amount, impregnates 3h.
Exhaust: it is laid with one layer of cotton in percolator, the big particle size powders after swelling are replaced into filling with small grain size powder
It in percolator, when powder height is percolator 1/3, is pushed with T-bar, and rotate clockwise 25 degree, continues to insert powder, when
When powder height is percolator 2/3, is pushed with T-bar, and rotate clockwise 20 degree, cover one layer of filter paper after completing powder, then
Enough base liquors are poured into sufficiently to be vented.
Dipping: the percolator after exhaust is sealed into 28h.
Diacolation: a separatory funnel is fixed above percolator, and base liquor is added in separatory funnel, then control percolator
Flow velocity be 4ml/min, the flow velocity of separatory funnel is 4ml/min, collects percolate.
Embodiment 8
Difference with embodiment 1 is only that, contains only pfaffia 3%, base liquor 97% in the luxuriant and rich with fragrance sub- wine of 8 enamel of embodiment.
Embodiment 9
Difference with embodiment 1 is only that pfaffia content is 1% in the luxuriant and rich with fragrance sub- wine of 9 enamel of embodiment.
Embodiment 10
Difference with embodiment 1 is only that pfaffia content is 4% in the luxuriant and rich with fragrance sub- wine of 10 enamel of embodiment.
Embodiment 11
Difference with embodiment 1 is only that the granularity of 11 pfaffia of embodiment is 85 mesh.
Embodiment 12
Difference with embodiment 1 is only that the granularity of 12 pfaffia of embodiment is 20 mesh.
Embodiment 13
Difference with embodiment 1 is only that the granularity of raw material of the embodiment 13 in addition to pfaffia is 5 mesh.
Embodiment 14
Difference with embodiment 1 is only that the granularity of raw material of the embodiment 14 in addition to pfaffia is 70 mesh.
Embodiment 15
Difference with embodiment 1 is only that, in 15 bleeding of embodiment, T-bar only carries out primary clockwise when filler
Rotation.
Comparative example 1
Difference with embodiment 1 is only that, is free of arillus longan in the luxuriant and rich with fragrance sub- wine of 1 enamel of comparative example.
Comparative example 2
Difference with embodiment 1 is only that the raw material of the luxuriant and rich with fragrance sub- wine of 2 enamel of comparative example is without powder processed.
Comparative example 3
Difference with embodiment 1 is only that, is rotated when filler without T-bar in 3 steps of exhausting of comparative example.
Embodiment 1-15 and the luxuriant and rich with fragrance sub- wine of enamel made of comparative example 1-3 are detected, its color, flavor, stability are detected,
It is specific as shown in table 1:
Table 1: the performance of embodiment 1-15, comparative example 1-3 product
The small white mouse that experiment uses is male, and environmental parameter is 23 ± 2 DEG C of temperature, and humidity 45 ± 15%, 12:12h is bright
Dark alternately small white mouse independently feeds, and is randomly divided into 4 groups, every group 10 after adapting to 7 days.
Experimental group 1
Mice lavage is administered in the luxuriant and rich with fragrance sub- wine of the enamel that embodiment 1 is obtained, and dosage is 0.2ml/10g weight, is continuously given
Medicine 14 days.
Blank control group 1
Difference with experimental group 1 is only that blank control group 1 changes the luxuriant and rich with fragrance sub- wine of enamel into clear water.
Blank control group 2
Difference with experimental group 1 is only that blank control group 2 changes the luxuriant and rich with fragrance sub- wine of enamel into base liquor.
Positive controls 1
Difference with experimental group 1 is only that positive controls 1 change the luxuriant and rich with fragrance sub- wine of enamel into diazepam solution, and dosage is
15mg/Kg weight.(Beijing Yimin Pharmaceutical Co., Ltd., lot number H11020898,2.5mg/ piece, is ground with dismembyator, adds physiology
The solution of 0.75mg/ml is made in salt water, ready-to-use).
1, after above-mentioned 4 groups of last dose 1h, yellow Jackets (44mg/Kg), volume injected is injected intraperitoneally in each group
Mouse web portion is placed in mouse cage (37 DEG C) by 0.1ml/10g upward, and the sleeping time for recording mouse, (righting reflex loss was held
The continuous time) and Sleep latency (anyway incubation period of areflexia).Wherein, it the judgment criteria of righting reflex: is turned in for the first time
Back position is placed again immediately after just, if not turning over i.e. righting reflex loss in 20s automatically, instead.The results are shown in Table 2.
2, after above-mentioned 4 groups of last dose 1h, yellow Jackets (29mg/Kg), volume injected is injected intraperitoneally in each group
0.1ml/10g, with righting reflex loss 1min, the above are sleep standards, record each group sleep mouse in 30min, and sleep occurs
The results are shown in Table 2 for rate.
Table 2: experimental group and control group mice state follow-up result
Time data in table 2 are average.It is obviously high to the mice sleep incidence and sleeping time of the luxuriant and rich with fragrance sub- wine of enamel
In the only mouse of stomach-filling clear water or base liquor, without there is potent sedation effect as downern, it was demonstrated that enamel luxuriant and rich with fragrance sub- wine
Good sleeping characteristic.
Experimental group 2
Give normal 50-70 years old volunteer (being normal constitution) evening bfore meals the luxuriant and rich with fragrance sub- wine of enamel that embodiment 1 obtains, clothes
Dosage is 50ml, and daily work and rest is normal.
Experimental group 3
Difference with experimental group 2 is only that 3 Time of Administration of experimental group is before sleeping.
Control group 3
Difference with experimental group 2 is only that the luxuriant and rich with fragrance sub- wine of enamel is replaced with clear water by control group 3.
Control group 4
Difference with control group 3 is only that 4 Time of Administration of control group is before sleeping.
The subsequent volunteer to experimental group and control group carries out state follow-up, and the results are shown in Table 3:
Table 2: experimental group 2-3 and control group 3-4 volunteer state follow-up result
Flu in table 3 is not only the literal meaning, and statistics number includes volunteer's fever, deep coughs, headache, sternly
The numbers such as density current tears, abscess of throat, it is upper as can be seen that the luxuriant and rich with fragrance sub- wine of enamel of the invention is suffered from the case where continuing long-term taking from person-time
Flu person-time is decreased obviously, and the luxuriant and rich with fragrance sub- wine of enamel can be obviously improved the body immune ability of volunteer, from internal microcosmic upper explanation, and
Oxidation factor is reduced.And the Time of Administration of the luxuriant and rich with fragrance sub- wine of enamel, large effect will not be caused to effect.
To sum up, the present invention is special uses pfaffia for main ingredient, and supplemented by a variety of common herbal medicine, it is thick and heavy to configure color, mouth
Taste is limpid pleasant, is not only convenient for quoting, and more a variety of unmentionalbe diseases can be eliminated in continuously drinking, when promoting sleep quality and sleep
Between, and then promote the resistance and oxidation resistance of body.
It is skilled to this field although present invention has been described in detail and some specific embodiments have been cited
For technical staff, as long as it is obvious for can making various changes or correct without departing from the spirit and scope of the present invention.
Claims (9)
1. the luxuriant and rich with fragrance sub- wine of enamel, which is characterized in that the luxuriant and rich with fragrance sub- wine of the enamel is yellow including accounting for gross mass 2-3% pfaffia, 4-6% respectively
Essence, 4-6% fructus lycii, 2-3% ginseng, 1-2% pilose antler, 4-6% Chinese yam, 2-3% Semen Cuscutae, 71-75% base liquor.
2. the luxuriant and rich with fragrance sub- wine of enamel according to claim 1, which is characterized in that be additionally added in the luxuriant and rich with fragrance sub- wine ingredient of the enamel and account for gross mass
The arillus longan of 1-4%, it is 10-60 mesh powder that arillus longan, which is cut and is ground into granularity,.
3. the luxuriant and rich with fragrance sub- wine of enamel according to claim 1, which is characterized in that it is 24-80 mesh that the pfaffia, which is ground into granularity,
Powder.
4. the luxuriant and rich with fragrance sub- wine of enamel according to claim 3, which is characterized in that in the pfaffia powder, granularity is 65-80 mesh
Powder account for the 10-20% of pfaffia content of powder, surplus is granularity 24-64 mesh powder.
5. the luxuriant and rich with fragrance sub- wine of enamel according to claim 1, which is characterized in that the rhizoma polygonati, fructus lycii, ginseng, pilose antler, Chinese yam,
It is 10-60 mesh powder that Semen Cuscutae, which is individually ground into granularity,.
6. the luxuriant and rich with fragrance sub- wine of enamel according to claim 5, which is characterized in that in the powder, granularity is that 10-24 mesh powder accounts for
6-12%, surplus are granularity 25-60 mesh powder.
7. the preparation method of the luxuriant and rich with fragrance sub- wine of enamel, which is characterized in that the preparation method includes the following steps:
(1) ingredient: ingredient according to claim 1 weighs raw material, by pfaffia, rhizoma polygonati, fructus lycii, ginseng, pilose antler, mountain
Medicine, Semen Cuscutae are ground into powder；
(2) it is swollen: powder is placed in closed container, pour into the base liquor of one times of powder amount, impregnate 2-4h；
(3) it is vented: being laid with one layer of cotton in percolator, by the powder filling percolator after swelling, cover one layer of filter paper, then
Enough base liquors are poured into sufficiently to be vented；
(4) it impregnates: the percolator after exhaust is sealed into 20-28h；
(5) diacolation: a separatory funnel is fixed above percolator, and base liquor is added in separatory funnel, then control percolator
With the flow velocity of separatory funnel, percolate is collected.
8. preparation method according to claim 7, which is characterized in that, will be big when step (3) powder inserts percolator
Particle size powders replace filling with small grain size powder, when powder height is percolator 1/3, are pushed with T-bar, and rotate clockwise
20-30 degree continues to insert powder, when powder height is percolator 2/3, is pushed with T-bar, and rotate clockwise 15-25 degree.
9. preparation method according to claim 7, which is characterized in that the flow velocity of percolator described in step (5) is 2-
4ml/min, the flow velocity of the separatory funnel are 2-4ml/min.
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| CN110499230A (en) * | 2019-09-25 | 2019-11-26 | 游鹏 | A kind of emerald wine production vessel and its application method |
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