CN108686023A - A kind of antipruritic moisturizing essential oil for treating geroderma itch - Google Patents

Abstract

The object of the present invention is to provide an antipruritic emollient essential oil for treating senile skin itching, which is made by mixing the following medicines: 2-4ml of Zanthoxylum bungeanum essential oil, 2-4ml of Artemisia argyi essential oil, 2-4ml of licorice essential oil, Kochia chinensis Essential oil 1.5‑2.5ml, Sophora flavescens essential oil 1.5‑2.5ml, Angelica essential oil 1.5‑2.5ml, Trichosanthes essential oil 1.5‑2.5ml, Perilla essential oil 1.5‑2.5ml, Peppermint essential oil 1.5‑2.5ml and borneol 2‑3g; The invented formula is scientific and reasonable, rich in raw materials, easy to produce and prepare, has the effect of disinfecting, relieving itching, and moisturizing the skin, and is effective for treating senile skin itching, with good curative effect and safe medication. Good economic and social benefits.

Description

An antipruritic emollient essential oil for treating senile skin itching

technical field

The invention relates to traditional Chinese medicine, in particular to an antipruritic and emollient essential oil for treating senile skin pruritus.

Background technique

Senile pruritus is a common clinical disease, especially in the dry and cold northwest region, the incidence of the disease is very high. Skin pruritus belongs to the category of "itch wind" and "wind pruritus" in traditional Chinese medicine. Pruritus is a disease with pruritus as the main symptom and no primary skin lesions, which is difficult for patients to tolerate, and clinical symptoms such as secondary scratches, pigmentation, and blood crusts may appear after repeated scratching. The disease is difficult to cure completely, and it is easy to recur, which affects the quality of life of patients. Although chemical drug therapy has a certain effect, it is often accompanied by adverse reactions such as drowsiness and fatigue, which have an impact on work and life. Although there are many drugs for the treatment of senile skin itching, the therapeutic effect is not satisfactory due to various reasons. Therefore, improvement and innovation in its medicine is imperative.

Contents of the invention

In view of the above situation, in order to overcome the defects of the prior art, the object of the present invention is to provide an antipruritic emollient essential oil for treating senile skin itching, which can effectively solve the problem of medication for treating senile skin itching.

The technical scheme solved by the present invention is that an antipruritic emollient essential oil for treating senile skin itching is prepared by mixing the following medicines: 2-4ml of pepper essential oil, 2-4ml of mugwort essential oil, 2-4ml of licorice essential oil, ground Fuzi essential oil 1.5-2.5ml, Sophora flavescens essential oil 1.5-2.5ml, Angelica dahurica essential oil 1.5-2.5ml, Trichosanthes essential oil 1.5-2.5ml, Perilla essential oil 1.5-2.5ml, Peppermint essential oil 1.5-2.5ml and borneol 2-3g ;

The described Zanthoxylum bungeanum essential oil is that Zanthoxylum bungeanum is pulverized into coarse powder passing through a 10-20 mesh sieve, extracted with supercritical _CO2 fluid, and the weight-to-volume ratio of material to liquid is 1:10-20, and the weight-to-volume ratio refers to solid in g, liquid In mL, the extraction temperature is 42-50°C, the extraction pressure is 20-25MPa, the separation temperature is 50-60°C, the separation pressure is 4.5-5.5MPa, the extraction time is 1.5-2.5h, and the pepper essential oil is obtained;

The described Artemisia argyi essential oil is that Artemisia argyi is crushed into a coarse powder passing through a 10-20 mesh sieve, extracted with supercritical _CO2 fluid, and the weight-to-volume ratio of material to liquid is 1:10-20, and the weight-to-volume ratio refers to solid in g, liquid In mL, the extraction temperature is 42-50°C, the extraction pressure is 20-25MPa, the separation temperature is 50-60°C, the separation pressure is 4.5-5.5MPa, and the extraction time is 1.5-2.5h, to obtain Artemisia argyi essential oil;

The licorice essential oil is that the licorice is crushed into coarse powder passing through a 10-20 mesh sieve, extracted with supercritical _CO2 fluid, and the weight-to-volume ratio of material to liquid is 1:10-20. The weight-to-volume ratio refers to the solid in g and the liquid In mL, the extraction temperature is 42-50°C, the extraction pressure is 20-25MPa, the separation temperature is 50-60°C, the separation pressure is 4.5-5.5MPa, the extraction time is 1.5-2.5h, and the licorice essential oil is obtained;

The Kochia scoparia essential oil is that the Kochia scopariae is crushed into coarse powder passing through a 10-20 mesh sieve, extracted with supercritical _CO2 fluid, and the weight-to-volume ratio of material to liquid is 1:10-20, and the weight-to-volume ratio refers to solid to In g, liquid in mL, extraction temperature 42-50°C, extraction pressure 20-25MPa, separation temperature 50-60°C, separation pressure 4.5-5.5MPa, extraction time 1.5-2.5h, to obtain Kochia scoparia essential oil;

The described Sophora flavescens essential oil is that Sophora flavescens is crushed into coarse powder passing through a 10-20 mesh sieve, extracted with supercritical _CO2 fluid, and the weight-to-volume ratio of material to liquid is 1:10-20, and the weight-to-volume ratio refers to the solid in g , the liquid is measured in mL, the extraction temperature is 42-50°C, the extraction pressure is 20-25MPa, the separation temperature is 50-60°C, the separation pressure is 4.5-5.5MPa, and the extraction time is 1.5-2.5h to obtain Sophora flavescens essential oil;

The described Angelica dahurica essential oil is that the Angelica dahurica is crushed into a coarse powder passing through a 10-20 mesh sieve, extracted with supercritical _CO2 fluid, and the weight-to-volume ratio of material to liquid is 1:10-20, and the weight-to-volume ratio refers to the solid in g, and the liquid In mL, the extraction temperature is 42-50°C, the extraction pressure is 20-25MPa, the separation temperature is 50-60°C, the separation pressure is 4.5-5.5MPa, the extraction time is 1.5-2.5h, and the essential oil of Angelica dahurica is obtained;

Described trichosanthes essential oil is that trichosanthes is pulverized into the coarse powder of passing through 10～20 mesh sieves, supercritical CO ₂ fluid extraction, material-liquid weight-volume ratio 1:10～20, and weight-volume ratio refers to the solid in g , the liquid is measured in mL, the extraction temperature is 42-50°C, the extraction pressure is 20-25MPa, the separation temperature is 50-60°C, the separation pressure is 4.5-5.5MPa, the extraction time is 1.5-2.5h, and the Trichosanthes essential oil is obtained;

The perilla essential oil is that perilla is crushed into a coarse powder passing through a 10-20 mesh sieve, extracted with supercritical _CO2 fluid, and the weight-to-volume ratio of material to liquid is 1:10-20, and the weight-to-volume ratio refers to the solid in g , the liquid is measured in mL, the extraction temperature is 42-50°C, the extraction pressure is 20-25MPa, the separation temperature is 50-60°C, the separation pressure is 4.5-5.5MPa, the extraction time is 1.5-2.5h, and perilla essential oil is obtained;

The peppermint essential oil is as follows: mint is crushed into a coarse powder passing through a 10-20 mesh sieve, extracted with supercritical _CO2 fluid, the weight-to-volume ratio of material to liquid is 1:10-20, and the weight-to-volume ratio refers to the solid in g, the liquid In mL, the extraction temperature is 42-50°C, the extraction pressure is 20-25MPa, the separation temperature is 50-60°C, the separation pressure is 4.5-5.5MPa, and the extraction time is 1.5-2.5h to obtain peppermint essential oil.

The prescription of the present invention is scientific and reasonable, has abundant raw materials, is easy to produce and prepare, has the effects of disinfecting, relieving itching, and moisturizing the skin, and is effectively used for treating senile skin itching, with good curative effect and safe medication, and is an innovation in medicine for treating senile skin itching. There are good economic and social benefits.

Detailed ways

The specific implementation of the present invention will be described in detail below in combination with specific conditions and examples.

Specific embodiments of the present invention can be given by the following examples.

Embodiment 1: A kind of antipruritic emollient essential oil for treating senile skin pruritus of the present invention is made by mixing the following medicines: 3ml of Zanthoxylum bungeanum essential oil, 3ml of Artemisia argyi essential oil, 3ml of licorice essential oil, 2ml of Kochia scoparia essential oil, Sophora flavescens essential oil 2ml, Angelica essential oil 2ml, Trichosanthes essential oil 2ml, perilla essential oil 2ml, peppermint essential oil 2ml and borneol 3g.

Embodiment 2: A kind of antipruritic emollient essential oil for treating senile skin pruritus of the present invention is made by mixing the following medicines: 2ml of Zanthoxylum bungeanum essential oil, 2ml of Artemisia argyi essential oil, 2ml of licorice essential oil, 1.5ml of Kochia scoparia essential oil, Sophora flavescens Essential oil 1.5ml, Angelica essential oil 1.5ml, Trichosanthes essential oil 1.5ml, Perilla essential oil 1.5ml, Peppermint essential oil 1.5ml and borneol 2g.

Embodiment 3: A kind of antipruritic emollient essential oil for treating senile skin pruritus of the present invention is made by mixing the following medicines: 4ml of Zanthoxylum bungeanum essential oil, 4ml of Artemisia argyi essential oil, 4ml of licorice essential oil, 2.5ml of Kochia scoparia essential oil, Sophora flavescens Essential oil 2.5ml, Angelica essential oil 2.5ml, Trichosanthes essential oil 2.5ml, Perilla essential oil 2.5ml, Peppermint essential oil 2.5ml and borneol 3g.

Embodiment 4: A kind of antipruritic emollient essential oil for treating senile skin pruritus of the present invention is made by mixing the following medicines: 2ml of Zanthoxylum bungeanum essential oil, 4ml of Artemisia argyi essential oil, 2ml of licorice essential oil, 2.5ml of Kochia scoparia essential oil, Sophora flavescens Essential oil 1.5ml, Angelica essential oil 2.5ml, Trichosanthes essential oil 1.5ml, Perilla essential oil 2.5ml, Peppermint essential oil 1.5ml and borneol 3g.

Embodiment 5: A kind of antipruritic emollient essential oil for treating senile skin pruritus of the present invention is made by mixing the following medicines: 4ml of Zanthoxylum bungeanum essential oil, 2ml of Artemisia argyi essential oil, 4ml of licorice essential oil, 1.5ml of Kochia scoparia essential oil, Sophora flavescens Essential oil 2.5ml, Angelica essential oil 1.5ml, Trichosanthes essential oil 2.5ml, Perilla essential oil 1.5ml, Peppermint essential oil 2.5ml and borneol 2g.

The present invention has obtained very good effect through test and field application: relevant test data are as follows:

1. Animal test:

1 Experimental materials

1.1 Experimental equipment:

FA(N)/JA(N) series electronic balance, Shanghai Minqiao Precision Instrument Co., Ltd.;

1.2 Experimental reagents:

The antipruritic and emollient essential oil of the present invention. Fudean is produced by Shenyang Kangshi Pharmaceutical and Health Products Co., Ltd. Hair removal cream, produced by Shanghai Shibi Cosmetics Co., Ltd. Sodium chloride injection was produced by Shandong Hualu Pharmaceutical Co., Ltd. Dextran, produced by Beijing Suolaibao Technology Co., Ltd.

1.3 Experimental animals

20-22g KM mice, half male and half female, SPF grade, quality certificate No. 37009200007439, Shandong Provincial Experimental Animal Center license number SCXK Lu 20140007. The experimental unit uses the license number SYXK (Yu) 2015-0005.

2 Experimental methods

2.1 Animal feeding

The temperature was 22-26°C, the humidity was 40-60%, the artificial lighting was 12 hours day and 12 hours night alternately, and a normal laboratory diet was given without restriction on drinking water.

2.2 Experimental method

Take 48 KM mice, half male and half male, and randomly divide them into 4 groups, 12 mice in each group, that is, the model group, the Fudean group, and the large and small dose antipruritic and emollient essential oil groups. 1 d before the administration, the hair of the abdominal skin of the mouse was removed for subsequent use, and then the skin of the depilated place was smeared for administration, and the model group was applied with 0.9% sodium chloride injection (0.3ml, divided into two times, 0.15ml each time). Small dose antipruritic emollient essential oil group (0.3ml of the original essential oil and one-fold dilution of essential oil with liquid paraffin, applied twice, 0.15ml each time), Fude'an ointment 0.3g (thickness: 2mm). 30min (all groups are painted once, 15min and then again). Then mice in each group were injected with 0.025% dextran 5 mL·kg-1 (1.25 mg·kg-1) through the tail vein to obtain a mouse pruritus model. Scratching the head with front paws, scratching the trunk with hind paws, and biting various parts of the whole body were used as indications of itching.

The itching latency period (the time from the end of the injection to the start of the first scratching) and the number of itching of the mice within 30 min after the first scratching were recorded. Scratching the injection site with the mouse's hind limbs until it stopped was counted as 1 scratch (continuous scratching was counted as 1 time). Times of itching: since the first scratching action of the pruritus model mice, record the total number of times of scratching within 30 minutes.

2.3 Statistical methods

The experimental data was processed with SPSS21 statistical software, and the data was The t test was used for comparison between groups.

3 Experimental results

Table 1 The effect of traditional Chinese medicine Zhiyang prescription on the pruritus model in mice

Note: **P<0.01, *P<0.05, compared with the model group

It can be seen from the above table that compared with the model group, the large and small doses of antipruritic emollient essential oil group and Fudean group can significantly prolong the time of the first itching in mice (P<0.01), and significantly reduce the number of itching in mice (P<0.01). <0.01).

2. The effect on guinea pig pruritus model

1 Experimental materials

1.1 Experimental equipment:

FA(N)/JA(N) series electronic balance, Shanghai Minqiao Precision Instrument Co., Ltd.;

1.2 Experimental reagents:

Essential oil of the present invention. Fudean is produced by Shenyang Kangshi Pharmaceutical and Health Products Co., Ltd. Hair removal cream, produced by Shanghai Shibi Cosmetics Co., Ltd. Sodium chloride injection was produced by Shandong Hualu Pharmaceutical Co., Ltd. Histamine phosphate, produced by Yuanye Biotechnology Co., Ltd.

1.3 Experimental animals

Guinea pigs, body weight 250-280g, half male and half male, normal grade, quality certificate of Shandong Experimental Animal Center: NO.37009200000334, license number: SCXK Lu 20140007. Experimental unit use license number: SYXK (Yu) 2015-0005.

2 Experimental methods

2.1 Animal feeding:

The temperature was 22-26°C, the humidity was 40-60%, the artificial lighting was 12 hours day and 12 hours night alternately, and a normal laboratory diet was given without restriction on drinking water.

2.2 Experimental method

Take 48 healthy guinea pigs, half male and half male, 250-280g. They were randomly divided into 4 groups, 12 rats in each group, namely: model group, Fudean group, large and small dose antipruritic emollient essential oil groups. After 24 hours of depilation of the animal's right hind foot, the drug was administered to the depilated part of the right hind foot of each guinea pig respectively. In the large and small doses of antipruritic and emollient essential oil group (0.15ml of the original essential oil and one-fold dilution of essential oil with liquid paraffin), Fudean 0.3 g of Fude'an Ointment (thickness: 2 mm) was applied in the model group, and 0.3 mL of 0.9% sodium chloride injection was applied in the model group. Keep it for 15min. After 15 minutes, rub the local area with gauze until there is bleeding point (the degree of bleeding and no obvious bleeding), with an area of 1 cm ² , and then give the corresponding drug once in the same way, and start 10 minutes after the administration, respectively on the wound surface Apply 50 μL of 0.01% histamine phosphate, and then drop the same amount of histamine phosphate every 3 minutes on the same part in order to increase the concentration to 0.02%, 0.03%, 0.04%, until the guinea pig turns back and licks the foot, during this period of time The total amount of histamine phosphate dripped to each animal is the itching threshold. If the guinea pig has not licked the hind feet after dripping to 0.1% histamine phosphate, the total amount of the dropping is the itching threshold, and the itching threshold of each group is compared. .

2.3 Statistical methods

The experimental data was processed with SPSS21 statistical software, and the data was The t test was used for comparison between groups.

3 Experimental results

Table 2 The effect of traditional Chinese medicine Zhiyang prescription on guinea pig pruritus model

Note: **P<0.01, compared with the model group

It can be seen from the above table that compared with the model group, both the large and small doses of antipruritic emollient essential oil group and Fudean group can significantly increase the itching domain of guinea pigs (P<0.01).

2. Clinical trials:

On the basis of ensuring the safety of animal experiments, it has also achieved very satisfactory beneficial technical effects through clinical trials. The relevant information is as follows:

1. Criteria for selecting cases:

Senile pruritus is a common clinical disease, especially in the dry and cold northwest region, the incidence of the disease is very high. Skin pruritus belongs to the category of "itch wind" and "wind pruritus" in traditional Chinese medicine. Pruritus is a disease with pruritus as the main symptom and no primary skin lesions, which is difficult for patients to tolerate, and clinical symptoms such as secondary scratches, pigmentation, and blood crusts may appear after repeated scratching. Those who have the above symptoms are used as the criteria for selecting cases.

2. Diagnostic criteria:

All have above-mentioned symptoms, can be diagnosed as suffering from senile pruritus through diagnostic test, and give medicine treatment of the present invention.

3. Treatment plan:

Adopt the present invention's medicine treatment to the patient of diagnosis, every day twice, each once sooner or later, be applied to affected part, continuous two weeks is a course for the treatment of, and establish control group while test, control group is oral cetirizine, 10mg/time, Once a day. During the treatment period, the two groups adjusted their diet reasonably, reduced the number of baths, banned alkaline soap, and wore loose cotton clothes.

4. Criteria for evaluation of curative effect:

The degree of curative effect was scored by visual analog scale (VAS) to evaluate the degree of itching in the two groups, (1-3) was divided into mild, (4-6) was divided into moderate, (7-10 was divided into severe.

Judgment of curative effect Graded and scored the degree of itching, frequency of occurrence, duration, and area of itching, with 0 being none, 5 being mild, 10 being moderate, and 15 being severe. The total scores before and after treatment were counted. Curative effect index=(total score before treatment-total score after treatment)/total score before treatment×100%. Curative effect index ≥ 95% is cured; 70% ≤ curative index < 95% is markedly effective; 30% ≤ curative index < 70% is effective; curative index < 30% is ineffective. Total effective rate=(cured+markedly effective+effective)/total number of cases×100%.

5. Statistical processing:

The 56 patients who were diagnosed were randomly divided into the present invention group and the control group, each with 28 cases, wherein, the degree of itching: 28 cases in the present invention, the VAS score before treatment was 7.8 ± 1.6, and 2.1 ± 0.9 after treatment; 28 cases in the control group , the VAS score was 7.7±1.5 before treatment and 3.9±1.2 after treatment.

In the present invention group of 28 cases, 9 cases (32.1%) were cured, 13 cases (46.4%) were markedly effective, 4 cases (14.3%) were effective, 2 cases (7.1%) were ineffective, and the total effective rate was 92.9%. Of the 28 cases in the control group, 2 cases (7.1%) were cured, 10 cases (35.7%) were markedly effective, 8 cases (28.6%) were effective, and 8 cases (28.6%) were ineffective, and the total effective rate was 71.4%. And during the test, no adverse reactions and side effects were found.

6. Conclusion: It can be seen from the above that the prescription of the present invention is scientific and reasonable, rich in raw materials, easy to produce and prepare, has the effect of disinfecting and relieving itching, and moisturizing the skin, and is effective for treating senile skin itching, with good curative effect, and the curative effect is as high as 92%. Above, the curative effect is stable and reliable, and the medication is safe. It is an innovation in the treatment of senile skin pruritus, and has good economic and social benefits.

Claims (6)

1. An antipruritic emollient essential oil for the treatment of senile skin pruritus, characterized in that: it is made by mixing the following medicines: 2-4ml of Zanthoxylum bungeanum essential oil, 2-4ml of Artemisia argyi essential oil, 2-4ml of licorice essential oil, Kochia scoparia Essential oil 1.5-2.5ml, Sophora flavescens essential oil 1.5-2.5ml, Angelica essential oil 1.5-2.5ml, Trichosanthes essential oil 1.5-2.5ml, Perilla essential oil 1.5-2.5ml, Peppermint essential oil 1.5-2.5ml and borneol 2-3g; The described Zanthoxylum bungeanum essential oil is that Zanthoxylum bungeanum is pulverized into coarse powder passing through a 10-20 mesh sieve, extracted with supercritical _CO2 fluid, and the weight-to-volume ratio of material to liquid is 1:10-20, and the weight-to-volume ratio refers to solid in g, liquid In mL, the extraction temperature is 42-50°C, the extraction pressure is 20-25MPa, the separation temperature is 50-60°C, the separation pressure is 4.5-5.5MPa, the extraction time is 1.5-2.5h, and the pepper essential oil is obtained; The preparation methods of the Artemisia argyi essential oil, licorice essential oil, Kochia scoparia essential oil, Sophora flavescens essential oil, Angelica dahurica essential oil, Trichosanthes quince essential oil, perilla essential oil and peppermint essential oil are the same as that of Zanthoxylum bungeanum essential oil. 2. The antipruritic and emollient essential oil for treating senile skin pruritus according to claim 1 is characterized in that: it is made by mixing the following medicines: 3ml of Zanthoxylum bungeanum essential oil, 3ml of Artemisia argyi essential oil, 3ml of licorice essential oil, Kochia scoparia essential oil 2ml, Sophora flavescens essential oil 2ml, Angelica dahurica essential oil 2ml, Trichosanthes essential oil 2ml, perilla essential oil 2ml, peppermint essential oil 2ml and borneol 3g. 3. the antipruritic emollient essential oil for the treatment of senile skin pruritus according to claim 1, is characterized in that: Mix well to make: 2ml of pepper essential oil, 2ml of mugwort essential oil, 2ml of licorice essential oil, 1.5ml of Kochia essential oil, 1.5ml of Sophora flavescens essential oil, 1.5ml of Angelica dahurica essential oil, 1.5ml of Trichosanthes essential oil, 1.5ml of Perilla essential oil, 1.5ml of Peppermint essential oil ml and borneol 2g. 4. the antipruritic emollient essential oil for the treatment of senile skin pruritus according to claim 1, is characterized in that: it is made of following medicine Mix well to make: 4ml of pepper essential oil, 4ml of mugwort essential oil, 4ml of licorice essential oil, 2.5ml of Kochia essential oil, 2.5ml of Sophora flavescens essential oil, 2.5ml of Angelica dahurica essential oil, 2.5ml of Trichosanthes essential oil, 2.5ml of Perilla essential oil, 2.5ml of Peppermint essential oil ml and borneol 3g. 5. the antipruritic emollient essential oil for the treatment of senile skin pruritus according to claim 1, is characterized in that: it is made of following medicine Mix well to make: 2ml of pepper essential oil, 4ml of mugwort essential oil, 2ml of licorice essential oil, 2.5ml of Kochia scoparia essential oil, 1.5ml of Sophora flavescens essential oil, 2.5ml of Angelica dahurica essential oil, 1.5ml of Trichosanthes essential oil, 2.5ml of perilla essential oil, 1.5ml of peppermint essential oil ml and borneol 3g. 6. the antipruritic emollient essential oil for the treatment of senile skin pruritus according to claim 1, is characterized in that: it is made of following medicine Mix well to make: 4ml of pepper essential oil, 2ml of mugwort essential oil, 4ml of licorice essential oil, 1.5ml of Kochia essential oil, 2.5ml of Sophora flavescens essential oil, 1.5ml of Angelica dahurica essential oil, 2.5ml of Trichosanthes essential oil, 1.5ml of perilla essential oil, 2.5ml of peppermint essential oil ml and borneol 2g.