CN108721520A - It is a kind of to be used to improve oral solution of immunity and preparation method thereof - Google Patents
It is a kind of to be used to improve oral solution of immunity and preparation method thereof Download PDFInfo
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- CN108721520A CN108721520A CN201710275444.XA CN201710275444A CN108721520A CN 108721520 A CN108721520 A CN 108721520A CN 201710275444 A CN201710275444 A CN 201710275444A CN 108721520 A CN108721520 A CN 108721520A
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- 238000012545 processing Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000012372 quality testing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 230000005070 ripening Effects 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 208000022925 sleep disturbance Diseases 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 150000005856 steroid saponins Chemical class 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 231100000211 teratogenicity Toxicity 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 235000004330 tyrosol Nutrition 0.000 description 1
- ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 1
- HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention belongs to health product technology fields, are related to a kind of for improving oral solution of immunity and preparation method thereof.The oral solution is made of following component in parts by weight：20~50 portions of fruits of Chinese wolfberry, 3~6 parts of sealworts, 2~5 parts of Radix Polygalaes, 1~3 part of rhodiola root, 3~6 parts of cortex acanthopanacis, 3~6 portions of smilaxs, 2~5 portions of Radix Glycyrrhizaes, 3~6 parts of yellow rice wine and 30~60 parts of purified waters, the immunity of organisms of sub-health population can be effectively improved, and preparation method is simple and easy to do, it is suitable for exploitation into corresponding health products, great market prospects.
Description
Technical field
The invention belongs to health product technology field, it is related to oral solution improved the immunity of the human body and preparation method thereof.
Background technology
Immunity is a kind of effective human body host defence mechanism, can identify and eliminate any foreign matter of external intrusion
(such as virus, bacterium) handles the own cells of aging, damage, death, denaturation, identification and processing vivo mutations cell and disease
Malicious infection cell.Body immunity is lowly easy to infected or suffers from cancer, but immunity is extraordinary also will produce deleterious consequence (such as
Cause allergic reaction, autoimmune disease etc.).When immune system normally cannot play protective effect, easily incur infection, because
It is exactly liable to illness that this hypoimmunity, which most directly shows, and because of frequent illness, has aggravated the consumption of body, therefore usual companion
Have a delicate constitution, the reduction of malnutritive, apathetic, fatigue and weak, appetite, the performances such as sleep disturbance.Can if things go on like this it cause
Body and intellectual development are bad, also easily induce major disease.
103120717 A of CN disclose a kind of traditional Chinese medicine oral liquid, are made of cicada fungus, Radix Astragali, ganoderma lucidum, ginseng and lotus seeds,
Wherein using cicada fungus as main component, but part population is to the specific proteins contained by cicada pupa that there is also allergic reactions, even
There is poisoning symptom, drug safety needs to be further increased；104286864 A of CN disclose a kind of semen astragali complanati oral solution,
It includes the 19 taste medicinal material such as semen astragali complanati, mulberries, Radix Angelicae Sinensis, and prescription is complicated, substantially increases the difficulty of quality control in production process,
It is unfavorable for large-scale promotion application；Sieve disclosed in Semen Cuscutae oral solution, 104888158 A of CN disclosed in 104305205 A of CN
There is also similar problems for thizoma curculiginis oral solution disclosed in cloth sesame slices oral solution, 106174483 A of CN.105055569 A of CN are public
A kind of shark fin bone meal herbal health care oral solution is opened, comprising the cartilage in shark shark's fin in prescription, in view of there is no at present
Ripe shark cultural technique will certainly aggravate the illegal hunting behavior for shark, be unfavorable for biometric safeguard after promoting the use of
Diversity.105477182 A of CN disclose a kind of filefish fish oil herbal health care oral solution, include from filefish liver in prescription
The filefish fish oil extracted in the leftover bits and pieces such as dirty, ovary, the main extract part in view of tetraodotoxin are ovary and liver, are used
Medicine safety needs to be further increased.
The fruit of Chinese wolfberry (also known as beet, red ear pendant, frame) be Solanaceae Lycium matrimony vine (Lycium chinense
Mill.) or the ripening fruits of lycium barbarum (Lycium barbarum L.), main product is in provinces such as Ningxia, Hebei, Gansu, Qinghai
Area, the wherein quality leadership of lycium barbarum are known as the township of matrimony vine in all parts of the country.The fruit of Chinese wolfberry is mild-natured, sweet in flavor, Return liver, kidney, lung
Through for nourishing liver and kidney, improving eyesight, moistening lung.Rich in polysaccharide (such as polysaccharides, i.e. polysaccharide and more peptide or proteins in the fruit of Chinese wolfberry
The conjugate that matter is formed), vitamins (such as riboflavin, niacin, ascorbic acid) and minerals class (such as copper, iron, zinc, manganese,
Magnesium, selenium, calcium etc.) ingredient.Pharmacology of Chinese materia medica research shows that：The fruit of Chinese wolfberry has the work(improved the immunity of the human body to a certain extent
Effect, but oral solution as main component is made with the fruit of Chinese wolfberry and is not yet seen in document report.
Invention content
The mouth as main component for improving the immunity of the human body is made with the fruit of Chinese wolfberry the purpose of the present invention is to provide a kind of
Liquid and preparation method thereof is taken, to make up blank in the prior art.
To achieve the goals above, the present invention adopts the following technical scheme that：
A kind of oral solution for improving immunity is made of following component in parts by weight：20~50 portions of matrimony vines
Son, 3~6 parts of sealworts, 2~5 parts of Radix Polygalaes, 1~3 part of rhodiola root, 3~6 parts of cortex acanthopanacis, 3~6 portions of smilaxs, 2~5 parts of Radix Glycyrrhizaes, 3
~6 parts of yellow rice wine, 30~60 parts of purified waters, preferably 30 portions of fruits of Chinese wolfberry, 5 parts of sealworts, 3 parts of Radix Polygalaes, 2 parts of rhodiola roots, 5 parts of cortex acanthopanacis, 5
Part smilax, 3 portions of Radix Glycyrrhizaes, 5 parts of yellow rice wine, 40 parts of purified waters.
In above-mentioned oral solution, the sealwort is Liliaceae HUANGJING ZANYU CAPSULE sealwort (Polygonatum sibiricum
Redoute), P. cyrtonema (Polygonatum cyrtonema Hua), Jin Shi sealworts (Polygonatum kingianum
Coll et Hemsl.) or congener root, main product is in provinces and regions such as Henan, Hebei, the Inner Mongol, Shandong, Shanxi.Sealwort
Flat, sweet in flavor, returns spleen, lung, kidney channel for nourishing Yin and moistening lung, are invigorated the spleen and benefited qi.Steroid saponin (such as Herba Polygoni sibirici is rich in sealwort
Glycosides A) and polysaccharide (such as Siberian solomonseal rhizome polysaccharide A) ingredient.
In above-mentioned oral solution, the Radix Polygalae is Polygalaceae polygala Radix Polygalae (Polygala tenuifolia
Willd.) or the root of wide leaf Radix Polygalae (Polygala sibiricaL.), main product is in provinces such as Shanxi, Shaanxi, Jilin, Henan.Radix Polygalae
Slightly warm in nature, acrid flavour, hardship, return lung, the heart channel of Hang-Shaoyin are had one's ideas straightened out for antitoxic heart-soothing and sedative, eliminating the phlegm, the carbuncle that disappears goes to swell.Triterpene saponin is rich in Radix Polygalae
(such as polygalic acid A) and xanthene ketone (such as Radix Polygalae xanthone III) ingredient.
In above-mentioned oral solution, the rhodiola root is Crassulaceae Rhodida plant rhodiola root (Rhodiola rosea
L. herb), main product is in provinces and regions such as Heilungkiang, Jilin, Tibet, Yunnan, Ningxia.Rhodiola root is cold in nature, sweet in flavor, puckery, distributed in lung channel, uses
In tonifying Qi clearing lung-heat, intelligence development nourishing heart, controlling of bleeding with astringents, eliminating stasis to subdue swelling.Tyrosol and its glycoside, flavonoids (such as kaempferia galanga are rich in rhodiola root
Phenol), Coumarins (such as umbelliferone) ingredient.
In above-mentioned oral solution, the cortex acanthopanacis is Araliaceae Lysionotus carnosus Hemsl. (Lysionotus pauciflorus Maxim.) platymiscium acanthopanax gracilistylus (Acanthopanax
Gracilistylus W.W.Smith) root skin, main product is in Hubei, Henan, Anhui and other places.Cortex acanthopanacis is warm-natured, and acrid flavour, hardship are returned
Liver and kidney channel, for wind-damp dispelling, strengthening the bones and muscles.Lignanoids (such as eleutheroside) ingredient is rich in cortex acanthopanacis.
In above-mentioned oral solution, the smilax is Liliaceae smilax plant smilax (Smilax glabra
Roxb. stem tuber), main product is in Yangtze river basin south each province.Smilax is mild-natured, sweet in flavor, light, Return liver, stomach, for detoxifying, removing
Wet, sharp joint.Smilacin constituents are rich in smilax.
In above-mentioned oral solution, the Radix Glycyrrhizae is pulse family glycyrrhiza genus Radix Glycyrrhizae (Glycyrrhiza uralensis
Fisch root), wild varieties are distributed mainly on Xinjiang, the Inner Mongol, Ningxia, Gansu, Shanxi, and artificial growth kind main product is in new
Boundary, the Inner Mongol, the Hexi Corridor in Gansu and countries of Ningxia Hui Autonomous Region area.Radix Glycyrrhizae is mild-natured, sweet in flavor, the thoughts of returning home, lung, spleen, stomach, for mending
Spleen QI invigorating moistens the lung and relieve the cough, relieving spasm to stop pain, mitigates pharmacological property.It is (such as sweet rich in triterpene saponin (such as glycyrrhizic acid) and flavonoids in Radix Glycyrrhizae
Careless element) ingredient.
In above-mentioned oral solution, the yellow rice wine be with rice, milled glutinous broomcorn millet, maize etc. for primary raw material, through adding the sugar such as song, yeast
Change fermented wine made of leavening brewing.Yellow rice wine is warm-natured, sweet in flavor, bitter, pungent, toxic, the thoughts of returning home, liver, lung, stomach, has promoting blood circulation logical
The effect of network, expelling wind and clearing away cold, for chill numbness pain, Spasm of the tendons, the obstruction of qi in the chest, trusted subordinate's crymodynia etc..Yellow rice wine belongs to low brewed wine,
In contain 12%~18% (v/v) ethyl alcohol, and containing maltose, glucose and succinic acid, lactic acid, amino acid, esters
With the ingredients such as aldehydes.
In above-mentioned oral solution, the purified water be by drinking water through the way of distillation, ion-exchange, hyperfiltration or other
Water for pharmaceutical purposes made from suitable method.
The preparation method of above-mentioned oral solution comprising following steps：
1) fruit of Chinese wolfberry of formula ratio, sealwort, Radix Polygalae, rhodiola root, cortex acanthopanacis, smilax and Radix Glycyrrhizae are crushed respectively, crosses 60
~100 mesh sieve, and obtain medlar powder, sealwort powder, Radix Polygalae powder, rhodiola root powder, cortex acanthopanacis powder, smilax powder and licorice powder；
2) ethyl alcohol of 3~5 times of volumes of the mixture of the medlar powder obtained in step 1), sealwort powder and licorice powder is returned
Stream extraction 15~20 hours, filters out the dregs of a decoction, filtrate is concentrated into no alcohol taste, obtains medicinal extract I after extraction；It will be obtained in step 1)
The isopropanol refluxing extraction 15 of 3~5 times of volumes of the mixture of the Radix Polygalae powder, rhodiola root powder, cortex acanthopanacis powder and the smilax powder that arrive
~20 hours, the dregs of a decoction are filtered out after extraction, filtrate is concentrated into no alcohol taste, obtains medicinal extract II；
3) yellow rice wine of formula ratio is heated to 50~60 DEG C, is divided into after two parts and distinguishes dilution step 2) in obtained leaching
Cream I and medicinal extract II, by after dilution medicinal extract I and medicinal extract II be uniformly mixed, add the purified water of formula ratio, be uniformly mixed again
Low temperature sterilization and sterile filling are carried out afterwards, obtain the oral solution for improving immunity.
In a preferred embodiment, the fruit of Chinese wolfberry described in step 1), sealwort, Radix Polygalae, rhodiola root, cortex acanthopanacis, soil
Poria cocos and liquorice is dry product.
In a preferred embodiment, the mesh number sieved described in step 1) is 60 mesh.
In a preferred embodiment, the mixture of medlar powder described in step 2), sealwort powder and licorice powder is with 5
The alcohol reflux of times volume extracts 20 hours.
In a preferred embodiment, Radix Polygalae powder described in step 2), rhodiola root powder, cortex acanthopanacis powder and smilax powder
3 times of volumes of mixture isopropanol refluxing extraction 15 hours.
In a preferred embodiment, the heating temperature of yellow rice wine described in step 3) is 60 DEG C.
The application method of above-mentioned oral solution is as follows：For there is the patient of hypoimmunity or subhealth symptom, often
Day respectively takes 5~10mL of oral solution after getting up and before sleep, is equipped with warm water delivery service, is used continuously 4~8 weeks, you can effectively slow
Decorrelation symptom.
Compared with prior art, there are following advantages using the present invention of above-mentioned technical proposal：
1) lack in the prior art and the oral solution as main component for improving immunity is made with the fruit of Chinese wolfberry, the present invention is proper
Above-mentioned blank is just compensated for, the application field of the fruit of Chinese wolfberry has been widened；
2) class Chinese medicine is nourished to assist the fruit of Chinese wolfberry to play the effect of improving immunity using sealwort and rhodiola root etc., be aided with remote
Sedative action, the clearing damp effect of cortex acanthopanacis and the detoxication of smilax of will, and kept away simultaneously come coordinating the drug actions of a prescription by Radix Glycyrrhizae
Exempt from the sense of discomfort that the intrinsic smell of traditional Chinese medicine ingredients is brought, improves the compliance of patient；
3) it is demonstrated experimentally that the oral solution prescription of the present invention is simple, body immunity can be effectively improved, and preparation method is easy
It is easy, it is suitable for exploitation into corresponding health products, great market prospects.
Specific implementation mode
Technical scheme of the present invention is made below in conjunction with specific embodiment further elucidated above.The following example is only used
In the explanation and illustration present invention, and should not be taken as limiting the scope of the invention.Unless otherwise stated, institute in the following example
Instrument, reagent, material for using etc. can be obtained by routine business means.
Embodiment 1- embodiments 5：Preparation for the oral solution for improving immunity.
The oral solution for improving immunity is prepared according to the formula in table 1, preparation process is as follows：
(1) the dry fruit of Chinese wolfberry, sealwort, Radix Polygalae, rhodiola root, cortex acanthopanacis, smilax and Radix Glycyrrhizae are crushed respectively, mistake
60 mesh sieve, and obtain medlar powder, sealwort powder, Radix Polygalae powder, rhodiola root powder, cortex acanthopanacis powder, smilax powder and licorice powder；
(2) by 5 times of volume (embodiments 1 of the mixture of the medlar powder, sealwort powder and the licorice powder that are obtained in step (1)
Dosage in~5 is respectively 155mL, 275mL, 205mL, 265mL and 190mL) alcohol reflux extract 20 hours, extraction finishes
After filter out the dregs of a decoction, filtrate is concentrated into no alcohol taste, obtains medicinal extract I；The Radix Polygalae powder, rhodiola root powder, slender acanthopanax that will be obtained in step (1)
The mixture of skin powder and smilax powder with 3 times of volumes (dosage in Examples 1 to 5 be respectively 60mL, 30mL, 36mL, 33mL and
Isopropanol refluxing extraction 45mL) 15 hours filters out the dregs of a decoction after extraction, filtrate is concentrated into no alcohol taste, obtains medicinal extract II；
(3) yellow rice wine is heated to 60 DEG C, is divided into the medicinal extract I and medicinal extract for distinguishing after two parts and being obtained in dilution step (2)
II, by after dilution medicinal extract I and medicinal extract II be uniformly mixed, add purified water, again after mixing carry out low temperature sterilization and
Sterile filling obtains the oral solution for improving immunity.
Table 1. is used to improve the prescription and dosage of the oral solution of immunity
Test example 1：The quality testing of oral solution of the present invention.
According to《GB 16740-2014 national food safety standard health foods》In detection project and detection method to reality
The oral solution applied in example 1~5 is detected, and the results are shown in Table 2.As shown in Table 2, indices are met the requirements of the standard.
The quality inspection result of 2. oral solution of table
Test example 2：The study on the stability of index components in oral solution of the present invention.
Oral solution in embodiment 5 is positioned at ambient temperature at shady and cool dry, the 1st after placement, 4,7,
10, it samples within 15 and 30 days, is calculated as 100% with the content of various active constituents in the 1st day sampling sample, measures each sub-sampling thereafter
The relative amount of middle tie element investigates storage stability of the oral solution under the drying condition of room temperature cool place whereby, and result is such as
Shown in table 3.
The storage stability result of index ingredient in 3. oral solution of table.
As shown in Table 3, in 30 days detection cycles, it is placed in chief active in the oral solution under the drying condition of room temperature cool place
The relative amount of ingredient can maintain 90% or more, show that the oral solution can be protected effectively in about 4 weeks storage times
Stay the activity of leading indicator ingredient.
Test example 3：The drug safety of oral solution of the present invention is investigated.
Content of the test：Acute toxicity test；Four genetic toxicity tests (are replied with reference to the bacterium of GB 15193.4-2014
Mutant test, with reference to the mammalian erythropoietin micronucleus test of GB 15193.5-2014, with reference to the small of GB 15193.7-2003
Mouse sperm malformation test, the Mouse Spermatogonial Cells chromosomal aberration test with reference to GB 15193.8-2014)；Rat tradition teratogenesis
Experiment；30 days feeding trials of rat.
Test result：The rats and mice LD50 of passing through mouth of two kinds of genders of oral solution pair of the present invention is all higher than 10g/kg weight, according to
Acute toxicity is classified, and belongs to practical non-poisonous material；Four genetic toxicity test results are feminine gender；Rat traditional teratogenicity test is not shown
Teratogenesis is shown；After 30 days feeding trials of rat, clinical indices, hematological indices and blood biochemical analysis index are just
Often, compared with the control group, difference is not notable for experimental group.
Test example 4：The health-care efficacy clinical test of oral solution of the present invention.
(1) subject：
60 subjects, men and women is fifty-fifty, average age 40 years old, wherein 35 subjects are in sub-health state, has thermophilic
It sleeps, the symptoms such as fatiguability, loss of appetite, decrease of memory, attention can not be concentrated, are slow in reacting, and leucocyte in vivo
Par is less than 4000/ μ L.
(2) application method：
Oral solution (the specification in embodiment 5 is used for subject：10mL/ branch), it is each after getting up and before sleep daily to take
With 1, it is equipped with a small amount of warm water delivery service, is used continuously 4 weeks.
(3) test result：
After continuously taking oral solution of the present invention 4 weeks, leucocyte par is less than 35 subject's bodies of normal value
Interior leucocyte par restores to 4000/ μ L or more, and sub-health status is improved；It is white thin in remaining subject's body
Born of the same parents' par is compared with before treatment without significant difference.It can be seen that oral solution of the present invention can effectively improve sub-health population
Immunity of organisms, improve sub-health status.
Claims (8)
1. a kind of oral solution for improving immunity, it is characterised in that：
The oral solution is made of following component in parts by weight：20~50 portions of fruits of Chinese wolfberry, 3~6 parts of sealworts, 2~5 parts it is remote
Will, 1~3 part of rhodiola root, 3~6 parts of cortex acanthopanacis, 3~6 portions of smilaxs, 2~5 portions of Radix Glycyrrhizaes, 3~6 parts of yellow rice wine and 30~60 parts of purifying
Water.
2. the oral solution according to claim 1 for improving immunity, it is characterised in that：
The oral solution is made of following component in parts by weight：30 portions of fruits of Chinese wolfberry, 5 parts of sealworts, 3 parts of Radix Polygalaes, 2 parts of red scapes
It, 5 parts of cortex acanthopanacis, 5 portions of smilaxs, 3 portions of Radix Glycyrrhizaes, 5 parts of yellow rice wine and 40 parts of purified waters.
3. the preparation method according to claim 1 or 2 for improving the oral solution of immunity, it is characterised in that：
The preparation method includes the following steps：
1) fruit of Chinese wolfberry of formula ratio, sealwort, Radix Polygalae, rhodiola root, cortex acanthopanacis, smilax and Radix Glycyrrhizae are crushed respectively, crosses 60~100
Mesh sieves, and obtains medlar powder, sealwort powder, Radix Polygalae powder, rhodiola root powder, cortex acanthopanacis powder, smilax powder and licorice powder；
2) mixture of the medlar powder obtained in step 1), sealwort powder and licorice powder is carried with the alcohol reflux of 3~5 times of volumes
It takes 15~20 hours, the dregs of a decoction is filtered out after extraction, filtrate is concentrated into no alcohol taste, obtains medicinal extract I；By what is obtained in step 1)
The isopropanol refluxing extraction 15~20 of 3~5 times of volumes of mixture of Radix Polygalae powder, rhodiola root powder, cortex acanthopanacis powder and smilax powder
Hour, the dregs of a decoction are filtered out after extraction, filtrate is concentrated into no alcohol taste, obtains medicinal extract II；
3) yellow rice wine of formula ratio is heated to 50~60 DEG C, is divided into after two parts and distinguishes dilution step 2) in obtained medicinal extract I
With medicinal extract II, by after dilution medicinal extract I and medicinal extract II be uniformly mixed, add the purified water of formula ratio, again after mixing
Low temperature sterilization and sterile filling are carried out, the oral solution for improving immunity is obtained.
4. preparation method according to claim 3, it is characterised in that：
The fruit of Chinese wolfberry described in step 1), sealwort, Radix Polygalae, rhodiola root, cortex acanthopanacis, smilax and Radix Glycyrrhizae are dry product.
5. preparation method according to claim 3, it is characterised in that：
The mesh number sieved described in step 1) is 60 mesh.
6. preparation method according to claim 3, it is characterised in that：
The alcohol reflux of 5 times of volumes of the mixture of medlar powder described in step 2), sealwort powder and licorice powder extracts 20 hours.
7. preparation method according to claim 3, it is characterised in that：
The isopropanol time of Radix Polygalae powder described in step 2), 3 times of volumes of mixture of rhodiola root powder, cortex acanthopanacis powder and smilax powder
Stream extraction 15 hours.
8. preparation method according to claim 3, it is characterised in that：
The heating temperature of yellow rice wine described in step 3) is 60 DEG C.
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Cited By (1)
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Application publication date: 20181102 |