CN105995996A - Preparation method of oral liquid for preventing constipation in pregnancy - Google Patents
Preparation method of oral liquid for preventing constipation in pregnancy Download PDFInfo
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- CN105995996A CN105995996A CN201610367635.4A CN201610367635A CN105995996A CN 105995996 A CN105995996 A CN 105995996A CN 201610367635 A CN201610367635 A CN 201610367635A CN 105995996 A CN105995996 A CN 105995996A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/52—Juglandaceae (Walnut family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/169—Plantarum
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/529—Infantis
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Abstract
The invention discloses a preparation method of oral liquid for preventing constipation in pregnancy. The preparation method comprises the following steps of taking carrots, thoroughly cleaning the taken carrots, adding warm boiled water which is 2-3 times of the weight of the carrots, and squeezing juice at low temperature; taking spinach, celery and sweet potato leaves, adding water with amount being 2-5 times of the total amount of the spinach, the celery and the sweet potato leaves, performing boiling over, and lowering the temperature for standby application; taking sweet potatoes and apples, performing peeling, and performing grinding to obtain mashed sweet potato and mashed apples for standby application; taking walnuts, and crushing the taken walnuts for standby application; putting the prepared materials to a fermentation tank, performing uniform stirring, and performing pasteurization; adding bifidobacterium infantis and lactobacillus plantarum to the fermentation tank, and performing sealed fermentation; after fermentation, taking a supernatant; squeezing juice from fermentation substrates; and mixing the squeezed juice with the supernatant so as to obtain mixed liquor, and then adding honey, fructo-oligosaccharide, sodium sorbate, and B-group vitamin to the mixed liquor. The raw materials adopted by the preparation method are safe food materials suitable for women in a pregnancy period, and after being specially processed, the materials are rich in nutrient components which are beneficial for intestinal tract peristalsis and adjustment of intestinal flora, and are easy to absorb and utilize, and the effect of preventing constipation is good.
Description
Technical field
The present invention relates to technical field of health care food, be specifically related to a kind of constipation in pregnancy of preventing
The preparation method of oral liquid.
Background technology
Trimester of pregnancy increases due to corpus luteum, Progesterone Secretion, and colonic activity is suppressed.China passes
The system theory of nourishing causes maternal nutritional to take in change, high protein, cellulose diet higher fatty acid, low;
Movable minimizing, trimester of pregnancy defecation the most freely makes anemia of pregnant woman reduce defecation consciously.After pregnant 6 months
Uterus increases, compressing intestinal tube and pelvic blood vessels, all may result in constipation occur or increase the weight of original just
Secret.
Pregnancy period constipation class of medications is limited, and conventional irritant laxative can cause stomachache even son
Palace is shunk, and emollient laxative then may interfere with the parent absorption to fatsoluble vitamin, causes new life
Youngster occurs the disease such as Hypoprothrombinemia relevant to vitamin deficiency hemorrhage.
China's traditional medicine have " integration of edible and medicinal herbs ", the theory of " medicine is controlled not as dietetic therapy ".Food
Treatment is diet, is again medicine, has two-way feature, can reach medical treatment by the approach of diet
Purpose.For the needs of the women fetus to be taken into account of constipation in pregnancy, to preventing miscarriage, anemia of pregnant woman prevents and treats just
Secret most preferably nurse one's health from diet.But the diet of routine is difficult to reasonably combined, operable
Property strong, and be not easy to be fully absorbed utilization.Application No. 201510735157.3
Chinese invention patent application discloses a kind of full nutritional formulas of pregnant woman constipation, this food former
Material have employed substantial amounts of Chinese medicine material, as Radix Adenophorae (Radix Glehniae), the Radix Astragali, Radix Angelicae Sinensis, Semen Platycladi, Rhizoma Chuanxiong,
Huang, the Radix Paeoniae Alba, Radix Et Rhizoma Rhei, the Rhizoma Atractylodis Macrocephalae etc., for pregnancy women and non-real safety food.
Summary of the invention
It is an object of the invention to overcome the defect of above-mentioned prior art, it is provided that a kind of prevention gestation
The preparation method of the oral liquid of phase constipation, the raw material that this oral liquid is used is and is suitable for gestation
The safe food materials of phase women, after special processing, containing abundant be of value to intestinal peristalsis promoting,
The nutritional labeling of regulating intestinal canal flora, is readily absorbed by utilizing, and Constipation is effective.
For achieving the above object, the present invention adopts the following technical scheme that
The preparation method of a kind of oral liquid preventing constipation in pregnancy, it is characterised in that include following
Step:
(1) taking Radix Dauci Sativae to clean, the warm water low temperature adding 2-3 times of Radix Dauci Sativae weight is squeezed the juice;
(2) take Herba Spinaciae, Herba Apii graveolentis, Folium Ipomoeae add 2-5 times of decocting in water open, lower the temperature standby;
(3) take Radix Pachyrhizi Erosi and apple peel, grind to form mud standby;
(4) take Semen Juglandis and pulverize standby;
(5) material step (1) to (4) prepared puts in fermentation tank, stirs, bar
Family name sterilizes;
(6) in fermentation tank, bifidobacteria infantis and Lactobacillus plantarum, sealing and fermenting are added;
(7) supernatant is taken after fermentation;
(8) fermentation substrate is pressed juice;
(9) pressure juice and supernatant mixing, then toward mixed liquor adds Mel, oligofructose,
Sodium sorbate, vitamin A, vitamin B1, vitamin B2, vitamin B6, dimension are raw
Element B12;
(10) ultrasound wave is mixed.
Preferably, step (1) low temperature is squeezed the juice is to carry out at 20-30 DEG C.
Preferably, the addition of bifidobacteria infantis is step (1) to (4) all material weight
The 5-12% of amount, the addition of Lactobacillus plantarum is step (1) to (4) all material weight
7-10%.
Preferably, the temperature of pasteurize is 70-75 DEG C, and the time is 30-40min.
Preferably, the temperature of sealing and fermenting is 30-40 DEG C, and the time is 5-10 days.
Preferably, the addition of Mel is the 0.5-3% of mixed liquor weight, adding of oligofructose
Entering the 0.1-1% that amount is mixed liquor weight, the addition of vitamin A is mixed liquor weight
0.01-0.1%, the addition of vitamin B1 is the 0.01-0.1% of mixed liquor weight, vitamin
The addition of B2 is the 0.01-0.1% of mixed liquor weight, and the addition of vitamin B6 is mixing
The 0.01-0.1% of liquid weight, the addition of vitamin B12 is the 0.01-0.1% of mixed liquor weight.
Preferably, sodium sorbate addition is the 0.35-1.5% of mixed liquor total amount.
Preferably, in raw material, every 1000g Radix Dauci Sativae uses 100-200g Herba Spinaciae, 100-200g
Herba Apii graveolentis, 100-200g Folium Ipomoeae, 100-200g Radix Pachyrhizi Erosi, 50-100g Fructus Mali pumilae, 50-100g core
Fructus Persicae.
Compared with prior art, the invention has the beneficial effects as follows:
1, the raw material of the present invention is safe food materials, to pregnancy women and fetal well-being without
Side effect, food materials are through selected collocation, after bifidobacteria infantis and Lactobacillus plantarum ferment,
Give full play to food materials alleviate the effective ingredient of constipation, help lend some impetus to intestinal peristalsis promoting, regulation
Intestinal microbial population, softer stool, it is simultaneously introduced Mel, oligofructose, vitamin A, dimension life
The nutrients such as element B1, vitamin B2, B6, B12, promote intestinal peristalsis promoting, in advance further
Prevent, alleviate constipation.
2, the present invention is prone to edible, workable.
Detailed description of the invention
Below, by detailed description of the invention, the present invention is described further.
A kind of preparation method of the oral liquid preventing constipation in pregnancy, it comprises the following steps:
(1) take Radix Dauci Sativae to clean, add the warm water of 2-3 times of Radix Dauci Sativae weight 20-30 DEG C of temperature
Squeeze the juice under degree;
(2) take Herba Spinaciae, Herba Apii graveolentis, Folium Ipomoeae add 2-5 times of decocting in water open, lower the temperature standby;
(3) take Radix Pachyrhizi Erosi and apple peel, grind to form mud standby;
(4) take Semen Juglandis and pulverize standby;
(5) material step (1) to (4) prepared puts in fermentation tank, stirs, bar
Family name sterilizes, and the temperature of pasteurize is 70-75 DEG C, and the time is 30-40min;
(6) in fermentation tank, add bifidobacteria infantis and Lactobacillus plantarum, sealing and fermenting, seal
The temperature of fermentation is 30-40 DEG C, and the time is 5-10 days;The addition of bifidobacteria infantis
Amount is the 5-12% of step (1) to (4) all material weight (aqueous), plant breast
The addition of bacillus is the 7-10% of step (1) to (4) all material weight (aqueous).
(7) supernatant is taken after fermentation;
(8) fermentation substrate is pressed juice;
(9) pressure juice and supernatant mixing, then toward mixed liquor adds Mel, oligofructose,
Sodium sorbate, vitamin A, vitamin B1, vitamin B2, vitamin B6, dimension are raw
Element B12;
(10) ultrasound wave is mixed;
(11) bottling.
The addition of each raw material is as follows:
Clinical trial
(1) method: matched group drinks boiled water, reasonably combined diet every day, trains after getting up every day
Defecation;Test group noon every day and evening drink the oral liquid of the 20mL present invention after meal, other
Situation is identical with matched group.
(2) observation index: the defecation situation of two groups and untoward reaction after observing 2 weeks.
(3) criterion of therapeutical effect: effective: natural defecation, defecation character and frequency are normal;Effective: row
Just difficulty but frequency and character are normal;Invalid: difficult defecation, frequency and character are abnormal.No
Good reaction: seen whether that diarrhoea or other abnormal conditions occur, if there is abnormal conditions
Stop test immediately.
(4) result
For a person skilled in the art, can technical scheme as described above and structure
Think, make other various corresponding changes and deformation, and all these changes and deformation
Within all should belonging to the protection domain of the claims in the present invention.
Claims (8)
1. the preparation method of the oral liquid preventing constipation in pregnancy, it is characterised in that include following
Step:
(1) taking Radix Dauci Sativae to clean, the warm water low temperature adding 2-3 times of Radix Dauci Sativae weight is squeezed the juice;
(2) take Herba Spinaciae, Herba Apii graveolentis, Folium Ipomoeae add 2-5 times of decocting in water open, lower the temperature standby;
(3) take Radix Pachyrhizi Erosi and apple peel, grind to form mud standby;
(4) take Semen Juglandis and pulverize standby;
(5) material step (1) to (4) prepared puts in fermentation tank, stirs, bar
Family name sterilizes;
(6) in fermentation tank, bifidobacteria infantis and Lactobacillus plantarum, sealing and fermenting are added;
(7) supernatant is taken after fermentation;
(8) fermentation substrate is pressed juice;
(9) pressure juice and supernatant mixing, then toward mixed liquor adds Mel, oligofructose,
Sodium sorbate, vitamin A, vitamin B1, vitamin B2, vitamin B6, dimension are raw
Element B12;
(10) ultrasound wave is mixed.
2. the preparation method of the oral liquid of prevention constipation in pregnancy as claimed in claim 1, it is special
Levy and be: it is to carry out at 20-30 DEG C that step (1) low temperature is squeezed the juice.
3. the preparation method of the oral liquid of prevention constipation in pregnancy as claimed in claim 1, it is special
Levy and be: the addition of bifidobacteria infantis is step (1) to (4) all material weight
The 5-12% of amount, the addition of Lactobacillus plantarum is step (1) to (4) all material
The 7-10% of weight.
4. the preparation method of the oral liquid of prevention constipation in pregnancy as claimed in claim 1, it is special
Levying and be: the temperature of pasteurize is 70-75 DEG C, the time is 30-40min.
5. the preparation method of the oral liquid of prevention constipation in pregnancy as claimed in claim 1, it is special
Levying and be: the temperature of sealing and fermenting is 30-40 DEG C, the time is 5-10 days.
6. the preparation method of the oral liquid of prevention constipation in pregnancy as claimed in claim 1, it is special
Levy and be: the addition of Mel is the 0.5-3% of mixed liquor weight, the addition of oligofructose
Amount is the 0.1-1% of mixed liquor weight, and the addition of vitamin A is mixed liquor weight
0.01-0.1%, the addition of vitamin B1 is the 0.01-0.1% of mixed liquor weight, dimension
The 0.01-0.1% that addition is mixed liquor weight of raw element B2, the addition of B6 is mixing
The addition of the 0.01-0.1% of liquid weight, B12 is the 0.01-0.1% of mixed liquor weight.
7. the preparation method of the oral liquid of prevention constipation in pregnancy as claimed in claim 1, it is special
Levying and be, sodium sorbate addition is the 0.35-1.5% of mixed liquor total amount.
8. the preparation method of the oral liquid of prevention constipation in pregnancy as claimed in claim 1, it is special
Levy and be: raw material comprises Radix Dauci Sativae 1000g, Herba Spinaciae 100-200g, Herba Apii graveolentis 100-200
Gram, Folium Ipomoeae 100-200g, Radix Pachyrhizi Erosi 100-200g, Fructus Mali pumilae 50-100g, Semen Juglandis
50-100g。
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Cited By (2)
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CN106723028A (en) * | 2016-12-09 | 2017-05-31 | 张桂菊 | A kind of health care oral liquid |
WO2020120394A1 (en) * | 2018-12-11 | 2020-06-18 | Dsm Ip Assets B.V. | Use of riboflavin to benefit bowel health |
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CN104605277A (en) * | 2013-11-05 | 2015-05-13 | 熊涛 | Functional probiotic fermented fruit and vegetable powder preparation method |
CN105124356A (en) * | 2015-10-27 | 2015-12-09 | 江西美庐乳业集团有限公司 | Nutritional package for treating anemia, astriction and lumbus and leg pains of pregnant and lying-in women |
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CN101077209A (en) * | 2006-05-22 | 2007-11-28 | 陕西天宝大豆食品技术研究所 | Walnut lactic acid bacteria beverage and preparing process thereof |
CN104605277A (en) * | 2013-11-05 | 2015-05-13 | 熊涛 | Functional probiotic fermented fruit and vegetable powder preparation method |
CN105124356A (en) * | 2015-10-27 | 2015-12-09 | 江西美庐乳业集团有限公司 | Nutritional package for treating anemia, astriction and lumbus and leg pains of pregnant and lying-in women |
Cited By (5)
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CN106723028A (en) * | 2016-12-09 | 2017-05-31 | 张桂菊 | A kind of health care oral liquid |
WO2020120394A1 (en) * | 2018-12-11 | 2020-06-18 | Dsm Ip Assets B.V. | Use of riboflavin to benefit bowel health |
CN113194749A (en) * | 2018-12-11 | 2021-07-30 | 帝斯曼知识产权资产管理有限公司 | Use of riboflavin for benefiting intestinal health |
JP2022510939A (en) * | 2018-12-11 | 2022-01-28 | ディーエスエム アイピー アセッツ ビー.ブイ. | Use of riboflavin to benefit intestinal health |
JP7638210B2 (en) | 2018-12-11 | 2025-03-03 | ディーエスエム アイピー アセッツ ビー.ブイ. | Using Riboflavin to Benefit Gut Health |
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