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CN108926766A - A kind of micro stimulator and micro stimulator system - Google Patents

A kind of micro stimulator and micro stimulator system Download PDF

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Publication number
CN108926766A
CN108926766A CN201810887322.0A CN201810887322A CN108926766A CN 108926766 A CN108926766 A CN 108926766A CN 201810887322 A CN201810887322 A CN 201810887322A CN 108926766 A CN108926766 A CN 108926766A
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stimulator
micro
lower limbs
movement
paralyzed
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沈晓燕
许�鹏
马磊
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Nantong University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551Spinal or peripheral nerve electrodes
    • A61N1/0558Anchoring or fixation means therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36062Spinal stimulation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36067Movement disorders, e.g. tremor or Parkinson disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128Control systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • A61N1/37205Microstimulators, e.g. implantable through a cannula
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • A61N1/37211Means for communicating with stimulators
    • A61N1/37217Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Rehabilitation Tools (AREA)

Abstract

本发明涉及生物学领域,尤其涉及一种微刺激器及微刺激器系统。所述重建瘫痪下肢运动的微刺激器以ARM Cortex处理器为核心,以WIFI形式接收无线终端的运动指令,ARM Cortex处理器经过分析指令信息并产生相应刺激信号,再经信号驱动电路输出至电极端激活CPG脊髓神经网络,使患者产生不同的下肢运动步态。所述微刺激器及微刺激器系统能有效重建瘫痪的下肢运动功能,给因为脊髓损伤导致下肢体运动功能障碍的患者提供了治愈的新方法,不仅减轻了患者的身心伤害,并大大减轻了家庭及整个社会的经济负担。本发明对探索神经系统的信息处理机制、促进生命、信息等学科的交叉融合的研究都具有重要意义。

The invention relates to the field of biology, in particular to a micro stimulator and a micro stimulator system. The micro stimulator for reconstructing paralyzed lower limb movement takes the ARM Cortex processor as the core, and receives the movement instructions of the wireless terminal in the form of WIFI. Extreme activation of the CPG spinal cord neural network causes patients to produce different lower limb motor gaits. The micro-stimulator and the micro-stimulator system can effectively reconstruct the motor function of the paralyzed lower limbs, and provide a new cure method for patients with lower limb motor dysfunction caused by spinal cord injury, which not only reduces the physical and mental injuries of the patients, but also greatly reduces the economic burden on the family and society as a whole. The invention is of great significance for exploring the information processing mechanism of the nervous system and promoting the research of interdisciplinary integration of life, information and other disciplines.

Description

一种微刺激器及微刺激器系统A kind of micro stimulator and micro stimulator system

技术领域technical field

本发明涉及生物学领域,尤其涉及一种微刺激器及微刺激器系统。The invention relates to the field of biology, in particular to a micro stimulator and a micro stimulator system.

背景技术Background technique

脊髓损伤导致损伤节段以下肢体运动功能障碍,不仅会给患者本人带来身心伤害,还会对家庭及整个社会造成巨大的经济负担。因此,重建瘫痪下肢运动功能一直是神经科学研究中的一项重要课题。Spinal cord injury leads to motor dysfunction of the limbs below the injured segment, which will not only bring physical and mental harm to the patient, but also cause a huge economic burden to the family and the whole society. Therefore, reconstructing the motor function of paralyzed lower limbs has always been an important topic in neuroscience research.

研究瘫痪下肢运动功能调控机理的目的是为了更有效实现瘫痪下肢运动功能的重建。在研究了基于脊髓内固有的CPG环路控制下肢步行运动的激励信号和明确诱发CPG活动关键位点的基础上,急需研发一种控制平台以实现控制和调节下肢协调运动。The purpose of studying the regulation mechanism of motor function of paralyzed lower limbs is to realize the reconstruction of motor function of paralyzed lower limbs more effectively. Based on the study of the excitation signals that control the walking movement of the lower limbs based on the inherent CPG loop in the spinal cord and the identification of key sites that induce CPG activity, it is urgent to develop a control platform to control and regulate the coordinated movement of the lower limbs.

发明内容Contents of the invention

本发明所解决的技术问题在于提供一种微刺激器及微刺激器系统,该微刺激器能有效重建瘫痪的下肢运动功能,给因为脊髓损伤导致下肢体运动功能障碍的患者提供了治愈的新方法,不仅减轻了患者的身心伤害,并大大减轻了家庭及整个社会的经济负担。The technical problem to be solved by the present invention is to provide a micro stimulator and micro stimulator system, the micro stimulator can effectively reconstruct the motor function of paralyzed lower limbs, and provide a new cure for patients with lower limb motor dysfunction caused by spinal cord injury. This method not only reduces the physical and mental harm of patients, but also greatly reduces the economic burden on the family and the whole society.

本发明所解决的技术问题采用以下技术方案来实现:The technical problem solved by the present invention adopts following technical scheme to realize:

本发明一方面提供了一种用于重建瘫痪下肢运动的微刺激器,所述微刺激器以ARM Cortex处理器为核心,以WIFI形式接收无线终端的运动指令,ARMCortex处理器经过分析指令信息并产生相应刺激信号,再经信号驱动电路输出至电极端激活CPG脊髓神经网络,使患者产生不同的下肢运动步态。One aspect of the present invention provides a micro-stimulator for reconstructing the movement of paralyzed lower limbs. The micro-stimulator uses an ARM Cortex processor as the core to receive motion instructions from wireless terminals in the form of WIFI. The ARM Cortex processor analyzes the instruction information and The corresponding stimulation signal is generated, and then output to the electrode terminal through the signal driving circuit to activate the CPG spinal cord neural network, so that the patient can produce different lower limb movement gaits.

优选的,所述微刺激器的运行状态分为功能关系构建状态和运动功能训练状态。Preferably, the operating state of the micro stimulator is divided into a functional relationship building state and a motor function training state.

优选的,所述微刺激器为可植入的微刺激器。Preferably, the micro stimulator is an implantable micro stimulator.

优选的,所述微刺激器包括一个或者多个固定元件。Preferably, the micro stimulator includes one or more fixation elements.

更优选的,所述一个或者多个固定元件包括一个或者多个钩子、倒钩或者锚固器。More preferably, said one or more fixation elements comprise one or more hooks, barbs or anchors.

本发明第二个方面提供了一种微刺激器系统,该系统包括上述的微刺激器,还包括遥控终端和笔记本电脑;所述微刺激器通过WIFI与所述遥控终端、所述笔记本电脑一一连接;The second aspect of the present invention provides a kind of micro-stimulator system, and this system comprises above-mentioned micro-stimulator, also comprises remote control terminal and notebook computer; a connection;

通过所述笔记本电脑中的刺激器功能重建软件进行操作,将构建的映射表发送至所述微刺激器中存储,使用所述遥控终端向所述微刺激器发送运动指令并产生刺激信号,所述刺激信号直接驱动测试对象的下肢运动,以训练和提升下肢的运动机能。Operate through the stimulator function reconstruction software in the notebook computer, send the constructed mapping table to the micro stimulator for storage, use the remote control terminal to send motion instructions to the micro stimulator and generate stimulation signals, so The above stimulation signals directly drive the lower limbs of the test subject to train and improve the motor function of the lower limbs.

优选的,所述遥控终端的硬件包括MCU核、WIFI模块、按键输入模块及显示模块。Preferably, the hardware of the remote control terminal includes an MCU core, a WIFI module, a key input module and a display module.

优选的,将构建的映射表发送至微刺激器中的Flash存储。Preferably, the constructed mapping table is sent to the Flash storage in the micro stimulator.

本发明第三个方面提供了上述的微刺激器系统在瘫痪病人的肢体运动功能重建中的应用。The third aspect of the present invention provides the application of the above-mentioned micro-stimulator system in the reconstruction of limb motor function of paralyzed patients.

与现有技术相比,本发明至少具有如下优点或者有益效果:Compared with the prior art, the present invention has at least the following advantages or beneficial effects:

本发明提供了一种微刺激器及微刺激器系统,该微刺激器能有效重建瘫痪的下肢运动功能,给因为脊髓损伤导致下肢体运动功能障碍的患者提供了治愈的新方法,不仅减轻了患者的身心伤害,并大大减轻了家庭及整个社会的经济负担。本发明对探索神经系统的信息处理机制、促进生命、信息等学科的交叉融合的研究都具有重要意义。The invention provides a micro-stimulator and a micro-stimulator system, the micro-stimulator can effectively reconstruct the motor function of the paralyzed lower limbs, and provides a new cure method for patients with motor dysfunction of the lower limbs caused by spinal cord injury, which not only relieves the The physical and mental harm of patients, and greatly reduce the economic burden of the family and the whole society. The invention is of great significance for exploring the information processing mechanism of the nervous system and promoting the research of interdisciplinary integration of life, information and other disciplines.

附图说明Description of drawings

利用附图对本发明作进一步说明,但附图中的实施例不构成对本发明的任何限制。The present invention will be further described by using the accompanying drawings, but the embodiments in the accompanying drawings do not constitute any limitation to the present invention.

图1为本发明实施例中微刺激器系统的工作示意图。Fig. 1 is a working diagram of the micro stimulator system in the embodiment of the present invention.

具体实施方式Detailed ways

下面结合具体实施例,进一步阐述本发明。应理解,这些实施例仅用于本发明而不用于限制本发明的范围。Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only for the present invention and are not intended to limit the scope of the present invention.

实施例1Example 1

本实施例公开了一种用于重建瘫痪下肢运动的微刺激器,所述微刺激器以ARMCortex处理器为核心,以WIFI形式接收无线终端的运动指令,ARM Cortex处理器经过分析指令信息并产生相应刺激信号,再经信号驱动电路输出至电极端激活CPG脊髓神经网络,使患者产生不同的下肢运动步态。This embodiment discloses a micro-stimulator for reconstructing the movement of paralyzed lower limbs. The micro-stimulator uses the ARM Cortex processor as the core to receive motion commands from wireless terminals in the form of WIFI. The ARM Cortex processor analyzes the command information and generates Corresponding stimulation signals are then output to the electrode terminals through the signal drive circuit to activate the CPG spinal cord neural network, so that patients can produce different lower limb movement gaits.

所述微刺激器的运行状态分为功能关系构建状态和运动功能训练状态。微刺激器有功能关系构建和运动功能训练两种运行状态。功能关系构建状态用于针对某个测试对象构建运动步态与刺激信号的关系映射表,通过笔记本电脑中的刺激器功能重建软件操作,并能够将构建后的映射表发送至ARM处理器的Flash中存储。运动功能训练状态用于下肢运动障碍者做康复训练,测试对象使用遥控式终端向微刺激器发送运动指令产生刺激信号,直接驱动测试对象下肢运动,以训练和提升下肢的运动机能。The operating state of the micro stimulator is divided into a functional relationship building state and a motor function training state. The microstimulator has two operating states: functional relationship building and motor function training. The functional relationship construction state is used to construct the relationship mapping table between motion gait and stimulus signal for a certain test object, operate through the stimulator function reconstruction software in the notebook computer, and can send the constructed mapping table to the Flash of the ARM processor stored in. The motor function training state is used for rehabilitation training for people with lower limb movement disabilities. The test subject uses the remote control terminal to send motion instructions to the micro stimulator to generate stimulation signals, which directly drives the test subject to move the lower limbs to train and improve the motor function of the lower limbs.

所述微刺激器为可植入的微刺激器。The microstimulator is an implantable microstimulator.

所述微刺激器包括一个或者多个固定元件。The microstimulator includes one or more fixation elements.

所述一个或者多个固定元件包括一个或者多个钩子、倒钩或者锚固器。The one or more fixation elements include one or more hooks, barbs or anchors.

实施例2Example 2

本实施例公开了一种微刺激器系统,包括实施例1所述的微刺激器,还包括遥控终端和笔记本电脑;所述微刺激器通过WIFI与所述遥控终端、所述笔记本电脑一一连接;This embodiment discloses a micro stimulator system, including the micro stimulator described in Embodiment 1, and also includes a remote control terminal and a notebook computer; the micro stimulator communicates with the remote control terminal and the notebook computer through WIFI connect;

通过所述笔记本电脑中的刺激器功能重建软件进行操作,将构建的映射表发送至所述微刺激器中存储,使用所述遥控终端向所述微刺激器发送运动指令并产生刺激信号,所述刺激信号直接驱动测试对象的下肢运动,以训练和提升下肢的运动机能。Operate through the stimulator function reconstruction software in the notebook computer, send the constructed mapping table to the micro stimulator for storage, use the remote control terminal to send motion instructions to the micro stimulator and generate stimulation signals, so The above stimulation signals directly drive the lower limbs of the test subject to train and improve the motor function of the lower limbs.

所述遥控终端的硬件包括MCU核、WIFI模块、按键输入模块及显示模块。The hardware of the remote control terminal includes an MCU core, a WIFI module, a key input module and a display module.

将构建的映射表发送至微刺激器中的Flash存储。Send the constructed map to the flash memory in the microstimulator.

以上对本发明的具体实施例进行了详细描述,但其只是作为范例,本发明并不限制于以上描述的具体实施例。对于本领域技术人员而言,任何对本发明进行的等同修改和替代也都在本发明的范畴之中。因此,在不脱离本发明的精神和范围下所作的均等变换和修改,都应涵盖在本发明的范围内。The specific embodiments of the present invention have been described in detail above, but they are only examples, and the present invention is not limited to the specific embodiments described above. For those skilled in the art, any equivalent modifications and substitutions to the present invention are also within the scope of the present invention. Therefore, equivalent changes and modifications made without departing from the spirit and scope of the present invention shall fall within the scope of the present invention.

Claims (9)

1.一种用于重建瘫痪下肢运动的微刺激器,其特征在于,所述微刺激器以ARM Cortex处理器为核心,以WIFI形式接收无线终端的运动指令,ARM Cortex处理器经过分析指令信息并产生相应刺激信号,再经信号驱动电路输出至电极端激活CPG脊髓神经网络,使患者产生不同的下肢运动步态。1. A micro-stimulator for reconstructing the movement of paralyzed lower limbs, characterized in that, the micro-stimulator takes the ARM Cortex processor as the core, receives the motion instruction of the wireless terminal in the form of WIFI, and the ARM Cortex processor analyzes the instruction information And generate corresponding stimulation signals, and then output to the electrode terminals through the signal driving circuit to activate the CPG spinal cord neural network, so that patients can produce different lower limb movement gaits. 2.根据权利要求1所述的重建瘫痪下肢运动的微刺激器,其特征在于,所述微刺激器的运行状态分为功能关系构建状态和运动功能训练状态。2. The micro-stimulator for reconstructing the movement of paralyzed lower limbs according to claim 1, wherein the operating state of the micro-stimulator is divided into a functional relationship building state and a motor function training state. 3.根据权利要求1所述的重建瘫痪下肢运动的微刺激器,其特征在于,所述微刺激器为可植入的微刺激器。3. The micro-stimulator for reconstructing the movement of paralyzed lower limbs according to claim 1, wherein the micro-stimulator is an implantable micro-stimulator. 4.根据权利要求1所述的重建瘫痪下肢运动的微刺激器,其特征在于,所述微刺激器包括一个或者多个固定元件。4. The micro stimulator for reconstructing the movement of paralyzed lower limbs according to claim 1, characterized in that the micro stimulator comprises one or more fixation elements. 5.根据权利要求4所述的重建瘫痪下肢运动的微刺激器,其特征在于,所述一个或者多个固定元件包括一个或者多个钩子、倒钩或者锚固器。5. The micro-stimulator for reconstructing the movement of paralyzed lower limbs according to claim 4, wherein the one or more fixation elements comprise one or more hooks, barbs or anchors. 6.一种微刺激器系统,其特征在于,包括权利要求1-5任意一项所述的微刺激器,还包括遥控终端和笔记本电脑;所述微刺激器通过WIFI与所述遥控终端、所述笔记本电脑一一连接;6. A micro stimulator system, characterized in that it comprises the micro stimulator described in any one of claims 1-5, and also includes a remote control terminal and a notebook computer; the micro stimulator communicates with the remote control terminal, The notebook computers are connected one by one; 通过所述笔记本电脑中的刺激器功能重建软件进行操作,将构建的映射表发送至所述微刺激器中存储,使用所述遥控终端向所述微刺激器发送运动指令并产生刺激信号,所述刺激信号直接驱动测试对象的下肢运动,以训练和提升下肢的运动机能。Operate through the stimulator function reconstruction software in the notebook computer, send the constructed mapping table to the micro stimulator for storage, use the remote control terminal to send motion instructions to the micro stimulator and generate stimulation signals, so The above stimulation signals directly drive the lower limbs of the test subject to train and improve the motor function of the lower limbs. 7.根据权利要求6所述的微刺激器系统,其特征在于,所述遥控终端的硬件包括MCU核、WIFI模块、按键输入模块及显示模块。7. The micro-stimulator system according to claim 6, wherein the hardware of the remote control terminal comprises an MCU core, a WIFI module, a key input module and a display module. 8.根据权利要求6所述的微刺激器系统,其特征在于,将构建的映射表发送至微刺激器中的Flash存储。8. The micro-stimulator system according to claim 6, wherein the mapping table constructed is sent to the Flash storage in the micro-stimulator. 9.根据权利要求6-8中任意一项所述的微刺激器系统在瘫痪病人的肢体运动功能重建中的应用。9. The application of the micro-stimulator system according to any one of claims 6-8 in the reconstruction of limb motor function of paralyzed patients.
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