CN108452198A - Cough-relieving apophlegmatic Chinese medicine composition and its preparation method and application - Google Patents

Abstract

The invention provides an antitussive and expectorant traditional Chinese medicine composition and its preparation method and application, and relates to the technical field of traditional Chinese medicine compositions. 5-50 parts of pear juice, 10-25 parts of Luo Han Guo, 10-30 parts of Panda Dahai, 10-33 parts of Chinese wolfberry and 5-26 parts of mulberry. Due to the technical problem of not being able to effectively relieve cough and eliminate phlegm, and having relatively large toxic and side effects, the Chinese medicine composition for relieving cough and eliminating phlegm provided by the present invention can not only be used to relieve phlegm and relieve cough, but also can be used to prevent the occurrence of cough and expectoration. At the same time, the raw materials are all taken from plant Herbal, natural green, nutritious and healthy, will not cause any toxic side effects, and can effectively protect the health of the body.

Description

Chinese medicinal composition for relieving cough and eliminating phlegm, preparation method and application thereof

technical field

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a Chinese medicine composition for relieving cough and eliminating phlegm, a preparation method and application thereof.

Background technique

Cough and phlegm are common symptoms of respiratory diseases. Cough is caused by inflammation of the trachea, bronchial mucosa or pleura, foreign bodies, physical or chemical stimulation. When coughing, the glottis closes first, the respiratory muscles contract, and the intrapulmonary pressure rises. The glottis opens and the air in the lungs is ejected. Coughing up with a collection of fluid is called expectoration. All men, women and children may suffer from this disease throughout the year, and the incidence rate is extremely high. If it is not cured in time, the cough will continue, and the change from acute to chronic often brings greater pain to the patient, such as chest tightness, throat Itching, panting, etc., even if the symptoms are not aggravated, it will affect rest and sleep.

At present, the commonly used drugs for relieving cough and reducing phlegm in Western medicine include ammonium chloride, bisputum, and carboxymethylcysteine, which have a significant effect on suppressing short-term phlegm symptoms, but they cannot effectively relieve cough and eliminate phlegm. And western medicine mostly uses anti-inflammatory and antibiotics to treat, but the side effects are relatively large, especially antibiotics. The abuse of antibiotics will cause serious drug resistance. Some coughs caused by chronic bronchitis should not be treated with antibiotics for a long time .

In view of this, the present invention is proposed.

Contents of the invention

One of the objectives of the present invention is to provide a Chinese medicine composition for relieving cough and eliminating phlegm, so as to improve the technical problem that the existing western medicine can only suppress the symptoms of excessive phlegm in the short term, but cannot effectively relieve cough and eliminate phlegm, and has relatively large toxic and side effects.

The Chinese medicine composition for relieving cough and eliminating phlegm provided by the present invention comprises the following raw materials in parts by mass: 10-60 parts of fresh bamboo leek, 5-50 parts of pear juice, 10-25 parts of Luo Han Guo, 10-30 parts of Panda Dahai, wolfberry 10-33 parts and mulberry 5-26 parts.

Further, the Chinese medicine composition for relieving cough and eliminating phlegm includes the following raw materials in parts by mass: 15-50 parts of fresh bamboo leek, 10-40 parts of pear juice, 8-15 parts of Momordica grosvenori, 10-20 parts of fat sea, wolfberry 10-20 parts and mulberries 5-15 parts.

Further, the Chinese medicine composition for relieving cough and eliminating phlegm includes the following raw materials in parts by mass: 40-50 parts of fresh bamboo leek, 10-20 parts of pear juice, 8-12 parts of Luo Han Guo, 10-15 parts of Panda Dahai, wolfberry 10-15 parts and mulberry 5-10 parts.

Further, the dosage form of the Chinese medicine composition for relieving cough and eliminating phlegm is tablet, powder, pill, capsule, granule and or oral liquid.

Further, the Chinese medicine composition for relieving cough and expectorant also includes auxiliary materials, and the auxiliary materials include at least one of binder, disintegrant, lubricant, essence, sweetener or diluent.

The second object of the present invention is to provide a preparation method of the above-mentioned Chinese medicine composition for relieving cough and expectorant, comprising the following steps:

Extract the Luo Han Guo, Panda Dahai, Lycium barbarum and mulberry to obtain a mixed extract of Luo Han Guo, Panda Dahai, Lycium barbarum and mulberry, mix the mixed extract with fresh bamboo leek and pear juice, concentrate under reduced pressure, and add optional auxiliary materials , that is, a Chinese medicine composition for relieving cough and eliminating phlegm is prepared.

Further, after mixing Luo Han Guo, Panda Dahai, Lycium barbarum and mulberry, the mixed extract of Luo Han Guo, Panda Dahai, Lycium barbarum and mulberry is prepared by extraction.

Further, after mixing Luo Han Guo, Panda Dahai, Lycium barbarum and mulberries, heating and extracting for many times, and then mixing the extracts obtained by multiple times of heating and extracting, a mixed extract of Luo Han Guo, Panda Dahai, Lycium barbarum and mulberries is obtained.

Further, after mixing Luo Han Guo, Panda Dahai, wolfberry and mulberry, add water to soak for 0.5-2 hours, and then heat and extract.

The third object of the present invention is to provide the application of the above-mentioned Chinese medicine composition for relieving cough and eliminating phlegm in food, medicine or health products.

The traditional Chinese medicine composition for relieving cough and phlegm provided by the present invention takes fresh bamboo lek for reducing phlegm and relieving cough as the main drug, and is equipped with pear juice for moistening lung and clearing dryness, Luo Han Guo for moistening lung and relieving cough, promoting body fluid and quenching thirst, Pumice Dahai for clearing lung heat, and supplemented with tonic Lycium barbarum for the lungs and kidneys, mulberry for nourishing the liver, strengthening the spleen and kidneys are used as medicines. Fresh bamboo leek, pear juice, mangosteen, puffy sea, wolfberry and mulberry are used to synergize each other. Cough and sputum occur, and at the same time, the raw materials are all taken from plants and herbs, natural green, nutritious and healthy, will not cause any toxic side effects, and can effectively protect the health of the body.

The preparation method of the Chinese medicine composition for relieving cough and eliminating phlegm provided by the invention has simple process and convenient operation, is applicable to large-scale industrial production, and effectively reduces production cost.

Detailed ways

Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only for illustrating the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all conventional products that could be purchased from the market.

According to one aspect of the present invention, the present invention includes the following raw materials in terms of parts by mass: 10-60 parts of fresh bamboo leek, 5-50 parts of pear juice, 10-25 parts of Luo Han Guo, 10-30 parts of fat sea, 10-33 parts of Chinese wolfberry parts and 5-26 parts of mulberries.

In the present invention, the typical but non-limiting mass parts of fresh bamboo leek are as 10, 12, 15, 18, 20, 22, 25, 28, 30, 32, 35, 38, 40, 42, 45, 48, 50, 52, 55, 58 or 60 servings.

Fresh bamboo leek is sweet and cold in nature and can clear away fire in the heart, lung and stomach, and has the effects of eliminating phlegm, moistening dryness and calming convulsions. Fresh bamboo leek is the juice obtained after processing bamboo. The method of preparation is to take fresh bamboo poles, remove the knots at both ends, split them, roast the middle part with fire, and the juice will flow out from both ends. Collect them to make fresh bamboo leeks.

In the present invention, the typical but non-limiting mass parts of pear juice are as 5, 8, 10, 12, 15, 18, 20, 22, 25, 28, 30, 32, 35, 38, 40, 42 , 45, 48 or 50 servings.

Pear juice tastes sweet and sour, and has the effects of moistening lungs and clearing dryness, relieving cough and reducing phlegm, diuretic, antipyretic, and nourishing blood and strengthening muscles. Therefore, it has good effects on dry throat, itching, pain, hoarseness, and thick phlegm. Pear juice is obtained by squeezing Sydney pears and filtering them.

Typical but non-limiting parts by mass of Luo Han Guo are, for example, 10, 12, 14, 15, 16, 18, 20, 22, 24 or 25 parts.

Luo Han Guo has the effects of moistening the lungs and relieving cough, promoting body fluid and quenching thirst.

Typical but non-limiting parts by mass of Panda Dahai are 10, 12, 14, 15, 16, 18, 20, 22, 24, 25, 26, 28 or 30 parts.

Panda Dahai is sweet in taste and cold in nature, light in quality and dispersing and scattered. It enters the lung meridian to clear and disperse lung qi, and is a good medicine for laryngology;

Typical but non-limiting parts by mass of wolfberry are, for example, 10, 12, 14, 15, 16, 18, 20, 22, 24, 25, 26, 28, 30, 32 or 33 parts.

Lycium barbarum nourishes the liver, nourishes the kidney, and moistens the lungs. It can nourish the lungs and kidneys for patients with cough and phlegm with insufficient lung and kidney qi.

Typical but non-limiting mass parts of mulberries are, for example, 5, 8, 10, 12, 14, 15, 16, 18, 20, 22, 24, 25 or 26 parts.

Mulberry is sweet and cold in nature and taste, has the functions of nourishing the liver, invigorating the spleen and kidney, promoting body fluid and moistening the intestines, and curing liver and kidney yin deficiency, and its taste is sweet and sour.

The traditional Chinese medicine composition for relieving cough and phlegm provided by the present invention takes fresh bamboo leek for reducing phlegm and relieving cough as the main drug, and is combined with pear juice for moistening lungs and clearing dryness, Luo Han Guo for moistening lungs and relieving cough, promoting body fluid and quenching thirst, and Panda Dahai for clearing lung heat, and Lycium barbarum for nourishing the lungs and kidneys, mulberry for nourishing the liver, strengthening the spleen and kidneys are used as medicines, through the synergy of fresh bamboo leek, pear juice, mangosteen, fat sea, wolfberry and mulberries, not only can be used to eliminate phlegm and relieve cough, but also can be used to To prevent cough and sputum, all raw materials are taken from plants and herbs, natural green, nutritious and healthy, without any toxic side effects, and can effectively protect the health of the body.

In a preferred embodiment of the present invention, the Chinese medicine composition for relieving cough and eliminating phlegm is tablet, powder, pill, capsule, granule or oral liquid.

The Chinese medicine composition for relieving cough and eliminating phlegm provided by the present invention can be made into any dosage forms, including but not limited to tablets, powders, pills, capsules, granules or oral liquids.

In a preferred embodiment of the present invention, the Chinese medicine composition for relieving cough and eliminating phlegm further includes auxiliary materials, and the auxiliary materials include at least one of binder, disintegrant, lubricant, essence, sweetener or diluent.

In order to prepare the Chinese medicine composition for relieving cough and eliminating phlegm provided by the present invention into different dosage forms, certain auxiliary materials need to be added during the process, and the auxiliary materials can be selected according to different dosage forms.

According to the second aspect of the present invention, the present invention provides a preparation method of the above-mentioned Chinese medicine composition for relieving cough and expectorant, comprising the following steps:

Extract the Luo Han Guo, Panda Dahai, Lycium barbarum and mulberry to obtain a mixed extract of Luo Han Guo, Panda Dahai, Lycium barbarum and mulberry, mix the mixed extract with fresh bamboo leek and pear juice, concentrate under reduced pressure, and add optional auxiliary materials , that is, a Chinese medicine composition for relieving cough and eliminating phlegm is prepared.

In the present invention, the active ingredients in Luo Han Guo, Panda Hai, Lycium barbarum and mulberry are extracted by extracting Luo Han Guo, Panda Dahai, Lycium barbarum and mulberry, which is more conducive to the body's absorption and better therapeutic effect.

The preparation method of the Chinese medicine composition for relieving cough and eliminating phlegm provided by the invention has simple process and convenient operation, is applicable to large-scale industrial production, and effectively reduces production cost.

In a preferred embodiment of the present invention, after mixing Luo Han Guo, Panda Dahai, Lycium barbarum and mulberry, the mixed extract of Luo Han Guo, Panda Dahai, Lycium barbarum and mulberry is prepared by extraction.

By first mixing the Luo Han Guo, Panda Dahai, wolfberry and mulberry, and then extracting the active ingredients of the above raw materials, it is beneficial to simplify the process, improve the preparation efficiency and reduce the production cost.

In a further preferred embodiment of the present invention, after mixing Luo Han Guo, Panda Dahai, Lycium barbarum and mulberry, heat and extract for many times, and then mix the extracts obtained by multiple times of heating and extracting to obtain Luo Han Guo, Panda Dahai, Lycium barbarum and the mixed extract of mulberry.

The active ingredients of the above-mentioned raw materials are fully extracted by heating and extracting the mixture of Luo Han Guo, Panda Dahai, wolfberry and mulberry several times to further improve the efficacy and therapeutic effect.

In a further preferred embodiment of the present invention, after mixing Luo Han Guo, Panda Dahai, Lycium barbarum and mulberries, add water to soak for 0.5-2 hours, and then heat and extract.

After mixing Luo Han Guo, Panda Dahai, wolfberry and mulberry, add water and soak for 0.5-2 hours, so as to facilitate the subsequent extraction process and improve extraction efficiency.

In a typical but non-limiting embodiment of the present invention, the time of soaking in water is 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9 or 2h.

According to the third aspect of the present invention, the present invention provides the application of the above-mentioned antitussive and expectorant traditional Chinese medicine composition in food, medicine or health products.

In the present invention, food includes but not limited to liquid beverage, solid beverage, candy or pastry, etc.

Medicines include but are not limited to buccal tablets, effervescent tablets, oral liquids or granules, etc.

The technical solutions provided by the present invention will be further described below in conjunction with examples and comparative examples.

Example 1

This embodiment provides a Chinese medicine composition for relieving cough and eliminating phlegm, including the following raw materials in parts by mass: 10 parts of fresh bamboo leek, 50 parts of pear juice, 10 parts of Luo Han Guo, 30 parts of Panda Dahai, 33 parts of wolfberry and 5 parts of mulberry share.

Example 2

This example provides a Chinese medicine composition for relieving cough and eliminating phlegm, including the following raw materials in parts by mass: 60 parts of fresh bamboo leek, 5 parts of pear juice, 25 parts of Luo Han Guo, 10 parts of Panda Dahai, 10 parts of wolfberry and 26 parts of mulberry share.

Example 3

This embodiment provides a Chinese medicine composition for relieving cough and expectorant, including the following raw materials in parts by mass: 50 parts of fresh bamboo leek, 10 parts of pear juice, 15 parts of Luo Han Guo, 10 parts of Panda Dahai, 20 parts of wolfberry and 5 parts of mulberry share.

Example 4

This embodiment provides a Chinese medicine composition for relieving cough and eliminating phlegm, including the following raw materials in parts by mass: 15 parts of fresh bamboo leek, 40 parts of pear juice, 8 parts of Luo Han Guo, 20 parts of Panda Dahai, 10 parts of wolfberry and 15 parts of mulberry share.

Example 5

This example provides a Chinese medicine composition for relieving cough and expectorant, including the following raw materials in parts by mass: 40 parts of fresh bamboo leek, 20 parts of pear juice, 8 parts of Luo Han Guo, 15 parts of Panda Dahai, 10 parts of wolfberry and 10 parts of mulberry share.

Example 6

This embodiment provides a Chinese medicine composition for relieving cough and expectorant, including the following raw materials in parts by mass: 50 parts of fresh bamboo leek, 10 parts of pear juice, 12 parts of Luo Han Guo, 10 parts of Panda Dahai, 15 parts of wolfberry and 5 parts of mulberry share.

Example 7

This embodiment provides a Chinese medicine composition for relieving cough and eliminating phlegm, including the following raw materials in parts by mass: 45 parts of fresh bamboo leek, 15 parts of pear juice, 12 parts of wolfberry, 8 parts of mulberry, 10 parts of Luo Han Guo, and 12 parts of fat sea share.

Example 8

This example provides a method for preparing a cough-relieving and expectorant traditional Chinese medicine composition. The cough-relieving and expectorant traditional Chinese medicine compositions provided in Examples 1-7 are all prepared according to this method, specifically including the following steps:

(a) firstly crush Luo Han Guo, Panda Dahai, wolfberry and mulberry respectively, mix them, add water and soak for 1 hour;

(b) decocting the soaked Luo Han Guo, Panda Dahai, Chinese wolfberry, and mulberry several times, and combining the multiple decoctions and soaking liquids to obtain a mixed extract of Luo Han Guo, Panda Dahai, Chinese wolfberry, and mulberry, filtering, and merging filtrate;

(c) After the filtrate is allowed to cool, it is evenly mixed with fresh bamboo lees and pear juice, and then the traditional Chinese medicine composition for relieving cough and eliminating phlegm is obtained.

Comparative example 1

This comparative example provides a Chinese medicine composition for relieving cough and eliminating phlegm. This comparative example includes the following raw materials in parts by mass: 80 parts of fresh bamboo leek, 2 parts of pear juice, 45 parts of wolfberry, 2 parts of mulberry, 40 parts of Luo Han Guo, 5 servings of fat sea.

Comparative example 2

This comparative example provides a Chinese medicine composition for relieving cough and eliminating phlegm. This comparative example includes the following raw materials in parts by mass: 5 parts of fresh bamboo leek, 80 parts of pear juice, 5 parts of wolfberry, 40 parts of mulberry, 5 parts of Luo Han Guo, 40 servings of fat sea.

Comparative example 3

Comparative Example 3 provides a traditional Chinese medicine composition for relieving cough and eliminating phlegm. The difference between this Comparative Example and Example 7 is that Panda Dahai is not added.

Comparative example 4

Comparative Example 4 provides a Chinese medicine composition for relieving cough and eliminating phlegm. The difference between this Comparative Example and Example 7 is that Panda Dahai and Luo Han Guo are not added.

Comparative example 5

Comparative Example 5 provides a Chinese medicine composition for relieving cough and eliminating phlegm. The difference between this Comparative Example and Example 7 is that Luo Han Guo is not added.

Comparative example 6

Comparative Example 6 provides a Chinese medicine composition for relieving cough and eliminating phlegm. The difference between this Comparative Example and Example 7 is that fresh bamboo leek is not added.

Comparative example 7

Comparative Example 7 provides a Chinese medicine composition for relieving cough and eliminating phlegm. The difference between this Comparative Example and Example 7 is that fresh bamboo leek and pear juice are not added.

Comparative example 8

Comparative Example 8 provides a Chinese medicine composition for relieving cough and eliminating phlegm. The difference between this Comparative Example and Example 7 is that no pear juice is added.

The preparation method of the antitussive and expectorant traditional Chinese medicine composition provided in Comparative Examples 1-8 is the same as in Example 7, and will not be repeated here.

Test Example 1 Mouse Ammonia Induced Cough Test

Get Kunming kind 20g ± 2g mice 170 (half and half male and female), after 3 days of adaptive feeding, divide mice into 17 groups at random according to body weight: control group, positive group, embodiment group 1-7, comparative example Groups 1-8, 10 rats in each group, fasted for 12 hours before the experiment. The doses in Table 1 were given by intragastric administration, the blank group was given 0.9% normal saline, and the positive group was given codeine for 3 consecutive days, and the experiment started 1 hour after the last administration. Put the mouse in a 500ml glass bell jar, spray it with 25%-28% concentrated ammonia water quantitatively, take it out after being stimulated in the ammonia environment for 20s, observe and record the cough latency of the mouse and the number of coughs within 5min, As shown in table 2.

Table 1 The way of administration dosage days of ammonia water induced cough test in mice

Table 2 The cough latency of the mice and the number of times of coughing within 5min

Note: Compared with the control group, **P<0.01, *P<0.05.

From the comparison between Examples 1-7 and the control group in Table 2, it can be seen that the Chinese medicine composition for relieving cough and expectorant provided by Examples 1-7, through the mutual synergy of fresh bamboo leek, pear juice, Momordica grosvenori, fat sea, wolfberry and mulberry , has a significant antitussive effect, can significantly prolong the incubation period of cough, and reduce the number of coughs within 3 minutes.

Through the comparison of Examples 1-7 and Comparative Examples 1-8, it can be seen that the Chinese medicine for relieving cough and expectorant is made by synergizing with fresh bamboo leek, pear juice, monk fruit, fat sea, wolfberry and mulberry in specific mass fractions The antitussive effect of the composition is more significant, the incubation period of the cough is longer, and the number of coughs within 3 minutes is less.

Through the comparison of Example 7 and Comparative Examples 3-5, it can be seen that the cough-relieving and expectorant traditional Chinese medicine composition is made by adding Panda Dahai and Luo Han Guo to the raw materials, and then synergizing with fresh bamboo juice, pear juice, wolfberry and mulberry The antitussive effect is significantly higher than that of adding a single Panda Dahai or Luo Han Guo, which shows that Luo Han Guo and Panda Dahai can have a synergistic effect with other raw materials, so that the antitussive effect of the Chinese medicine composition for relieving cough and eliminating phlegm is greatly improved.

Through the comparison of Example 7 and Comparative Examples 6-8, it can be seen that the Chinese medicine composition for relieving cough and eliminating phlegm is made by adding fresh bamboo leek and pear juice to the raw materials, and then synergizing with Luo Han Guo, Panda Dahai, Lycium barbarum and mulberry The antitussive effect of this product is significantly higher than that of adding a single fresh bamboo leek or pear juice, which shows that the fresh bamboo leek and pear juice can have a synergistic effect with other raw materials, so that the antitussive effect of the Chinese medicine composition for relieving cough and expectorant is greatly improved.

As can be seen from the comparison between Example 7 and the positive group, the antitussive effect of the Chinese medicine composition for antitussive and expectorant provided by Example 7 is equivalent to that of codeine in the same dose, but the Chinese medicine composition for antitussive and expectorant provided by this example uses The raw materials are all taken from medicinal and edible plants, without any toxic and side effects, allowing people to achieve the effect of conditioning the body and preventing cough while diet therapy.

In addition, this test took Example 7 and Comparative Example 3 and Comparative Example 4 as an example to measure the impact of different dosages on the mice cough effect. The mice used in this test are the same as the above-mentioned test, and the number of each group is also 10 animals, the test method is also the same, the dosage and mode of administration are shown in Table 3, and the results are shown in Table 4.

Table 3 Ammonia induced cough test in mice Administration dose days table

Table 4 The cough latency of the mice and the number of times of coughing within 5min

Note: Compared with the control group, **P<0.01, *P<0.05.

It can be seen from Table 3 and Table 4 that the antitussive effect of the antitussive and expectorant traditional Chinese medicine composition provided by Example 7 is still significantly higher than that of Comparative Examples 3-4 at different dosages.

Test Example 2 Mouse Tracheal Phenol Red Excretion (Expecting Phlegm) Experiment

Get 170 Kunming 20g ± 2g mice (half male and half male), and after adaptive feeding for 3 days, they were randomly divided into 17 groups according to body weight: control group, positive group, experimental group 1-7 groups, each group 10 rats were marked and fasted without water for 12 hours before the experiment. The doses in Table 5 were given by intragastric administration, and the blank group was given 0.9% normal saline for 7 consecutive days. 30 minutes after the last administration, each mouse was intraperitoneally injected with 0.5% phenol red solution 0.25ml/10g, and then removed after another 30 minutes. The cervical spine was sacrificed. Cut from the neck, separate the trachea, cut off a section of the trachea from the lower edge of the thyroid cartilage to the bifurcation of the trachea, peel off the tissue around the trachea with tweezers, and immediately put it into a test tube containing 1.5 mL of 5% sodium bicarbonate solution. Soak for 5 hours and centrifuge at 5000r/min for 10min. Take the supernatant, use 5% sodium bicarbonate solution as a blank control, and measure the absorbance (A) at a wavelength of 546 nm with an ultraviolet spectrophotometer. The expectorant effect was judged by recording the excretion of phenol red in the trachea (the more the excretion of phenol red in the trachea, the better the expectorant effect), as shown in Table 6.

Table 5 mice tracheal phenol red secretion (expectation of the phlegm) test administration dosage days table

The phenol red absorption value of table 6 mouse trachea phenol red excretion (expect expectorant) test

Note: Compared with the control group, **P<0.01, *P<0.05; because the comparative examples 6-7 did not contain fresh bamboo leek, the absorption value of phenol red could not be determined.

From the comparison of Examples 1-7 and the control group in Table 6, it can be seen that the Chinese medicine composition for relieving cough and expectorant provided by Examples 1-7, through the mutual synergy of fresh bamboo leek, pear juice, Luo Han Guo, fat sea, wolfberry and mulberry , has a significant expectorant effect and can increase the amount of expectorant.

Through the comparison of Examples 1-7 and Comparative Examples 1-8, it can be seen that the Chinese medicine for relieving cough and expectorant is made by synergizing with fresh bamboo leek, pear juice, monk fruit, fat sea, wolfberry and mulberry in specific mass fractions The composition has more significant effect of removing phlegm, and the amount of removing phlegm is larger.

Through the comparison of Example 7 and Comparative Examples 3-5, it can be seen that the cough-relieving and expectorant traditional Chinese medicine composition is made by adding Panda Dahai and Luo Han Guo to the raw materials, and then synergizing with fresh bamboo juice, pear juice, wolfberry and mulberry The cough-relieving effect is significantly higher than adding a single Panda Dahai or Luo Han Guo, which shows that Luo Han Guo and Panda Dahai can have a synergistic effect with other raw materials, so that the expectorant effect of the cough-relieving and expectorant traditional Chinese medicine composition is greatly improved.

Through the comparison of Example 7 and Comparative Example 8, it can be seen that the antitussive and expectorant Chinese medicine composition made by adding pear juice to the raw materials, and then synergizing with fresh bamboo grosvenor fruit, fat sea, wolfberry and mulberry has antitussive effect Significantly higher than adding a single fresh bamboo leek, which shows that the pear juice can have a synergistic effect with other components, so that the expectorant effect of the Chinese medicine composition for relieving cough and expectorant is greatly improved.

Through the comparison of Example 7 and the positive group, it can be seen that the expectorant effect of the Chinese medicine composition for relieving cough and expectorant provided by Example 7 is equivalent to that of ammonium chloride of the same dose, but the Chinese medicine composition for stopping cough and expectorant provided by the present embodiment has the same effect. The raw materials used are all taken from the same medicine and food plants, without any toxic and side effects, which can allow people to achieve the effect of conditioning the body and preventing cough while diet therapy.

In addition, this test took Example 7 and Comparative Example 3 and Comparative Example 4 as an example to measure the impact on the expectorant effect on mice when different dosages were administered. Also 10, the test method is also the same, the dosage and mode of administration are shown in Table 7, and the results are shown in Table 8.

Table 7 Mice Tracheal Phenol Red Excretion (Expectant Phlegm) Test Administration Dosage Days Table

The phenol red absorption value of table 8 mouse trachea phenol red excretion (expect expectorant) test

Note: Compared with the control group, **P<0.01, *P<0.05

It can be seen from Table 3 and Table 4 that the expectorant effect of the antitussive and expectorant traditional Chinese medicine composition provided by Example 7 is still significantly higher than that of Comparative Examples 3-4 at different dosages.

Test example 3 mouse toxicity test

Adopt the maximum dosage test method, get Kunming kind 20g ± 2g mouse 40 (male and female half and half), be divided into 2 groups at random, be respectively control group and embodiment 7 groups, every group of 20, with 40g/kg body weight The amount of administration was administered twice in 24 hours, with an interval of 6 hours between the two times, and the animal's behavior, mental state, skin color, stool and body weight were observed for 14 consecutive days.

The results showed that there were no abnormal changes in the behavioral activities, mental state, skin color, stool and secretions of the mice in the two groups after administration, and the body weight changes were within the normal range (P<0.05); the mice were dissected after the observation. No abnormal pathological changes were found in the major organs. This shows that the cough-relieving and expectorant traditional Chinese medicine composition provided by the present invention has no obvious acute toxic reaction.

It can be seen from the comprehensive test examples 1-3 that the traditional Chinese medicine composition for relieving cough and expectorant provided by the present invention can not only quickly eliminate phlegm and relieve cough, but also prevent In case of cough and phlegm, at the same time, all raw materials are selected from plants and herbs, which are natural green, nutritious and healthy, and have no toxic and side effects, which can effectively ensure the health of the body.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present invention, rather than limiting them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: It is still possible to modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the technical solutions of the various embodiments of the present invention. scope.

Claims (10)

1. A Chinese medicinal composition for relieving cough and eliminating phlegm, characterized in that it comprises the following raw materials in parts by mass: 10-60 parts of fresh bamboo leek, 5-50 parts of pear juice, 10-25 parts of Momordica grosvenori, 10-60 parts of Panda Dahai 30 parts, 10-33 parts of wolfberry and 5-26 parts of mulberry. 2. The Chinese medicine composition for relieving cough and eliminating phlegm according to claim 1, characterized in that it comprises the following raw materials in parts by mass: 15-50 parts of fresh bamboo leek, 10-40 parts of pear juice, 8-15 parts of Luo Han Guo , 10-20 parts of fat sea, 10-20 parts of wolfberry and 5-15 parts of mulberry. 3. The Chinese medicine composition for relieving cough and expectorant according to claim 1, characterized in that it comprises the following raw materials in parts by mass: 40-50 parts of fresh bamboo leek, 10-20 parts of pear juice, 8-12 parts of Luo Han Guo , 10-15 parts of fat sea, 10-15 parts of wolfberry and 5-10 parts of mulberry. 4. The Chinese medicine composition for relieving cough and expectorant according to any one of claims 1-3, wherein the dosage form of the Chinese medicine composition for relieving cough and expectorant is tablet, powder, pill, capsule, granule or oral liquid. 5. The Chinese medicine composition for relieving cough and expectorant according to any one of claims 1-3, characterized in that, it also includes adjuvants selected from binders, disintegrants, lubricants, essences, sweeteners or at least one of diluents. 6. The preparation method of the Chinese medicine composition for relieving cough and eliminating phlegm according to any one of claims 1-5, characterized in that, comprising the steps of: Extract the Luo Han Guo, Panda Dahai, Lycium barbarum and mulberry to obtain a mixed extract of Luo Han Guo, Panda Dahai, Lycium barbarum and mulberry, mix the mixed extract with fresh bamboo juice and pear juice, concentrate under reduced pressure, and add optional auxiliary materials , that is, a Chinese medicine composition for relieving cough and eliminating phlegm is prepared. 7. The preparation method of the Chinese medicine composition for relieving cough and eliminating phlegm according to claim 6, characterized in that, after mixing Luo Han Guo, Panda Dahai, Lycium barbarum and mulberry, and then preparing Luo Han Guo, Panda Dahai, Lycium barbarum and A mixed extract of mulberries. 8. The preparation method of the Chinese medicine composition for relieving cough and eliminating phlegm according to claim 6, characterized in that, after mixing Luo Han Guo, Panda Dahai, Lycium barbarum and mulberry, carry out multiple heating extractions, and then multiple heating extractions to obtain The extracts are mixed to obtain the mixed extracts of Luo Han Guo, Panda Dahai, wolfberry and mulberry. 9. The preparation method of the Chinese medicine composition for relieving cough and eliminating phlegm according to claim 8, characterized in that, after mixing Luo Han Guo, Panda Dahai, Lycium barbarum and mulberry, add water to soak for 0.5-2h, and then heat and extract. 10. The application of the Chinese medicine composition for relieving cough and eliminating phlegm according to any one of claims 1-5 in food, medicine or health products.