CN108159103B - A kind of Artemisia annua preparation for burn and scald and preparation method thereof - Google Patents

Abstract

The invention discloses an Artemisia annua preparation for burns and scalds and a preparation method thereof. The preparation formula comprises the following raw materials: Artemisia annua seeds and auxiliary materials, wherein the auxiliary materials are preferably linseed oil. , astringent, antiseptic, promoting the growth of new granulation tissue and reducing the effect of scarring after burns.

Description

A kind of Artemisia annua preparation for burn and scald and preparation method thereof

technical field

The invention relates to an Artemisia annua preparation used for burns and scalds and a preparation method thereof, belonging to the technical field of traditional Chinese medicines.

Background technique

According to the available data, the annual incidence of burns in my country is about 2%, and the total mortality rate is about 1.35/100,000. The causes of burns and scalds are becoming more and more complicated. In addition to common burns such as fire and boiling water, burns from hot pot and motorcycle exhaust pipes have occurred in recent years. Most of them are second- and third-degree injuries, which are not easy to heal, and the incidence rate is on the rise. The survey results of accidental injuries among children aged 0-6 show that burns and scalds ranked second, with a proportion of 13.83%, which is the main cause of injury and disability in children, causing physical and mental developmental disorders in children, and returning to the family and the family. The society brings a heavy economic burden [Li Jiawei, Jing Lin, Xiong Ying, Pan Yujia, Jing Yuan, Lai Qian, Yu Wei. Investigation and Analysis of the Utilization Status of Children's Health Management Services and Children's Health Problems in Rural 0-6 Years Old. Chinese General Medicine, 2014, 17(30): 3590-3593.]. The burns of young people and the elderly are generally life burns, mainly mild to moderate. It is estimated that about 5% of burns in my country require hospitalization, and 95% of minor injuries can be treated at home and outpatient clinics. About 10% of hospitalized burn patients suffer from different degrees of disability, and about 100,000 people with disabilities are newly diagnosed with burns and scalds in my country every year.

Burn wound is the source of complications such as burn infection and organ damage. How to effectively promote wound healing has always been a hot research topic in burn treatment. The drugs used in western medicine to treat burns and scalds are mainly antibiotics. Long-term use will not only cause bacteria to develop drug resistance and induce superinfection, but also reduce the body's immunity. Traditional Chinese medicine has always been a treasure in the field of medicine in the motherland. Traditional Chinese medicine and its preparations are widely used in the treatment of burns and scald, with rapid development and rich dosage forms, which have incomparable advantages over Western medicine; traditional Chinese medicine for burns also shows its uniqueness in anti-infection and promoting wound healing. curative effect. The traditional Chinese medicine formulations commonly used in the treatment of burns are: oil, ointment, powder, film, water solvent, spray, cream, film-forming agent, etc. [Wang Xiaoni, Qiao Bin, Zhou Debin, Zhang Jianchun. Research on Traditional Chinese Medicine Burn Ointment Status and application prospects. Gansu Science and Technology, 2016, 5(32): 124-126.]. Traditional Chinese medicine burn ointment has always occupied a high proportion in traditional Chinese medicine burn medicine due to its convenient and effective advantages.

Pharmacological and clinical trials have proved that traditional Chinese medicine oil and ointment have good curative effect and are one of the most commonly used preparations for external treatment of burns. The ointment and plaster in the external ointment have been used in China for a long time. In the "Carbuncle Chapter" of the "Huangdi Neijing" (Su Wen), there is a record of "sparse the Bianstone and apply the pig ointment". Traditional Chinese medicine burn ointment is mainly suitable for first-degree and second-degree burns. The ointment is viscous and can be applied externally to the affected area, which can not only avoid external irritation and bacterial infection, but also reduce inflammation and pain, improve local blood circulation, and is conducive to the repair and regeneration of wound tissue. in various burn wounds.

SUMMARY OF THE INVENTION

The technical problem to be solved by the present invention is to provide an Artemisia annua preparation with obvious analgesic, anti-inflammatory, astringent, anti-corrosion, promotion of new granulation tissue growth and reduction of scar hyperplasia for burns and scalds.

In order to solve the above-mentioned technical problems, the technical scheme adopted in the present invention is:

A preparation of Artemisia annua for burns and scalds comprises the following raw materials: Artemisia annua seeds and auxiliary materials.

The adjuvant is preferably linseed oil, and can also be other vegetable fats or animal fats commonly used in burn and scald medicines, or other adjuvants required for preparation of other dosage forms, such as ointments, powders, films, and the like.

Among them, Artemisia dalai-lamae is a plant of the order Asterales, Asteraceae, and Artemisia of the genus Artemisia. Aliases: Artemisia Dalai Lama, Artemisia donkey (Gansu, Inner Mongolia), Artemisia annua (Gansu), "Dalai-Shahrir Day" (Mongolian name). It is pungent, bitter, and cold in nature. It has the effects of purging the lungs and calming asthma, removing phlegm and relieving cough, and removing phlegm and reducing swelling. The seeds of Artemisia annua contain glucosinolates (glucosinolates, sinigrin) and fatty oil. The oil extracted is called Artemisia annua oil, which has a certain therapeutic effect on chronic bronchial tubes. Fiber, laxative effect is obvious. "Compendium of Materia Medica": non-toxic. "Tibetan Medicine" Xiangcai Nabao: the above-ground part of the treatment of anthrax "Qinghai-Tibet Medicine". Seeds cure gangrene, relieve stinging pain "Chinese Tibetan Medicine". "Mongolian Medicine" Gongtuge Yiburu, Habubil, Dariya Gan: Seeds are used for gallbladder heat, lung heat, blood heat, botulism, edema, chest fullness, asthma and cough, chest and ribs pain, pulmonary origin heart disease. Its pharmacological effects show that: Artemisia annua seeds have cardiotonic, diuretic, regulating blood lipid, inhibiting inflammatory exudation, antibacterial and anticancer effects. It is clinically used for the treatment of pleural, abdominal and pericardial effusions; for the treatment of pulmonary foamy phlegm and excessive phlegm; for the treatment of pulmonary heart disease and chronic heart failure, as well as for the treatment of chronic heart failure of other heart diseases; for the treatment of joint effusion.

Flaxseed oil is the oil extracted from flaxseed, flaxseed (flaxseed or linseed), also known as flaxseed, is the seed of flax, an annual or perennial herb of the Flax family and the genus Flax. The content of alpha-linolenic acid in flaxseed oil is 53%, which has the functions of anti-tumor, anti-thrombosis, lowering blood lipids, nourishing brain cells, and regulating autonomic nerves; flaxseed oil also contains VE, which is a strong and effective free radical scavenger. It has anti-aging and antioxidant effects; it also contains a considerable amount of higher fatty alcohols, sterols and hydroxyls. Flaxseed oil has the following effects: (1) Delicate and bright skin; (2) Improve arthritis; (3) Improve organ tissue inflammation; (4) Promote cell health; (5) Reduce cholesterol and other effects. Among them, α-linolenic acid and lignans have anti-inflammatory and scar removal effects in burns. Therefore, the linseed oil is not only used as a matrix, but also has a better therapeutic effect in the traditional Chinese medicine formulation.

In parts by weight, the amount of the Artemisia annua seeds is 10-30 parts, and the amount of the linseed oil is 15-45 parts.

The Artemisia annua preparation is an oil preparation.

A preparation method of Artemisia annua preparation for burns and scalds, comprising the following concrete steps:

(1) Take an appropriate amount of wormwood seeds and bake them in a preheated container, and stir-fry quickly until there is a popping sound;

(2) let the roasted Artemisia seeds cool, grind into powder;

(3) Take an appropriate amount of linseed oil, add the ground rice wormwood powder, and mix it into a paste.

In step (1), the preheating temperature is 100° C., and the heating time is 3 to 5 seconds.

Beneficial effects achieved by the present invention: in the present invention, Artemisia annua seeds are used for the first time in a traditional Chinese medicine preparation for treating burns and scalds, and they are used in combination with linseed oil. Post-pain, preventing infection of the scalded area, and promoting wound healing are all helpful. In particular, flaxseed oil is rich in alpha-linolenic acid and lignans, which can reduce inflammation and eliminate scars. Together, the two can promote the therapeutic effect. .

Description of drawings

Fig. 1 is the treatment effect diagram after giving medicine to people in the embodiment;

Fig. 2 is the treatment effect comparison diagram after giving mice medicine in the embodiment;

Figure 3 is a comparison diagram of skin pathological sections after administration to mice in the Example.

Detailed ways

The present invention will be further described below in conjunction with the accompanying drawings. The following examples are only used to illustrate the technical solutions of the present invention more clearly, and cannot be used to limit the protection scope of the present invention.

1. A kind of rice wormwood single oil preparation for burns and scalds

The main raw materials are: Artemisia annua seeds 20g, linseed oil 30mL.

Preparation method: (1) Take 20 g of Artemisia annua seeds, put them on a tile preheated to 100°C and bake for 3-5 seconds, and at the same time stir-fry quickly until there is a popping sound;

(2) the roasted Artemisia seeds is quickly transferred into the white porcelain plate and allowed to cool, and is ground into powder in a mortar;

(3) Take 30 mL of linseed oil, add it to the ground rice wormwood powder, and mix it into a light brown-yellow oily paste for later use.

2. Burn and scald modeling experiment

2.1. Experimental subjects

BALB/c mice. Half male and half female, with an average weight of 18-22g, and kept at clean level.

2.2. Experimental materials

LKTC-L, CONTROLLE constant temperature water bath (Jintan District Xicheng Xinrui Instrument Factory), surgical tweezers, scissors, 10g weight (Xiangyi Balance Instrument Factory), timer, string, epilator.

2.3. Model preparation

The constant temperature water bath was heated to 100°C and kept at a constant temperature. The 10g weight tied with the string was placed in the water bath and preheated for about 10 minutes. The back of the mouse was depilated with an epilator. After ether anesthesia, the back was treated with the preheated weight After scalding for 5 s, the same part was scalded twice in a row, and a circular scalded area with a diameter of 1 cm was scalded on the back of the mouse, which was a grade II scald.

2.4. Model drug delivery

The mice were randomly divided into 2 groups, namely the control group and the single-sided Artemisia annua oil group. The scalded area was smeared with cotton swabs in the morning, noon and evening, three times a day. The back skin of mice in the control group was smeared with linseed oil as an adjunct every day, and the same operation was performed as in the medication group. Mice were sacrificed after 7 days of administration, and the injured skin and surrounding normal skin were removed, fixed in 4% paraformaldehyde for 2 days, embedded in paraffin, and stained with HE for histological observation.

3. Therapeutic effect

As shown in Figure 1, in order to give the therapeutic effect after the administration, the skin surface was red, swollen, bruised, and locally ulcerated for 2 days; after 3 days of administration, scabs began to form. Reduced; after 5 days of medication, the exudation was significantly reduced, but the edge inflammation was still obvious; after 7 days of medication, the scab had formed a complete and stable structure, and then the medication was stopped. After 51 days, the skin's epidermis and dermis tend to recover.

As shown in Figure 2, for the comparison of the therapeutic effect after administration to the mice, it was observed that: the skin wounds of the mice in the control group had scalded ulceration, severe tissue swelling, blurred cell morphology, and some skin tissue after 4-7 days. Necrosis, the color was white and red and swollen, which was in sharp contrast with the normal tissue in the surrounding area. After 4 days of treatment in the mice in the treatment group, a layer of red-purple dry scab was formed on the wound surface; after 6 days of treatment, a thick layer of dark purple was formed. Red dry scab; after 7 days of medication, the wound shrunk, surrounded by granulation tissue ingrowth, and there was still a thick scab on the tissue.

As shown in Figure 3, for the comparison of skin pathological sections after administration to mice, observed under histomorphological microscope, compared with normal mouse skin tissue, the scalded skin structure of mice in the control group had coagulation necrosis, and the epidermis and dermis structure The injury was serious; some tissues fell off, and the scalded depth reached the deep dermis, showing the characteristics of deep second-degree scald; after 7 days of treatment in the mice in the medication group, the structure of the scalded skin was clear, and the accumulation of mast cells and macrophages was accompanied by fibroblasts. , Collagen is generated, the deep structure is gradually restored, the epidermis hierarchy is becoming more and more complete, and the skin is in a state of recovery.

The above are only the preferred embodiments of the present invention. It should be pointed out that for those skilled in the art, without departing from the technical principle of the present invention, several improvements and modifications can also be made. These improvements and modifications It should also be regarded as the protection scope of the present invention.

Claims (3)

1. an artemisia preparation for burn and scald, is characterized in that, is made of following raw material: Artemisia annua seed and auxiliary material; The auxiliary material is linseed oil; In parts by weight, the amount of the Artemisia annua seeds is 10-30 parts, and the amount of the linseed oil is 15-45 parts; The preparation method of the Artemisia annua preparation comprises the following specific steps: (1) Take the wormwood seeds of the formula and bake in a preheated container, and stir-fry quickly until there is a popping sound; (2) let the roasted Artemisia seeds cool, grind into powder; (3) Take the linseed oil of the formula amount, add the ground rice wormwood powder, and mix it into a paste. 2. a kind of Artemisia annua preparation for burn and scald according to claim 1, is characterized in that, described Artemisia annua preparation is oil. 3. A kind of Artemisia annua preparation for burn and scald according to claim 1, is characterized in that, in step (1), the preheating temperature is 100 DEG C, and the heating time is 3～5 seconds.

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