CN108553589A - Capsule with dendrobium stem and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of capsule with dendrobium stem and preparation method thereof, the content of capsule consists of the following compositions by weight：40~60 parts of stem of Dendrobium, 45~55 parts of Herba Cistanches, 40~55 parts of the fruit of Chinese wolfberry, 45~55 parts of ripe dried rehamnnia root, 40~60 parts of Radix Polygalae, 40~55 parts of Semen Cuscutae, 40~55 parts of teasel root and day 1~3 part of hero.The capsule with dendrobium stem of the present invention has effects that anti-oxidant, raising immunity and inhibits tumour by the coordinative role of each raw material.

Description

Dendrobium capsule and preparation method thereof

technical field

The invention relates to a medicine and health product, in particular to a dendrobium capsule and a preparation method thereof.

Background technique

Dendrobium is the fresh or dry stem of the cultivated product of Dendrobium nobile Lindl., Dendrobium chrysotoxum Lindl. or Dendrobium fimbriatum Hook. of the Orchidaceae plant and similar species of plants of the same genus. Chinese medicinal materials. Dendrobium contains polysaccharides, alkaloids, amino acids, trace elements and phenanthrene compounds and other active ingredients, which have the functions of improving immunity, anti-tumor, anti-oxidation, anti-aging, inhibiting platelet aggregation, dilating blood vessels, promoting secretion of digestive juice, reducing blood fat, It has a wide range of pharmacological effects such as lowering blood sugar, reducing fever and relieving pain, and its miraculous efficacy has received more and more attention and attention.

Regarding the Dendrobium health care product, Chinese patent document CN106309933A (application number 201510337553.0) discloses a health product of Dendrobium candidum that is anti-fatigue, improves immunity, relieves alcohol and detoxifies, and consists of 40-60 parts of Dendrobium candidum, 15-30 parts of Hovenia dulcis, 15- 20 parts of kudzu root, 5-10 parts of pearl powder, and 5-10 parts of cassia seed. The health product is prepared through the following process steps: (a) raw material processing of Dendrobium candidum: wash the fresh product of Dendrobium candidum, cut the stem nodes of Dendrobium candidum into about 6cm, and then coarsely crush them to particles of ≤0.5cm; The raw material of Dendrobium candidum was dried and sterilized at 90° C. for 4 hours; the coarsely crushed dry raw material was put into a supersonic jet mill and pulverized for 10 minutes to obtain superfine powder of Dendrobium candidum with a particle size of 1-75 μm; (b) selected The dry powder of other additives of Dendrobium candidum health products, the dry powder of the additives is put into a supersonic jet mill to pulverize, and the fine powder of the additives with a particle size of less than 2 μm is obtained; (c) the powder obtained in step (b) is added to the step ( a) In the obtained crushed Dendrobium candidum, make it fully mixed, reduce the water content of the crushed Dendrobium candidum to 30%, and obtain the mixed powder; (d) granulate the mixed powder obtained in step (c), first in Perform low-temperature drying treatment at 15-35°C for 4 hours, and then stir the mixed powder after low-temperature treatment at a granulation temperature of 10-130°C within a granulation time of 30-240 minutes to granulate. Obtaining a granulated product with a particle size of less than 300 μm; (e) drying the granulated product obtained in step (d) at a temperature of 40-60° C. until the water content is less than or equal to 8%.

In addition, Chinese patent document CN 102772672B (application number 201210303818.1) discloses a dendrobium candidum ganoderma capsule, which is processed through four steps of dendrobium candidum raw material processing, ultrafine grinding of dendrobium raw material, ultrafine grinding of ganoderma lucidum raw material, mixing and capsule filling be made of. Specifically, the capsule is prepared through the following process steps: (1) raw material processing of Dendrobium candidum: wash the roots and stem nodes of Dendrobium candidum and dry them naturally, and the moisture content of Dendrobium candidum after drying is less than 3% ; (2) Ultra-fine crushing of Dendrobium candidum raw materials: Cut the stem nodes of Dendrobium candidum into 1cm in diameter, and then coarsely crush them to particles with a diameter of ≤0.5cm; Coarsely crushed dry raw materials are put into a supersonic airflow mill for 10 minutes to obtain ultrafine powder of Dendrobium candidum with a particle size of 1-75 μm; (3) Ultrafine grinding of ganoderma raw materials: take the ganoderma lucidum powder and put it into a supersonic airflow mill for pulverization, Obtain Ganoderma lucidum superfine powder with a particle size of less than 2 μm; (4) Mixing: Weigh 5 kg of Ganoderma lucidum superfine powder, first add 10 kg of Dendrobium candidum superfine powder, mix evenly, and then add 10 kg of Dendrobium candidum superfine powder to the mixed powder to continue Mix evenly to obtain the superfine powder raw material; (5) Capsule filling: fill the superfine powder raw material into the capsule shell to obtain Dendrobium officinale Ganoderma lucidum capsules.

Chinese patent document CN 107753754 A (application number 201711109043.3) also discloses a Dendrobium capsule and its preparation process. The Dendrobium capsule includes 3-7 parts by weight of Dendrobium, 13-21 parts of broad-leaved top ten contributions, 10- 20 parts, citron 5-12 parts, catechu 7-25 parts, loquat 28-36 parts.

The dendrobium capsules disclosed above have health care effects such as enhancing immunity and anti-fatigue through the coordinated action of each raw material.

Contents of the invention

The technical problem to be solved by the present invention is to provide a dendrobium capsule with anti-oxidation activity, enhanced immunity, tumor cell inhibitory effect and other health care effects and its preparation method.

The technical solution for realizing the object of the present invention is a dendrobium capsule, and the contents of the capsule are composed of the following components in parts by weight: 40-60 parts of stems of dendrobium, 45-55 parts of Herba Cistanche, 40-55 parts of medlar, 45-55 parts of cooked rehmannia glutinosa 55 parts, Polygala 40-60 parts, Cuscuta 40-55 parts, Dipsacus 40-55 parts, and Tianxiong 1-3 parts.

Preferably, the contents of the capsule are composed of the following components in parts by weight: 45-55 parts of Dendrobium stems, 45-55 parts of Cistanche, 45-55 parts of medlar, 45-55 parts of cooked rehmannia, 45-60 parts of polygala, Cuscuta 45-55 parts, Dipsacus 45-55 parts and Tianxiong 1-2 parts.

Optionally, the contents of the capsule are composed of the following components by weight: 50 parts of Dendrobium stems, 50 parts of Cistanche, 50 parts of Lycium barbarum, 50 parts of cooked rehmannia glutinosa, 50 parts of Polygala, 50 parts of Cuscuta, 50 parts of Dipsacus and male 1.5 parts.

A kind of preparation method of dendrobium capsule as above is characterized in that comprising the following steps:

①Pretreatment of Dendrobium stems: Wash, dry, slice and dry the fresh Dendrobium stems obtained by cutting them for later use.

②Preparation of contents: mix and pulverize the dendrobium stems, cistanche, medlar, cooked and dried rehmannia glutinosa, Polygala, Cuscuta, Dipsacus and Tianxiong weighed according to the prescription, or pulverize and mix separately; sieve and sterilize , get the contents for later use.

③Filling of capsules: filling the contents into the capsule shell to obtain Dendrobium capsules.

Step ② When the content is prepared, the external temperature does not exceed 25°C during the crushing process of raw materials.

The present invention has positive effects: (1) In the dendrobium capsule of the present invention, all the raw materials are crushed and then filled in the capsule shell. During the raw material crushing and capsule filling process, the external temperature does not exceed 25°C, and the cleanliness reaches 300,000-level control District requirements. The temperature of the raw material is controlled during pulverization to keep the biological activity unchanged.

(2) The dendrobium capsule of the present invention has the effects of anti-oxidation, improving immunity and inhibiting tumor through the coordinated action of various raw materials.

Detailed ways

The dendrobium capsule is obtained by filling the content containing the dendrobium into the capsule shell according to the dosage.

(Example 1)

The content of the dendrobium capsule of the present embodiment is composed of the following components by weight: 50 parts of stems of dendrobium, 50 parts of cistanche, 50 parts of medlar, 50 parts of cooked rehmannia glutinosa, 50 parts of polygala, 50 parts of dodder, 50 parts of Dipsacus and Tianxiong 1.5 parts. Each component is crushed and processed into powder. Each component wherein is traditional Chinese medicine.

The preparation method of the dendrobium capsule of the present embodiment comprises the following steps:

① Dendrobium stem pretreatment. Rinse the fresh dendrobium stems obtained by picking and cutting them with clean water. After the water is dried, slice them with a traditional Chinese medicine slicer, and control the thickness of the slices to 0.5-3mm. %),spare.

②Preparation of contents. Mix 50 parts of dendrobium stems, 50 parts of cistanche, 50 parts of medlar, 50 parts of cooked rehmannia glutinosa, 50 parts of polygala, 50 parts of dodder seed, 50 parts of Dipsacus and 1.5 parts of Tianxiong, weighed according to the prescription, and send them into the grinder Grinding in medium, passing through a 100-mesh sieve, taking the powder under the sieve, drying and sterilizing by infrared, and obtaining the content for later use.

When preparing the contents, the raw materials can also be pulverized separately, and then the powdered raw materials can be mixed uniformly to obtain the contents of the capsule.

During the crushing process of raw materials, the external temperature does not exceed 25°C, and the cleanliness meets the requirements of a 300,000-level control area. The temperature of the raw material is controlled during pulverization to keep the biological activity unchanged.

③Filling of capsules (gelatin).

It is filled with a capsule board made of plexiglass. The board is divided into upper and lower layers, and the upper layer has hundreds of holes. First separate the capsule cap and the capsule body, insert the capsule body into the hole of the capsule plate, adjust the distance between the upper and lower layers, and make the capsule mouth level with the plate surface. Spread the content medicine powder prepared in step ② on the surface of the board, and gently vibrate the capsule board to make the medicine powder evenly filled. After filling each capsule, remove excess particles from the surface of the plate, lift the capsule body, close the capsule cap, and take out the dendrobium capsule.

④Quality inspection. Observe whether the appearance of the capsule is smooth and tidy, free from adhesion, deformation and rupture, and free from peculiar smell.

(Example 2)

The content of the dendrobium capsule of the present embodiment is made up of the following components by weight: 50 parts of stems of dendrobium, 45 parts of cistanche, 40 parts of medlar, 50 parts of cooked rehmannia glutinosa, 55 parts of polygala, 45 parts of dodder, 45 parts of Dipsacus and Tianxiong 1 part.

The preparation method is the same as in Example 1, the same below.

(Example 3)

The contents of the dendrobium capsule of the present embodiment are composed of the following components by weight: 50 parts of stems of dendrobium, 55 parts of Cistanche, 55 parts of medlar, 45 parts of cooked rehmannia glutinosa, 55 parts of polygala, 45 parts of dodder, 45 parts of Dipsacus and Tianxiong 2 parts.

(Example 4)

The contents of the dendrobium capsule of the present embodiment are composed of the following components by weight: 55 parts of stems of dendrobium, 50 parts of cistanche, 50 parts of medlar, 45 parts of cooked rehmannia glutinosa, 45 parts of polygala, 45 parts of dodder, 45 parts of Dipsacus and Tianxiong 2 parts.

(Example 5)

The content of the dendrobium capsule of the present embodiment is made up of the following components by weight: 60 parts of stems of dendrobium, 40 parts of cistanche, 50 parts of medlar, 45 parts of cooked rehmannia glutinosa, 50 parts of polygala, 50 parts of dodder, 40 parts of Dipsacus and Tianxiong 3 copies.

(Example 6)

The contents of the dendrobium capsule of the present embodiment are composed of the following components by weight: 40 parts of stems of dendrobium, 55 parts of cistanche, 55 parts of medlar, 55 parts of cooked rehmannia glutinosa, 50 parts of polygala, 50 parts of dodder, 50 parts of Dipsacus and Tianxiong 1.5 parts.

(Test example)

Take the dendrobium capsule of Example 1, pour out the contents, heat extraction according to the mass ratio of 100g contents and 60 degree white wine 1:1, heat extraction twice, extract for the first time for 2 hours, filter on the funnel with skimmed yarn , and the filter residue was leached for the second time for 4 hours, and then filtered again. The two filtrates were combined into an extract, left to stand for 3 days, and then filtered. The filtrate was concentrated and vacuum-dried to obtain the extract.

1. Determination of the ability of the extract to scavenge DPPH free radicals and evaluate its antioxidant activity.

Experimental results: The IC50 value for scavenging DPPH free radicals is 0.086 mg/mL. The experimental results show that the extract of Dendrobium capsules has certain antioxidant activity.

2. Anti-tumor experiments.

The antitumor activity of the extract to human lung cancer cells (A549), human breast cancer cells, and cervical cancer cells was measured by MTT method; the control substance doxorubicin, the detection results are as follows:

IC ₅₀ value of the extract on tumor cell proliferation

The experimental results show that the extract has a certain inhibitory activity on the above three types of cells; among them, the half inhibitory concentration IC50 of cervical cancer Hela and lung adenocarcinoma A549 is less than 100 μg/mL, and the half inhibitory concentration IC50 of breast cancer MCF-7 is greater than 100 μg/mL. mL.

Inspired by the above-mentioned ideal embodiment according to the present invention, through the above-mentioned description content, relevant workers can make various changes and modifications within the scope of not departing from the technical idea of the present invention. The technical scope of the present invention is not limited to the content in the specification, but must be determined according to the scope of the claims.

Claims (5)

1. a dendrobium capsule, is characterized in that the content of capsule is made up of following composition by weight: stem of dendrobium 40～60 parts, Herba Cistanche 45～55 parts, medlar 40～55 parts, cooked rehmannia glutinosa 45～55 parts, Polygala 40-60 parts, Cuscuta 40-55 parts, Dipsacus 40-55 parts, and Tianxiong 1-3 parts. 2. The dendrobium capsule according to claim 1, wherein the content of the capsule is composed of the following components in parts by weight: 45-55 parts of stems of dendrobium, 45-55 parts of Herba Cistanche, 45-55 parts of medlar, cooked and dried rehmannia glutinosa 45-55 parts, Polygala 45-60 parts, Cuscuta 45-55 parts, Dipsacus 45-55 parts and Tianxiong 1-2 parts. 3. the dendrobium capsule according to claim 1, is characterized in that the content of capsule is made up of following composition by weight: 50 parts of stems of dendrobium, 50 parts of Herba Cistanche, 50 parts of medlar, 50 parts of cooked rehmannia glutinosa, 50 parts of polygala , Cuscuta 50 parts, Dipsacus 50 parts and Tianxiong 1.5 parts. 4. a preparation method of dendrobium capsule as claimed in claim 1, is characterized in that comprising the following steps: ① Dendrobium stem pretreatment: the fresh stem of Dendrobium obtained by picking and cutting is cleaned, dried, sliced, and dried for later use; ②Preparation of contents: mix and pulverize the dendrobium stems, cistanche, medlar, cooked and dried rehmannia glutinosa, Polygala, Cuscuta, Dipsacus and Tianxiong weighed according to the prescription, or pulverize and mix separately; sieve and sterilize , get the contents for later use; ③Filling of capsules: filling the contents into the capsule shell to obtain Dendrobium capsules. 5. The preparation method of Dendrobium capsules according to claim 4, characterized in that: step ②, when the content is prepared, the external temperature does not exceed 25°C during the raw material crushing process.