CN108135739A - Device for lowering intraocular pressure and method for manufacturing such a device - Google Patents
Device for lowering intraocular pressure and method for manufacturing such a device Download PDFInfo
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- CN108135739A CN108135739A CN201680058955.XA CN201680058955A CN108135739A CN 108135739 A CN108135739 A CN 108135739A CN 201680058955 A CN201680058955 A CN 201680058955A CN 108135739 A CN108135739 A CN 108135739A
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- control apparatus
- flow control
- housing
- filter
- aqueous humor
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
An apparatus for reducing/stabilizing intraocular pressure is provided. A tube extends from the inlet end in fluid communication with the anterior chamber of the eye to direct a flow of aqueous humor from the anterior chamber to an outlet end in fluid communication with a cavity defined by the housing for receiving the aqueous humor. A flow control device is operably engaged with the housing and configured to control a location of a conduit through which aqueous humor flows defined and extending from the cavity away from the anterior chamber. The catheter is expandable in response to the intraocular pressure being above a preselected pressure to increase flow or to decrease resistance to flow of aqueous humor through the catheter to the drainage side and to reduce the intraocular pressure to no greater than the preselected pressure. Associated apparatus and methods are also provided.
Description
Technical field
All aspects of this disclosure generally relate to aqueous humor draining into the position outside anterior chamber or remote from the anterior chamber of eyes
Position from anterior chamber more particularly relates to use flow control apparatus for reducing the device and method of intraocular pressure
The implantable devices of intraocular pressure are adjusted, which has expansible conduit, for guiding outside the anterior chamber of eyes
The aqueous humor in portion flow to outer side or distal drainage side, for reducing and adjusting intraocular pressure.
Background technology
Glaucoma is one group of chronic optic nerve disease and the main reason for is irreversible blindness.Main wind in glaucoma
Dangerous factor is since from eyes, undeservedly drain aqueous humor leads to raised intraocular pressure.It is by reducing in optic nerve to reduce intraocular pressure
On pressure prevent the therapy of unique empirical tests of the development of visual loss.
For reducing the operation for glaucoma of the standard of intraocular pressure, such as trabeculectomy and glaucoma drainage device implantation become
Then it is very long and traumatic, there is uncertain result and the complication rate of 20-60%.Implantable drainage system be used for from
The aqueous humor of ocular drainage excess, and the installation of this drainage system usually requires that and operation opening is caused on sclera to reach eyes
Inside, be specifically anterior chamber or back room.Then, drainage system is inserted into the inside of eyes for aqueous humor is directed to conjunctiva
Down space (wherein this device in the text be referred to as conjunctiva under current divider) or to the outside of conjunctiva (in wherein this device in the text
Referred to as external splitters).
Problem associated with current divider under conjunctiva is the possible scarring of bubble in subconjunctival space, influences it and is exporting
The formation of surrounding annulus capsule, this requires the operation amendment for leading to additional complication risk in many cases.Accordingly, there exist right
In identification and utilize the ongoing research for substituting the problem of drainage side is associated with to avoid many with bubble and fibrous capsule formation.
External splitters avoid bubble and fibrous capsule formed and in subconjunctival space wound healing unpredictability.
However, the outlet of external splitters, particularly those on anterior corneal surface may be by patients as foreign matter.These current dividers
Also it can move to shift or wound healing process by shrinking is squeezed out by local organization.Additionally, external splitters meeting
Expose mechanical pipe, which can be used for microorganism being transported to the inside of eyes from outside, potentially result in inverse
The sexy dye of row.
All drainage systems being implanted in eyes have the possibility blocked by the protein in aqueous humor or other materials.
It blocks the permeability for reducing device and intraocular pressure may be caused to be increased compared to baseline.In addition, no matter the effect of drainage system
Fruit, intraocular pressure can naturally change or fluctuate due to the aqueous humor dynamic in specific eyes.
For previous reasons, exist and leave the anterior chamber of eyes for being used to guide aqueous humor for reducing and manage intraocular pressure
Improved drainage system demand.
Invention content
Above and other requirement is met by all aspects of this disclosure, on the one hand the disclosure is proposed for from ocular drainage aqueous humor
For reducing or stablizing the equipment of intraocular pressure, wherein, eyes include anterior chamber, cornea, the corneal limbus surrounded and under eyelid
Eyes external ocular, by the corneal limbus surrounded, cornea is continuous with Scleral shell and conjunctiva layer.This equipment can include
The pipe fitting extended between arrival end and the port of export, wherein arrival end are suitable for the anterior chamber of eyes being in fluid communication, and its middle pipe
Part is suitable for guiding flow of aqueous humor from anterior chamber and passes through arrival end to the port of export.Housing limits what is be in fluid communication with the port of export of pipe fitting
Chamber, wherein, which is configured to receive aqueous humor.Flow control apparatus is operationally engaged with housing, and is constructed and come from order to control
Position outside chamber to anterior chamber or the flow of aqueous humor of the position far from anterior chamber.The flow control apparatus be limited to chamber and external position it
Between the conduit that connects, wherein, intraocular pressure that conduit may be in response to more than the pressure being pre-selected and expand, with increase flow or
To reduce the resistance flowed to the aqueous humor by conduit to external position, and it is reduced to intraocular pressure and is not more than what is be pre-selected
Pressure.
On the other hand the disclosure proposes to manufacture to reduce or stablize intraocular pressure from ocular drainage aqueous humor
The method of equipment, wherein, eyes include the external ocular of anterior chamber, cornea, the corneal limbus surrounded and the eyes under eyelid, lead to
The corneal limbus surrounded is crossed, cornea is continuous with Scleral shell and conjunctiva layer.This method includes engaging the port of export of pipe fitting
It is in fluid communication with the chamber limited by housing, wherein, the port of export extends to the arrival end suitable for being in fluid communication with the anterior chamber of eyes, and
And wherein the pipe fitting is suitable for guiding from anterior chamber and passes through arrival end and the flow of aqueous humor to the port of export so that aqueous humor is connect by chamber
It receives.Distensible flow control apparatus is engaged with housing, wherein, distensible flow control apparatus is suitable for control flow of aqueous humor from chamber
Position outside to anterior chamber or the position to separate anterior chamber, and wherein, which is limited to chamber and external position
Between the conduit that connects, intraocular pressure that conduit may be in response to more than the pressure being pre-selected and expand, to increase flow or subtract
Small resistance to being flowed by the aqueous humor of conduit to external position and so that intraocular pressure is reduced to what is be pre-selected no more than this
Pressure.
The disclosure also has the equipment on the one hand proposed for reducing or stablizing intraocular pressure from ocular drainage aqueous humor,
In, eyes include the external ocular of anterior chamber, cornea, the corneal limbus surrounded and the eyes under eyelid, pass through the cornea surrounded
Edge, cornea are continuous with Scleral shell and conjunctiva layer.This equipment is included in the pipe fitting extended between arrival end and the port of export,
Middle arrival end is suitable for being in fluid communication with the anterior chamber of eyes, and wherein pipe fitting is suitable for flow of aqueous humor is guided from anterior chamber and to pass through entrance
Hold the port of export.Flow control apparatus is operationally engaged with housing, and is constructed in order to control outside pipe fitting to anterior chamber
The flow of aqueous humor of position.The flow control apparatus is limited to the conduit connected between the port of export and external position, wherein, conduit can be rung
Intraocular pressure of the Ying Yu more than the pressure being pre-selected and expand, to increase flow or to reduce to by conduit to external position
Aqueous humor flowing resistance, and intraocular pressure is made to be reduced to no more than the pressure that is pre-selected.First filter device is arranged
To be in fluid communication between the arrival end and flow control apparatus of pipe fitting, wherein, filter for installation is configured in flowing control dress
Pollutant of the filtering from aqueous humor before putting.Second filter for installation be arranged as with flow control apparatus be in fluid communication, with from
The port of export of the pipe fitting of flow control apparatus is opposite, wherein, the second filter for installation is configured to filtering from any to flowing control
The pollutant of the reflux of device processed.
Therefore, the disclosure includes following embodiment with not having limitation：
Embodiment 1：It is a kind of to be used for from ocular drainage aqueous humor for reducing or stablizing the equipment of intraocular pressure, before eyes have
Room and the external ocular for including cornea, the corneal limbus surrounded and the eyes under eyelid pass through the corneal limbus cornea surrounded
It is continuous with Scleral shell and conjunctiva layer, which is included in the pipe fitting extended between arrival end and the port of export, and arrival end is suitable for
It is in fluid communication with the anterior chamber of eyes, and pipe fitting is suitable for guiding from anterior chamber and passes through the flow of aqueous humor of arrival end to the port of export；
Housing, limits the chamber being in fluid communication with the port of export of pipe fitting, which is configured to receive aqueous humor；And flow control apparatus, with housing
The flow of aqueous humor of the position outside chamber to anterior chamber in order to control is operatively engaged and constructs, which is limited to
The conduit connected between chamber and external position, intraocular pressure which may be in response to more than the pressure being pre-selected and expand,
To increase flow or to reduce the resistance to the flowing of the aqueous humor by conduit to external position and so that intraocular pressure drops to
No more than the pressure being pre-selected.
Embodiment 2：The equipment or combination of any aforementioned or aftermentioned embodiment, including filter for installation, filter dress
It puts and is arranged as being in fluid communication between the arrival end and flow control apparatus of pipe fitting, filter for installation is configured in flowing control dress
Pollutant of the filtering from aqueous humor before putting.
Embodiment 3：The equipment or combination of any aforementioned or aftermentioned embodiment, wherein, filter for installation is with housing in pipe
It is engaged after the port of export of part, and wherein, housing is constructed so as to be operatively engaged the flow control apparatus of engagement with it
It is removable or interchangeable relative to housing, so as to which filter for installation be allowed to be removed and replaced.
Embodiment 4：The equipment or combination of any aforementioned or aftermentioned embodiment, including filter for installation, filter dress
It puts and is arranged as being in fluid communication with flow control apparatus, the filter opposite with the port of export of the pipe fitting from flow control apparatus
Device is configured to filter the pollutant from any reflux to flow control apparatus.
Embodiment 5：The equipment or combination of any aforementioned or aftermentioned embodiment, wherein, filter for installation is controlled in flowing
It is engaged after device with housing, and wherein, the filter for installation that housing is constructed so as to be engaged with it is relative to housing can
It removes or interchangeable.
Embodiment 6：The equipment or combination of any aforementioned or aftermentioned embodiment, wherein, flow control apparatus is limited to chamber
The multiple conduits connected between external position, and wherein, at least one of conduit is distensible.
Embodiment 7：The equipment or combination of any aforementioned or aftermentioned embodiment, wherein, each conduit be provided parallel to and
It is connected between chamber and external position.
Embodiment 8：The equipment or combination of any aforementioned or aftermentioned embodiment, wherein, conduit is included with being limited by housing
The single ingress port that is in fluid communication of chamber and respectively pass through the corresponding channel fluid that extends from ingress port company with ingress port
Logical multiple outlet ports.
Embodiment 9：The equipment or combination of any aforementioned or aftermentioned embodiment, wherein, channel from single ingress port to
Extend to outer radial so that each outlet port is angularly spaced around ingress port.
Embodiment 10：The equipment or combination of any aforementioned or aftermentioned embodiment, wherein, flow control apparatus includes first
Part and second part, the single ingress port that first part limits and is in fluid communication by the chamber that housing limits, and second part
Multiple outlet ports are limited, first part and second part are configured to complementally engage to limit liquid storage between them
Device, and each outlet port is connected with ingress port via the reservoir fluid.
Embodiment 11：The equipment or combination of any aforementioned or aftermentioned embodiment, wherein, second part be it is rigid so as to
It resists in response to the deformation for the power for being applied to it.
Embodiment 12：The equipment or combination of any aforementioned or aftermentioned embodiment, wherein, flow control apparatus is configured to ring
Additional, distensible conduit therein should be formed in the output of laser aid.
Embodiment 13：The equipment or combination of any aforementioned or aftermentioned embodiment, wherein, flow control apparatus is configured to ring
The conduit thus limited should be sealed in the output of laser aid.
Embodiment 14：The equipment or combination of any aforementioned or aftermentioned embodiment, wherein, housing is constructed so that can with it
The flow control apparatus operatively engaged is removable or interchangeable relative to housing.
Embodiment 15：The equipment or combination of any aforementioned or aftermentioned embodiment, wherein, flow control apparatus be arranged in by
The intracavitary that housing limits.
Embodiment 16：The equipment or combination of any aforementioned or aftermentioned embodiment, wherein, housing limits and from pipe fitting
The opposite hole of the flow control apparatus of the port of export, the hole are in fluid communication with chamber so as to which aqueous humor be allowed to flow out to outer position by it
It puts.
Embodiment 17：The equipment or combination of any aforementioned or aftermentioned embodiment, wherein, catheter configurations is may be in response to
The intraocular pressure below pressure that is pre-selected and shrink, to reduce flow or increase to the aqueous humor by conduit to external position
The resistance of flowing and so that intraocular pressure is increased to no more than the pressure that is pre-selected.
Embodiment 18：The equipment or combination of any aforementioned or aftermentioned embodiment, further includes and is operationally engaged with housing
Anchoring device, which is configured to engage eyes under conjunctiva so that housing at least is fastened to eyes.
Embodiment 19：The equipment or combination of any aforementioned or aftermentioned embodiment, wherein, catheter configurations for it is normal narrow with
Aqueous humor is avoided to flow through it.
Embodiment 20：The equipment or combination of any aforementioned or aftermentioned embodiment, wherein, flow control apparatus is by biofacies
Capacity materials are formed.
Embodiment 21：The equipment or combination of any aforementioned or aftermentioned embodiment, wherein, the flowing control for limiting conduit fills
At least part put is made of polyurethane or silicones.
Embodiment 22：A kind of side manufactured for reducing or stablizing the equipment of intraocular pressure from ocular drainage aqueous humor
Method, eyes have anterior chamber and include the external ocular of cornea, the corneal limbus surrounded and the eyes under eyelid, surrounded by this
Corneal limbus cornea be continuous with Scleral shell and conjunctiva layer, this method includes making the port of export of pipe fitting and the chamber limited by housing
It is in fluid communication, the port of export extends to the arrival end suitable for being in fluid communication with the anterior chamber of eyes, which is suitable for guiding from anterior chamber
And pass through arrival end and the flow of aqueous humor to the port of export so that aqueous humor is received by chamber；And make distensible flow control apparatus
It is engaged with housing, which is suitable for controlling the flow of aqueous humor of the position outside from chamber to anterior chamber, and limits
Be scheduled on the conduit connected between chamber and external position, the intraocular pressure which may be in response to more than the pressure being pre-selected and expand
, to increase flow or to reduce resistance and so that intraocular drops to the flowing of the aqueous humor by conduit to external position
To no more than the pressure being pre-selected.
Embodiment 23：The method or combination of any aforementioned or aftermentioned embodiment, including filter for installation is arranged as
It is in fluid communication between the arrival end and flow control apparatus of pipe fitting, for filtering the dirt from aqueous humor before flow control apparatus
Contaminate object.
Embodiment 24：The method or combination of any aforementioned or aftermentioned embodiment, including filter for installation and housing is made to exist
It is engaged after the port of export of pipe fitting so that flow control apparatus is removable or interchangeable relative to housing, so as to allow
Filter unit is removed and replaced.
Embodiment 25：The method or combination of any aforementioned or aftermentioned embodiment, including make filter for installation engagement be with
Flow control apparatus is in fluid communication, opposite with the port of export of the pipe fitting from flow control apparatus, is arrived for filtering from any
The pollutant of the reflux of flow control apparatus.
Embodiment 26：The method or combination of any aforementioned or aftermentioned embodiment, including filter for installation is made to be controlled in flowing
It is engaged after device processed with housing so that the filter for installation being engaged with it is removable or interchangeable relative to housing.
Embodiment 27：The method or combination of any aforementioned or aftermentioned embodiment, wherein, make distensible flowing control dress
Put and engaged with housing including distensible flow control apparatus is made to be engaged with housing, wherein, flow control apparatus be limited to chamber with
The multiple conduits connected between external position, and wherein at least one of conduit is distensible.
Embodiment 28：The method or combination of any aforementioned or aftermentioned embodiment, wherein, make distensible flowing control dress
It puts and is engaged with housing including distensible flow control apparatus is made to be engaged with housing, wherein, which limits setting
For multiple conduits that are parallel and being connected between chamber and external position.
Embodiment 29：The method or combination of any aforementioned or aftermentioned embodiment, wherein, make distensible flowing control dress
It puts and is engaged with housing including distensible flow control apparatus is made to be engaged with housing, wherein, conduit includes and is limited by housing
The single ingress port and be respectively in fluid communication with the ingress port by the corresponding channel extended from ingress port that chamber is in fluid communication
Multiple outlet ports.
Embodiment 30：The method of any aforementioned or aftermentioned embodiment or combination, wherein, make distensible flowing control dress
It puts and is engaged with housing including distensible flow control apparatus is made to be engaged with housing, wherein, each channel is from single arrival end bore
To extending outwardly so that outlet port is angularly spaced around ingress port.
Embodiment 31：The method or combination of any aforementioned or aftermentioned embodiment, wherein, flow control apparatus includes first
Part and the second part complementally constructed, first part limit the single arrival end being in fluid communication with the chamber limited by housing
Mouthful, and second part limits multiple outlet ports, and wherein this method includes first part and second part is made to engage to limit
Fixed liquid storage device between them, and each outlet port is connected with ingress port via the reservoir fluid.
Embodiment 32：The method or combination of any aforementioned or aftermentioned embodiment, including making flow control apparatus and laser
The output of device is engaged so as to form additional distensible conduit in flow control apparatus.
Embodiment 33：The method or combination of any aforementioned or aftermentioned embodiment, including making flow control apparatus and laser
The output engagement of device, so as to seal the conduit limited by flow control apparatus.
Embodiment 34：The method or combination of any aforementioned or aftermentioned embodiment, wherein, make distensible flowing control dress
It puts and is engaged with housing including being inserted into distensible flow control apparatus in the chamber limited by housing.
Embodiment 35：A kind of to be used for from ocular drainage aqueous humor for reducing or stablizing the equipment of intraocular pressure, eyes have
Anterior chamber and the external ocular for including cornea, the corneal limbus surrounded and the eyes under eyelid pass through the corneal limbus angle surrounded
Film is continuous with Scleral shell and conjunctiva layer, which is included in the pipe fitting extended between arrival end and the port of export, and arrival end is fitted
It is in fluid communication in the anterior chamber of eyes, and pipe fitting is suitable for guiding from anterior chamber and passes through the aqueous humor of arrival end to the port of export
Stream；Flow control apparatus is operatively engaged with the port of export and constructs the position outside pipe fitting to anterior chamber in order to control
Flow of aqueous humor, the flow control apparatus are limited to the conduit connected between the port of export and external position, which may be in response to pre-
The intraocular pressure more than pressure that first selects and expand, to increase flow or to reduce to the aqueous humor by conduit to external position
The resistance of flowing and so that intraocular pressure drops to no more than the pressure that is pre-selected；First filter device, is arranged as in pipe
It is in fluid communication between the arrival end and flow control apparatus of part, which is configured to before flow control apparatus
Filter the pollutant from aqueous humor；With the second filter for installation, it is arranged as being in fluid communication with flow control apparatus, is flowed with coming from
The port of export of the pipe fitting of control device is opposite, which is configured to filter to any of flow control apparatus
The pollutant of reflux.
Embodiment 36：The method or combination of any aforementioned or aftermentioned embodiment, wherein, first filter device and pipe fitting
Port of export engagement, and wherein, flow control apparatus is operatively engaged with first filter device so that flowing control fills
It is removable or interchangeable to put relative to it, so as to which first filter device be allowed to be removed and replaced.
Embodiment 37：The method or combination of any aforementioned or aftermentioned embodiment, wherein, the second filter for installation and flowing
Control device engages, is opposite with first filter device, and wherein, and flow control apparatus is constructed so that the second filter fills
It is removable or interchangeable to put relative to it, so as to which the second filter for installation be allowed to be removed and replaced.
Embodiment 38：The method or combination of any aforementioned or aftermentioned embodiment, including limiting the port of export stream with pipe fitting
The housing of the chamber of body connection, which is configured to receive aqueous humor, and housing is configured to be operatively engaged flow control apparatus and cause
The flow control apparatus adjusts the flowing of the aqueous humor from chamber.
By reading described in detail below and attached drawing being briefly described below, these and other feature of the disclosure,
Aspect and advantage will be apparent.The disclosure includes illustrating in the present disclosure or described in any one or more claim
Two, three, four, or more feature or element any combinations, no matter whether this feature or element clearly combine
In other ways in the text specific embodiment description or claims described in.Unless in the context of the disclosure clearly
Ground is otherwise provided, and the disclosure is intended to integrally read so that the disclosure it is any can dtex sign or element in terms of it and implement
Example any one of in should be considered as it is expected, be counted as what can be combined.
Description of the drawings
For a more complete understanding of the present invention, it now should refer to the embodiment for being shown in the drawings and being described below.
In attached drawing：
Fig. 1 is the stereogram of the embodiment of the drainage device for reducing intraocular pressure；
Fig. 2 is the exploded perspective view of drainage device as shown in Figure 1；
Fig. 3 is the longitudinal sectional view of drainage device as shown in Figure 1；
Fig. 4 is the stereoscopic schematic diagram for the drainage device as shown in Figure 1 being implanted in eyes；
Fig. 5 is the side view of the drainage device being implanted in eyes as shown in Figure 4；
Fig. 6 A-6C schematically illustrate drainage device according to various embodiments of the present disclosure；
Fig. 7 is the stereogram of the alternate embodiment of the drainage device for reducing intraocular pressure；
Fig. 8 is the exploded perspective view of drainage device as shown in Figure 7；
Fig. 9 is the longitudinal sectional view of drainage device as shown in Figure 7；
Figure 10 is the stereoscopic schematic diagram for the drainage device as shown in Figure 7 being implanted in eyes；
Figure 11 A-11C schematically illustrate flowing one embodiment, perpendicular to the fluid for flowing through it according to the disclosure
Direction, the expanded configuration of conduit that is limited by flow control apparatus associated with drainage device；
Figure 12 A and 12B schematically illustrate flowing one embodiment, being parallel to the fluid for flowing through it according to the disclosure
Direction, the expanded configuration of conduit that is limited by flow control apparatus associated with drainage device；
Figure 13 schematically illustrates the cut away view of the drainage device of one embodiment according to the disclosure；
Figure 14,15A and 15B schematically illustrate the flowing control each embodiment, for drainage device according to the disclosure
The construction of device processed.
Figure 16 A and 16B schematically illustrate the two-piece flow each embodiment, for drainage device according to the disclosure
The construction of control device.
The method that Figure 17 schematically illustrates manufacture drainage device according to the one side of the disclosure；And
Figure 18 schematically illustrates the twinfilter construction of the drainage device of one embodiment according to the disclosure.
Specific embodiment
Hereinafter reference will be made to the drawings is described more fully the disclosure, and some aspects of the disclosure are shown in the drawings but are not
All aspects.In fact, the disclosure can be implemented with many forms and should not be construed as being restricted to be illustrated in text each
Aspect；On the contrary, propose these aspects so that the disclosure will meet applicable law requirement.What identical reference numeral referred to always
It is identical element.
Certain terms used herein should not be construed as the limitation for the scope of the present disclosure only for convenient.Example
Such as, such as " on ", " under ", "left", "right", " level ", " vertical ", " upward " and " downward " vocabulary only describe and show in figure
The construction gone out.In fact, component can be oriented in any direction, and therefore term is interpreted as comprising this variation, unless separately
It indicates.
Fig. 1 schematically illustrates implantable eye drainage device according to the one side of the disclosure, the implantable eye
Drainage device is generally designated as element 30.Drainage device 30 includes tubular body 32 and spout assembly 34.Tubular body 32 includes entrance
End 44 and the longitudinally opposed port of export 42, and be configured to guide fluid between arrival end 44 and the port of export 42.Drainage device
At least part of 30 tubular body 32 is implanted into the anterior chamber of eyes, for from its drain aqueous humor (see, for example, Fig. 4 and
5)。
The tubular body 32 of drainage device 30 is substantial cylindrical and hollow, and holds 42 with nearly (outlet) and far (enter
Mouthful) end 44.Tubular body 42 is limited to the inner cavity 46 extended between proximal end 42 and distal end 44, and the distal end limits and connected with inner cavity 46
At least one opening 48.At least one opening 48 is configured to be arranged on the fluid inlet at the distal end 44 of tubular body 42.
In some aspects, the distal end 44 of tubular body 32 can be chamfer in order to which distal end 44 enters anterior chamber or in the other parts of eyes.
Inner cavity 46 forms at least part of flow path, the flow path allow from the anterior chambers of eyes by aqueous humor drainage to
Position outside anterior chamber.For example, the position of (anterior chamber's) outside can be the external ocular of eyes.In other cases, it is external
Position may include another room in eyes, subconjunctival space, suprachoroidal space or the like.In one aspect, tubular body
32 have be enough to provide in the anterior chamber of eyes and the fornix under eyelid or coecum (conjunctival sac) region (cul-de-sac
Region the length of the fluid communication between), so that when drainage device 30 is implanted in eyes or is attached to eyes, aqueous humor
Can be flowed through from anterior chamber inner cavity 46 and to in the associated tear film of eyes.Purposes thus, the tubular body 32 of drainage device 30 can
With being, for example, at least about minimum length of 3mm, for the fornix to be positioned under eyelid or coecum areas adjacent.On the one hand
In, tubular body 32 can have adult the length between about 4mm and about 9mm.In use, tubular body 32 can be substantially upper
In in conjunctiva in the following, and remote (input) is held and is arranged in anterior chamber's (or back room) of eyes (see, for example, Figure 4 and 5).However, ability
Field technique personnel will be understood that the position being directed into according to aqueous humor drain from anterior chamber, the size of drainage device 30 with
Deployed position can significant changes.
The shape of transverse direction/lateral cross section of tubular body 32 can be other other than being circle as shown in Figs. 1-5
Suitable shape is such as oval, square, trapezoidal, rectangle or any combination of them.No matter shape, by tubular body 32
The variable dimension of the cross section of the inner cavity 46 of restriction is to selectively change the fluid flow characteristics of aqueous humor.For example, it can be used
The size of relatively small cross section is flowed with limiting the fluid of aqueous humor.In one aspect, the cross sectional dimensions of inner cavity 46 can example
Such as about 1.0mm is changed to from about 0.5mm.
One or more barbs 50 may be configured as the distal end 44 of adjacent tubular body 42.Barb 50 can be from the appearance of tubular body 32
The part in face extends to contact with sclera when equipment 30 is implanted into or is engaged with eyes.Barb 50 be adapted to engage with sclera and
Stability is provided until bioconjugation (biointegration) of the tubular body 32 in lower subconjunctival space.Barb 50 can manufacture
Period is formed as a part for the tubular body 32 of drainage device 30 or then can be melted or be attached in an appropriate manner tubulose
Body 32.
With reference to Fig. 3, the head 36 of spout assembly 34 limits inner cavity 52.Nearly (outlet) of head 36 and tubular body 32 hold 42 into
One is attached to nearly (outlet) end so that the inner cavity 46 of chamber 52 and tubular body 32 is in fluid communication to receive aqueous humor from it
Stream.In shown in terms of, head 36 and tubular body 32 can be integrally formed into as individual unit.Alternatively, each component
It can be formed separately with another.Head 36 can be dome-type (or protrusion) with provide from the outer surface along head 36 to
The substantially continuous transitional surface of ocular surface (i.e. crest curve is configured to form the smooth transitions of ocular surface).Such as
Fruit head feeling can preferably endure this construction/shape on head 36 unlike the foreign matter relative to eyelid in eye, then patient.
However, it will be understood to those of skill in the art that the other shapes on head 36 can be it is suitable and be well-suited for user offer
Similar sensory perception.For example, heads 36 with rounded edges, minimally protrude, substantially flat can be equally good
Ground is tolerated.Other suitable design can be determined by those skilled in the art.When suitable, interior (protrusion) surface on head 36
(or the combination of the two) that can be flat or be bent is corresponding with the shape of the outer surface with sclera, drainage device 30
It is located in sclera.
Head 36 may also include integral tab 54, and the integral tab is outside from the axis for extending through drainage device 30
Extension.Alternatively, lug 54 can be piece being attached to head 36, being formed separately.If the piece that lug 54 is formed separately,
Then lug 54 can be made of flexible biocompatible material, such as silicones or polyurethane, and the biocompatible material of the flexibility can
According to along eye motion, easy deformation.As further disclosed herein, lug 54 (is borrowed available for stablizing drainage device 30
Help head 36) relative to the position of eyes, and drainage device 30 can thus be avoided to be squeezed from it relative to the desired locations of eyes
Go out, while ocular stimulation and/or conjunctiva erosion may also be reduced.
In certain aspects, drainage device 30 may include filter 40 and/or flow control apparatus 39 for maintain and/
Or control intraocular pressure and for allow the more physiological dynamic of aqueous humor.In this aspect, the head 36 of spout assembly 34 can
It is configured to receive flow control apparatus 39 or opening for receiving flow control apparatus 39 can be limited in other ways, filter
40 can be inserted into head 36 by the opening and/or be removed from head 36.
Fig. 2 and 3 is schematically illustrated at the proximal end 42 for the tubular body 32 for being for example, at least partially positioned in drainage device 30
Filter 40 in head 36 and inner cavity 46.In one aspect, filter 40 can be configured with remote become a mandarin and hold 44 and closely go out to flow
The slender member at end 42.As shown in figure 3, for example, filter 40 can be configured to extend laterally across inner cavity 46 so that tubular body 32
The logical route filter 40 of inner cavity close or substantially closed.Therefore, the aqueous humor for flowing through inner cavity 46 is conducted through filter
40, wherein, filter 40 is to filters aqueous to avoid edge along the bacterial migration of the either direction of inner cavity.Filter 40 also may be used
It is configured to by being supplied to the room from the anterior chamber of eyes to external position (that is, to the tear film near the outer surface of eyes in)
Water goes out to flow scheduled resistance to adjust or at least promote the adjusting to intraocular pressure.In certain aspects, filter 40 can construct
For the resistant component of flowing to aqueous humor.That is, filter can be by selecting the hole of such as predetermined quantity and size and selecting
The filter characteristic of total length of filter 40 (i.e. flow path) provide the aqueous humor specific flow rate.These parameters separate
Ground or the suitable resistance of flowing that can be configured to be supplied to aqueous humor in combination, the resistance are enough to reduce and maintain intraocular pressure, simultaneously
Avoid Ocular hypotension.Filter 40 can have the gradient of the pore-size of the length along filter 40.For example, pore-size can be from
The distal end 40 of filter 40 constantly reduces to proximal end 42, so as to avoid the clast product at remote (entrance) end 44 of filter 40
It is poly-.The pore-size of bigger at the distal end of filter 40 44 and at proximal end 42 can provide porosity gradient, and porosity gradient can have
Help reduce the influence blocked to going out flow resistance power.
In certain aspects, filter 40 can be removable and interchangeable, and can be by arriving spout assembly 34
External path promotes, without upsetting position (i.e. tubular body 32) of the drainage device 30 in eyes.By replacing filter 40,
For example, eye pressure can be adjusted by selecting to provide the filter structure (configuration) of selected aqueous humor flow rate.Alternatively, mistake
Filter 40 can be configured to form the permanent element of drainage device 30.
In certain aspects, flow control apparatus 39 can by be in fluid communication with head 36 or in other ways with head 36
It is operatively engaged to be received (that is, the housing for being limited and being provided by head 36).If filter 40 is in this aspect
Implantation, then filter 40 may be disposed so that fluid connects between (remote) end 44 of entrance of tubular body 32 and flow control apparatus 39
It is logical, and filter 40 is configured to filter the pollutant from aqueous humor before flow control apparatus 39.In other cases, it filters
Device 40 can engage, and wherein head 36 after (near) end 42 in the outlet of tubular body (or " pipe fitting ") 30 with the housing on head 36
Housing be constructed so that the flow control apparatus being operatively engaged with it 39 relative to housing be can be removed or alternatively,
So as to which filter 40 be allowed to be removed and replaced.In other aspect, filter 40 may be disposed so that and flow control apparatus
39 are in fluid communication, opposite with (near) end 42 in the outlet of the tubular body 32 from flow control apparatus 39, wherein, filter 40 constructs
To filter the pollutant from any reflux to flow control apparatus 39.In this case, filter 40 can be controlled in flowing
It is engaged after device 39 processed with the housing on head 36, and wherein the housing may be configured so that 40 phase of filter being engaged with it
It is removable or interchangeable for housing.
In some cases, head/housing 36 can be configured to limit chamber 52 therein, and wherein flow control apparatus 39 can structure
Make the flow of aqueous humor of the external ocular from chamber 52 to eyes in order to control.In some specific cases, flow control apparatus 39 is limited to
The conduit 38 connected between chamber 52 and external ocular.In some cases, flow control apparatus 39 may include relatively thin and flexible
Diaphragm (membrane), the diaphragm limit elongate slit form conduit 38 (see, for example, Fig. 1 and 2), wherein, it is flexible every
Film is configured to, in response to raised intraocular pressure and along the length of the slit around middle section deformation, aqueous humor to be allowed to leave draw
Flow device 30.In the other aspects such as shown in Fig. 6 A, Figure 14, Figure 15 A and Figure 15 B, flow control apparatus 39
It may include elongated or relatively thick part, which limits the conduit 38 for extending through thickness.In particular situations, conduit 38
The intraocular pressure that may be in response to more than the pressure or threshold pressure being pre-selected and expand, to increase flow or reduce to by leading
Pipe 38 to the flowing of the aqueous humor of external position (i.e. external ocular) resistance and be not more than with reducing and/or stablizing intraocular and be pressed onto
The pressure being pre-selected.For example, the construction of distensible conduit 38 can be determined according to predetermined intraocular pressure, wherein, it is selected
The eye pressure selected can be for example patient age, physical trait, the feature of eyes, being in progress of the state of an illness, specific physiology dynamic or
It is the factor of specific analog to particular patient.The lateral cross section of conduit 38 can take different forms, such as such as round
It is shape, avette, square, rectangle or any other suitable shape, either rule or irregular.
In certain aspects, as shown in Figure 6B, flow control apparatus 39 may be arranged at the chamber limited by the housing on head 36
In 52.In this case, housing can limit the hole opposite with the flow control apparatus 39 of the port of export 42 from tubular body 32
80, and hole 80 is in fluid communication aqueous humor is allowed to flow out to external position by flow control apparatus 39 and hole 80 with chamber 52.Root
According to the disclosure in text, as shown in Figure 6 C, filter 40 may be arranged at after flow control apparatus 39 (i.e. downstream), with from
(near) end 42 in outlet of the tubular body 32 of flow control apparatus 39 is opposite.For example, filter 40 can with hole 80 going out on head 36
It is engaged near mouthful.In this aspect, filter 40 can be configured to filter from any reflux to flow control apparatus 39
Pollutant, external contaminants to be prevented to reach flow control apparatus 39 or is constructed so that filter 40 and flow control apparatus
39 associateds are to resist or prevent in bacterial invasion to the tubular body 32 for the inside for leading to eyes.
In one aspect, the part of at least restriction conduit 38 of flow control apparatus 39 can be configured in response to being selected in advance
The intraocular pressure more than pressure selected and expand (see, for example, attached drawing 11A-11C and 12A-12B).The cross-sectional area of conduit 38
This expansion and expansion in (region) allow for flowing or the increase of flow or the aqueous humor to arriving external position by conduit 38
Flowing resistance reduction, thus reduce and/or stablize intraocular being pressed onto less than or equal to the pressure that is pre-selected.That is, at least
The part of the restriction conduit 38 of flow control apparatus 39 can be configured with the expansion feature of pressure response.In other cases,
The part of at least restriction conduit 38 of flow control apparatus 39 can be configured with the actuator (not shown) being engaged with it, wherein
Actuator is configured to cause the expansion of the part of the restriction conduit 38 of at least flow control apparatus 39.In certain aspects, at least
The part of the restriction conduit 38 of flow control apparatus 39 may be configured so that conduit 38 usually narrow with prevent flow of aqueous humor through it (i.e.
Conduit 38 is normally closed).Once being expanded in response to the intraocular pressure for being more than previously selected pressure, then conduit 38 also can structure
It makes to be contractile or being configured to shrink, the aqueous humor generation in response to reduction causes intraocular pressure to drop to the pressure being pre-selected
Hereinafter, with reduce or make flowing stop or with increase to by conduit 38 to external position aqueous humor flowing resistance, and
Thus intraocular pressure is allowed to be increased to no more than the pressure being pre-selected.The pressure of the part of the restriction conduit 38 of flow control apparatus
Therefore the expansion feature of force-responsive can be operable, (to depend on Mr. Yu day regardless of the aqueous humor dynamic characteristic of specific patient
Or the time in one day individual aqueous humor generate rate) and adjust flow of aqueous humor and therefore not only make intraocular pressure fall to in advance
The pressure first selected is consistent, and promotes the stabilization to intraocular pressure.
In certain aspects, flow control apparatus 39 can be configured to be limited to connected between chamber 52 and external position it is multiple
Conduit 38 (see, for example, Figure 15 A and 15B).In this case, at least one in conduit 38 is that for example may be in response to be more than pre-
The intraocular pressure of the pressure first selected and expand or by suitable actuator (not shown) activate expand when expand.Multiple conduits 38
It may be configured as parallel and connected between chamber 52 and external position.As shown in Figure 16 A, conduit 38 may include for example single entrance
Port 200 and multiple outlet ports 220, which is in fluid communication with the chamber 52 limited by housing, and each exports
Port from the corresponding channel 219 that ingress port 200 extends and ingress port 200 by being in fluid communication.In another construction, such as
Shown in Figure 16 B, each channel 210 can be configured to extend radially outwardly from single ingress port 200 so that outlet port 220 surrounds
Ingress port 200 is angularly spaced.
In another aspect, as shown in figure 13, flow control apparatus 39 may include first part 230 and second part 240,
The single ingress port 200 that the restriction of first part 230 is in fluid communication with the chamber 52 limited by the housing on head 36, and second part
240 limit multiple outlet ports 220.In such one side, first part and second part 230,240 are configured to complementally connect
It closes, so as to limit liquid storage device 250 between them, wherein, each outlet port 220 is via the liquid storage device 250 and arrival end
Mouth 200 is in fluid communication.Since second part 240 limits outlet port 220, and it can therefore guide and be directed toward outside head 36, the
Two parts 240 can be configured to relative stiffness, so as to resist the deformation of the power in response to being applied to it.Under specific circumstances,
A part and second part 230,240 can be configured to for example in response to the output of laser aid (not shown), thus by each component
It is attached together.
In every aspect disclosed in the text, the housing on head 36 may be configured so that the stream being operatively engaged with it
Dynamic control device 39 is removable or interchangeable relative to housing.That is, flow control apparatus 39 can be can relative to housing
Remove/alternatively, no matter it is arranged in chamber 52 or the hole 80 with being limited by housing engages.In addition, flow control apparatus 39
Can be relative to housing removable/replaceable, no matter filter 40 whether be arranged in flow control apparatus 39 after/under
Trip.Additionally, flow control apparatus 39 can be relative to housing removable/replaceable, so as to be arranged in flowing control dress
(being engaged with the port of export of the tubular body 32 42) filter 40 for putting 39 upstreams also can be removable/replaceable.
For example, as shown in Fig. 7-Figure 10 and generally by 100 marks, drainage device 100 may include tubular body 102 and go out
Mouth component 104, wherein, spout assembly 104 includes limiting the head 106 of opening 108, which is configured to be inserted into filter
110 neutralize to head 106 from the removal of head 106 filter 110.Can be removed with the flow control apparatus 150 being engaged with it
Circular cap component 109 be provided for sealed opening 108 and for (such as slit 112 being shown as, although herein via conduit
Disclosed in the construction of any flow control apparatus with distensible conduit it is applicable) into the inside on head 106.Drainage
At least part of the tubular body 102 of equipment 100 is implanted into the anterior chamber of eyes, for from its drain aqueous humor.Drainage is set
Standby 100 tubular body 102 can be substantially oval-shaped and limit inner cavity 114, the inner cavity 114 is in the proximal end of tubular body 102 116
Extend between distal end 118.The distal end 118 of tubular body 102, which is limited, connects and is used as at least the one of fluid inlet with inner cavity 114
A opening 120.The protruding portion 122 or barb of one or more tapers may be configured as the distal end 118 of adjacent tubular body 102.Outlet
The head 106 of component 104 may also include the outwardly extending integrated radial direction lug 124 of longitudinal axis from drainage device 100.Figure
9 show, head 106 can limit the inner chamber 126 being in fluid communication with the inner cavity of tubular body 102 114, wherein, inner chamber 126 constructs
To accommodate and receiving filter 110.Round edge 128 is used to limit opening 120 radially outward from the surface on head 106.Filtering
Device 110 is arranged in head 106, and be constructed so that the lumen passageway of tubular body 102 outlet be close or substantially
It is closing or being occupied in other ways by filter 110.Filter 110 is configured to that the bacterium of the inside towards eyes is prevented to move
It moves, and can be configured to by providing scheduled resistance from the anterior chamber of eyes towards the stream that goes out of the aqueous humor of external position (i.e. tear film)
Power adjusts intraocular pressure or promotes adjusting to intraocular pressure.Flow control apparatus 150 in cap 109 can be constructed to allow for
It flow to external position (i.e. on sclera and into tear film), while offer pair outwardly by the stream that goes out of the aqueous humor of filter 110
The resistance and the limitation to reflux or bacterial invasion that aqueous humor goes out stream.
The part of flow control apparatus 39 or at least its restriction conduit 38 can be by such as polyurethane or silicones
Flexible biocompatible material is formed.In some cases, the material of flow control apparatus 39 or composition flow control apparatus 39
Can be configured to for example in response to the output of laser aid (not shown), so as to formed or opened distensible channel wherein or
Component is attached together.That is, the laser output being directed toward at the material for including flow control apparatus 39 can cause additional conduit
38 form or open, as needed or desired for controlling the flowing of the aqueous humor from eyes and thus control intraocular pressure.
Under concrete condition, the material of flow control apparatus 39 or composition flow control apparatus 39 is also configured to for example fill in response to laser
The output put is to seal or shrink the conduit thus limited 38.That is, one or more of conduit 38 can as needed or it is expected
Sealed or shunk, the resistance of the flowing to the aqueous humor from eyes is flowed or manipulated with control.In specific aspect, to by
Laser modified (the laser modification) of the conduit that flow control apparatus 39 limits or form flow control apparatus 39
Material can (in body), (in situ) be realized in situ, and drainage device 30 is in place relative to eyes.In addition to it is to laser aid
Except the response of output or substitute the response, flow control apparatus 39 can by any suitable miniature product manufacturing technology or
Technique is made.For example, executable photoetching process/deposition technique, casting, molding or any other suitable technology or combination with
In formation flow control apparatus 39.
As shown in figure 11, flow control apparatus 39 or (one or more) conduit at least associated with it, (one or more
It is a) channel and (one or more) port can be configured to open (expansion) and closing (contraction) to adjust and/or stablize from head
The aqueous humor of 36 inner chamber 52 to external position flows and (flow on sclera and enter tear film) also, by doing so will
Intraocular pressure is maintained in the range of about 7mmHg to about 20mmHg.For example, when intraocular pressure is more than the pressure being pre-selected, conduit 38
It will expand or activated to expand and allow aqueous humor to leave spout assembly 34 (that is, by reducing or reducing the stream to aqueous humor
Dynamic resistance).When intraocular pressure is reduced to predetermined pressure hereinafter, since aqueous humor is by the flowing of spout assembly 34 and from going out
The flowing of mouth component 34, conduit 38 will shrink to its normal condition (closing or partially opening) and limit or inhibit aqueous humor
Leave head 36 (that is, the resistance of increase to the flowing of aqueous humor).Conduit 38 will keep (closing in its normal condition or part being beaten
Open) until intraocular pressure arrives again at or more than the pressure being pre-selected, the moment conduit 38 will further expansion to allow or add
Strong further drainage or the resistance reduced to the flowing of aqueous humor.In certain aspects, flow control apparatus 39 limits conduit 38
Part can be configured to along the flow direction of aqueous humor or perpendicular to the flow direction of aqueous humor expand.Those skilled in the art will
Understand, the overall dimensions of the drainage device 30 due to being used for application scenario disclosed in text, with flow control apparatus 39
Associated (one or more) conduit, (one or more) channel and (one or more) port with micron dimension or nanometer
The relative size of magnitude is formed, and therefore correspondingly selects manufacturing technology and technique performed in its production.
Therefore, drainage device 30 is provided based on intraocular pressure through drainage of the drainage device 30 to the anterior chamber of eyes, and is subtracted
The small possibility that drainage is crossed to anterior chamber and leads to hypotony.Additionally, there is essentially unidirectional (anti-backflow) valve system
Flow control apparatus 39 prevent the reflux of aqueous humor.Therefore those skilled in the art will be appreciated that, pressure actuated check-valves
Any suitable type or do not know consistently be carried out with application parameter disclosed herein.
Other than the material described, at least tubular body and spout assembly of each embodiment of drainage device 30,100 can
By with good biocompatibility and durability and be that sufficiently flexible material is formed.Suitable material is included from including silicon
Resin, acrylic acid, polyimides, polypropylene, polymethyl methacrylate, polytetrafluoroethylene (PTFE), hydrogel, polyolefin, polyolefin
Resin such as polyethylene, polyisobutene, vinyl-vinyl acetate copolymer, polynorbornene, polyvinyl chloride, polyester, polyethylene
Alcohol, polyvinylpyrrolidone, polyether sulfone (PES), poly- (styrene-isobutyl group-styrene), polysilicon, polyurethane, makrolon
Polyurethane, glass and ceramic such as aluminium oxide and titanium dioxide, metal such as stainless steel, titanium, gold, silver, platinum, Nitinol, collagen
Or chemically treated collagen, hydroxyapatite, nature and synthetic rubber such as polybutadiene, polyisoprene, SBR (butylbenzene rubbers
Glue) and SIR, polyacetal resin, ABS (acrylonitrile-butadiene-styrene copolymer) resin, solid HEMA polymer and its
Combination.
At least part of (one or more) filter 40 have be small enough to prevent such as bacterium, virus, fungi and
The microorganism of spore enters or flows back into the pore-size of inner cavity 46, so as to minimize the possibility that reflux is interfered in eye.It is small
Being small enough in about 0.4 μm of pore-size prevents microorganism from entering or flowing back.In certain embodiments, filter 40 may include
More micron openings/materials of the microcapsules of the diaphragm of Donna metre hole or polymer network, network of fibers or network with hole.It is suitable
Including micro porous filtration diaphragm together in the micro porous filtration diaphragm being used together with Ophthalmoligic instrument, (makrolon, gathers inclined difluoro at polyether sulfone
Ethylene, polytetrafluoroethylene (PTFE)), porous aquagel (polyacrylamide, alginates, poly hydroxy ethyl acrylate) and micropunch silicon tree
The polyethylene polymer of fat or such as polyvinyl alcohol can expand in inner cavity 46.Other suitable polymer include polyolefin
Polymer, ethylene-vinyl alcohol copolymer, polyacrylonitrile polymer, cellulosic polymer, cellulose acetate polymer and polyamide
Polymer.Filtering diaphragm nanometer technology by microporous diaphragm for being made for bio-compatible, non-degradable and being immunized
Isolation also can be useful.The metal of such as ceramic other materials, polymer and such as titanium is also suitable for filter.It should
Photoetching or electrostatic can be used to generate for filter.In some cases, filter 40,110 can have antibiotic coating with for
It avoids polluting during changing.It describes to filter in co-pending No. 2010/0057055 kind of the U.S. Patent Application Publication No. looked into
The suitable coating of device, content full text in a manner of to be included in herein.
At least part of the outer surface of the ontology of drainage device 30,100, lug and/or the inner surface on head can apply
Be covered with porous, fiber cell to interior growth coating.The ingrown coating of porous cell, which is at least coated in, to be drawn
On the part contacted when being implanted into drainage device with sclera and conjunctiva of flow device 30,100.The ingrowing of the porous cell
Coating can be hydroxyapatite or porous polyethylene, be used to being promoted cell adhesion.Selected growth factor can be inhaled
Receive so that drainage device 30,100 ontology and lug can securely rivet it is in place.This enables drainage device 30,100 in original
Ground resistance action and displacement.Adhere in order to further enhance tissue ingrowth (tissue is grown into) and cell, drainage device 30,
100 ontology may include such as texture, hardening or the surface modification of other irregular shapes for having pattern or a pattern-free.
The remaining surface of drainage device 30,100, including entire surface of internal cavity, drainage device outer surface not with sclera
The part of contact, and/or filter surfaces can be coated with the face coat of biologically inert (bio-inert) to strengthen surface biological
Compatibility.This coating may include biologically inert polymer, such as Phosphorylcholine (PC), polyethylene glycol (PEG), sulfobetaines
(SB), carboxybetaine (CB) and polyethylene oxide (PEO).These polymer coatings when being transplanted on surface mainly by inhaling
Draw big and stable hydration housing to lower harmful biological respinse.Biologically inert face coat can by such as heparin, spermine,
Surfactant, the bioactive molecule of protease or other enzymes or other revisable bio-compatible chemicals and it is further
Modification is fixed with surface.PEO is also suitable for for the end group connector to bioactive molecule surface cure.Add this biology
The molecule of activity can advantageously assign specific, desired function, such as the hydrophily on surface is allowed to further increase.
Coating for drainage device 30,100 may also comprise material, which includes therapeutic agent and antifibrotic agents
And/or antiseptic and/or anti-fouling agent.Therapeutic agent may be selected from including heparin, selenium, conversion the development factor (TGF-beta), intraocular pressure
Reduce the group of drug and antiproliferative.Coating can be for example drug-eluting layer, anti-formation thrombus coating and/or lubricant coating.It can
Include poly (parlene C), poly- (butyl methacrylate), poly- (first for the material of drug eluting coatings
Base methyl acrylate), polyethylene -co- vinyl acetate and other materials known in the art.Antimicrobial coating may include for example
Selenium, silver, melamine or Fano Lay obtain (fimbrolide) or other quorum sensing inhibitor.In addition, these agent can be via altogether
Valence link, metalwork, ionic bond or non-covalent bond or covered by adsorption in the filtering material of drainage device 30,100 or
In other components.
Another aspect disclosed herein is related to manufacture for reducing and/or stablizing intraocular pressure from ocular drainage aqueous humor
Equipment method, as shown in such as Figure 17.This method includes the chamber that the port of export of pipe fitting is made to be joined to and be limited by housing
In fluid communication, wherein, the port of export extends to the arrival end suitable for being in fluid communication with the anterior chamber of eyes, and wherein the pipe fitting is fitted
From anterior chamber and pass through arrival end and the flow of aqueous humor to the port of export in guiding so that aqueous humor is received (block 300) by chamber.Such as block
Shown in 320, distensible flow control apparatus is engaged with housing, wherein, distensible flow control apparatus is suitable for control aqueous humor
The flowing of position outside from chamber to anterior chamber, and wherein distensible flow control apparatus is also defined in chamber and external position
Between the conduit that connects.Intraocular pressure that-the conduit may be in response to more than the pressure being pre-selected and expand, to increase flow
Or with reduction is to the resistance by conduit to the flowing of the aqueous humor of external position and so that intraocular pressure is reduced to no more than advance
The pressure of selection.This manufacturing method can be come real with reference to (one or more) drainage device as disclosed herein and its component
It is existing.
Relative to this manufacturing method, it is between the arrival end and flow control apparatus of pipe fitting that can make filter unit engagement
It is in fluid communication, for filtering the pollutant from aqueous humor before the flow control apparatus.In some cases, filter fills
Putting can engage after the port of export of pipe fitting with housing so that flow control apparatus is removable or replaceable relative to housing
, so as to which filter for installation be allowed to be removed and replaced.In another aspect, it is to enter flowing control that filter for installation is engageable
Device is in fluid communication, is opposite with the port of export of the pipe fitting from flow control apparatus, is come from for filtering to flowing control dress
The pollutant of any reflux put, and in some cases, filter for installation can be followed by with housing in flow control apparatus
It closes so that the filter for installation being engaged with it is removable or interchangeable relative to housing.It is expansible in also one side
Flow control apparatus can be plugged into the chamber limited by housing.As disclosed in text about the various aspects of flow control apparatus
, the part of at least flow control apparatus restriction (one or more) conduit can be by the material structure of the output in response to laser aid
Into.Then, the various aspects of this method may include flow control apparatus is made to engage with the output of laser aid, so as to form flowing control
Additional distensible conduit or so as to seal the conduit limited by flow control apparatus in device processed.
All aspects of drainage device 30,100 disclosed in text can perform the operation implantation under local anesthesia, may be in conjunctiva
Lower supplement.In general, customary surgical procedures can be used to be inserted into sclera for drainage device 30,100.
As shown, such as one side of the Figure 4 and 5 about drainage device 30, for being implanted into the process packet of drainage device 30
Include the initial step of the about 4mm from limbal incision or puncture conjunctiva to fascia space (Tenon ' s space) in fornix space
Suddenly.The distal end 44 of pipe fitting 32 then passes through the notch in fornix so that tubular body 32 passes through under conjunctiva, and spout assembly 34
Outside on the conjunctiva in the coecum region below eyelid.Then, conjunctiva is incised to downwards cornea from fornix notch
Edge is so that the sclera in lower section exposes, for the insertion of the distal end 44 of pipe fitting 32.It can in the position of the sclera exposed now
Using any one of instruments numerous known to needle, trochar, scalpel or oculist to cause to enter across sclera
Stab notch in anterior chamber.Then the tip of the distal end 44 of tubular body 32 is inserted through to the sclera road (beam) (tract) of notch
And it is inserted into anterior chamber or the back room of eyes.The rest part of tubular body 32 remains positioned in the outside of the ocular of eyes.It can
Selection of land, tubular body 32 can be sewn onto sclera.
Then, it is made in two parallel notch to the conjunctiva adjacent with spout assembly, separates about 2mm to 4mm.By lug
54 are inserted into each notch.Each lug 54 can be sewn onto sclera with 10-0 nylon sutures.Then it is surrounded using suture with being closed
The conjunctiva of lug 54, and the middle section for leaving spout assembly 34 is exposed.In certain embodiments, hole can be equipped in lug to use
In to the additional suture in sclera, 30 further stability of drainage device is supplied to until bioconjugation is completed.Similarly,
Include the aspect of suture stick (suture bars) for drainage device, suture stick is sewn onto in sclera for fixed equipment
Ontology.Then, it repairs conjunctiva and makes to make cut closure with suture or the upper acceptable adhesive of biology by known method.It is right
In the drainage device 100 with lip or edge or conduit, purse wire (pures-string) 8-0 sutures can be used to surround
Outlet closes tightly conjunctiva.
In use, aqueous humor flows into drainage device 30 from the anterior chamber of eyes or back room and passes through tubular body 32 via inner cavity
With pass through filter 40, and discharged via the flow control apparatus 39 in spout assembly 34.As disclosed in, pass through drainage device 30
Flow path can be configured to adjust aqueous humor drainage for scheduled speed (that is, such as by the passable size of flow control apparatus
Adjusted), so as to be arrived intraocular pressure-regulated in pressure (i.e. threshold value) predetermined or being pre-selected or predetermined or advance select
The pressure selected is hereinafter, and be further used for the reflux to antimicrobial invasion or to eyes.Aqueous humor goes out stream by filter
It 40 and flow control apparatus 39 or constant alone or in combination adjusts in the pressure that is pre-selected, so as to draw for appropriate
Stream calculation it is predictable go out flow velocity rate or pressure response, for intraocular pressure to be maintained to the pressure being pre-selected, generally about
Between 6mmHg to about 18mmHg, and specifically between about 8mmHg and about 12mmHg.Flow velocity will be based on aqueous humor and generate
Variation avoids low pressure simultaneously, and aqueous humor is generated usually between about 1 μ L/min and about 4 μ L/min, and low pressure can be sent out when less than 5mmHg
It is raw.
The another aspect (see, for example, Figure 18) of disclosure in text, may also provide for from ocular drainage aqueous humor
For reducing and/or stablizing the equipment of intraocular pressure, wherein, this equipment 30, which is included between arrival end and the port of export 42, to be extended
Pipe fitting 32, the wherein port of export is suitable for being in fluid communication with the anterior chambers of eyes, and wherein pipe fitting 32 is suitable for guiding from anterior chamber simultaneously
And pass through arrival end to the flowing of the aqueous humor of the port of export 42.Flow control apparatus 39 is operatively engaged with the port of export 42, and
Construction in order to control from pipe fitting 32 to anterior chamber outside position aqueous humor flowing, wherein, flow control apparatus 39 is limited to outlet
The conduit 38 connected between end 42 and external position, and wherein conduit 38 may be in response to the eye more than the pressure being pre-selected
Internal pressure and expand, with increase flow or reduce to by conduit 38 to external position aqueous humor flow resistance and so that intraocular pressure drop
As low as no more than the pressure being pre-selected.In this aspect, first filter device 85 be arranged in the arrival end of pipe fitting with
It is in fluid communication between flow control apparatus 39, wherein, first filter device is configured to filter before flow control apparatus 39
Pollutant from aqueous humor, and the second filter for installation 90 is arranged as being in fluid communication with flow control apparatus 39, be flowed with coming from
The port of export 42 of the pipe fitting 32 of control device 39 is opposite, wherein, the second filter for installation 90 is configured to filtering from any to stream
The pollutant of the reflux of dynamic control device 39.
In some cases, first filter device 85 is engaged with the port of export 42 of pipe fitting 32, and is filled with flowing control
It puts 39 to be operatively engaged so that flow control apparatus 39 is removable or replaceable relative to it, so as to allow first filter
Device 85 is removed and replaced.Second filter for installation 90 can be engaged with flow control apparatus 39, be filled with the first filter
Put 85 relatively, wherein, flow control apparatus 39 is constructed so that the second filter for installation 90 is removable relative to it or can replace
It changes, so as to which the second filter for installation 90 be allowed to be removed and replaced.The method or combination of any aforementioned or aftermentioned embodiment,
Housing including limiting the chamber being in fluid communication with the port of export of pipe fitting, which is configured to receive aqueous humor, and housing is configured to grasp
Making ground engagement flow control apparatus causes the flow control apparatus to reconcile the flowing of the aqueous humor from chamber." twinfilter " construction packet
The component of other disclosed (one or more) drainage device containing such as this paper, particularly wherein filter 85,90 is arranged in flowing
39 upstream and downstream of control device.Therefore, twinfilter construction for example for drainage device provide filtering to aqueous humor and
Prevent the reflux of pollutant, and eliminate in itself from flow control apparatus 39 be related to choking resistance or contaminant transportation will
It asks.In certain aspects, each and flow control apparatus 39 in 85 and second filter 90 of first filter can be configured to
Individually it can remove or replace.However, the different combinations of first filter and the second filter and flow control apparatus can
It is configured to can be removed or interchangeable, including all three components as individual unit.
Twinfilter construction with the flow control apparatus being arranged between them can provide control and/or stablize eyes
In pressure physiology design.The sclera of lower pressure limit being pre-selected that flow control apparatus is implanted as providing intraocular pressure is quiet
Pulse pressure power apparatus.Each filter can provide resistance in a manner of the trabecular network in human eye.Therefore combination can be produced based on aqueous humor
Raw day-night change and eye pulse and provide the natural pressure change in eyes.Therefore, text described in drainage device 30,
100 various aspects provide out stream feature, this goes out to flow feature and imitates and illustrate that the possibility in the eyes of health varies with each individual
Aqueous humor dynamic.The various aspects of drainage device 30,100 disclosed in text may include any in previously disclosed material
Kind.Drainage device 30,100 can be by traditional micro-processing technology or by being commonly used to manufacture optical fiber or semiconductor or other micro-
The process of rice magnitude or nanometer scale system is made.For example, in certain is embodiment, drainage device 30,100 can be painted with extension
Through its hole or inner cavity.It in certain embodiments, can be by cutting off tubular body in the cone point of the far-end of ontology
End constructs.This can generate conical section, the conical section can be used for during implantation pierce through or cut ocular tissue and
Acanthopore or notch is made to be expanded during drainage device 30,100 advances.It can implement other methods of manufacture drainage device 30, such as originally
Field technology personnel will be understood that.
Every aspect of drainage device 30,100 proposes the method for treating glaucoma, wherein aqueous humor is allowed to pass through operation
Implantation flows out anterior chamber or the back room of eyes to the access of anterior chamber or the position of the outside of back room.Drainage device 30,100 is implanted into
When it is to the invasive minimum of ocular tissue and minimum for the people's foreign body sensation for being implanted into equipment.Make the outlet of drainage device 30,100
Component fixation is important feature.By using biocompatible material and by set drainage device 30,100 each section have with
Fixation is strengthened on porous, cell, the ingrown surface of eye tissue contact, to promote tissue integral with sclera.
With polymer or bioactive molecule, to the surface coating of drainage device 30,100 or in polymer, offer activating agent also promotes
Surface biocompatible or fixation or rear implantation.All these features help to minimize caused by eye motion (micromotion)
The problem of, including the displacement to the intrusion sense of ocular tissue, pain and drainage device 30,100.Elimination micromotion can also avoid all
Such as the adverse events of fibrosis, erosion, exposure and/or extrusion.
In addition, the embodiment of drainage device 30,100 as disclosed herein can be used for treating its other than glaucoma
Its eye disease.In an example kind, drainage device 39,100 can be used for treating xerophthalmia, wherein, leave the room of drainage device
Water combines the lubrication for enhancing humidity and eyes kind with tear film.
Many modifications of the disclosure and other aspects will be expected having preceding by disclosure those skilled in the art
The benefit of teachings presented in the description in face and associated attached drawing.It is to be understood, therefore, that the present disclosure is not limited at this
Specific features disclosed in text, and change and be intended to be included within the scope of the appended claims with other aspects.Although
Specific term is used in the text, but they are used rather than for purposes of limitation with general and describing significance.
Claims (38)
1. a kind of be used for from ocular drainage aqueous humor for reducing or stablizing the equipment of intraocular pressure, eyes have anterior chamber and including
Cornea, around corneal limbus and the eyes under eyelid external ocular, by the corneal limbus around described, the cornea and
Scleral shell and conjunctiva layer are continuous, and the equipment includes：
Pipe fitting, the pipe fitting extend between arrival end and the port of export, and the arrival end is suitable for anterior chamber's fluid with eyes
Connection, and the pipe fitting is suitable for guiding from the anterior chamber and the stream by aqueous humor of the arrival end to the port of export
It is dynamic；
Housing, the housing limit the chamber being in fluid communication with the port of export of the pipe fitting, and the chamber is configured to receive aqueous humor；
And
Flow control apparatus, the flow control apparatus are operatively engaged with the housing, and construct in order to control aqueous humor from
To the flowing of the position of the outside of the anterior chamber, the flow control apparatus is limited between the chamber and external position the chamber
The conduit of connection, the conduit can be expanded in response to the intraocular pressure more than the pressure being pre-selected, to increase flow or subtract
The resistance of the small flowing to by aqueous humor of the conduit to the external position and so that the intraocular pressure drops to less
In the pressure being pre-selected.
2. equipment as described in claim 1, which is characterized in that including filter for installation, the filter for installation is arranged as
It is in fluid communication between the arrival end and the flow control apparatus of the pipe fitting, the filter for installation is configured to described
The pollutant from aqueous humor is filtered before flow control apparatus.
3. equipment as claimed in claim 2, which is characterized in that the filter for installation and the housing are in the institute of the pipe fitting
It states the port of export to engage later, and wherein, the housing, which is constructed so as to control with the flowing that it is operatively engaged, to be filled
It is that can remove or can replace to put relative to the housing, so as to which the filter for installation be allowed to be removed and replaced.
4. equipment as described in claim 1, which is characterized in that including filter for installation, the filter for installation be arranged as with
The flow control apparatus is in fluid communication, institute opposite with the port of export of the pipe fitting from the flow control apparatus
Filter for installation is stated to be configured to filter the pollutant from any reflux to the flow control apparatus.
5. equipment as claimed in claim 4, which is characterized in that the filter for installation after the flow control apparatus with
The housing engagement, and wherein, the filter for installation that the housing is constructed so as to be engaged with it is relative to the shell
Body is to remove or can replace.
6. equipment as described in claim 1, which is characterized in that the flow control apparatus is limited to the chamber and the outside
The multiple conduits connected between position, and wherein, at least one of described conduit is expansible.
7. equipment as claimed in claim 6, which is characterized in that the conduit be provided parallel to and the chamber with it is described outer
Portion connects between position.
8. equipment as described in claim 1, which is characterized in that the conduit includes the chamber stream with being limited by the housing
The single ingress port of body connection and multiple outlet ports, each outlet port pass through pair that extends from the ingress port
The channel answered is in fluid communication with the ingress port.
9. equipment as claimed in claim 8, which is characterized in that the channel prolongs radially outwardly from the single ingress port
It stretches so that the outlet port is angularly spaced around the ingress port.
10. equipment as described in claim 1, which is characterized in that the flow control apparatus includes first part and second
Point, the single ingress port that the first part limits and is in fluid communication by the chamber that the housing limits, and the second part
Multiple outlet ports are limited, the first part and the second part are configured to complementally engage to limit between them
Liquid storage device, and each outlet port is in fluid communication via the liquid storage device and the ingress port.
11. equipment as claimed in claim 10, which is characterized in that the second part be it is rigid, so as to resist in response to
It is applied to the deformation of its power.
12. equipment as described in claim 1, wherein, the flow control apparatus is configured to the output in response to laser aid
So as to form additional, distensible conduit therein.
13. equipment as described in claim 1, which is characterized in that the flow control apparatus is configured in response to laser aid
Output and seal the conduit thus limited.
14. equipment as described in claim 1, which is characterized in that the housing is constructed so as to be operatively engaged with it
The flow control apparatus is that can remove or can replace relative to the housing.
15. equipment as described in claim 1, which is characterized in that the flow control apparatus is arranged in be limited by the housing
The intracavitary.
16. equipment as claimed in claim 15, which is characterized in that the housing limits and the outlet from the pipe fitting
The opposite hole of the flow control apparatus at end, the hole are in fluid communication with the chamber so as to which aqueous humor be allowed to flow out to institute by it
State external position.
17. equipment as described in claim 1, which is characterized in that the catheter configurations are can be in response to being pre-selected described
Pressure below intraocular pressure and shrink, with reduce flow or increase to the aqueous humor by the conduit to the external position
The resistance of flowing and so that intraocular pressure is increased to no more than the pressure being pre-selected.
18. equipment as described in claim 1, which is characterized in that further include the anchoring dress operationally engaged with the housing
It puts, the anchoring device is configured to engage eyes under conjunctiva so as to which the housing at least is fastened to eyes.
19. equipment as described in claim 1, which is characterized in that the catheter configurations prevent flow of aqueous humor normally to narrow
Through it.
20. article as described in claim 1, which is characterized in that the flow control apparatus is made of the material of bio-compatible.
21. article as described in claim 1, which is characterized in that the restriction conduit of at least described flow control apparatus
Part is made of polyurethane or silicones.
22. a kind of method manufactured for reducing or stablizing the equipment of intraocular pressure from ocular drainage aqueous humor, eyes have
Anterior chamber and the external ocular for including cornea, the corneal limbus of surrounding and the eyes under eyelid pass through the cornea around described
Edge, the cornea are continuous with Scleral shell and conjunctiva layer, the method includes：
It combines the port of export of pipe fitting with the chamber limited by housing to be in fluid communication, the port of export is extended to suitable for the institute with eyes
The arrival end of anterior chamber's fluid communication is stated, the pipe fitting is suitable for guiding from the anterior chamber and by the arrival end and to described
The flow of aqueous humor of the port of export so that flow of aqueous humor is received by the chamber；And
Distensible flow control apparatus is made to be engaged with the housing, the distensible flow control apparatus is suitable for control from institute
The aqueous humor flowing of the position outside chamber to anterior chamber is stated, and is limited to the conduit connected between the chamber and the external position,
The conduit can be expanded in response to the intraocular pressure more than the pressure being pre-selected, to increase flow or reduce to by described
Conduit to the flowing of the aqueous humor of the external position resistance and so that intraocular pressure is reduced to is pre-selected no more than described
Pressure.
23. method as claimed in claim 22, which is characterized in that including filter for installation to be arranged as to the institute in the pipe fitting
It states and is in fluid communication between arrival end and the flow control apparatus, for being filtered before the flow control apparatus from aqueous humor
Pollutant.
24. method as claimed in claim 23, which is characterized in that including making the filter for installation described in the pipe fitting
It is engaged after the port of export with the housing so that the flow control apparatus is removable or replaceable relative to the housing
, so as to which the filter for installation be allowed to be removed and replaced.
25. method as claimed in claim 22, which is characterized in that including the filter for installation engagement is made to be and the flowing
Control device is in fluid communication, opposite with the port of export of the pipe fitting from the flow control apparatus, comes for filtering
From any to the pollutant of the reflux of the flow control apparatus.
26. method as claimed in claim 25, which is characterized in that including making the filter for installation with the housing described
It is engaged after flow control apparatus so that the filter for installation being engaged with it is removable or replaceable relative to housing
's.
27. method as claimed in claim 22, which is characterized in that distensible flow control apparatus is made to be engaged with the housing
Including the distensible flow control apparatus is made to be engaged with the housing, wherein, the flow control apparatus is limited to described
The multiple conduits connected between chamber and the external position, and at least one of wherein described conduit is expansible.
28. method as claimed in claim 27, which is characterized in that make the distensible flow control apparatus and the housing
Engagement includes the distensible flow control apparatus is made to engage with the housing, wherein, the flow control apparatus restriction is set
It is set to multiple conduits that are parallel and being connected between chamber and external position.
29. method as claimed in claim 22, which is characterized in that distensible flow control apparatus is made to be engaged with the housing
Including the distensible flow control apparatus is made to be engaged with the housing, wherein, the conduit is included with being limited by the housing
Single ingress port that the fixed chamber is in fluid communication and respectively pass through pair that extends from the ingress port with the ingress port
Answer multiple outlet ports of passage.
30. method as claimed in claim 29, which is characterized in that make the distensible flow control apparatus and the housing
Engagement includes the distensible flow control apparatus is made to engage with the housing, wherein, the channel is from the single entrance
Port extends radially outwardly so that the outlet port is angularly spaced around the ingress port.
31. method as claimed in claim 22, which is characterized in that the flow control apparatus is including first part and complementally
The second part of construction, the first part limit the single arrival end being in fluid communication with the chamber limited by the housing
Mouthful, and the second part limits multiple outlet ports, and wherein, and the method includes making the first part and described the
The engagement of two parts to limit liquid storage device between them, and cause each outlet port and the ingress port via
The reservoir fluid connects.
32. method as claimed in claim 22, which is characterized in that including making the defeated of the flow control apparatus and laser aid
Go out engagement so as to form additional distensible conduit in the flow control apparatus.
33. method as claimed in claim 22, which is characterized in that including making the defeated of the flow control apparatus and laser aid
Go out engagement so as to seal the conduit limited by the flow control apparatus.
34. method as claimed in claim 22, which is characterized in that make the distensible flow control apparatus and the housing
Engagement includes the distensible flow control apparatus being inserted into the chamber limited by the housing.
35. a kind of be used for from ocular drainage aqueous humor for reducing or stablizing the equipment of intraocular pressure, eyes have anterior chamber and wrap
The external ocular of cornea, the corneal limbus of surrounding and the eyes under eyelid is included, passes through the corneal limbus around described, the cornea
It is continuous with Scleral shell and conjunctiva layer, the equipment includes
Pipe fitting, the pipe fitting extend between arrival end and the port of export, and the arrival end is suitable for anterior chamber's fluid with eyes
Connection, and the pipe fitting is suitable for guiding flow of aqueous humor from the anterior chamber and passes through the arrival end to the stream of the port of export
It is dynamic；
Flow control apparatus, the flow control apparatus are operatively engaged with the outlet port, and construct in order to control from
The flowing of the aqueous humor of position outside the pipe fitting to the anterior chamber, the flow control apparatus be limited to the port of export with it is outer
The conduit connected between portion position, the conduit can be expanded in response to the intraocular pressure more than the pressure being pre-selected, to increase
Add flow or reduce to by the conduit to the resistance of the flowing of the aqueous humor of the external position and so that intraocular pressure reduction
To no more than the pressure being pre-selected；
First filter device, the first filter device are arranged as controlling with the flowing in the arrival end of the pipe fitting
It is in fluid communication between device processed, the first filter device is configured to the filtering before the flow control apparatus and comes from aqueous humor
Pollutant；And
Second filter for installation, second filter for installation be arranged as with the flow control apparatus be in fluid communication, with from
The port of export of the pipe fitting of the flow control apparatus is opposite, and second filter for installation is configured to filtering and is arrived from any
The pollutant of the reflux of the flow control apparatus.
36. equipment as claimed in claim 35, which is characterized in that go out described in the first filter device and the pipe fitting
The engagement of mouth end, and wherein, the flow control apparatus is operatively engaged with the first filter device so that the stream
Dynamic control device is that can remove or can replace relative to it, so as to which the first filter device be allowed to be removed and replaced.
37. equipment as claimed in claim 35, which is characterized in that second filter for installation and the flow control apparatus
It engages, is opposite with the first filter device, and wherein, the flow control apparatus is constructed so that second filtering
Device device is that can remove or can replace relative to it, so as to which second filter for installation be allowed to be removed and replaced.
38. equipment as claimed in claim 35, which is characterized in that further include the port of export fluid limited with the pipe fitting
The housing of the chamber of connection, the chamber is configured to receive aqueous humor, and the housing is configured to be operatively engaged the flowing control
Device so that the flow control apparatus adjusts the flowing of the aqueous humor from the chamber.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/826,866 US10342702B2 (en) | 2014-08-29 | 2015-08-14 | Apparatus and method for reducing intraocular pressure |
| US14/826,866 | 2015-08-14 | ||
| PCT/US2016/046579 WO2017030902A2 (en) | 2015-08-14 | 2016-08-11 | Apparatus and method for reducing intraocular pressure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108135739A true CN108135739A (en) | 2018-06-08 |
Family
ID=56787701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680058955.XA Pending CN108135739A (en) | 2015-08-14 | 2016-08-11 | Device for lowering intraocular pressure and method for manufacturing such a device |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP3334395A2 (en) |
| JP (1) | JP2018525107A (en) |
| CN (1) | CN108135739A (en) |
| CA (1) | CA2995580C (en) |
| WO (1) | WO2017030902A2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112689488A (en) * | 2018-09-06 | 2021-04-20 | 洛桑联邦理工学院 | Device for treating excess intraocular fluid with an elastic membrane |
| CN114533387A (en) * | 2022-01-14 | 2022-05-27 | 南京普立蒙医疗科技有限公司 | Drainage device for treating glaucoma and manufacturing method |
| WO2023065446A1 (en) * | 2021-10-21 | 2023-04-27 | 首都医科大学附属北京同仁医院 | Split type aqueous humor drainage device |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170360609A9 (en) | 2007-09-24 | 2017-12-21 | Ivantis, Inc. | Methods and devices for increasing aqueous humor outflow |
| EP3334329B1 (en) | 2015-08-14 | 2023-09-13 | Alcon Inc. | Ocular implant with pressure sensor |
| WO2017106517A1 (en) | 2015-12-15 | 2017-06-22 | Ivantis, Inc. | Ocular implant and delivery system |
| EP4371535A3 (en) | 2018-02-22 | 2024-08-14 | Alcon Inc. | Ocular implant |
| DE102018203424A1 (en) * | 2018-03-07 | 2019-09-12 | Carl Zeiss Meditec Ag | Shunt implant |
| JP7547608B2 (en) * | 2020-07-22 | 2024-09-09 | ナショナル ユニバーシティ ホスピタル （シンガポール） ピーティーイー エルティーディー | Eye Drainage Implants |
| JP7220688B2 (en) * | 2020-09-16 | 2023-02-10 | 巨晰光纖股▲ふん▼有限公司 | Diversion support frame for eyeball drainage |
| CA3202776A1 (en) | 2021-01-11 | 2022-07-14 | Wayne A. Noda | Systems and methods for viscoelastic delivery |
| US20220313491A1 (en) * | 2021-04-02 | 2022-10-06 | Twenty Twenty Therapeutics Llc | Passive intraocular pressure control and associated systems, devices, and methods |
| KR102897767B1 (en) * | 2022-07-25 | 2025-12-09 | 주식회사 마이크로트 | Implant device for eye disease with multiple channels and method for manufacturing the same |
| WO2025210416A1 (en) * | 2024-04-03 | 2025-10-09 | Alcon Inc. | Intraocular pressure devices |
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- 2016-08-11 WO PCT/US2016/046579 patent/WO2017030902A2/en not_active Ceased
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| CN112689488A (en) * | 2018-09-06 | 2021-04-20 | 洛桑联邦理工学院 | Device for treating excess intraocular fluid with an elastic membrane |
| CN112689488B (en) * | 2018-09-06 | 2024-04-12 | 洛桑联邦理工学院 | Device for treating excess intraocular fluid with elastic membrane |
| WO2023065446A1 (en) * | 2021-10-21 | 2023-04-27 | 首都医科大学附属北京同仁医院 | Split type aqueous humor drainage device |
| CN114533387A (en) * | 2022-01-14 | 2022-05-27 | 南京普立蒙医疗科技有限公司 | Drainage device for treating glaucoma and manufacturing method |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2995580A1 (en) | 2017-02-23 |
| EP3334395A2 (en) | 2018-06-20 |
| WO2017030902A3 (en) | 2017-06-29 |
| CA2995580C (en) | 2020-03-31 |
| WO2017030902A2 (en) | 2017-02-23 |
| JP2018525107A (en) | 2018-09-06 |
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| CB02 | Change of applicant information |
Address after: North Carolina, USA Applicant after: Alivio Co., Ltd Address before: North Carolina, USA Applicant before: CAMRAS VISION Inc. |
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