CN108783471A - A kind of dietary composition and preparation method thereof of Reduce allergy purpura disease - Google Patents
A kind of dietary composition and preparation method thereof of Reduce allergy purpura disease Download PDFInfo
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- CN108783471A CN108783471A CN201810697953.6A CN201810697953A CN108783471A CN 108783471 A CN108783471 A CN 108783471A CN 201810697953 A CN201810697953 A CN 201810697953A CN 108783471 A CN108783471 A CN 108783471A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
The present invention relates to a kind of dietary compositions and preparation method thereof of Reduce allergy purpura disease.The dietary composition, by weight, including 16-25 parts of rice starch, 10-14 parts of food fibre powder, 9-16 parts of plant fat powder, 8-13 parts of albumen powder, 1-7 parts of vitamin and mineral, 1-2 parts of stabilizer.Dietary composition prepared by the present invention is scientifically on the basis of food fibre powder, allocate other nutritional ingredients, such as albumen powder, plant fat powder, vitamin and mineral etc., nutritional ingredient acts synergistically, demand of the comprehensive guarantee anaphylactoid purpura body to nutritional ingredient and energy, suitable for the nutrient imbalance caused by anaphylactoid purpura, the crowd of metabolic disorder, this dietary composition is mixed using nutrition-allocated proportion, ensure that diet energy is sufficient, while alleviating electrolyte imbalance, science adjusts Intestinal Mucosal Injury in Patients Undergoing flora, improve function of intestinal canal, play maintenance intestinal health, improve immunity of organisms.
Description
Technical field
The present invention relates to a kind of dietary compositions and preparation method thereof of Reduce allergy purpura disease, belong to functional food
Product field.
Background technology
Anaphylactoid purpura is a kind of capilary allergy for invading skin and the tiny artery of other organs and capillary
Property haemorrhage, main clinical manifestation symptom is gastrointestinal symptom, skin symptom, joint symptoms and renal symptom, but blood platelet is not
It reduces.Children and teenager are common, and male is common compared with women.Cause the factor that anaphylactoid purpura occurs numerous, such as cause of disease body-sensing
Dye, food hypersenstivity, drug allergy, pollen hypersensitivity, insect bite allergy etc..
The drug therapy of anaphylactoid purpura generally has Fenbid, anisodamine (oral or intramuscular injection), atropine (flesh at present
Note), even antibiotic, cortex hormone of aadrenaline etc..One side drug can bring certain side effect even dependence to patient,
It is not recommended that exaggerated drug is treated, while anaphylactogen is determined because being often difficult to；On the other hand when the stomach and intestine work(brought by disease itself
When can be abnormal, the microecosystem of enteron aisle can be destroyed seriously, and beneficial bacterium/conditioned pathogen ratio significantly increases, in turn
Gastrointestinal disturbances disorder, electrolyte imbalance, nutritional deficiency etc. are aggravated, the exacerbation of the anaphylactoid purpura state of an illness is further resulted in.
Chinese patent literature CN104667020A (application number CN201510125642.9) discloses a kind of pharmaceutical composition,
The pharmaceutical composition includes active constituent and pharmaceutically acceptable auxiliary material, and the active constituent is by desmodium, plantain seed, sea
Jinsha, corn stigma, oldenlandia diffusa, cordate houttuynia, rhizoma imperatae, jingle bell beans, Radix Salviae Miltiorrhizae, safflower, peach kernel, Herba Lycopi, dianthus superbus, motherwort,
Caulis Spatholobi, China rose, panax japonicus majoris, the root bark of tree peony, radix scrophulariae, radix paeoniae rubra, Asian puccoon, radix cynanchi atrati, radix rehmanniae recen, eclipta, rhizoma anemarrhenae, radix scutellariae, Fructus Forsythiae and
Adder-wort is prepared.Chinese patent literature CN103768395A (application number CN201410048873.X) discloses a kind of Chinese medicine system
Agent, said preparation select Chinese medicine indian abution root, round-pinna maidenhair herb, dayflower, japanese claw fern herb, broom top, longflower stringbush root, cowpea, Shi Feng
Pellet, largespike woodnettle root, littleleaf willow root and leaf, decocting is at decoction.It is above-mentioned in the prior art, be all to be treated in a manner of drug, it is difficult to overcome
The side effect that medicine band is come even dependence, does not improve diet structure and the nutrition of patients with anaphylactoid purpura, cannot achieve
The reconstruction of body intestinal microecology system and comprehensive demand to nutritional ingredient.
Invention content
In view of the deficiencies of the prior art, the present invention provides a kind of dietary composition of Reduce allergy purpura disease and its
Preparation method.
The technical solution adopted by the present invention is as follows：
A kind of dietary composition of Reduce allergy purpura disease, by weight, including 16-25 parts of rice starch, meals
Eat 10-14 parts of fiber powder, 9-16 parts of plant fat powder, 8-13 parts of albumen powder, 1-7 parts of vitamin and mineral, stabilizer 1-2
Part；
Wherein, the food fibre powder is by licorice powder, xylo-oligosaccharide, Poria cocos powder by weight (1-2)：(0.75-
1.4)：1 composition；It is (0.3-1.5) by weight that the plant fat powder, which is by linseed meal and Qi Ya seeds powder,：1 composition；Institute
State the mixing that albumen powder is PURE WHEY or casoid flour or its arbitrary weight ratio.
According to a kind of currently preferred, above-mentioned dietary composition of Reduce allergy purpura disease, by weight, packet
Include 18-23 parts of rice starch, 11-14 parts of food fibre powder, 9-13 parts of plant fat powder, 9-11 parts of albumen powder, vitamin and mine
1-4 parts of substance, 1-2 parts of stabilizer.
It is to be by weight by licorice powder, xylo-oligosaccharide, Poria cocos powder according to currently preferred, described food fibre powder
1.5 ﹕, 1.2 ﹕ 1 compositions；It is (1 group of 0.7-1.3) ﹕ by weight that the plant fat powder, which is by linseed meal and strange sub- seed powder,
At wherein Omega-3 unsaturated fatty acid contents are not less than 18% in the strange sub- seed powder；The albumen powder is by lactalbumin
It is by weight with casein (0.9-1.4)：1 composition.
According to currently preferred, Omega-3 unsaturated fatty acid contents are in 18%-28% in the strange sub- seed powder.
According to currently preferred, the vitamin and mineral, by weight, by vitamin A 0.0033-
0.0058 part, 0.0021-0.0066 parts of vitamin D, 0.066-0.3 parts of vitamin E, vitamin K1 0.00018-0.00044
Part, 0.0037-0.026 parts of vitamin B, 0.49-0.78 parts of vitamin C, 0.015-0.046 parts of niacin, folic acid 0.0041-
0.0059 part, 0.038-0.076 parts of pantothenic acid, 0.00015-0.00038 parts of biotin, 0.05-0.52 parts of sodium, potassium 0.05-0.52
Part, 0.011-0.063 parts of copper, 0.083-0.097 parts of magnesium, 0.032-0.085 parts of iron, 0.014-0.059 parts of zinc, manganese 0.041-
0.062 part, 0.2-0.56 parts of calcium, 0.011-0.85 parts of phosphorus, 0.0003-0.0008 parts of iodine, 0.01-0.08 parts of chlorine, selenium 0.0002-
0.0004 part of composition.
It is further preferred that the vitamin and mineral, by weight, by 0.004-0.005 parts of vitamin A, dimension
Raw 0.0035-0.0061 parts of element D, 0.072-0.29 parts of vitamin E, 0.0002-0.00034 parts of vitamin K1, vitamin B
0.0044-0.017 parts, 0.55-0.7 parts of vitamin C, 0.023-0.033 parts of niacin, 0.0057-0.0059 parts of folic acid, pantothenic acid
0.042-0.063 parts, 0.0002-0.0003 parts of biotin, 0.05-0.34 parts of sodium, 0.05-0.34 parts of potassium, copper 0.028-0.06
Part, 0.093-0.096 parts of magnesium, 0.057-0.062 parts of iron, 0.03-0.05 parts of zinc, 0.045-0.06 parts of manganese, 0.3-0.5 parts of calcium,
0.0002-0.00033 parts of 0.04-0.8 parts of phosphorus, 0.0004-0.00065 parts of iodine, 0.01-0.04 parts of chlorine, selenium compositions.
According to currently preferred, the stabilizer is the mixed of sodium alginate or maltodextrin or its any weight ratio
It closes；Further preferably sodium alginate.
A kind of preparation method of the dietary composition of above-mentioned Reduce allergy purpura disease, includes the following steps：
(1) vitamin and mineral is proportionally mixed with stabilizer, obtains the first mixture；
(2) it weighs and is mixed with the first mixture with the rice starch of the first mixture equivalent, obtain the second mixture；
(3) it weighs and continues to mix with the second mixture with the rice starch of the second mixture equivalent, obtain third mixture；
(4) remaining rice starch is mixed with third mixture, obtains the 4th mixture；
(5) it after being sufficiently mixed plant fat powder, is mixed with the 4th mixture, obtains the 5th mixture；
(6) remaining component is mixed after drying with the 5th mixture, sterilizes, pelletizes, the anaphylactoid purpura that is eased disease
The dietary composition of disease.
According to currently preferred, in above-mentioned steps (6), the drying is in 45-65 DEG C of dry 20-60min；It is described mixed
Conjunction is 20r/min mixing 30-45min.
It is described to be mixed into three-dimensional hybrid in above-mentioned steps (6) according to currently preferred, select three-dimensional motion mixer.
The beneficial effects of the invention are as follows：
1, dietary composition prepared by the present invention is suitable for the nutrient imbalance caused by anaphylactoid purpura, the people of metabolic disorder
Group, this dietary composition are mixed using nutrition-allocated proportion, while ensureing sufficient diet energy, alleviation electrolyte imbalance, science tune
Intestinal Mucosal Injury in Patients Undergoing flora is saved, function of intestinal canal is improved, plays maintenance intestinal health, improves immunity of organisms.
2, dietary composition prepared by the present invention allocates other nutritional ingredients scientifically on the basis of food fibre powder,
Such as albumen powder, plant fat powder, vitamin and mineral etc., nutritional ingredient synergistic effect, comprehensive guarantee anaphylactoid purpura
Demand of the body to nutritional ingredient and energy.
3, the dietary composition selection rice starch that prepared by the present invention makees raw material, improves reconstituting for diet dietary composition
Property, the lamination after reconstituting not only is solved, but also improve mouthfeel.
4, the present invention is mainly effectively matched using Poria cocos powder, licorice powder, oligofructose, can play Reduce allergy purpura
Effect.
5, the present invention makes raw material mix when preparing edible fiber products by the way of mixing stage by stage and three-dimensional hybrid
More fully, uniform, and sufficient raw, simple production process, it is suitble to large-scale production.
Description of the drawings
Fig. 1 is the principal component analysis figure of patients before and after intervention intestinal microflora abundance.
Specific implementation mode
Principles and features of the present invention are described with reference to embodiments, illustrated embodiment is served only for explaining invention,
This is non-for limiting the scope of the present invention.
Raw material according to the present invention is ordinary commercial products.
Embodiment 1
Present embodiments provide a kind of dietary composition of Reduce allergy purpura disease, the dietary composition mainly by with
Lower parts by weight (unit：Kilogram) raw material be prepared：19 parts of rice starch, 5 parts of licorice powder, 3 parts of xylo-oligosaccharide, Poria cocos powder 3
Part, 4 parts of linseed meal, strange 6 parts of Asia seed powder (Omega-3 unsaturated fatty acid contents are not less than 18% in strange Asia seed powder), whey
5 parts of albumen powder, 4 parts of casoid flour, 0.004 part of vitamin A, 0.0035 part of vitamin D, 0.072 part of vitamin E, vitamin K1
0.0002 part, 0.0045 part of vitamin B, 0.6 part of vitamin C, 0.03 part of niacin, 0.0057 part of folic acid, 0.042 part of pantothenic acid,
0.0002 part of biotin, 0.05 part of sodium, 0.05 part of potassium, 0.03 part of copper, 0.093 part of magnesium, 0.057 part of iron, 0.03 part of zinc, manganese
0.045 part, 0.3 part of calcium, 0.04 part of phosphorus, 0.0004 part of iodine, 0.01 part of chlorine, 0.0002 part of selenium, 1 part of sodium alginate stabiliser.
The preparation method of the dietary composition is as follows：
(1) vitamin and mineral is proportionally mixed using high evenness mixing apparatus with stabilizer, obtains first
Mixture；
(2) it weighs and is mixed with the first mixture with the rice starch of the first mixture equivalent, obtain the second mixture；
(3) it weighs and continues to mix with the second mixture with the rice starch of the second mixture equivalent, obtain third mixture；
(4) remaining rice starch is mixed with third mixture, obtains the 4th mixture；
(5) it after being sufficiently mixed plant fat powder, is mixed with the 4th mixture, obtains the 5th mixture；
(6) by remaining component and the dry 60min of 60 DEG C of the 5th mixture, select three-dimensional motion mixer, 20r/min three-dimensional
45min is mixed, sterilization, granulation obtain the dietary composition with Reduce allergy purpura disease.
Embodiment 2
Present embodiments provide a kind of dietary composition of Reduce allergy purpura disease, the dietary composition mainly by with
The raw material of lower parts by weight is prepared：20 parts of rice starch, 6 parts of licorice powder, 4 parts of xylo-oligosaccharide, 4 parts of Poria cocos powder, linseed meal 5
Part, strange 5 parts of Asia seed powder (Omega-3 unsaturated fatty acid contents are not less than 18% in strange Asia seed powder), 5 parts of PURE WHEY, junket
5 parts of albumen powder, 0.005 part of vitamin A, 0.0061 part of vitamin D, 0.2 part of vitamin E, 0.00034 part of vitamin K1, dimension
Raw 0.017 part of element B, 0.6 part of vitamin C, 0.033 part of niacin, 0.0059 part of folic acid, 0.06 part of pantothenic acid, biotin 0.0003
Part, 0.1 part of sodium, 0.1 part of potassium, 0.06 part of copper, 0.096 part of magnesium, 0.062 part of iron, 0.05 part of zinc, 0.06 part of manganese, 0.5 part of calcium, phosphorus
0.2 part, 0.00065 part of iodine, 0.02 part of chlorine, 1 part of 0.0003 part of selenium, sodium alginate and maltodextrin stabilizer, the two weight ratio
It is 1.5:1.
The preparation method of the dietary composition is as follows：
(1) vitamin and mineral is proportionally mixed using high evenness mixing apparatus with stabilizer, obtains first
Mixture；
(2) it weighs and is mixed with the first mixture with the rice starch of the first mixture equivalent, obtain the second mixture；
(3) it weighs and continues to mix with the second mixture with the rice starch of the second mixture equivalent, obtain third mixture；
(4) remaining rice starch is mixed with third mixture, obtains the 4th mixture；
(5) it after being sufficiently mixed plant fat powder, is mixed with the 4th mixture, obtains the 5th mixture；
(6) by remaining component and the dry 50min of 65 DEG C of the 5th mixture, select three-dimensional motion mixer, 20r/min three-dimensional
35min is mixed, sterilization, granulation obtain the dietary composition with Reduce allergy purpura disease.
Experimental example 1
Clinical observation experiment：
Selection amounts to the diagnostic criteria that 30 patients meet anaphylactoid purpura, wherein 18 people of male, 12 people of women, age
4-15 Sui, clinical manifestation is mainly 1) blood routine：Eosinophil increases, and 2) erythrocyte sedimentation rate：Most of patients erythrocyte sedimentation rate is speeded；3) anti-O：
Increase；4) serum immune globulin：Serum IgA increases；5) blood urea nitrogen/creatinine：Increase；6) feces occult blood：It is positive；7) blood capillary
Pipe brittleness test：It is positive；8) first visit symptom：Abdominal pain, arthralgia, skin redness spot.
Intervening improves criterion：1) blood routine：Eosinophil Testing index is normal；2) erythrocyte sedimentation rate：Erythrocyte sedimentation rate is normal；3)
Anti- O：Normally；4) serum immune globulin：Serum IgA index is normal；5) blood urea nitrogen and creatinine：Index is normal；6) stool is latent
Blood：Female；7) capillary fragility test：It is negative；8) first visit symptom：Abdominal pain, arthralgia etc. improve or disappear.Wherein 3 and
The above symptom has improvement, has both regarded as improving effective.
Instructions of taking：The dietary composition that the oral present invention reconstitutes, 1 time 220ml 3 times a day takes before the meal, continuous to take
With 14 days.It is as shown in table 1 to take front and back clinical observation experiment data.
Meanwhile 1 day before and after the dietary composition for continuously taking the preparation of embodiment 1, each patient's excrement about 0.5g is taken, it carries out
16S RNA intestinal flora detection and analysises, Microflora are indicated with abundance.Data analysis is carried out with flora abundance, as a result such as Fig. 1
It is shown.
As shown in Table 1, the invention dietary composition patients before and after intervention, clinical indices have significant change, improve according to intervening
Criterion is analyzed, and after being intervened using the dietary composition, clinical manifestation takes an evident turn for the better 30 samples.Meanwhile by
Fig. 1 it is found that rectangular representative intervene before, circle represent intervene after, PCoA principal coordinate analysis show patients with anaphylactoid purpura intervene before
Rear intestinal microorganism has differences (P < 0.05).Flora imbalance before 30 clinical samples are intervened to sum up is analyzed, meals are applied after intervention
Food composition is effectively improved or adjusts the composition of patients with anaphylactoid purpura intestinal flora, and improves clinical setting, shows the diet
Composition plays the effect of Reduce allergy purpura disease.
But the invention is not limited to the embodiment, and those skilled in the art are without prejudice to spirit of that invention
With various equivalent variations, replacement, improvement can be also made under the premise of principle, these equivalent variations, replacement, improvement are all contained in this
Apply in claim limited range.
Claims (9)
1. a kind of dietary composition of Reduce allergy purpura disease, which is characterized in that by weight, including rice starch
16-25 parts, 10-14 parts of food fibre powder, 9-16 parts of plant fat powder, 8-13 parts of albumen powder, 1-7 parts of vitamin and mineral,
1-2 parts of stabilizer；
Wherein, the food fibre powder is by licorice powder, xylo-oligosaccharide, Poria cocos powder by weight (1-2)：(0.75-1.4)：1
Composition；It is (0.3-1.5) by weight that the plant fat powder, which is by linseed meal and Qi Ya seeds powder,：1 composition；The albumen
Powder is the mixing of PURE WHEY or casoid flour or its arbitrary weight ratio.
2. dietary composition as described in claim 1, which is characterized in that by weight, including 18-23 parts of rice starch,
11-14 parts of food fibre powder, 9-13 parts of plant fat powder, 9-11 parts of albumen powder, 1-4 parts of vitamin and mineral, stabilizer 1-2
Part.
3. dietary composition as claimed in claim 1 or 2, which is characterized in that the food fibre powder is by licorice powder, low
Xylan, Poria cocos powder are formed by weight for 1.5 ﹕, 1.2 ﹕ 1.
4. dietary composition as claimed in claim 1 or 2, which is characterized in that the plant fat powder is by linseed meal
It is formed by weight for (0.7-1.3) ﹕ 1 with strange sub- seed powder, wherein Omega-3 unsaturated fatty acid contents in the strange sub- seed powder
Not less than 18%.
5. dietary composition as claimed in claim 1 or 2, which is characterized in that the albumen powder is by lactalbumin and junket egg
White is (0.9-1.4) by weight：1 composition.
6. dietary composition as claimed in claim 1 or 2, which is characterized in that the vitamin and mineral, by weight
Meter is given birth to by 0.0033-0.0058 parts of vitamin A, 0.0021-0.0066 parts of vitamin D, 0.066-0.3 parts of vitamin E, dimension
Plain K1 0.00018-0.00044 parts, 0.0037-0.026 parts of vitamin B, 0.49-0.78 parts of vitamin C, niacin 0.015-
0.046 part, 0.0041-0.0059 parts of folic acid, 0.038-0.076 parts of pantothenic acid, 0.00015-0.00038 parts of biotin, sodium 0.05-
0.52 part, 0.05-0.52 parts of potassium, 0.011-0.063 parts of copper, 0.083-0.097 parts of magnesium, 0.032-0.085 parts of iron, zinc 0.014-
0.059 part, 0.041-0.062 parts of manganese, 0.2-0.56 parts of calcium, 0.011-0.85 parts of phosphorus, 0.0003-0.0008 parts of iodine, chlorine 0.01-
0.0002-0.0004 parts of 0.08 part, selenium compositions.
7. dietary composition as claimed in claim 1 or 2, which is characterized in that the stabilizer is that sodium alginate or malt are pasted
The mixing of essence or its arbitrary weight ratio.
8. a kind of preparation method of the dietary composition of Reduce allergy purpura disease as claimed in claim 1 or 2, feature
It is, includes the following steps：
(1) vitamin and mineral is proportionally mixed with stabilizer, obtains the first mixture；
(2) it weighs and is mixed with the first mixture with the rice starch of the first mixture equivalent, obtain the second mixture；
(3) it weighs and continues to mix with the second mixture with the rice starch of the second mixture equivalent, obtain third mixture；
(4) remaining rice starch is mixed with third mixture, obtains the 4th mixture；
(5) it after being sufficiently mixed plant fat powder, is mixed with the 4th mixture, obtains the 5th mixture；
(6) remaining component is mixed after drying with the 5th mixture, sterilizes, pelletizes, the anaphylactoid purpura that is eased disease
Dietary composition.
9. preparation method as claimed in claim 8, which is characterized in that in step (6), the drying is in 45-65 DEG C of drying
20-60min；The mixing is 20r/min mixing 30-45min；Wherein, described to be mixed into three-dimensional hybrid.
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| JPH09169659A (en) * | 1995-12-21 | 1997-06-30 | Nissei Marine Kogyo Kk | Composition having antinuclear antibody decreasing action and rheumatoid factor decreasing action |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09169659A (en) * | 1995-12-21 | 1997-06-30 | Nissei Marine Kogyo Kk | Composition having antinuclear antibody decreasing action and rheumatoid factor decreasing action |
| CN104839695A (en) * | 2015-04-23 | 2015-08-19 | 劲膳美生物科技股份有限公司 | Non-complete nutritional formula food for inflammatory bowel disease |
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Application publication date: 20181113 |