CN108209934B - Auditory sensitivity detection system based on stimulus frequency otoacoustic emission - Google Patents

Abstract

The invention relates to an auditory sensitivity detection system based on stimulation frequency otoacoustic emission. The detection system includes a sound card, an acoustic sensor, a computer and a signal feedback device; the input end of the miniature speaker is connected to the sound card, the output end of the miniature microphone is connected to the sound card, and the signal feedback The device is connected to a computer, and a comprehensive hearing sensitivity detection system is installed in the computer. The test execution system includes an intensity sensitivity detection module based on SFOAEs and a frequency sensitivity detection module based on SFOAEs. The intensity sensitivity detection module based on SFOAEs is used to detect the stimulation of each frequency point. The frequency otoacoustic emission detection data is used to determine the hearing intensity threshold corresponding to the corresponding frequency point; the frequency sensitivity detection module based on SFOAEs is used to extract the stimulation frequency otoacoustic emission suppression tuning curve at the specified frequency point, and determine the frequency sensitivity at the specified frequency point. .

Description

Auditory sensitivity detection system based on stimulus frequency otoacoustic emission

technical field

The invention relates to an auditory detection system, in particular to an auditory sensitivity detection system for objective, quantitative and comprehensive detection of the intensity sensitivity and frequency sensitivity of the auditory system based on stimulation frequency otoacoustic emission.

Background technique

Otoacoustic Emissions (OAEs) is a kind of weak audio energy generated in the cochlea of the inner ear, transmitted through the ossicular chain and tympanic membrane, and released to the external auditory canal. It is a part of the normal function of the human ear. This phenomenon was first discovered by British scholar David Kemp in 1978 and applied clinically. The discovery of otoacoustic emission confirms that the cochlea, as a sensory terminal of hearing, not only passively converts external acoustic signals into bioelectrical signals into the center to induce hearing, but also has an active energy release process, thus establishing that the cochlea is a two-way exchange. energy theory. Since the existence of OAE has become an objective index to evaluate whether the function of the auditory peripheral system is intact, it provides a new concept and research direction for the study of auditory physiology, and its discovery has become one of the important breakthroughs in modern auditory physiology. According to the presence or absence of external stimuli, otoacoustic emissions can be divided into two categories: Spontaneous Otoacoustic Emissions (SOAEs) and Evoked Otoacoustic Emissions (EOAEs). EOAEs can be divided into Transient-Evoked Otoacoustic Emissions (TEOAEs), Distortion-Product Otoacoustic Emissions (DPOAEs) and Stimulus Otoacoustic Emissions (DPOAEs) according to the different evoked stimuli. -Frequency Otoacoustic Emissions, SFOAEs) three categories.

Currently, subjective behavioral response audiometry is used clinically to test auditory threshold strength, such as pure tone audiometry. This method requires subjective cooperation and cannot objectively test infants and young children. However, the clinically used tests for transient evoked otoacoustic emissions (TEOAEs) and distortion product otoacoustic emissions (DPOAEs) can only perform qualitative screening and provide screening results for normal auditory peripheral function, lacking sensitivity to intensity ( Quantitative detection results of hearing threshold). Therefore, there is currently a lack of quantitative, objective and comprehensive detection methods for the intensity sensitivity of the auditory system. In addition, there is no objective, quantitative, and comprehensive detection method for the frequency sensitivity of the auditory system clinically.

Stimulated frequency otoacoustic emissions (SFOAEs) are the active emission of weak sound signals at the same frequency as the stimulating sound after the inner cochlea is stimulated by a signal of a single frequency. Because it can reflect the active mechanism of cochlear outer hair cells, it further reflects the function of the auditory peripheral system. Therefore, stimulated frequency otoacoustic emissions have the potential to objectively, quantitatively, and noninvasively detect auditory system function. Since the frequency of stimulus frequency otoacoustic emission is exactly the same as that of stimulus sound, it is called stimulus frequency otoacoustic emission. The intensity of stimulus frequency otoacoustic emissions is very low, typically between -15dB SPL and +20dB SPL. Its frequency sensitivity at a certain characteristic frequency can be characterized by the Q value of the tuning characteristic represented by the stimulation frequency otoacoustic emission suppression tuning curve. SFOAEs under pure tone stimulation are pure tones with the same frequency as the stimulation sound, so the intensity of SFOAEs has the potential to objectively and quantitatively reflect the hearing threshold at a certain frequency. Because the SFOAEs signal and the stimulation sound signal are completely aliased in the frequency domain; and most of the time, the SFOAEs signal and the stimulation artifact are also aliased in the time domain. In addition, the intensity of the SFOAEs signal is extremely small relative to the intensity of the stimulus sound, usually the intensity of the SFOAEs is about 30dBSPL lower than that of the stimulus sound or even more. Therefore, the use of SFOAEs signals to quantitatively and objectively reflect the threshold of auditory intensity requires more complex detection techniques to suppress stimulus artifacts.

In the prior art, the patent application number 200910237175.3, the invention title is "a portable full-function otoacoustic emission detection system" discloses a portable otoacoustic emission detection system based on a USB multimedia sound card, which is based on the VC++Studio2005 software platform. Full-featured quantitative detection and analysis of transient evoked otoacoustic emissions (TEOAEs) and distorted otoacoustic emissions (DPOAEs) signals. However, this patent does not involve the detection of stimulus frequency otoacoustic emissions, and the use of SFOAEs for the objective quantitative detection of the intensity hearing threshold of the auditory system. At the same time, it does not involve the use of SFOAE STCs for the quantitative detection of the frequency sensitivity of the auditory system. and method; in addition, the patent application number is 201210333260.1, and the name of the invention is "a stimulation frequency otoacoustic emission tuning curve detection and calibration system" only discloses the detection method of the stimulation frequency otoacoustic emission tuning curve and the detection technology of the calibration system, but There are no techniques and methods for the objective and quantitative detection of the intensity hearing threshold of the auditory system using stimulus frequency otoacoustic emissions, nor detailed techniques and methods for quantitative detection of the frequency sensitivity of the auditory system using SFOAE STCs.

SUMMARY OF THE INVENTION

In view of the above problems, the purpose of the present invention is to provide an auditory sensitivity detection system based on stimulation frequency otoacoustic emission, which can not only realize quantitative and objective detection of intensity resolution sensitivity at different frequencies through the test of stimulation frequency otoacoustic emission; Moreover, it can also complete the quantitative and objective detection of the frequency resolution sensitivity at different frequencies through the test of the stimulation frequency otoacoustic emission suppression tuning curve.

In order to achieve the above object, the present invention adopts the following technical solutions: an auditory sensitivity detection system based on stimulation frequency otoacoustic emission, characterized in that the detection system includes a sound card, an acoustic sensor and a computer, wherein the acoustic sensor includes a miniature speaker and a miniature microphone; the computer is provided with a comprehensive hearing sensitivity detection system, including a sound card drive system and a test execution system; the sound card drive system is used to drive the sound card to receive the signal sent by the computer, and through the micro speaker Send to the subject's ear; at the same time drive the sound card to receive the signal sent back by the miniature microphone, and send it to the test execution system; the test execution system includes an intensity sensitivity detection module based on SFOAEs and a SFOAEs-based intensity sensitivity detection module. A frequency sensitivity detection module, the SFOAEs-based intensity sensitivity detection module is used to determine the auditory intensity threshold corresponding to the corresponding frequency point by detecting the stimulation frequency otoacoustic emission data of each frequency point; the SFOAEs-based frequency sensitivity detection module is used for Extract the stimulation frequency otoacoustic emission suppression tuning curve at the specified frequency point, and determine the frequency sensitivity at the specified frequency point.

Further, the intensity sensitivity detection module based on SFOAEs includes a stimulation sound parameter setting module, a suppression sound parameter setting module, a stimulation sound signal generation module, a suppression sound signal generation module, a stimulation sound signal stimulation module, a suppression sound signal stimulation module, a detection Signal acquisition module, signal processing module, frequency domain waveform display module, test data display module, intensity sensitivity conversion module and test result report generation and storage module; the stimulation sound parameter setting module is used for setting stimulation sound frequency, frequency band range, stimulation sound Acoustic frequency test step size and stimulation intensity; the suppression sound parameter setting module is used to set the frequency and intensity of the suppressed sound; the stimulation sound signal generation module and the suppression sound signal generation module respectively generate corresponding digital stimulation sounds according to the set parameters Signal and digital suppression sound signal and send corresponding signals to the stimulation sound signal stimulation module and the suppression sound signal stimulation module; the stimulation sound signal stimulation module and the suppression sound signal stimulation module send the stimulation sound signal and the suppression sound signal through the sound card and a miniature speaker into the subject's ear, the miniature microphone receives the signal sent back from the subject's external auditory canal, amplifies it and sends it to the sound card, and the sound card performs A/D conversion on the signal and sends it to the detection signal acquisition. module, the detection signal acquisition module sends the collected signal to the signal processing module, the signal processing module extracts the stimulation frequency otoacoustic emission under different stimulation frequencies, and sends the detection results to the frequency domain waveform respectively A display module, a test data display module, an intensity sensitivity conversion module and a test result report generation and storage module, the waveform display module dynamically displays the waveforms of amplitude, baseline, phase and noise of the detection data of the SFOAEs at different frequencies; the test The data display module dynamically displays the detection data of SFOAEs at different frequencies, including amplitude, waveform, phase, baseline and noise. Class analysis, and then according to a priori mathematical relationship model, to obtain specific intensity sensitivity values; the test result report generation and storage module is used to generate and save all test results and test information of the subject.

Further, the specific calculation process of the intensity sensitivity conversion module is: according to the signal spectrum appearing at the detection frequency, it is divided into four categories:

The first category: there is no pure audio spectrum or the signal-to-noise ratio is lower than 0dB;

The second category: pure audio spectrum appears and the signal-to-noise ratio is higher than 10dB;

The third category: the presence of pure audio spectrum and the signal-to-noise ratio between 5dB and 10dB;

Category 4: Pure audio spectrum appears and the signal-to-noise ratio is between 5dB-0dB;

For the first category, perform secondary classification. If there is no pure audio spectrum, it is judged that the detection fails, and the detection is performed again or the frequency is changed. For the signal-to-noise ratio lower than 0dB but higher than the baseline 6dB, then the SFOAEs intensity sensitivity = a*( SFOAE amplitude - baseline amplitude), the a value is set according to the frequency;

For the second category, the pure audio spectrum appears and the signal-to-noise ratio is higher than 10dB for secondary classification. For the baseline higher than the noise by more than 3dB, then the SFOAEs intensity sensitivity = b*(SFOAE amplitude - baseline amplitude) + c*(SFOAE baseline Amplitude - noise amplitude), the b and c values are set according to different frequencies; for the baseline greater than the noise value and less than 3dB, the mathematical model of SFOAEs intensity sensitivity = d*(SFOAE amplitude - baseline amplitude), the d value is determined according to the different frequencies. set up;

For the third category, the pure audio spectrum appears and the signal-to-noise ratio is between 5dB and 10dB for secondary classification, for the baseline higher than the noise, then the SFOAEs intensity sensitivity = e*(SFOAE amplitude-f*baseline amplitude), for If the baseline is lower than the noise, the SFOAEs intensity sensitivity=g*(SFOAE amplitude-h*noise amplitude), and the e, f, g, and h values are set according to different frequencies;

For the fourth category, if the pure audio spectrum appears and the signal-to-noise ratio is between 5dB-0dB, the secondary classification is performed. For the baseline higher than the noise, the SFOAEs intensity sensitivity = i*(SFOAE amplitude-j*noise amplitude), For the baseline lower than the noise, the SFOAEs intensity sensitivity=k*(SFOAE amplitude-l*baseline amplitude), the i, j, k, l values are set according to the different frequencies.

Further, the SFOAEs frequency sensitivity detection module includes a stimulation sound parameter setting module, a suppression sound parameter setting module, a stimulation sound signal generation module, a suppression sound signal generation module, a stimulation sound signal stimulation module, a suppression sound signal stimulation module, and a detection signal acquisition module. module, detection signal processing module, SFOAE STCs waveform display module, test data display module, frequency sensitivity conversion module, test result report generation and saving module; the stimulation sound parameter setting module is used for setting stimulation sound frequency and stimulation sound intensity; The suppression sound parameter setting module is used to set the upper limit of the suppression sound frequency, the lower limit of the suppression sound frequency, the step size of the suppression sound frequency and the suppression criterion; the stimulation sound signal generation module and the suppression sound signal generation module generate corresponding digital stimulation according to the set parameters signal and digital suppression signal; the stimulation sound signal stimulation module and the suppression sound signal stimulation module send stimulation sound at the stimulation frequency and suppression sound with different frequencies and intensities to the ear of the subject through the sound card and the micro-speaker to suppress the sound. The frequency of the sensor is adjusted within the range around the stimulation frequency with the set step size of the suppressed sound frequency. The micro microphone amplifies the signal in the ear canal and sends it to the sound card, and finally transmits it to the sound card through the detection signal acquisition module. A detection signal processing module, the detection signal processing module extracts the test results of the SFOAE STCs curve obtained by the stimulation frequency otoacoustic emission at each inhibition frequency within the inhibition acoustic frequency range that satisfies the set inhibition criteria, and the SFOAE STCs waveform display module is used for Display the test waveform; the test data display module dynamically displays the detection data of SFOAE STCs at different frequencies, the frequency sensitivity conversion module groups the detection frequencies, and in each group, according to the amplitude, waveform, baseline and noise of the SFOAE STCs curve Cluster classification is performed, and specific frequency sensitivity values are obtained according to a priori mathematical relationship model; the test result report generation and storage module is used to generate and save all test results and test information of the subject.

Further, the specific calculation process of the frequency sensitivity conversion module is: according to the shape and position of the SFOAE STCs curve appearing at the detection frequency, it is divided into two categories, the first category is the SFOAE STCs curve with double vertices, and the second category is the occurrence of single vertices. SFOAE STCs curves of vertices;

For the first type, the SFOAE STCs curves with double vertices are used for secondary classification. If the apex is higher than the stimulus intensity, the frequency sensitivity = a*Q10+b*high-end slope-c*low-end slope, if the apex is lower than the stimulus sound intensity, then frequency sensitivity=a*Q10;

For the second type of SFOAE STCs curve with a single vertex, if it is shifted to the right, the frequency sensitivity=d*Q10+e*(high-end slope-f*low-end slope), if it is shifted to the left, then the frequency sensitivity=g*Q10 +h*(high-end slope), if there is no offset, then frequency sensitivity=i*Q10, where Q10 refers to the quality factor of 10dB point, according to the detected frequency, select different a, b, c, d, e , f, g and h values.

Further, the detection system also includes a pure-tone audiometry detection module with a resolution of 1dB, and the pure-tone audiometry detection module adopts a subjective behavior method to obtain a hearing threshold with a resolution of 1dB at each frequency point, which is used to compare with the based on the The results of the SFOAEs intensity sensitivity detection module were compared, and the model relationship between the intensity detection based on SFOAEs and the auditory threshold of pure tone audiometry was established.

Further, the detection system also includes a psychophysical tuning curve detection module, and the psychophysical tuning curve detection module adopts a subjective behavior method to obtain the frequency sensitivity at the specified frequency point, for comparing with the result based on the SFOAEs frequency sensitivity detection module , by establishing a model relationship between the frequency sensitivity detection results based on SFOAEs and the frequency sensitivity detection results of PTCs.

Further, the detection system further includes a preamplifier, the input end of the preamplifier is connected to the output end of the miniature microphone, and the output end of the preamplifier is connected to the sound card.

Further, the detection system also includes a signal feedback device, the signal feedback device is connected to the computer for the subject to perform signal feedback and send the subject's feedback result to the computer; the signal feedback device adopts The handle is connected to the computer through a USB interface.

The present invention has the following advantages due to the adoption of the above technical solutions: 1. The test module based on the intensity sensitivity of SFOAEs of the present invention (including the conventional test module and the test module at a specified frequency point) is used to objectively, quantitatively and rapidly extract the set The intensity sensitivity at the frequency point enables the objective detection of auditory thresholds clinically. 2. The test based on the stimulation frequency otoacoustic emission suppression tuning curve (SFOAE STCs) of the present invention realizes quantitative and objective detection of the frequency resolution sensitivity at different frequencies, which is consistent with the psychophysical tuning curves (PTCs) of subjective behavioral responses. By comparing the detected resolution results of the frequency resolution, the quantitative detection of the frequency resolution sensitivity in clinical can be realized. 3. The present invention extracts the weak SFOAEs signal under the condition that the frequency domain and time domain of SFOAEs are mixed with the stimulus sound, and uses the intensity of the SFOAEs signal to objectively and quantitatively reflect the intensity sensitivity (hearing threshold) of the auditory system, Stimulation frequency otoacoustic emission suppression tuning curves (SFOAE STCs) are tuning curves at a certain stimulation frequency, which have the potential to reflect the frequency sensitivity of the cochlea at this frequency. Using SFOAE STCs to objectively and quantitatively reflect the frequency sensitivity of the auditory system, In conclusion, the test of the intensity sensitivity and frequency sensitivity based on SFOAEs of the present invention realizes objective, quantitative, comprehensive and rapid detection of the auditory system, and has a broad prospect of clinical application of hearing.

Description of drawings

Fig. 1 is the overall structure schematic diagram of the present invention;

Fig. 2 is the principle schematic diagram of the test execution system of the present invention;

Fig. 3 is the principle schematic diagram of the intensity sensitivity constant detection module based on SFOAEs of the present invention;

Fig. 4 is the schematic diagram of the frequency sensitivity detection module based on SFOAE STCs of the present invention;

5 is a schematic flow chart of a pure tone audiometry detection module with a resolution of 1dB according to the present invention;

FIG. 6 is a schematic flowchart of the detection module of psychophysical tuning curves (PTCs) of the present invention.

Detailed ways

The present invention will be described in detail below with reference to the accompanying drawings. It should be understood, however, that the accompanying drawings are provided only for a better understanding of the present invention, and they should not be construed to limit the present invention.

As shown in Figure 1, the hearing sensitivity detection system based on stimulation frequency otoacoustic emission provided by the present invention is used to obtain the intensity sensitivity and frequency sensitivity of stimulation frequency otoacoustic emission, including computer 1, sound card 2, acoustic sensor (miniature probe) 3. Preamplifier and signal feedback device; wherein, the acoustic sensor 3 includes a miniature speaker 31 and a miniature microphone 32. In order to isolate the sound in the external auditory canal of the subject from the external sound, the miniature speaker 31 and the miniature microphone 32 can be inserted in the same Inside soft earplugs.

The sound card 2 adopts a multimedia sound card that can be connected with the computer 1, and is used to convert the digital signal sent by the computer 1 into an analog voltage signal. The portable multimedia sound card is connected to the computer 1 through the IEEE1394 interface, for example, but not limited to this, the sound card 2 can also adopt other structural forms and connection methods, such as a multimedia sound card or a common sound card connected to the computer 1 through a USB interface.

The micro-speaker 31 includes two electro-acoustic transducers for generating stimulation sound and suppressing sound respectively, for inducing stimulation frequency otoacoustic emission signals, the two electro-acoustic transducers are inserted into the earplugs through two sound tubes, The input ends of the electro-acoustic transducers are respectively connected to the sound card 2 through two TRS interfaces, which are used to electro-acoustically convert the analog voltage signal into an acoustic signal, which is sent to the subject's ear through the earplugs. Various products in the prior art can be used for the micro-speaker 31, for example, the ER2 plug-in earphone produced by Etymotic Company is used in the detection of the present invention.

The miniature microphone 32 includes an acoustic-electric transducer, which is used to collect otoacoustic emission signals and other signals in the external auditory canal of the human ear, and convert the collected acoustic signals into electrical signals. Set in the earplug, the sound signal in the ear canal is converted into an analog voltage signal by transmitting the sound tube to the acousto-electric transducer, and the output end of the miniature microphone 32 is connected to the input end of the preamplifier. Various products of the prior art can be used for the miniature microphone 32, for example, ER-10B+ produced by Etymotic Company of the United States is used for the detection of the present invention.

The preamplifier is used to amplify the signal output by the miniature microphone 32, and the amplification factor can be adjusted according to actual needs, and the adjustment factor can be selected from 0dB, 20dB and 40dB. In order to avoid the signal interference caused by the ground loop, the preamplifier is powered by two 9V batteries, and the output end of the preamplifier is connected to the sound card 2.

The signal feedback device is connected to the computer 1, and is used for the subject to perform signal feedback and send the subject's feedback result to the computer 1. The signal feedback device can adopt various devices. The signal feedback device of the present invention adopts a handle 4, and the handle 4 passes through Connect the computer 1 with the USB interface.

As shown in FIG. 2 , the computer 1 is provided with an auditory sensitivity comprehensive detection system, including a sound card drive system and a test execution system. The sound card driving system is used to drive the sound card 2 to receive the signal from the computer 1 and send it to the subject's ear through the micro speaker 31; at the same time, the sound card 2 is driven to receive the signal sent back by the preamplifier and send it to the test execution system .

The test execution system includes an intensity sensitivity detection module based on SFOAEs, a frequency sensitivity detection module based on SFOAEs, a pure tone audiometry (PT) detection module with a resolution of 1dB, and a psychophysical tuning curve (PTCs)-based detection module.

The detection module based on the intensity sensitivity of SFOAEs is used to determine the auditory intensity threshold corresponding to the corresponding frequency point by detecting the amplitude, waveform, baseline, phase, and noise of the stimulus frequency otoacoustic emission at each frequency point;

The frequency sensitivity detection module based on SFOAEs is used to extract the stimulation frequency otoacoustic emission suppression tuning curve (SFOAE STCs) at the specified frequency point, and determine the frequency sensitivity at the specified frequency point;

The pure tone audiometry detection module with a resolution of 1dB adopts the subjective behavior method to obtain the hearing threshold with a resolution of 1dB at each frequency point, which is used to compare with the results of the intensity sensitivity detection module based on SFOAEs. The model relationship of the auditory threshold of pure tone audiometry, realizes the intensity sensitivity detection based on SFOAEs that can be consistent with the clinical pure tone audiometry detection results;

The psychophysical tuning curve detection module adopts the subjective behavior method to obtain the frequency sensitivity at the specified frequency point, which is used for comparison with the results of the frequency sensitivity detection module based on SFOAEs, and establishes the frequency sensitivity detection results based on SFOAEs and the frequency sensitivity detection of PTCs in the early stage. The model relationship between the results enables a frequency-sensitive detection of SFOAEs for clinical applications.

In a preferred embodiment, as shown in Figure 3, the intensity sensitivity detection module based on SFOAEs is used to test each frequency, including a stimulus sound parameter setting module, a suppression sound parameter setting module, a stimulus sound signal generation module, and a suppression sound parameter setting module. Signal generation module, stimulation sound signal stimulation module, suppression sound signal stimulation module, detection signal acquisition module, signal processing module, frequency domain waveform display module, test data display module, intensity sensitivity conversion module and test result report generation and storage module. The stimulus sound parameter setting module is used to set the frequency, frequency band range, stimulus sound frequency test step and stimulation intensity of the stimulus sound; the suppression sound parameter setting module is used to set the frequency and intensity of the suppression sound; the stimulus sound signal generation module and the suppression sound signal The generation module generates the corresponding digital stimulation sound signal and digital inhibition sound signal according to the set parameters, and sends the corresponding signals to the stimulation sound signal stimulation module and the inhibition sound signal stimulation module; the stimulation sound signal stimulation module and the inhibition sound signal stimulation module emit stimulation sound The signal and the suppressed sound signal are sent to the subject's ear through the sound card 2 and the micro-speaker 31. The micro-microphone 32 receives the signal sent back from the external auditory canal of the subject, sends it to the preamplifier for amplification, and then sends it to the sound card 2. The signal is A/D converted and sent to the detection signal acquisition module, the detection signal acquisition module sends the collected signal to the signal processing module, the signal processing module extracts the stimulation frequency otoacoustic emission under different stimulation frequencies, and sends the detection results to the frequency Domain waveform display module, test data display module, intensity sensitivity conversion module and test result report generation and saving module. The waveform display module dynamically displays the waveforms of amplitude, baseline, phase and noise of the detection data of SFOAEs at different frequencies; the test data display module dynamically displays the detection data (amplitude, waveform, phase, baseline and noise) of SFOAEs at different frequencies, The intensity sensitivity conversion module is grouped according to the detection frequency; the cluster analysis is performed according to the amplitude, waveform, baseline and noise in each group, and then the specific intensity sensitivity value is obtained according to the prior mathematical relationship model; the test result report generation and storage module Used to generate and save all test results and test information for subjects.

In a preferred embodiment, the intensity sensitivity conversion module performs grouping according to the detection frequency, performs cluster analysis according to amplitude, waveform, baseline and noise in each group, and then obtains specific intensity sensitivity values according to a priori mathematical relationship model , the specific process is:

There are four categories according to the spectrum of the signal present at the detection frequency:

The first category: there is no pure tone signal spectrum or the signal-to-noise ratio is lower than 0dB;

The second category: pure audio spectrum appears and the signal-to-noise ratio is higher than 10dB;

The third category: the presence of pure audio spectrum and the signal-to-noise ratio between 5dB and 10dB;

Category 4: Pure audio spectrum appears and the signal-to-noise ratio is between 5dB-0;

In the first category, the secondary classification is performed. If there is no pure tone signal spectrum, it is judged that the detection fails, and the detection is re-detected or the frequency is changed (which may overlap with SOAE). For the signal-to-noise ratio below 0dB but high If it is 6dB above the baseline, the SFOAEs intensity sensitivity=a*(SFOAE amplitude-baseline amplitude), and the a value is set according to the frequency;

For the second category, the pure audio spectrum appears and the signal-to-noise ratio is higher than 10dB, and then the secondary classification is performed. For the baseline higher than the noise by more than 3dB, then the SFOAEs intensity sensitivity=b*(SFOAE amplitude-baseline amplitude)+c*( SFOAE baseline amplitude - noise amplitude), according to the different detected frequencies, select the appropriate b and c values; for the baseline greater than the noise value less than 3dB, then the mathematical model of SFOAEs intensity sensitivity = d*(SFOAE amplitude - baseline amplitude). According to different detected frequencies, select different d values;

For the third category, the pure audio spectrum appears and the signal-to-noise ratio is between 5dB and 10dB, and then the secondary classification is performed. For the baseline higher than the noise, the SFOAEs intensity sensitivity=e*(SFOAE amplitude-f*baseline amplitude) , for the baseline lower than the noise, then the SFOAEs intensity sensitivity = g * (SFOAE amplitude - h * noise amplitude) According to the different detected frequencies, select different e, f, g, h values;

For the fourth category, the pure audio spectrum appears and the signal-to-noise ratio is between 5dB-0; then the secondary classification is performed, and for the baseline higher than the noise, the SFOAEs intensity sensitivity = i*(SFOAE amplitude-j*noise amplitude) , for the baseline lower than the noise, the SFOAEs intensity sensitivity=k*(SFOAE amplitude-l*baseline amplitude), according to the detected frequency, select different i, j, k, l values

In a preferred embodiment, as shown in FIG. 4 , the SFOAEs frequency sensitivity detection module includes a stimulation sound parameter setting module, a suppression sound parameter setting module, a stimulation sound signal generation module, a suppression sound signal generation module, a stimulation sound signal stimulation module, Suppression acoustic signal stimulation module, detection signal acquisition module, detection signal processing module, SFOAE STCs waveform display module, test data display module, frequency sensitivity conversion module, test result report generation and storage module. The stimulation sound parameter setting module is used to set the stimulation sound frequency and the stimulation sound intensity; the suppression sound parameter setting module is used to set the upper limit of the suppressed sound frequency, the lower limit of the suppressed sound frequency, the step size of the suppressed sound frequency and the suppression criterion; the stimulation sound signal generation module and the suppression sound The acoustic signal generation module generates corresponding digital stimulation signals and digital inhibition signals according to the set parameters; the stimulation acoustic signal stimulation module and the inhibition acoustic signal stimulation module send out stimulation sounds at stimulation frequencies and different frequencies and intensities through the sound card 2 and the micro-speaker 31 . Suppress the sound to the subject's ear, the frequency of the suppressed sound is adjusted within the range around the stimulation frequency with the set suppression sound frequency step size, the micro microphone 32 sends the signal in the ear canal to the sound card 2 through the preamplifier, and finally The detection signal acquisition module is sent to the detection signal processing module, and the detection signal processing module extracts the stimulation frequency otoacoustic emission that meets the set inhibition criteria under each inhibition frequency within the inhibition sound frequency range. Intensity, when the residual amount of stimulation frequency otoacoustic emission reaches the set suppression criterion, stop adjusting, then the point at this time (corresponding suppression frequency point and suppression intensity) is a point in the tuning curve of stimulation frequency otoacoustic emission; The next suppression frequency point is measured by analogy, and connecting each point under different suppression frequencies in the suppression sound frequency range point by point is the test result of the stimulation frequency otoacoustic emission tuning curve, and the SFOAE STCs waveform display module is used to display the test waveform; The test data display module dynamically displays the detection data (amplitude, baseline and noise) of SFOAE STCs at different frequencies; the frequency sensitivity conversion module firstly groups according to the detection frequency; then within each group, according to the amplitude, waveform, baseline of the SFOAE STCs curve Clustering and classification with noise; in different categories, according to the prior mathematical relationship model, the specific frequency sensitivity value is obtained; the test result report generation and storage module is used to generate and save all test results and test information of the subject.

In a preferred embodiment, the frequency sensitivity conversion module is firstly grouped according to the detection frequency; then within each group, cluster classification is performed according to the amplitude, waveform, baseline and noise of the SFOAE STCs curve; in different categories, according to the priori Mathematical relationship model, the specific process of obtaining the specific frequency sensitivity value is as follows:

According to the shape and position of the SFOAE STCs curve appearing at the detection frequency, it is divided into two categories, the SFOAE STCs curve with double apex and the SFOAE STCs with single apex.

For the first type, a double-apex SFOAE STCs curve appears, and then a secondary classification is performed. If the apex is higher than the stimulus sound intensity, then the frequency sensitivity = a*Q10 (10dB point quality factor) + b* high-end slope - c* low end slope, if the vertex is lower than the stimulus intensity, then the frequency sensitivity = a*Q10 (the quality factor of the 10dB point);

2) For the second type of SFOAE STCs curve with a single vertex, if it is shifted to the right, then the frequency sensitivity = d*Q10 (quality factor of 10Db point) + e* (high-end slope-f*low-end slope), if left-biased If there is no offset, then the frequency sensitivity=g*Q10(quality factor of 10Db point)+h*(high-end slope), if there is no offset, then frequency sensitivity=i*Q10(quality factor of 10Db point), according to the detected frequency, Choose different a, b, c, d, e, f, g, and h values.

In a preferred embodiment, as shown in Figure 5, the pure tone audiometry detection module with a resolution of 1dB includes a handle configuration module, a feedback signal receiving module, a test type selection module, a test parameter selection module, a test control analysis module, a pure tone Signal stimulation module, result analysis module and display module; the handle configuration module is used to bind and configure the buttons of the handle 4, and send the binding configuration results to the feedback signal receiving module; the test type selection module is used to select the test type (available for The selected test types include: rising method and rising method); the test parameter selection module is used to set the test method, test frequency and the upper and lower limits of the pure tone intensity; the test control analysis module sends the test frequency and pure tone start according to the selected test method and test parameters. The initial test intensity is sent to the pure tone signal stimulation module, the pure tone signal stimulation module sends a digital pure tone stimulation signal to the subject's ear, and the feedback signal receiving module receives the judgment result fed back by the subject through the handle button, and sends the judgment result back to the test control analysis Module, the test control analysis module increases or decreases the pure tone intensity according to the result, obtains the hearing threshold value under the pure tone signal stimulation, and sends it to the result analysis module for saving or updating, and at the same time judges whether the hearing threshold value of all test frequencies has been obtained. ; If all have been obtained, draw the audiogram and send it to the display module for display. The pure tone audiometry detection module with a resolution of 1dB is used to establish a mathematical model relationship with the strength test results based on SFOAEs in the early large data volume analysis. , to achieve intensity-sensitivity detection based on SFOAEs that is consistent with clinical pure-tone audiometry detection results.

In a preferred embodiment, as shown in FIG. 6 , the detection module based on the psychophysical tuning curve includes a handle configuration module, a test parameter selection module, a test signal generation module, a test control module, a test signal stimulation module, and a feedback signal receiving module , result analysis module and display module; the handle configuration module is used to bind and configure the buttons of the handle 4, and send the binding configuration results to the feedback signal receiving module; the test parameter selection module sets the stimulation sound frequency, stimulation sound intensity and masking sound The upper limit of intensity; the test signal generation module generates pure tone stimulation sound and swept-frequency narrowband masker according to the received test parameters, and sends them to the test control module. Masking sound; the feedback signal receiving module receives the judgment result fed back by the subject through the handle button, and sends the judgment result back to the test control module, which increases or decreases the intensity of the masking sound according to the result, and records the intensity of the masking sound in real time. The value is sent to the result analysis module, and the result analysis module draws the masking sound intensity change map, and performs smoothing and positive and negative average processing to obtain the psychophysical tuning curve, which is sent to the display module for display, based on the psychophysical tuning curve The frequency sensitivity detection module is used to establish a mathematical model relationship with the test results of the suppression tuning curve based on SFOAEs in the early large-scale data analysis, so as to prepare for the detection results of frequency sensitivity based on SFOAE STCs.

In a preferred embodiment, the detection signal acquisition module of the intensity sensitivity detection module based on SFOAEs and the frequency sensitivity detection module based on SFOAEs is the test signal extraction of stimulation frequency otoacoustic emission, and the method for extracting stimulation frequency otoacoustic emission is basically the same, There are mainly three existing methods: nonlinear compression, two-tone suppression, and spectral smoothing, each of which utilizes a different cochlear phenomenon or signal processing technique to extract stimulus-frequency otoacoustic emissions. The method makes full use of the relationship between the compressive increase of the stimulus frequency otoacoustic emission amplitude and the linear increase of the stimulus sound; the method of two-tone suppression is to define the SFOAEs as the ear canal detected by the increase of the inhibitory sound and without the increase of the inhibitory sound near the stimulation frequency. The composite difference between sound pressures, it is believed that suppressing sound can greatly reduce or remove otoacoustic emissions; spectral smoothing is to use a smoothing function to convolve the spectrum of the composite ear canal sound pressure, and its analysis method is to use the stimulation sound and The latency of otoacoustic emission is different, which is equivalent to adding a window in the corresponding latency area.

The above-mentioned embodiments are only used to illustrate the present invention, and the structure, connection method and manufacturing process of each component can be changed to some extent. Any equivalent transformation and improvement based on the technical solution of the present invention should not be used. Excluded from the scope of protection of the present invention.

Claims (8)

1. a hearing sensitivity detection system based on stimulation frequency otoacoustic emission, is characterized in that, this detection system comprises sound card, acoustic sensor and computer, wherein, described acoustic sensor comprises miniature loudspeaker and miniature microphone; In described computer, be provided with Hearing sensitivity comprehensive detection system, including sound card drive system and test execution system; The sound card driving system is used to drive the sound card to receive the signal sent by the computer, and send it to the subject's ear through the micro speaker; at the same time, drive the sound card to receive the signal sent back by the micro microphone, and send it to the test execution system; The test execution system includes an intensity sensitivity detection module based on SFOAEs and a frequency sensitivity detection module based on SFOAEs. The intensity sensitivity detection module based on SFOAEs is used to determine the corresponding frequency point by detecting the stimulation frequency otoacoustic emission data of each frequency point. Corresponding auditory intensity threshold; the frequency sensitivity detection module based on SFOAEs is used to extract the SFOAE STCs curve at the specified frequency point, and determine the frequency sensitivity at the specified frequency point, and the SFOAESTCs curve is the stimulation frequency otoacoustic emission suppression tuning curve; wherein , the frequency sensitivity detection module based on SFOAEs is provided with a frequency sensitivity conversion module, and the specific calculation process of the frequency sensitivity conversion module is: According to the shape and position of the SFOAE STCs curve appearing at the detection frequency, it is divided into two categories, the first category is the SFOAE STCs curve with double vertices, and the second category is the SFOAE STCs curve with single vertices; For the first type, the SFOAE STCs curves with double vertices are used for secondary classification. If the apex is higher than the stimulus intensity, the frequency sensitivity = a*Q10+b*high-end slope-c*low-end slope, if the apex is lower than the stimulus sound intensity, then frequency sensitivity=a*Q10; For the second type of SFOAE STCs curve with a single vertex, if it is shifted to the right, the frequency sensitivity=d*Q10+e*(high-end slope-f*low-end slope), if it is shifted to the left, then the frequency sensitivity=g*Q10 +h*(high-end slope), if there is no offset, then frequency sensitivity=i*Q10, where Q10 refers to the quality factor of 10dB point, according to the detected frequency, select different a, b, c, d, e , f, g and h values. 2. the hearing sensitivity detection system based on stimulation frequency otoacoustic emission as claimed in claim 1, is characterized in that, described intensity sensitivity detection module based on SFOAEs comprises stimulation sound parameter setting module, suppression sound parameter setting module, stimulation sound signal generation module, suppression acoustic signal generation module, stimulation acoustic signal stimulation module, suppressed acoustic signal stimulation module, detection signal acquisition module, signal processing module, frequency domain waveform display module, test data display module, intensity sensitivity conversion module and test result report generation and save module; The stimulation sound parameter setting module is used to set the stimulation sound frequency, the frequency band range, the stimulation sound frequency test step and the stimulation intensity; the suppression sound parameter setting module is used to set the frequency and intensity of the suppression sound; the stimulation sound signal generation The module and the suppression sound signal generation module respectively generate corresponding digital stimulation sound signals and digital suppression sound signals according to the set parameters and send the corresponding signals to the stimulation sound signal stimulation module and the suppression sound signal stimulation module; the stimulation sound signal stimulation module and the suppression sound signal stimulation module sends the stimulation sound signal and the suppression sound signal to the subject's ear through the sound card and the micro-speaker, and the micro-microphone receives the signal sent back from the external auditory canal of the subject, amplifies it, and sends it to the sound card, The sound card performs A/D conversion on the signal and sends it to the detection signal acquisition module, the detection signal acquisition module sends the acquired signal to the signal processing module, and the signal processing module extracts the signals at different stimulation frequencies. Stimulate frequency otoacoustic emission, and send the detection results to the frequency domain waveform display module, test data display module, intensity sensitivity conversion module and test result report generation and storage module, and the waveform display module dynamically displays SFOAEs at different frequencies The waveform of the amplitude, baseline, phase and noise of the detection data under the test data; the test data display module dynamically displays the detection data of SFOAEs at different frequencies including amplitude, waveform, phase, baseline and noise, and the intensity sensitivity conversion module is based on the detection data. The frequency is grouped, and cluster analysis is performed according to the amplitude, waveform, baseline and noise in each group, and then the specific intensity sensitivity value is obtained according to the prior mathematical relationship model; the test result report generation and storage module is used to generate and Save all test results and test information of the subject. 3. the hearing sensitivity detection system based on stimulation frequency otoacoustic emission as claimed in claim 2, is characterized in that, the concrete calculation process of described intensity sensitivity conversion module is: be divided into four categories according to the signal spectrum that occurs at detection frequency: The first category: there is no pure audio spectrum or the signal-to-noise ratio is lower than 0dB; The second category: pure audio spectrum appears and the signal-to-noise ratio is higher than 10dB; The third category: the presence of pure audio spectrum and the signal-to-noise ratio between 5dB and 10dB; Category 4: Pure audio spectrum appears and the signal-to-noise ratio is between 5dB-0dB; For the first category, perform secondary classification. If there is no pure audio spectrum, it is judged that the detection fails, and the detection is performed again or the frequency is changed. For the signal-to-noise ratio lower than 0dB but higher than the baseline 6dB, then the SFOAEs intensity sensitivity = a*( SFOAE amplitude - baseline amplitude), the a value is set according to the frequency; For the second category, the pure audio spectrum appears and the signal-to-noise ratio is higher than 10dB for secondary classification. For the baseline higher than the noise by more than 3dB, then the SFOAEs intensity sensitivity = b*(SFOAE amplitude - baseline amplitude) + c*(SFOAE baseline Amplitude - noise amplitude), the b and c values are set according to different frequencies; for the baseline greater than the noise value and less than 3dB, the mathematical model of SFOAEs intensity sensitivity = d*(SFOAE amplitude - baseline amplitude), the d value is determined according to the different frequencies. set up; For the third category, the pure audio spectrum appears and the signal-to-noise ratio is between 5dB and 10dB for secondary classification, for the baseline higher than the noise, then the SFOAEs intensity sensitivity = e*(SFOAE amplitude-f*baseline amplitude), for If the baseline is lower than the noise, the SFOAEs intensity sensitivity=g*(SFOAE amplitude-h*noise amplitude), and the e, f, g, and h values are set according to different frequencies; For the fourth category, if the pure audio spectrum appears and the signal-to-noise ratio is between 5dB-0dB, the secondary classification is performed. For the baseline higher than the noise, the SFOAEs intensity sensitivity = i*(SFOAE amplitude-j*noise amplitude), For the baseline lower than the noise, the SFOAEs intensity sensitivity=k*(SFOAE amplitude-l*baseline amplitude), the i, j, k, l values are set according to the different frequencies. 4. the hearing sensitivity detection system based on stimulation frequency otoacoustic emission as claimed in claim 1 or 2, is characterized in that, described SFOAEs frequency sensitivity detection module also comprises stimulation sound parameter setting module, suppression sound parameter setting module, stimulation sound signal Generation module, suppression acoustic signal generation module, stimulation acoustic signal stimulation module, suppression acoustic signal stimulation module, detection signal acquisition module, detection signal processing module, SFOAE STCs waveform display module, test data display module, test result report generation and storage module; The stimulation sound parameter setting module is used to set the stimulation sound frequency and the stimulation sound intensity; the suppression sound parameter setting module is used to set the upper limit of the suppressed sound frequency, the lower limit of the suppressed sound frequency, the step size of the suppressed sound frequency and the suppression criterion; the stimulation sound The acoustic signal generating module and the suppressing acoustic signal generating module generate corresponding digital stimulation signals and digital suppressing signals according to the set parameters; The stimulation sound and the suppression sound of different frequencies and intensities are sent to the subject's ears, and the frequency of the suppression sound is adjusted within the range around the stimulation frequency with the set suppression sound frequency step, and the micro-microphone amplifies the signal in the ear canal Then, it is sent to the sound card, and finally sent to the detection signal processing module through the detection signal acquisition module, and the detection signal processing module extracts the stimulation frequency ears that satisfy the set inhibition criteria under each inhibition frequency within the frequency range of the inhibition sound. Acoustic emission obtains the test result of the SFOAE STCs curve, and the SFOAE STCs waveform display module is used to display the test waveform; the test data display module dynamically displays the detection data of the SFOAE STCs at different frequencies, and the frequency sensitivity conversion module is used for the detection frequency. Grouping, clustering and classifying according to the amplitude, waveform, baseline and noise of the SFOAE STCs curve in each group, and obtaining specific frequency sensitivity values according to a priori mathematical relationship model; To generate and save all test results and test information for subjects. 5. the auditory sensitivity detection system based on stimulation frequency otoacoustic emission as claimed in claim 1, it is characterized in that, this detection system also comprises the pure tone audiometry detection module that resolution is 1dB, and described pure tone audiometry detection module adopts subjective behavior The method obtains the hearing threshold with a resolution of 1dB at each frequency point, which is used for comparison with the results of the SFOAEs-based intensity sensitivity detection module, and establishes a model relationship between the SFOAEs-based intensity detection and the hearing threshold of pure tone audiometry. 6. the auditory sensitivity detection system based on stimulation frequency otoacoustic emission as claimed in claim 1, is characterized in that, this detection system also comprises psychophysical tuning curve detection module, and described psychophysical tuning curve detection module adopts subjective behavior method to obtain in The frequency sensitivity at the specified frequency point is used to compare with the results of the frequency sensitivity detection module based on SFOAEs. By establishing a model relationship between the frequency sensitivity detection results based on SFOAEs and the frequency sensitivity detection results of PTCs, PTCs are psychophysical tuning curve. 7. The auditory sensitivity detection system based on stimulation frequency otoacoustic emission as claimed in claim 1, wherein the detection system further comprises a preamplifier, and the input end of the preamplifier is connected to the output end of the miniature microphone, The output end of the preamplifier is connected to the sound card. 8. The auditory sensitivity detection system based on stimulation frequency otoacoustic emission as claimed in claim 6, characterized in that, the detection system further comprises a signal feedback device, and the signal feedback device is connected to the computer for the subject to perform a signal Feedback and send the feedback result of the subject to the computer; the signal feedback device adopts a handle, and the handle is connected to the computer through a USB interface.

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