CN108704056A - A kind of formula and its application method applied to odontopathy - Google Patents
A kind of formula and its application method applied to odontopathy Download PDFInfo
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- CN108704056A CN108704056A CN201810981802.3A CN201810981802A CN108704056A CN 108704056 A CN108704056 A CN 108704056A CN 201810981802 A CN201810981802 A CN 201810981802A CN 108704056 A CN108704056 A CN 108704056A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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Abstract
The present invention relates to a kind of formulas and its application method applied to gum disease.This formula includes Co-Q10, aloe, probiotics.The invention also provides a kind of application methods of the formula applied to odontopathy, early daily, and after dinner, using Co-Q10 chewable tablets and probiotics lozenge, the packet bath of aloe pulvis one is used containing mouth.It is mutually cooperateed between three kinds of nutrients in the present invention, it is complementary.Existing quick anti-inflammatory, control symptom effect, also has long-term homeostasis, the effect of self-prevention and adjusting, and it is all convenient for carrying and uses, packaging is simple, liquid of not gargling.
Description
Technical field
The present invention relates to treatment gingivitis and periodontitis technical field, specially a kind of formula applied to gum disease and
Its application method.
Background technology
Adult tooth disease (including periodontitis and secondary gingivitis) may is that the highest a kind of disease of incidence.According to
Different statistics and estimation, the incidence of periodontosis can reach the 90~95% of population.Periodontitis be due to a variety of bodies and
Environmental factor causes the undue growth of oral cavity pathogen and makes gum redness and the inflammation of bleeding.Periodontitis is such as developed as one pleases, then
Infection continues, and bacterium corrodes periodontium, causes gum and destruction of bone atrophy, final loss of tooth.Periodontal disease is except influence
Other than tooth itself, gastrointestinal health can be also influenced.In recent years clinical research confirmation can increase the wind of tumour and angiocardiopathy
Danger.Prevent periodontal disease and be directed not only to many people, and has very important meaning for improving entire health quality.
It will medically surround and cover and be known as gum in periodontal soft tissue, the acute and chronic for betiding gingiva tissue is scorching
Disease is known as gingivitis, shows as bleeding gums, redness and distending pain, continues development and invades sclerous tissues, generates periodontitis, including gum
Performance of the inflammation and general disease of tissue in gum.
Gingivitis is manifested initially by gum redness, easy bleeding.Often it is not taken seriously.The generation of most of gingivitis and
Process is related with localized bacterial infection and its degree.However there are many natural and environmental factors that can cause gum swelling or bacterium
It is susceptible.These include heredity and age, and in puberty, pregnancy, the variation of hormone, smoking is tired, sleep insufficiency, unbalanced nutrition,
Diabetes, infection, some drugs etc..Obviously, obtain gingivitis risk factors have part also have it is whole.So prevent must be from
Part is set about, while taking into account whole body.
Periodontitis is mainly the chronic inflammation of the Periodontal Supporting Tissue caused by local factor, as oulitis fails to control in time
It treats, inflammation can be diffused into parodontium, alveolar bone and cementum to deep layer from gum and develop into gingivitis, due in early days mostly without bright
Aobvious subjective symptoms and it is easily ignored, it is more serious when having symptom, or even tooth cannot have been retained, thus must reinforce declaring
Religion makes patient's early presentation and in time treatment.
Best treatment is to prevent, and correct effective common oral health is most important link.But for having occurred
The early stage periodontal disease of symptom, such as gum redness, the periodontitis of bleeding is not had at home in addition to suggesting being gargled using antimicrobial fluid
It is more natural, safety, effective method.Best precautionary measures should be set about from the cause of disease, while inverse based on the understanding to the cause of disease
Turn its lesion environment.Several factors can promote the undue growth of oral cavity pathogen.Smoking and polysaccharide food are reduced, frequently brushes teeth and makes
It is necessary with dental floss etc..But some health status locally or systemically must have preferred solution.
Invention content
In view of the deficiencies of the prior art, this application provides a kind of formulas and its application method applied to odontopathy.
The technical solution of the application is as follows：
A kind of formula applied to odontopathy, includes Co-Q10, aloe, probiotics, may also include other auxiliary at
Point.The ratio of Co-Q10, aloe extract, probiotics is as follows：
Co-Q10,80~120 parts, in terms of mass number；
Aloe, 200~400 parts, in terms of mass number；
Probiotics, 1200~1800 parts, in terms of mass number.
Preferably, the dosage form used in Co-Q10 is chewable formulation, and the dosage form used in aloe is oral solution type or pulvis, benefit
Dosage form used in raw bacterium is buccal tablet.
Preferably, aloe extracts from aloe full leaf, and gets rid of aloin and aloe-emodin simultaneously.
Preferably, probiotics is Bacillus acidi lactici class, it is furthermore preferred that being rhamnose lactic acid bacteria.
Preferably, the amount of bacteria of probiotics can be between 1~500,000,000.
The technical program further comprises a kind of method using above-mentioned formula, includes the following steps：
(1) early daily, after evening brushes teeth, using buccal lozenge type probiotics 1, the buccal lozenge type probiotics is made to be contacted with gums；
(2) early daily, after evening brushes teeth, using masticatory pattern Co-Q10 1, the masticatory pattern Co-Q10 is made to be connect with gums
It touches；
(3) add water to be configured to aloe gargle aloe powder, be performed in multiple times and gargle.
Preferably, the service life of buccal lozenge type probiotics is 30 days in step (1), the masticatory pattern Co-Q10 in step (2)
Service life be 30 days, the service life of the aloe gargle in step (3) is 14 days.
The technical program further comprises the application in odontopathy field using this formula.
The technical program further comprises the application in odontopathy field using the method for this formula.
Preferably, Co-Q10 uses CoQ10, for over-65s the elderly, using reduced coenzyme Q 10.
Co-Q10 is a particularly important coenzyme for executing human body physiological function.It is performance during cell production capacity
What it was acted on.So it has cardioprotection, brain, liver, the critical function to the very sensitive internal organs of energy requirement such as kidney.Simultaneously
Q10 is also a unique antioxidant, most important for protection mitochondria tissue (cellular energy generating unit).In vivo
The source of Q10 can be divided into external source and two kinds endogenous.External source is mainly derived from food.Amount containing Q10 is more next than more rich in food
From in the internal organ of animal.Human body itself also generates a certain amount of Q10, but with the increase at age, the amount of itself synthesis can be substantially
Degree is reduced.So common people have the insufficient potential dangers of Q10.Some drugs, for example reduce his class D drug of cholesterol, meeting
Block the approach of Q10 synthesis.When internal Q10 deficiencies, cell is because influence the normal performance of its function without energy and power.
The relationship for lacking Q10 and periodontal disease in gum local cells has been clinical trial confirmation.The additional supplement Q10 of adult is to periodontal
All it is beneficial with holistic health.There are two types of molecular conformations for Co-Q10：Prototype (or oxidized form Ubiquinone) and reduced form
(Ubiquinol).Reduced form has oxidation resistance.The two is in an equilibrium state mutually converted in the cell.With year
Age increases, and restoring the ability of Q10 can weaken.
The use of aloe has had history of more than one thousand years, mainly in gastrointestinal tract and wound healing art.Present research is found
The vitamin that aloe is not only wanted containing hundreds of needed by human body, minerals, amino acid etc., it also has natural antibacterial ability.Aloe
In mucopolysaccharide for improve immunity of organisms have exact effect.There are many aloe products in the market, but most of is one
Kind Sugared beverages, active ingredient containing aloe are seldom.Many active ingredients of aloe exist in aloe epidermis, but in aloe epidermis
There are aloin (Aloin) and aloe-emodin (Aloe Emodin), they have and cause enterocinesia excessively hyperfunction and diarrhea occur
Problem.So best aloe extract must be obtained in its full leaf, but it is removed simultaneously can lead to the aloin of diarrhea
And aloe-emodin.
Probiotics is the microorganism for contributing to health and maintaining the ecological balance colonized on human body.Most of is thin
Bacterium also has a small amount of fungi and protozoa.Most containing probiotics with gastrointestinal tract in human body, it is to gastrointestinal health and general immunity work(
Very important effect can be played.Probiotics exists in oral cavity and urogenital mucous membrane simultaneously.For safeguarding related organ
Local immunity it is extremely important.Research in recent years has confirmed probiotics to weight and metabolism, cardiovascular health, sleep and
Mood etc. has the influence of highly significant.The rapid development on basis and clinical research to probiotics, makes the use of probiotics become
In more precisely and effective.Probiotics in human body has thousands of kinds, also there is nearly 500 kinds of different bacteriums in oral cavity.Select correlation strong
Strain, bacterial strain is extremely important.According to the understanding to Oral normal flora periodontal disease is prevented using probiotics with existing
Clinical research, it has been found that playing the role of many strains has potential prevention and improve periodontal disease.Such as following strain：A) newborn
Acidfast bacilli class, rhamnose lactic acid bacteria (Lactobacillus reuteri), short Bacillus acidi lactici (Lactobacillus
Brevis), Lactobacillus casei (Lactobacillus casei), saliva Bacillus acidi lactici (Lactobacillus
salivarius)；B) hammer mushroom, Streptococcus oralis (Streptococcus oralis), streptococcus uberis
(Streptococcus uberis), Streptococcus cricetus (Streptococcus rattus)；And c) Pediococcus acidilactici
(Pediococcus acidilactici)。
Come for a long time the study found that the content for the people's topical co-enzyme Q 10 for having gingivitis and other teeth to suffer from is low compared with normal person.Although
Its reason and mechanism are not yet fully apparent from, but giving oral Co-Q10 can make gum disease be eased and improve.Q10 is
Important coenzyme during one cell production capacity, while being a special antioxidant again, these functions for cell from
Body health resists pathogenic bacteria invasion and plays an important role；In addition it is always the administration of mouth disease prevention and treatment for gargle
Approach.That usually used is gluconic acid chlorhexidine (or chlorohexidene chlorhexidine gluconate).Chlorohexidene is one
The chemical antiseptic of kind, in addition to there may be allergic reaction, also many adverse side effects, including color spot is formed in oral cavity, pharynx
Larynx stimulates, dysgeusia etc..Trend and research emphasis in recent years is advantageous to human body holistic health, while being improved oral cavity office again
The plant component of portion's disease resistance, aloe are plants in wherein very unique and having many clinical researches supports one.Aloe
Use the history for having more than one thousand years.It is an immunomodulator, can improve the immunity of human body, while being natural anti-cause again
Germ agent, also very strong healing ability.Research have shown that aloe water gargle with chlorohexidene gargle for treatment gingivitis have
Same benefit, but without its side effect.And aloe gargle after can swallow, to entire gastrointestinal tract even whole body health have product
The effect of pole；Undue growth of the pathogenic bacteria on tooth and gum also makes be in the presence of flora imbalance in oral cavity.Pathogenic bacteria
Undue growth and its toxin may increase related with cardiovascular and tumor risk caused by gum disease.Intraoral cause simultaneously
After germ is swallowed, also increase the risk of gastrointestinal bacterial flora disorder.Beneficial bacterium is the natural enemy of pathogenic bacteria in oral cavity, at present to probiotics
Therapy for the research that periodontal disease prevents and treats come into one it is new more accurate, it is more personalized to select effective flora
Period.It is believed that this method can not only improve the balance of Oral Bacteria state, also there is positive effect to the health of whole body bacterium state.Each
The selection of nutrient has research to support, for Co-Q10, can improve the energetic supersession of topical epithelial cell, make
Cell is healthier, enhances function and self-repairing capability.Q10 is also a very effective antioxidant simultaneously, can be helped
Alleviate inflammation, defencive function and eucaryotic cell structure.For aloe, aloe has anti-inflammatory, antibacterial, assisted tissue to safeguard thin
The effect of born of the same parents and beneficial bacterium normal microenvironment.For probiotics, it can directly inhibit the growth of harmful bacteria (pathogenic bacteria)
And breeding, keep self-control in oral cavity, the effect of prevention.
Due to using the technology described above, the advantageous effect of the application is：
First, it mutually cooperates between three kinds of nutrients in the present invention, it is complementary.Existing quick anti-inflammatory, control symptom are made
With also having long-term homeostasis, the effect of self-prevention and adjusting.
Second, three kinds of nutrients are all convenient for carrying and use in the present invention, and packaging is simple, liquid of not gargling.
Specific implementation mode
The present invention is specifically described below by embodiment.It is necessarily pointed out that following embodiment is served only for
The present invention is described further, should not be understood as limiting the scope of the invention, person skilled in art according to
Aforementioned present invention content makes some nonessential modifications and adaptations to the present invention, still falls within protection scope of the present invention.
Embodiment 1
A kind of formula applied to odontopathy is grouped as by the group of following parts by weight：100 parts of Co-Q10, aloe 300
Part, 1600 parts of Lactobacillus rhamnosus.Dosage form used in Co-Q10 is chewable formulation, and the dosage form used in aloe is pulvis, rhamnose
Dosage form used in lactobacillus is buccal tablet.
The application method that should be used for the formula of odontopathy includes following steps：
(1) early daily, it after evening brushes teeth, using buccal lozenge type Lactobacillus rhamnosus 1, is allowed to come into full contact with gums, 1 mouse
Lee's sugar lactobacillus is greatly containing about bacterium 200,000,000, twice daily, is used continuously 30 days；
(2) early daily, after evening brushes teeth, using masticatory pattern Co-Q10, it is allowed to come into full contact with gums, twice daily, continuously
It uses 30 days；
(3) the time warm water 60ml that aloe powder is not eaten food in one day is configured to 100% aloe gargle, it will
Gargle, which is performed in multiple times, gargles, and rinse time is more than 5 minutes in total, is used continuously 15 days.
Preferably, the service life of buccal lozenge type probiotics is 30 days in step (1), the masticatory pattern Co-Q10 in step (2)
Service life be 30 days, the service life of the aloe gargle in step (3) is 14 days.
After being 30 days, 30 days using the period of above-mentioned formula, curative effect evaluation is carried out according to rear effect is used.Curative effect is commented
The standard estimated is：
It cures：Pain disappears, and gum subsides without bleeding, swelling, and appearance restores normal.
It is effective：Pain relief, gum swelling are subsided, and appearance returns to normal.
In vain：Symptom is not improved after treatment.
Comparative example 1
A kind of formula applied to odontopathy does not use probiotics using aloe and Co-Q10.
Comparative example 2
A kind of formula applied to odontopathy does not use Co-Q10 using aloe and probiotics.
Comparative example 3
A kind of formula applied to odontopathy does not use aloe using probiotics and Co-Q10.
Comparative example 4
A kind of formula applied to odontopathy uses aloe, Co-Q10, probiotics.
Efficacy result and analysis
80 gingivitis out-patients are randomly selected, wherein man 43, female 37, age 19-62 Sui is randomly divided into 4 groups,
First group of 20 people respectively, second group of 20 people, 20 people of third group and the 4th group of 20 people, first group uses comparative example 1, second group of comparison
Example 2, third group comparative example 3, the 4th group of comparative example 4.After this patent application method 30 days, table 1 is obtained.
Table 1：4 comparative example efficacy results
| Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | |
| Cure number | 4 | 3 | 4 | 8 |
| Effective number | 6 | 6 | 5 | 9 |
| Invalid number | 10 | 11 | 11 | 3 |
| Cure rate | 20% | 15% | 20% | 40% |
| It is efficient | 50% | 45% | 45% | 85% |
As can be known from Table 1, efficient to add after effective number and the ratio of sum to cure number, cure rate be cure number with it is total
Than.The effective percentage of the comparative example that can visually see from table 14 is 85%, cure rate 40%, good effect, and patient is invariably
Good reaction.
The foregoing is a further detailed description of the present application in conjunction with specific implementation manners, and it cannot be said that this Shen
Specific implementation please is confined to these explanations.For those of ordinary skill in the art to which this application belongs, it is not taking off
Under the premise of conceiving from the application, a number of simple deductions or replacements can also be made, all shall be regarded as belonging to the protection of the application
Range.
Claims (10)
1. a kind of formula applied to odontopathy, which is characterized in that include Co-Q10, aloe, probiotics.
2. formula according to claim 1, which is characterized in that based on mass number, it includes have Co-Q10 80~120
Part, 200~400 parts of aloe, 1200~1800 parts of probiotics.
3. formula according to claim 1, which is characterized in that the dosage form used in the Co-Q10 is chewable formulation, described
Dosage form used in aloe is oral solution type or pulvis, and the dosage form used in the probiotics is buccal tablet.
4. formula according to claim 1, which is characterized in that the aloe extracts from aloe full leaf, and
Get rid of aloin and aloe-emodin simultaneously.
5. formula according to claim 1, which is characterized in that the probiotics is rhamnose lactic acid bacteria.
6. formula according to claim 1, which is characterized in that the amount of bacteria of the probiotics can be between 1~500,000,000.
7. a kind of using the method being formulated described in claim 1, which is characterized in that include the following steps：
(1) early daily, after evening brushes teeth, using buccal lozenge type probiotics 1, the buccal lozenge type probiotics is made to be contacted with gums；
(2) early daily, after evening brushes teeth, using masticatory pattern Co-Q10 1, the masticatory pattern Co-Q10 is made to be contacted with gums；
(3) add water to be configured to aloe gargle aloe powder, be performed in multiple times and gargle.
8. the method according to the description of claim 7 is characterized in that the service life of buccal lozenge type probiotics is 30 in step (1)
It, the service life of the masticatory pattern Co-Q10 in step (2) is 30 days, and the service life of the aloe gargle in step (3) is
14 days.
9. according to application of claim 1~6 any one of them formula in odontopathy field.
10. according to application of claim 7~8 any one of them method in odontopathy field.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050196359A1 (en) * | 2004-03-03 | 2005-09-08 | D'amelio Frank S.Sr. | Method and composition for treating oral bacteria and inflammation |
| US20070110683A1 (en) * | 2005-11-16 | 2007-05-17 | Gosmile, Inc. | Oral care formulation |
| CN108310122A (en) * | 2018-02-02 | 2018-07-24 | 云南中京国建投资有限公司 | A kind of symphysis unit composition preventing oral peculiar smell and its preparation and application |
| CN108338361A (en) * | 2017-01-24 | 2018-07-31 | 丰华生物科技股份有限公司 | Food, oral cleaning and pharmaceutical composition for inhibiting lactic acid bacteria strain of oral pathogenic bacteria |
-
2018
- 2018-08-27 CN CN201810981802.3A patent/CN108704056A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050196359A1 (en) * | 2004-03-03 | 2005-09-08 | D'amelio Frank S.Sr. | Method and composition for treating oral bacteria and inflammation |
| US20070110683A1 (en) * | 2005-11-16 | 2007-05-17 | Gosmile, Inc. | Oral care formulation |
| CN108338361A (en) * | 2017-01-24 | 2018-07-31 | 丰华生物科技股份有限公司 | Food, oral cleaning and pharmaceutical composition for inhibiting lactic acid bacteria strain of oral pathogenic bacteria |
| CN108310122A (en) * | 2018-02-02 | 2018-07-24 | 云南中京国建投资有限公司 | A kind of symphysis unit composition preventing oral peculiar smell and its preparation and application |
Non-Patent Citations (2)
| Title |
|---|
| A. VERVELLE，等: "Mouthwash solutions with microencapsuled natural extracts:Efficiency for dental plaque and gingivitis", 《REV STOMATOL CHIR MAXILLOFAC》 * |
| ALICIA MORALES,等: "Clinical Effects of Lactobacillus rhamnosus in Non-Surgical Treatment of Chronic Periodontitis: A Randomized Placebo-Controlled Trial With 1-Year Follow-Up", 《J PERIODONTOL》 * |
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Application publication date: 20181026 |