CN114983874B - A mouthwash containing Chinese medicinal volatile oil composition - Google Patents
A mouthwash containing Chinese medicinal volatile oil composition Download PDFInfo
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- 239000000341 volatile oil Substances 0.000 title claims abstract description 90
- 239000002324 mouth wash Substances 0.000 title claims abstract description 37
- 229940051866 mouthwash Drugs 0.000 title claims abstract description 34
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- APLNAFMUEHKRLM-UHFFFAOYSA-N 2-[5-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-1,3,4-oxadiazol-2-yl]-1-(3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1=NN=C(O1)CC(=O)N1CC2=C(CC1)N=CN2 APLNAFMUEHKRLM-UHFFFAOYSA-N 0.000 description 1
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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Abstract
Description
技术领域Technical field
本发明公布了一种以抑制口腔细菌为主要功能的中药精油组合物漱口液的组成及制备方法，属于口腔健康技术领域。The invention discloses the composition and preparation method of a traditional Chinese medicine essential oil composition mouthwash with the main function of inhibiting oral bacteria, and belongs to the technical field of oral health.
背景技术Background technique
在中国，口腔健康正受到前所未有的关注。随着经济的发展，生活水平的提高，人们对口腔保健的意识也大大增强。随着市场需求及消费观念的提升和变化，口腔护理产品格局已经由最初的牙膏“一统天下”渐渐升级为牙膏、牙线、牙贴、漱口液、电动牙刷等产品的共同作战。一般而言常规刷牙只能够清除牙面40％～50％的菌斑，邻面只能去30％的菌斑，而对于清除口腔软组织表面的菌斑基本无能为力。菌斑中的致病菌牙龈卟啉单胞菌通过释放毒性产物对牙周组织造成损害，最终形成牙周炎。但漱口液可深入口腔各部位，包括牙刷难接触的牙龈边缘及牙缝间，是一种很好的辅助控制菌斑措施。In China, oral health is receiving unprecedented attention. With the development of the economy and the improvement of living standards, people's awareness of oral health care has also greatly increased. With the improvement and changes in market demand and consumption concepts, the oral care product landscape has gradually upgraded from the original toothpaste "dominating the world" to a joint effort of toothpaste, dental floss, toothpaste, mouthwash, electric toothbrush and other products. Generally speaking, conventional brushing can only remove 40% to 50% of the plaque on the tooth surface, and only 30% of the plaque on the adjacent surface. It is basically unable to remove the plaque on the surface of the oral soft tissue. The pathogenic bacteria Porphyromonas gingivalis in plaque causes damage to periodontal tissue by releasing toxic products, eventually forming periodontitis. However, mouthwash can penetrate deep into all parts of the mouth, including the gum edges and between teeth, which are difficult to reach with toothbrushes. It is a good auxiliary measure to control plaque.
金黄色葡萄球菌和牙龈卟啉单胞菌是影响口腔健康的原因之一。金黄色葡萄球菌是革兰氏阳性菌、牙龈卟啉单胞菌是革兰氏阴性菌。Staphylococcus aureus and Porphyromonas gingivalis are among the causes of oral health problems. Staphylococcus aureus is a Gram-positive bacterium and Porphyromonas gingivalis is a Gram-negative bacterium.
中医理论认为胃火炽热、肾气虚亏和气血不足是导致牙龈问题的主要病因。漱口液在口腔疾病的预防及辅助治疗中起着重要的作用。目前，临床上常用的漱口液中多含有抗生素、碘、乙醇等成分，如洗必泰、含碘新型漱口液等，它们能有效减少牙菌斑中的细菌，减弱细菌产物的毒性，达到控制菌斑，预防牙龈炎、牙周炎等口腔疾病。但长期使用含有广谱抗生素的漱口液容易引起口腔菌群失调，随着使用次数的增多，产生耐药菌及二次感染的风险也越高。洗必泰类漱口液长期使用易造成牙面着色、味觉改变，不宜长时间使用，且因味苦、口感较差、局部刺激较大而不被患者接受，部分患者甚至会产生过敏引起皮疹或口炎。含碘漱口液有效碘含量不稳定，稀释后有效含量降低较快，需现用现配，给患者使用带来不便。因此，寻找天然、副作用少、有效、安全、无酒精、可长期使用的漱口液成为治疗口腔问题的新热点。Traditional Chinese medicine theory believes that hot stomach fire, deficiency of kidney qi and insufficient qi and blood are the main causes of gum problems. Mouthwash plays an important role in the prevention and auxiliary treatment of oral diseases. Currently, most commonly used mouthwashes in clinical settings contain antibiotics, iodine, ethanol and other ingredients, such as chlorhexidine, new iodine-containing mouthwashes, etc. They can effectively reduce bacteria in dental plaque and weaken the toxicity of bacterial products. Achieve plaque control and prevent oral diseases such as gingivitis and periodontitis. However, long-term use of mouthwash containing broad-spectrum antibiotics can easily cause oral flora imbalance. As the frequency of use increases, the risk of developing drug-resistant bacteria and secondary infections increases. Long-term use of chlorhexidine-based mouthwash can easily cause tooth surface staining and taste changes, so it is not suitable for long-term use. It is also not accepted by patients because of its bitter taste, poor taste, and large local irritation. Some patients may even develop allergies and cause rashes. or stomatitis. The effective iodine content of iodine-containing mouthwash is unstable, and the effective content decreases quickly after dilution. It needs to be prepared immediately, which brings inconvenience to patients. Therefore, looking for mouthwashes that are natural, have few side effects, are effective, safe, alcohol-free, and can be used for a long time has become a new hot spot in the treatment of oral problems.
天然药物的应用历史悠久且毒副作用小，取材方便，经济实惠，有的还具有杀菌消炎作用，因而广泛用于基础研究及临床实践。中药制剂在口腔中的运用广泛，大量研究表明中药在治疗牙周病、口腔溃疡等疾病上具有良好的疗效。但目前对于该类中药的报道多为某种单一中草药的作用，对中药复方的研究较少，而中药复方更能体现中医辨证论治的特点，充分发挥药物的协同作用及中医药多种有效成分多靶点作用。Natural medicines have a long history of application and have few toxic and side effects. They are easy to obtain and economical. Some of them also have bactericidal and anti-inflammatory effects. Therefore, they are widely used in basic research and clinical practice. Traditional Chinese medicine preparations are widely used in the oral cavity. A large number of studies have shown that traditional Chinese medicine has good efficacy in treating periodontal disease, oral ulcers and other diseases. However, the current reports on this type of traditional Chinese medicine are mostly about the effects of a single Chinese herbal medicine, and there are fewer studies on compound Chinese medicine. Compound Chinese medicine can better reflect the characteristics of syndrome differentiation and treatment of traditional Chinese medicine, give full play to the synergistic effect of drugs and the many active ingredients of traditional Chinese medicine. target effect.
艾叶(拉丁名：Artemisia princeos)精油：艾叶精油分子渗透能力极强，易被皮肤迅速渗透吸收，进而调理气血、镇咳化痰、参与代谢，提升免疫力。艾叶辛苦温，具有止血、止痛、去虚火和寒火等功效。人体中的口腔溃疡、口腔炎、咽喉肿痛等病症都是由于体内虚火旺盛或者寒火旺盛导致的，艾叶精油对这些疾病都有很好的缓解作用。Mugwort leaf (Latin name: Artemisia princeos) essential oil: Mugwort leaf essential oil molecules have extremely strong penetrating ability and are easily absorbed by the skin, thereby regulating qi and blood, relieving cough and phlegm, participating in metabolism, and improving immunity. Mugwort leaves are pungent and warm, and have the effects of stopping bleeding, relieving pain, and removing deficiency fire and cold fire. Mouth ulcers, stomatitis, sore throat and other diseases in the human body are caused by strong deficiency fire or strong cold fire in the body. Mugwort essential oil has a good alleviation effect on these diseases.
仙鹤草(拉丁名：Agrimonia pilosa Ledeb)精油：仙鹤草精油有收敛止血，止痢杀虫等功效。可用于治疗牙龈出血、口腔发苦等口腔问题。Agrimony (Latin name: Agrimonia pilosa Ledeb) essential oil: Agrimonia essential oil has the effects of astringing and stopping bleeding, stopping dysentery and killing insects. It can be used to treat oral problems such as bleeding gums and sore mouth.
山苍子(拉丁名：Litsea cubeba)精油：山苍子精油对大部分微生物都具有很好的抗菌作用，对革兰氏阳性菌效果更好，另一方面能促进细胞再生，修护皮肤细胞组织，减轻炎症和肿胀的肌肤问题。Litsea cubeba (Latin name: Litsea cubeba) essential oil: Litsea cubeba essential oil has a good antibacterial effect on most microorganisms, and is more effective on Gram-positive bacteria. On the other hand, it can promote cell regeneration and repair skin cells. Tissue, reduce inflammation and swelling of skin problems.
发明内容Contents of the invention
本发明的发明目的是提供一种中药抑菌精油组合漱口液的配方及制备方法。本发明的中药抑菌精油漱口液全方配伍合理，组分间协同发挥作用，不仅可以有效抑菌、清洁口腔，还具有抑制牙龈出血、燥湿化痰的效果。此外，本发明制备工艺简单、适用群体广，孕妇儿童均可使用，无不良反应。The object of the present invention is to provide a formula and preparation method of a traditional Chinese medicine antibacterial essential oil combined mouthwash. The traditional Chinese medicine antibacterial essential oil mouthwash liquid of the present invention has a reasonable compatibility of all ingredients, and the components work synergistically. It can not only effectively inhibit bacteria and clean the oral cavity, but also has the effects of inhibiting gum bleeding, drying dampness and reducing phlegm. In addition, the preparation process of the present invention is simple and applicable to a wide range of groups, and can be used by pregnant women and children without any adverse reactions.
本发明提供的技术方案如下：The technical solutions provided by the invention are as follows:
一种抑制口腔细菌的中药精油漱口液，所述的山苍子精油、艾叶精油和仙鹤草精油的质量比为1-2∶1-2∶1-2。A traditional Chinese medicine essential oil mouthwash that inhibits oral bacteria. The mass ratio of Litsea cubeba essential oil, mugwort essential oil and Agrimony essential oil is 1-2:1-2:1-2.
优选地，所述的山苍子精油、艾叶精油和仙鹤草精油的质量比为1∶1∶1。Preferably, the mass ratio of Litsea cubeba essential oil, mugwort essential oil and Agrimony essential oil is 1:1:1.
本发明还提供了上述抑制口腔细菌的中药精油漱口液的制备方法，包括以下步骤：The invention also provides a method for preparing the above-mentioned traditional Chinese medicine essential oil mouthwash that inhibits oral bacteria, which includes the following steps:
将山苍子精油、艾叶精油、仙鹤草精油混合均匀，即制得抑制口腔细菌的中药精油漱口液。Mix Litsea cubeba essential oil, mugwort leaf essential oil and Agrimony essential oil evenly to prepare a traditional Chinese medicine essential oil mouthwash that inhibits oral bacteria.
本发明还保护了所述的中药复配精油在抑制口腔细菌、治疗牙周炎的应用，以及保持清洁口腔、抑制牙龈出血、燥湿化痰的应用。The invention also protects the application of the traditional Chinese medicine compound essential oil in inhibiting oral bacteria and treating periodontitis, as well as keeping the oral cavity clean, inhibiting gum bleeding, and drying dampness and reducing phlegm.
与现有技术相比，本发明具有的有益效果是：Compared with the prior art, the beneficial effects of the present invention are:
本发明技术方案使用天然的中药抑菌精油漱口液全方配伍合理，组分间协同作用，可显著减少口腔微生物的数量，包括牙龈卟啉单胞菌和金黄色葡萄球菌等，从而降低因牙龈卟啉单胞菌而引发的牙周炎以及因金黄色葡萄球菌、大肠杆菌和白色念球菌等造成的口腔溃疡和口角炎的发病率。本发明具有清洁口腔，抑制牙龈出血、燥湿化痰的效果。此外，本发明的中药复配精油制备工艺简单，有利于产业化的实现，且适用群体广，孕妇儿童均可使用，无不良反应。The technical solution of the present invention uses a natural Chinese medicine antibacterial essential oil mouthwash with reasonable compatibility, and the synergy between the components can significantly reduce the number of oral microorganisms, including Porphyromonas gingivalis and Staphylococcus aureus, etc., thereby reducing the risk of The incidence of periodontitis caused by Porphyromonas gingivalis and oral ulcers and angular stomatitis caused by Staphylococcus aureus, Escherichia coli and Candida albicans. The invention has the effects of cleaning the oral cavity, inhibiting gum bleeding, and removing dampness and reducing phlegm. In addition, the traditional Chinese medicine compound essential oil of the present invention has a simple preparation process, is conducive to the realization of industrialization, and has a wide range of applicable groups, and can be used by pregnant women and children without adverse reactions.
附图说明Description of drawings
图1为本发明等量的实施例1-7、对比例1-6制备的中药抑菌精油漱口液(0.5％)、甲硝唑含漱液(0.5％)及蒸馏水对照样品针对金黄色葡萄球菌测得的抑菌环直径对比图。除非特别说明，以上试样标本的含量除标注成分外其余为水。Figure 1 shows equal amounts of traditional Chinese medicine antibacterial essential oil mouthwash (0.5%), metronidazole gargle (0.5%) and distilled water control samples prepared in Examples 1-7 and Comparative Examples 1-6 of the present invention for golden yellow color. Comparison of inhibition zone diameters measured for Staphylococcus aureus. Unless otherwise specified, the content of the above sample specimens is water except for the ingredients marked.
图2为本发明等量的实施例1-7、对比例1-6制备的中药抑菌精油漱口液(0.5％)、甲硝唑含漱液(0.5％)及蒸馏水对照样品针对牙龈卟啉单胞菌测得的抑菌环直径对比图。Figure 2 shows equal amounts of traditional Chinese medicine antibacterial essential oil mouthwash (0.5%), metronidazole gargle (0.5%) and distilled water control samples prepared in Examples 1-7 and Comparative Examples 1-6 of the present invention against gingival porphyrin. Comparison of inhibition zone diameters measured for Chloromonas.
除非特别说明，图1与图2试样标本的含量除标注成分外其余为水。Unless otherwise specified, the content of the specimens in Figures 1 and 2 is water except for the ingredients indicated.
具体实施方式Detailed ways
实施例及对比例中的K-B纸片扩散体外抑菌法试验(即将含有定量药物的纸片贴在已接种待测菌的琼脂平板的特定区域，药物抑制细菌生长形成透明的抑菌环，来反映待测菌对药物的敏感程度)如下：The K-B paper disk diffusion in vitro antibacterial method test in the examples and comparative examples (that is, a paper disk containing a quantitative drug is attached to a specific area of an agar plate that has been inoculated with the bacteria to be tested, and the drug inhibits bacterial growth to form a transparent antibacterial ring. Reflecting the sensitivity of the bacteria to be tested to drugs) is as follows:
(1)将稀释1000倍后的麦氏浓度金黄色葡萄球菌菌液120μL均匀的涂布到备好的琼脂平板上，静置待菌液吸收。(1) Evenly spread 120 μL of Staphylococcus aureus liquid diluted 1000 times onto the prepared agar plate, and let it stand until the bacterial liquid is absorbed.
(2)将10片滤纸片置于玻璃平皿中；剧烈摇匀试样，迅速取样10μL滴加至滤纸，然后用无菌镊子将滤纸片贴在涂好菌液的琼脂表面上，轻压纸片，使其与琼脂适当接触，每平板贴三个纸片，平行三个平板，使各纸片间距相等。后于37℃培养箱培养24h后观察抑菌圈，然后用游标卡尺测量每一个抑菌圈直径，取平均值计数。(2) Place 10 pieces of filter paper in a glass dish; shake the sample vigorously, quickly sample 10 μL and drop it onto the filter paper, then use sterile tweezers to stick the filter paper piece on the agar surface coated with bacterial solution, and press the paper gently Make sure the pieces are in proper contact with the agar, stick three pieces of paper on each plate, and make the three plates parallel to each other so that the distance between the paper pieces is equal. After incubating in a 37°C incubator for 24 hours, the inhibition zones were observed, and then the diameter of each inhibition zone was measured with a vernier caliper, and the average value was calculated.
实施例及对比例中针对牙龈卟啉单胞菌做的抑菌试验：将厌氧血琼脂培养基在装有厌氧培养箱的洁净工作台操作，制备培养皿。在培养基中取牙龈卟啉单胞菌菌液50μL，用无菌涂布棒涂匀，待自然干燥后，用灭菌的打孔器在培养基上打孔，再在孔中分别滴入各实施例及对比例中准备的药液15μL。将培养基置于厌氧培养袋中，置于37℃培养箱中培养16h后观察抑菌圈直径并记录。每组药物平行重复3次，取平均值。Antibacterial test against Porphyromonas gingivalis in the Examples and Comparative Examples: The anaerobic blood agar culture medium was operated on a clean workbench equipped with an anaerobic incubator to prepare a petri dish. Take 50 μL of Porphyromonas gingivalis bacterial solution in the culture medium, spread it evenly with a sterile spreader stick, wait for natural drying, use a sterilized puncher to punch holes in the culture medium, and then drip into the holes respectively. The medicinal solution prepared in each Example and Comparative Example was 15 μL. Place the culture medium in an anaerobic culture bag and incubate it in a 37°C incubator for 16 hours. Then observe and record the diameter of the inhibition zone. Each group of drugs was repeated three times in parallel, and the average value was taken.
各实施例及对比例中中药抑菌精油漱口液的使用方法如下：取中药抑菌精油漱液0.1g，加清水稀释至20ml，剧烈振荡摇匀，先含3min再漱口。The method of using the traditional Chinese medicine antibacterial essential oil mouthwash in each of the examples and comparative examples is as follows: Take 0.1g of the traditional Chinese medicine antibacterial essential oil mouthwash, add water to dilute it to 20ml, shake vigorously and shake well, hold it for 3 minutes before gargling.
本发明的甲硝唑含漱液(云中莲甲硝唑含漱液，规格：0.5％)使用方法：含漱，一次20ml，先含3min再漱口。The method of using the metronidazole gargle of the present invention (Yunzhonglian metronidazole gargle, specification: 0.5%): gargle, 20 ml at a time, for 3 minutes before gargling.
按重量比称取山苍子精油、艾叶精油和仙鹤草精油，然后混合均匀，即制得抑制口腔细菌的中药精油漱口液。实施例与对比例配方如表1所示：Weigh Litsea cubeba essential oil, mugwort leaf essential oil and Agrimony essential oil according to weight ratio, and then mix them evenly to prepare a traditional Chinese medicine essential oil mouthwash that inhibits oral bacteria. The formulas of Examples and Comparative Examples are shown in Table 1:
表1各实施例、对比例配方(重量份)Table 1 Examples and comparative example formulas (parts by weight)
中药抑菌精油漱口液的性能测试Performance test of traditional Chinese medicine antibacterial essential oil mouthwash
(一)口感及气味测试(1) Taste and smell test
选取患有口腔溃疡、牙龈出血等口腔问题的患者60名，男女各半，平均年龄35周岁。以本发明的实施例1-7为测试组，以云中莲甲硝唑含漱液为对照组。结果如表2所示：60 patients with oral problems such as oral ulcers and bleeding gums were selected, half of them male and female, with an average age of 35 years old. Examples 1-7 of the present invention were used as the test group, and Yunzhonglian Metronidazole Gargle was used as the control group. The results are shown in Table 2:
表2口感及气味测试结果Table 2 Taste and odor test results
表2所示本实施例1-7(山苍子精油、艾叶精油、仙鹤草精油混合均匀制得的中药抑菌精油漱口液)及甲硝唑含漱液针对口感及气味的测试，结果显示本发明的实施例1-7清爽无刺激、气味宜人、顺应性强，而甲硝唑含漱液味道苦，患者难以接受，给治疗造成阻碍。Table 2 shows the test results of Examples 1-7 (traditional Chinese medicine antibacterial essential oil mouthwash prepared by uniformly mixing Litsea cubeba essential oil, mugwort essential oil, and Agrimony essential oil) and metronidazole rinse for taste and smell. It is shown that Examples 1-7 of the present invention are refreshing and non-irritating, have pleasant smell, and have strong compliance, while the metronidazole gargle has a bitter taste, which is difficult for patients to accept and hinders treatment.
(二)长期使用效果测试(2) Long-term use effect test
选取患有口腔溃疡、牙龈出血等口腔问题的患者300名，男女各半，平均年龄35周岁。随机分为15组，每组20人。300 patients with oral problems such as oral ulcers and bleeding gums were selected. They were equally divided between men and women, with an average age of 35 years old. Randomly divided into 15 groups, with 20 people in each group.
患者分别使用等量(20mI)实施例1-7、对比例1-6制备得到的中药抑菌精油漱口液、甲硝唑含漱液、蒸馏水，含漱，先含3min再漱口。一日早中晚饭后漱口三次，连续2星期。The patient used equal amounts (20 ml) of the traditional Chinese medicine antibacterial essential oil mouthwash, metronidazole gargle, and distilled water prepared in Examples 1-7 and Comparative Examples 1-6, respectively, to gargle for 3 minutes before gargling. Rinse your mouth three times a day after breakfast, lunch and dinner for 2 weeks.
疗效标准：明显改善：口腔问题如口腔溃疡、牙龈出血、口腔异臭明显改善或消失。改善：口腔问题得到一定程度的改善，但不明显。无效：口腔问题未得到改善。恶化：口腔问题进一步恶化。Efficacy standard: significant improvement: Oral problems such as oral ulcers, gum bleeding, and oral odor are significantly improved or disappeared. Improvement: Oral problems have been improved to a certain extent, but not significantly. Ineffective: Oral problems are not improved. Exacerbation: Oral problems worsen.
结果如表3所示：The results are shown in Table 3:
表3长期使用效果测试结果Table 3 Long-term use effect test results
表3所示本发明实施例1-7、对比例1-6一日早中晚饭后漱口三次，连续使用2星期的效果测试。比较实施例1-7，结果显示，实施例3的使用效果最好，即当山苍子精油、艾叶精油和仙鹤草精油的质量比为1∶1∶1时口腔问题得到最大程度的改善。比较实施例7和对比例1-6，使用效果的排序为(从优到劣)实施例7＞对比例1＞对比例3＞对比例2＞对比例6＞对比例5＞对比例4，此使用效果排序说明本发明的中药抑菌精油漱口液全方配伍合理，仙鹤草精油、艾叶精油和山苍子精油可发生协同作用，比单独使用某种精油或单独使用任意两种精油效果更好，其疗效也更为显著。此外，从表2也可看出，实施例1-7、对比例1-6的使用效果也都比甲硝唑含漱液更好。Table 3 shows the effect test of Examples 1-7 and Comparative Examples 1-6 of the present invention by gargling three times a day after breakfast, lunch and dinner, and using them continuously for 2 weeks. Comparing Examples 1-7, the results show that Example 3 has the best use effect, that is, when the mass ratio of Litsea cubeba essential oil, mugwort essential oil and Agrimony essential oil is 1:1:1, oral problems are improved to the greatest extent. Comparing Example 7 and Comparative Examples 1-6, the ranking of the use effects is (from best to worst) Example 7>Comparative Example 1>Comparative Example 3>Comparative Example 2>Comparative Example 6>Comparative Example 5>Comparative Example 4, here The ranking of the use effects shows that the traditional Chinese medicine antibacterial essential oil mouthwash of the present invention has a reasonable compatibility of all ingredients. Agrimony essential oil, mugwort essential oil and litsea cubeba essential oil can have a synergistic effect, which is more effective than using a certain essential oil alone or using any two essential oils alone. Well, its curative effect is also more significant. In addition, it can also be seen from Table 2 that the use effects of Examples 1-7 and Comparative Examples 1-6 are better than those of metronidazole rinse.
图1所示本发明等量的实施例1-7、对比例1-6制备的中药抑菌精油漱口液(0.5％)、甲硝唑含漱液(0.5％)及蒸馏水对照样品针对金黄色葡萄球菌测得的抑菌环直径对比图。从图1可知，抑菌效果：实施例7＞实施例3＞实施例2＞实施例4＞实施例1＞实施例6＞实施例5＞对比例2＞甲硝唑含漱液＞对比例1＞对比例3＞对比例4＞对比例5＞对比例6＞蒸馏水，说明当山苍子精油、艾叶精油和仙鹤草精油的质量比为1∶1∶1时，对金黄色葡萄球菌的抑菌效果最为显著，且山苍子精油、艾叶精油和仙鹤草精油可协同发挥作用，比单独使用某种精油或单独使用任意两种精油对金黄色葡萄球菌的抑菌效果更好。Figure 1 shows equal amounts of traditional Chinese medicine antibacterial essential oil mouthwash (0.5%), metronidazole gargle (0.5%) and distilled water control samples prepared in Examples 1-7 and Comparative Examples 1-6 of the present invention against gold. Comparison of the inhibition zone diameters measured for Staphylococcus aureus. As can be seen from Figure 1, the antibacterial effect is: Example 7>Example 3>Example 2>Example 4>Example 1>Example 6>Example 5>Comparative Example 2>Metronidazole Gargle>Comparative Example 1> Comparative Example 3> Comparative Example 4> Comparative Example 5> Comparative Example 6> Distilled water, indicating that when the mass ratio of Litsea cubeba essential oil, mugwort essential oil and Agrimony essential oil is 1:1:1, the inhibitory effect on Staphylococcus aureus is The antibacterial effect is the most significant, and Litsea cubeba essential oil, mugwort essential oil and Agrimony essential oil can work synergistically, and have a better antibacterial effect on Staphylococcus aureus than using a certain essential oil alone or using any two essential oils alone.
图2所示本发明等量的实施例1-7、对比例1-6制备的中药抑菌精油漱口液(0.5％)、甲硝唑含漱液(0.5％)及蒸馏水对照样品针对牙龈卟啉单胞菌测得的抑菌环直径对比图。从图2可知，抑菌效果：实施例7＞实施例5＞实施例6＞实施例2＞实施例1＞实施例3＞甲硝唑含漱液＞对比例1＞对比例3＞对比例4＞对比例2＞对比例5＞对比例6＞蒸馏水，说明当山苍子精油、艾叶精油和仙鹤草精油的质量比为1∶1∶1时，对牙龈卟啉单胞菌的抑菌效果最为显著，且山苍子精油、艾叶精油和仙鹤草精油可协同发挥作用，比单独使用某种精油或单独使用任意两种精油对金黄色葡萄球菌的抑菌效果更好。Figure 2 shows equal amounts of traditional Chinese medicine antibacterial essential oil mouthwash (0.5%), metronidazole gargle (0.5%) and distilled water control samples prepared in Examples 1-7 and Comparative Examples 1-6 of the present invention for gingivitis. Comparison of the inhibition zone diameters measured for Porphyromonas. As can be seen from Figure 2, the antibacterial effect is: Example 7>Example 5>Example 6>Example 2>Example 1>Example 3>Metronidazole Gargle>Comparative Example 1>Comparative Example 3>Comparative Example 4> Comparative Example 2> Comparative Example 5> Comparative Example 6> Distilled water, illustrates the antibacterial effect on Porphyromonas gingivalis when the mass ratio of Litsea cubeba essential oil, mugwort essential oil and Agrimony essential oil is 1:1:1 The most significant, and Litsea cubeba essential oil, mugwort essential oil and Agrimony essential oil can work synergistically, and have a better antibacterial effect on Staphylococcus aureus than using a certain essential oil alone or using any two essential oils alone.
以上所述，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，根据本发明的技术方案及其发明构思加以等同替换或改变，都应涵盖在本发明的保护范围之内。The above are only preferred specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto. Any person familiar with the technical field can, within the technical scope disclosed in the present invention, implement the technical solutions of the present invention. Equivalent substitutions or changes of the inventive concept thereof shall be included in the protection scope of the present invention.
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|---|---|---|---|---|
| CN102397176A (en) * | 2010-09-17 | 2012-04-04 | 南京星银药业集团有限公司 | A Chinese medicinal collutory and its preparation method |
| CN103536497A (en) * | 2013-10-30 | 2014-01-29 | 昆明理工大学 | Traditional Chinese medicinal compound collutory and preparation method thereof |
| WO2017206015A1 (en) * | 2016-05-30 | 2017-12-07 | 江苏奇力康皮肤药业有限公司 | Long-lasting antibacterial and tooth protection gargle |
| CN113081900A (en) * | 2021-04-06 | 2021-07-09 | 河北科技大学 | Gargle and preparation method and application thereof |
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2022
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397176A (en) * | 2010-09-17 | 2012-04-04 | 南京星银药业集团有限公司 | A Chinese medicinal collutory and its preparation method |
| CN103536497A (en) * | 2013-10-30 | 2014-01-29 | 昆明理工大学 | Traditional Chinese medicinal compound collutory and preparation method thereof |
| WO2017206015A1 (en) * | 2016-05-30 | 2017-12-07 | 江苏奇力康皮肤药业有限公司 | Long-lasting antibacterial and tooth protection gargle |
| CN113081900A (en) * | 2021-04-06 | 2021-07-09 | 河北科技大学 | Gargle and preparation method and application thereof |
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