CN108432743B - Portable organ donation donor mechanical perfusion system - Google Patents
Portable organ donation donor mechanical perfusion system Download PDFInfo
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- CN108432743B CN108432743B CN201810623202.XA CN201810623202A CN108432743B CN 108432743 B CN108432743 B CN 108432743B CN 201810623202 A CN201810623202 A CN 201810623202A CN 108432743 B CN108432743 B CN 108432743B
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- 210000000056 organ Anatomy 0.000 title claims abstract description 60
- 230000010412 perfusion Effects 0.000 title claims abstract description 40
- 239000008280 blood Substances 0.000 claims abstract description 65
- 210000004369 blood Anatomy 0.000 claims abstract description 65
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 42
- 230000017531 blood circulation Effects 0.000 claims abstract description 15
- 238000006213 oxygenation reaction Methods 0.000 claims abstract description 14
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 23
- 229910052760 oxygen Inorganic materials 0.000 claims description 23
- 239000001301 oxygen Substances 0.000 claims description 23
- 230000004872 arterial blood pressure Effects 0.000 claims description 12
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 4
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 3
- 239000001569 carbon dioxide Substances 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 239000004065 semiconductor Substances 0.000 claims description 3
- 208000007536 Thrombosis Diseases 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 210000000702 aorta abdominal Anatomy 0.000 abstract description 6
- 230000003187 abdominal effect Effects 0.000 abstract description 5
- 230000002631 hypothermal effect Effects 0.000 abstract description 4
- 238000002350 laparotomy Methods 0.000 abstract description 4
- 239000007788 liquid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 description 7
- 238000002054 transplantation Methods 0.000 description 5
- 238000002618 extracorporeal membrane oxygenation Methods 0.000 description 4
- 208000007204 Brain death Diseases 0.000 description 2
- 238000005429 filling process Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 208000037906 ischaemic injury Diseases 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 239000000162 organ preservation solution Substances 0.000 description 2
- 238000005057 refrigeration Methods 0.000 description 2
- 206010049993 Cardiac death Diseases 0.000 description 1
- 206010011906 Death Diseases 0.000 description 1
- 208000010496 Heart Arrest Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008081 blood perfusion Effects 0.000 description 1
- 210000002434 celiac artery Anatomy 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 210000003240 portal vein Anatomy 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
- A01N1/142—Apparatus
- A01N1/143—Apparatus for organ perfusion
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Abstract
本发明公开了一种便携式器官捐献供体机械灌注系统，包括血液循环氧合闭合装置以及与血液循环氧合闭合装置电性连接的控制装置，该血液循环氧合闭合装置包括氧合器、离心泵、血液置换器、动脉插管和静脉插管，其中血液置换器内设置有可上下移动的活塞，活塞的上部为用于储存供体血液第一储存端，活塞的下部为用于储存灌注液的第二储存端，血液输入端和离心泵的输出端通过第一三通阀连通第一储存端，血液输入端和离心泵输出端通过第二三通阀连通第二储存端，从而使得不需要再开腹后对腹主动脉再插管就可以完成低温灌注。而且，由于动脉插管的头端设置有球囊，当仅对腹部器官进行灌注时，只需要对球囊进行充气或注水即可，较为方便。
The invention discloses a portable mechanical perfusion system for organ donation, which includes a blood circulation oxygenation closure device and a control device electrically connected with the blood circulation oxygenation closure device, the blood circulation oxygenation closure device includes an oxygenator, a centrifuge Pump, blood displacer, arterial cannula and venous cannula, wherein the blood displacer is equipped with a piston that can move up and down, the upper part of the piston is used to store the first storage end of the donor blood, and the lower part of the piston is used to store the perfusion The second storage end of the liquid, the blood input end and the output end of the centrifugal pump are connected to the first storage end through the first three-way valve, and the blood input end and the output end of the centrifugal pump are connected to the second storage end through the second three-way valve, so that Hypothermic perfusion can be accomplished without recannulation of the abdominal aorta after laparotomy. Moreover, since the head end of the arterial cannula is provided with a balloon, when only the abdominal organs are perfused, only the balloon needs to be inflated or filled with water, which is more convenient.
Description
技术领域technical field
本发明涉及医疗器械技术领域，具体涉及一种便携式器官捐献供体机械灌注系统。The invention relates to the technical field of medical devices, in particular to a portable mechanical perfusion system for organ donation.
背景技术Background technique
器官移植是终末期器官疾病患者唯一治疗方案，但是供体器官的匮乏严重制约了器官移植治疗，随着国家推进并进一步深化器官移植领域改革，公民逝世器官捐献已成为我国供体器官来源的主要途径。Organ transplantation is the only treatment option for patients with end-stage organ diseases, but the shortage of donor organs seriously restricts organ transplantation treatment. As the country promotes and further deepens the reform in the field of organ transplantation, organ donation from deceased citizens has become the main source of donor organs in my country way.
我国公民逝世器官捐献可分为三类，即脑死亡(DBD)、心死亡(DCD)和脑心双死亡(DBCD)器官捐献，其中DCD和DBCD供体器官获取前都不可避免地要经历低血压、休克、心脏停跳等造成的热缺血损伤，从而对器官质量产生严重影响，并最终危及移植受者安全。临床上为了减轻或避免器官移植过程中的热缺血损伤，目前采用的方法是：利用体外膜肺氧合(ECMO)设备对供体器官进行常温灌注，在器官获取时停止ECMO灌注，然后开腹手术对腹主动脉、门静脉插管并灌注低温器官保存液，低温灌注过程获取器官。Organ donations from deceased citizens in our country can be divided into three categories, namely, brain death (DBD), cardiac death (DCD) and brain-death double death (DBCD) organ donations, among which DCD and DBCD donors will inevitably experience hypotension before obtaining organs , shock, cardiac arrest, etc. caused by warm ischemic injury, which has a serious impact on organ quality, and ultimately endanger the safety of transplant recipients. Clinically, in order to reduce or avoid warm ischemic injury in the process of organ transplantation, the current method is: use extracorporeal membrane oxygenation (ECMO) equipment to perfuse the donor organ at room temperature, stop ECMO perfusion when the organ is harvested, and then start In the abdominal operation, the abdominal aorta and portal vein were intubated and perfused with low-temperature organ preservation solution, and the organs were harvested during the low-temperature perfusion process.
ECMO支持下供体器官获取存在以下缺点：(1)灌注血液分布全身，无法做到灌注仅仅针对腹部器官；(2)不能在灌注过程适时将常温血液转换成低温器官保存液；(3)灌注过程不能根据需要迅速降低捐献器官的温度；(4)ECMO设备复杂，体积较大，携带不方便。Donor organ harvesting under the support of ECMO has the following disadvantages: (1) the perfusion blood is distributed throughout the body, and the perfusion cannot only target the abdominal organs; (2) the normothermic blood cannot be converted into a low-temperature organ preservation solution in a timely manner during the perfusion process; (3) perfusion The process cannot quickly lower the temperature of the donated organ as needed; (4) ECMO equipment is complex, bulky, and inconvenient to carry.
发明内容Contents of the invention
本发明所要解决的技术问题是提供一种便携式器官捐献供体机械灌注系统，其不仅可以对器官捐献供体进行常温血液循环支持，而且可以根据需要适时仅对捐献器官进行常温血液灌注或低温器官保存液灌注，尤其是不需开腹手术即可低温灌注捐献器官并迅速降低捐献器官温度。The technical problem to be solved by the present invention is to provide a portable mechanical perfusion system for organ donation, which can not only provide normal temperature blood circulation support for organ donation donors, but also perform normal temperature blood perfusion or low temperature organ transplantation on donated organs as needed. Preservative fluid perfusion, especially the hypothermic perfusion of donated organs without laparotomy and the rapid reduction of the temperature of donated organs.
为解决上述问题，本发明采用的技术方案如下：In order to solve the above problems, the technical scheme adopted in the present invention is as follows:
便携式器官捐献供体机械灌注系统，包括血液循环氧合闭合装置以及与血液循环氧合闭合装置电性连接的控制装置。所述血液循环氧合闭合装置包括氧合器、离心泵、血液置换器、动脉插管和静脉插管，其中：A portable mechanical perfusion system for organ donation, including a blood circulation oxygenation closure device and a control device electrically connected to the blood circulation oxygenation closure device. The blood circulation oxygenation closure device includes an oxygenator, a centrifugal pump, a blood replacer, an arterial cannula and a venous cannula, wherein:
所述氧合器设置有用于连接氧气源的第一输入端、用于排出二氧化碳的第一输出端、用于连接所述离心泵的输出端的血液输入端以及用于连接所述动脉插管的血液输出端；The oxygenator is provided with a first input port for connecting to an oxygen source, a first output port for discharging carbon dioxide, a blood input port for connecting to the output port of the centrifugal pump, and a port for connecting to the arterial cannula. blood outlet;
所述离心泵的输入端与所述静脉插管相连通；The input end of the centrifugal pump communicates with the venous cannula;
所述血液置换器内设置有可上下移动的活塞，所述活塞的上部为用于储存供体血液第一储存端，所述活塞的下部为用于储存灌注液的第二储存端，所述血液输入端和所述离心泵输出端通过第一三通阀连通所述第一储存端，所述血液输入端和所述离心泵输出端通过第二三通阀连通所述第二储存端。The blood displacer is provided with a piston that can move up and down. The upper part of the piston is a first storage end for storing donor blood, and the lower part of the piston is a second storage end for storing perfusate. The blood input end and the centrifugal pump output end communicate with the first storage end through a first three-way valve, and the blood input end and the centrifugal pump output end communicate with the second storage end through a second three-way valve.
进一步地，所述动脉插管的头端设置有球囊。Further, the head end of the arterial cannula is provided with a balloon.
进一步地，所述控制装置内可拆卸连接有带有制冷件的变温水箱，所述氧合器上还设置有用于连接所述变温水箱出水端的第二输入端、以及用于连接所述变温水箱进水端的第二输出端。Further, a temperature-variable water tank with a refrigeration element is detachably connected to the control device, and the oxygenator is also provided with a second input end for connecting the water outlet end of the temperature-variable water tank, and a second input end for connecting the water outlet of the variable temperature water tank. The second output end of the water inlet end of the variable temperature water tank.
更进一步地，所述制冷件由半导体材料制成。Furthermore, the cooling element is made of semiconductor material.
优选地，还包括动脉压力传感器和静脉压力传感器，并且所述动脉压力传感器的一端电性连接所述控制装置，所述动脉压力传感器的另一端通过第三三通阀连接在所述血液输出端与所述动脉插管之间的管路上；所述静脉压力传感器的一端电性连接所述控制装置，所述静脉压力传感器的另一端通过第四三通阀连接在所述离心泵的输入端与所述静脉插管之间的管路上。Preferably, an arterial pressure sensor and a venous pressure sensor are also included, and one end of the arterial pressure sensor is electrically connected to the control device, and the other end of the arterial pressure sensor is connected to the blood output end through a third three-way valve On the pipeline between the arterial cannula; one end of the venous pressure sensor is electrically connected to the control device, and the other end of the venous pressure sensor is connected to the input end of the centrifugal pump through a fourth three-way valve On the pipeline between the venous cannula.
优选地，还包括血氧饱和度传感器，所述血氧饱和度传感器的一端电性连接所述控制装置，所述血氧度传感器的另一端通过第五三通阀连接在所述离心泵的输入端与所述静脉插管之间的管路上。Preferably, a blood oxygen saturation sensor is also included, one end of the blood oxygen saturation sensor is electrically connected to the control device, and the other end of the blood oxygen sensor is connected to the centrifugal pump through a fifth three-way valve. On the pipeline between the input end and the venous cannula.
优选地，还包括流量传感器，所述流量传感器的一端电性连接所述控制装置，所述流量传感器的另一端连接在所述离心泵的输出端与所述血液输入端之间的管路上。Preferably, a flow sensor is further included, one end of the flow sensor is electrically connected to the control device, and the other end of the flow sensor is connected to the pipeline between the output end of the centrifugal pump and the blood input end.
优选地，还包括温度传感器，所述温度传感器的一端电性连接所述控制装置，所述温度传感器的另一端连接在所述第一输入端与所述变温水箱出水端的管路上。Preferably, a temperature sensor is also included, one end of the temperature sensor is electrically connected to the control device, and the other end of the temperature sensor is connected to the pipeline between the first input end and the water outlet end of the variable temperature water tank.
优选地，所述血液输入端与所述第一三通阀之间的管路上设置有血栓过滤装置。Preferably, a thrombus filtering device is provided on the pipeline between the blood input end and the first three-way valve.
相比现有技术，本发明具有以下有益效果：Compared with the prior art, the present invention has the following beneficial effects:
(1)由于所述血液输入端和所述离心泵输出端通过第一三通阀连通所述第一储存端，所述血液输入端和所述离心泵输出端通过第二三通阀连通所述第二储存端，当需要进行低温灌注时，首先将所述第一三通阀与所述血液输入端之间的管路关闭，然后所述离心泵开始工作，器官内的血液将会被引出到所述第一储存端中并推动所述活塞向下移动，此时所述第二储存端中的灌注液将会进入所述氧合器中与氧气进行结合，同时所述控制装置控制所述变温水箱的制冷件开始工作，使得从所述变温水箱中流入到氧合器中与结合氧气的灌注液进行热交换的水的温度为4℃，最后结合氧气的低温灌注液将会依次流经所述血液输出端、所述动脉插管后进入人体，因此，所述便携式器官捐献供体机械灌注系统将不需要在开腹后对腹主动脉进行再插管就可以完成低温灌注。(1) Since the blood input end and the centrifugal pump output end are connected to the first storage end through the first three-way valve, the blood input end and the centrifugal pump output end are connected to the storage end through the second three-way valve. For the second storage end, when low temperature perfusion is required, the pipeline between the first three-way valve and the blood input end is first closed, and then the centrifugal pump starts to work, and the blood in the organ will be drawn into the first storage end and push the piston to move downward, at this time, the perfusate in the second storage end will enter the oxygenator to combine with oxygen, and the control device controls The refrigeration unit of the variable temperature water tank starts to work, so that the temperature of the water flowing from the variable temperature water tank into the oxygenator for heat exchange with the oxygen-combined perfusate is 4°C, and finally the low-temperature perfusate combined with oxygen will will sequentially flow through the blood output port, the arterial cannula and then enter the human body. Therefore, the portable organ donation donor mechanical perfusion system will not need to re-cannulate the abdominal aorta after laparotomy to complete hypothermic perfusion.
(2)由于所述动脉插管的头部设置有球囊，当仅对腹部器官及以下器官进行灌注时，只需要将所述动脉插管的头端放置到腹腔动脉干以上，然后对所述球囊充气或注水就可以阻断腹腔动脉干以上的腹部主动脉，较为方便。(2) Since the head of the arterial cannula is provided with a balloon, when only the abdominal organs and the following organs are perfused, only the head of the arterial cannula needs to be placed above the celiac trunk, and then all The abdominal aorta above the celiac trunk can be blocked by balloon inflation or water injection, which is relatively convenient.
(3)由于所述变温水箱内设置有制冷件，因而在灌注的过程中，通过所述控制装置控制所述制冷件进行工作，就可以使得从所述变温水箱中流出并流入所述氧合器中与存储液进行热交换的水的水温迅速降低到4℃，进而使得供体器官可以迅速降温至4℃。(3) Since the variable temperature water tank is provided with a refrigerating element, during the filling process, the control device controls the refrigerating element to work, so that it can flow out of the variable temperature water tank and flow into the The temperature of the water in the oxygenator that exchanges heat with the storage fluid is rapidly reduced to 4°C, which in turn allows the donor organ to rapidly cool down to 4°C.
(4)由于所述变温水箱设置在所述控制装置内部，从而大大节省了所述便携式器官捐献供体机械灌注系统的体积，进而提高了携带的便利性。(4) Since the temperature-variable water tank is arranged inside the control device, the volume of the portable mechanical perfusion system for organ donation is greatly saved, thereby improving the convenience of carrying.
上述说明仅是本发明技术方案的概述，为了能够更清楚了解本发明的技术手段，并可依照说明书的内容予以实施，并且为了让本发明的上述和其他目的、特征和优点能够更明显易懂，以下特举较优选实施例，并配合附图，详细说明如下。The above description is only an overview of the technical solution of the present invention, in order to better understand the technical means of the present invention, and to implement it according to the contents of the description, and to make the above and other purposes, features and advantages of the present invention more obvious and understandable , the following particularly preferred embodiments, and with the accompanying drawings, are described in detail as follows.
附图说明Description of drawings
图1为本发明所述的便携式器官捐献供体机械灌注系统的结构示意图；Fig. 1 is a structural schematic diagram of a portable organ donation donor mechanical perfusion system according to the present invention;
其中，图1中的附图标记说明如下：Wherein, the reference numerals in Fig. 1 are explained as follows:
1、控制装置；2、氧合器；3、离心泵；4、血液置换器；5、动脉插管；6、静脉插管；7、氧气源；8、活塞；9、第一三通阀；10、第二三通阀；11、出水端；12、进水端；13、动脉压力传感器；14、静脉压力传感器；15、第三三通阀；16、第四三通阀；17、血氧饱和度传感器；18、第五三通阀；19、流量传感器；20、温度传感器；21、显示屏；22、支架；23、挂钩。1. Control device; 2. Oxygenator; 3. Centrifugal pump; 4. Blood replacement device; 5. Arterial cannula; 6. Venous cannula; 7. Oxygen source; 8. Piston; 9. First three-way valve 10, the second three-way valve; 11, the water outlet; 12, the water inlet; 13, the arterial pressure sensor; 14, the venous pressure sensor; 15, the third three-way valve; 16, the fourth three-way valve; 17, Blood oxygen saturation sensor; 18, the fifth three-way valve; 19, flow sensor; 20, temperature sensor; 21, display screen; 22, bracket; 23, hook.
具体实施方式Detailed ways
为更进一步阐述本发明为达成预期发明目的所采取的技术手段，以下结合附图及较优选实施例，对依据本发明的具体实施方式、结构以及特征，详细说明如下：In order to further elaborate the technical means adopted by the present invention to achieve the desired invention purpose, below in conjunction with the accompanying drawings and preferred embodiments, the specific implementation, structure and features according to the present invention are described in detail as follows:
如图1所示的是本发明所述便携式器官捐献供体机械灌注系统，其包括血液循环氧合闭合装置以及与所述血液循环氧合闭合装置电性连接的控制装置1，并且所述血液循环氧合闭合装置包括氧合器2、离心泵3、血液置换器4、动脉插管5和静脉插管6，其中：As shown in Figure 1 is the portable organ donation donor mechanical perfusion system of the present invention, which includes a blood circulation oxygenation closure device and a control device 1 electrically connected to the blood circulation oxygenation closure device, and the blood The circulatory oxygenation closure device includes an oxygenator 2, a centrifugal pump 3, a blood replacer 4, an arterial cannula 5 and a venous cannula 6, wherein:
所述氧合器2设置有用于连接氧气源7的第一输入端、用于排出二氧化碳的第一输出端、用于连接所述离心泵3输出端的血液输入端以及用于连接所述动脉插管5的血液输出端；The oxygenator 2 is provided with a first input end for connecting the oxygen source 7, a first output end for discharging carbon dioxide, a blood input end for connecting the output end of the centrifugal pump 3, and a blood input end for connecting the arterial plug. the blood output end of the tube 5;
所述离心泵3的输入端与所述静脉插管6相连通；The input end of the centrifugal pump 3 communicates with the venous cannula 6;
所述血液置换器4内设置有可上下移动的活塞8，所述活塞8的上部为用于储存供体血液第一储存端，所述活塞8的下部为用于储存灌注液的第二储存端，所述血液输入端和所述离心泵3的输出端通过第一三通阀9连通所述第一储存端，所述血液输入端和所述离心泵3的输出端通过第二三通阀10连通所述第二储存端。The blood displacer 4 is provided with a piston 8 that can move up and down. The upper part of the piston 8 is the first storage end for storing the donor blood, and the lower part of the piston 8 is the second storage end for storing the perfusate. The blood input end and the output end of the centrifugal pump 3 are connected to the first storage end through the first three-way valve 9, and the blood input end and the output end of the centrifugal pump 3 are connected through the second three-way valve 9. The valve 10 communicates with the second storage port.
当需要对器官进行灌注时，首先将所述第一三通阀9与所述血液输入端之间的管路关闭，然后所述离心泵3开始工作，所述离心泵3的输入口将会产生负压，此时器官内的血液将通过所述静脉插管6被引出到所述第一储存端中，当所述第一存储端中的血液量增加后，所述第一存储端中的压力增加并推动所述活塞8向下移动，此时储存在所述第二储存端中的灌注液将会进入所述氧合器2中与氧气进行结合，同时所述控制装置1控制所述变温水箱中的制冷件开始工作，使得从所述变温水箱中流入到所述氧合器2中与灌注液进行热交换的水的水温迅速降低到4℃，最后结合有氧气的低温灌注液将会依次通过所述血液输出端和所述动脉插管5进入人体，当器官内的血液全部被灌注液替换后即完成灌注，从而使得捐献器官的温度迅速降低，因此，所述便携式器官捐献供体机械灌注系统不需要在开腹后对腹主动脉进行再插管就可以完成低温灌注，较为方便。When it is necessary to perfuse the organ, first the pipeline between the first three-way valve 9 and the blood input port is closed, and then the centrifugal pump 3 starts to work, and the input port of the centrifugal pump 3 will be Negative pressure is generated, at this time, the blood in the organ will be led out to the first storage end through the venous cannula 6, and when the blood volume in the first storage end increases, the blood in the first storage end will The pressure increases and pushes the piston 8 to move downward. At this time, the perfusate stored in the second storage end will enter the oxygenator 2 to combine with oxygen. At the same time, the control device 1 controls the The refrigerating parts in the variable temperature water tank start to work, so that the water temperature of the water flowing into the oxygenator 2 from the variable temperature water tank for heat exchange with the perfusate is rapidly reduced to 4°C, and finally the low temperature combined with oxygen The perfusate will enter the human body sequentially through the blood outlet and the arterial cannula 5, and the perfusion will be completed when all the blood in the organ is replaced by the perfusate, so that the temperature of the donated organ will drop rapidly. Therefore, the portable The donor mechanical perfusion system for organ donation does not require recannulation of the abdominal aorta after laparotomy to complete hypothermic perfusion, which is more convenient.
所述动脉插管5头端设置有球囊，当仅对腹部器官及以下器官进行灌注时，只需要将所述动脉插管5的头端放置到腹腔动脉干以上，对所述球囊充气或注水即可阻断腹腔动脉干以上的腹部主动脉即可，较为方便。The head end of the arterial cannula 5 is provided with a balloon, and when only the abdominal organs and the following organs are perfused, only the head end of the arterial cannula 5 needs to be placed above the celiac artery trunk, and the balloon is inflated Or inject water to block the abdominal aorta above the celiac trunk, which is more convenient.
所述控制装置1内可拆卸连接有带有制冷件的变温水箱，所述氧合器2上还设置有用于连接所述变温水箱出水端11的第二输入端、以及用于连接所述变温水箱进水端12的第二输出端。由于所述变温水箱内设置有制冷件，因而在灌注的过程中，通过所述控制装置1控制所述制冷件工作就可以使从所述变温水箱中流入所述氧合器2中与灌注液进行热交换的水的温度迅速降低至4℃，从而迅速降低被灌注器官的温度。The control device 1 is detachably connected with a temperature-variable water tank with a refrigerating element, and the oxygenator 2 is also provided with a second input end for connecting the water outlet 11 of the variable-temperature water tank, and a second input end for connecting the Describe the second output end of the water inlet end 12 of the variable temperature water tank. Since the temperature-variable water tank is provided with a refrigerating element, during the filling process, the control device 1 can control the operation of the refrigerating element so that it can flow into the oxygenator 2 from the variable-temperature water tank and The temperature of the water in which the perfusate undergoes heat exchange is rapidly reduced to 4°C, thereby rapidly reducing the temperature of the perfused organ.
作为本实施例的一种改进，所述制冷件由半导体材料制成。As an improvement of this embodiment, the cooling element is made of semiconductor material.
所述便携式器官捐献供体机械灌注系统还包括动脉压力传感器13和静脉压力传感器14，并且所述动脉压力传感器13的一端电性连接所述控制装置1，所述动脉压力传感器13的另一端通过第三三通阀15连接在所述血液输出端与所述动脉插管5之间的管路上；所述静脉压力传感器14的一端电性连接所述控制装置1，所述静脉压力传感器14的另一端通过第四三通阀16连接在所述离心泵3的输入端与所述静脉插管6之间的管路上。The portable organ donation donor mechanical perfusion system also includes an arterial pressure sensor 13 and a venous pressure sensor 14, and one end of the arterial pressure sensor 13 is electrically connected to the control device 1, and the other end of the arterial pressure sensor 13 is passed through The third three-way valve 15 is connected on the pipeline between the blood output port and the arterial cannula 5; one end of the venous pressure sensor 14 is electrically connected to the control device 1, and one end of the venous pressure sensor 14 The other end is connected to the pipeline between the input end of the centrifugal pump 3 and the venous cannula 6 through the fourth three-way valve 16 .
具体连接时，所述控制装置1的壳体上设置有用于分别电性连接所述动脉压力传感器13与所述静脉压力传感器14的第一接口和第二接口。In specific connection, the housing of the control device 1 is provided with a first interface and a second interface for electrically connecting the arterial pressure sensor 13 and the venous pressure sensor 14 respectively.
为了能够实时监测血液的血氧饱和度，所述便携式器官捐献供体机械灌注系统还包括血氧饱和度传感器17，所述血氧饱和度传感器17的一端电性连接所述控制装置1，所述血氧度传感器的另一端通过第五三通阀18连接在所述离心泵3的输入端与所述静脉插管6之间的管路上。In order to be able to monitor blood oxygen saturation in real time, the portable organ donation donor mechanical perfusion system also includes a blood oxygen saturation sensor 17, one end of the blood oxygen saturation sensor 17 is electrically connected to the control device 1, so The other end of the blood oxygen sensor is connected to the pipeline between the input end of the centrifugal pump 3 and the venous cannula 6 through the fifth three-way valve 18 .
具体连接时，所述控制装置1的壳体上设置有用于电性连接所述血氧度饱和传感器的第三接口。During specific connection, the housing of the control device 1 is provided with a third interface for electrically connecting the blood oxygen saturation sensor.
所述便携式器官捐献供体机械灌注系统还包括流量传感器19，所述流量传感器19的一端电性连接所述控制装置1，所述流量传感器19的另一端连接在所述离心泵3的输出端与所述血液输入端之间的管路上。The portable organ donation donor mechanical perfusion system also includes a flow sensor 19, one end of the flow sensor 19 is electrically connected to the control device 1, and the other end of the flow sensor 19 is connected to the output end of the centrifugal pump 3 On the pipeline between the blood input port.
具体连接时，所述控制装置1的壳体上设置有用于电性连接所述流量控制器的第四接口。During specific connection, the housing of the control device 1 is provided with a fourth interface for electrically connecting the flow controller.
所述便携式器官捐献供体机械灌注系统还包括温度传感器20，所述温度传感器20的一端电性连接所述控制装置1，所述温度传感器20的另一端连接在所述第一输入端与所述变温水箱出水端11的管路上。The portable organ donation donor mechanical perfusion system also includes a temperature sensor 20, one end of the temperature sensor 20 is electrically connected to the control device 1, and the other end of the temperature sensor 20 is connected to the first input end and the On the pipeline of the water outlet end 11 of the variable temperature water tank.
具体连接时，所述控制装置1的壳体上设置有用于电性连接所述温度传感器20的第五接口。During specific connection, the casing of the control device 1 is provided with a fifth interface for electrically connecting the temperature sensor 20 .
另外，所述血液输入端与所述第一三通阀9之间的管路上设置有微栓过滤器，所述微栓过滤器用于滤除静脉血中的微栓。In addition, a microemboli filter is arranged on the pipeline between the blood input end and the first three-way valve 9, and the microemboli filter is used to filter out microemboli in venous blood.
为了能够在灌注的过程中准确了解各种监测结果，所述控制装置1的壳体上设置有显示屏21，所述显示屏21用于显示所述流量传感器19、所述温度传感器20、所述血氧饱和度传感器17、所述静脉压力传感器14、所述动脉压力传感器13的监测数据。In order to be able to accurately understand various monitoring results during the perfusion process, a display screen 21 is provided on the housing of the control device 1, and the display screen 21 is used to display the flow sensor 19, the temperature sensor 20, the The monitoring data of the blood oxygen saturation sensor 17, the venous pressure sensor 14, and the arterial pressure sensor 13.
为了便于所述血液循环氧合闭合装置的安装与使用，所述便携式器官捐献供体机械灌注系统还包括支架22，所述支架22的顶端设置有用于悬挂所述血液循环氧合闭合装置的挂钩23，具体使用时，所述离心泵3和所述氧合器2均可拆卸连接在所述支架22的下端。In order to facilitate the installation and use of the blood circulation oxygenation closure device, the portable organ donation donor mechanical perfusion system also includes a bracket 22, the top of the bracket 22 is provided with a hook for hanging the blood circulation oxygenation closure device 23. In specific use, both the centrifugal pump 3 and the oxygenator 2 can be detachably connected to the lower end of the bracket 22.
需要说明的是，在本发明的描述中，术语“第一”、“第二”、“第三”、“第四”、“第五”等仅用于描述目的，而不能理解为指示或暗示相对重要性。It should be noted that in the description of the present invention, the terms "first", "second", "third", "fourth", "fifth" and so on are only used for descriptive purposes, and should not be interpreted as indications or imply relative importance.
上述实施方式仅为本发明的优选实施方式，不能以此来限定本发明保护的范围，本领域的技术人员在本发明的基础上所做的任何非实质性的变化及替换均属于本发明所要求保护的范围。The above-mentioned embodiment is only a preferred embodiment of the present invention, and cannot be used to limit the protection scope of the present invention. Any insubstantial changes and substitutions made by those skilled in the art on the basis of the present invention belong to the scope of the present invention. Scope of protection claimed.
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| CN110432260A (en) * | 2019-03-22 | 2019-11-12 | 天一阁医疗科技(广州)有限公司 | A kind of machine perfusion save set of organism organ |
| CN211294426U (en) * | 2019-03-22 | 2020-08-18 | 天一阁医疗科技(广州)有限公司 | Organ perfusion teaching and training system |
| CN112006016A (en) * | 2019-05-31 | 2020-12-01 | 西安赛德欧医疗研究院有限公司 | Room temperature oxygenation perfusion equipment |
| CN110538353A (en) * | 2019-08-19 | 2019-12-06 | 江苏赛腾医疗科技有限公司 | extracorporeal cardiopulmonary support system |
| CN113396898B (en) * | 2021-08-02 | 2021-11-09 | 中山大学附属第一医院 | Organ perfusion device and method without interrupting blood flow |
| CN113813454B (en) * | 2021-08-30 | 2022-09-09 | 四川大学华西医院 | Method for collecting blood of organ donation donor |
| CN114470377A (en) * | 2022-02-10 | 2022-05-13 | 天津汇康医用设备有限公司 | Intelligent ECMO treatment device and control method of system based on rolling blood pump |
| CN116235846B (en) * | 2023-02-27 | 2024-01-30 | 中国科学院苏州生物医学工程技术研究所 | Organ perfusion control method, system and device |
| CN117898283B (en) * | 2023-12-28 | 2025-02-14 | 奇点医疗科技(广州)有限公司 | Device to keep organs alive from non-heart-beating donors |
| CN117547672B (en) * | 2024-01-02 | 2024-04-05 | 中山大学附属第一医院 | DCD-based in-vitro abdominal viscera perfusion and transplantation system |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202459484U (en) * | 2012-02-28 | 2012-10-03 | 中国人民解放军第四军医大学 | Extracorporeal-circulation whole perfusion system |
| CN103886796A (en) * | 2014-03-13 | 2014-06-25 | 西安交通大学 | Organ perfusion system for surgery simulation trainers |
| CN203736601U (en) * | 2014-02-27 | 2014-07-30 | 郭源 | Three-cavity two-balloon arterial perfusion pipe |
| CN203777391U (en) * | 2014-03-09 | 2014-08-20 | 秦喜凤 | Artificial cardiopulmonary system |
| CN203777392U (en) * | 2014-03-09 | 2014-08-20 | 秦喜凤 | Medical extracorporealcirculation system |
| RU2570391C1 (en) * | 2014-06-20 | 2015-12-10 | Общество С Ограниченной Ответственностью "Биософт-М" | Device for extracorporeal mechanical perfusion of donor organs inside donor's body |
| CN205124849U (en) * | 2015-10-13 | 2016-04-06 | 中国人民解放军第三〇九医院 | Separation liver normal atmospheric temperature or low control by temperature change temperature perfusion device |
| CN106689119A (en) * | 2017-02-17 | 2017-05-24 | 南京鼓楼医院 | Isolated organ in vitro perfusion preservation device |
| CN107467011A (en) * | 2017-08-14 | 2017-12-15 | 武汉大学 | A kind of liver oxygen carrying machine perfusion device |
| CN207040657U (en) * | 2017-07-28 | 2018-02-27 | 武汉大学 | A kind of in vitro low temperature oxygen carrying machine perfusion device of toy liver |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2009986B1 (en) * | 2006-03-28 | 2015-04-22 | Organ Assist B.V. | A method and a system for prolongation of the viability of a donor organ |
-
2018
- 2018-06-15 CN CN201810623202.XA patent/CN108432743B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202459484U (en) * | 2012-02-28 | 2012-10-03 | 中国人民解放军第四军医大学 | Extracorporeal-circulation whole perfusion system |
| CN203736601U (en) * | 2014-02-27 | 2014-07-30 | 郭源 | Three-cavity two-balloon arterial perfusion pipe |
| CN203777391U (en) * | 2014-03-09 | 2014-08-20 | 秦喜凤 | Artificial cardiopulmonary system |
| CN203777392U (en) * | 2014-03-09 | 2014-08-20 | 秦喜凤 | Medical extracorporealcirculation system |
| CN103886796A (en) * | 2014-03-13 | 2014-06-25 | 西安交通大学 | Organ perfusion system for surgery simulation trainers |
| RU2570391C1 (en) * | 2014-06-20 | 2015-12-10 | Общество С Ограниченной Ответственностью "Биософт-М" | Device for extracorporeal mechanical perfusion of donor organs inside donor's body |
| CN205124849U (en) * | 2015-10-13 | 2016-04-06 | 中国人民解放军第三〇九医院 | Separation liver normal atmospheric temperature or low control by temperature change temperature perfusion device |
| CN106689119A (en) * | 2017-02-17 | 2017-05-24 | 南京鼓楼医院 | Isolated organ in vitro perfusion preservation device |
| CN207040657U (en) * | 2017-07-28 | 2018-02-27 | 武汉大学 | A kind of in vitro low temperature oxygen carrying machine perfusion device of toy liver |
| CN107467011A (en) * | 2017-08-14 | 2017-12-15 | 武汉大学 | A kind of liver oxygen carrying machine perfusion device |
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