CN108186900B - A kind of Artemisia annua compound preparation for burn and scald and preparation method thereof - Google Patents

Abstract

The invention discloses a compound preparation of Artemisia annua for burns and scalds and a preparation method thereof. In parts by weight, the compound preparation comprises the following raw materials: Artemisia annua seeds, Burnet, dried blood, rhubarb, frankincense, myrrh, celandine , Comfrey, Bletilla striata, beeswax, borneol and linseed oil, the present invention has obvious analgesic and anti-inflammatory, astringent, antiseptic, promoting the growth of new granulation tissue and reducing scar hyperplasia after burns and scalds.

Description

A kind of Artemisia annua compound preparation for burn and scald and preparation method thereof

technical field

The invention relates to a compound preparation of Artemisia annua for burns and scalds and a preparation method thereof, belonging to the technical field of traditional Chinese medicines.

Background technique

According to the available data, the annual incidence of burns in my country is about 2%, and the total mortality rate is about 1.35/100,000. The causes of burns and scalds are becoming more and more complicated. In addition to common burns such as fire and boiling water, burns from hot pot and motorcycle exhaust pipes have occurred in recent years. Most of them are second- and third-degree injuries, which are not easy to heal, and the incidence rate is on the rise. The survey results of accidental injuries among children aged 0-6 show that burns and scalds ranked second, with a proportion of 13.83%, which is the main cause of injury and disability in children, causing physical and mental developmental disorders in children, and returning to the family and the family. The society brings a heavy economic burden [Li Jiawei, Jing Lin, Xiong Ying, Pan Yujia, Jing Yuan, Lai Qian, Yu Wei. Investigation and Analysis of the Utilization Status of Children's Health Management Services and Children's Health Problems in Rural 0-6 Years Old. Chinese General Medicine, 2014, 17(30): 3590-3593.]. The burns of young people and the elderly are generally life burns, mainly mild to moderate. It is estimated that about 5% of burns in my country require hospitalization, and 95% of minor injuries can be treated at home and outpatient clinics. About 10% of hospitalized burn patients suffer from different degrees of disability, and about 100,000 people with disabilities are newly diagnosed with burns and scalds in my country every year.

Burn wound is the source of complications such as burn infection and organ damage. How to effectively promote wound healing has always been a hot research topic in burn treatment. The drugs used in western medicine to treat burns and scalds are mainly antibiotics. Long-term use will not only cause bacteria to develop drug resistance and induce superinfection, but also reduce the body's immunity. Traditional Chinese medicine has always been a treasure in the field of medicine in the motherland. Traditional Chinese medicine and its preparations are widely used in the treatment of burns and scald, with rapid development and rich dosage forms, which have incomparable advantages over Western medicine; traditional Chinese medicine for burns also shows its uniqueness in anti-infection and promoting wound healing. curative effect. The traditional Chinese medicine formulations commonly used in the treatment of burns are: oil, ointment, powder, film, water solvent, spray, cream, film-forming agent, etc. [Wang Xiaoni, Qiao Bin, Zhou Debin, Zhang Jianchun. Research on Traditional Chinese Medicine Burn Ointment Status and application prospects. Gansu Science and Technology, 2016, 5(32): 124-126.]. Traditional Chinese medicine burn ointment has always occupied a high proportion in traditional Chinese medicine burn medicine due to its convenient and effective advantages.

Pharmacological and clinical trials have proved that traditional Chinese medicine ointment has good curative effect and is one of the most commonly used preparations for external treatment of burns. The ointment and plaster in the external ointment have been used in China for a long time. In the "Carbuncle Chapter" of the "Huangdi Neijing" (Su Wen), there is a record of "sparse the Bianstone and apply the pig ointment". Traditional Chinese medicine burn ointment is mainly suitable for first-degree and second-degree burns. The ointment is viscous and can be applied externally to the affected area, which can not only avoid external irritation and bacterial infection, but also reduce inflammation and pain, improve local blood circulation, and is conducive to the repair and regeneration of wound tissue. in various burn wounds.

SUMMARY OF THE INVENTION

The technical problem to be solved by the present invention is to provide an Artemisia annua compound preparation that has obvious effects of relieving pain, reducing inflammation, astringent, antiseptic, promoting the growth of new granulation tissue and reducing the hyperplasia of scars after burns and scalds.

In order to solve the above-mentioned technical problems, the technical scheme adopted in the present invention is:

A compound preparation of Artemisia annua for burns and scalds, in parts by weight, comprising the following raw materials: Artemisia annua seeds, Burnet, dried blood, rhubarb, frankincense, myrrh, celandine, comfrey, Bletilla striata, beeswax, Borneol and flaxseed oil.

In parts by weight, it contains the following raw materials: 20-30 parts of Artemisia annua seeds, 4-6 parts of Burnet, 2-3 parts of dried blood, 4-6 parts of rhubarb, 0.8-1.2 parts of frankincense, 0.8-1.2 parts of myrrh , Celandine 8-12 parts, Lithospermum 20-30 parts, Bletilla striata 4-6 parts, Beeswax 4-6 parts, Borneol 2-3 parts and Flaxseed oil 70-110 parts.

Among them, Artemisia dalai-lamae is a plant of the order Asterales, Asteraceae, and Artemisia of the genus Artemisia. Aliases: Artemisia Dalai Lama, Artemisia donkey (Gansu, Inner Mongolia), Artemisia annua (Gansu), "Dalai-Shahrir Day" (Mongolian name). It is pungent, bitter, and cold in nature. It has the effects of purging the lungs and calming asthma, removing phlegm and relieving cough, and removing phlegm and reducing swelling. The seeds of Artemisia annua contain glucosinolates (glucosinolates, sinigrin) and fatty oil. The oil extracted is called Artemisia annua oil, which has a certain therapeutic effect on chronic bronchial tubes. Fiber, laxative effect is obvious. "Compendium of Materia Medica": non-toxic. "Tibetan Medicine" Xiangcai Nabao: the above-ground part of the treatment of anthrax "Qinghai-Tibet Medicine". Seeds cure gangrene, relieve stinging pain "Chinese Tibetan Medicine". "Mongolian Medicine" Gongtuge Yiburu, Habubil, Dariya Gan: Seeds are used for gallbladder heat, lung heat, blood heat, botulism, edema, chest fullness, asthma and cough, chest and ribs pain, pulmonary origin heart disease. Its pharmacological effects show that: Artemisia annua seeds have cardiotonic, diuretic, regulating blood lipid, inhibiting inflammatory exudation, antibacterial and anticancer effects. It is clinically used for the treatment of pleural, abdominal and pericardial effusions; for the treatment of pulmonary foamy phlegm and excessive phlegm; for the treatment of pulmonary heart disease and chronic heart failure, as well as for the treatment of chronic heart failure of other heart diseases; for the treatment of joint effusion.

Flaxseed oil is the oil extracted from flaxseed, flaxseed (flaxseed or linseed), also known as flaxseed, is the seed of flax, an annual or perennial herb of the Flax family and the genus Flax. The content of alpha-linolenic acid in flaxseed oil is 53%, which has the functions of anti-tumor, anti-thrombosis, lowering blood lipids, nourishing brain cells, and regulating autonomic nerves; flaxseed oil also contains VE, which is a strong and effective free radical scavenger. It has anti-aging and antioxidant effects; it also contains a considerable amount of higher fatty alcohols, sterols and hydroxyls. Flaxseed oil has the following effects: (1) Delicate and bright skin; (2) Improve arthritis; (3) Improve organ tissue inflammation; (4) Promote cell health; (5) Reduce cholesterol and other effects. Among them, α-linolenic acid and lignans have anti-inflammatory and scar removal effects in burns. Therefore, the linseed oil is not only used as a matrix, but also has a better therapeutic effect in the traditional Chinese medicine formulation.

Celandine (Chelidonium majus) is a species of the genus Chelidonium in the family Papaveraceae. From "Famine Rescue Materia Medica", the whole herb is used as medicine. Cool in nature, bitter in taste; slightly poisonous. Has analgesic, cough, diuretic, detoxification and other effects. Indications: sedative, cough, diuretic, detoxification. Main stomach pain, abdominal pain, enteritis; dysentery, chronic bronchitis, whooping cough, cough, jaundice, edema, ascites, scabies sores, snake bites. "Chinese Medicine Plants": treatment of gastrointestinal pain and ulcers. For external use, it is a scabies medicine and a detumescence medicine, and it is coated with raw juice. Contains a variety of alkaloids, including chelidonine 41%, proto-opioid 22%, human blood oxaline 17%; also contains chelidonic acid, malic acid, citric acid, succinic acid, choline, methylamine, Histamine, tyramine, saponins, flavonols, celandine alcohol, cardiac glycosides, and a lot of vitamin C. The chelidonine contained in it belongs to a class of proto-opioid, which has a strong effect on the peripheral, but weaker on the center, and can paralyze the sensory and motor nerve terminals, but has no effect on the nerve trunk. It is especially suitable for external preparations, and has the effect of reducing swelling and analgesia.

Burnet (Sanguisorba officinalis L.) is a perennial herb of the Rosaceae family. Burnet root is used as medicine, cold in nature, bitter and sour in taste, non-toxic; it belongs to the liver, lung, kidney and large intestine meridians. It has the functions of cooling blood to stop bleeding, clearing heat and detoxifying, cultivating clearing and nourishing yin, reducing swelling and astringing sores. The root contains a variety of tannin components: sanguiin, sanguisorbicaciddilactone, etc.; also contains 2 kinds of galloyl witch hazel sugar derivatives: 5,2'-bis-O-gallic 5,2'-di-O-galloylhamamelose, 2',3,5-tri-O-galloyl-D-furanoylhamamelose. Modern medical research has proved that Diul has the functions of hemostasis and cooling blood, clearing heat and detoxification, astringent and antidiarrheal, and inhibiting various pathogenic microorganisms and tumors. It can treat hematemesis, blood dysentery, burns, eczema, upper gastrointestinal bleeding, ulcer bleeding , blood in the stool, metrorrhagia, tuberculous abscess and chronic osteomyelitis and other diseases. "Compendium" records: Diyu, removes coke heat, and treats blood in stool and stool. To stop bleeding, take the upper section and fry it, the tip of it can bleed, you must know. Yang Shiying said: add Burnet for sores and pain, and Scutellaria for itching. It is recorded in the "Selected Purpose of Materia Medica": Burnet, to stop bleeding, take the upper cut for frying. Use it for blood, take it off and cut it off. To astringe blood, then the same Gui, peony. To clear the heat, then the same return, even. To treat dampness, then the same Gui, Qin. To treat the pain in the blood, then the same Gui, dogwood. To warm the meridians and benefit blood, then the same Gui, ginger. Most of the sour astringent and cold-retracting agent, if it is tonic, it should be guarded, if it is cold, it will coagulate, and if it is warm, it will benefit blood and return to the meridians. "Benjing" also treats golden sores, "Bielu" says to stop pus and blood, aversion to hot sores, it can be used as golden sore paste, which is the function of clearing fire and cooling blood. "Drug Map Examination": Applying decoction for burns, chancre sore canker.

Rhubarb is the dried root and rhizome of Rheum palmatum L., Rheum tanguticumMaxim.ex Balf. or Rheum officinale Baill. of the Polygonaceae plant. Bitter in taste, cold in nature, non-toxic. It has the functions of purging and attacking accumulation, clearing heat and purging fire, cooling blood and detoxifying, promoting blood circulation and removing blood stasis. It is a laxative. It has a strong laxative effect when used raw, and has a slower laxative effect when it is cooked. It is longer than purging fire and detoxifying, clearing dampness and heat; wine making is good at activating blood, and is good at clearing the blood of Shangjiao; stir-fried charcoal is often used for cooling Bleeding to stop bleeding. It is used for the treatment of intestinal stagnation, constipation, epistaxis due to blood heat, red eyes, sore throat, swollen gums, heat-toxic sores, water-fire scalds, blood stasis amenorrhea, traumatic injuries, damp-heat jaundice, and hot stranguria. "Compendium of Materia Medica": governance soup fire injury. Using rhubarb to study and apply honey, not only relieve pain, but also eliminate scars [http://zhongyaocai360.com/]. Rhubarb contains anthraquinone glycosides, and also contains nearly 40% calcium oxalate, and other components are emodin, gum, resin, rhein, rhubarb epoxidation, and astringent rhubarb tannin. The main modern pharmacological effects are: (1) Effects on the digestive system: (1) Diarrhea effect: by stimulating the mucosa of the large intestine, the peristalsis is increased and diarrhea; in addition, it can also inhibit the Na+, K+-ATPase on the intestinal cell membrane and hinder the transport of Na+ It increases the osmotic pressure in the intestine, retains a lot of water, and promotes peristalsis and diarrhea; ② promotes the gallbladder and protects the liver; ③ promotes the secretion of pancreatic juice and inhibits the activity of pancreatic enzymes; ④ resists gastric and duodenal ulcers. (2) Effects on the blood system: ① hemostasis; ② lowering blood lipids. (3) Anti-infection effects: ① anti-pathogenic microorganisms; ② anti-inflammatory and antipyretic effects; ③ immune regulation; ④ anti-aging and antioxidant effects.

Comfrey (Lithospermumerythrorhizon Sieb.et Zucc.) is the dried root of a perennial herb of the genus Lithospermaceae. Nature and taste: bitter, cold. Functions and indications: cooling blood, promoting blood circulation, clearing heat, detoxifying. Indications: Warm rash, damp-heat jaundice, purpura, vomiting, epistaxis, hematuria, stranguria, constipation due to heat, burns, eczema, erysipelas, carbuncle ulcers. "Medicinal Properties": "Treat malignant sores and tinea." Main chemical components: Comfrey root contains naphthoquinone derivatives and fatty acids. Naphthoquinone derivatives include shikonin (Shikonin, Shikonin), acetyl shikonin (Acetylshikonin), deoxyshikonin (Deoxyshikonin), isobutyl shikonin (Isobutyshi-konin), isovaleryl shikonin Isovalerylshikonin, β, β-dimethylacryloyl shikonin (β, β-Dimethyla-crylshikonin), etc.; fatty acids are mainly palmitic acid, oleic acid and linoleic acid. Pharmacological effects: (1) Antibacterial and anti-inflammatory effects: Comfrey has an inhibitory effect on Jingke 68-1 virus in vitro, and can also inhibit Staphylococcus aureus and Lingobacter. The tincture of comfrey from the former Soviet Union has inhibitory effects on pyogenic bacteria and Escherichia coli; it can accelerate epithelial growth and treat burns. (2) Influence on the circulatory system. (3) Anti-tumor effect. (4) Contraceptive effect. (5) Other effects: Xinjiang soft comfrey decoction has a mild antipyretic effect on rabbits, and has an unstable excitatory effect on the isolated uterus and small intestinal smooth muscle of rabbits. Oral decoction can strengthen the tension and contraction of the small intestine. Injections have no such reaction. Comfrey leaf extract can reduce blood sugar in rabbits and increase intestinal tension in guinea pigs.

Dried blood (Daemonorops draco Bl.) is processed from the resin exuded from the fruit of Draconis dactyloides, a palm plant. It has the functions of promoting blood circulation and relieving pain, removing blood stasis and stopping bleeding, astringing sores and promoting muscle growth. For bruises, confidant stasis pain, traumatic bleeding, sores and ulcers do not converge. "Compendium of Materia Medica": tonic, and blood, astringent sores. Sweet and salty. Red into the blood. Supplements the pericardium and liver blood deficiency, removes blood pain, disperses stasis and regenerates, and is the holy medicine for reconciling blood. Governs internal injury and blood gathering, gold sore collapse, sore incompatibility, pain relief and muscle regeneration. Impatient, do not use too much, and induce pus (blood dried blood alone enters the blood component, frankincense, myrrh also enter the qi component, all of which are lignans). Out of the South. The color is red, and it is true that the nails are dyed through (the false one is the blood of the sea mother, the taste is salty, and there is a fishy smell). It is used for single grinding (the same medicine is pounded, then it is used as dust fly) [http://zhongyaocai360.com/]. The chemical composition is: dracorubin, dracorhodin, nordracorubin, nordracorhodin, (2S)-5-methoxy- 6-Methylflavan-7-ol, (2S)-5-methoxypolygan-7-ol, 2,4-dihydroxy-5-methyl-6-methoxyurone, Dracula Alkane (dracoflavan) A, dracooxepine, pimaric acid, isopimaric acid, abietic acid, dehydroabietic acid, mountain Dapimaric acid (sandaracopimaricacid). Pharmacological effects are: antifungal effect, hemostatic effect. With myrrh, its power of promoting blood circulation and breaking blood stasis is enhanced, and it is used for bruises, blood stasis, swelling and pain. With frankincense, it promotes blood circulation and promotes muscle growth, and also astringes sores and stretches tendons, so it can be used for malignant sores and carbuncles, long-term non-removal of mouths, bleeding from golden sores, and incompatibility of wounds.

Frankincense (Boswellia carteri.) is the resin exuded from the bark of the olive plant Boswellia carterii Birdw. and Boswellia bhaurdajiana Birdw. Pungent, bitter, warm in nature. It has the effect of promoting blood circulation, relieving pain, reducing swelling and promoting muscle growth. Indications: chest pain and heartache, epigastric pain, dysmenorrhea, amenorrhea, postpartum stasis, abdominal pain due to Zhengjia, rheumatic arthralgia, muscle spasm, traumatic injury, carbuncle, swollen and sore. "Compendium of Materia Medica": eliminate carbuncle various poisons, protect the heart, promote blood circulation and relieve pain, treat women with dystocia and fractures. Frankincense frankincense channeling, can enter the heart meridian, activate blood circulation and relieve pain, so it is an essential medicine for carbuncle sores and confidant pain. ... obstetrics and various prescriptions are used for many purposes, and they are also used for their blood-activating effects. "Famous Doctors": "Treat Fengshui toxin and swollen, remove bad qi." "Treat wind-addicted prurigo." The chemical composition is: resin 60%-70%, gum 27%-35%, volatile oil 3%-8%. The main components of the resin are free a, β-boswellic acid (a, β-boswellic acid) 33%, combined boswellic acid 13.5%; mastic resin hydrocarbon (olibanoresene) 33%; gum is arabic acid (arabic acid) Calcium and magnesium salts of 20%, astragalus glue (bassorin) 6%. In addition, it still contains 0.5% bitterness and volatile oil. The main pharmacological effects are: (1) Analgesic effect: It was proved by mouse hot plate method that frankincense volatile oil has analgesic effect, and the residue after extracting volatile oil is invalid. The analgesic in volatile oil is mainly n-octyl acetate. (2) Anti-inflammatory and antiseptic effect: Frankincense can promote the increase of polynuclear leukocytes to phagocytose dead blood cells and cells, improve metabolism, and thus play an anti-inflammatory effect. Combined with myrrh, realgar, etc., it can reduce swelling and regenerate muscles, and it is a ministerial medicine.

Myrrha (Commiphora myrrha Engl.) is the dry resin of Commiphora myrrha Engl. or Commiphora molmol Engl. of the olive family tree. Pungent, bitter, flat in nature. It has the effect of dispersing blood stasis and calming pain, reducing swelling and promoting muscle growth. Commonly used for the treatment of chest pain, epigastric pain, dysmenorrhea, amenorrhea, postpartum stasis, abdominal pain due to Zhengjia, rheumatic arthralgia, traumatic injury, carbuncle, swollen sore and other diseases. The chemical composition is: α-bisadol and β-heerabomyrrholic acid, α-bisabolic acid, β-bisabolic acid and γ-bisabolic acid, Commiphorinic acid , α-Hempabolol and β-Hempabolol (α-Heerabomyrrhol, β-Heerabomyrrhol), Heeraboresene; also contains volatile oil, the components of which are eugenol, m-phenol, citral , Cinnamaldehyde, Heerabolene, etc. The pharmacological effects are: (1) Myrrh water infusion has inhibitory effect on dermatophytes such as Trichophyton violaceum; (2) The volatile oil of myrrh can also slightly inhibit dermatophytes; (3) Myrrh can also reduce the incidence of Blood cholesterol levels in mice and chickens, and have anti-inflammatory effects. "Compendium of Materia Medica": frankincense activating blood, myrrh dispersing blood, all can relieve pain, reduce swelling, and build muscle, so the two medicines are used in each phase.

Baiji (Bletilla striata (Thunb.) Reichb.F.) is also known as Lianhecao, Gangen, Baijie, Ruolan, Zhulan ("Flowering Mirror"), purple orchid, Zihui, and Baili. It is a perennial herbaceous bulbous plant (root tuber). A good medicine for hemostasis, bitter in nature, sweet and astringent, slightly cold, non-toxic. Function convergence and hemostasis, swelling and muscle regeneration. Indications of internal and external trauma bleeding. For hemoptysis and hematemesis, traumatic hemorrhage, sore swelling and toxin, chapped skin; pulmonary tuberculosis hemoptysis, ulcer bleeding. Tubers mainly contain bibenzyl compounds, dioxyphenanthrene compounds, biphenanthrene compounds, bisphenanthrene compounds, dihydrophenanthropyrans, phenanthrene derivatives with spironolactone, phenanthrene glycosides, and other phenanthrenes Compounds, benzyl compounds, anthracene compounds, acid components, aldehyde components; fresh tubers additionally contain bletillamannan. "Shen Nong's Materia Medica": "maintains carbuncle, malignant sore, gangrene, injures yin dead muscle, and evil qi in the stomach." "Compendium of Materia Medica": "The smell (root) is bitter, flat, and non-toxic." Ethnic medicine: 【WA Medicine] Baiji, Baiji: bulbs are used for tuberculosis hemoptysis, gastrointestinal bleeding, scalds, burns "Zhongwa Medicine". [Yi medicine] Dabaiji: tuberous root to treat pulmonary tuberculosis, hemoptysis, bleeding from gold wounds, scalds and burns, and cracked hands and feet. Pseudobulbs are used for fractures of hands and feet. Arturopo: Treatment of tuberculosis, whooping cough, bronchiectasis, silicosis, acute perforation of gastric and duodenal ulcers, tuberculous atrophy, burns and surgical trauma, anal fissures, etc. [Mulao Medicine] Big stammer: Tuber treats internal and traumatic injuries from "Gui Yao Bian". [Jingpo Medicine] Lahoiban: It is used in the "Dehong Medicine Record" of the same Deang people. Shop on credit: rhizomes are used for tuberculosis, bronchiectasis, hemoptysis, hematemesis in gastric ulcer, hematuria, blood in the stool, traumatic hemorrhage, burns, impotence. [Local Medicine] Ruoke (rofkevyler): rhizomes treat pulmonary tuberculosis, hemoptysis, blood in the stool, chapped skin, burns, and scalds "Tujia Medicine".

Beeswax, also known as yellow wax, beeswax. Beeswax is a fatty substance secreted by 4 pairs of wax glands in the abdomen of worker bees of appropriate age in the colony. Sweet, lukewarm. Has astringent, astringent sores, muscle regeneration, pain relief, conditioning. Externally used for ulcers that do not converge, ecthyma erosion, wounds, burns and scalds. Often made into pharmaceutical excipients and ointment base. Its main components can be divided into 4 categories, namely esters, free acids, free alcohols and hydrocarbons; in addition, it also contains trace amounts of volatile oils and pigments; it is said that it still contains an aromatic colored substance called insect wax. (Cerolein). Pharmacological effects: (1) Active ammonia scavenging effect; (2) Other effects, beeswax and its emulsion have bacteriostatic and antiseptic effects. "Materia Medica Tongxuan": paste the sore muscle and relieve pain. "Benjing": the main pus and blood in diarrhea, invigorating the middle, continuing the injury, golden sore, benefiting qi. In "Medical Forest Collection", "Wang Zhongmian's Experience Prescriptions", and "Qianjin Yifang", there are records of treating decoction for burns and sores.

Borneol, also known as borneol ("Bie Lu"), brain ("Over the Sea"), borneol ("Bencao Jing"), Plum Blossom Brain ("Children's Medicine Syndrome Zhi Jue"), Plum Blossom Pian Nao ("Yijian") Zhi"), Pian Nao ("Shou Yu Shen Fang"), Plum Blossom Nao, Born Pian Nao ("Outline"), Plum Pian, Mei Bing. It is obtained by steam distillation and recrystallization from the stems and leaves of Aina incense, or the branches and leaves of Lauraceae. The air is fragrant, pungent, bitter, slightly cold in nature. It has the functions of clearing the orifices and refreshing the mind, clearing heat and dispelling toxins, improving eyesight and relieving nebula. It is mainly used to treat febrile diseases, high fever, dizziness, stroke, phlegm convulsions, epilepsy, heat-dampness, blindness and clear orifices, throat obstruction, deafness, aphthous and swollen teeth, sores and carbuncles. chancre hemorrhoids, red eyes, swelling and pain, nebula covering the eyes. In Liaoning's "Selected Materials of the New Medical Law of Chinese Herbal Medicine", it is recorded that borneol is used to treat scald and burns. "Medical Forest Compilation": "Borneol mainly disperses stagnation fire, can penetrate bone heat, treat epilepsy, phlegm, throat paralysis, tongue swelling, toothache, deafness, snoring, red eyes and nebula, pox invagination, and insecticide. , hemorrhoids, procreation, and non-observation of sex, it can also generate muscle and relieve pain. However, it is easy to be exhausted, and it is ultimately cold." Clinical application: (1) Treatment of pediatric burns: A total of 216 cases were treated, of which 46 cases passed the systematic comparison Observation showed that the average healing days for superficial second-degree burns were about 10 days, and the average healing days for deep second-degree burns were about 24 days. (2) Treatment of ulcerative stomatitis. (3) Treatment of chronic rhinitis. (4) Treatment of suppurative otitis media. (5) Treatment of enterobiasis. (6) Treatment of chronic bronchitis, etc.

The dosage form of the Artemisia annua preparation is a paste.

A preparation method for the compound preparation of Artemisia annua for burns and scald, comprising the following concrete steps:

(1) take by weighing the wormwood seeds of the formula and bake in a preheated container, stir-fry quickly until there is a popping sound, cool the roasted wormwood seeds, pulverize, and set aside for subsequent use;

(2) after taking by weighing the dried blood, rhubarb and charcoal of the formula amount, pulverize, sieve, for subsequent use;

(3) after taking by weighing the frankincense and myrrh of the formula quantity and pulverizing, sieve for subsequent use;

(4) take by weighing the celandine of formula amount, adopt 80% ethanol extraction, and the filtrate is concentrated to extract, for subsequent use;

(5) after taking by weighing the comfrey and Bletilla striata of the formula amount and pulverizing, add an appropriate amount of linseed oil and heat, filter while hot, and get the filter oil for subsequent use;

(6) take by weighing the Burnet of the formula amount and bake in the preheated container, bake until the charred yellow, let the roasted Burnet cool, pulverize, sieve, for subsequent use;

(7) get the Burnet powder in step (6), the beeswax of formula amount and add in the filtered oil boiled in step (5) and stir, cooling, add the dried blood powder in step (2) and the borneol of formula amount, stir Until the borneol dissolves, put it at room temperature for later use;

(8) Take the frankincense powder and myrrh powder in step (3), add an appropriate amount of linseed oil and mix, add it and the rhubarb powder in step (2) to the standby material in step (7), stir evenly, and set aside for later use ;

(9) the Artemisia annua powder in step (1) is joined in the remaining linseed oil, mixes, obtains Artemisia annua paste for subsequent use;

(10) Add the celandine extract in step (4) and the rice wormwood paste prepared in step (9) to the standby materials in step (8), and stir evenly to obtain a reddish-brown paste preparation.

In step (1), the preheating temperature is 100° C., and the baking is performed for 3-5 seconds.

In step (3), frankincense and myrrh were baked at 120° C. for 2 hours, cooled to room temperature, and then pulverized.

The powders in steps (2), (3) and (6) are all passed through a 100-mesh sieve.

In step (4), celandine was extracted twice by refluxing with 80% ethanol, the first extraction was 2 hours, the second extraction was 1.5 hours, filtered respectively, and the filtrates were combined.

In step (5), the linseed oil is heated to 115° C., and the heating time is 30 min.

In step (7), the temperature is lowered to 56° C., and then the dried blood powder in step (2) and the borneol in the formula amount are added.

Beneficial effects achieved by the present invention: In the present invention, Artemisia annua seeds are used for the first time in a traditional Chinese medicine preparation for treating burns and scalds, and they are used in combination with other traditional Chinese medicines or traditional Chinese medicine extracts to promote the therapeutic effect, and are made into pastes , has the characteristics of uniformity, ductility, adsorption, fiber-forming and hygroscopicity, and moderate viscosity.

Description of drawings

Fig. 1 is a comparison chart of the therapeutic effect after control group, Artemisia annua unilateral oil preparation and Artemisia annua compound paste are administered to mice in the embodiment;

Figure 2 is a comparison diagram of skin pathological sections after the normal skin of mice, the control group, the single oil preparation of Artemisia annua and the compound paste of Artemisia annua are administered to the mice in the embodiment.

Detailed ways

The present invention will be further described below in conjunction with the accompanying drawings. The following examples are only used to illustrate the technical solutions of the present invention more clearly, and cannot be used to limit the protection scope of the present invention.

1. A kind of rice wormwood single oil preparation for burns and scalds

The main raw materials are: Artemisia annua seeds 20g, linseed oil 30ml.

Preparation method: (1) Take 20 g of Artemisia annua seeds, put them on a tile preheated to 100°C and bake for 3-5 seconds, and at the same time stir-fry quickly until there is a popping sound;

(2) the roasted Artemisia seeds is quickly transferred into the white porcelain plate and allowed to cool, and is ground into powder in a mortar;

(3) Take 30ml of linseed oil, add it to the ground rice wormwood powder, mix it into a light brown-yellow oily paste, and set aside.

2. A rice wormwood compound paste for burns and scalds

The main raw materials are: Artemisia annua seeds 25g, Burnet 5g, Draconis 2.5g, Rhubarb 5g, Frankincense 1g, Myrrh 1g, Celandine 10g, Comfrey 25g, Bletilla striata 5g, Beeswax 5g, Borneol 2.5g, Flaxseed oil About 90ml.

Preparation method: (1) Place the seeds of Artemisia annua on a tile preheated to 100° C. and bake for 3-5 seconds, and at the same time quickly stir-fry until there is a popping sound;

(2) the roasted Artemisia seeds are quickly poured into a white porcelain plate and allowed to cool, and ground into powder in a mortar, for subsequent use;

(3) dried blood, rhubarb stir-fried with carbon, ground into powder; pass through a 100-mesh sieve respectively, for use;

(4) Bake frankincense and myrrh at 120°C for 2 hours, cool to room temperature, grind into powder, pass through a 100-mesh sieve, and set aside for later use;

(5) Take 10 g of celandine, extract with 80% ethanol under reflux for 2 hours, and filter to obtain a filtrate; filter residues with 80% ethanol under reflux for extraction for 1.5 hours, filter, combine the filtrates, and concentrate to extract;

(6) respectively take 25g of pulverized comfrey, 5g of Bletilla striata, add 50ml linseed oil, heat at 115 DEG C for 30min, filter while hot to obtain filter oil, for subsequent use;

(7) Burnet is dried, ground, and passed through a 100-mesh sieve; 5 g of Burnet powder and 5 g of beeswax are added to the boiled oil filter (6), stirred, placed at 56°C, and 2.5 g of dried blood powder, borneol are added respectively. 2.5g, stir until the borneol dissolves; leave at room temperature for later use;

(8) respectively get frankincense powder 1g, myrrh powder 1g, join in 10ml linseed oil and mix well; add 5g of rhubarb powder to (7) again, stir well, standby;

(9) Heat 25g of Artemisia argyi powder into 30ml of linseed oil, mix well, and obtain Artemisia argyi paste for subsequent use;

(10) The celandine concentrate prepared in (5) and the rice wormwood paste prepared in (9) were added to (8), and after stirring and mixing, a reddish-brown paste preparation was obtained.

3. Burn and scald modeling experiment

3.1. Experimental subjects

BALB/c mice. Half male and half female, with an average weight of 18-22g, and kept at clean level.

3.2. Experimental materials

LKTC-L, CONTROLLE constant temperature water bath (Jintan District Xicheng Xinrui Instrument Factory), surgical tweezers, scissors, 10g weight (Xiangyi Balance Instrument Factory), timer, string, epilator.

3.3. Model preparation

The constant temperature water bath was heated to 100°C and kept at a constant temperature. The 10g weight tied with the string was placed in the water bath and preheated for about 10 minutes. The back of the mouse was depilated with an epilator. After ether anesthesia, the back was treated with the preheated weight After scalding for 5 s, the same part was scalded twice in a row, and a circular scalded area with a diameter of 1 cm was scalded on the back of the mouse, which was a grade II scald.

3.4. Model drug delivery

Mice were randomly divided into 3 groups, namely the control group, the single oil preparation group of Artemisia annua and the compound paste group of Artemisia annua. Cotton swabs were used to apply medicine to the scalded area in the morning, noon and evening, three times a day. The back skin of mice in the control group was smeared with linseed oil as an adjunct every day, and the same operation was performed as in the medication group. Mice were sacrificed 7 days after administration, and the damaged skin tissue and surrounding normal skin tissue were collected, fixed in 4% paraformaldehyde for 2 days, embedded in paraffin, and stained with HE for histological observation.

4. Therapeutic effect

As shown in Figure 1, it is a comparison of the therapeutic effects of the control group, the single oil preparation of Artemisia annua L. and the compound paste of Artemisia annua L. , the cell morphology was blurred and mutated, and partial necrosis appeared at the same time, and the color was white and red and swollen, which formed a sharp contrast with the normal tissue in the surrounding area. The effect of the paste is obviously better than that of the Artemisia annua single oil. The scalded skin begins to form scabs on the 2nd day after treatment with the compound paste; after 4 days of application, a thick layer of dark purple-red dry scabs is formed, and the tissue swelling is significantly reduced at the same time; After 6 days of medication, the dark purple-red dry scab became dry, and the scab on the edge of the scalded area lifted up; after 7 days of medication, there was ingrowth of granulation tissue around, and there was still a thick layer of dry scab on the tissue, and the wound area was significantly reduced .

As shown in Figure 2, for the normal skin of mice, the control group, the single oil preparation of Artemisia annua and the compound paste of Artemisia annua were administered to the mice with skin pathological sections, observed under histomorphological microscope, and compared with the normal mouse skin tissue, The scalded skin structure of the mice in the control group had coagulation necrosis, and the epidermis and dermis were severely damaged; some tissues fell off, and the scalded depth reached the deep dermis, showing the characteristics of deep second-degree scald; the mice in the treatment group were treated for 7 days, and the scalded skin tissue hierarchy Recovery, the recovery of skin structure after treatment with Mihao compound paste was significantly better than that in Mihao single oil group. The structure of sweat glands and hair follicle glands is basically restored, the epidermis hierarchy is becoming more and more complete, the skin is in a state of recovery, and the epidermis is almost complete.

The above are only the preferred embodiments of the present invention. It should be pointed out that for those skilled in the art, without departing from the technical principle of the present invention, several improvements and modifications can also be made. These improvements and modifications It should also be regarded as the protection scope of the present invention.

Claims (8)

1. a compound preparation of Artemisia annua for burns and scalds, is characterized in that, in parts by weight, is made of following raw materials: 20-30 parts of Artemisia annua seeds, 4-6 parts of Burnetia chinensis, 2-3 parts of dried blood parts, 4-6 parts of rhubarb, 0.8-1.2 parts of frankincense, 0.8-1.2 parts of myrrh, 8-12 parts of celandine, 20-30 parts of comfrey, 4-6 parts of Bletilla striata, 4-6 parts of beeswax, 2 parts of borneol -3 servings and 70-110 servings of linseed oil; The preparation method of described Artemisia annua compound preparation comprises the following specific steps: (1) take by weighing the wormwood seeds of the formula and bake in a preheated container, stir-fry quickly until there is a popping sound, cool the roasted wormwood seeds, pulverize, and set aside for subsequent use; (2) after taking by weighing the dried blood, rhubarb and charcoal of the formula amount, pulverize, sieve, for subsequent use; (3) after taking by weighing the frankincense and myrrh of the formula quantity and pulverizing, sieve for subsequent use; (4) take by weighing the celandine of formula amount, adopt 80% ethanol extraction, and the filtrate is concentrated to extract, for subsequent use; (5) after taking by weighing the comfrey and Bletilla striata of the formula amount and pulverizing, add an appropriate amount of linseed oil and heat, filter while hot, and get the filter oil for subsequent use; (6) take by weighing the Burnet of the formula amount and bake in the preheated container, bake until the charred yellow, let the roasted Burnet cool, pulverize, sieve, for subsequent use; (7) get the Burnet powder in step (6), the beeswax of formula amount and add in the filtered oil boiled in step (5) and stir, cooling, add the dried blood powder in step (2) and the borneol of formula amount, stir Until the borneol dissolves, put it at room temperature for later use; (8) Take the frankincense powder and myrrh powder in step (3), add an appropriate amount of linseed oil and mix, add it and the rhubarb powder in step (2) to the standby material in step (7), stir evenly, and set aside for later use ; (9) the Artemisia annua powder in step (1) is joined in the remaining linseed oil, mixes, obtains Artemisia annua paste for subsequent use; (10) Add the celandine extract in step (4) and the rice wormwood paste prepared in step (9) to the standby materials in step (8), and stir evenly to obtain a reddish-brown paste preparation. 2. a kind of Artemisia annua compound preparation for burn and scald according to claim 1, is characterized in that, described Artemisia annua preparation dosage form is paste. 3. A kind of Artemisia annua compound preparation for burn and scald according to claim 1, is characterized in that, in step (1), the preheating temperature is 100 DEG C, and bakes for 3-5 seconds. 4. a kind of Artemisia annua compound preparation for burn and scald according to claim 1 is characterized in that, in step (3), frankincense and myrrh are placed at 120 DEG C and baked for 2h, cooled to room temperature, and then pulverized. 5. a kind of Artemisia annua compound preparation for burn and scald according to claim 1, is characterized in that, in step (2), (3) and (6), powder all passes 100 mesh sieves. 6. a kind of Artemisia annua compound preparation for burn and scald according to claim 1, is characterized in that, in step (4), celandine is extracted twice with 80% ethanol reflux, the first time is extracted 2h, the second time The extraction was carried out for 1.5h, respectively, and the filtrates were combined. 7. a kind of Artemisia annua compound preparation for burn and scald according to claim 1, is characterized in that, in step (5), linseed oil is heated to 115 ℃, and the heating time is 30min. 8. a kind of Artemisia annua compound preparation for burn and scald according to claim 1 is characterized in that, in step (7), be cooled to 56 ℃, then add the dried blood powder in step (2) and the Ice flakes.

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