CN108721607A - A kind of collagen-rich anti-senility oral liquid and preparation method thereof - Google Patents
A kind of collagen-rich anti-senility oral liquid and preparation method thereof Download PDFInfo
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- CN108721607A CN108721607A CN201710276096.8A CN201710276096A CN108721607A CN 108721607 A CN108721607 A CN 108721607A CN 201710276096 A CN201710276096 A CN 201710276096A CN 108721607 A CN108721607 A CN 108721607A
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Classifications
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Abstract
The invention belongs to health product technology field, it is related to a kind of collagen-rich anti-senility oral liquid and preparation method thereof.The oral solution is made of following component in parts by weight：20~40 parts of collagens, 5~10 portions of Semen sesami nigrums, 5~10 portions of trilliaceae, 2~5 parts of rhodiola roots, 2~5 portions of Radix Glycyrrhizaes, 3~8 parts of honey, 3~8 parts of beta-cyclodextrins, 5~10 parts of yellow rice wine and 30~50 parts of purified waters, skin ageing symptoms can be effectively antagonized, and preparation method is simple and easy to do, it is suitable for exploitation into corresponding health products, great market prospects.
Description
Technical field
The invention belongs to health product technology fields, are related to antisenescence health product, more particularly to a kind of collagen-rich
Anti-senility oral liquid and preparation method thereof.
Background technology
Skin is maximum organ in human body, and oxidation, dry and radiation are highly prone to because directly being contacted with external environment
Etc. external factor stimulation.Meanwhile and because of the influence of the internal factors such as age, diet and living habit, leading to skin function
Decline and hereditary grotesque, to make skin be more prone to aging.Since skin is in the surface of human body, anti-aging product at
For one of the product of vast female consumer active demand.
Collagen (collagen) is the main component in skin, and moisture-retention function of skin can be improved, and adjusts skin surface
Grease balances, and promotes the tension and elasticity of deep skin fibr tissue.Studies have shown that under normal circumstances, human collagen albumen
Content can be gradually lost in.By taking skin as an example, with age or the influence of other external factor, skin can follow the string, and
And thinning, aging；Meanwhile the loss of collagen can lead to fibrous fracture, lipoatrophia, sweat gland and the smegma of corium
It reduces, a series of aging phenomena such as color spot, wrinkle occurs.Therefore, either in terms of medical angle, or in terms of health care angle,
Appropriate replenishing collagen is conducive to keep the health status of human skin, effectively antagonizes aging.
In recent years, in order to find the effective ways for preventing and alleviating wrinkle of skin, researcher grind extensively
Study carefully and illustrate the important function of collagen.However, the existing cosmetics comprising collagen are applied to skin table mostly
On face, the collagen of high molecular weight is difficult to Transdermal absorption, therefore can not improve the appearance of skin.
Since external application can not obtain desired effect, then for oral administration be then likely to be effective solution means.Therefore, it finds new
Anti aging effect method still attract numerous researchers.Chinese medicine is with its unique advantage, in grinding for anti aging effect field
Study carefully work extensively to be carried out, but pass through retrieval, there is no produced about the anti-aging that collagen and Chinese medicine is used in combination at present
The document report of product.
Invention content
The purpose of the present invention is to provide a kind of anti-senility oral liquid that collagen and Chinese medicine is used in combination and its preparations
Method, to make up blank in the prior art.
To achieve the goals above, the present invention adopts the following technical scheme that：
A kind of collagen-rich anti-senility oral liquid, is made of following component in parts by weight：20~40 parts
Collagen, 5~10 portions of Semen sesami nigrums, 5~10 portions of trilliaceae, 2~5 parts of rhodiola roots, 2~5 portions of Radix Glycyrrhizaes, 3~8 parts of honey, 3
~8 parts of beta-cyclodextrins, 5~10 parts of yellow rice wine, 30~50 parts of purified waters, preferably 30 parts of collagens, 7 portions of Semen sesami nigrums, 7 parts prolong
Age grass, 3 parts of rhodiola roots, 3 portions of Radix Glycyrrhizaes, 6 parts of honey, 6 parts of beta-cyclodextrins, 8 parts of yellow rice wine, 40 parts of purified waters.
In above-mentioned oral solution, the source of the collagen is arbitrary in black carp, grass carp, silver carp and bighead
One kind, preparation method the appointing in hot water extraction method, extraction, salt extraction method and enzyme extraction method of the collagen
Meaning is a kind of, and the molecular weight of the collagen is 2000~3000Da.
In above-mentioned oral solution, the Semen sesami nigrum is Pedaliaceae flax platymiscium sesame (Sesamum indicum DC)
Mature seed, China is generally cultivated various regions.Semen sesami nigrum is mild-natured, sweet in flavor, returns liver and kidney channel, for help essence and blood, moisturize laxation.It is black
Lignanoids (such as sesamin, sesamol, sesamolin) and unsaturated fatty acids (such as linoleic acid, flax are rich in sesame
Acid, arachidonic acid etc.) ingredient.
In above-mentioned oral solution, the trilliaceae is Liliaceae Trillium plant trilliaceae (Trillium
Tschonoskii Maxim.) rhizome, main product is in provinces and regions such as Tibet, Yunnan, Sichuan, Shaanxi, Gansu.Trilliaceae is warm-natured, taste
Sweet, micro-pungent, converge to heart and liver channels, for calm, tranquilizing the mind, promoting blood circulation, removing toxic substances.In trilliaceae rich in steroid saponin (such as cryptogenin,
Trillarin) ingredient.
In above-mentioned oral solution, the rhodiola root is Crassulaceae Rhodida plant rhodiola root (Rhodiola rosea
L. herb), main product is in provinces and regions such as Heilungkiang, Jilin, Tibet, Yunnan, Ningxia.Rhodiola root is cold in nature, sweet in flavor, puckery, distributed in lung channel, uses
In tonifying Qi clearing lung-heat, intelligence development nourishing heart, controlling of bleeding with astringents, eliminating stasis to subdue swelling.Tyrosol and its glycoside, flavonoids (such as kaempferia galanga are rich in rhodiola root
Phenol), Coumarins (such as umbelliferone) ingredient.
In above-mentioned oral solution, the Radix Glycyrrhizae is pulse family glycyrrhiza genus Radix Glycyrrhizae (Glycyrrhiza uralensis
Fisch root), wild varieties are distributed mainly on Xinjiang, the Inner Mongol, Ningxia, Gansu, Shanxi, and artificial growth kind main product is in new
Boundary, the Inner Mongol, the Hexi Corridor in Gansu and countries of Ningxia Hui Autonomous Region area.Radix Glycyrrhizae is mild-natured, sweet in flavor, the thoughts of returning home, lung, spleen, stomach, for mending
Spleen QI invigorating moistens the lung and relieve the cough, relieving spasm to stop pain, mitigates pharmacological property.It is (such as sweet rich in triterpene saponin (such as glycyrrhizic acid) and flavonoids in Radix Glycyrrhizae
Careless element) ingredient.
In above-mentioned oral solution, the honey is Apidae Apis animal apis cerana (Apis cerana
Fabricius) or the glucide that leads in beehive of apis mellifera Linnaeus (Apis mellifera ligustica Spinola),
China various regions produce, and main product is in Hubei, Sichuan, Yunnan, Henan and other places.Honey is mild-natured, sweet in flavor, returns spleen, lung, large intestine channel,
For bowl spares emergency, moisten the lung and relieve the cough, laxation defaecation.In honey rich in carbohydrate (such as glucose, fructose, sucrose, maltose) and
Amino acids (such as proline, lysine, aspartic acid) ingredient.
In above-mentioned oral solution, the beta-cyclodextrin is cyclized the product generated for starch through acidolysis, can be with a variety of chemical combination
Object forms inclusion complex, makes its stabilizations, solubilising, sustained release, emulsification, anti-oxidant, antidecomposition, heat preservation, moisture-proof, and have masking different
The effects that taste is a kind of novel molecule lapping.
In above-mentioned oral solution, the yellow rice wine be with rice, milled glutinous broomcorn millet, maize etc. for primary raw material, through adding the sugar such as song, yeast
Change fermented wine made of leavening brewing.Yellow rice wine is warm-natured, sweet in flavor, bitter, pungent, toxic, the thoughts of returning home, liver, lung, stomach, has promoting blood circulation logical
The effect of network, expelling wind and clearing away cold, for chill numbness pain, Spasm of the tendons, the obstruction of qi in the chest, trusted subordinate's crymodynia etc..Yellow rice wine belongs to low brewed wine,
In contain 12%~18% (v/v) ethyl alcohol, and containing maltose, glucose and succinic acid, lactic acid, amino acid, esters
With the ingredients such as aldehydes.
In above-mentioned oral solution, the purified water be by drinking water through the way of distillation, ion-exchange, hyperfiltration or other
Water for pharmaceutical purposes made from suitable method.
The preparation method of above-mentioned oral solution comprising following steps：
1) collagen of formula ratio, Semen sesami nigrum, trilliaceae, rhodiola root and Radix Glycyrrhizae are crushed respectively, crosses 60~80
Mesh sieves, and obtains collagen powder, black sesame powder, trilliaceae powder, rhodiola root powder and licorice powder；
2) by the mixture of the black sesame powder obtained in step 1), trilliaceae powder, rhodiola root powder and licorice powder with 4~8 times
The alcohol reflux of volume extracts 10~20 hours, the dregs of a decoction is filtered out after extraction, filtrate is concentrated into no alcohol taste, obtains medicinal extract；
3) yellow rice wine of formula ratio is heated to 40~50 DEG C, dilution step 2) in obtained medicinal extract, add formula ratio
The collagen powder obtained in honey, beta-cyclodextrin and purified water and step 1), carries out low temperature sterilization after mixing
And sterile filling, obtain collagen-rich anti-senility oral liquid.
In a preferred embodiment, Semen sesami nigrum described in step 1), trilliaceae, rhodiola root and Radix Glycyrrhizae are drying
Product.
In a preferred embodiment, the mesh number sieved described in step 1) is 60 mesh.
In a preferred embodiment, collagen powder described in step 2), black sesame powder, trilliaceae powder,
The alcohol reflux of 6 times of volumes of the mixture of rhodiola root powder and licorice powder extracts 15 hours.
In a preferred embodiment, the heating temperature of yellow rice wine described in step 3) is 40 DEG C.
The application method of above-mentioned oral solution is as follows：For the patient for skin ageing symptoms occur, daily after getting up
And 5~10mL of oral solution is respectively taken before sleep, it is equipped with warm water delivery service, is used continuously 5~10 weeks, you can related disease is effectively relieved
Shape.
Compared with prior art, there are following advantages using the present invention of above-mentioned technical proposal：
1) lack in the prior art and declined using collagen as main component and the anti-skin that coordinates Chinese medicine to use
Old oral solution, the present invention exactly compensate for above-mentioned blank, have widened the application field of collagen；
2) it assists collagen to play anti-aging function using nourishing class Rhodiola, is aided with trilliaceae
Promoting blood circulation and detoxication acts on and the effect of the runchang detoxification of Semen sesami nigrum and honey, and by Radix Glycyrrhizae come coordinating the drug actions of a prescription, while avoiding
The sense of discomfort that the intrinsic smell of medicine ingredient is brought, improves the compliance of patient；
3) it is demonstrated experimentally that the oral solution prescription of the present invention is simple, skin ageing symptoms, and preparation method letter can be effectively antagonized
Easy row is suitable for exploitation into corresponding health products, great market prospects.
Specific implementation mode
Technical scheme of the present invention is made below in conjunction with specific embodiment further elucidated above.The following example is only used
In the explanation and illustration present invention, and should not be taken as limiting the scope of the invention.Unless otherwise stated, institute in the following example
Instrument, reagent, material for using etc. can be obtained by routine business means.
Embodiment 1- embodiments 5：The preparation of collagen-rich anti-senility oral liquid.
Collagen-rich anti-senility oral liquid is prepared according to the formula in table 1, preparation process is as follows：
(1) respectively by dry collagen (be made by enzyme extraction method by grass carp fish-skin, molecular weight is 2000~
3000Da), Semen sesami nigrum, trilliaceae, rhodiola root and Radix Glycyrrhizae crush, and cross 60 mesh sieve, obtain collagen powder, Semen sesami nigrum
Powder, trilliaceae powder, rhodiola root powder and licorice powder；
(2) by 6 times of bodies of the mixture of the black sesame powder, trilliaceae powder, rhodiola root powder and the licorice powder that are obtained in step (1)
The alcohol reflux extraction 15 of product (dosage in Examples 1 to 5 is respectively 180mL, 84mL, 114mL, 138mL and 120mL) is small
When, the dregs of a decoction are filtered out after extraction, filtrate is concentrated into no alcohol taste, obtains medicinal extract；
(3) yellow rice wine is heated to 40 DEG C, the medicinal extract obtained in dilution step (2) adds honey, beta-cyclodextrin and purifying
The collagen powder obtained in water and step (1) carries out low temperature sterilization and sterile filling, is rich in after mixing
The anti-senility oral liquid of collagen.
The prescription and dosage of 1. collagen-rich anti-senility oral liquid of table
Test example 1：The quality testing of oral solution of the present invention.
According to《GB 16740-2014 national food safety standard health foods》In detection project and detection method to reality
The oral solution applied in example 1~5 is detected, and the results are shown in Table 2.As shown in Table 2, indices are met the requirements of the standard.
The quality inspection result of 2. oral solution of table
Test example 2：The study on the stability of index components in oral solution of the present invention.
Oral solution in embodiment 5 is positioned at ambient temperature at shady and cool dry, the 1st after placement, 4,7,
10, it samples within 15 and 30 days, is calculated as 100% with the content of various active constituents in the 1st day sampling sample, measures each sub-sampling thereafter
The relative amount of middle tie element investigates storage stability of the oral solution under the drying condition of room temperature cool place whereby, and result is such as
Shown in table 3.
The storage stability result of index ingredient in 3. oral solution of table.
As shown in Table 3, in 30 days detection cycles, it is placed in chief active in the oral solution under the drying condition of room temperature cool place
The relative amount of ingredient can maintain 90% or more, show that the oral solution can be protected effectively in about 4 weeks storage times
Stay the activity of leading indicator ingredient.
Test example 3：The drug safety of oral solution of the present invention is investigated.
Content of the test：Acute toxicity test；Four genetic toxicity tests (are replied with reference to the bacterium of GB 15193.4-2014
Mutant test, with reference to the mammalian erythropoietin micronucleus test of GB 15193.5-2014, with reference to the small of GB 15193.7-2003
Mouse sperm malformation test, the Mouse Spermatogonial Cells chromosomal aberration test with reference to GB 15193.8-2014)；Rat tradition teratogenesis
Experiment；30 days feeding trials of rat.
Test result：The rats and mice LD50 of passing through mouth of two kinds of genders of oral solution pair of the present invention is all higher than 15g/kg weight, according to
Acute toxicity is classified, and belongs to practical non-poisonous material；Four genetic toxicity test results are feminine gender；Rat traditional teratogenicity test is not shown
Teratogenesis is shown；After 30 days feeding trials of rat, clinical indices, hematological indices and blood biochemical analysis index are just
Often, compared with the control group, difference is not notable for experimental group.
Test example 4：The health-care efficacy clinical test of oral solution of the present invention.
60 subjects, are women, average age 40 years old, and stochastic averagina is divided into 3 groups：Treatment group, externally applied product control
Group and blank control group.
Oral solution (the specification in embodiment 5 is used for treatment group subject：10mL/ branch), it after getting up and sleeps daily
It is preceding respectively to take 1, it is equipped with a small amount of warm water delivery service, is used continuously 8 weeks；Collagen is used for externally applied product control group subject
Shining face MASQUE APAISANT HYDRATANT (Guangzhou Qi Yu responsibilities Co., Ltd), it is each after getting up and before sleep daily to apply 1 time, while taking a small amount of temperature
Boiling water is used continuously 8 weeks；Blank control group subject only takes a small amount of warm water after getting up and before sleep daily, continuously makes
With 8 weeks.During experiment, special limitation is not made to the diet of subject, movement and using situations such as cosmetics.Test result is such as
Shown in table 4.
4. anti aging effect test result of table
The result shows that：After continuously taking oral solution of the present invention 8 weeks, compared with blank control group, treatment group is in skin
Moisture, elasticity, brightness and wrinkle etc. are improved, and subject's ratio that reflection skin integral status is optimized is high
Up to 90% (be better than externally applied product control group 60%), and no subject reflects in therapeutic process adverse reaction occur.By
This is and safe and harmless as it can be seen that oral solution of the present invention can effectively antagonize skin aging problem, is suitable for popularization and application.
Claims (10)
1. a kind of collagen-rich anti-senility oral liquid, it is characterised in that：
The oral solution is made of following component in parts by weight：20~40 parts of collagens, 5~10 parts of Semen sesami nigrums, 5
~10 portions of trilliaceae, 2~5 parts of rhodiola roots, 2~5 portions of Radix Glycyrrhizaes, 3~8 parts of honey, 3~8 parts of beta-cyclodextrins, 5~10 parts of yellow rice wine and
30~50 parts of purified waters.
2. collagen-rich anti-senility oral liquid according to claim 1, it is characterised in that：
The oral solution is made of following component in parts by weight：30 parts of collagens, 7 portions of Semen sesami nigrums, 7 parts prolong age
Grass, 3 parts of rhodiola roots, 3 portions of Radix Glycyrrhizaes, 6 parts of honey, 6 parts of beta-cyclodextrins, 8 parts of yellow rice wine and 40 parts of purified waters.
3. collagen-rich anti-senility oral liquid according to claim 1 or 2, it is characterised in that：
Any one of the source of the collagen in black carp, grass carp, silver carp and bighead.
4. collagen-rich anti-senility oral liquid according to claim 1 or 2, it is characterised in that：
The preparation method of the collagen appointing in hot water extraction method, extraction, salt extraction method and enzyme extraction method
Meaning is a kind of.
5. collagen-rich anti-senility oral liquid according to claim 1 or 2, it is characterised in that：
The molecular weight of the collagen is 2000~3000Da.
6. the preparation method of collagen-rich anti-senility oral liquid according to any one of claim 1 to 5, special
Sign is：
The preparation method includes the following steps：
1) collagen of formula ratio, Semen sesami nigrum, trilliaceae, rhodiola root and Radix Glycyrrhizae are crushed respectively, cross 60~80 mesh sieve,
Obtain collagen powder, black sesame powder, trilliaceae powder, rhodiola root powder and licorice powder；
2) by 4~8 times of volumes of the mixture of the black sesame powder obtained in step 1), trilliaceae powder, rhodiola root powder and licorice powder
Alcohol reflux extract 10~20 hours, the dregs of a decoction are filtered out after extraction, filtrate is concentrated into no alcohol taste, obtains medicinal extract；
3) yellow rice wine of formula ratio is heated to 40~50 DEG C, dilution step 2) in obtained medicinal extract, add formula ratio honey,
The collagen powder obtained in beta-cyclodextrin and purified water and step 1) carries out low temperature sterilization and sterile after mixing
It is filling, obtain collagen-rich anti-senility oral liquid.
7. preparation method according to claim 6, it is characterised in that：
Semen sesami nigrum described in step 1), trilliaceae, rhodiola root and Radix Glycyrrhizae are dry product.
8. preparation method according to claim 6, it is characterised in that：
The mesh number sieved described in step 1) is 60 mesh.
9. preparation method according to claim 6, it is characterised in that：
Collagen powder described in step 2), black sesame powder, trilliaceae powder, rhodiola root powder and licorice powder mixture with 6
The alcohol reflux of times volume extracts 15 hours.
10. preparation method according to claim 6, it is characterised in that：
The heating temperature of yellow rice wine described in step 3) is 40 DEG C.
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Application publication date: 20181102 |