CN108785374A - Faint scent cassia bark skin bacteriostatic gel and preparation method thereof - Google Patents
Faint scent cassia bark skin bacteriostatic gel and preparation method thereof Download PDFInfo
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- CN108785374A CN108785374A CN201810972087.7A CN201810972087A CN108785374A CN 108785374 A CN108785374 A CN 108785374A CN 201810972087 A CN201810972087 A CN 201810972087A CN 108785374 A CN108785374 A CN 108785374A
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- faint scent
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- cassia bark
- water
- bacteriostatic gel
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- 235000014489 Cinnamomum aromaticum Nutrition 0.000 title claims abstract description 99
- 230000003385 bacteriostatic effect Effects 0.000 title claims abstract description 72
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 238000001879 gelation Methods 0.000 title description 3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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Abstract
The invention discloses faint scent cassia bark skin bacteriostatic gels and preparation method thereof.The faint scent cassia bark skin bacteriostatic gel, including following raw materials：Menthol, herba elsholtziae essential oil, great Ye faint scent osmanthus concentrate, Tween 80, glycerine, Acritamer 940, water.Faint scent cassia bark skin bacteriostatic gel of the present invention uses multitude's medicine composition, use the pure plant essence of natural herb, antibiotic-free is added without hormone, it has no toxic side effect, will not develop immunity to drugs, can adjust and improve human body micro-ecological environment, it is formed with the environment of sharp beneficial flora, the ecological environment for destroying pernicious bacteria reaches and improves self immunity of skin and self-repairing capability, thoroughly effects a radical cure dermatopathy.
Description
Technical field
The present invention relates to pharmaceutical techniques fields, more particularly to faint scent cassia bark skin bacteriostatic gel and preparation method thereof.
Background technology
The skin and mucous membrane of human body surface covering are the defence lines that human body resists external pathogenic microorganisms invasion, when wound occurs
It is easy to be infected, dressing for skin bactericidal effect common at present is not obvious, or has significant irritation, and use is uncomfortable.
Therefore, in order to solve the problems such as skin is by the itch, redness, pain occurred after bacterium or fungal infection, in the market for
The demand of effective good bacteriostatic gel is huge.
The invention of application number 201610917525.0 is related to a kind of hyaluronic acid bacteriostatic gel, and parts by weight of raw materials group becomes：
50-60 parts of hyaluronic acid, 30-4 parts of Chinese medical extract, DCBA15-20 parts, 3-5 parts of ethyl alcohol, 5-8 parts of glycerine, purified water 10-
15 parts；The traditional Chinese medicine extraction raw material is radix ampelopsis, the root of Dahurain angelica, PORIA ALBA, pueraria lobata, root of Chinese trichosanthes, Rhizoma Atractylodis Macrocephalae, dandelion, Fructus Forsythiae, gold and silver
Flower, radix paeoniae rubra, the root bark of tree peony, kuh-seng, Radix Glycyrrhizae.There is bacteriostasis to staphylococcus aureus, Escherichia coli, pseudomonas aeruginosa, apply
It smears in skin, forms skin sparing film, be suitable for that skin is antibacterial and antibacterial protection and the daily skin care of postoperative skin wound.
The present invention provides a kind of faint scent cassia bark skin bacteriostatic gel, using multitude's medicine composition, uses the pure plant essence of natural herb
China, antibiotic-free are added without hormone, are had no toxic side effect, and one of main active constituent is great Ye faint scent osmanthus concentrate.
Faint scent osmanthus (Sarcococca ruscifolia Stapf) is Buxaceae Sarcococca plant, is born in height above sea level 600m
Hillside sparse woods in limes marginis.The ground such as Hainan Province, Yunnan Province are distributed in, have the function of cooling blood and removing stasis, removing toxic substances sore, it is civil main
For treating stomach trouble, bruise internal lesion caused by overexertion, dizzy palpitaition, throat swelling and pain etc..
Invention content
The first object of the present invention is to provide a kind of faint scent cassia bark skin bacteriostatic gel.
To realize the above-mentioned technical purpose, the technical solution adopted by the present invention is：
The present invention discloses a kind of faint scent cassia bark skin bacteriostatic gel, including following raw materials：Menthol, herba elsholtziae essential oil, great Ye
Faint scent osmanthus concentrate, Tween 80, glycerine, Acritamer 940, water.
Specifically, faint scent cassia bark skin bacteriostatic gel of the present invention, includes the raw material of following weight ratio：Menthol 0.1~
0.3wt%, herba elsholtziae essential oil 0.5~2wt%, great Ye faint scent osmanthus 1~5wt% of concentrate, 4~6wt% of Tween 80, glycerine 5~
10wt%, 0.5~1.5wt% of Acritamer 940, surplus are water.
The weight ratio of the herba elsholtziae essential oil is preferably 0.5wt%.
The weight ratio of great Ye faint scent osmanthus concentrate is preferably 1wt%.
The weight ratio of the Acritamer 940 is preferably 1wt%.
Further, the faint scent cassia bark skin bacteriostatic gel is prepared by the raw material of following weight ratio：Menthol 0.1~
0.3wt%, herba elsholtziae essential oil 0.5~2wt%, great Ye faint scent osmanthus 1~5wt% of concentrate, 4~6wt% of Tween 80, glycerine 5~
10wt%, 0.01~0.1wt% of preservative, acetic acid 0.1~0.3wt% of chlorhexidine, skin penetrant azone 0.01~
0.05wt%, 0.5~1.5wt% of Acritamer 940, surplus are water.
Wherein, the weight ratio of the menthol is preferably 0.1wt%, and the weight ratio of the Tween 80 is preferably 4wt%, institute
The weight ratio for stating glycerine is preferably 5wt%.
The second object of the present invention is to provide a kind of preparation method of faint scent cassia bark skin bacteriostatic gel, including following step
Suddenly：
S1 weighs following raw materials according to formula：0.1~0.3wt% of menthol, herba elsholtziae essential oil 0.5~2wt%, great Ye are clear
Fragrant osmanthus 1~5wt% of concentrate, 4~6wt% of Tween 80,5~10wt% of glycerine, 0.01~0.1wt% of preservative, acetic acid chlorine is
Fixed 0.1~0.3wt%, skin penetrant 0.01~0.05wt% of azone, 0.5~1.5wt% of Acritamer 940, surplus is water；
S2 prepares water phase：By great Ye faint scent osmanthus concentrate, preservative, acetic acid chlorhexidine, skin penetrant azone, carbomer
940, water is uniformly mixed, and obtains water phase；
S3 prepares oil phase：Menthol, herba elsholtziae essential oil, Tween 80, glycerine are uniformly mixed, oil phase is obtained；
Oil phase is added in water phase by S4, is uniformly mixed, is obtained faint scent cassia bark skin bacteriostatic gel.
Faint scent cassia bark skin bacteriostatic gel of the present invention uses multitude's medicine composition, uses the pure plant essence of natural herb, nothing
Antibiotic is added without hormone, is had no toxic side effect, will not be developed immunity to drugs, can adjust and improve human body micro-ecological environment, shape
At the environment of advantageous beneficial flora, the ecological environment of pernicious bacteria is destroyed, is reached and is improved self immunity of skin and self repair
Reactivation power, thoroughly effects a radical cure dermatopathy.
Specific implementation mode
Raw material is described below in embodiment：
Menthol, No. CAS：89-78-1.
Great Ye faint scent osmanthus, source area Hainan.
Tween 80, No. CAS：9005-65-6.
Glycerine, No. CAS：56-81-5.
Sodium benzoate, No. CAS：532-32-1.
Acetic acid chlorhexidine, No. CAS：56-95-1.
Skin penetrant azone, No. CAS：59227-89-3.
Acritamer 940, No. CAS：9007-20-9.
Attapulgite, Lingshou County Sheng Fei mineral products processings factory provide.
Without illustrating, the concrete technology condition of vacuum freeze drying is：- 80 DEG C of pre-freezing temperature, pre-freeze
Time 2 h, -70 DEG C of cryogenic temperature, absolute pressure 100Pa, sublimation drying 48 hours.
Embodiment 1
Faint scent cassia bark skin bacteriostatic gel, is prepared by the raw material of following weight ratio：Menthol 0.1wt%, herba elsholtziae essence
Oily 0.5wt%, great Ye faint scent osmanthus concentrate 1%wt, Tween 80 4wt%, glycerine 5wt%, sodium benzoate 0.03%, acetic acid chlorine
Determine 0.1%, skin penetrant azone 0.03%, Acritamer 940 1wt%, surplus is water.
The preparation method of faint scent cassia bark skin bacteriostatic gel includes the following steps：
S1 weighs following raw materials according to formula：Menthol 0.1wt%, the concentration of herba elsholtziae essential oil 0.5wt%, great Ye faint scent osmanthus
Liquid 1%wt, Tween 80 4wt%, glycerine 5wt%, sodium benzoate 0.03%, acetic acid chlorhexidine 0.1%, skin penetrant azone
0.03%, Acritamer 940 1wt%, surplus is water；
S2 prepares water phase：By great Ye faint scent osmanthus concentrate, sodium benzoate, acetic acid chlorhexidine, skin penetrant azone, card wave
Nurse 940, water are uniformly mixed, and obtain water phase；
S3 prepares oil phase：Menthol, herba elsholtziae essential oil, Tween 80, glycerine are uniformly mixed, oil phase is obtained；
Oil phase is added in water phase by S4, is uniformly mixed, is obtained the faint scent cassia bark skin bacteriostatic gel.
Herba elsholtziae essential oil is commercially available.
Great Ye faint scent osmanthus concentrate obtains by the following method：Great Ye faint scent cassia lignea flours is broken, 60 mesh sieve is crossed, is obtained big
Leaf faint scent cassia lignea flour end；The ethanol water of volume fraction 80% is added into great Ye faint scent cassia lignea flours end, ethanol water weight is
15 times of great Ye faint scent cassia lignea flour end, refluxing extraction is concentrated under reduced pressure after 2 hours under conditions of 65 DEG C, absolute pressure 0.03MPa
To the great Ye faint scent osmanthus concentrate of relative density 1.08.
Embodiment 2
Faint scent cassia bark skin bacteriostatic gel, is prepared by the raw material of following weight ratio：Menthol 0.1wt%, herba elsholtziae essence
Oily 0.5wt%, great Ye faint scent osmanthus concentrate 1%wt, Tween 80 4wt%, glycerine 5wt%, sodium benzoate 0.03%, acetic acid chlorine
Determine 0.1%, skin penetrant azone 0.03%, Acritamer 940 1wt%, surplus is water.
The preparation method of faint scent cassia bark skin bacteriostatic gel includes the following steps：
S1 weighs following raw materials according to formula：Menthol 0.1wt%, the concentration of herba elsholtziae essential oil 0.5wt%, great Ye faint scent osmanthus
Liquid 1%wt, Tween 80 4wt%, glycerine 5wt%, sodium benzoate 0.03%, acetic acid chlorhexidine 0.1%, skin penetrant azone
0.03%, Acritamer 940 1wt%, surplus is water；
S2 prepares water phase：By great Ye faint scent osmanthus concentrate, sodium benzoate, acetic acid chlorhexidine, skin penetrant azone, card wave
Nurse 940, water are uniformly mixed, and obtain water phase；
S3 prepares oil phase：Menthol, herba elsholtziae essential oil, Tween 80, glycerine are uniformly mixed, oil phase is obtained；
Oil phase is added in water phase by S4, is uniformly mixed, is obtained the faint scent cassia bark skin bacteriostatic gel.
Great Ye faint scent osmanthus concentrate obtains by the following method：Great Ye faint scent cassia lignea flours is broken, 60 mesh sieve is crossed, is obtained big
Leaf faint scent cassia lignea flour end；The ethanol water of volume fraction 80% is added into great Ye faint scent cassia lignea flours end, ethanol water weight is
15 times of great Ye faint scent cassia lignea flour end, refluxing extraction is concentrated under reduced pressure after 2 hours under conditions of 65 DEG C, absolute pressure 0.03MPa
To the great Ye faint scent osmanthus concentrate of relative density 1.08.
The herba elsholtziae essential oil is obtained by steam distillation method：Fresh herba elsholtziae is taken, 20 mesh sieve is crushed, obtains
Herba elsholtziae powder；It weighs herba elsholtziae powder to be put into steam distillation device, water is added and so that solid-liquid ratio is 1：50 (g/mL) steam
After evaporating 180 minutes, milky emulsion is collected；The salt of its weight 7% is added into milky emulsion, is uniformly mixed
Afterwards, 20h separation is stood, upper oil phase is collected；Anhydrous sodium sulfate drying is added into upper oil phase, is used after placing 20 hours
300 mesh filter-cloth filterings, obtain herba elsholtziae essential oil.
Embodiment 3
Faint scent cassia bark skin bacteriostatic gel, is prepared by the raw material of following weight ratio：Menthol 0.1wt%, herba elsholtziae essence
Oily 0.5wt%, great Ye faint scent osmanthus concentrate 1%wt, Tween 80 4wt%, glycerine 5wt%, sodium benzoate 0.03%, acetic acid chlorine
Determine 0.1%, skin penetrant azone 0.03%, Acritamer 940 1wt%, surplus is water.
The preparation method of faint scent cassia bark skin bacteriostatic gel includes the following steps：
S1 weighs following raw materials according to formula：Menthol 0.1wt%, the concentration of herba elsholtziae essential oil 0.5wt%, great Ye faint scent osmanthus
Liquid 1%wt, Tween 80 4wt%, glycerine 5wt%, sodium benzoate 0.03%, acetic acid chlorhexidine 0.1%, skin penetrant azone
0.03%, surplus is water；
S2 prepares water phase：Great Ye faint scent osmanthus concentrate, sodium benzoate, acetic acid chlorhexidine, skin penetrant azone, water are mixed
It closes uniformly, obtains water phase；
S3 prepares oil phase：Menthol, herba elsholtziae essential oil, Tween 80, glycerine are uniformly mixed, oil phase is obtained；
Oil phase is added in water phase by S4, is uniformly mixed, is obtained faint scent cassia bark skin bacteriostatic gel.
Great Ye faint scent osmanthus concentrate obtains by the following method：
(1) great Ye faint scent cassia lignea flours is broken, 60 mesh sieve is crossed, great Ye faint scent cassia lignea flour end is obtained；Add into great Ye faint scent cassia lignea flours end
Enter the ethanol water of volume fraction 80%, ethanol water weight is 15 times of great Ye faint scent cassia lignea flour end, refluxing extraction 2 hours
Afterwards, the great Ye faint scent osmanthus concentrate of relative density 1.08 is concentrated under reduced pressure to give under conditions of 65 DEG C, absolute pressure 0.03MPa；
(2) the great Ye faint scent osmanthus concentrate vacuum freeze drying for obtaining step (1), obtains great Ye faint scent osmanthus concentrate；
(3) the great Ye faint scent osmanthus concentrate that step (2) obtains is weighed, volume is dissolved under conditions of ultrasonic power 300W
In the ethanol water of score 50%, the solid-to-liquid ratio of great Ye faint scent osmanthus concentrate and ethanol water is 1：600 (g/mL), in 65
DEG C, 0.07 times of original volume is concentrated under reduced pressure under conditions of absolute pressure 0.03MPa, obtain concentrate；By concentrate with 4000
Rev/min centrifugation 10 minutes, pour out supernatant A；By supernatant A be placed in 4 DEG C place 12 hours, continue with 4000 revs/min from
The heart 10 minutes, discards precipitation, obtains supernatant B；Supernatant B is concentrated under reduced pressure under conditions of 65 DEG C, absolute pressure 0.03MPa
Obtain the great Ye faint scent osmanthus concentrate of relative density 1.08.
Great Ye faint scent osmanthus main active be alkaloid, the present invention by using different ethanol concentration ethanol water
The active constituent in great Ye faint scent osmanthus is extracted and is purified, using different material in different concentration ethanol different solubility
Property reduces great Ye faint scent osmanthus active constituent toxicity, improves bioavailability and transdermal characteristic, and reaching improves anti-inflammatory pain-stopping effect
Purpose.
The herba elsholtziae essential oil is obtained by steam distillation method：Fresh herba elsholtziae is taken, 20 mesh sieve is crushed, obtains
Herba elsholtziae powder；It weighs herba elsholtziae powder to be put into steam distillation device, water is added and so that solid-liquid ratio is 1：50 (g/mL) steam
After evaporating 180 minutes, milky emulsion is collected；The salt of its weight 7% is added into milky emulsion, is uniformly mixed
Afterwards, 20h separation is stood, upper oil phase is collected；Anhydrous sodium sulfate drying is added into upper oil phase, is used after placing 20 hours
300 mesh filter-cloth filterings, obtain herba elsholtziae essential oil.
Embodiment 4
Faint scent cassia bark skin bacteriostatic gel is prepared by the raw material of following weight ratio：Menthol 0.1wt%, herba elsholtziae essential oil
0.5wt%, great Ye faint scent osmanthus concentrate 1%wt, Tween 80 4wt%, glycerine 5wt%, sodium benzoate 0.03%, acetic acid chlorine is
Fixed 0.1%, skin penetrant azone 0.03%, Acritamer 940 1wt%, surplus is water.
The preparation method of faint scent cassia bark skin bacteriostatic gel includes the following steps：
S1 weighs following raw materials according to formula：Menthol 0.1wt%, the concentration of herba elsholtziae essential oil 0.5wt%, great Ye faint scent osmanthus
Liquid 1%wt, Tween 80 4wt%, glycerine 5wt%, sodium benzoate 0.03%, acetic acid chlorhexidine 0.1%, skin penetrant azone
0.03%, Acritamer 940 1wt%, surplus is water；
S2 prepares water phase：By great Ye faint scent osmanthus concentrate, sodium benzoate, acetic acid chlorhexidine, skin penetrant azone, card wave
Nurse 940, water are uniformly mixed, and obtain water phase；
S3 prepares oil phase：Menthol, herba elsholtziae essential oil, Tween 80, glycerine are uniformly mixed, oil phase is obtained；
Oil phase is added in water phase by S4, is uniformly mixed, is obtained the faint scent cassia bark skin bacteriostatic gel.
Great Ye faint scent osmanthus concentrate obtains by the following method：
(1) great Ye faint scent cassia lignea flours is broken, 60 mesh sieve is crossed, great Ye faint scent cassia lignea flour end is obtained；Add into great Ye faint scent cassia lignea flours end
Enter the ethanol water for the volume fraction 80% that pH is 5, ethanol water weight is 15 times of great Ye faint scent cassia lignea flour end, and reflux carries
After taking 2 hours, the great Ye faint scent osmanthus of relative density 1.08 is concentrated under reduced pressure to give under conditions of 65 DEG C, absolute pressure 0.03MPa
Concentrate；The ethanol water for the volume fraction 80% that the pH is 5 passes through acid solution by the ethanol water of volume fraction 80%
It adjusts pH to 5 to obtain, wherein acid solution is the aqueous hydrochloric acid solution of mass fraction 10%；
(2) the great Ye faint scent osmanthus concentrate vacuum freeze drying for obtaining step (1), obtains great Ye faint scent osmanthus concentrate；
(3) the great Ye faint scent osmanthus concentrate that step (2) obtains is weighed, volume is dissolved under conditions of ultrasonic power 300W
In the ethanol water of score 50%, the solid-to-liquid ratio of great Ye faint scent osmanthus concentrate and ethanol water is 1：600 (g/mL), in 65
DEG C, 0.07 times of original volume is concentrated under reduced pressure under conditions of absolute pressure 0.03MPa, obtain concentrate；By concentrate with 4000
Rev/min centrifugation 10 minutes, pour out supernatant A；By supernatant A be placed in 4 DEG C place 12 hours, continue with 4000 revs/min from
The heart 10 minutes, discards precipitation, obtains supernatant B；Supernatant B is concentrated under reduced pressure under conditions of 65 DEG C, absolute pressure 0.03MPa
Obtain the great Ye faint scent osmanthus concentrate of relative density 1.08.
Active constituent extraction also is carried out to great Ye faint scent osmanthus using acid ethanol water in the present invention, it is clear to improve great Ye
The leaching rate of the active bio alkali composition of fragrant osmanthus.
The herba elsholtziae essential oil is obtained by steam distillation method：Fresh herba elsholtziae is taken, 20 mesh sieve is crushed, obtains
Herba elsholtziae powder；It weighs herba elsholtziae powder to be put into steam distillation device, water is added and so that solid-liquid ratio is 1：50 (g/mL) steam
After evaporating 180 minutes, milky emulsion is collected；The salt of its weight 7% is added into milky emulsion, is uniformly mixed
Afterwards, 20h separation is stood, upper oil phase is collected；Anhydrous sodium sulfate drying is added into upper oil phase, is used after placing 20 hours
300 mesh filter-cloth filterings, obtain herba elsholtziae essential oil.
Embodiment 5
Faint scent cassia bark skin bacteriostatic gel is prepared by the raw material of following weight ratio：Menthol 0.1wt%, herba elsholtziae essential oil
0.5wt%, great Ye faint scent osmanthus concentrate 1%wt, Tween 80 4wt%, glycerine 5wt%, sodium benzoate 0.03%, acetic acid chlorine is
Fixed 0.1%, skin penetrant azone 0.03%, Acritamer 940 1wt%, surplus is water.
The preparation method of faint scent cassia bark skin bacteriostatic gel includes the following steps：
S1 weighs following raw materials according to formula：Menthol 0.1wt%, the concentration of herba elsholtziae essential oil 0.5wt%, great Ye faint scent osmanthus
Liquid 1%wt, Tween 80 4wt%, glycerine 5wt%, sodium benzoate 0.03%, acetic acid chlorhexidine 0.1%, skin penetrant azone
0.03%, Acritamer 940 1wt%, surplus is water；
S2 prepares water phase：By great Ye faint scent osmanthus concentrate, sodium benzoate, acetic acid chlorhexidine, skin penetrant azone, card wave
Nurse 940, water are uniformly mixed, and obtain water phase；
S3 prepares oil phase：Menthol, herba elsholtziae essential oil, Tween 80, glycerine are uniformly mixed, oil phase is obtained；
Oil phase is added in water phase by S4, is uniformly mixed, is obtained the faint scent cassia bark skin bacteriostatic gel.
Great Ye faint scent osmanthus concentrate obtains by the following method：
(1) great Ye faint scent cassia lignea flours is broken, 60 mesh sieve is crossed, great Ye faint scent cassia lignea flour end is obtained；Add into great Ye faint scent cassia lignea flours end
Enter the ethanol water for the volume fraction 80% that pH is 5, ethanol water weight is 15 times of great Ye faint scent cassia lignea flour end, and reflux carries
After taking 2 hours, the great Ye faint scent osmanthus of relative density 1.08 is concentrated under reduced pressure to give under conditions of 65 DEG C, absolute pressure 0.03MPa
Concentrate；The ethanol water for the volume fraction 80% that the pH is 5 passes through acid solution by the ethanol water of volume fraction 80%
It adjusts pH to 5 to obtain, wherein acid solution is the aqueous hydrochloric acid solution of mass fraction 10%；
(2) the great Ye faint scent osmanthus concentrate vacuum freeze drying for obtaining step (1), obtains great Ye faint scent osmanthus concentrate；
(3) the great Ye faint scent osmanthus concentrate that step (2) obtains is weighed, volume is dissolved under conditions of ultrasonic power 300W
In the ethanol water of score 50%, the solid-to-liquid ratio of great Ye faint scent osmanthus concentrate and ethanol water is 1：600 (g/mL), in 65
DEG C, 0.07 times of original volume is concentrated under reduced pressure under conditions of absolute pressure 0.03MPa, obtain concentrate；By concentrate with 4000
Rev/min centrifugation 10 minutes, pour out supernatant A；By supernatant A be placed in 4 DEG C place 12 hours, continue with 4000 revs/min from
The heart 10 minutes, discards precipitation, obtains supernatant B；Supernatant B is concentrated under reduced pressure under conditions of 65 DEG C, absolute pressure 0.03MPa
Obtain the great Ye faint scent osmanthus concentrate of relative density 1.08.
The herba elsholtziae essential oil obtains by the following method：Fresh herba elsholtziae is taken, 20 mesh sieve is crushed, obtains herba elsholtziae
Powder；It weighs herba elsholtziae powder to be put into steam distillation device, water is added and so that solid-liquid ratio is 1：50 (g/mL), distillation 180
After minute, milky emulsion is collected；The salt of its weight 7% is added into milky emulsion, it is after mixing, quiet
20h separation is set, upper oil phase is collected；Anhydrous sodium sulfate drying is added into upper oil phase, is filtered using 300 mesh after placing 20 hours
Cloth filters, and obtains herba elsholtziae oil；Attapulgite is roasted 1 hour in 400 DEG C, the attapulgite after being activated；After taking activation
Attapulgite 5g be added in deionized water 800mL, ultrasonic disperse 25 minutes, obtains bumps under conditions of ultrasonic power 300W
Stick stone suspension；It takes herba elsholtziae oil 2g to be dissolved in 100mL absolute ethyl alcohols, is then added in 300mL attapulgite suspension, in
80 DEG C are stirred 150 minutes with 100 revs/min, are centrifuged 10 minutes with 8000 revs/min, and bottom solid is collected；Bottom solid is used
The ethanol water that the volume fraction of 200 times of its weight is 50% washs, and is centrifuged 10 minutes, is precipitated with 8000 revs/min；
80 DEG C of dryings will be deposited in constant weight, ground 200 mesh sieve to get.
Herba elsholtziae essential oil is modified using attapulgite, herba elsholtziae essential oil is adsorbed on bumps in a manner of physical absorption
The surface of stick stone, forms the compound of attapulgite and herba elsholtziae essential oil, which can adsorb bacterium and pass through chemical bond
Mode it is combined with it, apparent bacteriostasis property shown to strains such as Escherichia coli and staphylococcus aureuses, and stablize
Property is improved.
Embodiment 6
Faint scent cassia bark skin bacteriostatic gel, is prepared by the raw material of following weight ratio：Menthol 0.1wt%, herba elsholtziae essence
Oily 0.5wt%, great Ye faint scent osmanthus concentrate 1%wt, Tween 80 4wt%, glycerine 5wt%, sodium benzoate 0.03%, acetic acid chlorine
Determine 0.1%, skin penetrant azone 0.03%, Acritamer 940 1wt%, surplus is water.
The preparation method of faint scent cassia bark skin bacteriostatic gel includes the following steps：
S1 weighs following raw materials according to formula：Menthol 0.1wt%, the concentration of herba elsholtziae essential oil 0.5wt%, great Ye faint scent osmanthus
Liquid 1%wt, Tween 80 4wt%, glycerine 5wt%, sodium benzoate 0.03%, acetic acid chlorhexidine 0.1%, skin penetrant azone
0.03%, Acritamer 940 1wt%, surplus is water；
S2 prepares water phase：By great Ye faint scent osmanthus concentrate, sodium benzoate, acetic acid chlorhexidine, skin penetrant azone, card wave
Nurse 940, water are uniformly mixed, and obtain water phase；
S3 prepares oil phase：Menthol, herba elsholtziae essential oil, Tween 80, glycerine are uniformly mixed, oil phase is obtained；
Oil phase is added in water phase by S4, is uniformly mixed, is obtained the faint scent cassia bark skin bacteriostatic gel.
Great Ye faint scent osmanthus concentrate obtains by the following method：
(1) great Ye faint scent cassia lignea flours is broken, 60 mesh sieve is crossed, great Ye faint scent cassia lignea flour end is obtained；Add into great Ye faint scent cassia lignea flours end
Enter the ethanol water for the volume fraction 80% that pH is 5, ethanol water weight is 15 times of great Ye faint scent cassia lignea flour end, and reflux carries
After taking 2 hours, the great Ye faint scent osmanthus of relative density 1.08 is concentrated under reduced pressure to give under conditions of 65 DEG C, absolute pressure 0.03MPa
Concentrate；The ethanol water for the volume fraction 80% that the pH is 5 passes through acid solution by the ethanol water of volume fraction 80%
It adjusts pH to 5 to obtain, wherein acid solution is the boric acid aqueous solution of mass fraction 10%；
(2) the great Ye faint scent osmanthus concentrate vacuum freeze drying for obtaining step (1), obtains great Ye faint scent osmanthus concentrate；
(3) the great Ye faint scent osmanthus concentrate that step (2) obtains is weighed, volume is dissolved under conditions of ultrasonic power 300W
In the ethanol water of score 50%, the solid-to-liquid ratio of great Ye faint scent osmanthus concentrate and ethanol water is 1：600 (g/mL), in 65
DEG C, 0.07 times of original volume is concentrated under reduced pressure under conditions of absolute pressure 0.03MPa, obtain concentrate；By concentrate with 4000
Rev/min centrifugation 10 minutes, pour out supernatant A；By supernatant A be placed in 4 DEG C place 12 hours, continue with 4000 revs/min from
The heart 10 minutes, discards precipitation, obtains supernatant B；Supernatant B is concentrated under reduced pressure under conditions of 65 DEG C, absolute pressure 0.03MPa
Obtain the great Ye faint scent osmanthus concentrate of relative density 1.08.
The herba elsholtziae essential oil obtains by the following method：Fresh herba elsholtziae is taken, 20 mesh sieve is crushed, obtains herba elsholtziae
Powder；It weighs herba elsholtziae powder to be put into steam distillation device, water is added and so that solid-liquid ratio is 1：50 (g/mL), distillation 180
After minute, milky emulsion is collected；The salt of its weight 7% is added into milky emulsion, it is after mixing, quiet
20h separation is set, upper oil phase is collected；Anhydrous sodium sulfate drying is added into upper oil phase, is filtered using 300 mesh after placing 20 hours
Cloth filters, and obtains herba elsholtziae oil；Attapulgite is roasted 1 hour in 400 DEG C, the attapulgite after being activated；After taking activation
Attapulgite 5g be added in deionized water 800mL, ultrasonic disperse 25 minutes, obtains bumps under conditions of ultrasonic power 300W
Stick stone suspension；It takes herba elsholtziae oil 2g to be dissolved in 100mL absolute ethyl alcohols, is then added in 300mL attapulgite suspension, in
80 DEG C are stirred 150 minutes with 100 revs/min, are centrifuged 10 minutes with 8000 revs/min, and bottom solid is collected；Bottom solid is used
The ethanol water that the volume fraction of 200 times of its weight is 50% washs, and is centrifuged 10 minutes, is precipitated with 8000 revs/min；
80 DEG C of dryings will be deposited in constant weight, ground 200 mesh sieve to get.
Embodiment 7
Faint scent cassia bark skin bacteriostatic gel, is prepared by the raw material of following weight ratio：Menthol 0.1wt%, herba elsholtziae essence
Oily 0.5wt%, great Ye faint scent osmanthus concentrate 1%wt, Tween 80 4wt%, glycerine 5wt%, sodium benzoate 0.03%, acetic acid chlorine
Determine 0.1%, skin penetrant azone 0.03%, Acritamer 940 1wt%, surplus is water.
The preparation method of faint scent cassia bark skin bacteriostatic gel includes the following steps：
S1 weighs following raw materials according to formula：Menthol 0.1wt%, the concentration of herba elsholtziae essential oil 0.5wt%, great Ye faint scent osmanthus
Liquid 1%wt, Tween 80 4wt%, glycerine 5wt%, sodium benzoate 0.03%, acetic acid chlorhexidine 0.1%, skin penetrant azone
0.03%, Acritamer 940 1wt%, surplus is water；
S2 prepares water phase：By great Ye faint scent osmanthus concentrate, sodium benzoate, acetic acid chlorhexidine, skin penetrant azone, card wave
Nurse 940, water are uniformly mixed, and obtain water phase；
S3 prepares oil phase：Menthol, herba elsholtziae essential oil, Tween 80, glycerine are uniformly mixed, oil phase is obtained；
Oil phase is added in water phase by S4, is uniformly mixed, is obtained the faint scent cassia bark skin bacteriostatic gel.
Great Ye faint scent osmanthus concentrate obtains by the following method：
(1) great Ye faint scent cassia lignea flours is broken, 60 mesh sieve is crossed, great Ye faint scent cassia lignea flour end is obtained；Add into great Ye faint scent cassia lignea flours end
Enter the ethanol water for the volume fraction 80% that pH is 5, ethanol water weight is 15 times of great Ye faint scent cassia lignea flour end, and reflux carries
After taking 2 hours, the great Ye faint scent osmanthus of relative density 1.08 is concentrated under reduced pressure to give under conditions of 65 DEG C, absolute pressure 0.03MPa
Concentrate；The ethanol water for the volume fraction 80% that the pH is 5 passes through acid solution by the ethanol water of volume fraction 80%
Adjust pH to 5 obtain, wherein acid solution be mass fraction 10% boric acid aqueous solution and mass fraction 10% aqueous hydrochloric acid solution with
Mass ratio 4：The mixture of 1 composition；
(2) the great Ye faint scent osmanthus concentrate vacuum freeze drying for obtaining step (1), obtains great Ye faint scent osmanthus concentrate；
(3) the great Ye faint scent osmanthus concentrate that step (2) obtains is weighed, volume is dissolved under conditions of ultrasonic power 300W
In the ethanol water of score 50%, the solid-to-liquid ratio of great Ye faint scent osmanthus concentrate and ethanol water is 1：600 (g/mL), in 65
DEG C, 0.07 times of original volume is concentrated under reduced pressure under conditions of absolute pressure 0.03MPa, obtain concentrate；By concentrate with 4000
Rev/min centrifugation 10 minutes, pour out supernatant A；By supernatant A be placed in 4 DEG C place 12 hours, continue with 4000 revs/min from
The heart 10 minutes, discards precipitation, obtains supernatant B；Supernatant B is concentrated under reduced pressure under conditions of 65 DEG C, absolute pressure 0.03MPa
Obtain the great Ye faint scent osmanthus concentrate of relative density 1.08.
The herba elsholtziae essential oil obtains by the following method：Fresh herba elsholtziae is taken, 20 mesh sieve is crushed, obtains herba elsholtziae
Powder；It weighs herba elsholtziae powder to be put into steam distillation device, water is added and so that solid-liquid ratio is 1：50 (g/mL), distillation 180
After minute, milky emulsion is collected；The salt of its weight 7% is added into milky emulsion, it is after mixing, quiet
20h separation is set, upper oil phase is collected；Anhydrous sodium sulfate drying is added into upper oil phase, is filtered using 300 mesh after placing 20 hours
Cloth filters, and obtains herba elsholtziae oil；Attapulgite is roasted 1 hour in 400 DEG C, the attapulgite after being activated；After taking activation
Attapulgite 5g be added in deionized water 800mL, ultrasonic disperse 25 minutes, obtains bumps under conditions of ultrasonic power 300W
Stick stone suspension；It takes herba elsholtziae oil 2g to be dissolved in 100mL absolute ethyl alcohols, is then added in 300mL attapulgite suspension, in
80 DEG C are stirred 150 minutes with 100 revs/min, are centrifuged 10 minutes with 8000 revs/min, and bottom solid is collected；Bottom solid is used
The ethanol water that the volume fraction of 200 times of its weight is 50% washs, and is centrifuged 10 minutes, is precipitated with 8000 revs/min；
80 DEG C of dryings will be deposited in constant weight, ground 200 mesh sieve to get.
Effect example 1
The stability of the faint scent cassia bark skin bacteriostatic gel of Examples 1 to 7 is tested.
(1) centrifugal test
The faint scent cassia bark skin bacteriostatic gel sample 40g of each Example 1~7 is placed in centrifuge tube, then with 4000 revs/min
Centrifugation 30 minutes, gel is not stratified.
The faint scent cassia bark skin bacteriostatic gel sample 40g of each Example 1~7, which is placed in 50 DEG C of insulating boxs, to be placed 24 hours
Afterwards, it is placed in centrifuge tube, then is centrifuged 30 minutes with 4000 revs/min, gel is not stratified.
The faint scent cassia bark skin bacteriostatic gel sample 40g of each Example 1~7 is placed in 4 DEG C of refrigerators place 24 hours after, set
It is centrifuged 30 minutes in centrifuge tube, then with 4000 revs/min, gel is not stratified.
(2) reserved sample observing
The faint scent cassia bark skin bacteriostatic gel sample of each Example 1~7 makees reserved sample observing, is placed in 25 DEG C, relative humidity
It is placed 3 months in 60% environment, the uniformity, transparency, acid-base value, consistency of gel etc. are not substantially change and not mould
Become phenomenon.
Effect example 2
The In Vitro Bacteriostasis performance of the faint scent cassia bark skin bacteriostatic gel of embodiment 7 is measured, with reference to Han Aixia《Cassia twig body
Outer bacteriostasis research》When treasure's traditional Chinese medical science traditional Chinese medicines, 2004,15 (11):743 carry out.Test result is shown in Table 1.
1 In Vitro Bacteriostasis results of property table of table
As it can be seen from table 1 the faint scent cassia bark skin bacteriostatic gel that the present invention obtains is to clinical common large intestine Erichsen bacterium, gold
Staphylococcus aureus, pseudomonas aeruginosa have bacteriostasis.Skin infection and empyrosis majority are by P. aeruginosa
Microbial, faint scent cassia bark skin bacteriostatic gel of the present invention has clinical multi-resistant Pseudomonas aeruginosa significant antibacterial
Effect, it is sufficient to illustrate that faint scent cassia bark skin bacteriostatic gel of the present invention is scalded to burning soup, there is scytitis significant treatment to make
With.
Effect example 3
The anti-inflammatory performance of the faint scent cassia bark skin bacteriostatic gel of embodiment 2~7 is tested.
(1) caused by dimethylbenzene xylene ear swelling is anti-inflammatory
1, experimental animal：Cleaning grade ICR mouse, 18~22g of weight, half male and half female, by Beijing dimension tonneau China experimental animal
Technology Co., Ltd. provides.Before experiment, all experimental animals, which are grouped, is put into adaptability raising 7 days, temperature 20 in plastics mouse cage
~24 DEG C, humidity 40~60%, the common mouse pellet of feeding and tap water, fasting 12 hours, free water before being administered.
2, experiment grouping：Test mice is grouped at random, every group 10.Test group uses the faint scent prepared in embodiment 2~7
Cassia bark skin bacteriostatic gel, control group use the PBS solution of pH7.4.
3, test operation：Mouse right ear is smeared into woods dimethylbenzene, left ear does not apply as a contrast, after 30 minutes, tests each group
Two ear of mouse or so smears corresponding faint scent cassia bark skin bacteriostatic gel, and blank group gives the PBS solution of equivalent.It is administered 3 times altogether,
80 μ L every time, every minor tick 10 minutes.Last dose after forty minutes puts to death mouse cervical dislocation, and left and right two is cut along auricle
Ear lays round auricle in two ear same areas of left and right with the card punch of diameter 6mm, weighs.
Ear swelling degree and the calculation formula for pressing down the rate of swelling are：
Ear swelling degree=auris dextra weight-left ear weight；
Suppression rate=(blank group be averaged ear swelling degree-test group be averaged ear swelling the degree)/blank group that swells is averaged ear swelling degree.
It the results are shown in Table 2.
2 faint scent cassia bark skin bacteriostatic gel paraxylene of table causes the anti-inflammatory effect of ear swelling
(2) immunity is anti-inflammatory
1, experimental animal：Cleaning grade ICR mouse, 18~22g of weight, half male and half female, by Beijing dimension tonneau China experimental animal
Technology Co., Ltd. provides.Before experiment, all experimental animals, which are grouped, is put into adaptability raising 7 days, temperature 20 in plastics mouse cage
~24 DEG C, humidity 40~60%, the common mouse pellet of feeding and tap water, fasting 12 hours, free water before being administered.
2, experiment grouping：Test mice is grouped at random, every group 10.Test group uses the faint scent prepared in embodiment 2~7
Cassia bark skin bacteriostatic gel, control group use the PBS solution of pH7.4.
3, the preparation of dinitro-chlorine benzole soln：Dinitrofluorobenzene about 0.3g is taken, it is accurately weighed, it is settled to 10mL with acetone and holds
In measuring bottle, it is made into a concentration of 3% dinitro-chlorine benzole soln.
4, test operation：Mouse web portion is administered first 24 hours and scrapes unhairing, area about 2 × 2cm with the blade after lubrication2.It gives
When medicine, test group takes 60 μ L of faint scent cassia bark skin bacteriostatic gel to be uniformly applied to mouse web portion, and blank group smears the PBS solution of equivalent.
Daily every group is administered once, successive administration 10 days.
After administration in first day, the 50 μ L of dinitro-chlorine benzole soln of every group of mouse microsyringe dorsal sc injection 3%
Sensitization, after being administered at the 4th day, same operation is strengthened primary again.
The generation of delayed allergy and measurement：It is administered the 10th day, 1% dinitro-chlorine benzole soln, 20 μ L is applied to mouse
Auris dextra two sides is attacked.24 hours after attack, cervical dislocation puts to death mouse, left and right auricular concha is cut, with the card punch of diameter 6mm
Auricle, scales/electronic balance weighing are removed at identical position.
Ear swelling degree=auris dextra weight-left ear weight.
It the results are shown in Table 3.
The effect anti-inflammatory to immunity of 3 faint scent cassia bark skin bacteriostatic gel of table
Effect example 4
The analgesic activity of the faint scent cassia bark skin bacteriostatic gel of embodiment 2~7 is tested.
(1) mouse acetic acid twisting analgesic response
1, experimental animal：Cleaning grade ICR mouse, 18~22g of weight, half male and half female, by Beijing dimension tonneau China experimental animal
Technology Co., Ltd. provides.Before experiment, all experimental animals, which are grouped, is put into adaptability raising 7 days, temperature 20 in plastics mouse cage
~24 DEG C, humidity 40~60%, the common mouse pellet of feeding and tap water, fasting 12 hours, free water before being administered.
2, experiment grouping：Test mice is grouped at random, every group 10.Test group uses the faint scent prepared in embodiment 2~7
Cassia bark skin bacteriostatic gel, control group use the PBS solution of pH7.4.
3, test operation：First 24 hours of experiment is lost hair or feathers to mouse web portion, 2 × 2cm of depilation area2, spare.It is dynamic in every group
Object abdomen smears 60 μ L faint scent cassia bark skin bacteriostatic gels, and blank control group smears equivalent PBS solution.Altogether be administered 3 times, every time between
Every 10 minutes.0.6% acetum is injected intraperitoneally according to the dosage of 0.02mL/g respectively in each group mouse after last dose 45 minutes,
There is the number of writhing response in mouse in observation 25 minutes, records, and calculate analgesia percentage.
Analgesia percentage=(control group be averaged one test group of writhing number be averaged writhing number)/control group writhing that is averaged is secondary
Number.
It the results are shown in Table 4.
The analgesic activity of 4 faint scent cassia bark skin bacteriostatic gel Dichlorodiphenyl Acetate writhing of table
(2) mouse hot-plate analgesic response
1, experimental animal：Cleaning grade ICR mouse, 18~22g of weight, half male and half female, by Beijing dimension tonneau China experimental animal
Technology Co., Ltd. provides.Before experiment, all experimental animals, which are grouped, is put into adaptability raising 7 days, temperature 20 in plastics mouse cage
~24 DEG C, humidity 40~60%, the common mouse pellet of feeding and tap water, fasting 12 hours, free water before being administered.
2, experiment grouping：Test mice is grouped at random, every group 10.Test group uses the faint scent prepared in embodiment 2~7
Cassia bark skin bacteriostatic gel, control group use the PBS solution of pH7.4.
3, test operation：The rosette of one piece of diameter 10cm is put into 55 scholar, 0.5 DEG C of water-bath, one is placed on disk
Mouse is placed on disk rapidly by the glass cylinder of a 15cm high, when measurement, the timing since touching rosette, until dynamic
Object licks metapedes or jumps out of rosette.It is such as still reactionless more than 30 seconds, then mouse is taken out to prevent animal of burning immediately, and count
For the reaction time (s).
First 24 hours of experiment is lost hair or feathers to mouse web portion, 2 × 2cm of depilation area2, spare.Before administration, each group mouse is measured
The basic reaction time (s).60 μ L faint scent cassia bark skin bacteriostatic gels are smeared in test group mouse web portion, control group smears equivalent
PBS solution.It is administered 3 times altogether, every minor tick 10 minutes, last dose measures its reaction time in 45 minutes again.
It the results are shown in Table 5.
5 faint scent cassia bark skin bacteriostatic gel of the table analgesic activity pain caused to hot plate
Effect example 5
Tests For Irritating Effects are carried out to the faint scent cassia bark skin bacteriostatic gel of embodiment 1.
Female New Zealand rabbit 6,2.0~2.5kg of weight is taken, is divided into tested group and control group, every group 3.It will lead
Pipe is soft to inject 4~5cm of vagina, and film 2mL faint scent cassia bark skin bacteriostatic gels.Control animals are made same using physiological saline
Processing.Aeroembolism method puts to death animal after 24 hours, takes out complete vagina, is fixed on after longitudinally slit 24 in 10% formalin solution
Hour or more, the tissue film-making in vagina center and 3, both ends position is chosen, stimulate the reaction scoring evaluation is carried out.
Stimulate the reaction scoring is shown in Table 6.
6 stimulate the reaction appraisal result table of table
In above-mentioned table, the calculation of average integral is：The sum of average integral=3 animal stimulate the reaction scoring/observation
Animal number of elements；The calculation of stimulus index is：Stimulus index=tested group-control group average integral.
As can be seen from Table 6, a vagina of the faint scent cassia bark skin bacteriostatic gel of the present invention to Female New Zealand rabbit
Viscosity irritation is extremely light.
It should be appreciated that although this specification is described in terms of embodiments, but not each embodiment only includes one
A independent technical solution, this narrating mode of specification are used for the purpose of for the sake of understanding, those skilled in the art should incite somebody to action
As a whole, the technical solutions in the various embodiments may also be suitably combined for specification, and forming those skilled in the art can
With the other embodiment of understanding.
Claims (8)
1. faint scent cassia bark skin bacteriostatic gel, which is characterized in that including following raw materials：Menthol, herba elsholtziae essential oil, great Ye faint scent osmanthus
Concentrate, Tween 80, glycerine, Acritamer 940, water.
2. faint scent cassia bark skin bacteriostatic gel according to claim 1, which is characterized in that include the raw material of following weight ratio：
0.1~0.3wt% of menthol, herba elsholtziae essential oil 0.5~2wt%, great Ye faint scent osmanthus 1~5wt% of concentrate, Tween 80 4~
6wt%, 5~10wt% of glycerine, 0.5~1.5wt% of Acritamer 940, surplus are water.
3. faint scent cassia bark skin bacteriostatic gel according to claim 2, which is characterized in that the weight ratio of the herba elsholtziae essential oil
Preferably 0.5wt%.
4. faint scent cassia bark skin bacteriostatic gel according to claim 2, which is characterized in that great Ye faint scent osmanthus concentrate
Weight ratio is preferably 1wt%.
5. faint scent cassia bark skin bacteriostatic gel according to claim 2, which is characterized in that the weight ratio of the Acritamer 940
Preferably 1wt%.
6. faint scent cassia bark skin bacteriostatic gel according to claim 2, which is characterized in that prepared by the raw material of following weight ratio
It forms：0.1~0.3wt% of menthol, herba elsholtziae essential oil 0.5~2wt%, great Ye faint scent osmanthus 1~5wt% of concentrate, Tween 80
4~6wt%, 5~10wt% of glycerine, 0.01~0.1wt% of preservative, acetic acid 0.1~0.3wt% of chlorhexidine, skin penetrant
0.01~0.05wt% of azone, 0.5~1.5wt% of Acritamer 940, surplus are water.
7. the faint scent cassia bark skin bacteriostatic gel according to claim 2 or 6, which is characterized in that the weight ratio of the menthol
The weight ratio of preferably 0.1wt%, the Tween 80 are preferably 4wt%, and the weight ratio of the glycerine is preferably 5wt%.
8. the preparation method of faint scent cassia bark skin bacteriostatic gel according to claim 6, which is characterized in that including following step
Suddenly：
S1 weighs following raw materials according to formula：0.1~0.3wt% of menthol, herba elsholtziae essential oil 0.5~2wt%, great Ye faint scent osmanthus
1~5wt% of concentrate, 4~6wt% of Tween 80,5~10wt% of glycerine, 0.01~0.1wt% of preservative, acetic acid chlorhexidine
0.1~0.3wt%, skin penetrant 0.01~0.05wt% of azone, 0.5~1.5wt% of Acritamer 940, surplus is water；
S2 prepares water phase：By great Ye faint scent osmanthus concentrate, preservative, acetic acid chlorhexidine, skin penetrant azone, Acritamer 940,
Water is uniformly mixed, and obtains water phase；
S3 prepares oil phase：Menthol, herba elsholtziae essential oil, Tween 80, glycerine are uniformly mixed, oil phase is obtained；
Oil phase is added in water phase by S4, is uniformly mixed, is obtained faint scent cassia bark skin bacteriostatic gel.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112156027A (en) * | 2020-10-27 | 2021-01-01 | 广州德芙化妆品有限公司 | Sunscreen cream with high sun protection value and preparation method thereof |
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| US20010001665A1 (en) * | 1999-02-11 | 2001-05-24 | Marie Harbeck | Cream compositions for skin management |
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| CN112156027A (en) * | 2020-10-27 | 2021-01-01 | 广州德芙化妆品有限公司 | Sunscreen cream with high sun protection value and preparation method thereof |
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