CN108135151A - 前列腺癌的啮齿动物模型 - Google Patents

Abstract

本公开提供一种前列腺癌的啮齿动物模型。本文公开的啮齿动物包含转基因，其在小鼠probasin基因的5'和3'调控区的控制下提供致癌蛋白(例如SV40肿瘤抗原)的前列腺特异性表达。所述啮齿动物发展出类似于人前列腺癌的发展的前列腺肿瘤的进展性形式。

Description

前列腺癌的啮齿动物模型

相关申请的交叉引用

本申请要求2015年9月2日提交的美国临时申请号62/213,389的优先权的权益，其全部内容以引用方式并入本文中。

发明领域

本公开涉及一种前列腺癌的啮齿动物模型。本文公开的啮齿动物包含转基因，其包含可操作地连接至小鼠probasin基因的5'和3'调控区的SV40肿瘤抗原编码序列。本文公开的啮齿动物显示出转基因的前列腺特异性表达，并且发展出类似人前列腺癌发展的前列腺肿瘤的进展性形式。

序列表以引用方式并入

序列表为2016年8月24日创建的名称为32350_10161US01_SequenceListing.txt、大小为440KB的ASCII文本文件，其经由EFS-Web提交给美国专利及商标局，并且以引用方式并入本文中。

背景技术

人类疾病的动物模型对理解导致疾病的病理机制并开发有效疗法的重要工具。在美国，仅在今年，前列腺癌就有可能夺走约30,000人的生命，并且超过200,000的人将被新近诊断出患有所述疾病。尽管在本领域中已经描述了前列腺癌的小鼠模型，但是它们各自具有局限性。例如，在大鼠probasin启动子控制下表达SV40肿瘤抗原的转基因小鼠表现出快速的疾病进展，通常在6-12周龄时显示前列腺上皮内瘤形成(“PIN”)并且在18-22周龄显示侵入性癌。此类结果不同于人中癌的特征性缓慢发展。此外，在一些小鼠模型的腹侧叶中已经检测到转基因的显著表达，所述区域不类似于通常产生人前列腺癌的外周区。此外，一些小鼠模型中神经内分泌癌的普遍性也限制了这些模型与神经内分泌疾病患者的小亚群的相关性。

因此，存在对如实地重演人前列腺癌的病理特征的前列腺癌的改进动物模型的需要。

发明内容

本公开提供一种前列腺癌的新颖啮齿动物模型。本文公开的啮齿动物利用小鼠probasin基因的5'和3'调控区来指导致癌蛋白诸如SV40肿瘤抗原或Myc的前列腺特异性表达。啮齿动物发展出重演人前列腺癌的发展和进展的前列腺肿瘤的进展性形式。

在一方面，本公开提供一种啮齿动物，其在基因组中包含转基因，其中转基因从5'至3'包含小鼠probasin基因的5'调控区、包含编码致癌蛋白诸如SV40肿瘤抗原或Myc的第一核苷酸序列的核酸以及小鼠probasin基因的3'调控区。5'调控区、包含编码致癌蛋白诸如SV40肿瘤抗原的第一核苷酸序列的核酸以及3'调控区彼此可操作地连接以实现致癌蛋白诸如SV40肿瘤抗原或Myc在啮齿动物中的前列腺特异性表达。

在一些实施方案中，转基因中的5'调控区包含来自小鼠probasin基因座、在小鼠probasin基因的转录起始位点上游的核苷酸序列。在一些实施方案中，转基因中的5'调控区包含来自小鼠probasin基因座、紧邻小鼠probasin基因的转录起始位点上游的核苷酸序列。在某些实施方案中，转基因中的5'调控区包含在小鼠probasin基因的转录起始位点上游(例如，紧邻上游)的至少约5kb、10kb或25kb的序列。在一些实施方案中，5'调控区包含小鼠probasin基因的5'非翻译区(UTR)。在具体的实施方案中，5'调控区包含如SEQ ID NO:6中列出的核苷酸序列。

在一些实施方案中，转基因中的3'调控区包含来自小鼠probasin基因座、在小鼠probasin基因的转录终止位点下游的核苷酸序列。在一些实施方案中，转基因中的3'调控区包含来自小鼠probasin基因座、紧邻小鼠probasin基因的转录终止位点下游的核苷酸序列。在某些实施方案中，3'调控区包含在小鼠probasin基因的转录终止位点下游(例如，紧邻下游)的至少约5kb、25kb或50kb的序列。在一些实施方案中，3'调控区包含小鼠probasin基因的3'非翻译区(UTR)。在具体的实施方案中，3'调控区包含如SEQ ID NO:7中列出的核苷酸序列。

在一些实施方案中，转基因中的编码SV40肿瘤抗原的核酸序列编码SV40大T抗原或其功能活性片段。在一些实施方案中，转基因中的编码SV40肿瘤抗原的核酸序列编码SV40小t抗原或其功能活性片段。在其他实施方案中，编码SV40肿瘤抗原的核苷酸序列编码SV40大T抗原或其功能活性片段，并且还编码SV40小t抗原或其功能活性片段。在具体的实施方案中，编码SV40肿瘤抗原的核苷酸序列包含如SEQ ID NO:1中列出的序列。

在一些实施方案中，转基因还包含报告基因。在具体的实施方案中，报告子是荧光素酶。在具体的实施方案中，报告基因包含如SEQ ID NO:3中列出的核苷酸序列。

报告基因可操作地连接至致癌蛋白(例如，SV40的肿瘤抗原或Myc)编码序列，使得报告蛋白的表达反映了致癌蛋白(诸如SV40肿瘤抗原或Myc)的表达。在一些实施方案中，转基因中的致癌蛋白(例如SV40肿瘤抗原)编码序列经由编码2A肽的核苷酸序列在框内与报告基因连接。在具体的实施方案中，2A肽选自由F2A肽、E2A肽、P2A肽和T2A肽组成的组。在具体的实施方案中，2A肽是包含SEQ ID NO:13的氨基酸序列的T2A肽。

在一些实施方案中，转基因可以包含附加元件，例如选择性标记基因或盒，其允许选择和鉴定具有转基因的啮齿动物细胞。

在一些实施方案中，转基因被整合到啮齿动物基因的异位基因座。在某些实施方案中，转基因的至少1-10个拷贝(即，1、2、3、4、5、6、7、8、9、10个或更多个拷贝)被整合在基因组中的一个或多个异位基因座中。在具体的实施方案中，转基因的多个拷贝(2、3、4、5、6、7、8、9、10个或更多个拷贝)被串联整合在基因组中的一个异位基因座中。在具体的实施方案中，转基因的5个拷贝被串联整合在基因组中的一个异位基因座中。在其他实施方案中，转基因被整合到靶基因座，例如内源性probasin基因座中。

在一些实施方案中，本文提供的啮齿动物是小鼠或大鼠。在具体的实施方案中，啮齿动物是小鼠。在一些实施方案中，啮齿动物是选自C57BL品系、129品系或其杂交体的品系。在具体的实施方案，啮齿动物是F1H4品系的小鼠，其是C57BL/6和129的杂交体。

在一些实施方案中，本文提供的啮齿动物表现出本文所述的人前列腺癌的表达和病理特征的任何组合，所述表达和病理特征包括例如，表达编码报告子(例如，荧光素酶)和致癌蛋白(例如，SV40T抗原或Myc)的区域、发展出前列腺上皮内瘤形成(PIN)所花费的时间段、前列腺中发展出PIN的区域、发展出前列腺腺癌所花费的时间段、前列腺中发展出腺癌的区域以及发展出的腺癌不是神经内分泌癌的特征。在具体实施方案中，啮齿动物在约4-6月龄时开始在前列腺组织中显示前列腺上皮内瘤形成。在一些实施方案中，啮齿动物在约7-9月龄时开始显示腺癌。在某些实施方案中，啮齿动物中发展出的腺癌不是神经内分泌癌。

在另一方面，本公开提供从本文提供的啮齿动物分离的细胞或组织。可从其分离出细胞的啮齿动物组织包括例如胸腺、脾、胃肠、肝脏、肺、膀胱以及前列腺。

在还另一方面，本公开提供在基因组中包含转基因的啮齿动物胚胎干(ES)细胞，其中转基因从5'至3'包含小鼠probasin基因的5'调控区、编码致癌蛋白诸如SV40肿瘤抗原或Myc的核酸以及小鼠probasin基因的3'调控区，其中5'调控区、编码致癌蛋白诸如SV40肿瘤抗原或Myc的核酸以及3'调控区彼此可操作地连接。在一些实施方案中，啮齿动物ES细胞是小鼠ES细胞或大鼠ES细胞。

在另一方面，本公开提供一种用于制备前列腺癌的啮齿动物模型的方法，所述方法包括将转基因引入到啮齿动物ES细胞的基因组中，所述转基因从5'至3'包含小鼠probasin基因的5'调控区、编码致癌蛋白诸如SV40肿瘤抗原或Myc的核酸以及小鼠probasin基因的3'调控区，其中5'调控区、编码致癌蛋白诸如SV40肿瘤抗原或Myc的核酸以及3'调控区彼此可操作地连接；并且选择在基因组中包含转基因的修饰啮齿动物ES细胞；在桑椹胚前期(premorula stage)时将修饰啮齿动物ES细胞引入到啮齿动物的宿主胚胎中；将宿主胚胎植入到代理孕母体(surrogate mother)中；并且获得前列腺癌的啮齿动物模型。

附图说明

本申请文件包含至少一个用彩色表现的附图。本专利带有彩色附图的副本将会根据要求且在支付必要的费用后由专利及商标局提供。

图1示出了在制备前列腺癌的小鼠模型中使用的转基因及其组件的示例。转基因从5'至3'包含来自小鼠probasin基因的约51kb的5'调控区、编码SV40肿瘤抗原的核酸序列、编码T2A肽的核酸序列、编码萤光素酶报告子的核酸序列、新霉素选择盒以及来自小鼠probasin基因的约107kb的3'调控区。

图2示出了对Luci-TRAMP ES克隆A-C10(5x)的鉴定和衍生自ES克隆的小鼠中转基因的前列腺特异性表达。使用定量PCR(qPCR)和针对T-抗原和荧光素酶转基因设计的测定来评估转基因mRNA。从8周龄小鼠收获组织并将所述组织立即浸入RNALater试剂中。通过Regeneron DNA Core提取总RNA，并且根据稍作修改的PerkinElmer说明书进行qPCR。WT，杂交非转基因对照小鼠；A-B1，具有低/无转基因表达的小鼠；A-B8，具有中等但错误表达转基因的小鼠；A-C10，仅具有在背外侧前列腺(DLP)以及前叶前列腺(AP)和精囊(SV)中表达的～5个转基因拷贝的Luci-TRAMP小鼠。从左至右，由图中条形表示的组织次序是DLP、AP和SV、膀胱、肝脏、肺、肾脏、心脏、胸腺和唾腺。

图3A-3C示出了Luci-TRAMP小鼠在其寿命内的若干个年龄处的纵向体内生物发光成像。在图3A中，F1H4WT对照小鼠随着其长大未表现出任何生物发光，而luci-TRAMP小鼠随着其长大在其腹部区域中显示生物发光增加。图3B是这种腹部生物发光的代表性实例(小鼠ID#1255743)，并且在11月龄时，萤光素酶基因的双侧泌尿生殖表达是非常明显的。WTF1H4对照未显示出生物发光，而第二对照小鼠(R26-L-Luc2)在所有器官中且在所有年龄时都显示出生物发光，这是因为荧光素酶基因是由普遍存在的ROSA26(R26)启动子表达的。图3C示出了在肺中以及可能的肝脏和骨髓(BM)中对萤光素酶基因的检测。使用指定的组织进行qPCR测定(与图2中所述相同)，并且结果显示与任一对照品系肺相比，在Luci-TRAMP肺中检测到显著的T抗原转基因信号。来自Luci-TRAMP BM和肝脏的信号低于肺，但与对照组织相比具有统计显著性。荧光素酶qPCR结果证实与F1H4肺相比，来自Luci-TRAMP肺的信号具有统计显著性。骨髓和肝脏信号高于WT组织，但没有达到统计学显著性。来自R26-L-Luc2小鼠的结果覆盖了来自Luci-TRAMP小鼠的信号，并且从图中删掉。

图4A-4B是Luci-TRAMP和野生型小鼠的背外侧叶的石蜡切片的代表性苏木精/曙红染色图像。图4A示出了来自luci-TRAMP小鼠的背外侧前列腺叶的前列腺上皮内瘤形成(PIN级别被列在每个子图的标记中)。到8月龄时，增生已经进展为腺癌，但是具有完整的基底边界。到11月龄时，前列腺的基质越来越多地被基质细胞浸润(可能是免疫性的)。相比之下，WT F1H4前列腺在11-16月龄时显示出一些与年龄相关的增生，但从未达到luci-TRAMP前列腺的程度。图4B示出了与WT对照小鼠中类似的正常前列腺上皮细胞相比，luci-TRAMP前叶从高级别PIN到腺癌的类似进展。

图5A-5B证实，在Luci-TRAMP小鼠中发展出的前列腺肿瘤是上皮肿瘤，而不是神经内分泌肿瘤。图5A示出了使用抗E-钙粘蛋白抗体的前列腺组织样品的免疫染色。棕黑色沉积物指示抗体与由腔上皮细胞表达的蛋白质特异性反应的位置。图5B示出了使用抗突触小泡蛋白抗体的前列腺组织样品的免疫染色。胰腺中的棕色反应产物指示是神经内分泌性质的胰岛细胞。相比之下，F1H4WT和任一叶(DLP或AP)的luci-TRAMP前列腺均未显示出特定的棕色反应产物。根据标准程序进行免疫组织化学方案：对石蜡切片进行切割、去石蜡化并使其与所指出抗体反应。将针对一抗的宿主并与辣根过氧化物酶偶联的二抗用于扩增特异性相互作用。将DAB[图5B]用于可视化免疫复合物。

SEQ ID NO:1-17总结如下，并且将序列在本公开内容的结尾列出。

1 SV-40T抗原编码序列(编码大T和小t抗原)

2 T2A编码序列

3 荧光素酶编码序列

4 SV-40晚期poly(A)序列

5 新霉素选择盒

6 小鼠probasin基因的51kb 5'调控区序列

7 小鼠probasin基因的107kb 3'调控区序列

8 SV40大T抗原的氨基酸序列(GenBank：AAB59924.1)

9 SV40小t抗原的氨基酸序列(GenBank：AAB59925.1)

10 肽F2A的氨基酸序列

11 肽E2A的氨基酸序列

12 肽P2A的氨基酸序列

13 肽T2A的氨基酸序列

14 LXCXE基序

15 SV40标签-T2A-荧光素酶(Luciferse)转基因的完整核苷酸序列

16 小鼠probasin基因的包含5'非翻译区(5'UTR)的5'序列

17 小鼠probasin基因的包含3'非翻译区(3'UTR)的3'序列

具体实施方式

本公开提供一种前列腺癌的新颖啮齿动物模型。本文公开的啮齿动物含有转基因，其包含可操作地连接至小鼠probasin基因的5'和3'调控区的编码致癌蛋白(诸如SV40肿瘤抗原或Myc)的致癌基因或核苷酸序列。啮齿动物显示出转基因的前列腺特异性表达，并且发展出类似于人前列腺癌发展的前列腺肿瘤的进展性形式。

基于由大鼠probasin启动子驱动SV40肿瘤抗原表达的前列腺癌的转基因小鼠模型已在本领域中有所描述。然而，这些转基因小鼠模型有许多限制。例如，转基因小鼠通常具有快速的疾病进展，通常在6-12周龄时显示前列腺上皮内瘤形成(“PIN”)并且在18-22周龄显示侵入性癌。结果不同于人中癌的特征性缓慢发展。此外，在一些小鼠模型的腹侧叶中已经检测到转基因的显著表达，所述区域不类似于通常产生人前列腺癌的外周区。此外，一些小鼠模型中神经内分泌癌的普遍性也限制了这些模型与神经内分泌疾病患者的小亚群的相关性。

与现有小鼠模型相比，本文公开的啮齿动物更好地重演了在人前列腺癌中发生的病理事件。例如，在本文提供的啮齿动物中前列腺的背外侧叶中检测到转基因的主要表达，所述区域类似于人前列腺的通常产生人前列腺腺癌的外周区。此外，本文提供的啮齿动物发展出类似于人前列腺肿瘤的各个阶段的前列腺肿瘤的进展性形式，所述各个阶段为从增生至高级别前列腺上皮内瘤形成(或“HGPIN”)至侵入性腺癌，与本领域报道的转基因小鼠相比具有慢得多的疾病进展速度和更长的寿命。此外，本文公开的啮齿动物中发展出的腺癌不是神经内分泌性质的。

尽管无意于受任何特定理论的束缚，但据信包含在转基因中以指导SV40肿瘤抗原的表达的小鼠probasin基因的5'调控区和/或3'调控区可能是观察到本公开啮齿动物模型的优点的重要因素。

转基因

术语“转基因”包括经基因工程化以引入到受体生物体的染色体或染色体外DNA的核酸分子。“转基因”还包括整合到生物体的染色体或染色体外DNA中的外源核酸。

用于产生转基因啮齿动物的本文公开的转基因从5'至3'包含彼此可操作地连接的小鼠probasin基因的5'调控区、编码SV40肿瘤抗原的核酸序列以及小鼠probasin基因的3'调控区，以实现SV40肿瘤抗原在啮齿动物中的前列腺特异性表达。

在一些实施方案中，转基因包含附加元件，诸如报告基因和选择性标记基因等等。

术语“可操作地连接”包括核酸元件以功能性关系进行的连接。当核酸序列与另一个核酸序列处于功能性关系中时，所述核酸序列为“可操作地连接”的。例如，如果启动子或增强子或含有启动子或增强子的5'调控区影响编码序列的转录，则其与编码序列可操作地连接。在本公开的上下文中，小鼠probasin基因的5'调控区和小鼠probasin基因的3'调控区与编码SV40肿瘤抗原的核酸序列可操作地连接，以实现编码SV40肿瘤抗原的核酸的转录起始和终止。

本文公开的转基因可以利用已知方法来制备。例如，可以使用细菌同源重组和技术来组装转基因(参见例如U.S.6,586,251和Valenzuela等人,High-throughput engineering of the mouse genome coupled with high-resolutionexpression analysis,2003,Nature Biotech.21(6):652-659)。本文提供的转基因的实例包含如SEQ ID NO:15中列出的核苷酸序列。

适合用于产生前列腺癌的啮齿动物模型的转基因的各种元件在下文中进一步详细地描述。

小鼠probasin基因的5'和3'调控区

Probasin是最初从大鼠分离的前列腺特异性基因。已经显示大鼠probasin(rPB)基因的启动子能够将异源基因特异性地靶向至转基因小鼠中的前列腺(Greenberg等人,Proc.Natl.Acad.Sci.USA 92:3439-3443,1995；Kasper等人,Lab.Invest.78(3):i-xv,1998；Hill等人,Cancer Res.65(22):10243-10254,2005)。在这些研究中，所利用的启动子区限于来自大鼠probasin基因的5'区的相对较短的区段(Greenberg等人(1995)中的454bp区段(-426/+28))；Kasper等人(1998)中的11.5kb片段；和Hill等人(2005)中的458bp区段(-458))。

根据本公开，来自小鼠probasin基因的5'调控区和3'调控区包含在转基因中以指导SV40肿瘤抗原的前列腺特异性表达。

“前列腺特异性表达”意指前列腺中的表达比非前列腺组织和器官中的表达显著更高，或者相比于前列腺中的表达，非前列腺组织和器官中的表达不显著。“显著更高”意指前列腺中的表达比其他组织和器官中的表达高至少50％、100％、200％、300％、400％、500％、600％、700％、800％、900％或1000％。“不显著”意指在每个这样的其他组织中的表达不超过前列腺中表达的20％、10％、5％或1％。

在本文转基因中使用的5'和3'调控区包含存在于小鼠probasin基因的5'上游区和3'下游区中的调控元件，并且足以赋予异源基因诸如SV40肿瘤抗原编码序列的前列腺特异性表达。

术语“调控元件”包括转录调控序列，其包括5'转录调控序列，诸如启动子、增强子和抑制元件，以及3'转录调控序列，诸如转录终止序列。术语“调控元件”还包括可以影响转录效率和转录物稳定性以及翻译起始的5'非翻译区(5'UTR)和3'UTR中的调控序列。

根据本公开，转基因中侧接SV40肿瘤抗原编码序列的5'调控序列包含来自小鼠probasin基因座、在小鼠probasin基因的翻译起始点(或起始密码子ATG)上游的核苷酸序列。在一些实施方案中，转基因中侧接SV40肿瘤抗原编码序列的5'调控序列包含来自小鼠probasin基因座、紧邻小鼠probasin基因的转录起始点(或转录起始位点)上游的核苷酸序列。短语“紧邻转录起始点上游”意指序列(例如，5'调控序列)在小鼠probasin基因的转录起始位点上游并且在所述转录起始位点的35、30、25、20、15、10、5、2或1bp内。在一些实施方案中，转基因中侧接SV40肿瘤抗原编码序列的5'调控序列包含在小鼠probasin基因的转录起始点上游(例如，紧邻上游)的约1kb、2kb、3kb、4kb、5kb、6kb、7kb、8kb、9kb或10kb的序列。在其他实施方案中，侧接SV40肿瘤抗原编码序列的5'序列包含在小鼠probasin基因的转录起始点上游(例如紧邻其上游)的至少10kb、11kb、12kb、13kb、14kb、15kb、16kb、17kb、18kb、19kb或20kb的序列。在还其他实施方案中，侧接SV40肿瘤抗原编码序列的5'调控序列包含在小鼠probasin基因的转录起始点上游(例如紧邻其上游)的至少15kb、20kb、25kb、30kb、35kb、40kb、45kb或50kb的序列。在具体的实施方案中，侧接SV40肿瘤抗原编码序列的5'序列包含在小鼠probasin基因的转录起始点上游(例如紧邻其上游)的至少约45kb、46kb、47kb、48kb、49kb或50kb的序列。

在一些实施方案中，转基因中侧接SV40肿瘤抗原编码序列的5'调控序列还包含小鼠probasin基因的5'UTR序列。在某些实施方案中，侧接SV40肿瘤抗原编码序列的5'序列包含小鼠probasin基因的整个5'UTR序列。在具体的实施方案中，包含在侧接SV40肿瘤抗原编码序列的5'调控序列中的小鼠probasin基因的5'UTR序列包括如SEQ ID NO:16的核苷酸329-469或427-469中列出的核苷酸序列。

在具体的实施方案中，转基因中侧接SV40肿瘤抗原编码序列的5'调控序列包含如SEQ ID NO:6中列出的多核苷酸序列、与其具有基本同一性的序列或其片段。

在比较两个序列的上下文中，“基本同一性”是指主题序列与参考序列具有至少75％、80％、85％、90％、95％、98％或更大的序列同一性。

在某些实施方案中，转基因中侧接SV40肿瘤抗原编码序列的5'调控序列包含如SEQ ID NO:6中列出的多核苷酸序列。在其他实施方案中，侧接SV40肿瘤抗原编码序列的5'调控序列包含SEQ ID NO:6的长度为至少15kb、20kb、25kb、30kb、35kb、40kb、45kb或50kb的片段，优选从SEQ ID NO:6的3'端测量的任何上述长度的片段。

根据本公开，转基因中侧接SV40肿瘤抗原编码序列的3'调控序列包含来自小鼠probasin基因座、在小鼠probasin基因的翻译终止位点下游的核苷酸序列。在一些实施方案中，转基因中侧接SV40肿瘤抗原编码序列的3'调控序列包含来自小鼠probasin基因座、紧邻小鼠probasin基因的转录终止位点下游的核苷酸序列。短语“紧邻转录终止位点下游”意指序列(例如，3'调控序列)在小鼠probasin基因的转录终止位点的上游并且在所述转录终止位点的35、30、25、20、15、10、5、2或1bp内。

在一些实施方案中，转基因中侧接SV40肿瘤抗原编码序列的3'调控序列包含在小鼠probasin基因的转录终止点下游(例如，紧邻其下游)的至少约500bp、约1kb、2kb、3kb、4kb、5kb、6kb、7kb、8kb、9kb或10kb的序列。在具体的实施方案中，侧接SV40肿瘤抗原编码序列的3'序列包含在小鼠probasin基因的转录终止点下游(例如紧邻其下游)的至少10kb、20kb、30kb、40kb、50kb、60kb、70kb、80kb、90kb或100kb的序列。在其他实施方案中，侧接SV40肿瘤抗原编码序列的3'序列包含在小鼠probasin基因的转录终止点下游(例如紧邻其下游)的约100kb、101kb、102kb、103kb、104kb、105kb、106kb或107kb的序列。

在一些实施方案中，侧接SV40肿瘤抗原编码序列的3'序列还包含小鼠probasin基因的3'UTR序列。在某些实施方案中，侧接SV40肿瘤抗原编码序列的3'序列包含小鼠probasin基因的整个3'UTR序列和内含子。在具体的实施方案中，包含小鼠probasin基因的3'UTR和内含子序列的3'序列在SEQ ID NO:17的核苷酸4-3982中列出。

在具体的实施方案中，侧接SV40肿瘤抗原编码序列的3'序列包含如SEQ ID NO:7中列出的多核苷酸序列、与其具有基本同一性的序列或其片段。

在某些实施方案中，侧接SV40肿瘤抗原编码序列的3'序列包含如SEQ ID NO:7中列出的多核苷酸序列。在其他实施方案中，侧接SV40肿瘤抗原编码序列的3'序列包含SEQID NO:7的长度为至少20kb、30kb、40kb、50kb、60kb、70kb、80kb、90kb、100kb或105kb的片段，优选从SEQ ID NO:7的5'端测量的任何上述长度的片段。

SV40肿瘤抗原

在许多实施方案中，编码致癌蛋白的致癌基因或核酸用于本公开中。在一些实施方案中，致癌基因是Myc(Grabowska等人,Cancer Metastasis Rev.2014年9月；33(0):377–397)。在其他实施方案中，致癌蛋白是SV40肿瘤抗原。

猿猴病毒40(SV40)基因组由5243bp组成(参见，例如，GenBank登录号J02400.1)并且被分成三个区：早期编码区、晚编码区和调控区(Ahuja等人,Oncogene 24:7729-7745(2005))。早期编码区编码在生产性感染早期表达的三种蛋白质：大T抗原、小t抗原和17K T抗原(Ahuja等人(2005),同上)。大T抗原和小t抗原由通过从共同的前体mRNA转录物选择性剪接生成的两种mRNA产生(van Santen等人,Nucleic Acid Res.14(24):9911-9926(1986)。已经确立，SV40大T抗原对肿瘤抑制子的p53和成视网膜细胞瘤(Rb)家族的抑制和SV40小t抗原对pp2A磷酸酶的作用对于SV40诱导的转化是重要的(Ahuja等人(2005)，同上)。包括截短的大T抗原的SV40肿瘤抗原在转基因小鼠中的表达导致增生和癌的发展(Ahuja等人(2005),同上；Hill等人,Cancer Res.65:10243-54,2005)。

SV40大T抗原由708个氨基酸组成，并且小t抗原由174个氨基酸组成。大T抗原和小t抗原共享位于蛋白质N末端区中的J结构域。大T抗原具有多个另外的结构域，包括Rb-蛋白结合基序(LXCXE，SEQ ID NO:14)和核定位信号(NLS)。小t抗原具有在J结构域之后的pp2A结合结构域。参见Ahuja等人(2005),同上。

术语“SV40肿瘤抗原”包括全长(即，野生型)SV40大T抗原或其功能活性片段、全长(即，野生型)SV40小t抗原或其功能其活性片段，或其组合。换句话说，转基因中编码SV40肿瘤抗原的核酸序列可编码全长SV40大T抗原或其功能活性片段(无小t抗原)、全长SV40小t抗原或其功能活性片段(无大T抗原)或其组合(例如核酸序列编码SV40大T抗原和SV40小t抗原)。

术语“功能活性片段”是指具有一个或多个与全长(野生型)T抗原相关的功能的T抗原片段；所述功能，例如，全长T抗原的与诱导转化相关或与引发、促进或维持肿瘤形成相关的功能；大T抗原抑制p53或Rb活性的功能；或小t抗原结合和作用于pp2A的功能。T抗原的功能活性片段的实例是Hill等人(2005),同上中描述的截短的大T抗原，其仅包括野生型大T抗原(没有小T抗原)的N末端121个氨基酸，也被称为“T121”。发现包含J结构域和pRb结合结构域的T121突变体抗原在小鼠中足以使pRb家族蛋白失活并产生PIN和腺癌(Hill等人(2005),同上)。

已经描述了其他突变体SV40T抗原也保留了野生型SV40T抗原引起、促进或维持肿瘤形成的功能。例如，由Kasper等人(Lab Invest.78(3):i-xv,1998)描述的SV40基因缺失突变体仅表达大T抗原而不表达小t抗原，并且也发现在小鼠中诱导PIN和腺癌。

根据一些实施方案，转基因中的编码SV40肿瘤抗原的核酸序列编码全长SV40大T抗原或其功能活性片段，而不编码小t抗原。在某些实施方案中，大T抗原包含SEQ ID NO:8的氨基酸序列或与其基本上相同的序列。在具体的实施方案中，编码SV40肿瘤抗原的核酸序列编码包含SEQ ID NO:8的氨基酸序列的大T抗原。在其他具体实施方案中，编码SV40肿瘤抗原的核酸序列编码截短的大T抗原，其包含SEQ ID NO:8的前121个氨基酸。

在一些实施方案中，转基因中的编码SV40肿瘤抗原的核酸序列编码全长SV40小t抗原或其功能活性片段，而不编码大T抗原。在某些实施方案中，小t抗原包含SEQ ID NO:9的氨基酸序列或与其基本上相同的序列。在具体的实施方案中，编码SV40肿瘤抗原的核酸序列编码具有SEQ ID NO:9的氨基酸序列的小t抗原。

在还其他实施方案中，转基因中的编码SV40肿瘤抗原的核酸序列编码全长SV40大T抗原或其功能活性片段和全长SV40小t抗原或其功能其活性片段。在某些实施方案中，编码SV40肿瘤抗原的核酸序列编码全长SV40大T抗原和全长SV40小t抗原。在具体的实施方案中，编码SV40肿瘤抗原的核酸包含SEQ ID NO:1中列出的核苷酸序列或与其基本上相同的核苷酸序列。

报吿子

在一些实施方案中，本文公开的转基因还包含编码提供或能够产生可检测信号的报告蛋白(“报告子”)的报告基因。适用于本公开中的报吿子包括β-半乳糖苷酶、mPlum、mCherry、tdTomato、mStrawberry、J-Red、DsRed、mOrange、mKO、mCitrine、Venus、YPet、黄色荧光蛋白(YFP)、增强型黄色荧光蛋白(EYFP)、Emerald、绿色荧光蛋白(GFP)、增强型绿色荧光蛋白(EGFP)、CyPet、青色荧光蛋白(CFP)、Cerulean、T-Sapphire、萤光素酶、碱性磷酸酶或其组合。

在某些实施方案中，报告子是荧光素酶。术语“荧光素酶”包括催化底物荧光素的氧化反应的氧化酶的种类，并且作为氧化反应的结果发射生物性光。适用于本文中的萤光素酶包括来自萤火虫物种北美萤火虫(Photinuspyralis)的萤火虫荧光素酶、来自其他生物体的萤光素酶，以及其功能性衍生物(诸如通过基因工程技术制备的功能衍生物)。野生型(或天然存在的)萤光素酶的“功能性衍生物”包括与野生型萤光素酶的不同在于具有一个或多个氨基酸修饰(例如，添加、缺失或取代)并且基本上保留野生型萤光素酶的酶活性的蛋白质。短语“基本上保留野生型荧光素酶的酶活性”包括当功能性衍生物和野生型萤光素酶在其酶活性方面进行比较时两个方向上的差异不超过30％、25％、20％、15％、10％、5％、2％或1％。在一些实施方案中，野生型萤光素酶的功能性衍生物具有与野生型荧光素酶的氨基酸序列基本上相同的氨基酸序列。在具体的实施方案中，报告基因编码荧光素酶并且包含如SEQ ID NO:3中列出的核苷酸序列或与SEQ ID NO:3基本上相同的核苷酸序列。

SV40肿瘤抗原编码序列与报吿基因之间的连接

在转基因中报告基因序列被放置成与编码SV40肿瘤抗原的核酸序列可操作地连接，使得报吿子的表达反映SV40肿瘤抗原的表达并且与SV40肿瘤抗原的表达相一致。SV40肿瘤抗原编码序列与报道核酸之间的可操作连接可以本领域中已知的多种方式，诸如通过使用多顺反子表达策略实现。多顺反子表达载体同时表达来自相同mRNA(即，由相同启动子产生的转录物)的两种或更多种单独的蛋白质。用于多顺反子表达蛋白质的合适策略包括使用2A肽和使用内部核糖体进入位点("IRES")。

在一些实施方案中，SV40肿瘤抗原编码序列和报告基因通过编码2A肽的核酸序列彼此连接。可将SV40肿瘤抗原编码序列置于2A肽编码序列的N末端处，并且将报道基因置于2A肽编码序列的C末端处。可替代地，可将SV40肿瘤抗原编码序列置于2A肽编码序列的C末端处，并且将报道基因置于2A肽编码序列的N末端处。

2A肽是小的“自裂解”肽，通常具有18-22个氨基酸的长度。已经证实，核糖体跳过2A肽的C末端处的甘氨酰基-脯氨酰基肽键的合成，这导致2A肽与其紧邻下游肽之间的裂解(Kim等人,PLoS One 2011；6(4):e18556)。因此，“裂解掉”的下游肽在其N末端处具有脯氨酸。2A介导的裂解是所有真核细胞中的普遍现象。2A肽已经从小核糖核酸病毒、昆虫病毒和C型轮状病毒鉴定出(Szymczak等人，"Development of 2A peptide-based strategies inthe design of multicistronic vectors,"Expert Opin Biol Ther 5:627-638(2005))并且适用于本公开中。在某些实施方案中，用于连接SV40肿瘤抗原和报告蛋白的2A肽是选自以下项的2A肽：FMDV 2A("F2A")、马鼻炎A病毒(ERAV)2A("E2A")、猪捷申病毒-1 2A("P2A")或一点褐翅蛾(Thoseaasigna)病毒2A("T2A")。在具体的实施方案中，这些2A肽具有以下序列：

F2A VKQTLNFDLLKLAGDVESNPGP(SEQ ID NO:10)

E2A QCTNYALLKLAGDVESNPGP(SEQ ID NO:11)

P2A ATNFSLLKQAGDVEENPGP(SEQ ID NO:12)

T2A EGRGSLLTCGDVEENPGP(SEQ ID NO:13)

在一些实施方案中，T2A肽被用于提供SV40肿瘤抗原与报告蛋白之间的连接。在一个实施方案中，本文使用的T2A肽包含SEQ ID NO:13的氨基酸序列。在具体的实施方案中，T2A肽由SEQ ID NO:2的核苷酸序列编码。

在其他实施方案中，SV40肿瘤抗原编码序列和报告核酸序列经由内部核糖体进入位点(IRES)彼此连接。IRES是本领域中充分记载的核苷酸序列，其允许在mRNA中间的翻译起始，从而提供来自单个mRNA分子的两种或更多种蛋白质产物的翻译。

转基因中的其他元件

在一些实施方案中，本文提供的转基因还包含编码选择标记的核酸序列。此类选择标记包括但不限于新霉素磷酸转移酶(neo^r)、潮霉素B磷酸转移酶(hyg^r)、嘌呤霉素-N-乙酰转移酶(puro^r)、杀稻瘟素S脱氨酶(bsr^r)、黄嘌呤/鸟嘌呤磷酸核糖转移酶(gpt)或单纯疱疹病毒胸苷激酶(HSV-k)或其组合。

选择标记的核酸可以包含在表达盒中，其中编码选择标记的核酸序列可操作地连接至在所需细胞中具有活性的一种或多种启动子-例如，两个启动子，其中一种在啮齿动物细胞诸如啮齿动物ES细胞中具有活性，并且另一种在细菌细胞中具有活性。

在一些实施方案中，编码选择标记的核酸序列侧接有位点特异性重组靶序列，所述位点特异性重组靶序列允许在整合转基因之后除去位点特异性重组靶序列之间的核酸序列(例如，选择标记核酸)。可侧接选择标记核酸或任何感兴趣的多核苷酸的位点特异性重组靶序列可包括但不限于loxP、lox511、lox2272、lox66、lox71、loxM2、lox5171、FRT、FRT11、FRT71、attp、att、rox及其组合。

在具体的实施方案中，本文提供的转基因包含新霉素选择盒，其从5'至3'含有loxP(5')序列、TATA盒-hUb(人遍在蛋白启动子、EM7启动子、新霉素磷酸转移酶编码序列、polyA序列和loxP(3')序列。在具体的实施方案中，新霉素选择盒包含如SEQ ID NO:5中列出的核苷酸序列或与其基本上相同的序列。一旦选择了包含转基因的ES细胞克隆，就可通过例如经由电穿孔引入Cre重组酶来切除新霉素选择盒。可替代地，可以通过将由ES克隆产生的后代与表达Cre重组酶的删除者啮齿动物品系杂交来除去新霉素选择盒。

在一些实施方案中，本文提供的转基因还包含SV40晚期区poly A序列，其置于SV40肿瘤抗原编码序列的3'侧；并且如果存在报吿核酸，则置于报吿核酸的3'侧。在具体的实施方案中，SV40晚期区poly A序列包含如SEQ ID NO:4中列出的核苷酸序列或与其基本上相同的序列。

前列腺癌的啮齿动物模型

提供了啮齿动物，其在基因组中含有编码SV40肿瘤抗原的转基因，所述转基因可操作地连接至小鼠probasin基因的5'和3'调控区。此类啮齿动物特异性地在前列腺中表达转基因，并且显示出类似于人前列腺癌发展的前列腺肿瘤的进展性形式。

在本领域中已经描述了前列腺癌的转基因小鼠模型。例如，转基因腺癌的小鼠前列腺(TRAMP)模型已得到Greenberg等人(1995),同上,和Gingrich等人(Cancer Res.56:4096-4102,1996)的描述，并且利用前列腺特异性大鼠probasin最小启动子(-427/+28bp)来驱动SV40大T抗原和小t抗原的表达。转基因在TRAMP小鼠的前列腺上皮细胞中特异性表达，与前列腺的背侧叶、外侧叶和前叶相比，在腹侧叶中的表达水平显著更高(Greenberg等人(1995)的图1)。TRAMP小鼠到6-12周龄时发展出前列腺上皮内瘤形成(PIN)，其到20-24周龄时在前列腺的背外侧叶中进展至低分化且侵入性的腺癌(Greenberg等(1995))。在TRAMP小鼠中形成的腺癌显现向远位点(例如淋巴结和肺)的转移(Gingrich等人(1996),同上)，但很少向骨转移。在TRAMP小鼠中发展出的大部分腺癌是神经内分泌起源的(Chiaverotti等人,Am J Pathol.172(1):236–246,2008)，这种类型的癌仅占人前列腺癌患者的10％。TRAMP模型衍生型式得到Hill等人(2005),同上的描述，并且利用截短的大鼠probasin启动子区段(-458bp)，其中两个富含腺嘌呤和尿苷的元件(或“ARE”)被替换以驱动截短的SV40大T抗原的表达。转基因在前列腺的背侧叶、前叶和腹侧叶中表达。这种TRAMP衍生型式小鼠到2月龄时发展出PIN，其到4月龄时进展至癌。前列腺癌的LADY转基因小鼠模型得到Kasper等人(1998),同上的描述，并且利用较大的(11.5kb)大鼠probasin启动子区段以驱动截短的SV40大T抗原，从而导致前列腺中的转基因表达。LADY小鼠到5-10周龄发展出腺体增生和PIN，之后到20周发展出高级别上皮发育异常和低分化的腺癌，主要是在前列腺的背外侧叶和前叶中。LADY小鼠很少显现至其他器官的转移。所有这些转基因小鼠模型都具有快速的疾病进展速度，这不同于人中癌的特征性缓慢发展。TRAMP小鼠中神经内分泌癌的普遍性也限制了这种小鼠模型与神经内分泌疾病患者的小亚群的相关性。

本文提供的啮齿动物比现有技术中描述的模型更好地重演人前列腺癌的病理特征。例如，在啮齿动物的背外侧叶中检测到转基因的主要表达，所述区域类似于人前列腺的通常产生人前列腺腺癌的外周区。此外，本文提供的啮齿动物发展出类似于人前列腺癌的各个阶段的前列腺肿瘤的进展性形式，所述各个阶段为从增生至高级别前列腺上皮内瘤形成(或“HGPIN”)至腺癌，与本领域报道的TRAMP和LADY小鼠相比具有慢得多的疾病进展速度和更长的寿命。此外，本文公开的啮齿动物中发展出的腺癌不是神经内分泌性质的。

在一些实施方案中，转基因在啮齿动物的前列腺的背外侧叶和/或前叶中表达。在一些实施方案中，背外侧叶和/或前叶中的转基因的表达高于前列腺的腹侧叶中的表达。在具体的实施方案中，转基因在背外侧叶、前叶或在组合的背外侧叶和前叶中的表达比在腹侧叶的表达显著更高(即，高至少30％、40％、50％、75％、100％或更多)。

本文提供的啮齿动物发展出前列腺上皮内瘤形成或"PIN"。PIN通常特征为预先存在的腺体空间内非典型细胞的增殖，但未侵入(即尚未破坏基底膜)。在一些实施方案中，啮齿动物在约3-7月龄或约4-6月龄时开始显示PIN。在某些实施方案中，啮齿动物在至少约2、3、4、5或6月龄之前未显示PIN。在一些实施方案中，啮齿动物中发展出的PIN位于前列腺的背外侧叶，或背外侧叶和前叶中。在具体的实施方案中，啮齿动物中发展出的PIN基本上位于前列腺的背外侧叶和/或前叶中，但基本上不在前列腺的腹侧叶中。术语“基本上”意指显示PIN的区域的至少50％、60％、70％、80％、90％或更多位于前列腺的背外侧叶和/或前叶中，而显示PIN的区域的不超过50％、40％、30％、20％、10％或更少位于在前列腺的腹侧叶中。

本文提供的啮齿动物发展出前列腺腺癌。腺癌通常特征为非典型细胞的浸润性和/或破坏性增殖。一般来说，非典型细胞具有一定程度的腺体分化。在一些实施方案中，啮齿动物在约7-9月龄或在约8月龄时开始显示前列腺腺癌。在某些实施方案中，啮齿动物在至少约6、7、8、9或10月龄之前未显示腺癌。在一些实施方案中，啮齿动物中发展出的腺癌位于前列腺的背外侧叶，或背外侧叶和前叶中。在具体的实施方案中，啮齿动物中发展出的腺癌基本上位于前列腺的背外侧叶和/或前叶中，但基本上不在前列腺的腹侧叶中。术语“基本上”意指显示腺癌的区域的至少50％、60％、70％、80％、90％或更多位于前列腺的背外侧叶和/或前叶中，而前列腺中显示腺癌的区域的不超过50％、40％、30％、20％、10％或更少位于在前列腺的腹侧叶中。

在一些实施方案中，在另一个器官中检测到报吿基因(例如，荧光素酶基因)。在具体的实施方案中，在选自以下项的器官中检测到报告基因：膀胱、肝脏、肺、肾脏、心脏、胸腺、唾液腺、骨或其组合。

在一些实施方案中，本文提供的啮齿动物中发展出的腺癌不是神经内分泌癌。神经内分泌(NE)癌与不同的形态学和标记表达模式相关(Chiaverotti等人(2008),同上)。例如，NE癌以低分化和高侵入性病变为特征；形成扭曲导管结构的大团块，包埋正常或增生性腺体，通常涉及多个叶；并且常常有大面积的坏死。在免疫染色测定中，NE癌通常针对雄激素受体(AR)的染色呈阴性或显示出针对AR的微弱且弥散性的细胞质染色，但针对突触小泡蛋白的染色呈阳性，这与针对突触小泡蛋白的染色呈阴性并针对AR具有强核染色的正常和增生性前列腺上皮细胞形成鲜明对比。在具体的实施方案中，本文提供的啮齿动物中发展出的腺癌不表达突触小泡蛋白，即针对突触小泡蛋白的染色呈阴性，如通过免疫染色确定的，但是针对上皮标记E-钙粘蛋白呈阳性。

在一些实施方案中，本文提供的啮齿动物表现出上述的表达和病理特征的任何组合，所述表达和病理特征包括例如，表达转基因的区域、发展出PIN所花费的时间段、前列腺中发展出PIN的区域、发展出前列腺腺癌所花费的时间段、前列腺中发展出腺癌的区域以及发展出的腺癌不是神经内分泌癌的特征。在许多实施方案中，啮齿动物可以表现出以下特征中的任一个的组合：(i)在前列腺的背外侧叶和/或前叶中表达转基因；(ii)在至少约2、3、4、5或6月龄之前未显示PIN，并且在具体的实施方案中，在约3-7月龄或约4-6月龄时开始显示PIN；(iii)在前列腺的背外侧叶，或背外侧和前叶中显示PIN，并且在一些实施方案中，基本上在前列腺的背外侧叶和/或前叶中，但基本上不在前列腺的腹侧叶中显示PIN；(iv)在至少约6、7、8、9或10月龄之前未显示腺癌，并且在具体的实施方案中，在约7-9月龄或约8月龄时开始显示前列腺腺癌；(v)在前列腺的背外侧叶，或背外侧叶和前叶中显示腺癌，并且在具体的实施方案中，基本上在前列腺的背外侧叶和/或前叶中，但基本上不在前列腺的腹侧叶中显示腺癌。在具体的实施方案中，本文公开了一种啮齿动物，其在约4-6月龄时开始在前列腺组织中显示PIN，并且在约7-9月龄时开始显示腺癌，其中在啮齿动物中发展出的腺癌不是神经内分泌癌。

本文提供的啮齿动物与本领域中报道的TRAMP和LADY小鼠相比具有更长的存活时间，这可能是因为本文提供的啮齿动物具有更慢的疾病进展速度并且不发展更具侵袭性的神经内分泌癌。在一些实施方案中，本文提供的啮齿动物至少活到16、18、20、22或24月龄。在具体的实施方案中，啮齿动物存活不长于24月龄。

本文提供的啮齿动物包括例如小鼠、大鼠和仓鼠。在一些实施方案中，啮齿动物是小鼠或大鼠。在具体的实施方案中，啮齿动物是小鼠。

在一些实施方案中，啮齿动物是C57BL品系的，例如选自以下项的C57BL品系的小鼠：C57BL/A、C57BL/An、C57BL/GrFa、C57BL/KaLwN、C57BL/6、C57BL/6J、C57BL/6ByJ、C57BL/6NJ、C57BL/10、C57BL/10ScSn、C57BL/10Cr和C57BL/Ola。在其他实施方案中，啮齿动物是129品系的，例如选自由以下项组成的组的129品系的小鼠：129P1、129P2、129P3、129X1、129S1(例如129S1/SV、129S1/SvIm)、129S2、129S4、129S5、129S9/SvEvH、129/SvJae、129S6(129/SvEvTac)、129S7、129S8、129T1、129T2(参见例如，Festing等人(1999),MammalianGenome 10:836；Auerbach等人(2000),Biotechniques 29(5):1024-1028,1030,1032)。在一些实施方案中，啮齿动物是前述129品系和前述C57BL/6品系的混合体的小鼠。在某些实施方案中，小鼠是前述129品系的混合体(即杂交体)，或前述C57BL品系的混合体，或C57BL品系和129品系的混合体。在某些实施方案中，小鼠是C57BL/6品系与129品系的混合体。在具体的实施方案，小鼠是VGF1品系，也称为F1H4品系，其是C57BL/6和129的杂交体。在其他实施方案中，小鼠是BALB品系，例如BALB/c品系。在一些实施方案中，小鼠是BALB品系和另一种前述品系的混合体。

在一些实施方案中，啮齿动物是大鼠。在某些实施方案中，大鼠选自Wistar大鼠、LEA品系、Sprague Dawley品系、Fischer品系、F344、F6和Dark Agouti。在其他实施方案中，大鼠是选自由Wistar、LEA、Sprague Dawley、Fischer、F344、F6和DarkAgouti组成的组的两个或更多个品系的混合体。

制备转基因啮齿动物的方法

本文提供的啮齿动物可使用本领域中已知的方法形成。在示例性实施方案中，可以构造含有编码SV40肿瘤抗原的转基因的载体，所述转基因可操作地连接至小鼠probasin基因的5'和3'调控区。例如，可以利用细菌人工染色体(BAC)克隆以及细菌同源重组和技术来构造携带所需转基因的BAC载体(参见例如U.S.6,586,251和Valenzuela等人(2003),High-throughput engineering of the mouse genome coupledwith high-resolution expression analysis,Nature Biotech.21(6):652-659)。

在一些实施方案中，可例如通过电穿孔将携带转基因的BAC载体引入到啮齿动物胚胎干(ES)细胞中。本领域已经描述了小鼠ES细胞和大鼠ES细胞。参见，例如US 7,576,259、US 7,659,442、US 7,294,754和US 2008-0078000A1(所有所述专利均以引用的方式并入本文)描述了小鼠ES细胞和用于制备经基因修饰的小鼠的方法；并且US 2014/0235933 A1和US 2014/0310828 A1(所有所述专利均以引用的方式并入本文)描述了大鼠ES细胞和制备经基因修饰的大鼠的方法。

可以选择具有整合在基因组中的转基因的ES细胞。在一些实施方案中，选择了具有整合到啮齿动物的靶基因座中的转基因的ES细胞。靶基因座包括例如内源性啮齿动物probasin基因座(例如经由同源重组介导的整合)。可设计有利于靶向整合的靶向载体并将所述靶向载体用于产生具有靶向整合的转基因的ES细胞。在其他实施方案中，选择具有整合到基因组中的转基因的ES细胞，而不管发生整合的位点如何；换句话说，转基因的一个或多个拷贝可以整合在一个或多个异位位点(即除靶基因座之外的位点)。在一些实施方案中，转基因的至少1-10个拷贝被整合在ES细胞的基因组中。在某些实施方案中，转基因的多个拷贝，例如转基因的2、3、4、5、6、7、8、9、10个或更多个拷贝被整合在ES细胞的基因组中。转基因的多个拷贝可以被整合到基因组的一个基因座或多个基因座中。在具体的实施方案中，转基因的多个拷贝(即，2、3、4、5、6、7、8、9、10个或更多个拷贝)被串联整合到基因组的一个基因座中。随后将具有整合在基因组中的转基因的ES细胞用作供体ES细胞以通过使用方法(参见例如US 7,576,259、US 7,659,442、US 7,294,754和US2008-0078000 A1)或US 2014/0235933 A1和US 2014/0310828 A1中描述的方法注射到桑椹胚前期胚胎(例如，8细胞期胚胎)中。孵育包含供体ES细胞的胚胎直至胚泡期，然后植入到代理孕母体中以产生完全源自供体ES细胞的F0啮齿动物。可以使用检测转基因序列的存在的等位基因测定改型(MOA)(Valenzuela等人，同上)，通过对分离自剪尾的DNA进行基因分型来鉴定具有转基因的啮齿动物幼崽。可以基于以下项对转基因阳性的幼崽进行进一步筛选：转基因的前列腺特异性表达(例如前列腺中相对于其他组织和器官中的表达水平，以及在前列腺各个部分中，诸如在背侧叶、外侧叶、前叶和腹侧叶中的表达)，和/或前列腺癌的发展和进展(例如，PIN和癌的发生和进展)。

ES克隆能够产生展示出可如上述那样鉴定的所需表型的啮齿动物。所需表型包括例如基本上在前列腺的背外侧叶和前叶中的转基因的前列腺特异性表达，以及在约4-6月龄时具有PIN的发生并且在约8月龄时具有癌的发生。此类ES克隆可以培养和储存。在一些实施方案中，ES克隆含有整合在靶基因座(例如，内源性probasin基因座)处的转基因的至少一个拷贝。在其他实施方案中，转基因的至少1-10个拷贝被整合在基因组中的一个或多个异位位点处。在一些实施方案中，ES克隆含有整合在基因组中的转基因的多个拷贝，例如转基因的2、3、4、5、6、7、8、9、10个或更多个拷贝。在某些实施方案中，转基因的多个拷贝(2、3、4、5、6、7、8、9、10个或更多个拷贝)被整合到基因组的多个基因座中。在某些其他实施方案中，转基因的多个拷贝被串联整合到基因组的一个基因座，例如一个异位基因座中。在具体的实施方案中，本文提供了命名为克隆A-C10(5x)的小鼠ES克隆，其具有串联整合在基因组的一个基因座中的转基因的五个拷贝，其中转基因包含SV40标签-T2A-萤光素酶的编码序列，其侧接小鼠probasin基因的5'和3'调控区。

在其他实施方案中，转基因啮齿动物可以不使用ES细胞形成。例如，可以基于常规转化方法(例如电穿孔)修饰啮齿动物的非ES细胞(例如成纤维细胞或诱导的多能细胞)的基因组，并且这种非ES细胞的修饰基因组可以通过采用核转移技术转移至合适的受体细胞，例如卵母细胞。然后将修饰的细胞(例如，修饰的卵母细胞)在合适的条件下孕育以形成胚胎。参见，例如Han等人,"Nuclear Transfer in Mouse Oocytes and Embryos",Methodsin Enzymology 476:171-184(2010)，和Zhou等人,"Generation of Fertile Cloned Ratsby Regulating Oocyte Activation",Science 302:1179(2003)。

使用转基因啮齿动物的方法

本文提供的啮齿动物允许开发用于鉴定、诊断和分期前列腺癌的方法，以及更好地理解导致前列腺癌的进展的分子机制。此外，此类啮齿动物可用于筛选和开发用于预防和治疗前列腺癌的治疗剂。

通过以下实施例进一步说明本说明书，所述实施例不应解释为以任何方式具有限制性。所有引用文献(包括贯穿本申请所引用的参考文献、发布的专利和公布的专利申请)的内容特此以引用的方式明确并入。

实施例1.Luci-TRAMP小鼠的产生

本实施例说明转基因小鼠(在本文中也被称为Luci-TRAMP小鼠)的产生，其包含转基因，所述转基因包含SV40肿瘤抗原-T2A-荧光素酶多肽的核酸编码序列，其侧接小鼠probasin基因的5'调控区和3'调控区。

可以经由细菌同源重组和技术来构造含有转基因的载体(参见例如U.S.6,586,251和Valenzuela等人,High-throughput engineering of the mousegenome coupled with high-resolution expression analysis,2003,NatureBiotech.21(6):652-659)。简而言之，利用含有小鼠probasin基因的细菌人工染色体(BAC)克隆RP23-417B18，并且对其进行如下修饰。一个片段，由75个碱基对(bp)的小鼠5'-UTR、SV40-T抗原(没有终止密码子)、接着是T2A序列、NcoI/XhoI/NheI限制性位点和终止密码子和89bp的小鼠3'-UTR组成，由GenScript合成并将其克隆到R6K骨架中进行增殖。使用添加侧翼NcoI和XhoI限制性位点的引物，从Promega质粒(pGL4)扩增萤光素酶2cDNA序列及其自身的pA。将侧接XhoI和NheI位点的新霉素抗性盒，与萤光素酶扩增子共连接到合成片段中。通过上游(75bp)和下游(89bp)的同源序列介导细菌同源重组替换小鼠Pbsn基因(从起始ATG密码子至终止TAG密码子)。在对接合区进行测序以确保重组是无缝的并且进行限制性片段分析以确定修饰BAC的预期大小之后，将BacVec线性化并纯化以用于电穿孔。

将所得的修饰BAC载体用图形绘示于图1中。修饰BAC载体的组件的核苷酸序列在SEQ ID NO:1-7中列出。

将这种修饰BAC载体电穿孔到VGF1(也称为F1H4)C57BL6/129F1杂交体胚胎干(ES)细胞中，以产生具有整合在基因组中的SV40-T2A-萤光素酶转基因的修饰ES细胞。基于对遗传霉素(G418)的抗性选择含有SV40-T2A-萤光素酶转基因的修饰ES细胞。

然后可以将选择的ES细胞克隆用作供体ES细胞并且通过方法显微注射到桑椹胚前期小鼠胚胎中(参见，例如，US 7576259、US 7659442、US 7294754和US 2008-0078000 A1)。孵育包含供体ES细胞的小鼠胚胎直至胚泡期，然后将所述小鼠胚胎植入到代理孕母体中以产生完全源自供体ES细胞的F0小鼠。使用检测转基因序列的存在的等位基因测定改型(MOA)(Valenzuela等人，同上)，通过对分离自剪尾的DNA进行基因分型来鉴定具有转基因的小鼠。针对T抗原和萤光素酶的表达，进一步筛选转基因阳性的小鼠。

克隆A-C10(5x)被鉴定为产生在8周时显示出前列腺特异性转基因表达的小鼠的ES克隆(图2)。使用定量PCR(qPCR)和针对T-抗原和荧光素酶转基因设计的测定来评估转基因mRNA。从8周龄小鼠收获组织并将所述组织立即浸入RNALater试剂中。通过RegeneronDNACore提取总RNA，并且根据稍作修改的PerkinElmer说明书进行qPCR。WT，杂交非转基因对照小鼠；A-B1，具有低/无转基因表达的小鼠；A-B8，具有中等但错误表达转基因的小鼠；A-C10，仅具有在背外侧前列腺(DLP)以及前叶前列腺(AP和精囊(SV)中表达的～5个转基因(trasnsgene)拷贝的Luci-TRAMP小鼠。

实施例2.Luci-TRAMP群组的纵向分析

将从ES克隆A-C10(5x)产生的Luci-TRAMP小鼠被命名为MAID 2319并且用于本实施例中描述的实验中。将在基因组中的Rosa 26基因座处含有转基因"R26-L-luc2"的命名为MAID 2363的小鼠(其以非组织特异性方式表达萤光素酶报告子和野生型小鼠F1H4作为对照。

饲养35只MAID2319小鼠(Luci-TRAMP)的群组，以允许前列腺肿瘤发展，与此同时饲养相等数目的MAID 2363小鼠(R26-L-Luc2)和F1H4小鼠。在2、4、6、8、11和16个月时从每个组取出5只小鼠，分别用于体内荧光素酶成像、μCT扫描(以评估廋肉/脂肪/骨质量)、组织病理学分析(从4个月开始)和分子表型分析(RNA-seq和qPCR)。

对于纵向研究，在每个指定的时间点(下面的插图)，向所有动物皮下给予荧光素(150mg/kg PerkinElmer)，通过异氟烷麻醉，并且在12-14min后，在Lumina XR体内成像系统上扫描。使用Living软件自动绘制具有轮廓周边的ROI，并以5％的阈值计算强度信号(总通量)。

使用BioSearch Technologies和Regeneron的内部搜索参数设计qPCR探针。将组织在TRIzol中均化，并使用氯仿进行相分离。使用miRNeasy微型试剂盒(Qiagen，目录号217004)根据制造商的说明书纯化含有总RNA的水相。使用MagMAX^TMTurbo^TMDNA酶缓冲液和TURBO DNA酶试剂(Life Technologies的Ambion)除去基因组DNA。使用VILO^TM主混合物试剂(Life Technologies的Invitrogen，目录号11755500)将mRNA逆转录成cDNA。使用ABI 7900HT序列检测系统(Applied Biosystems)用基因表达主混合物试剂(Life Technologies的Applied Biosystems，目录号4370074)扩增cDNA。使用β-肌动蛋白作为内部对照基因以归一化任何cDNA输入差异。使用WT(F1H4)肺作为参考样品来计算样品之间mRNA的倍数差异。每个基因型每种组织，N＝5只雄性。使用GraphPad Prism软件(版本3.0)进行统计和图形分析。使用学生未配对t检验分析数据。在P值<0.05下，将结果视作统计上显著的。误差条示出SD。

结果在图3A-3C中示出。由组织病理学分析揭示的前列腺癌进展概述在表1中。mPIN和腺癌的分配基于以下准则。

mPIN：预先存在的腺体空间内非典型细胞的增殖，但没有侵入(即，尚未破坏基底膜)。基于与特定GEM模型相容的形态(非典型)，mPIN分化自上皮增生。mPIN的进展与年龄相关，并且已被证实发展至侵入性癌。分级是基于在1-4的等级上的结构或细胞学异常的增加程度：

mPIN1(上皮增生)＝轻度的核和/或细胞质异型性(与炎症无关)，其中细胞排列为单层或双层。

mPIN2＝两层或更多层的细胞，在簇或乳头状分支中具有核异型性。

mPIN3＝增加/更频密的异型性，具有部分至完全地填充内腔的更广泛乳头状分支。

mPIN4＝显著/频密的异型性，具有高度增生的分支和腺体空间扩张，但没有明显的侵入。

腺癌：具有一定程度的腺体分化的非典型细胞的浸润性和/或破坏性增殖。在小鼠中，基质结缔组织生成和不同程度的间质性炎症与更晚期的病变相关联。

代表性病理染色图像提供在图4A-4B中。来自Luci-TRAMP小鼠的前列腺肿瘤的免疫组织化学分析在图5A-5B中示出。将组织在新鲜制备的4％多聚甲醛中固定过夜，然后石蜡包埋，切片，并用苏木精和伊红染色以进行分期。分别使用针对突触小泡蛋白(Abcam#32127)或E-钙粘蛋白(CellSignaling克隆64E10)的抗体针对神经内分泌或上皮抗原对一些切片进行分析。

这些研究揭示了以下内容。

■从4月龄开始，所有Luci-TRAMP前列腺(每个年龄组5/5只小鼠)在解剖显微镜下可见到前列腺肿瘤发展(在原本透明的前列腺内的实体白色斑点/区域)，在对照中未检测到异常。

■在4个月和6个月时，在每个年龄中分析的3/3Luci-TRAMP小鼠在背外侧叶和前叶中都展示出非侵入性前列腺肿瘤。在每个年龄组中分析的4/4对照小鼠在任何叶中均未显示出异常。

■在8个月和11个月时，每组3/3Luci-TRAMP小鼠在背外侧叶和前叶都展示出前列腺腺癌。在每个年龄组中分析的3/3对照小鼠在任何叶中均显示出很小的异常。

■在16个月时，5/5Luci-TRAMP小鼠在前叶中展示出前列腺腺癌，并且4/4在背外侧叶中检测到前列腺腺癌。

■在Luci-TRAMP小鼠中，腹侧叶显示出微小变化(限于上皮增生)。

■虽然从8月龄开始观察到微侵入，但到16月龄时没有血管侵入的迹象。

■IHC分析显示，Luci-TRAMP前列腺肿瘤针对上皮标记E-钙粘蛋白的染色呈阳性并且针对神经内分泌标记突触小泡蛋白的染色呈阴性。

表1.Luci-TRAMP小鼠前列腺病理综述

WNL＝在正常限值内；NI＝未鉴定的。

序列表

<110> Regeneron Pharmaceuticals, Inc.

<120> 前列腺癌的啮齿动物模型

<130> 32350PCT (10161WO01)

<150> 62/213,389

<151> 2015-09-02

<160> 17

<170> PatentIn 3.5版

<210> 1

<211> 2470

<212> DNA

<213> 人工序列

<220>

<223> 合成多核苷酸：SV-40 T编码序列抗原编码序列

(编码大T抗原和小t抗原)

<400> 1

atggataaag ttttaaacag agaggaatct ttgcagctaa tggaccttct aggtcttgaa 60

aggagtgcct gggggaatat tcctctgatg agaaaggcat atttaaaaaa atgcaaggag 120

tttcatcctg ataaaggagg agatgaagaa aaaatgaaga aaatgaatac tctgtacaag 180

aaaatggaag atggagtaaa atatgctcat caacctgact ttggaggctt ctgggatgca 240

actgaggtat ttgcttcttc cttaaatcct ggtgttgatg caatgtactg caaacaatgg 300

cctgagtgtg caaagaaaat gtctgctaac tgcatatgct tgctgtgctt actgaggatg 360

aagcatgaaa atagaaaatt atacaggaaa gatccacttg tgtgggttga ttgctactgc 420

ttcgattgct ttagaatgtg gtttggactt gatctttgtg aaggaacctt acttctgtgg 480

tgtgacataa ttggacaaac tacctacaga gatttaaagc tctaaggtaa atataaaatt 540

tttaagtgta taatgtgtta aactactgat tctaattgtt tgtgtatttt agattccaac 600

ctatggaact gatgaatggg agcagtggtg gaatgccttt aatgaggaaa acctgttttg 660

ctcagaagaa atgccatcta gtgatgatga ggctactgct gactctcaac attctactcc 720

tccaaaaaag aagagaaagg tagaagaccc caaggacttt ccttcagaat tgctaagttt 780

tttgagtcat gctgtgttta gtaatagaac tcttgcttgc tttgctattt acaccacaaa 840

ggaaaaagct gcactgctat acaagaaaat tatggaaaaa tattctgtaa cctttataag 900

taggcataac agttataatc ataacatact gttttttctt actccacaca ggcatagagt 960

gtctgctatt aataactatg ctcaaaaatt gtgtaccttt agctttttaa tttgtaaagg 1020

ggttaataag gaatatttga tgtatagtgc cttgactaga gatccatttt ctgttattga 1080

ggaaagtttg ccaggtgggt taaaggagca tgattttaat ccagaagaag cagaggaaac 1140

taaacaagtg tcctggaagc ttgtaacaga gtatgcaatg gaaacaaaat gtgatgatgt 1200

gttgttattg cttgggatgt acttggaatt tcagtacagt tttgaaatgt gtttaaaatg 1260

tattaaaaaa gaacagccca gccactataa gtaccatgaa aagcattatg caaatgctgc 1320

tatatttgct gacagcaaaa accaaaaaac catatgccaa caggctgttg atactgtttt 1380

agctaaaaag cgggttgata gcctacaatt aactagagaa caaatgttaa caaacagatt 1440

taatgatctt ttggatagga tggatataat gtttggttct acaggctctg ctgacataga 1500

agaatggatg gctggagttg cttggctaca ctgtttgttg cccaaaatgg attcagtggt 1560

gtatgacttt ttaaaatgca tggtgtacaa cattcctaaa aaaagatact ggctgtttaa 1620

aggaccaatt gatagtggta aaactacatt agcagctgct ttgcttgaat tatgtggggg 1680

gaaagcttta aatgttaatt tgcccttgga caggctgaac tttgagctag gagtagctat 1740

tgaccagttt ttagtagttt ttgaggatgt aaagggcact ggaggggagt ccagagattt 1800

gccttcaggt cagggaatta ataacctgga caatttaagg gattatttgg atggcagtgt 1860

taaggtaaac ttagaaaaga aacacctaaa taaaagaact caaatatttc cccctggaat 1920

agtcaccatg aatgagtaca gtgtgcctaa aacactgcag gccagatttg taaaacaaat 1980

agattttagg cccaaagatt atttaaagca ttgcctggaa cgcagtgagt ttttgttaga 2040

aaagagaata attcaaagtg gcattgcttt gcttcttatg ttaatttggt acagacctgt 2100

ggctgagttt gctcaaagta ttcagagcag aattgtggag tggaaagaga gattggacaa 2160

agagtttagt ttgtcagtgt atcaaaaaat gaagtttaat gtggctatgg gaattggagt 2220

tttagattgg ctaagaaaca gtgatgatga tgatgaagac agccaggaaa atgctgataa 2280

aaatgaagat ggtggggaga agaacatgga agactcaggg catgaaacag gcattgattc 2340

acagtcccaa ggctcatttc aggcccctca gtcctcacag tctgttcatg atcataatca 2400

gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga 2460

acctgaaaca 2470

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<213> 人工序列

<220>

<223> 合成寡核苷酸：T2A编码序列

<400> 2

gagggcagag gaagtctgct aacatgcggt gacgtcgagg agaatcctgg cccc 54

<210> 3

<211> 1653

<212> DNA

<213> 人工序列

<220>

<223> 合成多核苷酸：荧光素酶编码序列(Luc2)

<400> 3

atggaagatg ccaaaaacat taagaagggc ccagcgccat tctacccact cgaagacggg 60

accgccggcg agcagctgca caaagccatg aagcgctacg ccctggtgcc cggcaccatc 120

gcctttaccg acgcacatat cgaggtggac attacctacg ccgagtactt cgagatgagc 180

gttcggctgg cagaagctat gaagcgctat gggctgaata caaaccatcg gatcgtggtg 240

tgcagcgaga atagcttgca gttcttcatg cccgtgttgg gtgccctgtt catcggtgtg 300

gctgtggccc cagctaacga catctacaac gagcgcgagc tgctgaacag catgggcatc 360

agccagccca ccgtcgtatt cgtgagcaag aaagggctgc aaaagatcct caacgtgcaa 420

aagaagctac cgatcataca aaagatcatc atcatggata gcaagaccga ctaccagggc 480

ttccaaagca tgtacacctt cgtgacttcc catttgccac ccggcttcaa cgagtacgac 540

ttcgtgcccg agagcttcga ccgggacaaa accatcgccc tgatcatgaa cagtagtggc 600

agtaccggat tgcccaaggg cgtagcccta ccgcaccgca ccgcttgtgt ccgattcagt 660

catgcccgcg accccatctt cggcaaccag atcatccccg acaccgctat cctcagcgtg 720

gtgccatttc accacggctt cggcatgttc accacgctgg gctacttgat ctgcggcttt 780

cgggtcgtgc tcatgtaccg cttcgaggag gagctattct tgcgcagctt gcaagactat 840

aagattcaat ctgccctgct ggtgcccaca ctatttagct tcttcgctaa gagcactctc 900

atcgacaagt acgacctaag caacttgcac gagatcgcca gcggcggggc gccgctcagc 960

aaggaggtag gtgaggccgt ggccaaacgc ttccacctac caggcatccg ccagggctac 1020

ggcctgacag aaacaaccag cgccattctg atcacccccg aaggggacga caagcctggc 1080

gcagtaggca aggtggtgcc cttcttcgag gctaaggtgg tggacttgga caccggtaag 1140

acactgggtg tgaaccagcg cggcgagctg tgcgtccgtg gccccatgat catgagcggc 1200

tacgttaaca accccgaggc tacaaacgct ctcatcgaca aggacggctg gctgcacagc 1260

ggcgacatcg cctactggga cgaggacgag cacttcttca tcgtggaccg gctgaagagc 1320

ctgatcaaat acaagggcta ccaggtagcc ccagccgaac tggagagcat cctgctgcaa 1380

caccccaaca tcttcgacgc cggggtcgcc ggcctgcccg acgacgatgc cggcgagctg 1440

cccgccgcag tcgtcgtgct ggaacacggt aaaaccatga ccgagaagga gatcgtggac 1500

tatgtggcca gccaggttac aaccgccaag aagctgcgcg gtggtgttgt gttcgtggac 1560

gaggtgccta aaggactgac cggcaagttg gacgcccgca agatccgcga gattctcatt 1620

aaggccaaga agggcggcaa gatcgccgtg taa 1653

<210> 4

<211> 222

<212> DNA

<213> 人工序列

<220>

<223> 合成多核苷酸：SV-40晚期poly (A)序列

<400> 4

cagacatgat aagatacatt gatgagtttg gacaaaccac aactagaatg cagtgaaaaa 60

aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca 120

ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag ggggaggtgt 180

gggaggtttt ttaaagcaag taaaacctct acaaatgtgg ta 222

<210> 5

<211> 2654

<212> DNA

<213> 人工序列

<220>

<223> 合成多核苷酸：新霉素选择盒(LoxP (5') -TATA box-hUb (人

遍在蛋白启动子)-EM7启动子-新霉素-polyA - loxP(3'))

<400> 5

tcgagataac ttcgtataat gtatgctata cgaagttata tgcatggcct ccgcgccggg 60

ttttggcgcc tcccgcgggc gcccccctcc tcacggcgag cgctgccacg tcagacgaag 120

ggcgcagcga gcgtcctgat ccttccgccc ggacgctcag gacagcggcc cgctgctcat 180

aagactcggc cttagaaccc cagtatcagc agaaggacat tttaggacgg gacttgggtg 240

actctagggc actggttttc tttccagaga gcggaacagg cgaggaaaag tagtcccttc 300

tcggcgattc tgcggaggga tctccgtggg gcggtgaacg ccgatgatta tataaggacg 360

cgccgggtgt ggcacagcta gttccgtcgc agccgggatt tgggtcgcgg ttcttgtttg 420

tggatcgctg tgatcgtcac ttggtgagta gcgggctgct gggctggccg gggctttcgt 480

ggccgccggg ccgctcggtg ggacggaagc gtgtggagag accgccaagg gctgtagtct 540

gggtccgcga gcaaggttgc cctgaactgg gggttggggg gagcgcagca aaatggcggc 600

tgttcccgag tcttgaatgg aagacgcttg tgaggcgggc tgtgaggtcg ttgaaacaag 660

gtggggggca tggtgggcgg caagaaccca aggtcttgag gccttcgcta atgcgggaaa 720

gctcttattc gggtgagatg ggctggggca ccatctgggg accctgacgt gaagtttgtc 780

actgactgga gaactcggtt tgtcgtctgt tgcgggggcg gcagttatgg cggtgccgtt 840

gggcagtgca cccgtacctt tgggagcgcg cgccctcgtc gtgtcgtgac gtcacccgtt 900

ctgttggctt ataatgcagg gtggggccac ctgccggtag gtgtgcggta ggcttttctc 960

cgtcgcagga cgcagggttc gggcctaggg taggctctcc tgaatcgaca ggcgccggac 1020

ctctggtgag gggagggata agtgaggcgt cagtttcttt ggtcggtttt atgtacctat 1080

cttcttaagt agctgaagct ccggttttga actatgcgct cggggttggc gagtgtgttt 1140

tgtgaagttt tttaggcacc ttttgaaatg taatcatttg ggtcaatatg taattttcag 1200

tgttagacta gtaaattgtc cgctaaattc tggccgtttt tggctttttt gttagacgtg 1260

ttgacaatta atcatcggca tagtatatcg gcatagtata atacgacaag gtgaggaact 1320

aaaccatggg atcggccatt gaacaagatg gattgcacgc aggttctccg gccgcttggg 1380

tggagaggct attcggctat gactgggcac aacagacaat cggctgctct gatgccgccg 1440

tgttccggct gtcagcgcag gggcgcccgg ttctttttgt caagaccgac ctgtccggtg 1500

ccctgaatga actgcaggac gaggcagcgc ggctatcgtg gctggccacg acgggcgttc 1560

cttgcgcagc tgtgctcgac gttgtcactg aagcgggaag ggactggctg ctattgggcg 1620

aagtgccggg gcaggatctc ctgtcatctc accttgctcc tgccgagaaa gtatccatca 1680

tggctgatgc aatgcggcgg ctgcatacgc ttgatccggc tacctgccca ttcgaccacc 1740

aagcgaaaca tcgcatcgag cgagcacgta ctcggatgga agccggtctt gtcgatcagg 1800

atgatctgga cgaagagcat caggggctcg cgccagccga actgttcgcc aggctcaagg 1860

cgcgcatgcc cgacggcgat gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata 1920

tcatggtgga aaatggccgc ttttctggat tcatcgactg tggccggctg ggtgtggcgg 1980

accgctatca ggacatagcg ttggctaccc gtgatattgc tgaagagctt ggcggcgaat 2040

gggctgaccg cttcctcgtg ctttacggta tcgccgctcc cgattcgcag cgcatcgcct 2100

tctatcgcct tcttgacgag ttcttctgag gggatccgct gtaagtctgc agaaattgat 2160

gatctattaa acaataaaga tgtccactaa aatggaagtt tttcctgtca tactttgtta 2220

agaagggtga gaacagagta cctacatttt gaatggaagg attggagcta cgggggtggg 2280

ggtggggtgg gattagataa atgcctgctc tttactgaag gctctttact attgctttat 2340

gataatgttt catagttgga tatcataatt taaacaagca aaaccaaatt aagggccagc 2400

tcattcctcc cactcatgat ctatagatct atagatctct cgtgggatca ttgtttttct 2460

cttgattccc actttgtggt tctaagtact gtggtttcca aatgtgtcag tttcatagcc 2520

tgaagaacga gatcagcagc ctctgttcca catacacttc attctcagta ttgttttgcc 2580

aagttctaat tccatcagac ctcgacctgc agcccctaga taacttcgta taatgtatgc 2640

tatacgaagt tatg 2654

<210> 6

<211> 51565

<212> DNA

<213> 人工序列

<220>

<223> 合成多核苷酸：51kb 5'臂序列(1-51565)

<400> 6

tcaacatcct taatcatcag gaaaatgcaa atcaaaacaa ccctgagatt ccacctcaca 60

ccagtcagaa tggctaagat caaaaattca ggtgacagca gatgctgccg aggatgtgga 120

gaaagaggaa cactcctcca ttgttggtgg gattgcaagc ttgtacaacc actctggaaa 180

tcagtctggc agttcctcag aaaattggac atagtactac tggaggatcc cgcaatacct 240

cttctgggca tatatccaga agatgtttca accagtaaga aaaacacatg ctccactatg 300

ttcatagcag ccttatttat aatagccaga agctggaaag tatccagatg cccctcaaca 360

gaggaatgga tacagaaaat gtgatacatt tacacaatgg agtactactc agctacgaaa 420

aagaatgaat ttatgaaatt cctaggcaaa tggatggacc tggagggcat catcctgagt 480

gaggtaaccc aatcacaaaa gaactcacac aatatgtact ccctgataag tggatattag 540

cccagaaact tagaataccc aagatataag atacaatttg ctaaacgcat gaaactcaag 600

aagaacaaag accaaagtgt ggacactttg ccccgtctta gaattgggaa caaaacaccc 660

atggaaggag ttacagagac aaaggttgga gctgagacaa aaggatgggc catctagaga 720

ctaacatatc aggggatcca tcccataatc agcttccaaa tgctgacacc actgtgtaca 780

ctagcaagat tttgctgaaa ggacccagat atggctgtct cttctgagac tatgctgggg 840

cctagcaaac acagaagtgg atgctcacag tcagctattg gatggatgac agagctccca 900

atagaggagc tagagaaagt acccaagtag atgaagggat ctgcaatcct ataggtggat 960

caaaaatatg aactaagcaa tacccctctg gagctcgtgt ctctagctgc atatgaatca 1020

gaaaatggcc tagtcggcaa tcaatggaaa gagaggccca ttggttgtcc aaactttata 1080

tgcctcaata caggggaacg ccagggccaa gaagtgggag tgggtgggta ggtgagtgct 1140

tctggaagcc tgttggggac tttctggata acattggaaa tgtaaatgaa ataaataccc 1200

aataataaaa aaagaacatt caaaaaaaaa aaaaaagatc ctaacccaaa acatccatga 1260

tatccaggac ataatgagaa agcaaggtta ttccattata aaaacatttt tttttttagt 1320

atagaataga gtttatatag ggtataggta ggggagttaa gagagtagta gagacagaga 1380

aaggcagaga gaagaagaga atagagaagt agaggccggt catgaccaca tggaaagagg 1440

gggaagggaa tgcagagaaa ggggacacat ggggcaggag agaggcaaga gtgtaagagt 1500

acaaaaccaa atttacacaa tgtttttcca taaatttagc cctacaaagg ataataggtg 1560

gaaaacacca caacaaggag ggaaactaca ccctcaaaaa agcaagaaag taatcttaca 1620

tcaaacccaa aagaaaatag ctacatgaac agaatttcaa ctctaataac aaaaataaca 1680

ggaagcaaaa atggctttta cttaaaatct cttaacatcc acggactcaa ctctccaata 1740

aaaacacata tattaataga ctggatatgt aaacaggacc cagcattttg ctgcatacag 1800

gaaacgcgcc tcagtgacaa agacagatac tacctcagag taaaaggcta gaaaacaatt 1860

ttccaagcaa gtggtcccaa gaaacaagct gtaataacca ttctaatatc aaataaaatt 1920

aacttaatag aaacagattt gtaaaagtgg attaaggaac tccacataaa accagagaca 1980

ctgaaactta tagaggagaa agtagggaaa agcctcgaag atatgggtac aggggaaaaa 2040

ttcctgaata gaacagcaat ggcttgtgct gtaagatcga gagtcaacga atgggacctc 2100

ataaaattgc aaagcttctg caaggaaaaa gacaccatca gtaagacaaa aaggctacca 2160

acagagtggg aaaggatctt tacctattct aaatcagata ggggactaat atccaatata 2220

tataaagaac tcaagaaggt ggactccaga aaattaaata agcccattaa aaatggggct 2280

cagagataaa caaagaattc tcacctgagg aataccgaat ggctgagaag cacttgaaaa 2340

aatgttcaac atccttaatc atcaggaaaa tgcaaatcaa aacaaccctg agattccacc 2400

tcacaccagt cagaatggct aagatcaaaa attcaggtga cagcagatgc tgccgaggat 2460

gtggagaaag aggaacactc ctccattgtt ggtgggattg caagcttgta caaccactct 2520

ggaaatcagt ctggcagttc ctcagaaaat tggacatagt actactggag gatcccgcaa 2580

tacctctcct gggcatatat ccagaagatg tttcaaccag taagaaaaat acatgctcca 2640

ctatgttcat agcagcctta tttataatag ccagaagctg gaaagtatcc agatggccct 2700

caacagagga atggatacag aaaatgtgat acatttacac aatggagtac tactcagcta 2760

ttaaaaagaa tgaatttatg aaattcctag ccaaatggat ggacgtggag ggcatcatcc 2820

tgagtgaggt aacccaatca caaaagaact cacacagtat gtactcactg ataagtggat 2880

attagctcag aaacttagaa tacccaagat ataggataca atttccaaaa cacatgaaac 2940

tcaagaagac caaagaccaa aatatggaca ttttgccctg tcttagaatt gggaacaaaa 3000

cacccatgga aggagctaca gagacaaagt ttggagctga gacgaaaggt tggaccctct 3060

agagactgcc atatccgggg atccatccca taatcagctt ccaatcgctg acaccattgc 3120

atacactagc aagatcttgc tgaaaggacc cagatatagc tgtctcttgt gagactatgc 3180

tggggcctag caaacacaga agtggatgct cacagtcagc tattggatgg atcacagggc 3240

ccccaatgga ggacctagag aaagtaacca aggagctaaa gggatttgca accctataag 3300

tggaacaaca atatgaacta agcattaccc cccagagctc gtgtctctag ctgcatatgt 3360

ataagaagat ggcctagtcg gccatcagtg gaaagagagg cccattggtc gtgcaaactt 3420

tatatgcctc agtacagggg aacagcaggg ccaagaagtc atagtgagag ggttggggag 3480

tgggtggggg agcgtgtggg ggacttttgg gatagcattg gaaatgtaac tgaaataaat 3540

acctaattaa aaaattagaa aatcaaaaaa agaaggtctt tttttttcac aatattaatt 3600

ctactaggct gtacacttac gagatcttca aattctagta tgtttctttt ttctttcttt 3660

tttttaaaga tatatttatt tattttatgt atgtgagtac actgtagctg tcttcagatg 3720

caccagaaga gcgcatcaga tctcattaca gatggtcatg agccaccatg tggttgctgg 3780

gaattgaact caggacctct ggaagagcag ttggttctct taaccgctga gccatctctc 3840

cagcccctct agtatgtttc ttaatctctt tctttacaca tttaaagttt tcattgtaga 3900

gggtttttta accacttttg ttatgtatat tctaaatatt ttattttatt tgagaaactg 3960

gtaagaggag tgtgtccatg atctctttct cagaatgctt gttactcata tgtattaaga 4020

cttatgaatt tgacaagtcc cttccgcttg actcgagccc cgggctacct tgccagcaga 4080

gtcttgccca acacccgcaa gggcccacac gggactcccc acgggatcct aagacctctg 4140

gtgagtggaa cacagcgcct gccccaatcc aatcgcgcgg aacctgagac tgcagtacat 4200

agggaagcag gctacccggg cctgatctgg ggcacaagcc ccttcagctc cactcgagcc 4260

ccgggctacc ttgccagcag agtcttgccc aacacccgca agggcccaca cgggactccc 4320

cacgggatcc taagacctct ggtgagtgga acacaacttc tgccaggagt ctggttcgaa 4380

caccagatat ctgggtacct gccctgcaag aagagagctt gcctgcagag aatactctgc 4440

ccactgaaac taagaagagt gctaccctcc aggtctgctt atagaggcta acagagtcac 4500

ctgaagtaca agctcttaac agagacaact ataacagcta gcttcagaga ttaccagatg 4560

gcgaaaggca aacgtaagaa tcctactaac agaaatcaag accactcacc aacatcagaa 4620

cgcagcactc ccaccccacc tagtcctggg caccccaaca caaccgaaaa tctagaccca 4680

gatttaaaaa catttctcat gatgatgata gaggacatca agaaggactt tcataagtca 4740

cttaaagaat tacaggagag cactgctaaa gagttacagg cccttaaaga aaagcaggaa 4800

aacacagcca aacaggtaga aatcattaaa gaaaaacagg aaaacacatc caaacaggtg 4860

atggaaatga acaaaaccat actagaacta aaagggtaag tagacacaat aaagaaaacc 4920

caaagcgagg caacgctaga gatagaaacc ctaggaaaga gatctggaac catagatgtg 4980

agcatcagca acagaataca agaaatggaa gagagaatct caggagcaga agattccata 5040

gagaacatcg acacaacagt caaagaaaat acaaaatgca aaaggatcct aactcaaaac 5100

atccaggtaa tccaggacac aatgagaaga ccaaacctac ggataatagg aataaatgag 5160

aatgaagatt ttcaacttaa agggccagct aatatcttca acaaaataat agaagaaaat 5220

ttcccaaaca taaaaaaaga catgcccatg atcatacaag aagcctacag aactccaaat 5280

agactggacc agaaaagaaa ttcctcccga cacataataa ttagaacaac aaatgcaata 5340

aataaagata gaatattaaa agcagtaagg gagaaaggtc aagtaacata taaaggaagg 5400

actatcagaa ttacaccaga cttttcacca gagactatga aagccagaag agcctggaca 5460

gatgttatac agacactaag agaacacaaa tgccagccca ggctactata cccggccaaa 5520

ctctcaatta ccatagatgg agaaaccaaa gtattccacg acaaaaacaa attcacacaa 5580

tatctttcca tgaatccagc ccttcaaagg ataataacag aaaagaagca atacaaggac 5640

ggaaatcacg ccctagaaca accaagaaag taatcattca acaaaccaaa aagaagacag 5700

ccacaagaac agaatgccaa ctctaacaac aaaaataaaa ggaagcaaca attacttttc 5760

cttaatatct cttaatatca atggactcaa ttccccaata aaaagacata gactaacaga 5820

ctggctacac aaacaggacc caacattctg ctgcttacag gaaacccatc tcagggaaaa 5880

agacagacac tacctcagag tgaaaggctg gaaaacaatt ttccaagcaa atggactgaa 5940

gaaacaagct ggagtagcca ttttaatatc ggataaaatc gacttccaac ccaaagttat 6000

caaaaaagac agggagggac acttcatact catcaaaggt aaaatcctcc aagaggaact 6060

ctcaattctg aatatctacg caccaaatgc aagggcagcc acattcatta gagacacttt 6120

agtaaaactc aaacatacat tgcacctcac acaataatag tgggagactt caacacacca 6180

ctttcttcaa aggacagatc gtggaaacag aaactaaaca gggacacagt gaaactaaca 6240

gaagttatga aacaaatgga cctgacagat atctacagaa cattttatcc taaaacaaaa 6300

ggatatacct tcttctcagc acctcacggg accttctcca aaattgatca tataattggt 6360

cacaaaacag gcctcaatag atacaaaaat attgaaattg tcccatgtat cctatcagac 6420

caccatggcc taagactgat cttcaataac aacataaata atggaaagcc aacattcacg 6480

tggaaactga acaacactct tctcaatgat accttggtca aggaaggaaa aaagaaagaa 6540

attaaagact ttttagagtt taatgaaaat gaagccacaa cgtacccaaa cctttgggac 6600

acaatgaaag catttctaag agggaaactc atagctctga gtgcctccaa gaagaaacgg 6660

gggacagcac atactagcag cttgacaaca catctaaaag ccctagaaaa aaaggaagca 6720

aattcaccca agaggagtag acggcaggaa ataatcaaac tcaggggtga aatcaaccaa 6780

gtggaaacaa gaagaaatat tcaaagaatt aaccaaacga ggagttggtt ctttgagaaa 6840

atcaacaaga tagataaacc cttagctaga ctcactaaag ggcacaggga caaaatccta 6900

attaacaaaa tcagaaatga aaagggagac ataacaacag atcctgaaga aatccaaaac 6960

accatcagat ccttctacaa aaggctatac tcaacaaaac tggaaaacct ggacgaaatg 7020

gacaaatttc tggacagata ccaggtacca aagttgaatc aggatcaagt tgatcatcta 7080

aacagtccca tatcacctaa agaaatagaa gcagttatta atagtctccc aaccaaaaaa 7140

agcccaggac cagatgggtt tagtgcagag ttctatcaga ccttcaaaga agatctaatt 7200

ccagttctgc acaaactatt tcacaaaata gaagtagaag gtactctacc caactcattt 7260

tatgaagcca ctattactct aatacctaaa ccacagaaag acccaacaaa gagagaactt 7320

cagaccaatt tctcttatga atatcgatgc aaaaatcctc aataaaattc tcgctaacca 7380

aatccaagaa cacattaaag caatcatcca tcctgaccaa gtaggtttta ttccagggat 7440

gcagggatgg tttaatatac gaaaatccat caatgtaatc cattatataa acaaactcaa 7500

agacaaaaac cacatgatca tctcgttaga tgcagaaaac gcatttgaca agatccaaca 7560

cccattcatg ataaaagttt tggaaagatc aggaattcaa ggcccatacc taaacatgat 7620

aaaagcaatc tacagcaaac cagtagccaa catcaaagta aatggagaga agctggaagc 7680

aatcccacta aaatcaggga ctagacaagg ctgcccactt tctccctacc tgcccacttt 7740

ctccctacct tttcaacata gtacttgaag tattagccag agcaattcga caacaaaagg 7800

agatcaaggg gatacaaatt ggaaaagagg aagtcaaaat atcacttttt gcagatgata 7860

tgatagtata tataagtgac cctaaaaatt ctaccagaga acacctaaac ctgataaaca 7920

gcttcggtga agtagctgga tataaaatta actcaaacaa gtcaatggcc tttctctaca 7980

caaagaataa acaggctgag aaagaaatta gggaaacaac acccttctca atagtcacaa 8040

ataatataaa atatcttggc gtgactctaa ctaaggaagt gaaagatctg tatgataaaa 8100

acttcaaatc tctgaagaaa gaaattaagg aagatctcag aagatggaaa gatctcccat 8160

gctcatggat tggcaggatc aacattgtaa aaatggctat cttgccaaaa gcaatctaca 8220

gattcaatgc aatccccatc aaaattccaa ctcaattctc aaacgaattg gaaggagcaa 8280

tttgcaaatt tgtctggaat aacaaaaaac ctaggatagc aaaaagtctt ctcaaggata 8340

aaagaacttc tggcggaatc accatgccag acctaacgct ttactgcaga gcaattgtga 8400

taaaaactgc atggtactgg tatagagaca gacaagtaga ccaatggaat agaattgaag 8460

acccagaaat gaacccacac acctatggtc acttgatctt cgacaaggga gctaaaacca 8520

tccagtggaa gaaagacagc tttttcaaca attagtgctg gcacaactgg ttgatatcgt 8580

gtagaagaat gcgaatcgat ccatacttat ctccttgtac taaggtcaaa tctaagtgga 8640

ttaaggaact tcacataaaa ccagagacac tgaaacttat agaggagaaa gtggggaaaa 8700

gccttgaaga tatgggcaca ggggaaaaat tcctgaacag aacagcaatg gcttgtgctg 8760

taagatcaag aattgacaca tgggacctaa tgaaactcca aagtttctgc aaggcaaaag 8820

acaccgtcaa taagacaaaa agaccaccaa cagattggga aaggatcttt acctatccta 8880

aatcagatag gggactaata tccaacatat ataaagaact caagaaggtg gacttcagaa 8940

aatcaaataa ccccattaaa aaatggggct cagaactgaa caaagaattc tcacctgagg 9000

aataccgaat ggcagagaag cacctgaaaa aatgttcaac atccttaatc atcagggaaa 9060

tgcaaatcaa aacaaccctg agattccacc tcacaccagt cagaatggct aagatcaaaa 9120

atttaggtga aagcagatgt tggcgtggat gtggagaaag aggaacactc ctccattgtt 9180

ggtgggagtg caggcttgta caaccactct ggaaatcagt ctggcggttc ctcagaaaat 9240

tggacatagt actaccggag gatccagcaa tacctctcct gggcatatat ccagaagaag 9300

ccccaactgg taagaaggac acatgctcca ctatgttcat agcagcctta tttataatag 9360

ccagaaactg gaaagaaccc agatgcccct caacagagga atggatacag aaaatgtggt 9420

acatctacac aatggagtac tactcagcta ttaaaaagaa tgaatttatg aaattcctag 9480

ccaaatggat ggacctggag ggcatcatcc tgagtgaggt aacacattca caaagaaact 9540

cacacaatat gtactcactg ataagtggat actagcccca aacctaggat acccaagata 9600

taagatataa tttgctaaac acataaaact caagaagaat gaagactgaa gtgtggacac 9660

tctgcccctc cttagatttg ggaacaaaac acccatggaa ggagttacag agacaaagtt 9720

tggagctgag atgaaaggat ggaccatgta gagactgcca tatccaggga tccaccccat 9780

aatcagcatc caaacgctga caccattgca tacactagca agattttatc gaaaggaccc 9840

agatgtagct gtctcttgtg agactatgcc ggggcctagc aaacacagaa gtggatgctc 9900

acagtcagct aatggatgga tcatagggct cccaatggag gagctagaga aagtagccaa 9960

ggagctaaag ggatctgcaa ccctataggt ggaacaacat tatgaactaa ccagtacccc 10020

ggagctcttg actctagctg catatatatc aaaagatggc ctagtcggcc atcactggaa 10080

agagaggccc attggacttg caaactttat atgccccagt acaggggaac accagggcca 10140

aaaaggggga gtgggtgggt aggggagtgg gggtgggtgg atatggggga cttttggtat 10200

agcattggaa atgtaaatga gctaaatacc taataaaaaa tgggaaaaaa agacttatga 10260

attttataag tcaattatgt atcacaatag ttctctgaaa ttattgataa tttctataat 10320

ttttctagtc aaattttggg aacattgggt aaaaggtaat atgatcttca attgaaaata 10380

attttactta ttatttttct atttgtatcc cttctcttgc cttattgctc cagctaatgc 10440

ttcaatcaca ttatggataa gcagtaggga tagtgagcat tcctttccca ttttgatttt 10500

aatggtgctt attaatgttt tttattaatt taggaagata ttggccatag ttttgacata 10560

cataaccttt attatgttgg aatatatttc ctacagtcct acttgttctt tggcttttat 10620

taaaaagaca tgttgaggcc atcatgggcg cgaactcagt gggccctagc acacccagga 10680

tcttggaatc actggtgagt ggaacgcaac atctgttcca aaaaacccag agggtcttgt 10740

gccagcagga acaaggacaa aggaaacctg ctcaaccagc tgctggggtt tgttcccatt 10800

ggcgccagcc ccatctgatc ttggacgcat actcagcagg ccatagcaca cccagtatct 10860

tgggattact aacaccagtc tgctcaggag agcacataag cagcagaagc aacagagctt 10920

cttggacagg gtcccttcgg gccttcatcc tcagccagga ggcagagctg agacccagac 10980

ccctgggtac cttccccatc agaggagagt tggcctacgg ggagtactct gacctcagaa 11040

ttcaggaggt gaatctgggc tgcagaattc tgtgcacctt tcctgcaaga ggaaagcttg 11100

cctgcagaga gtgctctgac cactgggatt caggaaagtt agtctctcag gagtgctgac 11160

agaggctaaa gaatcacagg aggaacaagc tccagacaga gatagctaca acatctaaca 11220

caagagatta ccagttggtg aaagaaaaac ctaagaatct taataacagg agccaagacc 11280

actcagcatc atcagaaccc agtacaccca ccacagtgtg ttttggatat cccaacacac 11340

ctgaaaagca agactctcat ttaaaatcat atctcatgat ggtggtagaa aattttaaga 11400

atggcattaa taactcactt aaagaaatat aggagaacac tgctaaacag gtaaaaaccc 11460

ttaaagagga aggacaaaaa cccctcaagg aattacagga gaacactgct aaacaggtag 11520

aagcccttaa agaggaaaca caaaaatccc tcaaggaatt acaggagaac atggctaaac 11580

aggtagaagt ccttaaagaa ctacaggcaa acactgctaa acaggtagaa gtccttaaag 11640

aagaaacaca aaaatccctt aaagaattac aggaaaacac aaccaaagag gggatggaat 11700

tgaacaaagc catccaagat ataaaaatgg aagtagaagc aatgaagaaa acccaaaggg 11760

aaacaactct ggagatagaa accctaggaa agaaatcagg aagcatagat gtgaacatca 11820

gcaacagaat acaagagatg gaagagagaa tctcaggtgc agaagattcc atacggaaga 11880

tggacacaac aatcaaagaa aatgcaaaat gcaaaaagat cttaactcaa aacatccagg 11940

aaatccagga caaaatgaga agaccacacc tatggataag aggagtagat gagaatgaag 12000

attttcaact taaagggcca gcaaatatct tcaacaaaat tatagaagaa aacttcccaa 12060

acctaaagaa tgacatgccc atgaacatac aagaagccta cagaactcca aatagactga 12120

accagaaaat aaattcctcc caacacataa taattagaac aacaaatgca ctaaataaag 12180

agagaatatt aaaagcagta agggaaaaag gacaagtaac atataattgc aggcctatta 12240

gaattactcc agacttctta caagagacta tgaaggctag aagatcctgg acagatgtta 12300

cacagacacc aagagaacac aaatgccagc caaggctaat ataaccagca aaactctcaa 12360

ttaccataca tagagaaaca aaggattcca tgacaaaacc aaattcacac aatacctttt 12420

cgtgaatcca gtccttcaaa ggataataaa gggaaaacac caaaacaatg atggaaatta 12480

tgccctagaa aaagcaagaa aataaccctt caacaaaact aaaagaagac agccacaaaa 12540

acagaatgcc aactctaaca acaaaaatga caggaagcaa caattacttt tccttaatat 12600

ctcttaatat caatggattc aattccccaa taaaaagaca tagactaaca gactggctac 12660

ataaacagga ccaacatttt gctgcttaca ggaaacccac ctcatggaaa aagacagaca 12720

ctacctcaga gtgaaaggct ggaaaacaat tttccaagca aatggtccaa agaaacaagc 12780

tggagtatcc attttaatat ctaaaaaaaa tcaacttcca acccaaagtt atcaaaaaag 12840

tcaaggaggg gcacttcata tgcattaaag gtaaaatctt ccaagatgaa ctctcaattt 12900

tgaatatcta tgctccaaat gcaagggcat ccacattcat taaacaatag tatagtaaag 12960

ctcaaaacac atattgcacc tcatacaata atattgggag acttcaacac ccaactgtca 13020

tcaatggaca gatcctggaa acagaatcta aacagagaca cattgaacct agcagaagtt 13080

aggaaacaaa aggatttaac agatatctac agaatatttt atcttaaaac aaaagtatat 13140

accttcttct cagcacctca tggtaccttc tccaaaactg accatataat tggtcacaaa 13200

acaggcctca acagatgtaa aactattgag attatcccat gcatcctatc agatcaccag 13260

ggactaaggc tgatcttcaa taaaaataat aataaatatt agaaagtcaa cattcacgtg 13320

gaagctgaac aacactctac tcaatgatat cttgatcagg gaagaaataa agaaagaaat 13380

taaagacttt ttagagttta atgaaaatga agccacaaca tacccaaact tatgtgacac 13440

aatgaaagca ttcgtaagag gaaaactcat agccctgagt gcctccaaaa agaaactaga 13500

gagaatcata cactaacagc ttgacaacac acctaaaagt tctagaacaa aaggaagcaa 13560

attcacccaa gaggagtaga cagcaagaaa taatcacact cagggttgaa atcaaccaag 13620

tggaaacaaa aagaactgtt cagagaatca accaaaccag gagctggttc tttgagaata 13680

tcaacaagat agataaaccc ttagccagac taactaacgg tcacagggac agtatcctaa 13740

tgaacaaaat cagaaatgaa aagtacccaa ggagctaaga ggttcggcaa ctctatagga 13800

ggatcaacaa tatgaagtaa ccactacccc cacagaactg agtctctagg tgtatatgta 13860

gcagaggatg gcctagtcgg caatcaacag gaggagaggc ccttgggaag attatatgct 13920

ccagtatagg gggtggttaa catgtagaga ttccacctca gaccagtcag aatggctaag 13980

atcaaaaact caggtgacag cagatgctgg catggatgtg gagaaagagg aacactcttc 14040

cattgctggt gggattgcaa gcttgtacaa acactttgga aatcagttta gcggttcatc 14100

agttaattgc acatagtact accggaggat tcagcaatac ctttcctgtg cattggagaa 14160

aacagaaaac tctgagatgg aagctctgct gctggctctt gtgtttgctt ggatttgttc 14220

tagaagtggg tcgaatggac agctcaatga aacccaggta tcatgaaata ataagtataa 14280

tatataaaaa attcttattt cattattcat ttatctcaaa tgctgagcaa cacctcaata 14340

tcatttacta aatatttatg tactagagaa atcactcatt cagggagcaa gtcaggggaa 14400

atgcaacact ctaaatagaa tatgatttaa tatttagttt catatgactt aatatttaat 14460

atttttattt tagacatttt acatttagac tttcacacac acatatatat gtatgtatgc 14520

atatatatat atgtatatgt atataaacag catgcaaact gcaattacaa acattaaaat 14580

ataccagata aaatgttagc cttattatat gcccattgta gtattatgat ttcaaaataa 14640

aataggatat aattacatgt cttcatatta atcactcatg taaaaataat attaaatgtc 14700

agcatctcgt cacctgtgtc tatttatccc tctgttttcc tcaaagagat ttatataaat 14760

gtcagattct gtaaaccgtt ggttcacact catgtctgca ttgaaaacaa atattattta 14820

ctgtcaattt tatattttct catttctatt tagagcagat tttaggtgat aaaacccaga 14880

gaccaaatga aatattttgt tttctgtgat atttgttaac tcagtcttaa atatgtcaaa 14940

agtctttcac cgttatgctt taaatgtaga tttggacaat tgtgtcacct tttgtttgta 15000

cacttcaggg aacagaaaat ttactctgta tttaggaatt gtattattga ttgtatgtca 15060

cactatacaa taaatggaat atgttcaatt gcatttagta atttttattt tttttcctgc 15120

aatacatttt gattgtattc attcctctca actctcagat cttcccccac ctccctacct 15180

acacaaattc atgttctttc tctaacaaaa atatggaata taagtttttt ttgtttttta 15240

tttttttttt tttttgagac agggtttctc tgtgtagccc tagctgtcct ggaactcaat 15300

ctatagacca gactggcctc gaactcagaa attcacctgc ctctgcctgc caagtgctgg 15360

gattaaaggc atgtgccacc actgcccagc tagaatataa gttttttttt aaagattttt 15420

ttatttatta tatgtaagta cactgtagct gtcttcagac actccagaag agggagccag 15480

atcttgttac agatggttgt gagccaccat gtggttgctg ggatttgaac tccggacctt 15540

cggaagagca gtcgggtgct cttacccact gagccatctc accagcccta gaatataagt 15600

tttaaggagc agaattgtat acttctcatt aaaaatcaaa aatttcccct ctcaagctaa 15660

agtatttgtt ggagatgaaa gaaaacatcc atttattttc ctaatggcat cttcattctc 15720

agatctcagg tgattggtac accattgcca tagcagccac agatcttgat gtgatcaccg 15780

atgatggatt gttgaaactg tttttccgtc atcttgagtg tactgaacaa tgcaaagaaa 15840

tcatcctgac attctatggt gagtaagcta accttgctgc aatctaaagg ttcagacatt 15900

ttgatatgat aggaggtatt gacacatttc ccagactgac agtttcatga cactgtcact 15960

taccacaata tatacataat tccaaaatag aaaataatgc tgaggtattg ttccacattt 16020

caaataaaat acatttaata tgaatattta tgaatggtaa tataaacaat attaatatta 16080

ctaaaatatt taatatttat aatgtatgtt tcctatacat ttaaattatt taaaacagca 16140

tgcatattat aatgacaaat gatattcggt atactggata gaatgtatgt catattgtat 16200

atatgattac aatataaatt atgacttaca tttatatatg attacaatat aaaatgagtt 16260

gtatactaca tgtatattaa aatgaacatg ttatgtgtgt acttacaata ttgtatttta 16320

tataatatca tatttcacat taatatcaaa ttttgtggct ctatactaca gaaaatatca 16380

ggctagaaaa aattgctcag tgaataaagt acttttaaat ttatttataa cattgtgtta 16440

ttttatgata acatacacat gtcactatgt aaaaattatt atatttatat gtcatatatc 16500

atactttata ttttaattat acctatatat tattgtttgt tgttaaagat ttgtgtttta 16560

tggtattcct gtttgtgtga aagtgtggat ctctgcatct atatgtgttt cttgtgcttt 16620

ttctttgtct cttgtgtttt ttttttttct gtttctttgc tttgccctca tctggtttgc 16680

ttttatttat ttatttcttg tctttagtat gcattctcat tttctaatga aagaaagtgt 16740

gagaatttgg atgggtggaa aggttgggag gatatggaga tataggaagg gaaaccataa 16800

tcagaacata gtatatggaa atattctttt aattaataaa acgatgggtt ttagttatat 16860

caagtgtctg gaaattagtt ttaaatagtt tttcatagtt ttaattgtta attccagtca 16920

tagaagtggg aagtatttca gatggaaaaa tagcatttgt atcactaagc agcttgtgac 16980

caagaccatt tcagatcttg tgggtaagac tgtcaatcac ccatagctgg aatggttgac 17040

aattaatggc tcctggggga ggaataatta tattacttta agaatatagt cacttgtggg 17100

tttacattca tgcacatatg ttcaatgata actggacata attggttact tctttaaaat 17160

gaaaggagga aagggagaga gaatctggga tttggaagga ctggactaga tgaaggtgga 17220

tccaagtatg ctcttgcatg tatggaattc tcatatgtac agcagtgact ggaagtatat 17280

aaacttcaat agcaataaat tcaggacata tagagaaata ggaaagcaga aacagggggc 17340

tatataagat cacattttat tttatgtgtg tatgggattc tacaaagaaa agttaaagtg 17400

aaatataaaa gtacttaaaa taaattcata gatcagcata caattaggac tagggtaaat 17460

aaagatccca tatcccctaa agaaatagaa gcagttatta atagtctccc agccaaaaaa 17520

agcccaggac cagatgggtt tagtgcagag ttctatcaga ccttcaaaga agatctaatt 17580

ccagttctgc acaaactatt tcacaagata gaagtagaag gtactctacc caactcattt 17640

tatgaagcca ctattactct gatacctaaa ccacagaaag atccaacaaa gatagagaac 17700

ttcagaccaa tttctcttat gaatatcgat gcaaaaatcc ttaataaaat tctcgctaac 17760

cgaatccaag aacacattaa agaaatcatc catcctgacc aagtaggttt tattccaggg 17820

atgcagggat ggtttaatat acgaaaatcc atcaatgtaa tccattatat aaacaaactc 17880

aaagacaaaa accacatgat catctcgtta gatgcagaaa aagcatttga caagatccaa 17940

cacccattca tgataaaagt tttggaaaga tcaggaattc aaggcccata cctaaacata 18000

ataaaagcaa tctacagcaa accagtagcc aacatcaaag taaatggaga gaagctggaa 18060

gcaatcccac taaaatcagg gactagacaa ggttgcccac tttctcccta ccttttcaac 18120

atagtacttg aagtattagc cagagcaatt cgacaacaaa aggagatcaa ggggatacaa 18180

attggaaaag aggaagtcaa aataacactt tttgcagatg atatgatagt atatataagt 18240

gaccctaaaa attccaccag agaactccta aacctgataa acagcttcgg tgaagtagct 18300

ggatataaaa ttaactcaaa caagtcaatg gcctttctct acacaaagaa taaacaggct 18360

gagaaagaaa ttagggaaac aacacccttc tcaatagtca caaataatat aaaatatctc 18420

ggcgtgactc taactaagga agtaaaagat ctgtatgata aaaacttcaa gtctctgaag 18480

aaagaaatta aagaagatct cagaagatgg aaagatctcc catgctcatg gattggcagg 18540

atcaacattg taaaaatggc tatcttgcca aaagcaatct acagattcaa tgcaatcccc 18600

atcaaaattc caactcaatt cttcaacgaa ttagaaggag caatttgcaa attcatctgg 18660

aataacaaaa aacctaggat agcaaaaact cttctcaagg ataaaagaac ctctggtgga 18720

atcaccatgc ctgacctaaa gctttactac agggcaattg tgataaaaac tgcatggtac 18780

tggtatagag acagacaagt agaccaatgg aatagaattg aagacccaga aatgaaccca 18840

cacacctatg gtcacttgat cttcgacaag ggagctaaaa ccatccagtg gaagaaagac 18900

agcattttca acaattggtg ctggcacaac tggttgttat catgtagaag aatgcgaatc 18960

gatccatact tatctccttg tactaaggtc aaatctaagt ggatcaagga acttcacata 19020

aaaccagaga cactgaaact tatagaggag aaagtgggga aaagccttga agatatgggt 19080

acaggggaaa aattcctgaa cagaacagca atggcttgct ctgtaagatc gagaattgac 19140

aaatgggacc taatgaaact ccaaagtttc tgcaaggcaa aagacaccgt caataagaca 19200

aaaagaccac caacagattg ggaaaggatc tttacctatc ctaaatcaga taggggacta 19260

atatccaaca tatataaaga actcaagaag gtggacttca gaaaatcaaa taaccccatt 19320

aaaaaatggg gctcagaact gaacaaagaa ttctcacctg aggaataccg aatggcagag 19380

aagcacctga aaaaatgctc aacatcctta atcatcaggg aaatgcaaat caaaacaacc 19440

ctgagattcc acctcacacc agtcagaatg gctaagatca aaaattcagg tgacagcaga 19500

tgctggcgtg gatgtggaga aagaggaaca ctcctccatt gttggtggga ttgcaggctt 19560

gtacaaccac tatggaaatc agtctggcgg ttcctcagaa aactggatat agtactaccg 19620

gaggatccag caatacctct cctgggcata tatccagaag atgccccaac tggtaagaag 19680

gacacatgct ccactatgtt catagcagcc ttatttataa tagccagaag ctggaaggaa 19740

cccagatgcc cctcaacaga ggaatggata cagaaaatgt ggtacatcta cacaatggag 19800

tactactcag ctattaaaaa taatgaattt atgaaattcc tagccaaatg gatggacctg 19860

gagggcatca tcctgagtga ggtaacacat tcacaaagga actcacacaa tatgtactca 19920

ctgataagtg gatattagcc caaaacctaa gatacccaag atataagata caatttccta 19980

aacacatgaa actcaagaaa aatgaagact gaagtgtgaa cactatgccc ctccttagaa 20040

gtgggaacaa aacacccttg gaaggagtta cagagacaaa gtttggagct gagatgaaag 20100

gatggaccat gtagacacta gcatatccgg ggatccatcc cataatcagc ttccaaatgc 20160

tgacaccatt gcatacacta gcaagattat gctgaaagga ccctgatata gctgtctctt 20220

gtcagagtat gcctgggcct agcaaacata gaagtggatg ctcacagtcg gctattggat 20280

ggatcacatg gcccccaatg aaggagctag agaaagtacc aaagaagcta aagggatctg 20340

caaccctata tgtggaacaa cattatgaac taaccagtac cccggagctc ttgactctag 20400

ctgcatatgc atcaaaagat ggcctagtcg gccatcactg gaaagagagg cccattggac 20460

acgcaaactt tatatgcccc agtacagggg aacgccaggg ccataaaagg ggagtgggtg 20520

ggtaggggag agggggtggg tggctatggg ggacttttgg tatagcattg caaatgtaaa 20580

tgagcgaaat atctaataaa aaatggaaaa aaaaaaagaa agataagatt gcactaaaga 20640

tcattgtgac ttcaatgaat gttggccacc atgtgcaaaa tgggtttaga tgattttaac 20700

taacctaact ggaagtataa atcaaaaaag ttaatgctga aaaaatttac tcataataaa 20760

cgttatttga ggtttagcag cagggaagtt agcatggatt ctgtgtgaag agaaaagaat 20820

gatattgttt attttctgta caataacttg ttctcagtta ataataaatt agagattata 20880

catcaagaag aattctagaa acatgtcatt gaataataca tgtgaaaatg aatctgtttc 20940

ccattttata aatataatta gaatctatat gaaggcttta atatcccatt ccttgcttct 21000

ttcaaagtgt tcattattta agatggcact attgaaatct gagtagaaaa aaatggcata 21060

aaatatatca ttacaaccca gtaacaacaa agacacatat gaattataga tttcatatat 21120

aactgatttt gtattcctca gatctatatc tgatatgtaa atacaattat ctgcttgtac 21180

atttactgtg caggtctata tgcccatccc cacctagaat cactgatgtc tatataaatt 21240

tttgctgaat aaatataagt tgaattaaca gaagtcaaat tatgcattag acaatggtag 21300

attcagtggg gtatagtagc acatgccttt aatctcagca cacatgaggc agaggctggt 21360

gtctctgtgt ttgaagccgg cttggtctac agagttccag gatagccagg tctgttaaac 21420

agataaacca tgtcatagaa aaaaagaaag aatgaaagag caaaggaagg aaggagagaa 21480

ggaaggaagg aaggaaggaa ggaaggaagg aaggaaggaa ggaaggaagg aaggaaggaa 21540

ggaaggagaa gaaggaagga aggaaggaag gaaggaagga aggaaggaag gaaggaagga 21600

aggaaggaag gagaaaaaca aacaaataat gatgaattca gtgacctaga aacagaagtg 21660

tttatagaag atagttagat agatagatag atagatagat agatagatag atagatagat 21720

agatagatag atatagatgc tttaaaaaaa agactacaca tatcaaagta atctgcagct 21780

actaccaggt aaagtatatt gatatcgttg cttgaaccat tgcacataaa caatcctcag 21840

tgacaaagtc aactgttgtg gtttctatgg cacagtgagt cagtgtccag tgatctgaga 21900

aggaagatgt tcgttatgcc catcattaca ctattcaggt cacacaggac catgataagg 21960

gatatacata tctgtctctt tttgttttag ggtagatgaa gaatgtgaaa agtttgaagc 22020

taacgcacag acctaccaat cagatgggtt tacttttacc tgtgagtata tgtgatcttt 22080

ctggaatatt taaattcctt gttactggta tcatcccata gcctgagcct ggaagaattt 22140

cttcttgcag ctttccacca ggccttacac ctctcactgg gtctgtgaag aagtcaggat 22200

ctcatcacac atgttacatt aaattgccaa aataaatgaa caaaactctc aggtcttatt 22260

gtgagatgtt cacatataaa acaactgaga atatatttta tgtagagtaa tttaagtctc 22320

acttacataa taattattgc gactattcaa taaatagtca agttggtcaa taaaaaataa 22380

atatgtaggg caagagtgat ggtcagcagt taagggaggt tgctgctctt ccaaaatttc 22440

cctattctgg tcacagtagt cacatttgat ggtgcacaac attctgtaac tctggttttt 22500

ggagatccaa tgttttctac tggactcgaa gaacaccctg gtcacatgca aaagaaaaac 22560

aaaaacaaga caaaaaacac cacaagtgca cctttacaca tagatgaaaa taaaatcaat 22620

ttttaaaaaa gataaaatat tcaagtgttt ggaaagacat ttgataaaaa gagtttggca 22680

agtacattat aattagcaga catcagaagt taataatggc agtgattaaa atgacagatt 22740

gaaatattca taccaaagtg tacttaattt aaaattcaat cccaatgaga agaaaactgt 22800

ataggttttt gtttgtaata attggcaata atttgcagta atcagttttc taaaatggaa 22860

tgaccaagtg cttaagtaac ttactttgta gaaaagtgta caatatatta ttctcatctc 22920

agtttgaaaa atatctattt ttaacttaaa tgcaactgag gggattatta atgaatcagt 22980

gacactgaag aaggaagggg acgcatttct ggggtccttg aattgagcct gctaaaatga 23040

aatggaatag tgttaaaatg tttgaattct gacatctacc tttttacact acagatccag 23100

gtgagtgtta ctttaggatt tcatatatat caagtgcaag tatgatactt attagttact 23160

gtttgaagga tggtttgcat tggaaatccg cactcatttt gcttggtaag tatcatgact 23220

ccttcttatt atgatgacga ttattattat tactctttct tatgcctgca tatgggtctg 23280

cataccacat gtgtgcttgg tgtacacaga caccagaaga gagcatcaga taccctgcaa 23340

ctggaatgac aaatggttgt gagccaccac gtgagtgatg ggaattgagc ccagtttccc 23400

tgaagagcag ccagtgctct taacctcagg accatttttc cagccccacc tagatctttt 23460

tctataatac agaacatggc tacattatgt ctgcttttga tttaaaagaa aaatttatgc 23520

ataggttgtt tatataaaat gtatttattc atagatgtgt ctacatagga gattcaatat 23580

tccccttgac tgaatcaagg atgcaaaaac attttatcaa aaataaagat ttatgtccac 23640

cagggacttc catcagaaag atttccttaa attggacaca tacaacgtgg tgatacaaga 23700

cattccatgg tgcccttatt gaagtatcag agttcactca ttggtagatg gcttagggaa 23760

cctcataatc caaaaataaa aattttagtt tagatgcttt aaaggaaaat catgttaggt 23820

ataagaaata tgaaggggga ggattttttt attgtcttgt ttctggaaag ttgacattat 23880

ttactccccc ctcattccat caggggtctg gagtaggcag gaatggatat gatgataata 23940

atataggttg agtaggaaga aaaagtcatt attttggaaa ccttctgaaa tcttaaatgc 24000

aactaacttg aattccaaag tggttatgtt tagagaatac tactacccag ggagctatta 24060

gaggaggaca gggaatgtgc tcaagtcaca ggagcatatc ctatgtgctt agaatgtatt 24120

caattgtgaa ctcaataggt ttacaactgt gaatgatgtt tttgtgaact caataggttt 24180

acaactgtga atgatgaaat gatgttccat gtttttagtc cttgtcaagt caccatgaaa 24240

gacagaggtg ggagtgagga gaggattgga cacacagtaa gataacatgg aggatacatt 24300

ctactctgaa gaacattcca catgattctc ttcatttttt ccacacaatg aagggaaagg 24360

aaatggtgtg agtgaaattt acagatgagt gtactaggag gatacttcca aaggagaatg 24420

taagatatgt gcttgagaaa ggtaataagg caatgaccat agaggatacc ctagatgtcc 24480

cctgagactt tatatgaaat aaaaaattta aaaccatatt atatttgatt caaatttact 24540

actcaacaat ttttgaagtt ataatcctta aaacaatgtt gtttcccacc ctgttttgca 24600

gatatttgtc ctaaataagg acatgcatac cttgggtgag tagaaacata atgacagatc 24660

ccattcttac taaaaatcaa tgctttttta tttttatcgc ttcttggcct tttggctgag 24720

atcaagtgta ttttttattt gttactttta tgaaaaaaaa aatcgatggg tggatgtgat 24780

gtgggtgcag tgctgttgga aaacagaaga tggcaccaga tcccacagac tcacatggag 24840

ctgagacata agtcttgtgc aagatcagag atgactcttt tttttttctt tccatttttt 24900

attaggtatt tagctcattt acatttccaa tgctatacca aaagtccccc atacccaccc 24960

acccccactc ccctacccgc ccactccccc tttttggccc tggcgttccc ctgttctggg 25020

gcatataaag tttgtgtgtc caatgggcat ctctttccag tgatggccga ctaggccatc 25080

ttttgataca tatgcagcta gagtcaagag ctccggggta ctggttagtt cataatgttg 25140

atccacctat agggttgcag atccctttag ctccttgggt actttctcta gctcctccat 25200

tgggagccct gtgatccatc cattagctga ctgtgggcat ccacttctgt gtttgctagg 25260

ccccggcata gtctcacaag agacagctac atctgggtcc tttcgataaa atcttgctag 25320

tgtatgcaat ggtgtcagcg tttggatgct gattatgggg tggatccctg gataaggcag 25380

tctctacatg gtccatcctt tcatctcagc tccaaacttt gtctctgtaa ctccttccaa 25440

gggtgttttg ttcccatttc taaggagggg catagtgtcc acacttcagt cttcattctt 25500

cttgagtttc atgtgtttag gaaattgtat cttatatctt gggtatccta ggttttgggc 25560

taatatccac ttatcagtga gtacatattg tgtgagttcc tttgtgaatg tgttacctca 25620

ctcaggatga tgccctccag gtccatccat ttggctagga atttcataaa ttcattcttt 25680

ttaatagctg agtagtactc cattgtgtag atgtaccaca ttttctgtat ccattcctct 25740

gttgaggggc atctgggttc tttccagctt ctggctatta taaataaggc tgctatgaac 25800

atagtggagc atgtgtcctt cttaccggtt gggacatctt ctggatatat gcccaggaga 25860

ggtattgctg gatcctccag tagtactatg tccaattttc tgaggaatcg ccagacggat 25920

ttccagagtg gttgtacaag cctgcaatcc caccaacaat ggaggagtgt tcctctttct 25980

ccacatcctc gccagcatct gctgtcacct gaatttttga tcttagacat tctgactggt 26040

gtgaggtgga atctcagggt tgttttgatt tgcatttccc tgatgattaa ggatgttgaa 26100

cattttttca ggtgcttctc tgccattcgg tattcctcag gtgagaattc tttgttcagt 26160

tctgagcccc attttttaat ggggttattt gattttctga agtctacctt cttgagttct 26220

ttatatatgt tggatattag tcccctatct gatttaggat aggtaaagat cctttcccaa 26280

tctgttggtg gtctctttgt cttattgacg gtgtcttttg ccttgcagaa actttggagt 26340

ttcattaggt cccatttgtc aattctcgat cttacagcac aagccattgc tgttctgttc 26400

aggaattttt cccctgtgcc catatcttca aggcttttcc ccactttctc ctctataagt 26460

ttcagtgtct ctggttttat gtgaagttct ttgatccatt tagatttgac cttagtacaa 26520

ggagataagt atggatcgat tcgcattctt cgactcttat ccattgagtc tatcagccat 26580

catactatcc ttctctactt aatttgctcc cttgagatct caagataaag agtcaatatt 26640

ttaattttgg aaacaaagaa atccgtgaga tatgaaataa tgaagtttag cgtgaattct 26700

gggcagccaa atagtttgca gcttttggtg atgcacatat ttatgcattt ttctctgtgg 26760

tataaatctc agtatttacc ttggatatat gaaatctcag gatttgttca gaggtttaca 26820

aaattaatat aattttatga aattcttcaa aataatatcc atacatggca tccatgtaca 26880

cagatggaat cccatgaagc aactttgtca tggacaaagg tccactttgt aatggatagg 26940

gtctactaag atccaacaca actcagacac tgaatcaata cagaaaacaa aaatttattg 27000

taatcaaact gctactgatc aatcagcaac attgaacaga cttgggagct gaactatagt 27060

ccccagccaa aatgtttaca gggctttagg cctgaaagac acaaatatct atgtcaagtc 27120

acagttaaat ttttccatca attgagattc aggtataggg gacttttcta gaaacatttc 27180

tttgtggtac atttatcctg tcctcattgg ttagtttact taactgtggc agagtgactt 27240

gcccagcatt catgtctcaa cttgtcaacc aaggtgtcgg tcaccctggg agatcttaga 27300

aacttaaact ttgtttgaac cctattcaaa atggaagatt tattcaaaat ggctctttat 27360

tacaaatttc cctctgatac attgctcatc aaaggaatca attataaagt tatttaatgg 27420

catataatat ttatatatag aactgagttt cataatgaca ttctttatac atgtatatca 27480

tacattttaa tcatatttcc cccctttatc tacctcttat tctaacctgt tgctttcctc 27540

atcccaacag ccgagtcttc attctacttt cacacacaca cacacacaca cacacacaca 27600

catatatgtg tgtgtatgtg tgtatgcata tatgtattgt atataaattt tattatagag 27660

tatagagcat attatatatt acattcacta tattatacat tgtcttgtgc attatattat 27720

atatatatga actttctggt gacacaatca atttaattag gactgcttgc ataagcatgt 27780

gtacagactt atttacagga gcatggacac aacatcagca tctagatcac taaaaatcat 27840

ctcaggctcc ccctaacaac catgacttgc ctgtaaagtc tcagaaatgt ttggggcctt 27900

gtgagtgagt ctcctgaacc acccagcaac ttttattatc tataatccct cagaagaagg 27960

gggaccacat gaaccctgcc aattccacca atttggttca ggtcttcctt cattgaaaac 28020

ttaaggacat tatgctacta agaagaactc aactaaatta aacattttca ttctcatctc 28080

cacagatatt ataaagaata tttgaaattg taacttctca atggcaattg attcatctct 28140

gtgaagtcta attattctgc tccccatcct atgaagacct aagtcccaat ttattgcttc 28200

ttttctttcc tgcatttatc ccttgtatga cgttactaac ttactgatta aattgatact 28260

gtatgcatac acacatatca gaagcatgct cttaaagttt ccaatgctta aaaatgtttc 28320

actatgcaca actcttaaaa aatatactca tctattatca agcaggataa atgtacttaa 28380

aagaatagtt aaagagttgt acagatgtct tagtcggtgc tcactaaaac ctgtctattg 28440

cctctagctt ctggggtagg atgtgtctca tgagcactcc cctacctagc tataattgca 28500

tggtcaggcc tcgcacacat aaccacatct gctttgagtt catgagcaca catcaccaca 28560

tctgctttga attcatatca atgggcactg cagaaattaa aaaaaaaaaa ccattaggtc 28620

ttacttcaaa agcctgtact tcacaaaatt ggaaaatcta aatgaaatgg atgattttct 28680

atatacatac cacttaccaa agttaaatca aggtcaggta aacaacttaa aaagtcctat 28740

aactcctaag taaatagaca aagtcattaa aatattccca accaaaaaaa caaaaagccc 28800

agggccagat tgttttagtg cagaattcta ccagactttc aaacaagagc taataccaat 28860

atgcctcaaa ctattccaca aaaataggaa cataaggaac actacctaat tcattgtatg 28920

aggccaaaat caccctgata cctaaaccac acaaagactc aacaaacaaa agactctcag 28980

accaatttcc cttatgaaca ttgatgcaaa aacactcaat aaaatattag caaactgaat 29040

cagagaaagc atcaaaaaca tcattcaaca tgatcaagta acattcattc aaagggttgt 29100

agggattttt caatgtatga aaataaatca acataattca caatataaac aaactaaaaa 29160

aaaaaactaa tcatctcatt atgtactaaa aaaggctttg acaaaatcca atctctttca 29220

tgttaaaagc cttggagaga tcaggatacg agcacatatc taaatacaat aaaagcaatg 29280

tacagcaagc caatagtcaa agtcaaatag agaaaaactt aaagcaattt tactaaaatc 29340

agggacaaga cacagctgac cactctctcc acatatattc aacattgtac ttgaacttct 29400

agctagagaa ataggaaaat taaaacagat caaggggata caaattggaa aggaagaagt 29460

caaagtatca ctctttacag atggtgtgat agtactcata agtgaaccca agaattatac 29520

cagagaactc ctacatctga taaacacttt cagcaaagcg gctggataca aaattaactc 29580

aaagaaatcg gtagccctct tttatacaaa ttataagtgg gtcgagaaag aagttaggaa 29640

gaaaatacct ttcacaatag ccacaaataa tataaaatag ctaatagtaa ttctaaccaa 29700

gcaggtgaaa gatctgtatg acaagaattt caagtatctg aaaaagaaat taaagaagat 29760

atcagaagct agatcccaca tgcttatgga tcaattgaac taacaatgtg aaaattgcat 29820

ctctccctgc ccttatggat catcagacaa tactggtcca tgtggtcaaa gggaacagag 29880

atgagagacg agaggttaac atgccctgtg agtacataca gtaaataaga tacatcagaa 29940

ccagatgcag ggaggcagac aaactttacc tggggtgatt caagaactat ataatttggg 30000

gatgctagaa aaatccaaga tggccagagg tcattgactg aagacttagg gtactgaaat 30060

aattcactag catgggaaag tatttcacga atctcagatg ctagctgaat gagttcttat 30120

caagagaaat aaagggatat ggactccaca ggaaaaccaa cagagtcaac tgacacagac 30180

ccttgagggc tcccagagac tgaactacca accaaagagt aagcatgagc tgtacctatg 30240

accctacaca catatgtagc agatgttcaa catggtcttt atgtaggtct cccaacaact 30300

agagtgggga ttgtccttga ttctgttgcc tgcttgtgga tcctgtttcc ctgagtaggc 30360

caccttgtct gtcctcagtg ggagaggatc cacctagtcc tgcagtaact tgatgtacca 30420

gagtaaggtg atacccaaag aacacacacc ccttctcaga ggagaaacgg aaggggaggg 30480

gagctgtgtg agggtgagac taggaagaga gagaggctga gattgggata taaagtgaat 30540

aaataaatta acagaaaaat aaattggaga ggaaaaagtc aaagtattgc tagatggttg 30600

gatagtatgc ataatctcta caaaaattct accagggaac tcctacagtt gataaacatc 30660

cttcagcaat gtagctggat acaaaattaa ctaaaaaaaa tcagtatctt ttctttatac 30720

aaatttgaaa tgggctgaga aagaattggg gagacaatac actttacaat agccacaact 30780

aatataagat aacttggtgt aattctaacc aagcaagtgg aagaccccta tgacaagaac 30840

ttcaagtctc tgaagaaggg aaatgtggta catttattaa atgggatact cctccagaag 30900

gggaaataac atagacttgg gaaatgtttt ggaatagtag gacataggac tgagtgagcc 30960

agaggggtca aggacaccac aataagactc acacggtcaa ctaactcggg cctatggtag 31020

ctcacagaga ctaaatcacc aaccaaagag catgcatatg ctggaagtag gcccccctac 31080

acatttggag cagatgtata gcttggtctt catgtaggtc ccctaggaat tggagcaagg 31140

attgtctttg actctgttgc ctgcctttga aaccgctcct cttggctggc cttccttgaa 31200

gggctacact gggaatggat gcactaagta cttctgcaac ttgaagcacc aggactggtt 31260

gaggagaaag gatgaggtaa tgggggaagg ggtttgtgag ggtagtacta ggagaagggg 31320

aggttgtaat tggggtgtaa agtaaataaa tagatagata gatgatagat agatgataga 31380

tagatagata gatagataga tagatgatag ataggtagat agatagatag atagatagat 31440

agatagatag atagatagat agatataaga aagaaaattc aaatactaga atccatattg 31500

tgatctaacc atgtaaaatt ctttcttcct acttgatatt ataaggtatt ctttacccaa 31560

agaaaaatat tatttcaagt ctggtttcta ataccatgaa atataaaatg tgattgcagc 31620

attgggaagg taaatcaaat ttcatacagg agaagacatt tttcctgtct gatacttgaa 31680

atagtgtttt catgatattt ttcatgaatt tcactgctgc aaagatatat ttactcttgt 31740

gtttttaaac attatcataa tgaataaagg accttggttt tcaaggcata tacacctcct 31800

tcatggagta tataccactg caatccttag gcatttcaca caatgtaaca aatacaatat 31860

tggcccttaa ttaactacac aagcatgaag catcagggat gaattaatct caaatacaca 31920

cccagtatcc catcaaaatt atttggacaa taacacatca aacttatttc cctaaaggtt 31980

tacttttttt ctaactccat aagctcatcc atcagtcatt gttttaatat acccgatatt 32040

aagtcaatat cttaaatgta atgagatata aatttttttt ctgacaaaca agaagggaag 32100

gattatggat ttctattttg ttgctcataa ggaaacatgg gtgacataat gtgctagttg 32160

agccattcaa acaacatgga cttcagattt tgattttcgc actgagtgga tgatacaaca 32220

agaggtaaaa ttggaagatg cactacctaa aacaaagaga tacaaaccaa atctttaatg 32280

gtttttagac acatctttga ccatgaaaat atggcaaagg aaagttgtct ttaaatgtct 32340

tcattattat ctgaactcaa aaattaattc acatcacagt gttcacactg tgaacactaa 32400

gtcacacata gtctcatctt gtcttcagga gacttttctg ggaattatca ttattttgat 32460

aggggaattt agaagagata gttgggtttt acaaagtgac agacaactga ccaacagatt 32520

ctctatgctg ggttccaaat gacacttctt ccatttcttg ccatcaaatg cagtaagtga 32580

aactaatccc actaaagaaa tgtaaagact atgtaaattg aacaagaaat aaaaaactcc 32640

cataaaatta ttataaatat ctataaagta agtaatagca ttctttttgt ataaaataag 32700

ctgagaccag agaggtttat agattcttga ttccaacacc tgatttacaa aaaactgcat 32760

atatatatgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtatacat atatatatat 32820

atacatatac atatatatat acatatatat ataaaacaaa atcccttaaa gcattgatga 32880

acttcaataa ccttttctct atttgtacat tttaattttt ctcttatttt ttaaaagtag 32940

aacataattt cttttttctt tagttttaag aatggtgaca ataaattaca taataataaa 33000

gagataagaa agaaaacaca tcagtcagca caatttgagt ttgcttacta agactgtttc 33060

tctcaacaga tgcagagtcc catagcaaaa ccttaggcag agcttgggga gtcctgcaga 33120

ggatggggag gaaggatcac ctaaccagag gagtcaggga caccaaaagg acaaggctca 33180

cagaatgaac tgacatggag gctgtcagag atcagggagc cagtaggggt ctaataggcc 33240

ttgggtgtat atgttatggc tgagtgtagc ttatgttctt ctagggttcc taacaatgga 33300

agtaggacct atctctgact cttttgcctt cttatgggat cctttcactc cttttgggtt 33360

gcctagcaga gccttgacgt gatggtatat gcctgatctt attgtaactt gttataccgt 33420

gtttggttta aattgctggg aggcctgctg tttttggaga ggacatggaa gggatggata 33480

tatgaaagag gggaggtaag agagacacag agggaagggg aggaaggaga aactgcagct 33540

aggatgtaat atataacaga agagttaatt aattaattaa attttaaaaa agcctgtggt 33600

ggttttaata agctcagccc aggcagtggc actattagga ggtgtggcct tgttggtgta 33660

ggtgaggctt ccttggaagt agtgtgtcac tgtgggggtg agctttgaga ctcttctcct 33720

agctgcttga aaacagtctg ctcctggatt cctttcaatg aggatttagg gctctcagct 33780

cctccagcac catgtcttcc tggatgctgc catgcttccc acctggatga taatggactg 33840

aatctctgaa cctgtaagcc agccccaaat aaatattgtg cttcctaaaa tttgacttgg 33900

tcatcatgtc tcttcatagc aatggaaacc ctaactaaaa cagagcctct ctggctctta 33960

agccatgctg gctataaagc ctcacatatt acatgacata ttattataga aactttgtat 34020

cacaccctga atatcatatt tacaatattg taggtaatat tttcctctct aattatgaca 34080

tgtaaatgaa ttacgtaatt atactcaaaa gaatttcttc tgacattatt gactacctta 34140

ggttttgttg catttttatg tgtttattat tttatttgtt ttgttttgaa acacattcaa 34200

actatgttag caacggttat cctcaaactc aatatataga tcaggggggc ctcaaactca 34260

cagaaaacaa tatgactctg cttcccaaga cacagaatta acagtatgga tcaccatgct 34320

caattaatca caggttaatg tattttagtt tttaattatg tagatattca ggtatctgca 34380

tatgagcaat gttaccaggt gagttcagta cctgacgagg gcagaagagg gagcagattc 34440

ctctggacct aaaattacac atgattgtgc attgcaatat agttgctagg aactgaaccc 34500

aggtcgaaag gaaagctagg actctgaccc agtgagtcat cctaagccag attatttttt 34560

aataggtaca gtgcacattt tctttgttgt gtatgatggc tagaatatgc ttgccctatg 34620

gaaattggca gtatgaggag gtgtgtcaat gttggggtag gtgtgacctt gttggaacat 34680

gtgtgacact gtgtgagtgg gttttgaggc tcctatgccc aagctctgcc aaatgaggaa 34740

gagagcctcc tgctggctgc ctgcagaaga aagactctcc tggctgcctt tggatcatga 34800

tgtagaactc tcagctcctt ccccagcacc atgtctgcct gcagactgct atgcttcctg 34860

ccatgatgat aatcatgaac ctctgaacct gtaaggtggc cacaatgaaa tgtttgcctt 34920

taatagagtt gccttggtca tggtgtctct tcacaaatat atacccccta attcagacat 34980

tgtgtattac atcacattga ttgaagacag aatgtgtaca tgaaaaatca atttatttta 35040

tcaacaaaag aatcagtacc atggtaggag tatgggaaac aaatccatga agcagagatt 35100

ctggcttcat aggaaagatg aaaagaaaaa ctaagaaaag gatgagctct cttcattgtc 35160

atgattctga tttcatgaaa gaggtgatgt gggaaatact tctgatcttg ctgtcatctg 35220

tgaagcttca aaagtaaaaa acaagacaaa caaatgaaac agtaagatgt gcatgagctg 35280

gtgcttctga catgagcttt ctgagattgt aaatgaaaaa caaaaattaa tcgacacgga 35340

atatggtgaa aggtttgatt ttaaaaatga cacatgtcac agggttagac ctaggtttgt 35400

tcttggttga cttccataac tctcttccgg catttaaact gagagttttt ggtctaaatg 35460

taatctacca taacacctat gtgcaaggtt gtgtctaagg agactttaca aagttcatgt 35520

acatttacag tatttccaca ttcatgctac actcttggct gtcacaaata tcacttattt 35580

tcaatagtca agtttcatta aattcttacc tattaccttt aagataaaag aaatcaacac 35640

tttggtatag gagagttgct tattcccatg ttataaatat taacagcaac ataaacgata 35700

gctttgccac cttggattat atatgtaatt agaattataa agagatttcc tctactaaag 35760

gcataactaa tagactaaag aatgaatttt tagcagatta aaatattaac aggctctgct 35820

gccctgttgt actcacccat attgtgtctt tattggttac aagtgtctgt gagagacaga 35880

aaggaaggaa ataaccacaa acaaaagaca tagttagagc tccttaatat ctccagtgac 35940

tttaaataat tttaaaaatc tgatttagac gactgaaatg atgattatcc tggatatctt 36000

caggtgcatt agtttgctgt gtgaagcaca atgttgttac ctgtgggcgc caagtgctgg 36060

atattctcct ttggaatatt gtattccttg accagcttcc caagctcctg cttctgtgct 36120

ttgctcaggg tctctccttt tcctacatca cataaagcag aaaggaagaa aaagtgtagc 36180

ttacagtact gggtggctca gaacagatgg agttataatg ggttgtgtga tattgatgca 36240

tggaaacatc ttactttgtg ggccctccct caccccatca gtctcattct gatcaaccta 36300

agatctctaa agtaaaaaga acacatttaa tgaagctgaa ctatgatagt ccacacccta 36360

atgaataata tcgttatttg tggtggaatt gttattgttg ttattgccat catcactatt 36420

aatactccta ctactactat tataattatt cgtactttcc atatgaccgt atatttattt 36480

ccaaaaaggc ctgtacataa tcctggtgtt tgaaatactt gaactaaatg tttgtccatg 36540

ctgacttcta ccttacttct gtgtagattc tggagtccgt gccttggata attgataatt 36600

atcaaaataa gcagtgaaat caggctgaac aggctcatga acctgaatca attacgactc 36660

caacaccacc ccacctcacc acttacccaa cctcactacc agattccagt acccagtacc 36720

cagcctccag tcccctgcct ccaggcccaa gcccccaaat tgcctctgct tcctccattg 36780

cccctcacaa ctttggtaaa caaagcaaga ttgttgggtt tatatatata tatatatata 36840

tatatatata tatatatata tatattatca tgacacaaag caaggtcatc tggaaagagg 36900

taacctcaat taagaaagtg ctaccctcag actgctctgt gagaaacctt gtagactcat 36960

tttctagatt gacagttgat atggaagtgt ccaccccact gtaggaaact cagcagcaca 37020

gttttctttg ttagtgtttg atggtagggt gcctagacta tgggtagtgc cacctctggg 37080

gagatggtcc tgggtgctaa gagaaagcat gctgaacaag acctggggag caagccagta 37140

agcagcactc ctccatgccc tgtgcatcag ttcctgcctt caagttcttg gctgtttggt 37200

acagagacag atgggtcaat aattggaata ggattgaaga ccccaaaata cccccaacac 37260

acacacacat ggacacttga ttgttgacta agaagacact accatatagt agaaaaaaga 37320

gagcatcttc agcaaatcgt gctggcctac ctggtggtct gtatgaagaa gaatacaaat 37380

tgatacatat ttctcaccct gtacaaagca caagtccagg tggatcaaaa tcctccacat 37440

aaaatcatat atactgaatc taatagaaga aaaagtagga aatagcttgg aaggtattgg 37500

cacaggaaaa aattttctga accaatggct cagctctaag atcaacaatt gacaagtgga 37560

acctcataaa actgaaaagt gtcttcaaga caaaggacac tgttagtagg aaaaacagca 37620

acctacagat tgggaaagaa tcttcacaaa ccacacatcc aatagagggc taatatccaa 37680

aacatacaaa gaactcatat attagactcc agaaaaccag acaacctagc caaaaactgg 37740

ggtacaaact aagcaaataa ttcttaacta cggagacttg aatggctgag aagcaatgac 37800

ttctttttga aaatgaactg tgttatagga gcttaagcca aatcaaccct ttcttcccca 37860

agttgctttt ggtcatggtg cttatcatat cgatagaaac cctacaagag ggaccactct 37920

caccagcaac taaaatcaca tttgtctcct gtccgctctc atccacatta acgttgtgaa 37980

agaaaagggc gccatcttcc ttcattacaa cttcgaagta atttctacca gagtctgcaa 38040

ttaaaagaga atcagcttag aaatcagtag aatcattgga ggtttcacta ttattttaca 38100

tatgaaatct atgatatttt tatttctttt tcaattattt gacaaatgtc atttacaatg 38160

gtttaaaatt gtaaatgaga attactaagt ggtagagaca ctcttgcatt aattaaaata 38220

tttttttgaa tttaaaaaga atgtccataa ttagacggga atgctggcac acgcctttga 38280

tcccagcact tgggaggcag aggcaggtag atttctgagt tcaaggccag cctggtctac 38340

aaagtgggtt ttaggacagc cagggttata tagagaaacc ctgtctcaaa aaatgaaaaa 38400

aaaagttcat aattacctta tgtctccaca gcctatttaa aaagtgaaca caacgctaat 38460

attaaaatac cacactgaag cagggatggt gactcaaaca tcaaatccca gcaatcagga 38520

ggatctctgg ggctagcctt gtcgcagaac tagttatagg acagccaggg ctatgcagag 38580

taactctgta tcaaaaaaaa ttttaaaaac aaccacaaat gtgtctatgt atgtctgtgt 38640

gtgtgtgtgt gtgtgtgtgt gtgtagcaaa tgtatagttt tccatatatt aaacccttaa 38700

gaaatcagtc ctgtagcttt atgggactgc cttctaaatg tcatttatac ttaaataata 38760

ggcacaaaaa tgtctctaat aatacttttg tatgaatgtg tataatacac cttaactgat 38820

aacataaatg tctggaagtt tagttaggat tttggaagtt gcatcaaaaa ttatcagatg 38880

aaattgttca aggatcctgg ccctttagtt gtgcggcctt gtcaaacctt gcaaaatttc 38940

tctctgtctc tctgtctttc tgtccctccc cccctctctc aattagatta tgcatcccat 39000

taattgatta catactcaca gtcagtagtg taccgcccat cttcttgttt ttctcccaca 39060

acagtgtgtg tctgacactt gccattcatc cttcagaaat aaaaatcaaa aacttgcttc 39120

tgaatttact ctttcaggtt gctcatattt ccttattgtg tggtagtatt aactgtcttt 39180

gggaagtgtt taatttgttt aaataaaccc acatctgaag actgacacca acactctggg 39240

gttatgattg acatggaaag taaatccagg cttccagggg aagacactgt cctcattttc 39300

tacccacatt tcctgttcat gactagtttc aaccagaatt acccaaccct gtaaaactgt 39360

agaacacatt gcattcagtg ttccttaaat caaggacaca actcagaata aatatgccca 39420

ggagatcaat tccatttttt cacatggccc aagtgtcagt gaaaatttca cagacattca 39480

tgtgcccagt ttctcagtcc tgtccatgtg catcaggtga atgtcactta ctggacatgg 39540

aatttgattt tgagtgtccc acagtcgtca ttgcactcca tatgctcaaa gtacgctctc 39600

aggtctccat tcatctttac tttctccacc ttgtccgcag ctatgtaaag ggtgcgccag 39660

tccccattaa cctaaatagg acagacacca ttgcaaaagt tggttagtca atctgttccc 39720

ttttattcag caacatttgt cctaattact acatgacaac aattccataa gtcaacaaat 39780

gaacttggac caagtaaaat gcagatgtct ctctgctaga gagtagatta ggagattgtg 39840

tcatcactca ttcacactag aatatggaac acaggataca gttcacactt tgtcaatcaa 39900

taacaatgca aagtccaatc tgtaattttc tcttcttaac cttctttcat actagacaga 39960

agtcattgaa aacatgcaaa gagttgaaaa tacactagga ctgcattaca gataggattc 40020

agataatgta tatatgctat atataccaca tataatatgt aatgccatac catttatagt 40080

atatgatata tatgctcaaa ccaactacag agtgtacata aacaccccag accctttatc 40140

cccaaatgca cacacctctg agggactgat atcaagagat tcatgatgtg cacaggatac 40200

acctaatgca agcgcaatta gcaggaactt caccatggta gagcctggat tctctccttc 40260

cgaaggagtt cagagaccaa gggcaggtga tggggagacc cagaaccatc tccaccttat 40320

atagtattga ttattggcct gagattggca tggattgcct gtggtaaaat tccagcatat 40380

cctggtggtg gaaacatctg tgatgacaat tctgtttttc tgctactttt gaaataagat 40440

taacttgagt aaagccatga aattgacctt ttagacttct gtggacttgg gctagctgtc 40500

agaaaacaca aatatccatg tccctaaagt ccaagtttct catttggaac actttaaaga 40560

aatgaactta tttgactcag gctattttaa tgatgacaaa ttttccatca atcagaccct 40620

ttgatcacag gttaccatat ggatattaac aattttttat acaattgaat atcaatggac 40680

atatatttct agaacattct agagtgttct agaatgttct acaacattct ggggcattct 40740

tgtaaaaacc tttgtgaaga agtgtactgt tttcctttct gggcaggaat ttgcaattta 40800

gattcatgat tttaaatatt tttataattt gatattttca tcaagatgtg aagattttta 40860

atgatgtaaa attcccattg ttttgtgggt acatttgttg atactatgtc ctggtaatca 40920

gcattgcttt tgctaacatt actttatata ttcaataata tatacacaca cctttgtttc 40980

tgattgctat aagtgtattt tttgacaact gtgtctctaa atcatttatg caatgaaaag 41040

tcagctgcta attttctcat gtttgtgtct gagaaattct caacgttttc tccattgaga 41100

actttgacct gtggatggat ttgcaaatat tcaccgaaat gcatgactca aaactagttg 41160

tcaatgttcc aaggctttaa ataagaaata ttcacccatc ccatgttcag aaaggttctt 41220

gatgtatgtt cttctttttt agtatacccc atacaaatgt gatccttatt atatttttac 41280

atatttttct tgattcattc cttcttctct gtgtttgatt attcaagaga taactcagtt 41340

ccactggaac aagattgggc tgacctacaa acatatttat tttcatccat tcatttcttg 41400

tgaaatctct actttccttc agaattctaa tgtgatttgg aatacagata atgttgggaa 41460

aatgtaatga aaatcaacca gaaaaagctg tcatttaata cttccaaagt ggataattac 41520

ttaagactgt atgtgcactc attaaagtcc ttctcatttc tcctccagac ccagtaacaa 41580

caacacatta atcctattta ttgagtatcc ttctggaaaa ttacctacaa ttttgcacaa 41640

actcaggttc attcttccac atttccaaca gttttattaa aatataagct ttccttcctt 41700

atttattaag tgaagtgagt ttctctccct tctacctgat tacagagaaa ggtgatacaa 41760

cacagcctaa actggagtct tggaaagata aaaacaaatt ctgcctcatg tcaaaacata 41820

catttattcc taaggaactt aaagattatc tctgtctgtt tgaactttaa tattgaagca 41880

tgtacacaaa cacacacaca catgcacaca cacatacata cacacacata cacacatgtt 41940

tcttatgttc ttgtgtattt attcataaat attttatata tggatatggg tttttatata 42000

ttttctatct gtggatatat atttatgtgt aatgtaagta tagctatatt ttacattcag 42060

atttatatat tccaatttat acatgtatga tacatatata catgtgtgat acatacatat 42120

ttgtttccat tttcagtaat ttaccaatta aattcctaat ccacacattt tgtctacctc 42180

agaaaagtga agaaagaatg gaaaatgtag gtgcttcaaa ggacagagtt aaaacataca 42240

aaatactgac acaacggatg ctgttattga agtcatggcc aagcttagaa ctctttgatg 42300

tctgaccttt gagtagaact tggctaaaag tctgtctcct ttcttcttct tttttaattg 42360

gatattttat ttatttacat ttcaaatgtt atcccctttc ctggcttcac ctctggaaaa 42420

cccctatccc atcttcctcc atctctttct gagggtgctc ctacccaccc attcccacct 42480

caccacactg acattccctg acactggagc attgagtcat ttacaactca aatgctatcc 42540

taaatgtccc ttatatcctc cccccaccca gtagccttat ttataatagc cagaacctgg 42600

aaagtgccct gatgtccaag ggcctccctg ccattgatgc caaacaaagc catcctctgc 42660

tacatatgct gctggagcca tggatccctc tatgtgtact ctgtggttgg tggtttagtc 42720

cctgggagct ctggggttac tggttatctc atattgttgt tcctcctatg gggctgttca 42780

tcccttcaac tccttcaagt accttctcta actgctgtat tgtggtcccc atgctcaatc 42840

caatggttgg ctgcaaacgt gtgcctctga atttgtaagg ctctgtcaga gcccctcagg 42900

agacaaccat atcaggctcc tgtaagcaag cacttcttgg catccccaat agggtctggg 42960

tttggtgtct gtatgtgatg gatccccagg tcgggcagtc tatggatggt ctttccttca 43020

gactctgatc cacactttgt tcccatactt cttttagaca ggttcaattc tgggttaaaa 43080

atttggatat gagtgggtga ctacgtcccc caacctgggg tcttgcttaa cttctggata 43140

tggtctctac atgttcatcc tccccttttt tgggcatttc agctaatggc atccaagttg 43200

ggacctggga gcctcttaat ttactggcat ctgggacttc ctgatggcta tccctgtttc 43260

ccatcattca ttgctacaca cctctgttca aattcctgac cctctgtaaa atcgtccctg 43320

tctcctagca cacttgttct tacaccccag tccctctcct tctcctctct tccttccaag 43380

tccctcctat cctctacctt ccaagaatat tttgttctcc cttctaagat ggtctgaagc 43440

atccatactt tagtcttctt cttgagcttc atatggtctg tgaattgtat cttgggtatt 43500

ccgagatttt gggttaatat ccacttacca ttgagtgcat actatatgtt ttcttttgtg 43560

actgggttac ctcaataagg atgatacttt tttgttccat tcatttgcct aagaatttca 43620

tgaagtcttt gtttttaata gctgagtagt tctccattgt gtaaatggac catattttct 43680

ctatttgtct gtagaaggac atcagggcac tttccaggtt ctgcctatta taaataaggc 43740

tacttggtgg ggggaggata taagggactt ttaggatagc atttgagttg taaatgaaga 43800

aaatatctaa taaaaattat tataaataaa taaataaatc tattataaat atagtggagt 43860

atgtgtcctt gttatatgtt ggagcatctt ttgggtgtat gttcaggagt ggtatagcta 43920

gatcctcatg tccaattttg tgaagaacca ccagaccagt tataccacca gattagttat 43980

acctccttat aattccacca acaacagatg agtgttcctc tttctccaca tctttgccag 44040

catctgctgc cacctgagtt cttgatctta gtcattctga ctggtctgta gtggaatctc 44100

agggttgttt tgatttgcat tttcctgata actaaagatg gtgaacattt gtttaggtgc 44160

ttcttgtcca ttcaatattc cttagttgag aattctctct tcatgtctgt actccattta 44220

aaatagggtt atttggtcct ctggagtcta actttagaat tatttgtata tttcggatat 44280

tagcactcta tcgaatgtag gattggtaaa gaacttttcc cagtctgttg gtttctattt 44340

tgtcccattg acagtctcct ttcccttaca aaagctttgt aattttagga ggtctcattt 44400

attgattgtt gtttttagat cataagccat tgctgttctg ctcaggaaat tttcccctgt 44460

gcacatgtgt ttgaggctct tacccacttt ctcttctatt agttgcatta tatatggttc 44520

tatgtggagg tccttggtcc acttggagtt gatctttgta caaggatata agaatggatg 44580

gatttgcatt cttctacata ctgactgcca gttgaaccag caccatttgt tgaaaatgct 44640

gtcttttttc cactggatgg ttttagctca ttgtcaaaga ccaggggaat ataggtgtgt 44700

tggttcactt ctgggtcttc aattctattc tattgatcta cctgccttag tctgtaccaa 44760

taacatgcag tttttatctc tattgctttg tagtacaact tgaggtcagg gatgatgatt 44820

tccactgaag ttcttttatt gttgagaata ttttttgcta tcctgggttt ttgcttattc 44880

caaataaatt tgaaaattgc tctttttaag tctatgaaga agtgtctcct tttcagtagc 44940

ctgctgacat tccctactca agaaacaaca aatgtttatt gttttttcta ttctttgatt 45000

ttgtccccca ttatatttta cacaatgttt gggtttattt gcttccctct ttgttttctt 45060

tcctttctat tgatttaata atctatggat tcttctgtgc attcagtttc gaggaaaaac 45120

agtgaggaaa tgaggcacta gaaattctga ggctttcata gtagtgaggg atggatctgc 45180

taattgtccc atttattggt ggaagatttc tgtcattctc agaatcaggg tttctgtgtt 45240

agaaatttca tggccttggg agaggtgtgg tgactaatgt aaaaactcaa ataaaatttc 45300

agttaaaacg ttaaaaagaa aagaaactat acaaccttgc ctttttcaga tcatagaggg 45360

aaaatgttca actttttctc atttaatatg tttaaggttg aaatagcata tgttaattgt 45420

attaattata catcattata gatttcattg tgataaataa taatcgggtt tatttcaaag 45480

tgcagcccta ttcactgaca cttaaacgat ttttaatatt ttagatttta atgagctaac 45540

aaattagcag tattcttgat caattttcaa acacttaatt ttgattaaca ctctcatatc 45600

ttcttgtgtg ccctccaact ccactcccca acccagctaa accattcact gtccaacact 45660

ggcatttctt tattacatca tgtttacata gtactgatac tcctttatgc tctattttat 45720

tttaagactt ttgaagatat tttattttag ttttgcaaac atatccacac actttcttcc 45780

tcctatatat gcacatatat gttgcaagct aggttttgtc tactggttgg taattttcat 45840

gattagctga tttcttaaaa ttaataatat gaactttatg tatcagttga gataattacc 45900

atgggtattg cccatagtcc tactgctttt gcacctggtt ttgtcatcaa gtggtgtgga 45960

gctgacctca accaaatcag tttagtagaa tttcttcatc tttggaatct taaaataagt 46020

taagaaaaag tatgcttgct tctttttcaa atgattgcta gggttcggta tcaaaataac 46080

ttggtcttaa atctgctttt ggaggaaaat attttattac tgactcaata aatagttaac 46140

tgaaaaatag ttaatgttgt cctgtgtaat tttatcttaa ggtgtctact gctaggatga 46200

aacaccacga ccaaatgcaa cttggggagc aaagggttta tttggcttaa aaatccacat 46260

catagcccat caattaagga agtcaggaca ggaactcaaa cagggcagga atccagaggc 46320

aggcactatt gcaaaggcca tggaggggtg ctgcttactg agtagctcag cctgttttct 46380

tatacaactc aggaccacca gcatgcggtg gctccatgaa caacaggctt tgctctcctt 46440

catttatatc taatctttaa aatgtcctat aagcttgtct acagcctaat cttatggagg 46500

cattttctca attgagatcc tttctctcag atgactttag tttgcgtcaa gtggcataaa 46560

actcaccagc acacttcatt taattcagtc ttagtgaaat gcatgttagt agcaataaat 46620

ccattttctg cagactctcg gacctgtgtc actgaagttt tcttaataaa acaaatttgt 46680

gtcagtttct gtgttgttaa tgtatgttta tctgatttcc tttcttgatt ttattaattt 46740

atttatcttt ccttctctca ggcactttct cttctctccc ttctctttac ctcatcaaac 46800

aatttcttgc tttgatcttt aaatgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgctc 46860

tttggactgt gtttttgtta tgcctgtact gaaaagaggc gtggagctca aacacgtggt 46920

taaaaataac gtggatctca atgtcagtga caggaaaaaa aaacccatat gattccaaaa 46980

accttcagtc ctcatatgtt tcatgcaaca aatttggaaa aagggtgatt tagtgacaga 47040

attcatacca actcttcaag tgagtaactg tccaaaatta gatcttgtca agtgtcaaat 47100

ttaaatattg agtcatcttt gggaaatatt gagaagtgga gtaataaagg ttttaagaaa 47160

ataagagtga acctatctgc atttcaatat gatagctact cacttctggc agagtgagaa 47220

taaattttaa agggtatggc ctttagtagg tcacacacct gtaagtatgt actgtacaca 47280

aatacaactc caagcataat ttaaaatttt tttttaaaaa aatgagaaag tggaggaata 47340

aaaaaacagc tggaaggaat tagcgggaga aatggggatc aatattatca aaattcattt 47400

tgtatatgta tgaaattttc aaacacttaa taagattatt atatgcatta aaataacttt 47460

aagcatgttc agtgtggata agtcaatatg taaatgaggg actgaaaaag taacagaaaa 47520

caaaaattct gcatagaaat acttaatatc tggaaagaac acagatgtcc ctcaacagag 47580

gaatggatac agaaaatgta gtacatttac acaatggagt agtactcagc tattaaaaac 47640

aatgaattta tgaaattctt aggcaaatag atgtatctga aggatatcat cctgagtgag 47700

gtaacccaat cacaaaagaa gtcacttgat atgcactcac tgataagtgg atattagccc 47760

agaaacctag aatacccaag atgcaacttc caaaacacaa gaaaatctag aaggaagacc 47820

aactcatgga tacttcattc ctccctagaa tagggaataa aatatccatg aaaggacttg 47880

cagagacaaa gtttgaagct gagacaaaag gatggaccat ccagagactg ccccacccgg 47940

ggattaatcc cataatcagc caccaaatgc agacactatt gcatatgcca gcaagatttt 48000

gctgaaagga ccctgatata gctgtctcct gtgaggattt gccagtgcct ggcaaataca 48060

gaagtggatg ttcacagtca tttatagcac ggaacacagg gctcccaatg gaggagctac 48120

agaaagtacc caaggagcta aagggatctg caaccctata ggtggaacaa cattatgaac 48180

taaccagtac cccggagctc ttgtgtctag ctgcatatgt agcagaagat ggtctaattg 48240

gccatcactg ggaagagagg ccccttggtc tagcaaactt tatatgcccc agtacagggg 48300

aaagccaggg ccaagaagtg ggagtgagtg ggtagaggag cagggcgggg ggagggtata 48360

ggggactttt gggagagcat ttgaaatgta aatgaagaaa atatctaatt aaaatttttt 48420

taaaagaaag gcttcatata gactctgctc ttctatttac taaatactca aatagcccac 48480

tttacataag ctttatttaa aaccaaaacc agtcatcaaa cacaagatca aacacactct 48540

atccttgtct gtggaaaatg aagattgtca cctgagtttg acatcggaca ttcttcacac 48600

atttgctagg gcatgtgcat gccttcgctc acaggaacat atacacatat gcgcgcacac 48660

aggaattttt ttaaaacaca catttttctg gagaataatt tattcgtttg tttgttattt 48720

ggttggtttt ctggaggcaa gatgtcacta agtagctctg gctgtcctgg cactcactat 48780

gtagaacaga ctagacttga actcacacag atcaacctcc ctctgcttct acagtgccag 48840

gattaaaatg tatgcatccc catgcctgat taagaccatt gtattttcaa aacaaacttc 48900

acattcctgt gggaaatgct cacaagtata gctataaatg cagataaata gagtcattat 48960

ttttctgtat caacattggc tctggaacaa atgtttaaag agctgatcca aaaattagat 49020

ctcaggagga ggagtattgt tattttctaa aatgttcaga tttctgcttt acttttcaac 49080

tgtatgctga agtatctttt tttcacagca ttaaaatacc tttatttgta attagatttt 49140

aaaatactgt caaaaattat gccaggaaac aggaaggaca cagcttaccc tagagggaaa 49200

aacaataaat ccaagacaga tgatttcctc tacaagggtt tttcttggca aacagatata 49260

taagcagaac cagggcactc acagtagata gcaactgcac agacaggttg ggagtttaca 49320

aaaccaaaac ttgcattgtt gaggaaaggg aaatgacaca gaggagcata ttgactggag 49380

aatacccatt gtctgaattt tttttctctc ttttctgttg tgacatttac tacttagtaa 49440

cacagtaagc taaacaacca gtgccatggt aggcttgagt cagctctttc aggttcatgt 49500

ccatcaaaga tctacatctc tcccctggta gcttaagaga agccatggtg gttggtattt 49560

cctactgcca gacagctggt tgttaagtga atattttgaa gtcctaaaaa ttgtgttgaa 49620

ttttatagca ttatccatca ctttgcatta tttacttttt tcaaaaaaat tgacaatctc 49680

atgactgcac ataatatatt ttgatcaatt ccactacatc ctctttaata ggacaatagg 49740

aggtgctgtt tgggttccta tagaggactg atctcacagg aggaagtatg ccactttgag 49800

gaattggatt tgaggtctca atgcaatgct tgtctacttt tctctgttta ccacttttgg 49860

atcaagatgt aatctcttag cttctggatc gagacagtgc catgataaag atggaaactc 49920

atacctccga aacagtgacc ttgaagaaaa acttccttct gtatgttgca ttttctactc 49980

taacaaattt acttttgtag tgctccaatg agtaactgac atatcaatta aaagtggggt 50040

taggggagac atactgactt gaataatttt tgcactatag tgtaggtttt gacaatttct 50100

acagtgtttt atatttcaga actgtgttcc tgagatgtgc gatatctcag ggggtaatga 50160

tgactgagtt ttgtgaccta cttagtagga gaagaaagaa ccagtatcca ccagctatct 50220

tctgacctcc acacacatgc caaggtatgg gcatacccag tcccatgtac aaaataaatg 50280

ataaagtttt aacatgtatt atgcacaaat ccaaaattaa taaggacact tactacgtgt 50340

ataactgaaa cccaaagtaa ttgtaaaatc aagtatttca tatttctctt tcatgtgcag 50400

atggataaca gaagtcaaaa ctgtctttct ggctgtttta atataacata taattctatg 50460

caaaaaatac tgatactatc ttttaaaaag aaaaaaactg tatatgcata cattatttca 50520

tattaaacac tattaagaag aaatgagtgc aaacattgta tttcaaattt cagattaatg 50580

gattctgaca tgtggaaggg ttacatttcc caaatgtctc atcagcacag gttcctgaaa 50640

actggggaaa cccaggacta atgagatgga ttttcacata gaggtggata ctgccaagcc 50700

tgggtacctg agcccacaca cccatgaact caaaataatt tttaaaaaga agaaatttaa 50760

aatttaacta tatatattat gattatccaa taagctttct agatgtttct ttggttatat 50820

gtcataattg tcgtgattga caagctgtta aatttgagtg atgtttgtaa agaaataaca 50880

ataaattata tctatagaag caagacttca tctttaggat caagactgta tgctccatgt 50940

tatcacagct gtttaaccag acaaaggcta gaacctccag ttccacaaac aaatgtgaat 51000

tctactgtgt ccagtttact gccatgtttt tggtcatgtg aacaatgtgg tttgtgccaa 51060

cattagagca gagttcacaa gtgcattttg cctccccagt attgctgatg aatccatggt 51120

tcaggttcaa gggtgttgaa aacttgattg aaaatggtca gacttgatat tcttccagta 51180

tatctgattg gaggaactga taatagatat cagatttaaa cctctaccat tccagttaag 51240

ataatatgat agcatcttgt tcttcatctt cctttttctt aatagggaca taaaaccaat 51300

gaataaaaat atacctgaaa catgggatag gcactgggca ttggaaatga caataaaagt 51360

aaattttcca tccctagtaa agttctccag gaacctattt gtatactaaa tgacacaatg 51420

tcaatgtcag tgcacaactg ccaactggga tgcagaacac tgctcacgcc aaccatcctg 51480

aaagccaact ataaaaagca gagagatact ctgcaccttt tcagtgaggt ccagataccc 51540

acagagcaga gacagtcgct cacac 51565

<210> 7

<211> 107376

<212> DNA

<213> 人工序列

<220>

<223> 合成多核苷酸：107 kb 3'臂序列(58665-166040)

<400> 7

ctcaacaaga tcaggattag gtgagtcaaa gcacattaat tttatatctt gaagttttaa 60

ttttaatttt attttaatat ttaagttatt aatatttaat atttaaagta aataatattt 120

tatttgttct ttatcctttt catatattta tataatgtat atttatcttt catacttcca 180

cacacctcat ccaagcaaca catctccctc tatacttcat ggcttttaaa ttttattatt 240

atttattatt attattacct caatgaatcc aattggtgct atttctgaat agggtatgtc 300

aattcctgga ggcatgagta atgtaatata ccagggctat tatgtaatat aaaaaaatgg 360

actgcaggga gctggtggca catgcattta acctagcgct caagaggcag aagcaagcat 420

atgtctgcgt tttagataac cctagtctac agagtgagtt ccaggacagc aagggctact 480

cagagaaacc ctgtctcata aaaccaaaaa gtatattttt taaaggcaga agaggaaagg 540

agggagggag ggagggaaag aggcagacag acagacaggc aggcaggcag gcaaaaagaa 600

ggaaaaagaa aaatatggac cctccctctc ccagaaacta tcaactggca atagctcttt 660

ggtggggggg gggggtcctg aatccctctc tgctcaattc tagaatgtta attagcttga 720

tctgaccagg gtcttgtgca gaacaccaca gttgctgtga gttcatgatt gtaacagatc 780

tgtcatgttc agaaaacaga attttatggc tctactcccc atccagatga taattgatgg 840

ctaagcatcc acagtcactt gtcctcatcc tttgaccagc tacaaatttc tgcacaaacc 900

actccccact gtaaaaagtt gagcagaagt caaacatgga ggcacacacc cttaatccca 960

acacttggga ggcacgggta gatgaatctc tgtgagtatc aagccagcct gatctacata 1020

ctgagctcca gaagatccag gtacatagtc tctatctaaa caaacaaaca caaagttaaa 1080

aagttgattt gaccaaaatt gagagaagca taaatctatg agtattttta agaccgtggc 1140

ttggaaacat gacagttcat caccactggt ctccttcata ggctccatga gctccattgt 1200

cacaggcttt tgactcgaat tacaatagaa acccaccctt acccctgttc ttccatagat 1260

atgaagttcc ttccatggag ctggcatgaa atttaatcag agagtgcttg gctccccaat 1320

acagccttta ttgcaccagt ggacgcaagg atgattttat agtgtgttgg ggaagcatgg 1380

tgacatcact gacatcttat cccacataca cagcctatta agtacatcta agcactgtga 1440

acgagtttcc tagtccattt gacatcgatt tcttgatgcc ctacagccac agcatttggt 1500

gtcttcagca atagtgccct accatttaga tatggtgtat agtcaagaga tatggcaata 1560

gccaagttat tttggttatt ccaaggcttc cttccattaa taaatatcat ggtggtaccc 1620

ccatgactaa aaattagatt ttcactgaat aaaccatgtc ttctgggaac agcattatac 1680

cattgcaggg atcctctgct gaaacttttt taatactata tttttactta gcttacaaac 1740

tagtggattt ctgtaagact tcatttacct tcagtttcag ttgaccctcc cctaccctgt 1800

tcttccctat gcccaaacac atccacacct actcctctag cccacagctc tcactttcta 1860

atcttccctg tcaccagtgc ccaattatat cgcctgtatt attatatttt aatcacacaa 1920

ccataggttt ccatatgagg ttttaataac ccttcattct ggttaaacct tccaccacac 1980

cctgatttcc ccattccaca accaactcca tgattaagcc ttcctgcccc aagtattctt 2040

ctttatactt cattttaatg gcattacatt tgatggaccc acttccttga tggacccaat 2100

tcaaaccagt ttctaattac ctggattcct tacatactcc atattatgca tacaaaataa 2160

aagattcaag tctaatgtcc acatgtgaga tagaatgtgc agtttgtctt tctgagcctg 2220

agtggcctca ttaagtataa taatttccag ttccttctat ttacttggaa atttcatatt 2280

ttcattgttc tctatggctg agtaatattc catcttatac attacatttt ccttatccat 2340

tcattagttg atgaacagtt gggtcaactt cgtttcttag ctattatgaa cttaacctca 2400

gtgagcatgg acattcaaag gtctctgtaa cagaatataa acccctttgt gtacatatct 2460

agaaatggag gaactagaga aagcacccaa ggaactaaag ggaactgcaa ccctataggt 2520

ggaacaacaa tatgaactaa gcagtacccc ggagctcttg tctctagctg catatctatc 2580

aaaagatggc ctagtcggcc atcactgcaa agagaggccc attggacttg caaactttat 2640

atgccccagt acaggggaat gccagggcca aaaagggggg atgggtgggt aggggagtgg 2700

gggggggttg gggacttttt gtatagcatt ggaaatgtaa atgagctaaa tacctaataa 2760

aaaatggaaa aaaaaagaaa tggtgtaact gagtcacatg ggaagtcttt ttctaatctt 2820

tggatttgtt tatttgatgt tcatagtttt tgggttttgg ttggttttgt tctaagttct 2880

ttgtatattg tagacactaa tcctccatca catgtgtagt tggcaaagat ctccattccc 2940

cgagatacct gtgcatttaa ttgacagctt cctttgccgt agtttttaat tccatgatat 3000

ctgacaagtg tttgtcttac tttcttgcta caagaatcct attcaaagaa tccatacctg 3060

tgtctatggt taacacacac tccatgcttt cttctctatc agcttcaggt taccatgtct 3120

tatgacacgg tctttgaatc atttggagtt gaggtttttt tcaaggtgac agggaagagc 3180

ccaggttcat ttctctgtat cctgatgtcc actttttcct attcggtcta tttatggaat 3240

tatatatttt tatgttaggt catttttcag tggaggcatt aacaatatcc agaaggggac 3300

tatttcttac tagtgttgag atggtattct cctatatggg gctggtactg aaggcagcaa 3360

gttctacccc tagtcttcct gtgagattca actactatct gggacctcga gtgagactct 3420

gtctgtagga tacatggggc ttggtaaact ccaatgtgaa acaaaaaata tataatttta 3480

gtttagattc atagaaacta catcctcaaa taaacacata agttctaaaa agtaccaatt 3540

taggtcttga tataagatca tttgtcatat aaaaattttc catataagga aaatttccat 3600

acaaagttca tgtatatttc caaatataca aaattctgta aaatgttttt gcatgataca 3660

tcttgtcatt gtttgcctct ttaatggctt gtatttgttt cattttctac tctcatcaaa 3720

tatcatgtat tactatccta aatatatgaa ataattctgt tccagcatta cagatgacat 3780

caggaatttt ccagtatatt tttcctggaa cctgaaacat caatatgaag atgaagcaat 3840

cttgtctctc agatcatatt ttcctattta ttgcaaatta caattcctgt ctctgtactt 3900

tctctttcac tcattgtttc ccatgttcta atcggtatta gtgcatcttt gaatgtttaa 3960

ataaatttat tttacttgca tacgtgttgt taaaagggga agctaaagta caatgcacat 4020

aaatacctat ttgacttttt ttaaaggaga ggagggttgg aggggtggca tgtgattgct 4080

cacgcctgta atttcagcac cggggaaaga ggtagagaca gttgaatcct ctgatgtcac 4140

cagtagccag cctagactac atgaaatatt gcaggccagt gagagatcat cccagaaaac 4200

aaggcaggga catgacaggc agctcagtgg tcaagagcac tagctgctct tccacaggac 4260

ctgggttata ttcctaacac tcacatgaca actcacaact ttctgtaatt ccagttccca 4320

gggatttgac atatatatgg acaaccatgc aagcaaaaca ccaatgcaca taaaatttta 4380

aaaaactaat tcaattaagg cagatgtgaa tgaaggatgc cacctgacat aatcctgtgg 4440

cactcaacat ttacatgcac acacttgtgt ccatgaacac aagtgcaaaa atacagagag 4500

agagagagag agagagagag agagagagag agagagagag agaacataca ccaaagagtc 4560

tcatcattcc tacatgttac aaactccaat attgtaattt tgactttaga aaggaaggta 4620

aaatattata ttggttgttt aaagtaaaca tttaaaaact ttgtagcaga aaatggccta 4680

gttggccatc attggtagga gaggcccttt gtcttgcaaa gattatatgc cccagtacag 4740

gggaatgcca gggccaataa gcagaagtgg gtgggttggg aagcagggtg gggaagtgta 4800

tagggaactt tcaggatagc atttgaaatg taaatgaaca aaatatctaa taaaaaaaaa 4860

gctttgtgtg ctagtagttt gtcaacctga cacaggccat agtcatttgg gaaaggagac 4920

actcaagaaa atacctccac caggttcaac tgtggagcat ttcttgactg gtagtcaatg 4980

tgagggcagg tcctactcac tgtggaaaac actgccaagc aaaccatgag gaaccagaca 5040

gtaagcagaa ctcttccata gcctctgtat cagtttctgc ctccaagtct ctgccttgac 5100

ttccccaagg tgataagcta caagtggtca gatgaaataa acccttttct ccctaagatg 5160

cttttggcca tggagttcac aaaagcaata gaaaccctaa gacacagagt aatgttgaag 5220

agcttagatc acaaatcata tcttaaagtt gaaagaaacc accccacaca cttgtatgca 5280

tatatacaaa ttcacatgtg gacaaacata catatatact caaaccatac atgtatgtat 5340

atttaaaaat ttgaaatgtc acaggaagaa ttattttgta gtctttgaac tactttgatt 5400

tatttacttt aaccacttgc ctgctattgt tgggttcaat ggtcatgctt tcataatgcc 5460

ttctaaatat taatttgcat ctctggacca ggatcatgct caacttttgt cagagaagct 5520

tgtttttgtg gtgagatgaa tgttatgaca ctgaagtttt tgcatcacgt tctgacatat 5580

gtctatccac ctaccatttg atcacccact acgtgtgtgt gtgtgtgtgt gtgtgtgtgt 5640

gtgtgtgtgt gtgtgtgtgt gtgtgatttg aatgagaaca gcccccgtag gctcatagat 5700

ttgattgctt gatcactaag gagtagcact atttgaaagg ataaggagat gtggacttgg 5760

aggaagtgag tcactgagga tgagctttgt ggtttcaaga gcccaagcca gaccctgctt 5820

cctcatccta cttgctatgg actcagatgt aaaaatctcc actccttcag caccatgtct 5880

gcctgtgtgc taccatgcca aaaaatggaa taaatctctg acactgtgtg accctccctg 5940

ccccgagaat tgttgaccta tattggtcca tgaggagcag agacaatggg gaaagagcag 6000

gggcttagaa accctgtatg tatggtaata acgatacaca gggaccagct tcagagagac 6060

aggtcaagtt tacttgtggt gattcaaggg tgatatagtt gtcttagtta gggtttctat 6120

tgctgtgggg agaaaccatg gccaaaaaca caaatgagga ggaaaaggtt tattgggctt 6180

acacttccac agcactaatt atcattgaag aaagtcaagg cagaaactca aaccagacaa 6240

gaacccagag gcaatagctg atgcagaaac catggaaggg taatgcttac atattactca 6300

tggcttattc agcttgcatt agctttttat tattattaat cattccatta gtttacatct 6360

caaatgatat ctcactttca ggttaacccc tccaccaatc cccatgaata ataacccaat 6420

tcctggatac ccctccattg acccccatcc cacatccacc ctccaccttc ccctttgctt 6480

gtatgagatt tctcccccat ccactcacat tctctgaacc cactgctcca gcatccacct 6540

acactggtgc atcacccctc ccattgctgt caggcaaggc catcctctgc tacatatgta 6600

tctggagcca tggatccatc caggcacact ccttggttgg ttgtctagat tctggaaaaa 6660

ctaggtgatc aggccagcct aagttgttat tccattgggg tagcaattcc cttctgttcc 6720

tccagttctt ctgccagctc ccccaccagg ttccctgagc tcagtctgat ggttggctct 6780

aagcatccac atctgcattg gtcagttgct agccagactt cccaaggaac tgccacacca 6840

ggttcctgtc agcaagcacc tcttgaccat ggcaacagtg ttaggtttgg tgtctgcaga 6900

cagggtggat ctccaggtgg agctttcccc aaatggcact tccttcagtc tctgttcaat 6960

tttttgtccc tgttcttctt ttggatagga acatttatgg gttgaaaatt tgagatgggt 7020

gggtagcttc atcccttgac ctggagctgt gcctatctat tggaggtggt ctcttcaggt 7080

tctgtctccc ccttctctgt gcatttctgc taatgtcatc tcctttgggt cctggtagcc 7140

tcatgtttcc ctggtgtctg tgaccctcca gtgactgtcc ccagttcctc atttcttact 7200

gctacatatt ttttgttcga tatcttgacc ttctgtatct ctttgacatc tcctccagtt 7260

cctgatactt ccctccttat ttcctcaccc tcctctctcc ctcccaggtc ttcctctaat 7320

agaacaaaaa atggggaaga gactcaaata cttgggcaca gaagaaaact ccctgaagat 7380

aacaccaatg tgttatgctt taagatcaat tgacaaatgg gacctcagaa aatgaaaaag 7440

cttctgtaag gcaaaggaca ctgtcaatag gacaaaacag tcacccacag attgggaaaa 7500

aatctttacc aaccctacat ctgatagagg gctaatatcc aatatataca aagaacttag 7560

gagttaaact ccagagaatc aaataactct actaaaaaat gagataaaca gagaattcat 7620

gactaaagaa acttgagtgg ccaagaagct cctaaagaaa tgttcaccat ttgtagtcat 7680

caggtaaatg caaatgaaaa caaccctgag ttcctacccc acaccagtca gaatggctaa 7740

gatcaaaaac tcaaatgaca gcagatgctg gtgaggatgt ggaataagat gaacactcct 7800

ccattgatgg tggggttgca agctggtaca accactctgg aaatcagact ggtggtttct 7860

cagaaaattg gacatagtac tacctgagga cctagctata ccactccagg aagtataccc 7920

agaaaatgct ccaacatgta ataaagacac atgctccact atgttcatag cagtcatatt 7980

tataatagcc agaagctgga aacaacctag atgtccctca acagaggaat agatacagaa 8040

aatgtgatat atttacacaa tggagtacta tgcatagatt taaaacaatg acttcatgga 8100

attcacaggc aaatggatag aactagaaaa tatcattctg agtgaggtaa tcaagacaca 8160

agggaacaca catggtatgt actcactaat aagtggatat taacgcaaaa gctcacaatt 8220

gccataatac aatccataga ccatatggag catagaaaga aagaccagga tgtggatgct 8280

tcagtcttgc attgaggggg gatcagcttg cattcttaag aaacccaaga ctatcagccc 8340

aagggtaaca ccactcagaa tgggctggtc cctcacccat caatcactaa ttaaaaaatt 8400

gccctacagg cctattgagg cactttcatt tttttctttt tttattagat attttcttca 8460

tttacatttc aaatgctatc cactataccc tccccccaac cctgctcccc aacctaccca 8520

ctcctgcttc ctggtcctgg cattcccctg tactggggca tatgatcccc gcaagaccaa 8580

gggttgaggc actttcttaa ttgggcttcc tttctctcat atgactacca cttgtgtcaa 8640

gatgacataa aactatgcaa cacagacagt atatacatat gtattatcta tcatctagaa 8700

attcatcatc tatgcattca tcatatatct atccatcatc tatcaataca tcatttgttt 8760

atccatcatt tatctatgta tcatctattg tcgctctgtt caccctctac ccatctatct 8820

attaaaaaat taacttgatc agggccatag tgacacaaac ttttaatccc agaatttggg 8880

aggcagaata cggctagcct gatctacata cagagtaagc tccaggatag ccagagctac 8940

acaggaaaag gttgtctcaa aacaacaaaa aataaattaa tgtgtataat gatcaaggaa 9000

gacacttaac ataaatttca tcatctatgg gaatccatga acctgcacac ataaaaacgt 9060

atgtttactg aatatacata cacctggagt atttaatttc tgaagtacac tagtgaaatg 9120

tcccatctat ccacacaact ctagggatct gggttaaatt cctgggacac aagtaaatga 9180

gggagggggg agaacagagt ctccaaaagt gtcccctgaa gtccatacat gtgctggcta 9240

tggtgtatac acccactcct agacatgcac aataataaat aactttccta aatacagaag 9300

aatctaatta cctcaaaaag agatctttat tacagatttg ttcaaatgct agactataaa 9360

agtttactca gatagcatgt aactttttga tatcctgttg ttcttttctc aacataccag 9420

agatgaacat aaaaaagagg tatgttttcc tcttttttga atatatattt aattggttgt 9480

attgatgaca caagattcca atacacctga tcatgtatga catattagtt tcttttggcc 9540

aactacttgg cataaacagt ttgagaaagg aagtgctgat tcactcatga tttaagatag 9600

tgtacagccc atcatagtgg gacagaaact ggggcatgta ggcctactct gtgacacacc 9660

attaagaaat atcactgact gtccctactg caaaagccat tactcctcca tagtgcctca 9720

gttaggagta gacctataag tgacatccat aactatgcat atatattaat catctcttta 9780

ttgattattt catctatgca tgcatccaac catgcatcta tctatctatc taatctatta 9840

cctatctatc tatcaatcta tcaatctacc catcatctat tatcaattga tctatcttat 9900

agtgatatat catttcattc tctataatct acccacttat aatctatcac atattcttcc 9960

atcatctata tcaatccatc atctgtctat catctaatca gtcttttttt cacctgtcat 10020

ctaccaatat gtttccttta ctactatcat gttctatatt gtgacacagc ctcactaaga 10080

agcccagaaa cttactttac aacactagct ggacttgagt tccatgatcc cacattctca 10140

gacttacaag tatatgtgat tacatagata aatagatagg tttataggta ggtaggtagg 10200

taggtaggta ggtaggtagg taggtagata gatagataga tagatagata gatagataga 10260

tagatagata gatagataaa tagaaagaaa tatatgtgat agattcataa ttgatagatg 10320

attgatagat caattgagag acagataagt acatatataa gaagatagat ggatagagag 10380

atatcaatac agaatgtata gatagaaata gatacatata gatgatatag atagattaat 10440

tagattgata aacacagaat atacatagat gcttatatag atggtagtag atgtatagat 10500

aacaggtgga gagttagatg atagatttta tgttagacaa gcatatgata tctataaaca 10560

tatgtgtcta tgttatgtag ataggtaata gattaatgat acacaaataa atggttgata 10620

tatggatgag tgaatggata gatatatcca taagtatatt tcagtatata ttaaactgaa 10680

atatttctat tgatatatga acatatatac tttttataag tatactaata tgtttgtaaa 10740

tatttagata tctgatgtat atacatgtct atcttatata tagatgtcat cttcctatct 10800

atacctcata tatcaataat ctgtcatcta cctatgttat aactcattaa cccagttaat 10860

catacacaaa ttcaactaaa ataaattctt cctcttttta ttggatattt tatttattta 10920

catttcaaaa gttatccctc ttcctggttt tgcctctgaa aacccctatc ccatctgccc 10980

tccccctgca tctatgaggg tactccccaa cccacccacc ctcccactcc cacctcacca 11040

ccttggcatt ctcctacact ggtgcaccta gccttcacag gaccaagggc ctctcctccc 11100

atgatgccag ataaggccat cctctcctac atatgcagct ggagccttgc aaaccccttc 11160

aattccttca gtcctttccc taattcctcc attggggtcc ctgtgctcag tctaatcaat 11220

gattggctgc tagaatccat atctgtattt gtcagactct gtcagagcct ctcaggagac 11280

agccatacca gggtcctgtg agcaagcact tcttggcata ggctgggttt ggtgtctata 11340

tatgggatgg atacccatct ctagatggtc tttacttcag cctctgctcc acactttgtc 11400

cccatattcc ctttagacag gagaaattct gggttaaaat tttagagata agtgggtggc 11460

catatccccc aactaggggc cttgcctatc ctctggttat ggcctctaca ggtcctccct 11520

ccactttgtt gggcatttta gctactcatc tccactgggt cctgggagtc tcttgctttc 11580

ctggcatctg agacattaag gtagctattc ccagttcgcc atcccccatt gctagacacc 11640

tctcttcaat ttcctgaccc tctgtgtatc atacccatct ccttccatac ctgatcctgt 11700

ccccctttat tgtgtctcct ttctctcttc ctcctaagtc ctttgcaccc tctacctcct 11760

gtattttgtt ccccattcta aagaggacta aagtatccac acttgctctt ccttcttctt 11820

gagcctcata tggtctgtga gttgtagcat gggtattctg agctttttac ctaatatcca 11880

cctatcagtg agtacatatc atgtgaccat gtatgttctt ttgtgactga gttacctcac 11940

tcaggatgat attttctact tccatccatt tacttacgaa tttcataaag tcgttgtttt 12000

aatagctgag tagtactcca ttgtgtaaat gtcccacatt ttctgtatcc attcctttgt 12060

tgaagggcat ctgggttatt tccagcttct ggctgttata aatatgtctg ctatgaacat 12120

agtgaagcac gtgtccatat aatatgttgg agcatctttt gggtatatgc acaggagtgg 12180

tatagctggg tcagcaggta gcactatctc cagttttctg aggaatagcc agactgattt 12240

ccagagtagt tgtaccagtt tgtaattcca ccagcgttgg gagagtattc ctctttatcc 12300

atatccacac cagcatctgc tgtgacctga ggttttgttc ttagccattc tgcctggtgt 12360

gaggtggaat ctcaaggtca ttttgatttg catttcccag atgattaatg atgttcaata 12420

tttcttaagg tgtttcttgg ccattcgaga ctactcagtt gataattttc tctttatctc 12480

actacccaat tttaataggg ttatttgatt ctcaggactc taacttcttg aatctttgta 12540

tatattggat attattcctc tattggatgt aggattggta aagatctttc ccaatctgtt 12600

ggttgccatt ttgacctatt gacagtgccc tttaccttat gctttgcaat tttatgagga 12660

gtgtaaaata ttatggagtg taaaaatgtg aattaaaaat aaaatttaaa aaagtctaaa 12720

ttttttagtc tctttctcta tttcttccct gcccatgtta tcattgagta gagagttgtt 12780

cagcttccat tcctatgtga gctttctgtt gattttgttg ttattgaaga ccagccttag 12840

tcggtggtga tctgatagga tgcataggat tatttcaatc ttcttgtatc tattgacacc 12900

tgttttgtga cctattatgt ggtcaatttt ggggaaggta ctatgaggtg ctgagaagaa 12960

ggtatattct tttgttttag gatgaaatgt tctatagata tctgttaaat ccatttggtt 13020

cataacttct gttagtttca ctatgtctct gtttggtttc tgttttcatg atctgtcaat 13080

tgctaaaagt ggggtgttga agtctcccag tattattgtg tgagtttcaa tgtgtgcttt 13140

gagctttagc aaagtttctt ttatgaatgt gggtgccctt gcatttggaa catagatgtt 13200

cagaattgag ggttcatttt ggtagatttt ttcctttgat gtgtatgaat gttatctttt 13260

ttgataactc ttggttgaaa gtcgatttta tttgctatta gcttgtttct ttggaccatt 13320

ttcttggaaa attgttttcc agccttttac tctgagatag tgtttgtctt tgtcactgaa 13380

gtgcatttcc agtatactgc aaaatgctgg gtcttgttta catatccagt ctgttagtct 13440

atgtcttgtt attggagaaa tgagccaatt gatgttaaga gatattaagg aagagtggct 13500

gttgcttatt gttgtttttc ttgttggagg tggaattatg tttgtgtgtc tatcttcttt 13560

tgggtttgtt gaaagaagat tactttcttg cttttcctag ttataatttc cctacatgtg 13620

ttggtgtttt ccacaaatta tcctttgtag gactgaactt gtggaaagat gttgtgtaaa 13680

tttggttttg tcatggaata cttgggtttc tccatctacc gtaattgaga gttttgctgg 13740

gtatagtagc ctgggctggc atttgcattc tctttgggtc tgtataacat ctgtccatga 13800

tcttctgact ttcatagtat ctggtgagaa gtctggtgta attctgatag gtctgttttt 13860

atatgttact tgaccttttt gccttactgc ttttaatatt ctttctttgt tttgtgcatt 13920

tggtgttttg actataatgt aagagaagga atttcttttc tggtccagtc tatttggagt 13980

tctgtggtct tcttgtatgt tcatggacat ctctttcttt aggataggga agtttccttg 14040

tataattttg ttgaagatat ttactggcac atttagttag gaatcttcag tctcttctat 14100

acctattatc cttaggtgtg gtcttctctt tgtgtcctgg atttcctgga tgttttggat 14160

taggagcttt ttacattttg cattttgcat tttctttgac tgttgcataa atgttttcta 14220

tgctatcttc tgcccctgag attctatctc ttgtattttc ttggtgatgc ttgcatctat 14280

gactcctgat ttatttccta ggttttctat ctccagagtt gtctcccttt gtgatttctt 14340

tattgtttct atttccattt ttagatcctg ggtggttttg ttcaatccct tcacctcttt 14400

ggttatgttt tcctgcaatt ctttaaggga tttttgtgtt tcttcttaaa gggcttttac 14460

ctgattacct ctgttctcct gtatttcttt aagtgagtta tttatgtcct tcttaaagtc 14520

ctctatcatc atcctgagat gtgattttaa atcataatct tgcttttctg atgtgttggg 14580

gtatccaggg tttctgatga ctccaagtag ccttggtttc tgttgcttat gttcttatgc 14640

ttacctcttg ccatctggtt gtctctggtg ttagctgaac ttgttctctc tgaatggatc 14700

ttatccctcc tatgagcttg tgagcctgtg atcttaggtc tatcagcact cctcagagac 14760

cagttctttc tgggtggggt ttgggtaagg agaactgtag cacagggtta tctcaggggc 14820

acagatggaa accagaagct aagttcttcc tcttatatct gcgcctcaac atacccacat 14880

caccttgaac ctttcctaaa tataccatca tgatttatcc cattccagta gttgctttac 14940

actatatatt tatttcaatt ttatcctgga gctatgtata gcaataaagt caatttggca 15000

agagagttca ctgacatctt ttatttaaaa tgtgcataga accctctaaa attggctgct 15060

taatatggtt tttgatttgg tttgattttg attttttttt tttttttttt ggagacaggg 15120

tttctctgtg tagccctggc cttcctgaac caggctgggc ttggactcag aaatctgcct 15180

gcctctgcct ctgttggaat taaatgtatg tgctacgacc acctggcaag ataatatgta 15240

tttaactcag tctgaaactt cttataatct actgttcctg tattacctgg aaccaacctc 15300

cctaggcacc attgaccatg tgttgtgagg attaattctt cactaaacat taatttagta 15360

tcacaagtat gttttacatt tttttctaaa agtgtcaaat cactttacac cactttccaa 15420

actgcttcat aatttagttt gtttttattt aattctgtgc acacttgcaa acaaaagctt 15480

tcaaggattt cgtcagagtt gaaaaatctg tatttgtaga tttttatttg catttttgca 15540

aaactgcata aattaatatt tgcattttat gactacaagc gagcctgata aattttgcta 15600

ctaacacaca ttctgatatg tttctgtgtt aagtaaatgt tttaattctc aaatcttaat 15660

ctcatacatc tggaagagga ggtgaagagg atctcaaaga agttgtggag gggaaccata 15720

atcagattat attgcatgaa aaagagtata ttttcaatta aaaaaatgta aagctcatct 15780

atctgccata aaagtcaatt cgcttataaa ataacatttt taaatttttt atttgatatt 15840

ttctttattt acatttaaat gttatcccct ttcccagttt ctcctctgaa aaccccctat 15900

ctctttcccc ctccccctgc tccccaaccc accgactcct gcttcctagc cctgacattc 15960

tgctatactg gggcatagaa ccttcacaag accattgatg accaactagg acatcctcta 16020

ctacatatgc aactagagcc acaagtccca ccatgtgttt tctttgattg gtggtttagt 16080

acctgggagc tctgagggta tgaattggtt catattgttc ttcctaggag gctacaaacc 16140

ccttcagctc tttgggtcct ttctctagct ccttcattcg gggccctgtg ttcagtccaa 16200

tggatgactg taagcatctg cttctgtatt tgtcaggcac tggcagaccc tctcaggaga 16260

cagctatatc atgctcttgt catcaagctc ttgttggcat ccataacagt gtccgggttt 16320

ggtggttgtt tatgggatgg atcctcaggt ggggcagact ctggatggtc attccttcag 16380

tctctgctcc gaattttgtc tctgtacctc cttccatggg tattttgttc ccccttctaa 16440

gaatgatcga agtatccaca ctctggtctt ccttcttctt gagtttcata tgctttgaga 16500

aatgaatctt aggtattctg agcttctagg ctaatatcca cttatcagtg agtacatatt 16560

gtgtgagttc ctttgtgatt gtgttacctc actcaggatg atgccctcca ggtccatccg 16620

tttgcctaag aatttcatga attcattgtt tttaattgca gagtagtact ccattgtgta 16680

aatgtaccac attttctgta tccattcctc tgttgaggga catataggtt ctttccagct 16740

cctagctatt ataaataata ctgctatgaa cgtagtggaa catgtgtcct tattacatgt 16800

tggtgcatct tctgggtata tgcccaggag tggtatttct ggaccctccg ctagtactat 16860

gtccaatttt ctgagtaacc gtcaaatgga tttccagagt ggttgtacca gcttgcaatc 16920

ccacggatac tgtcaataag acaaaaaggc aaccagcaga ttgggaaact atctttatca 16980

atcctacatc agaaagaggg gacatatcca atatatacaa agaactccag acatccacat 17040

aaccctattt aaaaatgggg tacagagctt aacaaagaat tctcaactga ggaataccga 17100

atggctgaga agcaactaaa aaatgttcaa tatccttaat catcagggaa gtgcaaatca 17160

aaacaaccct gagattccaa tacctcacac cagtcagaat ggctaagatc aaaaactcag 17220

ttgacatcag atgatggcaa ggatgtggaa aagaataaaa tgacaatatt aactgtgtct 17280

gttttacaag agtttctcta taatggcact ttctttccac agctcaatga gaatttgata 17340

tattgatttt taatgtgtat tatcatgtac agttggcata tgtgctgata tgtggtgtga 17400

cagaaaatac agtgaaaaat attcacaggc ctactatttt gaaaattctg gttttatgtg 17460

cataatttgg aatagattct cagacccctt ctgtggggaa atattggccg ctctatggtt 17520

ctggttatat accccagagc ctttggggac aaatacttct aaatattaat ttttcagcta 17580

tatttttata ataaaatttg agtgtgttca caggcatatt tcctttctgt ctgccatctt 17640

cataatatga gcatgcctag tggtgttgct atgctttcaa acaaatgatg cataatttta 17700

caggaatcat gaccaaacat gcatcatgct attttgtttc tgaaacaaag aactttaaac 17760

tgagcatggt catgaatgtg catcttcact gtgcattttc agaaatgtgt ctgctcacaa 17820

atcatttttc tatatgaata tgcaaaggtc ccctgattaa atgtcactct ttaattgttg 17880

aaggaattgt cattactttg gaaataacct catgtgtcat ctattacaca aaataaatat 17940

ttttgtacta tgttcactct gtaaacacca aaatgtgaat tcacagacca aaagaacaat 18000

tcttatcaaa tatgtattac acacataaca gattcaaata cttttagggt gtattgtgtt 18060

attattattc tcttatacca tcataggctt ctcagtgttc tccattgttt acttcatagc 18120

ttcgtgctac atcctggtta gcatgaaatt ggaattttct gtgctgggca tatttttgtt 18180

tttctgaaca gaaaattccc cattcaggct cctgaaaaac tttctgcatt tgagtagaac 18240

agatacattt ttaaaactta catttaaatg ttctttcttt tcctatctaa agaatgttgt 18300

tagctttctg gaaacttcta aacaaaaacc tggtccaaat caataaactt ttataaaata 18360

actccctatg gtttagccaa tgcacagtaa tttatatatt tcaccaaact aagtgatgat 18420

acacagacat tttttatatt atgctgactg aaacttatta tcagatgatt gagaattttg 18480

agcactagtt tgaatggaaa attaataata acaataataa taaataaaat ttattataat 18540

tttctaagga tatctttgtt aacattttgt gtcaggacac tattgctcta atatgaaaat 18600

ttgaggtttc ttttctcctt ttgagacatt tgaaagagtt tgtgaagcag gaatgatgtg 18660

ttggctcagt ggacaatgaa gcttgtcacc aatcctcatg acttgagtta tagcacaagg 18720

aaccatgttg tagaaggagg ggatcaacac ccaaaagtga tcttctgggc tctgtggcat 18780

agacatacat atacacacag taaatatttt ttaattaaat taaattaaaa ggtcataaag 18840

tcaaggtatt aactaccact gattatccaa tccctgactt tgctttgagg atgaaaaatt 18900

ttttctaaga gaggttttta attaatttat ttatttgttt gtttgtttat tatgtacaat 18960

gttctgtctg catgtatgcc tccatgccag aagagggtaa aagatctcct tatagatggt 19020

tgtgagccac catgtggttg ctgggaattg aactcaggac ctctggaaga gcagtcagtg 19080

ctctcaacct ctgaaccatc tctccagcct tgttatagat ctatttggtt acctgtctat 19140

ctatacatgt atctatctct ctatctgata ctttctgcct tgcaggagtg tgttcatttt 19200

aactgtgcgg cctagacacc accaaaagat tagttatcac cattcttaca gtttagattt 19260

cagcaaattc aaactaatgt agctttgatt tctcattgta tttgctactc tgtcaatatg 19320

acttattttt ttcctcatgt tgatctctac ataatatcag cctttgactt tgttgacttt 19380

ctccctactt ctttattttt ccttaatttt actataatat gacatatgca gcttcctcta 19440

atacgtggtt taatttggtg ttaatgatgg accatattga gatgagtgtt tagattgtta 19500

gccatgcaat attacagtcc tgacataaag acgttgacaa ctgtacattg tccatttgct 19560

accatgagtc ctagataaaa tgtacaaaat cctacaaatt tggccagatt ccattttctt 19620

ggaaacattg aaatcaaatg ttattctttt ctcctttgac agtggatttt gtgtgaccag 19680

gctgttttat ttacacatat ttgcaaattt caaaattttc cttttattca cgacttccag 19740

tttagtctct atgctggtgt ttgtcaactt gttacaaatc tatgcatacc tacaaagttg 19800

gattctcaat tgaaaaaatg cttccatcac atgggcctgt aggaaatcct gtagggcatt 19860

ttattgattg gtggttgatg ttgaaggccc aaaatcaatg tgggtgatac cacccctaag 19920

ctggtggtcc tggaatacat aagaaagcaa gctgaaaaag ttatggggag caagtaagta 19980

agaagcaccc ctccatggcc tgtgcatcag ttctgcctcc aagatcctat tttgagttcc 20040

tgtcctgact tccctcagtg atggactgtg atttgaaagt ggaagacaaa tgtaccctgg 20100

gttataattg tgtccttcat ccagcccaaa cccattgctt cctgattcac caagatatca 20160

gaaaaaaatg tagcaatctc ttcccaacac acacacacaa aattagtttg ctttctattg 20220

ctgtgacaaa cccctataac taaaacctaa cttagaaaag gaaagggtta acccatctta 20280

cacaggtcac catctaccat tgagggaagt tagggcagaa tcttcaatca aaaaccatgt 20340

atgctatgta ttggcttgtt ttttaactca tgcttaacca acttcctagt acagcccaca 20400

aagcctgact agggaatgat gagcccacac tgagatgagt catccatatc aatcatcaat 20460

caagacattc cccaacagac aatcccacag aaaaaaacat gagctgggca atccctcaat 20520

tgagacttcc ttcctaaatg attctaaact gtgtcaaatt gaccattaaa gttgactacg 20580

aaaaaaaaaa tagagactct tcatctgcgc catgtttccc accatgatag gccacacctt 20640

caaactaggg accaaaataa ggccttccct caattgacta ctgtcaggta ttaaatcaaa 20700

gtaccaaaaa gatatttata tgggtctcta agtcccctct ctagtattaa caacaaacta 20760

tatcaacaac tgtctaaact atcagttgta gtaagaaagt gaaataactc tggattaaaa 20820

gtctctacag ttaacaagca ctaaatactt ccagaacaac tgctgtaatt actgttgaat 20880

atcaacctga caggatatag gatcatctat aacataaacc ctttggtata tctgtgagaa 20940

tgcttttaga ttggtataac tgaggtggga aatccctccc taagtgtggg cactactatt 21000

taatggcatt tgattttgta taccctttcc tgcttgtatc agaggagtta ggggaaaaac 21060

aaaggggtaa gtgacaaggg gaagaagggg tgtccttccc cacttgggta ccacagaact 21120

taatatccat caaagcctac ctgatcagtg gctttgagga tcttctttaa tgaatttgaa 21180

gaatattatt tgaggacccc agagggtgga ttatttgtct tgaattgggt acttgggtga 21240

ccagtgggtg ggcactttag agtgagaaag agacatagca gagctgggca aggtcagggc 21300

tttgggtgat aacattatga tctgaaggga ttttgacagg atttatggta attctgaggt 21360

gcttcatagt agtgaatgag agggattaaa actcaggctg acatccaatt tcaggtacaa 21420

caggactgaa tgggacatca tcgcagtatt attttaacaa accacccacc atgaatggca 21480

tggaaaaaag gctggcaagt gaattcttta tggttgccac cctctggctt ggagtattgc 21540

ccatgctgac ctctaattcc tggaaaaaca aaaacttaag aaaacaaaac tagtttccta 21600

ttttcaaata aaaattgaat gacttactta caagaaaatt ctccccattc taatatttta 21660

tgtgagagtt tgaaaagcgt ttttttcccc attttttatt aggtatttag ctcatttaca 21720

aaatttgtat attctttttt ttcttttttt tgtttttttt ccatttttta ttaggtattt 21780

atttcattta catttccaat gctataccaa aagtccccca tacccaccca cccactcccc 21840

ctttttggcc ctggcgttcc cctgtactgg ggcatataaa gtttgcaagt ccaatcggcc 21900

tctctttgca gtgatggccg actaggccat cttttgatac atatgcagct agagacaaga 21960

actccggggt actggttagt tcatattgtt gttccaccta tagggttgca gttcccttta 22020

gctccttggg tgctttctct agctcctcca ttgggggccc tgtggtccat tcaatagctg 22080

actgtgagca tccacttctg tgtttgctag gccctggcat agtctcacaa gagacaggta 22140

tatctgggtc ctttcagcaa aatcttgcta gtgtatgcaa tggtgtcagc gtttggaagc 22200

tgatcgtgag atggatctct ggatatggca atcactagat ggtccatcct tttgtcacac 22260

ttccaaattt tgtctctgta actccttcca tgggtgtttt gtttcctatt ctaagaaggg 22320

gcaaagtgtc cacactttgg tcttcgttct cttgagttta atgtgtttag caaattgtat 22380

cttatatctt gggtatccta aatttctggg ctaatatcca cttatcagtg agtacatatt 22440

gtgagagttc ctttgtgatt gggttagaaa agcgtttttt ttccctaggt ttattcatat 22500

taaatctttg gctgtaaatt ctcagcattt ttgccagtgg atttgaacaa ctttgtgtgc 22560

tgaactgttg aactgtgaat gaatgaatat gaatatgcag gaaacagatt tttgcctgac 22620

atcttaatca tttctcagcc acttaacaag gccaaattca tactgaaaaa caaaggctta 22680

ttggattatc tacattggga agatgaacaa agagatccag taacctaccc tcactcaccc 22740

ccttacacca ccccacccaa ccctaacgct accccaccct cattccctta ccactgctac 22800

cacatcacca cgccaccatt acccctatcc tcacccctgg taacaaaccc attgtcaggg 22860

tcctgacata aggttaaagt agcagttctg gtgaagctgt ggtcccaccc atacctgacc 22920

ccgcagagag tctattatcc taaaatgtga acttaaaagc tgtcaaactc tctcagggaa 22980

aaatttacct tctacctagt ctgggtttct ggatttgtct tctctcggga tgatatccct 23040

gaggaaattt cagacttttg agtcccatta tttggatatt ccagaaacta gagggaatgg 23100

tacaaagtcc ttacccctac ccccaaggct ggttaaagca tctctctata gaaaactatc 23160

atgggaggct taactctgtg tagaaactcg cagcaaaaaa caatgttttg tctaccctca 23220

aattatttcc atttaaatat ttattacagt attctcatta ttgttttaaa aataaaactg 23280

tggttatgta gtggaaacac tgccttaaca actattttaa gatttattgt atatgttagg 23340

tctcaaaact gacctggctg tcaggttctc tcaccatctc taagtcgtta cctgttacag 23400

ggtatggcca actccctaca caaaatttct ctagctgggc tgctcttccc tatataatgc 23460

atccattttg atcattcagc ccctttttgt ctagcctttt tccctcttga gctcttgatc 23520

tcctggcttt ccacttccca ctctcccctc tccctctgtt tacatgcccc tgctcaggga 23580

cctgttgact ctggactctc ccagatgtgc ctgcctctgc ttatgctctc ctgatatcta 23640

caataaacct atcatctata tctacaataa acctatctat catacctagg agtagtcacg 23700

tcctgatttt tattttttca ttcaatatat gcatataaaa tttatttcag tgcctcaaaa 23760

gacgatggag taaacatggc tttgtgactg gttttacatt tatatttagg aatatgtatg 23820

tatatacata tatgcatgca atataattca tttgaaatgg ggcatggact tgaaagagag 23880

caaggagggg tatatggaag ggtttagaga gaggaaatgg aggggcaatg atataattat 23940

attattatta tctcaaaaaa ataaaaagga gattttaaaa gtaatacaat attggaggtg 24000

gagtgaagaa ccctgttcat tccccagcac cctggtgggc agcacacaac cacctgcaaa 24060

tccaatgcct atggatccta caccctcttt cagacttcac acacacctgc aaaaagaaat 24120

aaatggccca cacataaaaa agaaattcaa ctttgaaaaa gtagtcccac attagaaaca 24180

tttttaaaca caccttcttc ctggaatcac tatgtcacct tttatctggt tttactgaag 24240

aactttcatc aatgcatcaa taacatttta ttaatgtcat aaaatgaata aacgccttga 24300

actctaggaa ggaaggaagg aaggaaggaa ggaaggaagg aaggaaagga gggagggagg 24360

gagggaggga gggagggaga gagagagaga gagagagaaa gagagagaga gagaaagaaa 24420

gagagagaga gaaagagaga gagagaaaga aagagagaga gagaaagaaa gaaagagaga 24480

gaaagagaga gagagaaaga aagagagaga gagaaagaaa gaaagaaaga aagaaagaaa 24540

gaaagaaaga aagaaagaaa gaaagaaaga aagacagaca gaccaaagca tatatttcag 24600

gaaggggaat gcaagtgcca attcagaggt cacagaggga aaaaagatca ttggtaataa 24660

atgaaaatga atgagttgtt atctggcctg gctgtatcca ttccactggt tagaaacaaa 24720

actgaatgtc accatagact gtaattgtaa caacccttca cttttggcat caatctcact 24780

gtaagaaatc cacattggga ataaatcaat tcaggaagtg tgagtccttg aagggaatac 24840

taggacccca gtatcatttt tcctctctct ctctctctct ctctctctct ctccctctct 24900

ctctctctct ctctctctct cctacacaca cacacacaca cacacacaca cacacacaca 24960

ctttcagtca tttatttatt gctagaacct cctgtagttc cctgtggcct ccactatgta 25020

actgagcatg accttgaagt cctgaattcc tgaccccttc ccctgcctat gcctctcata 25080

tactgagaag atggatgaga cacacacacc agaccttgac atttattatt attgttattg 25140

ttgttcaaag tctgactttt atgtaattta catgatttct ccttcaatag ttaaatagga 25200

aattactgat tccaattctc tatcattaat tcaattactt ggaagctaat gctaaacagc 25260

acatgatagg aatatatatt ttgtgcactt gtcagcatgc acctaacaaa aattgattac 25320

cctgtgtagt gatagctttt gtactggctg gttttgtggg tcaactggac acaagctgga 25380

gttatcacag agaaaggagc ttcagttgag gaaatgcctc catgagatcc agctgtggag 25440

cattttctca attagtgatc aagggggaag ggtcgcttgt gggtggtacc atccctgggc 25500

tggtagtctt gggttctata agagagcagg ctgagcaagc caggagaagc aagccaataa 25560

agaacatccc tccagggcct ctgcatcagc tcctgcttcc tgacctgctt gagttccagt 25620

cctgacttcc tttggtgatg aacagcagta tggaagtgta aactgaataa accctttcct 25680

ccccaacttg cttcttggtc atgatgactg tgcaggaata gaaaccctga ctaagacagc 25740

tttatagaga tcttggcata gaaactggaa ttttagaaga aaaaataagt ggaatgggtt 25800

aaagtttgac cttcaagtgt ggatttctgc ttcactctta tctcagcaaa gcaaacacct 25860

ggcagaacct tccagaagga gtgatgggca cagctacctg aaaagattct gtttgcttag 25920

aaaggaattg ttcctttatt gttccctgcc agcccagtcc tggaagcctt gataacaaat 25980

atttgtacat ttttattgtt ccccgcaaaa tcatcctctc ataactgcag atcctgtcaa 26040

catgcctgcc agatggcaga aatcacctat catgtgacct ataaaagctg tgagaaatta 26100

tggggtgttt gggaactttt caaagcatca gcccagtcat agctacaaaa tttcttgtgt 26160

ctcccagggc ctgctgggtt gattcgtggt tggagttttc catagcagca cacaagtgga 26220

aaatacattt tggtagaatc acctcattgg tgtcaattga tttcataaga aaaattaaca 26280

gtcacaataa gattgggtac tttcaaagtt ccctatgtcc aaatagtatc ccattgtact 26340

ctcagaacaa gtgaacattg caacctttat ttcaaaagat taatattcta attatgttta 26400

tatctattat atattgtatt atacacacac gtatgtacta tgagctttat ttttacactt 26460

ttattttagt attaattgtg tatatgtgtg tatatgcaat acatattata ttacacatat 26520

atatgtacat tacaattttt attttaaaat ttttcatttc agttatatgt atatgtggag 26580

tggggcaggg tgggcacatg tgagtatagt accatgagag gccagtagag ggtggtgagc 26640

ccccaggatc aggaacaaca ggtgtttgtg ggcttcctgt gtaggtgttg gaagctgaac 26700

ttggtcccta tttgttggcc ttgcttgtgg gggattacat gctacacttt gctggaggaa 26760

ttacatcagt gggggagagc tatttgagat tctgaaacat tcagcaagtt ctgtttggtt 26820

ggagatggga gctctcagct ccttgttggt gccaccttgc cagccccttc ctgctgtact 26880

tgtcccttat gtgtgcttct gtcacagcca tgcccacccc tcaccactat gcttccctgt 26940

gccaacgaac tcatcaccct ttggatctta aatgcataag tcaaaatatt tcttgcatac 27000

actcattttg tttgtgatat cttgtcacag caacagaaaa ctcttattgc ttaacactaa 27060

gctacctctc cagcccctag aggtttttgg tttggtttgg cttttaatat catttttttt 27120

ttatttatgt gtaggggtgt gtgcctgtgt gagttttccc catttaattt atttatttat 27180

tcattttaca tgcccccctc cttgtcccca ctcacatcgt ctcttcccca ttccccctcc 27240

ccttctcttc tgaggcccct ctgggtattc cccgatcctg gcacatcaag tctcttcaga 27300

gctaggtgca tccactccct ctgaggcaag acaagcagct cagttagggg aacaggttcc 27360

acgaagattt gagagaagga atgaaggccc taaaggggat agaactccac aagaagacca 27420

acagagtcaa ataatctgga ccccgagagg ctctcagaga ctgaaccacc aaccaaagat 27480

cctacatgag ctggacctag ccctccccac ccccaccccc cacatatgta gtagatattc 27540

aattcggact tccaatagga gctgtcccta aagctgttgc ctgtctgtgg aatctgagag 27600

attagttttt tgttttttgt ttgtttggtt ggttggttgg ttgttttggg ttttttggga 27660

ggattggggg gctgtttgtt tttgtttttg taccctgaaa gttcttcaat ggaatagttc 27720

tcagtgttgc ttctatttca ttcatgctac ccacaggctt gcttttgaaa ttacatgtat 27780

ttttcccatt ttcttctctc taaatttgag tcaatttctg gtatcagcat gtttgaaaca 27840

ccaagcagaa taatgtgtct gctttatttt atattttgtc gtacttatgc acatggaaac 27900

acacacacat gttatgtgct caattattgg aacaaatgtt ttcctttttt atctactctc 27960

actatgtgac cctttatttg tttcaagtaa ataaaataac aaactgataa tcaaactaat 28020

aaaactgtaa catttacaga tgatgtcatt atttgcatca tctaattctc atggaaaagg 28080

tgcccttttt cttactaatg ctacttacag gtagacactc ttagccaaaa ataatccgga 28140

agtgaaactg cctgccaaca caaaccactg atgactgata agattcctga ggattaggaa 28200

aaccacacgg ttcttacagg gaacaactga ttcttcagag actgcctaag aaaacactga 28260

cacatttgca gaaaagctat tgagttggat aaaagtttta caaaatgccc acaatgaatt 28320

ttaatactaa acctgcaaaa gaaatatgct aaggaaatca cacacacaca cacacacaca 28380

cacacacact accaccacca ccaccaccac caccaccacc accaccacca ccacacaaat 28440

aaatgcataa gccaagtcct gagggcctgg gatatcagcc ccaaattcag taggctgggt 28500

aagaaggaag ccaggactct gttttaagat gaatttcttt caaaatccac aggaacacat 28560

catgcatatc acatcatgtg ctatatcctg gccctggggt tgtggagtgt ccaagaagga 28620

tgcggaggca caggttatga ttaattatct gagcatatca agcagcaaac tcagacactc 28680

cttcctcttc tgtcttccaa aggatgtttg tttcgggaca ttttctagaa agacaggtac 28740

caatgtatat tgacagatga ggcacaccaa tgatagtcaa aggaaatttt tcacatgagt 28800

ctttctgggt tgacttacag gagggtgttt tccaccatca catatggaat gtttcacttt 28860

ctgccatttc acatcagtaa atataaatat tgatgagtgg gcgtccttcc ttcaagacat 28920

gcatttaatt gggttttgat caaatgttca ggcactggga ggaagccagt ggcatcaaag 28980

ttgtccacaa acccaacatc acactagggg actagtgtga aaactcagta aaagttgccc 29040

aagtcatgta tctgttgttg ttgttgttgt tgttgttgtt gttgttgttg tcatcgtcat 29100

ctttggaggt ggtggtttgg tttggtttgg gagtgtttgt ttattttgtt tgagacagag 29160

tctcacttca tagctctgac tgatctggaa ctcactatgt agaccacact gaccctgaat 29220

ttggagagat cctgcctgcc tctgcctcct gagagctggg attaaaggca tgcaccactg 29280

tgacatgcaa gttaattttt tttaattata ttttttctac aactaacatt catcagtgtt 29340

tcagcctgga aggaagaaaa cttgcatgca atcaatgttt taattgaaca agaacatatg 29400

caaatggcac aggcatttct atcatttgga tttagaagaa aatcccaaga tgatgttgca 29460

gttttcccac ctcagctgtg aacacttact attcgtgatt gagtctgcag gcagttggcg 29520

ggcaaaagcc tgtcaggggt attattagcc ttcataccag atcataaaga aggatttgcc 29580

aaaaatccta gtttccagaa gagctctgtt gtaccaaggc agtggagcat cgccacctta 29640

cgactgtacc ttgcaatgca actagctcgc acaaattaca aatgctattt attgattggg 29700

gcagggaggg gaaaaaaggg gagggcagag gcagactgtt ggttggtttg gttgggttgg 29760

ttggttggtt tgttggttgg tgatttttca agacaggatt tctctaacag tcttcgctga 29820

cctgaactcc ttctgtacag cagtctagcc tcaaattcac agagatccac ctgcctctga 29880

ttctccagtg ctgggctcaa aggcaagcgc cactactgcc tagcctgtgt tgttttttgg 29940

ttaagcaaaa catctttaaa tgtctagatt agatatccag attaaatgtc tagactaaga 30000

tctctaaaca ttttctaata taaattttat cagttgaaac ttgtccactt ttatgggatg 30060

ctaaggatgt atggaactca ggactttgtg cattcagtcc cactgtctgg tagacactgt 30120

tatgctgtat attcctaatg gggagcagcc aaaaacaaaa acaaaacaaa caaaaaatcc 30180

aaacctcaat tccttaatta attaattaat taatttttta gaactaagat ttaatcagga 30240

aagttgcatt atatgcatac ccctggttat tcaggtaagc atagtaagaa tataattaaa 30300

agttgtctgc acatttgaat ttagatggat atgaaagtgt ttcagatttc ctacttaagt 30360

aaagtgaaac aatattgaaa tttttcgaag gttgttactg tgggatcccg ggtccacaga 30420

cacataaaat aaatctttga aaaaataata ttaatattta gtaatgtgac atgaaattaa 30480

attaaaccaa tgtttttcct ctggcaagaa acgcagaaag taaaaatgat acattgtatt 30540

cgtggtaaaa atcctaatct catttaatcg atacacattg catccattat gagttgcagt 30600

cattaataat aaaataatat tattaagcag caagcaaata gtcttaaagc agcacgtagt 30660

gagacctcag agctgttaat ttcctaataa aagaatacac ttcccaggaa actttacggc 30720

caggccaagc acttccggaa ggagggacta cgggacggca ataggaccct tctgtaagaa 30780

aagggagaaa tgtggcttca aaagaaacca tacttattca tgtgagtggc gatttgtcac 30840

atgtgtgtga cgatagccaa tatgtctgaa gagaaagacc ggttgtggcg ctaactgggg 30900

ggacctactg cctccctgta agccttcctt acaaggctat ctcggcgcaa ggaatgctgg 30960

aaagtgtagt gatttggctg gaaactacca gctattaagt aaaatcgcgt catcaccccg 31020

accagttctg ttcccaagcc tgctgatcta gaccttatcc cacctccgtt cctgctccat 31080

tctgagccct gactgtgaag gtttcactct cttcacttac aggagcttta gggaagaagt 31140

ctcccacagg agctgagggt ggggggcggg cggtctccct cttctggcct ctatcggtac 31200

tgcaaggagg ggccaccaat tacatgcaat ttttatgcca cactaagatg cacaaataaa 31260

taaggccaga gattccccag agtcaggatt tgaggctttg gggaccaatg agagttgttg 31320

gattgaatgc aaaatgtaca cacttggaaa caagactggg caaggctgca ttttctagtc 31380

tgcagggaga cctgaaaagt tagtagaagt acatgtgtgt gtcagttcta aatgaaacga 31440

cgggggacaa atgcctgagg tgcctgttag cataccaaag cacatgatgg cctctagact 31500

cacttgggac cgctgactat gctctactct tctgatctgg ccccataact taatccaagc 31560

cagaccttct cctagcatct tttacctata taaccagcca tttaggccat gctcccactt 31620

ggtcctctca gtctcctctg ttccctctct tttcttcttc tcttattctc ctcacccttt 31680

ccacctctgt cctctcatgg ctgggttcag tctactgtcc aggtttagtc cactactttc 31740

tctgctctgg actcttccag aagcctctgg ctgttcttat ccgtacctgg gagtggccat 31800

accctcattt gtacagtatc ttcctccagc gtctccctgt ggctgaccct ggaggccttt 31860

atgctttctc cctggaaaaa ttctaattgg gggggggggg ggaatccagt ttgttgcaat 31920

gaccagacag ctgaaggggt ggctcaaggg ccggggcata ggtcattgaa atatactcag 31980

ggctactagg agtggcagtc agtgttcaag tacacaggaa gcaactttct ctgcaaaggt 32040

ataaagaaaa gtaaaaagtt ttgaaaaagc taaaaattta aattaaatta aagacaatca 32100

tctgggcagt gatggtgcat gccttaaaaa ccagcagatt agggctggag agatggctca 32160

gcgattgaga gcactgactg ctcttccaga ggtcctgagt tcaattccca gcaaccacaa 32220

gatggctcac aaccatctgt aatgggatcc agtgccctct tctagtgtgt ctaaggacgg 32280

ctacagtgta ctcacataca ttaagtaaat aaatagattt aaaaaaaaaa ccagcagatt 32340

atacatggga gacagaggca ggtgaatctc tgagttcgag gccagcctgg cctacagaga 32400

aagttccagg acagcaaagg ctatacagag aaaccctgtc ttgaaaaact aataaattaa 32460

attaagagga caacaaaggt gagctgagtg ctttctgggc cagtgagtcc aggtcctctt 32520

accctctgaa ccacatctcc agtcccaaat taacctttag tttctactcc ccaggaacat 32580

aaaacaagcc ctggacctta taaaaggtgt caggagataa gagcagccta aggcttcttt 32640

atttctttcc tctacactcc tggaaaagaa agggtagcag gaaagccagt ggtcagataa 32700

aatacaaatt gtcagattaa aatcttaatt ctggttgtat ttattttaca ctctctgagg 32760

actcattgcc ctacagtatg tttggggact agaaaggaaa tgaaatctca gtgtcagtag 32820

cccacaaaga gacagaagca aaagtagttt gcaaaggaca gtgagaaagt cctctgatgt 32880

tctctccctc tccctttcct tctaccctct tctttctgca tttttttttg acccagctcc 32940

tgtgaccccc atctccaacc ctttgatcca gtaggacttt caagttttct gaacagtgct 33000

caaagaaaac actttacttg tggttttcca tatcctctga ggtctggact ttctgtcccc 33060

agccagcagg tggtgctgtt actacagctg gaagcaaagt tcccaaaacg tagctgaaca 33120

cctgggaggc tgattgactg gtagtgtgtg gagatgtgca gagttggaat cctgagagtc 33180

cagagcctaa ttatgatttc tcttggacaa ttttcagctc tctagataga tgtccctaag 33240

ccacctatgt cagacctgac gtcctgtgac taacagattt aaaaaacaaa caaaaataaa 33300

acattttttt ttgtctgtct aatttgatca aattgttctt tcacagcaaa gggcctagta 33360

aaagcaagga cttctggctc tgcttcatcc acctggctta atattcccac tcatgtattt 33420

tgaaaagaac cttgattgat gttcctataa aaacttcatg aaactgtgtc tatgtccctc 33480

catgggattt ggggatgcag tttaccatgc cttaccgcaa cctgatgtgt ggaaccttca 33540

aactgtggct taaaacaaac tcttctttcc tttaaagtgc ttgactcaag tattttgtcg 33600

aagcaatgtg tagggtaact aatacccttg gatagattaa atcagtggaa atacactctc 33660

tgtcactgga tgagaacgtg cttttagcaa ggctcaatgg catctttcat cctacccagc 33720

acttaggaag cagaggcaag ggaatctctg agctcctggc ctgcctgatc tacataaagg 33780

atttcagtcc ctgtgacact tactcaataa cagtgacagg agagaatttg gttcccagga 33840

acttggagat gggggcggga tattggagag gttgggggag gatgttggac agctggctac 33900

catgtgagtt ccaaatttag gtggacagtg atagaggggg gtattccatg ccccctctac 33960

atttccatat gtgcacatat gtgcttatct aaatgagtca ttttattact ctttgattcc 34020

catttcccaa tttccttcta tcaagagagt aaagacaaaa aacaaatcca ttattttttt 34080

tgtgtgtaaa ttcttctgct catgaatatt ctatgtattt tagttcccta aaaacaaaac 34140

ttcattaaaa attttgaaag ctgcccataa tttttttgac atagaggaat tcaagttata 34200

cattcaattt tacattttga ttgcatttta aagcatggga ctactgcagc tcaaagcagc 34260

tgcaaatctc aaaccttcct gcctccactt cccaggcact gtttacaggc atggagctcc 34320

attattggat atagaaacac acaaagagaa acatacacac agacatacat acacacatat 34380

aaaataggct ttgctggaag aaaataaaca agaacaaaac agtgattatt cagtttggtc 34440

aggcccaagt tccaaggcta tacacatctg tgacaagaat ttcagatata aacatgtgaa 34500

ggaaatttta taggtgcacc ttttttattt atttttgtta gatattttct ttatatacat 34560

ttcaaaagct atcccgaaag ttccctatac cctccctcca ccctgctccc ctactcaccc 34620

actcccactt cttggccctg gcatttccct gtactgggac atataaagtt tgcaatacca 34680

aggggcctct ctttccagtg atgaccaact aggccatctt ctgctacata tgcagctaga 34740

gatatgagct ctggggacac tggttagctc atattgttgt tccacctata gggttgcaga 34800

ccccttcagc tccttgggtg ttttctctag cttctccttt gggggccctg tgttccatct 34860

tatgactgtg agcatccact tctgtatttg ccaggcactg gcatagcctc gtacaagaca 34920

gctataacag gggctcttca gcaaaacttt cctggcatat gcaatagtgt ctgggtttgg 34980

tggctgatta tgggatggat ccctgagtgg ggtagtcact ggatcctttc gtcttagctc 35040

caaactttgt ctctgtaact cctttcatgg gtattttgtt ccctattcta aggaggaatg 35100

aagtatcttc cctcttcttg attttcttgt gttttgcaaa ttgtatcttg ggtgttctat 35160

gtttctggac taatatccac ttatcagtga gtgcatatca aatgacttct tttgtgattg 35220

ggttacctca ctgtcttagt cagggtttct attcctgcac aataatcatg accaagaagc 35280

acctggggag gaaagggttt attcagctta cacttccaca ttgctgttta tcaccaaagg 35340

aagtcaggac tggaactcaa acaggtcaga aagcaggagc tgatgcagag gccatggagg 35400

gatgttcttt actggcttgc ttcccctggc ttgctcagcc tgctctctta tagaaccaag 35460

actaccagcc cagagacggt cctactcaca aggggccttt cccccttgat cattaattga 35520

gaaaatgcag aaaatcaaga atttcacaca caactatgac aggcatttca tacacataca 35580

catatgacaa gaatttctct ctctctctct ctctctctct ctctctctct ctctctctct 35640

cacacacaca cacacacaca cacacacaca cacacacact cctgtgacaa gaataccata 35700

cataaaactc tggtaggaat ttcacataca aacctgtgac aggaatttca catacacaca 35760

tacccacaga catctgttaa atgaatttta aacacacatg tgaccagaat ttcacacaca 35820

cacacacaca cacaatcacc tgatacagga gtttcactca tacaactgtg acatgaattt 35880

tatatacaca cgtatctgtg aaatgaattt tacacaggta catgtgacag gaatttcaca 35940

cacacacctg atataaaagt ttcacacata tacatgtgac atgaatttca catacacgca 36000

tatcagtgaa attaattttg cacacacaca tgtgacagga atttcacaca tacacatacc 36060

tatgacaaga gtttcacaca caacactgca ataggaaatt taacacccat acaaaacagt 36120

gatatggatt ttatacacac acacacacac atacacatgt aacaaaaaat tcacacacaa 36180

aactgcaaca ggactttcac acacacacaa agctgtgacc agggttcaca cacacacaca 36240

cacacacaca cacacacaca cacacacatc tgtgaaatga atgctacaca catgcctgtt 36300

accagaaatt cacatgcaca cacatacaca catacctgtg atgggaattt cacacacact 36360

gtgacaggaa tttcacacat atgcacaaac tcctatttca ggagtttcac acacacacct 36420

gtgacacaaa tttcacacac atacacacac acacacacac acacacacac acacacacac 36480

acacactgtg atagggttgt taataagtag ctagctagat ggatagttga atgatgggtg 36540

ggtgggtgtc tgtactgatg gaaagatacc cagaggtgat gaattgacat ccagaggtgg 36600

acatatggat ggaaagagga aggcatgaat actgaacaaa tggaagcatt ggtgaatgga 36660

tgggtgtatg aatggatttg tcgtgcatgt actggtagag ggtctaatga gtgtatatat 36720

gagtgggtgg ctggctggct ggctgaatga gtgagtggat ggatgggtgt ttgggaggat 36780

tgttaaagtt ccttttgttc tcctgatata actattgttt taaaggctta ttgcctccat 36840

ctgctaacct aagcctagtc ttggaagctt ctagcctcca tacaatctta tctaggccta 36900

gaatcttttc aacatttgag acttgctgct gaatatgctc accttttcta gttatttctg 36960

aactcctgct agctggtcaa ttcagcagtt ctggctcaga actcttttcc atgctaactg 37020

attcaatctt gcttctcttg gcttctcttg aatttctcta cttggcctca taataacttt 37080

ggcaatatgt tctatacaga agtatatggc tccttctcat tctctgactc attctgtctt 37140

ctcctgtgtc ttgcttggtc tctctctctc tctctgcaat ctgcctctgt acaactgtcc 37200

cagtaaaact gcctccttcc tcccccctcc actctctgca ctgctctctt aagtagcttc 37260

cctttcttct ctcttcttat aggatatgtt acttcctcct acaaactaac tttaccttca 37320

ttgtttggga ttaagggtgt ataccaaggg catgtctata ttccagcaag ggggattaag 37380

ggtgtgtgct aagggtgagc cacaccacaa ctagaaacag gtttttccag taaataattc 37440

aatcttgggt ttcccagtgt gatcaaatat cctacaacag tgaatggata gtaagatggg 37500

tggatggatt ggtggattgt gagtagatag atgaataggt gaatggatgg ataggtggtt 37560

ggataggtgg gtgggtgaat gaacaggtca tgtattgtgg atgtgtggat atatgagagg 37620

gtggatagat agatggatgg atgggtgggt ggatggatgg atggatggat aggtggatat 37680

atgtgtgagt aaatgaatgg gtgggtggat gaatggatag gtggatatat tggtggatgt 37740

gtggattagt ggtagatggg tatgtggaca catggataaa tggatggatg gatggatgga 37800

tggatggatg gatatgtaga tggatgtata aatggatgga taggtggatg gattgatgga 37860

tgtgtaggtg tcagtaaatg gatggataaa tgtataggat gatgaatgaa gggtaaacgg 37920

atgtgtgggt gggtggataa ataggtgtgt gtgtgtgtgt gtatgtgtgt gtgtgtgtgt 37980

gtgtgtaggt gtttggatgg atggtggatg gatggtttag tggattggtt gattgtgaat 38040

atgtgagtga attgatgact agatgggaat attgaagttt gaataaatgg atggatgggt 38100

ttatggatga atggatggat aagtatatgt atggatatat atatgtgtga gtgggtggat 38160

ggatgaatgg atgagtgaat gggtgagtgg atggatggat ggatggatgg atggatggat 38220

ggatggatag gtggatgagt tggtagatat gtggatgtgt gagtggatgg atgaatagat 38280

ggatagtgaa tggatggtgt agtggctatt cctggttgtc aacttgacaa tatttggaat 38340

gaactacaat ccggaattgg aaggctcacc agtgaccctt atctggaggc ttggagatcc 38400

ttatctggat cttggtttga agatcttgag ccatagtggc tatggattcc agaagattga 38460

atctccgagt ttaaggaaca cacccttaat ctgggctacg cctttcatct gggattaaag 38520

gtgtggtgga acacaccttt aatctgggct ccaccttctg ctggagacaa tataaggaca 38580

ttggaagaag ggagtctagc tcttgctctt gctcctttgc ctgcttgctg cgtgagactg 38640

agtaactgct agatccttgg acttccattc acagctgcga ctgaacaatt gttgggaatt 38700

cggctgccga ctgtaagtca tcaataaatt cctttactat ttagagatta tccataagtt 38760

ctgtgactct agagaaccct gactaataca gatggataag tagatggatt gatggatgga 38820

tgtttgagtg ggtgggtgta tgtatgggtg ggtgggtgga tggatagaag aatgggtgta 38880

ctgatggaga atatgttcat caatgttgct ttgtaacaac ccaattgtaa gcttctattc 38940

aacaatgtac tgctttcttt gttcccaagg tcatgcctta tctgtgatgt tcaaaatgaa 39000

ttcacagcca gatcttaact tcccatggcc gactgtgagc accaaggatc ttaaatcact 39060

gacaccacat tccttgaacc ttgaccctga aacatcctgg tatggatgtg acatcagctc 39120

agctgcaatc aggactatat gagagggaac tgagaatgtt catttgtaga gcagagagac 39180

aatctctaca cagcccacat gaagaagaaa gtggagaaag gggaggcaga aaggaaaagg 39240

gaagagggat ggactgaatg aagggaaggg aaaagatcag tagggagact acctccagag 39300

gtggttcaac tacagaagca cagcacagaa gtctctgctt caaaaataga attgtttgca 39360

aactcgttcc tctttctcat ttctccaaaa gaagggaggg gctggaatca cacccatggt 39420

ttaatgctaa ccaggaacaa tggagtagat gctgctaaaa gtgaaggacc tgctacaact 39480

tctgagaaac tacaaagtca caatcaagta ccctaagctt ggcctggatc acagggtgct 39540

tctagaagtg tgactcttct aaaagattct acttcataca aggccgtgac ttttcaaatt 39600

cacctttaat ttgaagggct ggttttatgt atttatcatt gtcagttctt tatccattta 39660

cttaattttt tgttgtgttt atttctggtt tttcaagaca gggtttctct ttgtgtagcc 39720

ctgcctatct tggaacacac tctgtagaac aggctggcct cccactgaaa gatcagcctc 39780

ccaagttctt gtcttacagg attaaaggca tgcaccacca ctgactggtt atttaaatat 39840

ttttaagatt ttttaaaatt gtatatagtt ttttcccata atcactgtgg gaggtacatg 39900

gggttcagat tttggataac acattacaaa atctaccaca ggaggatact ccctttgagg 39960

aggcagatgt tttctaaaga aaagtattta tttctgtcgc ccactgtcca gtcagactca 40020

tttaaagagg aatcaattga caagaaaact aactgtgcag gggtctggcc agaagagggt 40080

cacttggaag gttctgtgaa aggctgagtc aacaacagga agttgatctg tgtggtttga 40140

gatagcatct ggcctggcct catagcagtg acaaacattt cctcaaaaaa gatactgtga 40200

gaatgagtta ggttgagtga gaaagctaat accaaaactc acctattatg atttattctg 40260

taagagtaaa catgttttta ataaggaaaa aataaaaaag ttgtggagaa caaaaaacaa 40320

cccagcacta actaaacata tttcctgatt ttaacattca caattttggg gccagctagg 40380

tggcttagga ggtaagagtg tttgtgacca agcctgggaa tcagagttca attctgttgt 40440

cccatccaga agctgacttt gatttttact tttatgtatt gttatggcat gactgtcaga 40500

ggacagcttc attgccatca gctctgtctg tccagctttc catggcttct gaaaattgaa 40560

ttcatgtttc caggcttgag tatagtctta ggatatctaa tattgaaact ttttcttttt 40620

ttttttcact aaaaaagtga atttagcttg tgactatgtc ctcgcacttt cgagtgtgtt 40680

gagtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtacaccttt tctcgctgta 40740

tcaagaatct aaataatttt ggcattttct gccacccact gtaaggatca caccaaggtg 40800

aggaatttct cctcttccaa tccaagcaca catttctgca attttatcaa aactgtttat 40860

cattattgga ctgaagttca tcaaacttca cctcctattc ccctcatctg agcagaagca 40920

atgtgcattt ttccttattg tgtttgtttg tttgtttgtt tatattttgg attttcgaga 40980

cagggtttct ctgtgtagca ctggatagtc tcaaacttgt agaccaggct agccttgaac 41040

tcacagagat ctacatgtct ctgcctcctg ggtgttattt tctttagatt ctgcaatatt 41100

attgtaaaca cttcccaggt agggaactca aacttaaaaa ttcgtttaca atttcctcat 41160

aatacacacc tataccctca gtagaatttc atgtagtgtt ctttggggat ttgggtggtt 41220

tgctttgttt tatttttctg tcaagagaca aggtctcacc atgcagcctt ggctggccta 41280

gaatttacag aaatccctct gtctcagttt ccttagtgct ggcctcacag gcatgcaata 41340

tgcacctttt agcaagtttt taagtgaggg tctgtaaagt ttcccaagtt tacttagttt 41400

atagtccttg accctggcct gcagccacca agtagtcacc tgaaagaaaa gaaaatagaa 41460

tttgcagcta tttttcatga gaaaccaagg tggtatctgc agagatggag actgagtcat 41520

gaaaaggaga tagagttgcc acagagaagg ttgctgccca agggaaactt actctgctga 41580

gctccatgct gtgaccctga aaactagagt ttcacagatg atctgagact aggggatatg 41640

ttcgagtgtc ttcaaggatt gtcccaagtg aatccatagt aaagcaggga taatccatgg 41700

atctaaaagg aaacaacagg tgcccatcca gtcatgaaat agttaatatc cagacttgta 41760

aaagcaggaa gttcctagac actaaacgaa tgaatgaatg aatgaatgaa tataataaaa 41820

gtatgtatgg ggctagagag acagcttggc aattacaagt acaacctacc tttgcagcca 41880

acccaaattc agttcccagc acccacaagg aggcttataa attccacaac ttcagcatcc 41940

agatctccat ggtcaatgac ttctgacttt tagaaaacag atccaacttc cagtgacata 42000

aactctgaag ctttaacctt cctggctgtt ttgttttcca ctagaacctg tgactgaagc 42060

cctactacaa cacaaccccc accatacata catacacaca cacacacaca cacacacaca 42120

cacacacaca cacacgtaac ttgatccctg actgaaagca agttcttact ttcaccagag 42180

tacttgagct ccacccacct cctcgtcaat cacttaactg accacaagaa aatccaaatg 42240

ctttgttgac aagatgcatc tatggacact acaacaaacc cacaaaccct tcttaaacat 42300

agtttttaag tctacagaag attcgtatct cacctttccg aggctatttg gagctaggct 42360

atactcacta ggtagtgctt acagctcagt ggcaaaaatg cttatagcta ctaggataag 42420

gtgttcaata gctcagtgga tagggtgctt gaagattagt gagtaatgtg cttgtagctc 42480

agtgtcttag ttagtgttct attgctgcag taaaacacca agaagcaagt tgtggaggaa 42540

agggcttatt cgtcttacac tttcacactg ctgctcatca ccaaaagaag tcagcactgg 42600

aacacacagg gcaggagcct agaggcagga actgatgcag aggccaaaga aagatgctgt 42660

gcactggatt gcttcctctg gtttgcttag catgctttct tatagaaccc aaggctacct 42720

gggccctccc cctcttgatc actaattgag aaaatgcctt acagctggat ctcatggagg 42780

cattgcctca actgaagctc ctttctctgt gatatctcta gcttgtgtca agttgacaca 42840

caaaaccagc tagtatgctc agtttgtagg gtgcatacct agcatgcagg gagtcatcag 42900

ttcagttctc ttagctttgt gggtccaagg actgaactca ggccattagg catgatgcaa 42960

gtgcctttac agacccagcc atcagacccg atgtttttaa tgctttcaga tagcacccag 43020

gtgggtgtac tagcacacat ctggaatctt aagaatcttc agcctcactt aagaagctga 43080

ggctgaagaa ctcctgcatt tgacatcagc ctcactgatg tagcttgtgt ttcgatttct 43140

tgcctgttgc tgtgacaaac tccctgacca acagcaaaag aacatgactt ttatttgaaa 43200

acaagaaccc tctgaagctc acttgcaatg tcactgccaa atatagaaac tgaacaaagg 43260

gtagaaagca gcagcatttt cccgaaaatc actgataggg aagagaaacc catccaccca 43320

tgaggagaaa aggggccact catgagtcac tcagaatctg gaagggactg aaagaaccct 43380

ccctggggcc tgacaaggaa gcctcataca ttgtgtgcta cctaagagtg cctgcaccat 43440

cttgtagcac acctgctctg tgccattttg gatcccaccc ttagattcaa cccaacctgc 43500

accatcttag atctgatcca ccctgggtca tcttggatgt cattcactct gggccatcct 43560

gggtctaata ctctaccaaa caagctccca gtgctctacc ctctgagcta gaagaactct 43620

actcaatgag tcacaaatac tcaactacaa gcactctacc tactgagccc catccctagc 43680

cccatatcca acctttgact gcccatgttt cctttcattt atttttctgt atttctacct 43740

gttaggagca gattccttgc caccatgaat cctttgtgct gtgtctgagg cagtttcact 43800

tcagttatca gtgacagttg gtttttaaca aaccagctct gcctgtcaga gtttgaggtg 43860

ccaataaata atgcacaggg tcatgacctt ttttcaggcc aaagcacatg ctgctttcag 43920

gtgcatgtgc aagtgctgtg acccccccca gctccaccct ctgaggccct gaagccatgt 43980

gatcagcaat catcaagccc atgatgtcag cagagcaccc aattcaagag gcctgagtcc 44040

acaagattgt ggggactaag tgatggctat gtgggaacaa aacaagactg cagagagcaa 44100

agcatgaaaa aagagaccca ctatgtgatg agggggagga gaaatcacag tcacagtgga 44160

gcagccctag atactgagtc tgcagcactc cctgggtgct ctgcctgaca tcaccctggg 44220

tttctggagg atgatacctg ttagggcaat ggcagaccct agggtgagtg gtaatgtgca 44280

catgcagaag aaggtgggca gaggagcaca ctggaacaat tctggccatc ctcctgcctt 44340

aggcacatgt atatatgctt catgtgggct tagagattcg aactcagatc ctaattgcta 44400

gagcacccat tctcatagag tatctgtctc atcagaagat caatgtttgc agagttgaat 44460

aaatgctttt tgttgttgag atgtttacca aagactgcat ggacatgggt ttgaggcaat 44520

agaaattctt tattagccag ccagagacta catttgggta cttgggttcc aagtgtaccc 44580

taagcctttc tcagggtgag cttttaaaac agaaactatg ttctaggttg acatgtttta 44640

acaagaacaa ttagccagaa gtggaactac agaaaccaaa atgcaagctt agtagattta 44700

gaaactttcc cagaactaag ggctttgatg gactagtctt ttagttttgg taggtggcgc 44760

tgtcttcatt ttgagtgtta taacctgaat gatacttcca tcatggagtc agctgtataa 44820

agtctggggg tctactaagg tctgggatca ggctacagtt ttgtcatagt gtaaccaaac 44880

tcaaaataat agcaggctct gtgcattctg actagtggag tatcaggtcc tagcatgtgt 44940

ttattgaatg agaaaatgtt ctcaatgtga aacaataaaa aaaaataata ataaataaag 45000

cagccagcag actttcttgt tgccaaggtc agtgtacttg ccacctacgg gcatcatcgg 45060

ggcaactggt tccgaatgga tggtccccac ttcattcctg acttggggcc ctattggccc 45120

tgtgtcttct aggacccagt gcctcaaagc taggagcggt gcagtgcagt gagcatgcac 45180

tgagcagccg ggagaccaca ttctttgcat tccaggctca gggaaacacc gccctcacct 45240

tgcaggtggt ggctgcggtc tgtgaagcac ccagttctca gcactgccta cgagcccagg 45300

cctgtttgaa gccgcataac aagtccctgg aaacccggtc tactcaggag ccccagggct 45360

caggatcagc aggtgctgca gggccactga gagcccgggc tttcgggagg gcggcactcg 45420

gggactacag aacaccagga gttcaatccc ctgagattaa ggagaaaccg agaaaccctg 45480

cccaacccgg actccttctg gtgcctttac ccactgctaa ggctctgctg gtaaatatcc 45540

aagcagcagc cggaagttcc tgcacctctt ccttcccgct tcctgccaag ggggaggaac 45600

caggcatgcg gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 45660

gagagagaga gagagagaga gagagagaga cccatggtgt gcgtgcgtgt gtgtgtgtca 45720

agctggaccc cgtggcccca gtgcagcccc ctccattact tttactttgg tgcaggtaca 45780

tcccatgggc gtgggccccg cgggtgagta acaataggca gggttgggcc aacgccgggc 45840

tcctccccgt cggttacgca acaaggcgga gcgagatgaa ggctcttccc cctcgcgtca 45900

tccagacacc ccactccccc gccgtcacaa gccggtcgcc gcccagccgg cttccgccgg 45960

gaatgaagag ggttgcggtt ggctccggtc ccgcggaccc cacgcgcgtc cgtggagccc 46020

tcgggcgact tccatgagcc cctcccatcg ctctgagacc cgctgagttt gcttccattg 46080

tcctctcggc cgcgggctcc ggaacacccg tgcgagccca ctgctgatgc acagactgcc 46140

attgcgccgc tgtcacaccg tgcgtccccc gccccatgga gccgcccgct ggtgccgcgg 46200

cgaccgtaaa agatccagac catgaccccg tgaagaccaa ggtctcggcg cccgccgcgg 46260

accccaaacc caggacatcg tcacagaagg cggggcactc gttacaagat tgggacacca 46320

tagccaccgt gggtgagtga gaactgagta agaacttatg tgtggggacg cggcttggga 46380

gcgaccctca gatttctgtc tcccacactc tcattactgg gcctccggaa acggggcagc 46440

cccacgtcac agagctttca ggagggtgac ttcaccttag ggactcggag gctccctact 46500

ggggtgctag ccacccttgg gacaccacgc ccggcctccc tggcgcttgc gcacccgctc 46560

atgcccagga tttctcggga tcgcatccag cctccgcact gtagacccct ggcgggactc 46620

gaagggacgc gtgaccccca agggaccctt cggggacgtt ttcccagcat ctattgtgtg 46680

cctgggtctc gttttttctt tagtggctca aacttggtac cctcgtgacc ccgaaagttg 46740

ctagggaagc cggtagatcc ccaaacgtgc cggagtactg gggagggagg ctaggatctt 46800

gcgaatcatg ggcgccagct tctcaagtct gaagcccagg agtcccgggc ttctcagcaa 46860

acttggtcac taggacagtt gtgcctggtg tgttgatgat taggaaagtg ttccgggagg 46920

atggaggaag gacagaggga gggattggcg tcctccgatc agctgtgagc agagattcta 46980

gaggcttctg tgttcaccct ggtgtggaag tcaagtcagg gttcaggacc aggatgaggg 47040

gcaataaaca ctttctcagc tgagcaggtg agatgttaaa aaaaaaatgt gtgtgggtaa 47100

aagggcttgc aagtttgatc ctggttccct cttggaggct ggctgacact cgctgcatct 47160

tggcttttga ttgacttttg agggaaactg agctgcttga atgaatgtcg tttatttatg 47220

tatcatgttg tattctaggc tggcctttcc atcactgtgt agccaggatg accttaaact 47280

acacattctc cgcctccccc tctttctgag tgctgggaac cgagccccac tccaccacag 47340

attggttatg gggtgctggg aatggggact gccctctata tgtttgagac attgacctga 47400

aagtcactgc atagcctaag ctgactggag atgccagaca atcctcctgt cttagctttc 47460

ccagtgctga gacttcaggg actcattcac aggcacttgg cacctcaact ggttctccac 47520

ccttttcttt ctgtctgtct tccttgccct ctccctccac gccccatctc ggcaccttag 47580

ctggttcttc tctccttcct tccttttttc tttccttctt cttcgtcctt ttttgtgttt 47640

gtttgtttgt ttgtctgttt gtttgttttt gaaaacaagg actctctcca tagctctggg 47700

tcactaactc ctagagatgt gcctgcctct gcctcccaaa atgttaggat taaatatctg 47760

tgccaccaca cctggctctt ttgttaattt taaaatttac ttatttactg tgtgaacgag 47820

gggagggggc agcacaagtg tggggtcaag gttcaacttt tagaagtctg ttgttttgcc 47880

aagtaagtcc atggtatcaa actgaagtcc ttagacttgg caacaagcct attggtctgc 47940

tgagccctct tactgcccca ctgtgtccct agaatagacc tcatgggaca tcttgggagc 48000

gtccttgtcc tgaagtcctc caacttcttc accttttcct taccatgacc ctgttccctc 48060

ggaatctttt agaaggacct gggcacacac atcagcctcc cctctcccct actcatcctt 48120

tcatatatat acacacataa ctgagctata agcgctctct tcactgagcc ctcacataaa 48180

tttagatggt gtctatgacc aacggagttt tgtgggtgtt tgagacaggg cctccatgtg 48240

tagctctggc tgtccaggta cttgctgtgt agaccaggtc ttgaactgca ggtgcctaac 48300

aagtacatac cacccaaatt aacatggagc acctccgtac tctctctctc tctctctctc 48360

tctctctctc tctcacacac acacacacac acatacacat actcacacac aaagacaact 48420

cctgcgtccc tagtccccag cacacactgc gttctccagg aaataagtgt tgatgctttt 48480

gtctctgacc taaagctcat ttctccattc attaggagac tcaagtagag aacatttcag 48540

gctggggatg tgattcagtg gatacagtgt ttatagctta gttgagataa tgtttatagc 48600

ttagttggga tggggagact gcttgtgatt acagtacatg tgactcagta gacagagtat 48660

ttatagctca gtgggtagag tgcttgtagc tcagtacaat gcttgcattc agtgggtaga 48720

attaagtggg tagagtgcct gtagctcagt ggacagagtg cttgtaattc agtgaatctc 48780

atatctaaat ttgctgaaca ggccccctct gtccagcagg tctaatgtag tcttgtttcc 48840

ctgtactcag ctgtgatctc ttgagtcctg tgcctcagtt tacttttcag tgcttccatg 48900

gcctgctgcc ttatggaaag ccagtactaa atcttcagtc ttacaagggc agaagatctc 48960

cagtctgtct ggatgggaac atcctcctta gatgaagagt cacatgagca gctgtcagat 49020

gctctgacag atcactacag gctagtgtct tttacactag agaggaatta ctgagggtcc 49080

tgtgggggat gggggagttg gcatctgaga tacattgagg ccatctggta gtccatagtg 49140

acattaatac aaatttagaa ctatctagga gacacttgaa gtccagatca ttgaggaaga 49200

agaatcctgt gcatgggtgg ggacccagag tgcttaaaag ggaaatcaat tacccattaa 49260

tattgccaag tcaccagcgt tcatccctat tgatgtaagg agagcaacta tgtcctgctt 49320

ttgcctccat gaagtcatct cccctggaag gcccactctc accaccatac aaccctagtc 49380

attagtaatg gtgtaggctg tgggagttgc attaacattc atgaatatgc agatatacac 49440

tctgtatata cacacccaca ttgtacaagg ccagcctctg cctctttcta gaccagtccc 49500

attgtgcaga ggagagattg taatcaccca tagtacactt ggctgttctt ttgcaaagtc 49560

cctaaaggtg gaatgctgtg cacaatgcct cccaccatgt catcacttcc ctgagtgcta 49620

ccttctaatt cattgtggtt tatgagatgg ggcttcactg tcattcaaac caggcatcca 49680

ctccaaccga aactaaagga tcatgggttg gagggatatg accacaggat gtctggaaca 49740

cccagaagca ggacatggtt gggagggtct tctttgaggc ctgcaggaga tggggagtag 49800

ggggctgatg gacctgtacc tcatatttcc acccttggac aaaggataac aggtgagcct 49860

acccactttg tgccaccttg gatgtcttct gttctatgtc atcctgactg aacctatctg 49920

ggccatcttg aaccccaccc accctgagcc atcttaaatt ccacctaacc tgtgccattt 49980

tgccttgaag ctatgtatgc tatcttgaat agcacgtaac ctttgccatt tgaatgccac 50040

ccaccctgga ccttcttaac taaaccatct agaaacccat ccaaggcagc catcttgaat 50100

tgctcactgt cttgatatat tctttcaggt ttcttttctt gactgttttc tcctgatagt 50160

ataaagaacc tgtcctgtcc tccttctcaa cccctaaacc ttgtctgtgt atctgtccat 50220

ttcctgctca gcccttagca tcctcatcct gaatcaccaa gggtgataaa tcacactctc 50280

tctctctctc tctctctctc tctctctctc tctctctccc tccctccctc cctccctccc 50340

tccctccccc atgccccctg cccctgcccc ctctcccctc tcccctctcc ctctccctct 50400

ccctctccct ctccctctct ctctccctct gaaaggcact tgtcctgagc cactggtggt 50460

cctagagtga gtttcaggat gattttccta caaggacatc acccaaaagg agagcaggaa 50520

gtcacagctt cagtcacgca ggccaaagct tcttgcttca atctcgttta gagcctggat 50580

gctctagtct tagtctaacc acacactaag gacagcacct tcattctctt gaggacttat 50640

gcatccttag gcgttctctg tattgacatt ttcatttaat tttatttttg aagtgctggg 50700

tgttgaatat agagcctcac tcacattaag aaaatctcct agtctctctt aagtctcctc 50760

tgtcctccct ttttctttcc agagtctccc agagtagctc aagctttcct ggaactcact 50820

gtgtattcca ggctgccctc aaaccgctgt taatccttct gccttacttt agaagtgcta 50880

ggattaaagc ctaccctact aggctgaatt tatgcaaagc ttgggattgt gtcctgggct 50940

tcatgcatac tacacttaaa tatcctactt ttagttttat ttcctatctg aaataaccac 51000

catgccatca cacttccttt attttaaaaa gatttctccc tgaggctgag ggtggaactc 51060

agtgatacag agcttgtaat tctgttgata gggtgcttat ggcttagtag attggctctt 51120

cctgtgggag gccatccaag ctaatgacac actgctgtac ctgatacttg gctccttcag 51180

gaattatctg ggttgtgttt ccagtccact cttctgttta tattttcctt tccaaggcta 51240

gggttagaat gtgaggggaa tagtaataat aatagccaca gtaataaccc acttattatt 51300

attatatcta ttatttgggg ggttggactg gaacccagtg cctcatgcat gctaggtaac 51360

cagccactga gctgctacac acagagccca agagcaaact tgttagtagt agtatcatca 51420

cttttttttt gtttcttaca tttattttat tgcatattgt tagtaaatat tccatttaat 51480

acaattatgt tgtcaaaata aagcaagaaa tagtgctatg actcattgtt gacatatacc 51540

acaaatgata acataaaact ccagtataag agaaacacac acacaatata tatatatata 51600

tatatatata tgtatatcca gtgttctaat tttatgtaca gttttaagtg ggggtaaatt 51660

ttaaacattt ctattttttc caattttttt attggattgt tattgctctt attgttgctg 51720

tgtgaggtgc tgggaatgca accaaggaac tcatttatgc cagtcctgag ttccagcgct 51780

gagttgcatc cctagcccat ccttcctgcc tctatatcaa atgctgtatt gaccttggac 51840

aaaaatcaca atttcccaat atgatgggga aaaggaaagg acctgcatct atcttcacag 51900

cctgctgcaa ttgttcctgc ttgtgcatgt tggattttga aacccagttc tgggtatctg 51960

ggcgacttcc atgtaacatc ttcctcagct accccaggag ccttgttacc cacataaaag 52020

tttacatttc ctcctcacca tgtcagacac agaaaattat gtctgaaagg ttacaggtgt 52080

tcatgtatgg aacacttgac taccatttgt agagcatgtg tgtagattag atcttcctct 52140

gaggtagtca tttggggttt ttgttgttgt tgtttgtttg tcttattggc aaaggcattc 52200

atccttgtgg aaggcaacct tggaatctat aagggctgta aagtaatttg caatgaattt 52260

aggtggtgtt gtttgttacc ttgatgacct gtgacctctg agtcacctta taggtcaagg 52320

gactctgctg tagtgactgt tgtaaatggc tggggtatga gcatcaaaga tggagtgatt 52380

ttgtatcaca tagggatgct gggacattga ctgggatagg catatacaac atacatttga 52440

gtgaatgtag gttgtgttga tggcttacaa ccaagggatt gggggtggag gaggaggaga 52500

gacaagcaac ttaggtttgg gtccaatgac aacacaattc tttcttacag actttgaata 52560

ttggtgtgga atgtgtatta gctagcttcc cattgcagtg acaagatctc tgacattata 52620

aaattataaa gaagaatgat ttgtggtggc ttgtgctgtc aggcatccat ccatggctct 52680

gttggtttgg acctgtggag atttagagca tcatgggagc ttgtagtaga acagagctgc 52740

ttaccacgta gtggccagta cacatagaaa agagaagatg agtcccagtg tctccttcaa 52800

tgtcatgccc ccaatgagct aagtttctcc cactaggcag taaatagcac cttaccctga 52860

gactttctgg tccttttgct tgactttgtt ctgacagctt ctggcagttg gcactctgct 52920

gtactgttct tttccacagt gttaggtttc tctctcagcc tgtgctctgc tctgtgtaat 52980

caacaccacc agctgtttct gcacccacaa gtctcaggca caagtgtgaa ggaaacaagt 53040

cggtagccat ctgatacaga agtcatcctg tggactgcgc atcgcagtac agctgtcaca 53100

ggctctcttc acctactgta ctttgaacac aaaggtgaca tgtgatccac caatcagaag 53160

cacaggcaag ggttccagtg tcaagaccct tgcttttctc attttgctgt gacaaaatgc 53220

ctgataatag gaatttaagg ggagagggga ttattctgac tcagactgct gctggtccat 53280

catggaggca ggagcaaaga gaaggaatgc tggggctcag cttactttct ggatccagga 53340

ccccagcaaa gggatggtga tgcccatatt cagggtagga tttcctacat cagtgaacta 53400

gatgttctgg ggtagcttgg agcaaactga ggttatttta agcattttca gcttgattat 53460

cccgttcctc attgaaatgt ctataaattc tcacccacac tttctatcca tctgatccac 53520

tgtaggccag tcttggcttc cactcaggct atgactctgt gtccctcctc cattcctatg 53580

tattctgtgg caggtgtctc ctgactgata gacatcacct tttctttaaa gaacaaaaca 53640

aaacaaaaaa ccaacaaacc ccaaaaatcc ctaagcaccc aagaccaatt ttatatccca 53700

attaattcat tgtaagctta gatagcagaa gtaaaagaat gttttttgag gctgggcatg 53760

acagaggatg cctgttgtcc cttttaaata actttagtac taaacatggt ttttttgtgg 53820

ttattgggct gttcggcctg ctgtctagct gtgggtgtgt ccttcttgat cctgcatctg 53880

gatctagctt gctgtgggga gcattctgta ttttttcccc tttttattgg atattttctt 53940

tatgtatgtt tcaaacgtta tcccctttcc tggtcccccc tcctgcaaaa cccctgtccc 54000

atttccccct tcctctgatt ctgtgagggt gttcctccac ccaaacaccc accttaccgc 54060

cttcacactc cctatactgg ggcacctagc cttcacagga ccaaggacct ctcctcccat 54120

tgatatctga caaggccatc ctctgctaca tatgcagcta gagccatgag tccctccatg 54180

catactcttt ggttggtagt ttagtccctg ggagctcagg cagtggaggc ttctggttgg 54240

ttgatattgt tgttcttcct gtgaggttgc aaaccccttt agctccttca gtcctttctc 54300

taactcctcc attggagacc ctttgctcag tctaatggtt ggttttgagc atccgcctct 54360

gtatttgtca ggttctggca gggcctctca ggagacagct atatcaagct cctttcagca 54420

agcacttctt gtcatcctca atagtatctg ggtttggtga ctgtatatgg gatggatccc 54480

caggtggggc agtctgctcc acactttgtc tccatatttg ttctgtgagt attttgtttc 54540

cccttctaag aaggaccgaa gcatccacac tttggtcttc cttcttcttg agcttcatgt 54600

gctctgtgaa ctataacttg ggtattccga gcttttgggc taatattcac ttatcagtga 54660

gtgcatattt tttaatggtg agaaaagaat gaaattgtat gaggtttgca ttttttttgg 54720

agtacatcat aagatgtcct tttctacatc ataagacaga aagcaactgt gtttaaaggc 54780

tgggatgggg agagaggtgg gggatggatg aaggaatggg ggaatggatg ttggtgcgtg 54840

agggtggatg agttagtata tagattgaaa tggaagagaa agagtaagag gaaaagagga 54900

caagatggat atggagctag aagagaaaag gaacacaggg ggcataggga gagatacaga 54960

tggaggaaga tgaagaataa ttaggaggaa aatagggaag agatgatgaa agggcagatg 55020

aggcagaaag ttcagtggag gaaaaaaagg aggaggagca gagagattca gaaagagaag 55080

aagcaggaag tcttggaaga agaggagggg agggggtagg agacaataga ggcagataga 55140

ggtggaagag gaaggcagac agagagagca aggattcaaa gttccccacc aggagtcacc 55200

aagtccagca tttcagctct tcccatggct gtgtttcaat ctccaatgca catagcaggc 55260

aattatttgt tttaggtttt agtcattatt attactgtgc atatttgtgg ttgtaggcaa 55320

tagcatgctt gtggacagac atcacaggaa actttgttga gtgactgtcc attcattccc 55380

caaagcaagc tctttaccct cagagccatc tccctggccc cttgattgac agttgtgtgt 55440

gaaaaaatat ctatacagag ctcaagtgct catctaagtt tcttttcttg tatttatctt 55500

taaggcccca gattggcatg atgtccattc ctcaggtatg tttccttttc ctgatccttg 55560

actgaatgca ttgtcttcct caggcactgg gacctttggc cgtgtaaacc tggtgaagga 55620

gaagacaggc aggcaatact gtgccttgaa gattatgagt atcccagatg tcatccgcct 55680

gaaacaggaa cagcatgtgc agaatgagaa agcagtcctg aaggaaataa accatccctt 55740

cctcattaaa ctgtgagttc ctggctcctt cctttccacc tcctcacctc cctaacgtta 55800

ttctcccaag agtgcgatgt aggggtgctg ccagggctgt agctcagtgg atagagtgct 55860

tttagctcag tggatagagt gtttgcagct caattggtag agtgcttgca actcagctaa 55920

tacagtgctt gtagcttaga gggaagagta cttatatata gctcacctta tggaacgctt 55980

gcagctcaat tgttagagtg cttatagctc agtgggtaaa gtgcttgcag ctcagctaat 56040

acagtgtgtg agtagcttag tgggaagagt gcttgcagag cagtgataag agagtatgta 56100

gctcagtgga tagagtgctt gtagctcagt ggtgtgaggt gggagatact atccagattt 56160

tgtcttgatt tattattgtg tgtgaccatg cacatgggca cagtaccaca caaaggccac 56220

aggagagcac tatatttcct tggaacttta gttacaggtg gttgtgcact gctcaattgg 56280

gtgcttggaa tccaatttac atctttaaga gcagcaagtg ttcttaaatt ctggtccata 56340

cctcaaccct taacttagga gtttttataa caactacttt ttgtgtgacc tgaccaggag 56400

ccatgattct aacagtctct tcaatgttta tgcccaaaca ttgcttatgt tatgtaaaag 56460

tccaagacct gggtctttta ttacggcttc tagtcaaggt gacagagtaa gctaattatt 56520

catttgatat tcatataaag caactggtga tttttttaac aatattaaat ccctctttga 56580

atttgagaaa tatagatgta tataaaaata cttatataca tatatagtat gtgaaggtcc 56640

atatgggcgt atgcatgtgg agatctgaga acatctgctg tcattcctta atttaaagtg 56700

tttgagacaa ggcttcctga tagcccagga cacagaaagt ccagggagct tcagggaggg 56760

taaattaccc agcatgtcgt tattgaaaca ccactgcaca attgtcatgc tattctagag 56820

tattctatgt tgtcagaaca ttacataagt gcactatagt caaaattcat tagatagtgt 56880

agaaactaga gcatcgggct gaaggagaag gatcaggttg agtacttgtt ccttttgcag 56940

agcacctggg tttggttccc agcactcaca gcgcacagtc atctgtaatt ctaatttggg 57000

gacacataca cacaaataaa tatgtaaata agatacaaat aaatatgtat ttttaatatt 57060

tgaaacacag ggcatttaaa ttctacacag acttcaatat tagccaaaat atgttcctgt 57120

tagccacagc accaactgag gctcatcgct ctgtgagtgt ttgtgtccca gtctcctctc 57180

cttatgagga cccagtcctg ttaggtcatg tctaccccaa agacctcatt ctaccccagt 57240

ttccccattt aaagatccat ctccacacag ctctgtccca aggtcctagg tatgcagaca 57300

tttaatacag gaattctggc agaaagaatc ctgagtgctt agctaagtca gactggacaa 57360

ttctacccac cactgtgtaa ttacacatgc cttaaaggaa tcttttcttt tttgctttct 57420

ttatcttgca tttacaggat tcagcaggtg ggttaaaaac tatgtcaaag tgacttagtg 57480

ctatagagat ttgcacttgg cctgcatgct gtattcacag catggcagag cacactgtat 57540

atctgtccag ctgtaggaac acaacttagc aggtctttga acttcaaagg atgatatgca 57600

tgctacttaa ggcctttaaa gtcttatact ctgtccttta actgtgaaca cttgtgaggt 57660

catccatcca acttgtgcat gttgcctatg aacatggagt agtctgtctt gaggaaacat 57720

gggatgccca gcatagtggg aaaggcttca aacggctgat gaaaatcaca gcttacattg 57780

ctgcagaaat ctggacttat ttacaaatgg ttttaacaag agtcagtatt aggctcagcc 57840

tactgtacat ggcactattc ccaggacagg gaaaaatgtg tgataagctt caactatcaa 57900

ttggcacaac ccaaaatccc ctgggaatgg tttcactgag ggatttccca catcagtcca 57960

gcttgtgaat atgtctgtga gagtgttcta attgatgatt gacataggac tccacccacc 58020

atggacaaga tgagggtgta gtgtcaattt gacacagaaa gtttgtgctc tacatgcata 58080

ccatgaccct tcatctgtgc tttcattcct ttatgtcaga ggtatttgca catagaggta 58140

taacaagaaa tgaagtcttg actgggctgc actgtgcact cttgaaaggt ccagtgcctt 58200

tgggtgccct actgtgggtg ctgagagaag aaacctctca tcctaggggc ttataatcag 58260

agtgctcttt agacattgct ttgtacccct ggagagcaat gatgtttctg gatgaaaacc 58320

ttgtggtagt tgggtgggaa ttacttgcat gatatatgat agatagatag atagatagat 58380

tagatagata gatagataga tagatagata gatagatgga tggatggatg gatggatgga 58440

tggatggata gatagtatat gtagatgata gcagatagat gtacgtagat aacatagatg 58500

atagatcatg aatggaagga caatagatgg tagaaaggtg atagatggtt ggatagatag 58560

gttaaatagc tagataatag atgactgact gatagataat gataacatac atacatacat 58620

acatagtatt gacggtaata ttgaaggtct cacctagggc accatctctt agcatatact 58680

ctccttgtga attccaccct caggttgtca ccacagtttt agcatcctct gatattctaa 58740

tatcaacctg catctacagt ccagctaagc acaaccttat gatctgggtt gactgacatc 58800

agatatctta tcaaacatct tgattacttg ctggtgagct ttgattctgt tgtgattaaa 58860

caatgactaa gagggactga gggtaggaaa ggcttaactt ggctacttgg ctttcacttt 58920

gctgtcacag gccatctgag aggaaagtca gagcaggaac cagaagcata aagctttcat 58980

ccagcccaag aacccagtcc atgatgggtg gggcttccta tgtcaattat caaacaggac 59040

actccccaca gacacccaca ggccaatcta atgtgagaaa tgactcactg agaccctacc 59100

taggtgactt caagctgtgt tagagctgac agcacatctt ccccctgcta gggactggcg 59160

ccaccctcca tggagatgat cgtcatactt caatcaacta atcagctgaa taaagacatc 59220

cccccataga catgcccaca ggctaggatg atatgggaaa ttcttcactg agtaccttcc 59280

caagtgactc tgggtcataa aggtgatggt taaagctaac caggacacat tcacatgttt 59340

gcatctgttt atgtgtttat cttgatatct gtatttatat tttgatattt gcatatatgc 59400

acctgttagt gtctgtgtat accagtatat taatgggaac atctacctct gtatatctgg 59460

agtctgtaca catatcttgt catcagtgtc tgtcaatcac caacatacat ccatccatga 59520

gtatccactt ctgagcaccc aacttattac ccatcgtgca ctctgttgtg tctcgcaggc 59580

tttggacagg ccatgacaac cgcttcctat acatgttgat ggagttcgtg cctggtggtg 59640

agctcttcac ctacctgcgt aatcgtggcc gattctcctc agttgcttca gtcttctacg 59700

ccacagagat tgtgtgtgcc atagaatatc tacactcaaa ggaaatcgta tacagggacc 59760

tgaagcctga aaacatcctt ctagacaggg aaggacatat taaactgaca gacttcggct 59820

tcgccaagaa actggtggat aggtgagtgg gaacagccat tggctcatca gaggttaatt 59880

aaaaaataaa ggtttgattt aaatgggtgg acagaaaggg gcagaagatg tatggtgggc 59940

tctggtgtga tgcacttctc cctccatcta tttagatggg tctcccattt ttcccccatt 60000

ggtatagtaa taaaaccatc tttaaaaagc agattaagga agaacaggga taaaggtgcc 60060

aacaggagca tgtgtagagg acagctgttt acattgtagc cacatatagg aagagcaagc 60120

aggaagtaga gcagggttat tgtcttagtt agggttttac tgatatgaac agataccatg 60180

aacaaggcaa gtcttataag gacaacattt aattggggct ggcttactgg ttcagaggtt 60240

cagtccatta tcatcagggc aggagcatgg cagcatacat gcaggcatgg tgcaggagga 60300

actgaaaagt tctacatgtt tggctgaagg cttctggaag actggcttta ggacatctag 60360

gatgagagtc tcaaagccca ataccagagt ggcacaccta ctccagtagt gcccctccct 60420

gggccaagca tatacaaacc atcacattct actccctggc ccccataggc ttgttcaaac 60480

atgagtcatc cacgggggcc atgcctaaac atagcatatt aaaaaaatac atttagtcca 60540

acttccaagt ccccacagtc tatagcagtc tcaataatgc taaaagtcca aagttcaaag 60600

tctcatctga gattcaccca atcaattaac tgtaatcccc aaatcaaggc aggaaaccag 60660

ctgggcaaac tcaaactctg aattcccatg tctgatgtca aaggagtctt cagatctcca 60720

gctccttttt catcattgtt gactgtaaca aatttctttg cctgggctgg ttccactccc 60780

ttttagcaac tttcctcaac atgtatccca tgaccctggc atctttaaca tcttggggtc 60840

tccaagtcaa cttcagcttc acagcttctt gttccagtgt ctgggatcta cacatgatct 60900

tctgggctcc tccaaaggac ttgcattgcc acaggtcctt cattcccgct gcaacaggaa 60960

cttcatggac accaagtcgg gttcacacaa tgacttcttt acttgtggct ttttccttta 61020

cagctctctt ccccagcagc ttcttcttag ggcaagggct aaactacaac tcctattaca 61080

atagcttctc ttactcctac ttctactcac agcaagggct aaactatatt caaaccgact 61140

cacctccttc tagctccacc ccacctcatc caatcagaat tcacacacgc tctaggcatg 61200

agctcagatc gttcacagat aggctgacag gtcctgatca caagggatag tctagcctgg 61260

caggcagccc acgcatgcag cctcactgca catgctcggg caaggcagta aacaacttgg 61320

cccatgcagc cacatctgct tcccgcgtcg catcacttct tcaactctgc cctctatagc 61380

actatagtct ctggttgact ccactccact gctgctgcca ttcttggtac tgacatctta 61440

aatatgctgg catcttccac agcaactagg cttcaccaat agcctctcat aggctctctt 61500

catggtgcca ggcctcaact ttgcatggcc ccctcagtcc caggccatca actataactg 61560

agactgcacc ttcaccaatg gctccccatg gcctctcaca gtgctaagcc tcagctgctc 61620

tccatggccc cttcatacct tcaaaaccag taccacttgg gtgattctta tgcattatca 61680

agtccagctg caacatgaca tacaacctcg gctatctctg gaacacagct tctttgtgct 61740

ttcagaaaat acttctcaga agatttcact tcaatgatgc tggtcttaat cactgctaat 61800

atcttagctc cagctaacca gcaacaattg ttcctgtagt cccttttatt cttgactctg 61860

aagctagagc cacatggttg aaactgccaa attctgcagc ttgctagtgc cggaacattc 61920

tgcccactta ttctattagc agctttctat tttccaactc cctcaaggct tggctgtcct 61980

tgaacttgca ctgtagattg accttgaact cagagatctg catggctctg tctcctgaat 62040

gcccctccag attgtgagca gaagagaaaa ttgttctgcc atcaagatgg ttgaatatgt 62100

tccagaaaat tccaatattg tatgtgtgaa tgttttcata attgcatata gatagatata 62160

tagattactt atatcatcat ataatttata tatctatata atcctaccat tcctgtactt 62220

aagcttttct tcacctagaa cttgctctgt accaggctgg ccttgaactt agaactgctt 62280

gactttttct cctgggatta aaagtatgta ccagcatgcc tgggcctaag cttttcatag 62340

ccactgtttc tcaagatcca gatcaaaagc ctgtgtcttc tagcctcaag atctggatca 62400

caagtgtacc cttcatttct agattgtagt ttattccaga ttaaaagtcc acactattcc 62460

ttgtttaact gcaaacacaa gcagtaggtt tagctaggtg ggttcttgca gtgagattac 62520

cactccctga atgtctttat ctccttgaac accggattca gctccatttc acttcctgga 62580

gtccctttat aacttggacc atacatttta tatttttcct ttctcagctt gtttctcttg 62640

ttcaaaacac ccttcctgag acttaatcag agaacaaagt ttctgttggg ctttttgaga 62700

cttcctttgt caatgcaatt aatataaatc tctttacgtt aacctcaggt agacgcttca 62760

ggcaagggca aaaagcagcc ccattcttca ccaaaatatc acaagtctct cagccacata 62820

ttaaaattgt tctcctctga aatctctata accaggcttc cacagttcaa atcactcaca 62880

gcaataacat cttccatatt cctaccagga tggcccattg agccccacat aaagcattcc 62940

agtgctttcc aaatacaaag tccccaaatc cacattcttc caaacgaagg catggtcaga 63000

cctatcacag taatatgcca gtccctgata ccaacttctg tcttattact gctataaaca 63060

gaccaaggca actcttttaa aaacatttat tggggctggc ttacacgatc agaggttcag 63120

tacattatca aggtggaagc atgacagcat ctaggcaggc atggtgcagg cagagctgaa 63180

agttctacct cttcatctga aggctgctag aagactggct ttcggacatc caggatgagg 63240

gtctcaaagc ctatgtccac agtgacacac ctactcaaac aagggcacaa atactccagc 63300

atttccactc cctgggccaa gcacatatag accatcacat ttaaaaaaaa aaaccttgag 63360

ccccactgct actgacatac tttctcctgt gaggctccac tttacctaaa gcttatccag 63420

aactttccca aacagagctg cctgctggac caagtgttaa aatacctgag cctgtggggg 63480

acagcccaca cctagtgtac agctatggga gtggagaggc ccctccagat tgtgagcaga 63540

agagaaaatt gttctgccat caagatggtt gaatatgttc cagaaaattc caatattgtg 63600

tgtgtgaatg ttttcataat tgcatataga tagatatata gattacttat atcatcatat 63660

aatttatata tctatataca tttatatata actatattat atatatttgt atattttaca 63720

cacagtaata tgctcaggga tactatagct ggatcacatg gcagttcaat ttttttagtg 63780

ttgtattttt ccccataaga tacatttatt ttatgtctct atggtgtgcc tatatgcatg 63840

tcatacccac agaggccata agagggcatc agatacccta gacctggagt tacaggtgaa 63900

tgtgtgcagt cttatgggta ctaggtgttg aacccaggtt ctctgcaagg gcagccagca 63960

atcttaaagc taacatgcct ctccagcctc tgtcttagag ttttctattt atagaactca 64020

gtccttaggg tcctttgccc agggctcctt cccctattca tagctatgga agttctttac 64080

tgataatgaa gaagatggtg tcatgttcct gttaacccat agccggggta gggggggaaa 64140

ggctcaatat tgagggaatc agatactttc cagcctcaaa gggtgtccat gctgtgtaca 64200

gattctctat gatcccagta ttgctgtggt gtgctaagta cccttaacca gccagccagc 64260

cattggtgca ttttgtaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaagaa tgtgtgcaga 64320

aaggttcaaa gctataggaa caagccagaa ctagaaaatt ccacagcctg aggcatgcag 64380

gcctccagcc tggggcagac acaaaaagac tcagctttca gtggggtaag cagagctgcc 64440

tccggtagag ttacctgtga cctcatcagc tcattagctc tatctgccct gatcttgttc 64500

tgagacaagg ctacaaggat caaaatctga gttattgggc ccaggggcaa atggaatgtt 64560

gggagcctgt gatggactga cttctagttg atttccatta cggagagaag agaggaggca 64620

gagggtgtat gtgcagccca ggctgtcata gcactcacta gggagccaag gatgaccttg 64680

aactgatccc tcctatctgg acctctggcg tgctagtatg acaagtaagc atctccacat 64740

cttgtttatg ctggggttgg gatctgggct cagtgcctac aaggcaagca ctctgcccat 64800

tgagctacaa gcattctgtt cctggtccta ccctatagtt ctatcccttc tgagttggat 64860

cagttcttta caggttcttg actcgaatcc ccttctatct gttccctgtg ctgtactgct 64920

cagaagctct tgagttttgg gccctcatct ctgtcagttc cttcctgagc cctagaatcc 64980

ttattaggaa gtcttcctga tatgtccgtc tgtgggtatc agggttggag caaaatggat 65040

ggaactgagc aatggataaa ttcaaggaaa catgtaggct tgaaattgtc ttaatagaat 65100

cagttatttc ttctttctct tctaattcat atctttgccc cttttctttt taattgcaca 65160

gtcttgccat acagcccagg cacccccaaa tgtcattatc cctttgcctg agtcttctgc 65220

atagttagat tgccagtggg agccccagac tgagcataga attttccttt taaaaacatt 65280

actttattat tttatgtgtg tgactcttgt ctgcatgtct attatgtctg taagtctatg 65340

taacacatgc attcctggtg cccccagagg tcacaagagg ccatcaggtc ctcctgaaac 65400

tggagttaga ggtgatttta tcaccactat gtggatgctt agaatcaaac tcaggttccc 65460

acaagaacaa gtgctcttat tcactgagcc atctcttgat cccactttaa aaaataatta 65520

catttattta tcttggatgg gggagagtac agttcagagg tcaactttca gaagtcagtg 65580

ttctgttacc atgagggtcc caggaattga actcgggttg tcaagcttga cacaattgtt 65640

tgacctgctg agaatctctg cttcaagcat gcttaggcct ctctcaactt taccatggtc 65700

ctagcttcag gacattttga tcatatgtaa acatctctcc tcatttgtgc ctcatgaccc 65760

tgtggtatgc ctctctggat cttcctagcc tacatacttt acacacacag catcattaca 65820

atattttttt tttatttttt gttccagctt atgtaatggc attgtctatc tatgaggtac 65880

cactgtcaaa cttactgtcc ttttcatggc tgaataatat tcctttttat agttggacca 65940

catggtgttt attaaccttg tataacttaa tttacttttt atttgaatct ttcttttgaa 66000

gaaagaaaca atcatttttt cctattttat ctttctttaa aagaaacaaa tcaacttttc 66060

attttgtata ctctgcagct tgcagctgct tgccacacca attggctctt ttaaatataa 66120

attaaagcag gacaaggtag cacttgcctt tgataccaga tagcattcaa tgggcagaag 66180

aaggtagatc tctgtacgtt tgaggctagc ctggtctata agacagccaa ggctacacag 66240

agaaaccctg tctcaaaaaa aaaaaaaaaa atagagcttt ttgttctttc aaatgggttc 66300

tttctttaaa attattcttt tctcctgtga ggacacagta gaaagcctga agctatagtt 66360

ttgtggtaga gcagtttacc aaggatagag cttcatggta aaccagttag gtaatgtata 66420

aggccctggg ttccatcccc aggactgtag gatctgctgg tggaagagta ggatgtagtc 66480

tccatcccag cagggagaga tggggagaat tttttttaaa aagaaacaaa caaaaatcct 66540

agatttgtcc aaacatccta ctgtccttca tctttcttgt ctgtgggtgg caccaaaagc 66600

taaactcaac ctccaatcct gccaactgtc ctaatttctt ttgacaaaaa tgtttcttga 66660

tgagggattg gagagagaaa ttatcaacat tctggaaatt tttctcttca gaaaggagct 66720

tgttgccaca caagcaggaa gtgctggcac agcagagttg atgaggagag gagaggggtc 66780

atattatttt ttatttcttt gatttttgac acaagcccct gatcccacca cttgggaggc 66840

agaggcaggt ggatctctgt gagtttgagg ccagtttgag atctatagag caagttgcag 66900

gacagcataa gtacatagag agaccttgtc tcaaaataca caaaaactct gaagtcctga 66960

tcctcgtgcc tctacctcca tgctatgctg gaaattgaac ccagagtcta aacaccagcc 67020

atgctggtac caacgatgct gtaccaactg agttatatcc ctagccccta tcactaatgt 67080

taaaaattat taatactgca tattgattta cccacccatg atggtttgta tattcttgga 67140

ccagggagtg gcaccttttg aaggtgtgac cttgttggaa ttggtgtgac ctggttggag 67200

taggtttgtc actgtgggtg tgggcataag atcctcaccc taggaaagag aggcccatta 67260

gtcttgcaaa ctttatatgc ctcagtacag gggaacgaca gggccaagaa gtgcgagtgg 67320

gtgggtagag gagtgggggg gggtatggag gacttttggg atagcattgg aaatgtaaat 67380

gaagaaaata cctaataaaa gtaaataaat aaataaaata aaagcaaaaa aaaaaaagcc 67440

tcaccctagt tgcctggaag tcagtcttcc actagcagcc tttgaatgaa gacatagaac 67500

tctcagctcc tcctgcacca tgcctgccta gatgctgcca tgttcccacc ttgatggtaa 67560

tgaactgaac ctctgaatct gtaagccaga cccaattaag tgttgttttt tataagactt 67620

gccttggtca tggtgtctgt tgagttttgt ttacttttta agtgttttta ttttaagttg 67680

tgtatctctg tgtgtatgtg tatgccagtg cagtactagc tgaggacaag aaatgatcat 67740

gggatcatct attaactaaa ttaaattgaa gttaatgctt gtaagtaaag aacattcagc 67800

aaggaacttg ccattacagg gtcagtttat gtgataaata tagatggagc aactagaggt 67860

gatggtctat gcatataatc caaggagtgg gcaagtttga ggccagccag gcctaaaaac 67920

aaggaaaaga gtatagaatc aggagtgttg ttgtatatat gctgagtgtt tggacacatg 67980

gtacaagtgt aggagtcaca gcatgaacaa aagcattttg cactctgttc tttcctacct 68040

ctcacccgcc ccagacagga tttttctgtg ttcccctggc tgtcctggaa ctcactctgt 68100

agaccaggct gacctcaaac tcagagatcc acctgtctct gcctcctgag tgctgggatt 68160

gaaggcgtgt atcaccacca ctcagcttct tctacctctt ctgtagatct atcttatact 68220

tgtacaataa tctaccagct aagccatgtt catgtaccta ggcacatgta acaggttcat 68280

gtacctaggc ccataggcca atctgatgtg ggaagtcctc cactgagacc cttcccagga 68340

aattctggat tgtgtccgct gacagttaaa gctcacagca cagcttcgtg tgcctgggga 68400

atgggtctac ccatggtgac tatgacttgt gcctctttca aatcatggaa tcttatactt 68460

gtcacatcat tgatgcttag aaagttttag atttaggagc attttgtttt agttagaagt 68520

gttcaaccta taaggccata tgttaatttt ttgcacagtg gccacacttg tagtgtgatc 68580

tttatcgctg tatcttttag caccttccaa gtttcatgga ttcatgcttt tgttaccccc 68640

acaggacatg gactctctgt gggacaccag aatatctcgc cccagaagtc attcagagca 68700

aaggtcatgg aagggctgtg gactggtggg cactgggcat tcttatattc gagatgctgt 68760

ctgggtgagt gaccctcctg acagacatgg ctgcatacac ggcctatgaa gaaccttagc 68820

atcccctttt tcctaagtct gcagatacat ggcatatgga tgcactcaca taatgtactg 68880

tcaagattga agggtgattg ggtgtttagt ttacttaaac aagactttaa cgtttcatag 68940

acatccatag ttacttatgt ataacatcca tcttctttat gtgatggaca cccaaggcta 69000

atcagtaccc aaggtgaaca aatgacacta atcagaaaca gctttgtaag tagtgatgga 69060

agagcagatg aggaaggcaa gctcagttgt tttattcacc ctaatttccc tctcttggca 69120

atgcacaaga tacaggagtg tgggctctgt ctctgtctcc cagttgatgg gaaggttggt 69180

tgttcctgat ggtcactggt agctgtggag gcaagtatac acctgataaa aattgtgtaa 69240

acattgaaag caagattccc aagatctagg tgtagccgag ggaattgtag gccaatacca 69300

tgggagagtt attcctctgg ggaggtgaca gttttcccag tcccaggggc ttttctctgg 69360

tactgagata aaggaaaatt catcctttgg tagatcaacc caggtaggaa aaaagcttga 69420

aggaggattt tactaaaata gtgtgagatc tgtcaagaga aagaaagcat ctccttaccc 69480

acccaccagt catctatcta cccactcatc tatccacatg tctattcacc tacctaaggc 69540

attaatccac ccacccatcc atccatctat ccactctttc agctcctgga ggtgccaggt 69600

gtgcttggct tttgtagccc catcaccccc atctctgcag ggcttctgtg agtctgcatc 69660

tctttttttg tctgtcatga ggtcactgtc attgcattta aggtcatctg cagccagggt 69720

gtgctcatgt caagatctgt cactcattct ctaggcagag accctatatg caaatgatgt 69780

cacagtcatg tgttctgaaa aatgtacaca tattgtatgt gtttgtaatc catgaagctt 69840

attttcttaa aaatttacaa atataaaacc acatttattt atatacacat aatttataat 69900

atagaacata atttattata tatatatata aaatctatgg agtctaccac atttatttat 69960

atacacataa tttataatat agaacataat ttattatata tatatataaa atctatggag 70020

tctagtatat acctgataaa attgtataat catacacaca cacacacaca cacatatata 70080

tatatatatg tgcatacata tacacacaag agaatgattt agaatcaaca aaaaatgatt 70140

ttttcacatt gaagtgattg tgaagagcct ggggtcccag tgtctttgaa gagggcatct 70200

ccagcaatct aacttcttcc cactaaacct ggcttcttga aggtttataa tgatcacttc 70260

caccccctgc tgggaaggaa gctatcaact gaagctcttt gggagccctc aggaccctcc 70320

atgctgtctc tctcctcctg tggctatacc atctcctaag atcatctgtt tcccatctgt 70380

cttcagatgg tcatgttaac agttatcaag cagtggatcc atttgacaaa aaaaaaaaaa 70440

tgtttgcatc cattaagaaa aaataatagt taacacaaaa tagatataat tctgtattta 70500

actctctact aaatatccat gcttctctct gtgacaggtt tcccccattt ttcgatgaca 70560

acccgtttgg gatttaccag aaaatccttg catgcaaaat agatttcccc agacaattgg 70620

atttcacctc taagtaagtg cactcccggc ccggtttcct gccctgcccc catgtctact 70680

ttcaaagttg tgtgaaatca cactgcaagc atacactcct ggcaaactgg atcagtacaa 70740

ttctgtcagt catttgtttc caccaggaaa gaaaaacgtt tcagttattc tcattttact 70800

gaaatttaat attcaaaaga cctgctacat atctcatttc ttttgagatg gacagtgttg 70860

aaattaacgc agatttggga caagttgtgt aagcgatcag tttgtccatc catccatcct 70920

tccctctatc caactatctg gttttttttt catttattag ttattaacta acttattgaa 70980

acagggtctc aatttatagc cctagctagc ctggctagtc ttgaactcat agatatctga 71040

cccctgagtg ctgagataaa aggtatgcac caccatacac agcttcttta ttaacttttt 71100

aacttgtcta aatttttaac ttttctttga actgttaaga agggcttaga ggaaaagtta 71160

gtttatggga agtatgacct tgaaggagac aatggaccct aggctcttct tcatgatcat 71220

ttccatgtgt aaatatagta ttttttatta attttttgag atacttccac acatatggtg 71280

tgttttaatg gcattggttt atttactgag ctaggagaat ctttgtgaat gaatctctgt 71340

gccaccacaa aagttaactt taattcattt ttttcttttt actgaaattg tacatatcat 71400

aaagaattcc tttttattaa tcattttgtt tacatttcaa atgttatccc ccttcctggt 71460

ctcccctcca cgaatctctc accccctccc cctcctcttt gcctctaata aggtgctccc 71520

cctacccact cctgcctcaa ccctctagca tcccccttct ctgggtcatt gagcctccac 71580

agaaccaagg gctgcccctc ccactgctgc cagatgaggc aatcctctgc tacatatgta 71640

gtgggagcca tggaccaacc catgtatact ctttggttgg tagtttagtc cctgggagct 71700

ctgtgtggtc cagttagttg atgttgatct tcctgtaggg ttgcaatccc cttcaccttt 71760

tcagcctttc ccctaactct tccattgggg accccgggct caatccaatg gttggctatg 71820

agtatctcca tctcttgtag tcaggctctg gcagaacctc tcagaggatg gccataccag 71880

gctcctgtct gcaagcacat cttggcatca gcaatagtgt cagggtttgg tgtctgcaga 71940

tgaaatggat cacatggtgg gacagtctcc agatggcctt tccttcagcc tctgctccat 72000

tttttgttgc tgtatttcct ttagacaggg agaattctgg gtaaaaattt ttagataggt 72060

ggatagcccc atccctccaa aggaggccat gcctatctac tggaggtagt ctcttcaggt 72120

tctgtttccc tgctgttgtg tatttcagct aatgccatcc ctattgggtc ctgagagcct 72180

gtttcatccc tggtgtcttg gacgtttgag tggttcccca agttccccac ctaccactgc 72240

tatttctgtc tattcattct ccttggccct ctggagttct ctcctgtctc ttctcatacc 72300

tggtcctgtt ctcctttctt tttcctccct ttcctccctc ccacccaggt ctttccttcc 72360

ctttgcctcc tgtgattatt ttgttccccc ttctatgtgg gagtgaagca tccacaagtt 72420

ggccttcctt cttgttaagg ttctatggtt tattatttat atgggggtat tctgagcttt 72480

tgggctaata tccacttatc agtgagtaca taccatgaat atccttttgg gtctgggtta 72540

cctcactcag gagtttattt gcctacaaaa ctcatgaagt tatcattctg tagagctcag 72600

tagtattcca ttgtgtaaat gtaccacatt ttctgtatcc attcttcagt tgagagacat 72660

ctaggttatt tacagcttct ggctattata aataaggctg ctatgaacat agtggagcat 72720

gtatccttgt tatatgttgg agcatctttt gagtatatgc ccaagagtgg tatagctggc 72780

tcttcaggta gatctatttc aaattttctg aggaaccaca gattgatttc cagagtggtt 72840

gtaccagttt gcaatcccac caacaatgga gaagtgttcc tctttctcca catccttgcc 72900

agcatctgct gtcacctgag tatctcagcc attctgactg gtgtgagatg gaatctcagg 72960

gttgttttga tttgcatttc catgatgact aaggatgttg aacatttctc taggtgcttc 73020

tcagccattc ggtattcctc tgttgaaaat tctctcttta tctctgtgcc ccatttttaa 73080

attgggttat ttggttctct ggagtctttc tttcttgagt tctttgtata tattggatat 73140

tagccctcta ttggatgtag ggttggtaaa aatcttttcc aaattaccag gttgctgttt 73200

tattctgttg tcctttgcct tacagaagtt tttcagtttt caaaatgaga tcccattttg 73260

tcaattgttg atcttagagc ctgagccagt ggtattctgt tcaggaaaat tttccctgtg 73320

ccaatgtatt caaagttctt tcccactttc tcttgtatta gattgaacat atctggtttt 73380

atatgcaagt ccttgatcca tttggactgg aactttgcac aaggagataa aaacggatca 73440

ttttgcattc ttctacatgc agaccaccag ttgaaccagc accatttgtt gaaaatgctg 73500

tttttttcac tgggtggttt tagctccttt gtcaaagatc aagtaaccat aagtgtgtgg 73560

gttcatttct gggtcttcaa ttctattcca ttgatcttcc tgcctgactc tgtaccagta 73620

ccatgtagtt tttatcacta ttgctctgta gtacagcttg aggtcaggga tgatgagtcc 73680

cctagaagtt cttttattgt tgagaattgt tttcgctatc ctgaattttt ggttattcca 73740

gaggaagttg agaattgatt gctctttcta tctctgtgaa gaattgagtt ggaattttta 73800

tggggattgc attgaatcca tagattgctt ttggtaagat ggccattttt actatattaa 73860

ttctacccat ccatgagcat gggagatttt tccatctcct gaggtcgtct tcgatttctt 73920

tcttcagaga cttgaagttc ttgtcttata ggtcttttac ttgcccagtt agagttaagt 73980

caacatattt tatattattt gtgactattg tgaagggtgt tttcttgatt tctttcttag 74040

cccatttacc cttagtgtag aggaaggcca ctgatctgtt taacttaatt ttatatccag 74100

ctactttact gaagtagttt atcaagtgta agagttctct gctagaattt ttggggttgc 74160

ttatgtatac tatcatattg cctgcaaata gggatatttt gacttcttcc tttccaattt 74220

gtatcgcttt gacctaattt tgttgtttaa ttgctagcta gaacttcaag tactatattg 74280

cataaataga gagagagtga gcagccttgg cttgaccctg attttactga gattgcttca 74340

agtttctctc catttagttt gatattggct actggtttgc tctatattgc ttttaatgtg 74400

tttaggtatg taccttgaat tcctgatctt tccaagactt ttagcatgaa ggggagttgt 74460

attttattgg aggctttttt cagcatttaa tgagatgatc atgtggttat tttttcattt 74520

gagtttgttt atatagtgga ttatgttaat ggatttgcat atattgaaca tccctgcatc 74580

cctgggatga agcctgcttg attgtggtga atgatggttt tgatgtgttc tttgcaagaa 74640

ttttattgag tatttttgta acaatattca taagcaaaat tggtctgaag ttctctttct 74700

ttgttgggtc tttgtgttgc ataaatatca gtgtaactgt ggcttcatag aacgaattgc 74760

gtagagtacc ttctctttct attttgtgga atcgtttgag aaatattggt atttggtctt 74820

ctttgaaggt ctgatagaat tctgcactaa aactatctgg cccagggctg tttttttttt 74880

tggggggggg tgggactttt aacgactgct tctatttcct taggggtttg gggactgttt 74940

agacagttta tctggtcctg atttaacttt cgttcctaaa tctgtctaga aaatcattca 75000

tttcatctag attttccagt aggcttttgt agtaggaact gaagattttc taaatttttt 75060

cagtttctgt tgttatgtct cccttttcat ttctgatgta agatgtttag aggtcaacac 75120

actgcttcac aaacaattac tcagtattca tgttgaccat gcatttcatg aagattatgg 75180

caaaaatagt gaaaaagaaa aaacacagag catatttata tatttaaaaa acatataaat 75240

accttcaact ttctttgatt tgaatgtggt cagatttgag cattttctaa ccagaatgag 75300

ctttggtttc caattgtttc tttagttagt taggcagcag gatcccacat agcccagaac 75360

ttctgatccc ttttcctcag ccttctgaag gcagggtgac aaacagactt gtgcccccag 75420

tgatgcaaca gatgagatcc agggctaggt gaagactgta ctcactgagt ataagaactc 75480

agaaagcact ctgctcactg agctaagaac atccttttca ccgagctaca gtccctgctg 75540

gatattatca taggttctat ggattgcagg gtgtttgggt atatgagtgc tcagacatgt 75600

gcgcgctcac acacacatac acacacacag ccataaccca tggcattctg tctctaccct 75660

gctttaactt ctctaagtct ttgatttaat ccaccttacc atcctttgca ttctcttgtc 75720

ttttgtcgac aatagagaca caggagaata acagatattt gggaactcat tccataggtg 75780

tgtgcagcct gcaaactcag tttccctgta cagaactgtg taaatgaaca caggtgtggt 75840

cttcaaaaca gcctcctcag ttagttacac aggaaggaac aatactggaa tggataaatg 75900

ctaaagggtt gcaggcgaaa cactggctta tagctcagtg ggtggagtgc acataactca 75960

gtggagagag tgcttgaggc agagtgggct gagtacttgt agctcagtgg gtagagtgcc 76020

tgtggctcag tatctagaat gcatatagct tagtgggcag agtgcttgta actcagtggg 76080

gagaatgttt atacctcagt tggtagagag tttgtaactc actgtgtaga ctgtctatag 76140

ctcacatggc atagtactta actcagtggg tagagtgctg gtggccgagt tggcactaac 76200

atgccccaag ggctgggctc catttcttac catgtaaatg gaaagccagt ctgcatccgt 76260

ggcatatagg agattgaggc tggaagacag gggtttaagg tcattgttag gggttggagc 76320

ccagagtgca agctgcctac ctgcttgctc tcacaaatcc tggtaagtct ttttcccaca 76380

atagagatac catgtggtgg tgtgggtgga atgagcacct cagttgattc tggcattttc 76440

tggatccaag tggagtcttc tctgctaaca cagggacctc atcaagaagc tgctggtggt 76500

ggacaggacc cgacgcctag gcaacatgaa ggtgagtcat gctagagcat tccagtttgc 76560

acactgacgg tgatgtcatc cactaagagg atcccagacc atgctcaatg ttaaattagt 76620

ttttggcttg tttgtttgtt gctggtttgt ttttattaat tctgtgtatg tactactcag 76680

gtttattacc tgccacagtg gactcaggtc ccctgcagct gcagttacag gagattgtct 76740

acttccatat agatgctgtg aatctaacct gggtcctctg aaagagcagc catctctctg 76800

gcccctattt gctgttttcc tgtagcccag actacaatca aaatcactat gttgtagcta 76860

aggataacct tgaacttgtg acccactcaa cctcccacct cccaggactg ggatgacatg 76920

catatgcctc cactcatggt tgacttattc tttatttttg agtatttatt tatttataag 76980

acagggtctc agtatatact tctgagtgtc ctagaaatct cttttgtaga ctaggctggc 77040

atcaaagtta tcatctgcct ccttctccag agtgctagaa ttaaaggcat gtgccaccaa 77100

acctggccac ttaatttatt tttaaattgc tttattggag attttagaaa tgatacacat 77160

gcacacgcac atacacacac actttttttt tcaaatgctt tttactgagt gtttatgttt 77220

cctctcaaga atggggcaga agacatcaag cggcaccggt ggttccgagg tgtggagtgg 77280

gaatctgtgc cacaaagaaa actgaaggtg ggagtattat acacccttga attaaatgaa 77340

cagcttcata tatggtccta accacccagt gagctcccac tactgtgtct cagtcttcca 77400

aattaattta ctagaggttt attgtcattt attttgcgct tgatgtatgt gtattgtttc 77460

tgtgttcatg cgcaccatgt gacttcagta ctggagtacc ttcagcctct cataaaattt 77520

gtattccaag tgacaggcat tacatgtccc cactgggcta cccagtgtca cctcattcac 77580

ttattttatt tctttgttgc tttgtttatt ttgaatgact ctcagccacc cattgtgccc 77640

aagttatcgg gtgatggtga catctccaac tttgagactt atccagagag tgaattggac 77700

aagacacctt ctgtatctga caaagacctg gaaacattca aaaatttctg aggatgagaa 77760

ctcatgtctg aaaggtaaaa cttttttttt ttctgaattt ctaagtaggg tgtcatgtag 77820

ccaaagatag cttttaattt accatgtagt tgagaaaata tacattcagt gcaactgaga 77880

atgatgaatt aaccagtctg cagggtttct tactatgtat gattgtcagg taactcagta 77940

gtaaatgttg ataatctctg aaccctcccc cttccttttc tttgccagat gtatgtgaag 78000

acatcgatac cacaccatac cacaccacag cacaacatac cacaccaatg gccagaacct 78060

tttttgtcgt acgtttccat ttcctactat gaaactagaa ggtttggtgt gtgtattcca 78120

gttcctgaaa gatcaataca atcatcaccc ttggaaccca gcctcatttc aacaactgga 78180

aacctgccca atgagaattc gcaaaacctg ttaaattgta ggttttctcc ttcttcatga 78240

gtcttgtgtt tgtgctgtga attttgtttc tttttttgtt tgtttgtctt tctactgaac 78300

tttttaagtt tgaatttgac ccatttggtt ttatggctgt cagtgtatat gtgcacagaa 78360

attgtgcaaa ctggaaattt tggcactttg tgcttgtgac atgttcattt tttaaagctt 78420

tctgaaaaat ctttcaccct acaggcaaaa aaaaaaaggg tgagatatat gctttttaaa 78480

aatgcctttc tatgcatttt gcaatcattt gtgtacattg tttatttagt tactgtttgt 78540

ttatttagtt cctttctggt cactttaaac ttggaagtca ggaagccaca tgccctgcag 78600

acccttattc agatatagca caaatgtgtg gctttcctcc aatcttccag tttagatgtt 78660

ttcagtaaaa tatcccttcc taaagttaag ccagaactct gcatacagca tggcacctgg 78720

gtgcaaagat tgccttttta tgataataca aatgtaccca catccccaca agggaacttt 78780

aaggatccac cccttaagcc cctccctcct ctgttgtaaa tggcattttc ttctcaccat 78840

cttaactttg ttctcccagc catgtccgtc cgtgaaaact caggttccag gccgggaact 78900

tctatgaaag tttgtacaga gctgtatttt tggtgagctt tctcagtgct ttccaatatg 78960

caaactaact gggttatgta cctcaaacaa acaaacacat acaggagata gaatgcagga 79020

ttataatcaa gtcctgtcag tagatgtttg ctattaagta ggaaataaca tgaaattagc 79080

ataggaaata ttgccttaat tctaaacaca catggggaga tcacacatgc gcacatgcac 79140

cctctgtgtg ctcctaaagc accttgcaat ctgactccaa tcctaaaaat caaataaaaa 79200

acccttaatc aggctgtaaa tcaaatgaca ctatgcgatg tcactacagt gacatcagac 79260

atcatatagg aatcataatt ttctatttta agatttttaa ttctgtgtgt acatgtgact 79320

gcagtacaca cagccaacaa gtgcaccaga gaccctacag ctggacttat aggcagttct 79380

atgccgccct gcggatgctg agaaccaacc caacctcgat cctctgcagt ccatgtagtt 79440

aacatgcaag aaggggtggt aaggcaaaag cagccatgaa aaagggtgag ggaaatatgt 79500

cctgttctta actctgagtc cagggagagt tgtgcaccca acaccttctc atgaaacaat 79560

ggaatagtta ataaatttca aatttctctg gtggtagctt gattcgaacc aaagtataaa 79620

agataatcac tagcaaataa aaatttaaaa acaaatttct gggctggaga gatggctcag 79680

cggttaagag cagtgactgc tcttccggag gtcctgagtt caaatcccag catcaacctg 79740

gtggctcaca actatctgta atgggatccg atgccctttt ctgatgtgtc taaagacagc 79800

tacaatgtac ttacatataa taaataaata aatcttaaaa agcaaaaaaa aaaaaaagga 79860

aatcccctct tttaaaaaaa aaaaaaacaa atctctatgc tcttcaacta agactgactt 79920

taatgtttag tacagataaa gtactacgtg ctgtggattg gtgcttgtct cactaaacta 79980

gctgttacat gttacactgt agaatgtgat ttgatggctt aatactgttc acaggaccct 80040

ctggctgtgc aaatatccca acattggacc aaaacatacc aatcaccact gtgttgctag 80100

gtgaacccta gtgaaaattt agcattgtgt gggtcttgat gttgaggtga aaatcacaga 80160

aagggtctca cttctgactg tagatttgaa atatgttgat ttcctgggat ttgtttgttt 80220

gtttttgtta ttgttttgga tgaagctccg taggaagcat ttgatgaaca ttcaacacct 80280

gtcattctta tttgtcagaa cactgtaaac cacctgaaac ttataatgca aagtcaaggt 80340

ttatgtgtga gttggtgccc ccattaggtt gtgtttgttc ccatcagttt agggggagga 80400

tctgcttccc aactgttaaa tgttactatc aaatctgcct ttgagtctca cacccttgca 80460

tctggcctca cagttatttg ggagagggag gttgctccag ttggttatgt aatagacatc 80520

atgacatcat tatctgtgtg acttagagaa agtgagcacc ccagcgctcc tggtcctcac 80580

atgtcagact aaaacccctt gtcacctccg ttcttctcag agtgtggggc tcatcacttg 80640

acctgctata acacaggtcc cacgtgcact gttcaggtgc accccccccc ctgctgccga 80700

gcaaccgtca gcttgcctga aattatgcag aatgaaaaag cctgtttctt tttccttttt 80760

tatcctgatg catattaaaa aaaatcactg tgatttgtgt gtatatctct ctatatattt 80820

gccccaggaa aactttctgc tgtctaattt ataaaatact attactgagt ccaggtttgt 80880

ttaataaaag tttgtatgtt ttaagaaatc tgtttcaggt cgtttcttga cttttcctgt 80940

aacacagggt aacaccataa aacacaagtc attgaccatg gttaatgacc tcagtgatcc 81000

agtcaccaac agtagttggt gcccatttct cagaggcaga actagtgaag ctgaaatgaa 81060

gttgggttaa tcaaggaaat tggtctgcac ccctgtaaca ggttgatgat tgttttgagg 81120

aatattagta cccaggatag tggaagtatt acaaacttca gacgtcatta acttggggga 81180

tgggggtagg gtggtgcata acctaagtca caagagtgtg ctatgtggga tttcttttct 81240

ggtccttata cgtttctgtg catctcttta tttttctttt acttttttta atgaataata 81300

tctttattta cattacaaat gttatcctct ttcccagttc ccctccccag aagcccccta 81360

tcccatccct ctaccccctg cttctatgag ggtgttccct cacccaccca ccaactccta 81420

cctccctgcc ctcgattcac ctacactggg gtatcgagcc ttcacaggac caagggcctc 81480

tactcccact gatacctaac aaggccatcc tctactacat atgcggctgg agccatgggt 81540

ccctccatgt gtactccttg gttggtggtt tagtccctgg gagctttggg ggatctgggt 81600

ggttgatatt gttgttcttc ctatggggtt gcaaacccct tcagctcctt cagtcctttc 81660

tctaactcct ccattgggga ccctgtgctc agtccagtgg ttggctgtga gcatcgcctc 81720

tgtatttatc aggctctggc agggcctctc aagagatagc tatataaggc tcctgtcagc 81780

atgcacttct tggaatccac aatagtttct gcatttggtg actgtatatg ggatagatcc 81840

ccaggtgggg cagtctctgg atgacctttc cttcagtctc tgcttcatac tttatctcca 81900

tatttgctcc tgtgagtagt ttgttacttc atctaagaag gaccaaagca cccacacttc 81960

ggtcttcctt cttgagcatc atgtggtctg tgaattgtat cttgggtatt ccgagctttt 82020

gggctaatgt ccacttatca gtgagtacat accatgggtg ttcttttgta tcttggttac 82080

ctcactcagg atattttcta gttccatcca gttgcctaag aatttcatga aattattgtt 82140

cttaatagct gagtggtact ccattgtata aatgtaccac attttctgta tctattcctc 82200

tgttgaagga catctgggtt ctttccaact tctagctatt ataaataagg ctgttatgaa 82260

catagtggag catgtgacct tgttatgtgt tggagaatct ttggggtatg tgctcaggaa 82320

tggttctctt agttttaatc tattggtttc tgccctgact ttgatcattt cctgctatcg 82380

ctcctcctgt gtgtgtttgc ttcttttttc taaagtcgtc agatatactt ttaatatgtt 82440

agtatgagaa ctctccaatt tgtttatgga ggcatttggt gctataaact ttcctcttaa 82500

ccctgctttt agagtgtccc ataagtttgg atatgttgtg ccctcatttt cattgaattc 82560

tagaaagtta ttcattcctt tcttttctct gaccccagtg atcattgttg ttgttcagtt 82620

ttgatgagga gtatgtggac tttctgttgt ttctgttgtt gttgttgttg ttgttgttgt 82680

tgttgttgtt gttgttgaag ttcagattta atccatggtg atctgatagg atgggattat 82740

ttcaatcttc ttgtatctgt tgagacttgg tttgtgacag actatatggt cagtttcgga 82800

gaaggttccg tgaggtgctg agaaggtata ttcttttgta tttgggtgat agatatatgt 82860

taagtccatt taaatcataa cctctgttag ttttgttatt tctctgttta gtttctgtct 82920

caatgacctg tcaattggta agagtggaat ggtgaagtct cccactatta gcgtgtggga 82980

ttcatgtgtg attaatcttt agtaatgcat cttttacgaa tgtgggtgcc tttgcatttg 83040

aggcatagtt gttcagaact gagatgcctt cttggttgat tttcctttag tgagtatgaa 83100

gtattcttcc tggtcatttc tgattgcttt tggttgaaag tctgttttat tagatattaa 83160

aatggctagt ccatcttgtt tcttaggtgc atttgcttga aaaacctttt tttcagcctt 83220

tattaatatc tatctttttg ctgagatgtt tcttgtgtac agcagaatga tggattctat 83280

ttacacatcc attcagctag cctgcgtctt ttaactgggg aattgaatct atggatgtta 83340

agagatatta atgatcaatg attgttataa ctttctgtta ttttgatggt ggtagtggtg 83400

gtagtatgtg tgtgtgtttc tcttctattt taatggtgtg gatctattta tttatttatt 83460

tatttattca ttgtattttc tttagtgtag ttagcctcat tgggtttgac ttttccttct 83520

agtatcctct gaagggttgg gatagtggaa aggtagtttg aatttggctt tgtcatagaa 83580

tatcttagtt tcttcatcta tgttgactga aagttttgct ggggcagtga gccccgtctg 83640

ccagaccttc aaggttccac catgttctcg aaggtgagta ttgtcaggct gtcggcctgt 83700

gccacgcagc cgcaatggat ccaagtttga aacatggcaa ctctgaaaga tattaccagg 83760

agactgaagt ccatcaaaaa tatccagaaa attaccaagt ctatgaagat ggtggcagct 83820

ataaagtaca cccgggctga gcgggagctg aagcctactc aagcgtatgg aacagggacc 83880

tgaggacaat aagaagcacc tcattattgg tgtgtcctca gatagagggc tttgtggtgc 83940

tattcattcc tcagtggcta aacagatgaa gaatgaagtg gctgccctca cagcagctgg 84000

gaaaaaagtt atgattgttt gagttggtga aaaaatcaag gtcatacttt ataggactca 84060

ttctgatcag tttttggtgt cattcaaaga tgtgcgacag aagcccccta cttttggaga 84120

tgcaccagtc attgcccttg agtttttaaa ttctggatat gaatttgata acgactctat 84180

catttttaat cagttcaagc ttgttatctc ctacaagaca gaagagaaac ccatcttctc 84240

tctcaatacc attgcgactg ctgagaccat gagcatttat gatgacattg atgctgatgt 84300

gctgcagaat taccaggaat acaatctggc caacctcatc tactactccc tgaaggagtc 84360

caccaccagt gagcagagtg ccaggatgac tgccatggac aacaccagca agaatgcttc 84420

tgatatgatt gacaaattga cgttgacttt caaccacacc cgccaggatg tcatcacaaa 84480

ggagttggtt gaaatcatca tcatcatgct gctctgaatt aatgaaaatc aagttgtatc 84540

ctcagacaag aggtaaagaa gaagaatgtg caggctgatt ttaactgatt gctatctttg 84600

tcagaagaaa cttggtccac tgagttacaa agatagcagg atgtttgttg agaaattggg 84660

tgtaagtata atatatccat ctttatattt tacttggcct ttttcccttg cagcttttaa 84720

tattctttct tctatatatt tagtgttatg attattatgt gacaggagga ctttcttttc 84780

tggtccaatc tgtttggtgt tctttaggct tcttatacat ttatatccat ctctttcttt 84840

aggttaggga taatttcttc tatgattttg ttgaagatgt ttctggacct ttgagctggc 84900

aatcttctcc ttcttctatt tctattattc ttaggtttgg cttgttcata gtgtcccaag 84960

tttcctggat gtttcgtgtc atgaactttt tagattttgc attttctttg acataaatat 85020

tgatatctac tactactact gactcatctc ttgtattctg ttgatgaggc ttgtatcttt 85080

agttcttgtt ctctttccta ggttttccat ctccaggatt tcctcagttt gtgttttctt 85140

tattgcttct atttctcttt taaagtcttg tacagtttta ttcatatcct tcacctgttt 85200

ggtcggattt tcctgtcttt ctttatattt atttgcttcc ttgtttaatg cttctaactg 85260

tttgaatgta cttttctgta gttgtttgtt tgtttgcttt tcaagacagg gtttctctgt 85320

gcagtcctgg ctgtcttgga actctgtaga ccaggctggc ctcgaactca gaaatctgcc 85380

tgccaccacc tcccaagtgc tgggattaaa ggtgtgcacc accactgccc ggcttctgta 85440

tttctttatg ggatttattc atgtcctctt taaaggcctc tatctttata agactggatt 85500

taagatcctc ttcttgtgtt tcagtttcct tagggtatac agggtttgtt gtggcagcac 85560

agctgagctc tggtggtgcc atactaccct aggtcttgtt ggttgtgttc ttaagctagc 85620

ttttaggcat ctgcttttcc ctggtgttgg ctgtatgatc ctgatgccag caggacttct 85680

ctggaagatg ggggagccat agtacagaca atggaggtca ggttacacaa ttctgggggc 85740

tgtgcctgag gtggacccca ctgataaggg attggtggag caatgctcca acctggaagt 85800

tcttggggtt tccacaggcc tccacataga aacaggatgc tcttgaggtc ccctaaggct 85860

cttcaggact gaagagcaag cccagaacta ggcagtagag ttcaggggac tgtgcacaac 85920

tctgcctgct gtatcccagg tggacccaac tgagaaggga ttggtggagc aggtttccaa 85980

gctggttagt tttggggtct ggaagtcttc cacaggaaag catgacagtc ttgggatcct 86040

ccaaggttct gtcaggactg aagagctaat tcagagttag ataatcaagt tccctttgat 86100

ttttcatgtg acttttttgt ataacataca tttacattta ttaatgaata tctctaaaat 86160

cagcaaccat taaaaagtga ttgcattatg tggtcaagca gaactagcaa ctttcgtttt 86220

ttaaaaagca caaatcttaa aaatctcaat ttattcacat acataataca gcatactagt 86280

tatgttaaat gctacaaacc aatgtgagtc taatcggatg gggaaaagca cacatttaag 86340

ctttaagaaa catttttccc tatatattag cattttctta aatacataca tgagataaat 86400

gaggtaacta taaaatatac agggaacaac catccatctt gtgtatatgt atatgtatat 86460

gtatatatat atatatatat ttatatttat atatatatat atatatatat atatatatat 86520

atatatacac acacacacat gcatacatac atctataaaa cctttctaac acagaaaaca 86580

gtgctgggcc cacattgtta ggaaaagata actactatta tgactaggcc agaagttggt 86640

aaataaagag taaacaatgc caagccccca ccacaggaaa ccattggtaa catggagtct 86700

atagcaaggt cagcaaatca caaacatcct aagtaattgt gttccaagat atttgatcac 86760

attgtgaacc ccaagattgt gaactggaaa aaaaaaaact ttcttgttgt tgtatggctt 86820

agccctagca cacaccttta acccaagagc tttctttttt tgttgttgtt tctttttttt 86880

tccatttttt attaggtatt tacctcattt acatttccaa tgctatacca aaagtccccc 86940

atacccaccc acccccactc ccctacccac ccactccccc tttttggccc tggcattccc 87000

ctgtactggg gcatataaag ttccaagagc tttctataaa taagagctaa ataaagtcaa 87060

ctgtaggtca agaggcagag caaacaacca attgagagag agtgaacata gaaagtagaa 87120

tggacggaca ttgagttgaa ggttatttaa gacagtataa agaaggaaaa ggaacttttt 87180

ccttctggga cactggtgga atagaaaggt caactgggtg cttttttctg cctctctgaa 87240

ctagcaggct ctcatcataa tgtctggctt ttgagtcttc atttggcaaa tagaacattt 87300

gggattctgt ttttaaaaca acataactgt ttcataatta gtttttaaat aattttaaaa 87360

agtgtatacc cctcagacct gcttgttggt attactgtag ccaacacaat ccatgagcca 87420

attctgctgt cccagggttt caaatcacag ggtttgaatt tttttgttgt tgttggagtg 87480

aggaagagat agaggttgga gaaggtggtt ctctgtgtaa aacaggtaga taaatatagt 87540

gtaaccatca cctggttaca tacagtaaac tttaggttct tgtagggtgg gccaatgggc 87600

ccctggcagg ctgggtggga tgcaggaaac ctgggctgct gcatgagaat ggggtttgtt 87660

ggaacaggcc tgctatcagg tgctggcccc acaagtggtt tattcactta gggcaacaac 87720

cccagatggg gataggaaag gaaataaatg ggacttgaaa gtgtagggaa ctcagacttc 87780

tccagacctt gagggcagga gtcaggccag gaagggccat aagatagagg ttcatgccct 87840

ccttgtctct gtccttatgg gattcctagg agactcaccc aggcaggtga gagacaggcc 87900

ctgactggag aggaaatgcc ttgaaaatca aacagtcctg gtagtctcat gtgacttata 87960

aacactttta ttaaaacact cccttggttt ttcttttctt tttaagattt atttattatt 88020

atatctaagt acactgtttt agctgtactt cagatgcacc agaagagggt gtcagatctc 88080

atcatggatg gttgtgagcc accatgtagt tgctgggatt tgaactcaag accttcggaa 88140

gagcagtcag tgctcttaac cactgagcca tctctcatca caggtttttg tgtcttaaat 88200

gctgtcttgt tacataacca gagtggtctg aagctcagat tggcattaga cacactgttg 88260

tcttcctcct accaaggctt tgcagctgga gttagggatg gttgtaaact actatgtggg 88320

tactgggagt caaaccaggg gcctctacta gagtaaccag tgttctttaa aaatgattta 88380

tttatttgtt ttatataagt acactgtagc tgtcttcaaa tacaccagaa gagggcatgg 88440

atcccattac agatggttgt aagccatcat gtggttgctg gggattgaac tcaggacctc 88500

tggcagagca gtcaatgctc ttaaccactg agtcatctct ccagcaccta aatgctgaaa 88560

ttctaatttg taccttccct acaaaggtag aaacaaatgc taatgtatgc tttgtatgaa 88620

ttattgtgac tcagaatgag gtagttgact gtgtcttgca agcccgaggc cctacctttg 88680

atcttcagtg ccatacagaa acaaaacaaa cgtattaaag agtcctcaga ttttcagtag 88740

ctcccctttc tgcctctata catgtggcca tagattggat tggacaaata ggcagatgga 88800

gaccctgtga ggggtgagat gagcaaaatt attctagaag tagtacaggg ggtacactaa 88860

ggctgactgg tctttggggt aaaatggttt gttataccac agaaagacag caaggcaaga 88920

agagctcttg aggggaactc tggtccatgt gggaaagtag gaatccctcc ttgtacgctt 88980

aggaggaggg gtaaaaatcc atgctacata cacaaaagat tttatgcttg taactgacat 89040

gattgcagta gttcccacag accaccttca ctgcaagaca gaagttctaa gcataggctg 89100

tgatctgcag aaaggaccct tgacaatgtc aaatgacagt tttgcttcca ctttggagaa 89160

ggcatttttc ccaacatgga gaggtatcca ttgcttctca gaattctaga gtgcttagaa 89220

tggccttgct acttgcaata tgcccaaggg tccttactct caactccaga aactctctgt 89280

atgactatta tcaacaataa tattaaataa tgcattacta ttatttattt gtctaaattt 89340

ttattgaatc tctatatagt atattccatc tatttacctg tcaatattta tctcattttt 89400

ttctcttgaa aatatttctg tgcatcaatg tttttcttgc aggtatgtat acctagtgcc 89460

gatatagact gtaaggatcc catggaattg aagttgcaga tggttgtaag aggccatgtg 89520

gaggctgtaa atcaagcctt ggtcccacag aagagcagca aatgcatttt aataggtgat 89580

ccatcagtcc aggactcatt cttccctttt ctatttgagg gagcatctgt aagcctaaag 89640

gggccttgaa gtcacaatcc tcctgtctca gcttccaggg gactgggagt gtagttgagt 89700

ctgctctaac taaacttaac aggcttttat ggtgcttagt gccaataagt aaaatgatgg 89760

agatgagaaa atgaaaagag cccagagcag aagatagatg cccaaggcca acccagattt 89820

aaatatggat taggctcagg aggccagggt acatttacca tgctagaggc tcatcagggg 89880

ctatagacac ctgttgtgta ctggatctga tcctggattg ggtccacaag tgctctggaa 89940

ttttttttaa ttaggtattt tcctcattta catttccaat gctatcccaa aagtccccca 90000

taccctcccc cccattctcc tacccaccca ctcccacttc ttggccctgg cgttcccctg 90060

tactgaggtg tactgaggca tataaagttt gcaagtacaa tgggcctctc ttcccaatga 90120

tggccgacta ggccatcttc tgatacatat gcagctagag acacgagctc cggggtactg 90180

gttagttcat attgttgttc tacctatagg actgcagatc cctttaggtc cttgggtact 90240

ttctctagct cctccattgg ggaccctgtg atccatccaa tagctgactg tgagcatcca 90300

cttctgtgtt tgctaggctc cagcatagtc tcacaagaga cagctatatc agagtccttt 90360

cagcaaaatc ttgctagtgt atgcaatggt gtcagcgttt ggaggctgat tatgggatgg 90420

atccccggat atggtagtct ctagatggtc catccttttg tctcagctcc aaactttgtc 90480

tctgtaactc cttccatggg tgtttagttc ccaattctaa gaaggggcaa agtgtccaca 90540

ctttggtttt cattcttctt cagtttcatg tactttgtat cttgtatctt gggtattcta 90600

agtttctggg ctaatatcca cttatcagtg agtacatgtc atgtgagttc ttttgtgatt 90660

gggttacctc actcagaatg atgccctcca ggtccatcca tttgcctagg aatttcataa 90720

attcattctt tttaatagct gagcagtact ccattgtgta aatgtaacac attttctgta 90780

tccattcctc tgttgagggg cttctgggtt ctttccagct tctagctatt ataaataggg 90840

ctgctataaa catagtggag catgtgtttt tcttaccggt tggaacatct tctggatata 90900

tgcccaggag aggtattgct ggatcctcca gtagtactat gtccaatttt ctgaggaacc 90960

accagactga tttccagagt tgtacaagtt tacaatccca ccagcaatga aggagtgttc 91020

ctctttctcc acatccttgc cagcacctga attcttgatc ttagccattt tgactggtgt 91080

aagatggaat ctcagggctg ttttggtttg catttccctg atggttaagg atgctgaaca 91140

ttttttcagg tgcttctcag ccactcggta ttcctcaggt gagaattctt tgtttagctc 91200

tgagcctcat tttttaatgg ggttttctga ttttctggag tccaccttct tgagttcttt 91260

atatatgttg gatattcgtc ccctatctga tttaggatag gtaaagatcc tttcccagtc 91320

tgttggtggc ctttttgtct tattgacggt gtcctttgcc ttacagaagc tttgcagttt 91380

catgaggtcc catttgtcaa ttctcaatct tacagcacaa gacattgctg ttctattcag 91440

gaattttccc cctgtgcttt tccccacttt ctcctctata agtttcactg tctctggttt 91500

tatgtggagt tccttgatcc acttagattt gaccttaata caaggagata ggaatggatc 91560

aattcgcatt cttccacatg ttaactgcca gttgtgccag taccgtttgt tgaaaatgct 91620

gtcttttttc ccattgcatg gttttagctc ccttgtcaaa gatcaagtga tcataggtgt 91680

gtggattcat ttctgggtct tcaattcttt tccactggtc tacttgtctg tcagtatacc 91740

agtaccatgc agtttttatc acaattgctc tgtagtacat ctttaggtcc ggcatggtga 91800

ttccaccaga ggttctttta tccttgagaa gagtttttgc tatcctatgt tttttgttat 91860

tccagatgaa tttgcagatt cctctttctg attcgttgaa gaattgagtt ggaattttga 91920

tggggattgc attgaatctg tagattgctt ttggcaagat agccattttt actatatcga 91980

tcctgccaat ccatgagcat gggagatctt tccatcttct gagatcttct ataatttctt 92040

tcttcagaga cttgaagttc ttttcataca gatctttcac ttccttattt agagtcatgc 92100

caaggtattt tatattattt gtgactattg agaagggtgt tgtatccctg atttctttct 92160

cagcttgttt attctttgtg tagagaaagg gctctggaat ttttacatct tccagtgggt 92220

ttagcagagt ccataaacct aggctggtga ctagatccaa cattgggtta ggtcatcctg 92280

gtctacagaa tgagttccag gacagccaga gctacatagt aattccctgt ctcaaaaaaa 92340

aaaattaaaa agaaagaaac aaagaaagaa agaaagaaag aaaggaagga aggaaggaag 92400

gaaggaagga aggaaggaag gaagagagaa agaaagaaca acatgagtta gggaactgta 92460

gagctggctt tctaatgcaa acacttacac tagatctaaa gctctgacta tagtccccta 92520

aaccttaaca tgacaaagta tacactcata cacctagacc cagacctacc ttacatctca 92580

aagataattt acattcacaa gtattgtaat tgaatgctac aggaaaaaat ggacaaaata 92640

tgaaacctat cagattttgg tataaaaatc aattttaatg ctttcactaa ccctaagacc 92700

atgaccataa tcccctaatg ctaatcctaa ccttaacaca gcagaccaca aaacactcct 92760

tacttataaa aaaacaaaac taacataacc ttaccttgca tcatagacat aacttatatt 92820

aagagacatg gtaacttgat gttaggtcaa aaaaaatggg atagattatg aaacctattg 92880

gatttgggtg taaaactttc ccaaatatca agattagaaa ctcaggtttt gagaagcatg 92940

attgaatctt ttttgaggca ataaaaaatt taaacctgga ggatgatggt ggcatatgcc 93000

tagaatccca tcactccgga gacagaggca gatggaactc tatgagttcg aggacagcct 93060

ggtctataga atgagttcaa ggacagtcag agccacacaa agaaaaacct gtctcagtaa 93120

aatcaaaaaa caaaacacca aaaaacccac cactgccact accaacaata aataaataaa 93180

taaataaata aataaataaa taaataagtt taaacctgcg gttactagac taatgggtaa 93240

ctctatgatg ctttatagct ctatttcctt gagtcagaat gactggagaa gtgctctgca 93300

gattccagat ggaatgaaag ctattaacct agaaatggta cactgaggca aaggaaccca 93360

ggcagggtgg tagagtgaag aaattgcagc catagaagtc tctacaccaa aggtgaagac 93420

taaggagcag cactcaacat ctatagggtc ttgggggccc cttgagttcc tacaaaatgc 93480

ctctgcctca taaacaatat gtttgtctgg aagtcagcta ctttcagccc cctatcataa 93540

aacgataacg gaacctgcca tgtccaggtc tgtctgacat gcagaagtcc aagtaacaag 93600

atttggctat acacttctta aagattctct gtctcgctgt ctctctgtct ctgtctgtct 93660

ccttctgtct ctgtctttct gtgtgtattt atatacaagt gtgtgtgtgt gtgtgtgtgt 93720

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgg tgagtaccta tttactgact cttgggcctt 93780

agtaaaatat attgcaatct gctctaaaac tagaaggcaa gtttttacaa tcagtagata 93840

tttgttctaa agaggcctgg atttttaaag caaaatctga tatcaaaata tctgtgaggg 93900

aggcatgaca ctagcaaaga tatagaagaa gccagacata ataataccat tatgatcaac 93960

tatccaagat aagtgccacc agatataaga ttaacaagga acaaatacct agaaccagaa 94020

tcaaagggga aaatgacaca tgggaataaa tactacctac cattaagcta cagaagatca 94080

cttgtgttta ttgccactat accaaaaact aggacatcaa ggaacacaag gactaaaaca 94140

ctgaatagac taatgcaata ttcaggaatc ctggcatgtt attaagaata ctattagcta 94200

gatggttgtg gaacacacct ttaatcccga cactcaggag gcagaggcaa gagactctct 94260

gagtttgaga tcaccctggt ctacagagtg agttccagga gagccagggc tacatggaga 94320

aactctgtct tgaaaaacaa acaaccaaat actattaaag gttgtgaaaa aagttctcac 94380

ggatactttt taactagata caactctatt ggtaaggcta cacactgtaa gatatatgta 94440

tttaactata caatacaaat acacttcgta ggaccattga tcaaatatag aagtaaatat 94500

acatgcacaa tggcaaacac ctttatagga ttaggcattg tagtgcgcat accctactca 94560

gcaagcctcc atgaacaatc tttggttctg gtacacagcc tttgattgtc ctaagtttat 94620

aatagactct gacaaaggct catacttcgc aggcaaaatg acacaagaaa cggcaaataa 94680

ttagatatct aatggaattt ctatatacca tatagcccta gaacatcagg aaacatgaga 94740

gatgcaatgc tttgatcaaa gaataattaa tgttgtctgg ttaaatttac ctgcaattgg 94800

cttttattaa taaagcagct tataccctga cccagctggg acttagcctg tctatattgg 94860

cttgttcttt tccaaaatct ggacttcagc aacatctcca ataaaacctg gagatattaa 94920

gcactgacta cactatttgc ttcagtggca cattggttga aagatgaaat gaaagataaa 94980

ggtggcattg ccaccttcaa atcaatgttc tcacaactta gtgggacata gtataagact 95040

aatttgcaca ggccctaatt ggtctaaagc agctctcatc actctttgtg actttactac 95100

cttaattaag ttttatcagt tccattcact ttatatgcaa attgtttttg agatttggcc 95160

tctcagacat atttaagtta ggagaagaac taccagatat accattattt gaaagcataa 95220

taacctttct agaacttata aacaaattta ctatacaacc tcatattggg agcagatttt 95280

gttttggtcc tggaagacaa agaatggaac tagatcttaa gacgtaatgg tagatacaca 95340

ccccttcact ctcttcacac tttatattgc cttaattgta gtcttactca gttttgaact 95400

ggctctatat caaatactat gaacacctct ctccaagcac cacgcaccta ctgggataca 95460

acacactaac atttagaaag aagtggatca aacctctctt tgtgttgatg ataggtagaa 95520

ggccctcttt gaagctacta ccactactgt cactgtagcc atctggacct agctcactat 95580

attcatttcc ccagaactcc ccaatattgt aggatggaag gacttaatgt aaccatcaga 95640

cttgataata acaatagccg cctattggaa tgttacagaa ttggcacata aacctgttgt 95700

cttaggatct ccattgctgt gaagagacac cacagcaact tttataaagg atatcattta 95760

attggggctg gcttacaggt tcagaggttc agactattat catcatgatg gaaaacatga 95820

caacatccag gaagaaatga tgctgaagtg gtaactgaga gttctatatc ttgatccaca 95880

gacagcagaa gactgatgtg acacactggt cagacttgag ctttttagac ttcaaagctc 95940

atacccagta gcctacttcc tccaacaagg ccacacttac tccaacatag ccacacatcc 96000

ttattgtgcc acttcctatg accaaacatt caaacacatg aatctatgtg ggccaccaca 96060

cctgttgaga tgcacatgat aataaatgca aacaggctat gcagaatagt aagcatttta 96120

actcacaact taagagcttt accaacctag acaaatgcaa taatcctact aaagcctcta 96180

gcaatactaa ttgttgaaaa taactggagg attacagaaa ggcacaaaaa agcaatttat 96240

gcagaccact ggatatactt agaacaaatg gagctcttgt ctctagctgc atatgtatca 96300

aaagatggcc taataggcca tcacttgaaa gagagatcca ttggacttgc aaactttata 96360

tgccccagta caggggaacg ccagggccaa aaagggggag tgggtgggta ggggagtggg 96420

ggtggggtgg gtatggggga cttttggtat agcattggaa atgtaaatga gctaaatacc 96480

taataaaaat ggaaaaaata aaaataaata aaagagtaaa aaaaacataa aaaatcaatg 96540

ttgatcaaca catttcgtct gctaagatgc cctacctaca agatgagttt ttaattattc 96600

caagctggta ctctgatgga actcttacaa gtaacacagc tatggaagtc agctttatac 96660

taattctggt acccatatgg gatggaaaag ataaggacta taaatatgta gaaactgagg 96720

tatccaacaa taaggatgac acagcaacaa taacaaccaa accatatttt aatcctctca 96780

agccatattt taatccatct aatgacagta tatccttcat atttagaata caagaaggaa 96840

cagatttaaa aagaaatgag caatgagagt atatattatg ttttaggctt cattaatttt 96900

ccatactttg gacatctctc tctctctgac cacccatgag gtgaaggagt tcacagaagt 96960

ctcatcttgg gacagctgat ctctaatacc tcttaatccc ccatcattat gggattctaa 97020

tacttttgga atatattggg acatatacca attcccactt gtgcctactg aacccaaatg 97080

tctgccctac tctttagaaa gattacaaca aaagtcttta agacagaacc aggcacttac 97140

tctcctaaat tcctatccca ttatttcata ttattagaaa ccaagctagt ggcacatgta 97200

aatttaattt tatcacagcc ccaaactata actctacatt gcctaacttt gaaatgattt 97260

gtgtatgttt agaattaaaa caaaaccttc cacttttacg gggtcacaat tggacaatat 97320

ttggggcaat caacttgtag aaaactggtt agcttaggca gaaaatcgca actctaaaat 97380

cactgtccaa cacagatgga acatgtctgg agaagtgtat ctcctagtgg tatggggtgg 97440

tactacaatg agatgagcac tcatactact ttggctcaat gtaacaatcc tggctgacaa 97500

acataatcca gcaatagtca aaacactatc aaaagcatct agtttgatac atcaggcatc 97560

aaatatacac agtgatcaaa tatatacagc tatcaccaac agttaatcag gaactcaaat 97620

ccatttaatt tgatgttggc tattggcttg ctgtatattg ctttgattct gtttatgtat 97680

gtgccctgta tccctgattt ctctaatacc tttaacatga aggggtattg gattttatca 97740

aagtcttttt cagtgtctaa tgagataatc atgtgatttt ctttgtttat atggtggatt 97800

atattgatga tattaatata ttgaatcatc tctgcatccc tgggatgaag cttacttgat 97860

catgttggat gatggtttta atgtgttctc tgattcagtt tgctaatatt ttattgagta 97920

tttttgcatc aatgttcata aaagaaatta gtctgagaat cttttgttga gtctttgtgt 97980

ggtttaggta tcagggtgac tgtagtcaca caaaatgagt ttggcagtat tctttctatt 98040

tccattttgt ggaatagttt gaggagtgtt ggtattaggt cttctttgaa agtctggtag 98100

aattctgcac taaaaccatc tggccctggg ctttgggtgg aggattggga gacttttaat 98160

gactgccccc ccacacttag gggttatagg gctgtttaaa tagtttacct gatcttgatt 98220

taactttggt aagtggtatc tgtctagaaa attgtccatt tcactgagat ttccccgttt 98280

tgtggagtat aggcttttga agtaagacat aaaaattctt ttaatttcat cagtgcctgt 98340

tgttatgtct cccttttcat ttctgatttt gtttacttgg atactgtctt tctgtctttt 98400

ggttagtctg gctaagggtt tgtctatctt gttgattttc tcaaagaacc ggctgctggt 98460

ttcattgatt atttgtactg ctttctttgt ttctaaatga atgattttag ccccaatttt 98520

gattatttcc tgccttctac tactcttagg tgtacttgct tcttttttct atagctttca 98580

ggtgtacttt tttaaactta attttatttt ttacttattc actttacatc ccactcactg 98640

ccccctccca cagtccttcc cccatccccc ttccccttct cctctgagca gttgggagcc 98700

ttcctggcta tctcccaatc ctggcacttc aagtctctgt gaagttaggt gcttctccca 98760

ctgaggccag tcaagggagc ccagctagaa gaagaacata taccacatac aggcaacagc 98820

tcttgggata gcccctgctc cagttgtttg ggacccacac aaagaccaag ctgcacatct 98880

gctgcacatg ttggggaggc ctaagtccag cctgtgtatg ttctctttga ttggtgttca 98940

gactctgaga gctccaagag tccaggttat ttgctctgtt ggtctttctg tggagttcct 99000

atccctttct gggccacaat ccttcctcct agtcttccaa aagagtcccc aagctccatc 99060

cactatttgg ttctgggtgt ttgtatctgt ctgagtcagc tgttgggtgg agcctcccag 99120

aggacaatat gcacctgtgt gcaagcataa cagagtacca ttaatagtgt tagggattgg 99180

tgcttgtcca taggatgggt ctcaagttgg gccagttatt ggatggccaa ttcctcaatc 99240

tctgctccat cccctgtccc tgcatttctt gtggaccgga cagattttgg gttgaaattt 99300

ttgtgggtga gttggtgtct ctgtcgctcc actggattct tgcctggctt caggaggcag 99360

gttccatatg cccaattttg tgagtcacag ctaaggtcac tcccattgat tcttgggtgc 99420

ctcccttatc ccaggtctct gtcttgtcct ggagatgccc ccccccatct cctcatcctt 99480

gtcagttgca aagtttttta tggtttaaaa tattactttt actaaaatta aagcatgcta 99540

tagaatacca ccataagata tttagaattg tgtgtgttgt ttgcttgctt tgtccttctc 99600

aatgtctttg gctatggcag gtatcaaatg aggaaatgaa aatgatttgt ataaaaatat 99660

gcttttgata agacttttta gatggaggag agttgctggg tattaaacca gtgcctcatg 99720

cagactattt cctctgcttt tgaaaaaaaa aaatcttaaa aacatctttc atcccttgta 99780

aagctcctaa aatgtagata tatcatatac ttatctgggc aatgatttca tctgatttgg 99840

aattctatca atagcaagtg atggttaatt catgtcccaa aatcaaagag gatcaggaat 99900

atatatgtgg ctagtaggag agatcttgcc cagagtgtga gcctagaata tcaccacaag 99960

cctcacagca aaagagaaaa tggcttcaaa ctgaatctta aatgactaaa tacttaacat 100020

ctgaaatgat tgagaatttg tgcctagggg aaacatagtt ctacataaat tataaaatta 100080

ttcatggaac ttgttagaaa aaaaatttca tgctacataa gacacaagcc atgaaaacca 100140

tatagcttta cagctaaaat gatttaaaac aatttttaaa atacttaaaa attataaagg 100200

gagagattgg ttaagagcac aaattgctct tccaggggat gcagtttcta atttcggcta 100260

ccagatggtg actcacacct gtctggccac ttcagtggat ctgctgccct cttctggcct 100320

tcttgagcac cagacatgcc catagtacac atggtaccaa acacccatac acttaatttt 100380

cttaataaat aaaaagaaaa cctagagtca taaatatgaa agaaaaatga ttgtaagatg 100440

aatttttgga tatttgattc catctcactt taatgtacat tcccagaaat cattttacac 100500

cctaaaaaaa gggagcatat actactagat agtaaaagct ttaagagttt ggaaatagat 100560

ctcactgtta aagcatttgc ttagcatgca tatgactttg gattcaattc tcagcactga 100620

aagaggctct acaagaaagg aaaatacaaa ctgcattaag atgagacatt aaagttcatt 100680

tctatcaaat tcattaatta tattagtctt ttttttcaat gctaaggatt gagcccaagg 100740

aagaattatt tcactcagat gagttttctt taaactttgc tactaaagat tcaaatactg 100800

ggctggaaat atggtctggt gacatagtgt ttacccagca tgtttggttc ctgaatttga 100860

tccttagtag cggcactttc cccttaagta accctccctt cgaggagagg cccttggtcc 100920

ggtgaaggtc ctctgccaca gtaaagggga atgccaggtc caggaagtgg gagtgggtgg 100980

gttggggagc acggggagga aggagcggat agggggtttt cagaggggaa gccaggaaag 101040

gggataacat ttgaaatgta agtaaagaaa atatctattt accctttctt agaaatggga 101100

acaaaacacc catggaagga gttacagaga caaaatttgg agctgtgacg aaaggatgga 101160

ccatctagtg attgccatat gcagggatcc atcccataat cagcttccaa acgctgacac 101220

cattgcatac actagcaaga ttttgctgaa aggacccaga tatagctgtc tcttgtgaga 101280

ctatgccgga gcctagcaaa cacagaagtg gataatcaca gtcagctatt ggatgggtca 101340

tacggcccct aatggaggag ctagagaaat tacccaagga gctaaaggga actgcaaccc 101400

taataggtgg aacaacaata tgaactaacc agtaccccgg agctcttgac tctagctgca 101460

tatgtatcaa aagatggcct agtcggccat cactgcaaag agaggcccat tggacttgca 101520

aactttatat gccccagtac agggaaatgc cagggccaaa aaggggcagt gggtgggtag 101580

gggattgggg gggggtgggt atgggggacc tttgggatag cattgaaaat ctaaacgagg 101640

aaaataccta ataaaaaaaa agaaaatatc taataaaaaa aaagagtaac cctcccttca 101700

aaaaactcag gaagacaaaa ccactaattt tctttctgaa gaaaacaaat cttcaaaacc 101760

ttagacaaac agtgcacacc tacactctct acctgctgaa aagcaagaac ttcactagag 101820

cctgggaaga gagcctgatc ctgcatgtac ttccaaattc tctgccatcc ctcccaagaa 101880

aatcattagt cctgggacca gcactaatag gcttttgaaa cttcataaca gtttatcaaa 101940

ctttggagac atgtttccac tggcattaag acgtgtttta ctgctgggca gtggtggcac 102000

atgcctttaa tcccagctct cgggaggcag aggcaggcgg atttctgaat ttgaggccag 102060

cctggtctac agagtgagtt ccaggacagc cagggctata cagagaaacc ctatctcgga 102120

aaaacaacaa caacaaaaaa gatgtgtttt actgtatgaa gccaggttct tcccactatg 102180

gaatgcctgg atctaacttg gcacactgcg taagcaatgc attttgagaa gcacaggaat 102240

caatgtgaca gacattagag gccaacttgt ctatctgtga agactaattg gcatcgctcc 102300

tggagataca gacagaggtt ccgcttctgt tgaatgacaa gtggtggcag tagtgatatc 102360

ctccaggaag cacgaagtcc tgctgaacac tgacaagcta gcagcaaatg ctgtctgtgc 102420

ttgctcagct agaacaccac cttcagcttc tttgccaatc tttgccaatc aaagattaaa 102480

gaaatagtat ggactcagga ggcagaggca ggtggatctc tgagtttgag tccagtctgg 102540

tctacagaga atttaaggac aacacagaga aaccctgtct tgaggagaaa aaaagcaaag 102600

aaaccaaaaa gtaatgtgta tttgcccttt gcaaaagcat cagtggaaaa tggaaaactt 102660

tagttttaaa agttctgaag gtaggtgtgg taatcgtgta cctcagcagt tgtctgagag 102720

aagacagtta tatcgtgagg gttatatgtt gagagacacc tacagctagg tagcaccagc 102780

cagaactaca tagtaaaaca ttgtttcaaa caaaagtttc tatacaattt ctgaaggatt 102840

ttcaaagttc ttacacacac acacacacac acacacacac attcttcttt cactgttgga 102900

ctcattctag acttggtggg ttcttacaat ttcctctgat attagagaat tctctaaaaa 102960

acaaattgaa agtaagtagt ggtaacaccc ctgtgttcat agcactcagg gggctgagac 103020

aaccggcgtg taagttaaag cccaacctgg ccttcttaac cagaccctat ctttaatggg 103080

ctgagagtgg gtctaaaatt tgaggttatt gaaaaatgtc tgaacactaa aactatttgc 103140

atagcatttt gagtttgata cttgccccag aataggcaaa ggcatataaa tacaagaagg 103200

gtaaaaacct tgacaaaact ttcccactga aaatgacttg ggatgggggt tgccaaagat 103260

gtacaacata tttatagttt tacttctcca gtaagggaac aactaataaa gtagcagttg 103320

ctacaaaaag aactaattct aggtctggga aggtggttca ttgattaaga gccctgattg 103380

ctcttcctga ggacctaagt tcaacttcca gctcacaacc atcggtaact ggcgttccag 103440

ggatccaatg ccttctggcc tttgtatgta ctgggacatg gatggtgcaa agacacacat 103500

gcagacaaaa gaacacatac atataaaata aaaaaaaatt taaatacaaa taattctgtt 103560

aggtttgttg aatgtccact tttcttcata atcaacgtat aacttataac atgtccattt 103620

atatgtccca tgtatctttc tctgcctgtg ccccatctaa gctatgatag aacatgagga 103680

atgagggaaa aggaaaggga ggagaaatag aaggaagaaa tttccaacac tctcgtcctt 103740

tctcttcccc actttcattt tattattttg tttccctttt tcatctccct gtccctttaa 103800

ggtgatgtcg attgtatctc aggcaggcct caaagttgat ttgtagccaa agatgccctt 103860

ggatttctga tccccctgct tccaatttcc agatgttaag attatgggct tgtgacatct 103920

catccctaga aaagcataag cttgtagaag tcaagggaca cttttattta ctgctgcctc 103980

tctagaaact tcctgccagt ttggcactta caaaatattt tttagaaaga agaggaaagt 104040

agataatcta tatactaaat aagtacttga taactgagtg gaacttaaaa ttaaaaaaaa 104100

aaagcagtgt ttgtgaacag gtttcagtac ctccccattt ttctcaaagc aaatggtcct 104160

ggcggctgtg tctcacacgt gggtaatgaa atctccctgc ctaaagatgt acaatgtgaa 104220

agtctgtttc cccttgtgat agaggttaac attgtaagcc ctgcagcacc acatggctca 104280

ggtagtgttg tggttaaaat tgtgtttggc caaaagaaac tccaacacat atatgccatc 104340

gctacttcta ttttttttct taaacataat aaaatttaaa gaaagaaaaa cctcacaatt 104400

gttaggattt agtggcagaa ggtccttgat gggttggggc agagatgtgc tgcaaagaga 104460

tcacaccatg caaacagatc tcaggagaga ggccatctca gagtggggac ataaaagaga 104520

gagttagagt cagagagcca gactgaaaga gacagactga gagactggaa gacaaagaga 104580

atgggggtgt gttggggggg gggttggtaa gggttttgta acttgtggaa acagtgtaaa 104640

gagtggcatt tggggaaggg aggtgatgat gtgccttttg gcgctgagtt cctgagggca 104700

ggcttgacaa gtgcctgctt tctaacatta atggccattg atactggaaa aaaaaactat 104760

tttattacta cattaattga aatttgcaac tatatttata aataatattt atacatttat 104820

ggagtcatgt taactttcag cccaaggaga gataacatta aaaatgaaat atattttata 104880

aagaaaatat tttcttaacc tcgtaaaagt atacacagta aactatggtt atctgtaaca 104940

tttaaagtaa ataattttag cttacaattt aattatgatg ctgatggggt atgttcagaa 105000

agttattcat gaaaagttcc aattccttac acatagattt tccaactact ttcttttgtt 105060

tattcagaaa ggatgggaaa ctacgagggc taacacccta cctccttgtt taagggactg 105120

actcaatctt ctactggaga tgccccattg cttttgactt actatgttca ttcagccttc 105180

tattttaggt ttgattagtt tgattctaca cttaactttc tcctgacata aagctctcaa 105240

taagaaagta tattcattaa cattggcctc agaaagagag aggttttagg ctgttcactg 105300

gatatatgat cagaataaaa gagatacaat acatacacat cagagagagc tgctgtgttg 105360

gtgccagaaa ttgaatccag gtcctctgaa agaagagcca gtgctcttaa gcacctagta 105420

ctgtcttcag ctccaacaag taggtttaaa tcttattttg caatgggacc tggtggctca 105480

tgcctttaat cctaggtgaa tgactgtgat cttgaaggta gcttggtcta cataatgaat 105540

tccaggacag ccagggttat gtaaaaaaaa aaaaaaatgt gtcaaaacaa aacaaaaaaa 105600

aaccttattt tgggagggaa aaattggggt ttctgtcctg acaaatccct agcctttctg 105660

ttgaattctt tataaaaaat gtatttgtgt aaaagctctt ttgttccttt tgcacccaac 105720

tctcctgcat gaaaggtcaa catgaaaata ttaaaaatca caaccaagat cggatgaaat 105780

ttaaattata attactaaat gggcacatcc aaattattat gacagagaaa acaaaagccc 105840

taggactagg gagatgtgga aaaatgaagc agtcatgaaa tactaaaacc attcttaact 105900

gtccttattc tggaagggga aaatcaacat ttccctgaaa gctgctgtaa tcatgtgaag 105960

ttcaaatggt ttgatgagcc ttcctccaat caaacagata tgatagcaac taaatttctc 106020

caactaaatt atttacaact gactgagaca gtccctctga agccaggtac tcagctaaac 106080

tattcagaat gaaataggaa cggagaagag ggtggaaggc tctgtaatga cagaccacac 106140

tggaatagta gcccactacc tgacttcgta gatgtcctga tatgatggga atgatagaca 106200

agcatgacag taaggttatg aggtgggaag aagtgagtgg aattacacaa aatctataaa 106260

gaggaagtga agcaaatgat gtagcaagcc accctcatag gattttgcat ctgatgattg 106320

agatggttac taggatctct agctatgaaa tctaaaacag cttttttggg gggggggaat 106380

caattacctg tagttttatt tcttgttcat ttttctttct ttgaatagca tgtttgtcct 106440

gagccatgaa agtctcccac atacaaacca aaagaaggaa aaacaaacat tcgataatcc 106500

agttcactga aggaaagtac agtggtttaa atatgcttac cccagggagt ggcactatta 106560

gaaggtgtgc cttgtagaag gaggtgtggc cttgttggag ggagcgtgtt actgtgggtg 106620

tgggctttga gaccctcctt ctagccatgt ggaagacagt cttctctttg ccttcaaaac 106680

aagatgtaca actcagcttt cccggcacca tgtcatgctt cccactgtga tgataatagc 106740

ctgaacctca gaacctgcaa gtcagcctca attaaacgtt gtcctttata aaagttgcct 106800

tggtcatggt ttttcttcac agcaatgaaa accctaagaa agaagtgata atgaaattta 106860

taaagagaaa taatatgtat tttatgaggt atcacatgct gtaatattca gtagcacatg 106920

aggattgaaa attcactaaa attcagtggc tacttctggt ggttctacct ggaatgcttt 106980

tatttttaaa agaacatcaa ctcagtgcaa agtggtttcc attgttttta tgtaactttt 107040

ctagatatga acctctgttt cggctttcct gtctcaccaa tttgtctcta gacacccatt 107100

ctactaagaa attccacaga gtgtcttata catatactgt tttatacaag gtctctattc 107160

ctctattcca tacaccccat aacttgtttc tctcctattt ccttacaaat gaaggataaa 107220

gttaaagcaa tttttggaaa agaattttat tctcacatga aagcacaggt tgcggcctat 107280

gtgggtgctg cctcccttcc tcttcctcct ccccactcct ctctggttgc catggagaat 107340

acagttgatg gaaacataca attacaagca acgata 107376

<210> 8

<211> 708

<212> PRT

<213> 人工序列

<220>

<223> SV40大T抗原GenBank：AAB59924.1的合成氨基酸序列

<400> 8

Met Asp Lys Val Leu Asn Arg Glu Glu Ser Leu Gln Leu Met Asp Leu

1 5 10 15

Leu Gly Leu Glu Arg Ser Ala Trp Gly Asn Ile Pro Leu Met Arg Lys

20 25 30

Ala Tyr Leu Lys Lys Cys Lys Glu Phe His Pro Asp Lys Gly Gly Asp

35 40 45

Glu Glu Lys Met Lys Lys Met Asn Thr Leu Tyr Lys Lys Met Glu Asp

50 55 60

Gly Val Lys Tyr Ala His Gln Pro Asp Phe Gly Gly Phe Trp Asp Ala

65 70 75 80

Thr Glu Ile Pro Thr Tyr Gly Thr Asp Glu Trp Glu Gln Trp Trp Asn

85 90 95

Ala Phe Asn Glu Glu Asn Leu Phe Cys Ser Glu Glu Met Pro Ser Ser

100 105 110

Asp Asp Glu Ala Thr Ala Asp Ser Gln His Ser Thr Pro Pro Lys Lys

115 120 125

Lys Arg Lys Val Glu Asp Pro Lys Asp Phe Pro Ser Glu Leu Leu Ser

130 135 140

Phe Leu Ser His Ala Val Phe Ser Asn Arg Thr Leu Ala Cys Phe Ala

145 150 155 160

Ile Tyr Thr Thr Lys Glu Lys Ala Ala Leu Leu Tyr Lys Lys Ile Met

165 170 175

Glu Lys Tyr Ser Val Thr Phe Ile Ser Arg His Asn Ser Tyr Asn His

180 185 190

Asn Ile Leu Phe Phe Leu Thr Pro His Arg His Arg Val Ser Ala Ile

195 200 205

Asn Asn Tyr Ala Gln Lys Leu Cys Thr Phe Ser Phe Leu Ile Cys Lys

210 215 220

Gly Val Asn Lys Glu Tyr Leu Met Tyr Ser Ala Leu Thr Arg Asp Pro

225 230 235 240

Phe Ser Val Ile Glu Glu Ser Leu Pro Gly Gly Leu Lys Glu His Asp

245 250 255

Phe Asn Pro Glu Glu Ala Glu Glu Thr Lys Gln Val Ser Trp Lys Leu

260 265 270

Val Thr Glu Tyr Ala Met Glu Thr Lys Cys Asp Asp Val Leu Leu Leu

275 280 285

Leu Gly Met Tyr Leu Glu Phe Gln Tyr Ser Phe Glu Met Cys Leu Lys

290 295 300

Cys Ile Lys Lys Glu Gln Pro Ser His Tyr Lys Tyr His Glu Lys His

305 310 315 320

Tyr Ala Asn Ala Ala Ile Phe Ala Asp Ser Lys Asn Gln Lys Thr Ile

325 330 335

Cys Gln Gln Ala Val Asp Thr Val Leu Ala Lys Lys Arg Val Asp Ser

340 345 350

Leu Gln Leu Thr Arg Glu Gln Met Leu Thr Asn Arg Phe Asn Asp Leu

355 360 365

Leu Asp Arg Met Asp Ile Met Phe Gly Ser Thr Gly Ser Ala Asp Ile

370 375 380

Glu Glu Trp Met Ala Gly Val Ala Trp Leu His Cys Leu Leu Pro Lys

385 390 395 400

Met Asp Ser Val Val Tyr Asp Phe Leu Lys Cys Met Val Tyr Asn Ile

405 410 415

Pro Lys Lys Arg Tyr Trp Leu Phe Lys Gly Pro Ile Asp Ser Gly Lys

420 425 430

Thr Thr Leu Ala Ala Ala Leu Leu Glu Leu Cys Gly Gly Lys Ala Leu

435 440 445

Asn Val Asn Leu Pro Leu Asp Arg Leu Asn Phe Glu Leu Gly Val Ala

450 455 460

Ile Asp Gln Phe Leu Val Val Phe Glu Asp Val Lys Gly Thr Gly Gly

465 470 475 480

Glu Ser Arg Asp Leu Pro Ser Gly Gln Gly Ile Asn Asn Leu Asp Asn

485 490 495

Leu Arg Asp Tyr Leu Asp Gly Ser Val Lys Val Asn Leu Glu Lys Lys

500 505 510

His Leu Asn Lys Arg Thr Gln Ile Phe Pro Pro Gly Ile Val Thr Met

515 520 525

Asn Glu Tyr Ser Val Pro Lys Thr Leu Gln Ala Arg Phe Val Lys Gln

530 535 540

Ile Asp Phe Arg Pro Lys Asp Tyr Leu Lys His Cys Leu Glu Arg Ser

545 550 555 560

Glu Phe Leu Leu Glu Lys Arg Ile Ile Gln Ser Gly Ile Ala Leu Leu

565 570 575

Leu Met Leu Ile Trp Tyr Arg Pro Val Ala Glu Phe Ala Gln Ser Ile

580 585 590

Gln Ser Arg Ile Val Glu Trp Lys Glu Arg Leu Asp Lys Glu Phe Ser

595 600 605

Leu Ser Val Tyr Gln Lys Met Lys Phe Asn Val Ala Met Gly Ile Gly

610 615 620

Val Leu Asp Trp Leu Arg Asn Ser Asp Asp Asp Asp Glu Asp Ser Gln

625 630 635 640

Glu Asn Ala Asp Lys Asn Glu Asp Gly Gly Glu Lys Asn Met Glu Asp

645 650 655

Ser Gly His Glu Thr Gly Ile Asp Ser Gln Ser Gln Gly Ser Phe Gln

660 665 670

Ala Pro Gln Ser Ser Gln Ser Val His Asp His Asn Gln Pro Tyr His

675 680 685

Ile Cys Arg Gly Phe Thr Cys Phe Lys Lys Pro Pro Thr Pro Pro Pro

690 695 700

Glu Pro Glu Thr

705

<210> 9

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> SV40小t抗原GenBank：AAB59925.1的合成氨基酸序列

<400> 9

Met Asp Lys Val Leu Asn Arg Glu Glu Ser Leu Gln Leu Met Asp Leu

1 5 10 15

Leu Gly Leu Glu Arg Ser Ala Trp Gly Asn Ile Pro Leu Met Arg Lys

20 25 30

Ala Tyr Leu Lys Lys Cys Lys Glu Phe His Pro Asp Lys Gly Gly Asp

35 40 45

Glu Glu Lys Met Lys Lys Met Asn Thr Leu Tyr Lys Lys Met Glu Asp

50 55 60

Gly Val Lys Tyr Ala His Gln Pro Asp Phe Gly Gly Phe Trp Asp Ala

65 70 75 80

Thr Glu Val Phe Ala Ser Ser Leu Asn Pro Gly Val Asp Ala Met Tyr

85 90 95

Cys Lys Gln Trp Pro Glu Cys Ala Lys Lys Met Ser Ala Asn Cys Ile

100 105 110

Cys Leu Leu Cys Leu Leu Arg Met Lys His Glu Asn Arg Lys Leu Tyr

115 120 125

Arg Lys Asp Pro Leu Val Trp Val Asp Cys Tyr Cys Phe Asp Cys Phe

130 135 140

Arg Met Trp Phe Gly Leu Asp Leu Cys Glu Gly Thr Leu Leu Leu Trp

145 150 155 160

Cys Asp Ile Ile Gly Gln Thr Thr Tyr Arg Asp Leu Lys Leu

165 170

<210> 10

<211> 22

<212> PRT

<213> 人工序列

<220>

<223> 肽F2A的合成氨基酸序列

<400> 10

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val

1 5 10 15

Glu Ser Asn Pro Gly Pro

20

<210> 11

<211> 20

<212> PRT

<213> 人工序列

<220>

<223> 肽E2A的合成氨基酸序列

<400> 11

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser

1 5 10 15

Asn Pro Gly Pro

20

<210> 12

<211> 19

<212> PRT

<213> 人工序列

<220>

<223> 肽P2A的合成氨基酸序列

<400> 12

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn

1 5 10 15

Pro Gly Pro

<210> 13

<211> 18

<212> PRT

<213> 人工序列

<220>

<223> 肽T2A的合成氨基酸序列

<400> 13

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro

1 5 10 15

Gly Pro

<210> 14

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成肽 (LXCXE基序)

<220>

<221> MISC_FEATURE

<222> (2)..(2)

<223> X是任何氨基酸

<220>

<221> MISC_FEATURE

<222> (4)..(4)

<223> X是任何氨基酸

<400> 14

Leu Xaa Cys Xaa Glu

1 5

<210> 15

<211> 166040

<212> DNA

<213> 人工序列

<220>

<223> 合成多核苷酸

<400> 15

tcaacatcct taatcatcag gaaaatgcaa atcaaaacaa ccctgagatt ccacctcaca 60

ccagtcagaa tggctaagat caaaaattca ggtgacagca gatgctgccg aggatgtgga 120

gaaagaggaa cactcctcca ttgttggtgg gattgcaagc ttgtacaacc actctggaaa 180

tcagtctggc agttcctcag aaaattggac atagtactac tggaggatcc cgcaatacct 240

cttctgggca tatatccaga agatgtttca accagtaaga aaaacacatg ctccactatg 300

ttcatagcag ccttatttat aatagccaga agctggaaag tatccagatg cccctcaaca 360

gaggaatgga tacagaaaat gtgatacatt tacacaatgg agtactactc agctacgaaa 420

aagaatgaat ttatgaaatt cctaggcaaa tggatggacc tggagggcat catcctgagt 480

gaggtaaccc aatcacaaaa gaactcacac aatatgtact ccctgataag tggatattag 540

cccagaaact tagaataccc aagatataag atacaatttg ctaaacgcat gaaactcaag 600

aagaacaaag accaaagtgt ggacactttg ccccgtctta gaattgggaa caaaacaccc 660

atggaaggag ttacagagac aaaggttgga gctgagacaa aaggatgggc catctagaga 720

ctaacatatc aggggatcca tcccataatc agcttccaaa tgctgacacc actgtgtaca 780

ctagcaagat tttgctgaaa ggacccagat atggctgtct cttctgagac tatgctgggg 840

cctagcaaac acagaagtgg atgctcacag tcagctattg gatggatgac agagctccca 900

atagaggagc tagagaaagt acccaagtag atgaagggat ctgcaatcct ataggtggat 960

caaaaatatg aactaagcaa tacccctctg gagctcgtgt ctctagctgc atatgaatca 1020

gaaaatggcc tagtcggcaa tcaatggaaa gagaggccca ttggttgtcc aaactttata 1080

tgcctcaata caggggaacg ccagggccaa gaagtgggag tgggtgggta ggtgagtgct 1140

tctggaagcc tgttggggac tttctggata acattggaaa tgtaaatgaa ataaataccc 1200

aataataaaa aaagaacatt caaaaaaaaa aaaaaagatc ctaacccaaa acatccatga 1260

tatccaggac ataatgagaa agcaaggtta ttccattata aaaacatttt tttttttagt 1320

atagaataga gtttatatag ggtataggta ggggagttaa gagagtagta gagacagaga 1380

aaggcagaga gaagaagaga atagagaagt agaggccggt catgaccaca tggaaagagg 1440

gggaagggaa tgcagagaaa ggggacacat ggggcaggag agaggcaaga gtgtaagagt 1500

acaaaaccaa atttacacaa tgtttttcca taaatttagc cctacaaagg ataataggtg 1560

gaaaacacca caacaaggag ggaaactaca ccctcaaaaa agcaagaaag taatcttaca 1620

tcaaacccaa aagaaaatag ctacatgaac agaatttcaa ctctaataac aaaaataaca 1680

ggaagcaaaa atggctttta cttaaaatct cttaacatcc acggactcaa ctctccaata 1740

aaaacacata tattaataga ctggatatgt aaacaggacc cagcattttg ctgcatacag 1800

gaaacgcgcc tcagtgacaa agacagatac tacctcagag taaaaggcta gaaaacaatt 1860

ttccaagcaa gtggtcccaa gaaacaagct gtaataacca ttctaatatc aaataaaatt 1920

aacttaatag aaacagattt gtaaaagtgg attaaggaac tccacataaa accagagaca 1980

ctgaaactta tagaggagaa agtagggaaa agcctcgaag atatgggtac aggggaaaaa 2040

ttcctgaata gaacagcaat ggcttgtgct gtaagatcga gagtcaacga atgggacctc 2100

ataaaattgc aaagcttctg caaggaaaaa gacaccatca gtaagacaaa aaggctacca 2160

acagagtggg aaaggatctt tacctattct aaatcagata ggggactaat atccaatata 2220

tataaagaac tcaagaaggt ggactccaga aaattaaata agcccattaa aaatggggct 2280

cagagataaa caaagaattc tcacctgagg aataccgaat ggctgagaag cacttgaaaa 2340

aatgttcaac atccttaatc atcaggaaaa tgcaaatcaa aacaaccctg agattccacc 2400

tcacaccagt cagaatggct aagatcaaaa attcaggtga cagcagatgc tgccgaggat 2460

gtggagaaag aggaacactc ctccattgtt ggtgggattg caagcttgta caaccactct 2520

ggaaatcagt ctggcagttc ctcagaaaat tggacatagt actactggag gatcccgcaa 2580

tacctctcct gggcatatat ccagaagatg tttcaaccag taagaaaaat acatgctcca 2640

ctatgttcat agcagcctta tttataatag ccagaagctg gaaagtatcc agatggccct 2700

caacagagga atggatacag aaaatgtgat acatttacac aatggagtac tactcagcta 2760

ttaaaaagaa tgaatttatg aaattcctag ccaaatggat ggacgtggag ggcatcatcc 2820

tgagtgaggt aacccaatca caaaagaact cacacagtat gtactcactg ataagtggat 2880

attagctcag aaacttagaa tacccaagat ataggataca atttccaaaa cacatgaaac 2940

tcaagaagac caaagaccaa aatatggaca ttttgccctg tcttagaatt gggaacaaaa 3000

cacccatgga aggagctaca gagacaaagt ttggagctga gacgaaaggt tggaccctct 3060

agagactgcc atatccgggg atccatccca taatcagctt ccaatcgctg acaccattgc 3120

atacactagc aagatcttgc tgaaaggacc cagatatagc tgtctcttgt gagactatgc 3180

tggggcctag caaacacaga agtggatgct cacagtcagc tattggatgg atcacagggc 3240

ccccaatgga ggacctagag aaagtaacca aggagctaaa gggatttgca accctataag 3300

tggaacaaca atatgaacta agcattaccc cccagagctc gtgtctctag ctgcatatgt 3360

ataagaagat ggcctagtcg gccatcagtg gaaagagagg cccattggtc gtgcaaactt 3420

tatatgcctc agtacagggg aacagcaggg ccaagaagtc atagtgagag ggttggggag 3480

tgggtggggg agcgtgtggg ggacttttgg gatagcattg gaaatgtaac tgaaataaat 3540

acctaattaa aaaattagaa aatcaaaaaa agaaggtctt tttttttcac aatattaatt 3600

ctactaggct gtacacttac gagatcttca aattctagta tgtttctttt ttctttcttt 3660

tttttaaaga tatatttatt tattttatgt atgtgagtac actgtagctg tcttcagatg 3720

caccagaaga gcgcatcaga tctcattaca gatggtcatg agccaccatg tggttgctgg 3780

gaattgaact caggacctct ggaagagcag ttggttctct taaccgctga gccatctctc 3840

cagcccctct agtatgtttc ttaatctctt tctttacaca tttaaagttt tcattgtaga 3900

gggtttttta accacttttg ttatgtatat tctaaatatt ttattttatt tgagaaactg 3960

gtaagaggag tgtgtccatg atctctttct cagaatgctt gttactcata tgtattaaga 4020

cttatgaatt tgacaagtcc cttccgcttg actcgagccc cgggctacct tgccagcaga 4080

gtcttgccca acacccgcaa gggcccacac gggactcccc acgggatcct aagacctctg 4140

gtgagtggaa cacagcgcct gccccaatcc aatcgcgcgg aacctgagac tgcagtacat 4200

agggaagcag gctacccggg cctgatctgg ggcacaagcc ccttcagctc cactcgagcc 4260

ccgggctacc ttgccagcag agtcttgccc aacacccgca agggcccaca cgggactccc 4320

cacgggatcc taagacctct ggtgagtgga acacaacttc tgccaggagt ctggttcgaa 4380

caccagatat ctgggtacct gccctgcaag aagagagctt gcctgcagag aatactctgc 4440

ccactgaaac taagaagagt gctaccctcc aggtctgctt atagaggcta acagagtcac 4500

ctgaagtaca agctcttaac agagacaact ataacagcta gcttcagaga ttaccagatg 4560

gcgaaaggca aacgtaagaa tcctactaac agaaatcaag accactcacc aacatcagaa 4620

cgcagcactc ccaccccacc tagtcctggg caccccaaca caaccgaaaa tctagaccca 4680

gatttaaaaa catttctcat gatgatgata gaggacatca agaaggactt tcataagtca 4740

cttaaagaat tacaggagag cactgctaaa gagttacagg cccttaaaga aaagcaggaa 4800

aacacagcca aacaggtaga aatcattaaa gaaaaacagg aaaacacatc caaacaggtg 4860

atggaaatga acaaaaccat actagaacta aaagggtaag tagacacaat aaagaaaacc 4920

caaagcgagg caacgctaga gatagaaacc ctaggaaaga gatctggaac catagatgtg 4980

agcatcagca acagaataca agaaatggaa gagagaatct caggagcaga agattccata 5040

gagaacatcg acacaacagt caaagaaaat acaaaatgca aaaggatcct aactcaaaac 5100

atccaggtaa tccaggacac aatgagaaga ccaaacctac ggataatagg aataaatgag 5160

aatgaagatt ttcaacttaa agggccagct aatatcttca acaaaataat agaagaaaat 5220

ttcccaaaca taaaaaaaga catgcccatg atcatacaag aagcctacag aactccaaat 5280

agactggacc agaaaagaaa ttcctcccga cacataataa ttagaacaac aaatgcaata 5340

aataaagata gaatattaaa agcagtaagg gagaaaggtc aagtaacata taaaggaagg 5400

actatcagaa ttacaccaga cttttcacca gagactatga aagccagaag agcctggaca 5460

gatgttatac agacactaag agaacacaaa tgccagccca ggctactata cccggccaaa 5520

ctctcaatta ccatagatgg agaaaccaaa gtattccacg acaaaaacaa attcacacaa 5580

tatctttcca tgaatccagc ccttcaaagg ataataacag aaaagaagca atacaaggac 5640

ggaaatcacg ccctagaaca accaagaaag taatcattca acaaaccaaa aagaagacag 5700

ccacaagaac agaatgccaa ctctaacaac aaaaataaaa ggaagcaaca attacttttc 5760

cttaatatct cttaatatca atggactcaa ttccccaata aaaagacata gactaacaga 5820

ctggctacac aaacaggacc caacattctg ctgcttacag gaaacccatc tcagggaaaa 5880

agacagacac tacctcagag tgaaaggctg gaaaacaatt ttccaagcaa atggactgaa 5940

gaaacaagct ggagtagcca ttttaatatc ggataaaatc gacttccaac ccaaagttat 6000

caaaaaagac agggagggac acttcatact catcaaaggt aaaatcctcc aagaggaact 6060

ctcaattctg aatatctacg caccaaatgc aagggcagcc acattcatta gagacacttt 6120

agtaaaactc aaacatacat tgcacctcac acaataatag tgggagactt caacacacca 6180

ctttcttcaa aggacagatc gtggaaacag aaactaaaca gggacacagt gaaactaaca 6240

gaagttatga aacaaatgga cctgacagat atctacagaa cattttatcc taaaacaaaa 6300

ggatatacct tcttctcagc acctcacggg accttctcca aaattgatca tataattggt 6360

cacaaaacag gcctcaatag atacaaaaat attgaaattg tcccatgtat cctatcagac 6420

caccatggcc taagactgat cttcaataac aacataaata atggaaagcc aacattcacg 6480

tggaaactga acaacactct tctcaatgat accttggtca aggaaggaaa aaagaaagaa 6540

attaaagact ttttagagtt taatgaaaat gaagccacaa cgtacccaaa cctttgggac 6600

acaatgaaag catttctaag agggaaactc atagctctga gtgcctccaa gaagaaacgg 6660

gggacagcac atactagcag cttgacaaca catctaaaag ccctagaaaa aaaggaagca 6720

aattcaccca agaggagtag acggcaggaa ataatcaaac tcaggggtga aatcaaccaa 6780

gtggaaacaa gaagaaatat tcaaagaatt aaccaaacga ggagttggtt ctttgagaaa 6840

atcaacaaga tagataaacc cttagctaga ctcactaaag ggcacaggga caaaatccta 6900

attaacaaaa tcagaaatga aaagggagac ataacaacag atcctgaaga aatccaaaac 6960

accatcagat ccttctacaa aaggctatac tcaacaaaac tggaaaacct ggacgaaatg 7020

gacaaatttc tggacagata ccaggtacca aagttgaatc aggatcaagt tgatcatcta 7080

aacagtccca tatcacctaa agaaatagaa gcagttatta atagtctccc aaccaaaaaa 7140

agcccaggac cagatgggtt tagtgcagag ttctatcaga ccttcaaaga agatctaatt 7200

ccagttctgc acaaactatt tcacaaaata gaagtagaag gtactctacc caactcattt 7260

tatgaagcca ctattactct aatacctaaa ccacagaaag acccaacaaa gagagaactt 7320

cagaccaatt tctcttatga atatcgatgc aaaaatcctc aataaaattc tcgctaacca 7380

aatccaagaa cacattaaag caatcatcca tcctgaccaa gtaggtttta ttccagggat 7440

gcagggatgg tttaatatac gaaaatccat caatgtaatc cattatataa acaaactcaa 7500

agacaaaaac cacatgatca tctcgttaga tgcagaaaac gcatttgaca agatccaaca 7560

cccattcatg ataaaagttt tggaaagatc aggaattcaa ggcccatacc taaacatgat 7620

aaaagcaatc tacagcaaac cagtagccaa catcaaagta aatggagaga agctggaagc 7680

aatcccacta aaatcaggga ctagacaagg ctgcccactt tctccctacc tgcccacttt 7740

ctccctacct tttcaacata gtacttgaag tattagccag agcaattcga caacaaaagg 7800

agatcaaggg gatacaaatt ggaaaagagg aagtcaaaat atcacttttt gcagatgata 7860

tgatagtata tataagtgac cctaaaaatt ctaccagaga acacctaaac ctgataaaca 7920

gcttcggtga agtagctgga tataaaatta actcaaacaa gtcaatggcc tttctctaca 7980

caaagaataa acaggctgag aaagaaatta gggaaacaac acccttctca atagtcacaa 8040

ataatataaa atatcttggc gtgactctaa ctaaggaagt gaaagatctg tatgataaaa 8100

acttcaaatc tctgaagaaa gaaattaagg aagatctcag aagatggaaa gatctcccat 8160

gctcatggat tggcaggatc aacattgtaa aaatggctat cttgccaaaa gcaatctaca 8220

gattcaatgc aatccccatc aaaattccaa ctcaattctc aaacgaattg gaaggagcaa 8280

tttgcaaatt tgtctggaat aacaaaaaac ctaggatagc aaaaagtctt ctcaaggata 8340

aaagaacttc tggcggaatc accatgccag acctaacgct ttactgcaga gcaattgtga 8400

taaaaactgc atggtactgg tatagagaca gacaagtaga ccaatggaat agaattgaag 8460

acccagaaat gaacccacac acctatggtc acttgatctt cgacaaggga gctaaaacca 8520

tccagtggaa gaaagacagc tttttcaaca attagtgctg gcacaactgg ttgatatcgt 8580

gtagaagaat gcgaatcgat ccatacttat ctccttgtac taaggtcaaa tctaagtgga 8640

ttaaggaact tcacataaaa ccagagacac tgaaacttat agaggagaaa gtggggaaaa 8700

gccttgaaga tatgggcaca ggggaaaaat tcctgaacag aacagcaatg gcttgtgctg 8760

taagatcaag aattgacaca tgggacctaa tgaaactcca aagtttctgc aaggcaaaag 8820

acaccgtcaa taagacaaaa agaccaccaa cagattggga aaggatcttt acctatccta 8880

aatcagatag gggactaata tccaacatat ataaagaact caagaaggtg gacttcagaa 8940

aatcaaataa ccccattaaa aaatggggct cagaactgaa caaagaattc tcacctgagg 9000

aataccgaat ggcagagaag cacctgaaaa aatgttcaac atccttaatc atcagggaaa 9060

tgcaaatcaa aacaaccctg agattccacc tcacaccagt cagaatggct aagatcaaaa 9120

atttaggtga aagcagatgt tggcgtggat gtggagaaag aggaacactc ctccattgtt 9180

ggtgggagtg caggcttgta caaccactct ggaaatcagt ctggcggttc ctcagaaaat 9240

tggacatagt actaccggag gatccagcaa tacctctcct gggcatatat ccagaagaag 9300

ccccaactgg taagaaggac acatgctcca ctatgttcat agcagcctta tttataatag 9360

ccagaaactg gaaagaaccc agatgcccct caacagagga atggatacag aaaatgtggt 9420

acatctacac aatggagtac tactcagcta ttaaaaagaa tgaatttatg aaattcctag 9480

ccaaatggat ggacctggag ggcatcatcc tgagtgaggt aacacattca caaagaaact 9540

cacacaatat gtactcactg ataagtggat actagcccca aacctaggat acccaagata 9600

taagatataa tttgctaaac acataaaact caagaagaat gaagactgaa gtgtggacac 9660

tctgcccctc cttagatttg ggaacaaaac acccatggaa ggagttacag agacaaagtt 9720

tggagctgag atgaaaggat ggaccatgta gagactgcca tatccaggga tccaccccat 9780

aatcagcatc caaacgctga caccattgca tacactagca agattttatc gaaaggaccc 9840

agatgtagct gtctcttgtg agactatgcc ggggcctagc aaacacagaa gtggatgctc 9900

acagtcagct aatggatgga tcatagggct cccaatggag gagctagaga aagtagccaa 9960

ggagctaaag ggatctgcaa ccctataggt ggaacaacat tatgaactaa ccagtacccc 10020

ggagctcttg actctagctg catatatatc aaaagatggc ctagtcggcc atcactggaa 10080

agagaggccc attggacttg caaactttat atgccccagt acaggggaac accagggcca 10140

aaaaggggga gtgggtgggt aggggagtgg gggtgggtgg atatggggga cttttggtat 10200

agcattggaa atgtaaatga gctaaatacc taataaaaaa tgggaaaaaa agacttatga 10260

attttataag tcaattatgt atcacaatag ttctctgaaa ttattgataa tttctataat 10320

ttttctagtc aaattttggg aacattgggt aaaaggtaat atgatcttca attgaaaata 10380

attttactta ttatttttct atttgtatcc cttctcttgc cttattgctc cagctaatgc 10440

ttcaatcaca ttatggataa gcagtaggga tagtgagcat tcctttccca ttttgatttt 10500

aatggtgctt attaatgttt tttattaatt taggaagata ttggccatag ttttgacata 10560

cataaccttt attatgttgg aatatatttc ctacagtcct acttgttctt tggcttttat 10620

taaaaagaca tgttgaggcc atcatgggcg cgaactcagt gggccctagc acacccagga 10680

tcttggaatc actggtgagt ggaacgcaac atctgttcca aaaaacccag agggtcttgt 10740

gccagcagga acaaggacaa aggaaacctg ctcaaccagc tgctggggtt tgttcccatt 10800

ggcgccagcc ccatctgatc ttggacgcat actcagcagg ccatagcaca cccagtatct 10860

tgggattact aacaccagtc tgctcaggag agcacataag cagcagaagc aacagagctt 10920

cttggacagg gtcccttcgg gccttcatcc tcagccagga ggcagagctg agacccagac 10980

ccctgggtac cttccccatc agaggagagt tggcctacgg ggagtactct gacctcagaa 11040

ttcaggaggt gaatctgggc tgcagaattc tgtgcacctt tcctgcaaga ggaaagcttg 11100

cctgcagaga gtgctctgac cactgggatt caggaaagtt agtctctcag gagtgctgac 11160

agaggctaaa gaatcacagg aggaacaagc tccagacaga gatagctaca acatctaaca 11220

caagagatta ccagttggtg aaagaaaaac ctaagaatct taataacagg agccaagacc 11280

actcagcatc atcagaaccc agtacaccca ccacagtgtg ttttggatat cccaacacac 11340

ctgaaaagca agactctcat ttaaaatcat atctcatgat ggtggtagaa aattttaaga 11400

atggcattaa taactcactt aaagaaatat aggagaacac tgctaaacag gtaaaaaccc 11460

ttaaagagga aggacaaaaa cccctcaagg aattacagga gaacactgct aaacaggtag 11520

aagcccttaa agaggaaaca caaaaatccc tcaaggaatt acaggagaac atggctaaac 11580

aggtagaagt ccttaaagaa ctacaggcaa acactgctaa acaggtagaa gtccttaaag 11640

aagaaacaca aaaatccctt aaagaattac aggaaaacac aaccaaagag gggatggaat 11700

tgaacaaagc catccaagat ataaaaatgg aagtagaagc aatgaagaaa acccaaaggg 11760

aaacaactct ggagatagaa accctaggaa agaaatcagg aagcatagat gtgaacatca 11820

gcaacagaat acaagagatg gaagagagaa tctcaggtgc agaagattcc atacggaaga 11880

tggacacaac aatcaaagaa aatgcaaaat gcaaaaagat cttaactcaa aacatccagg 11940

aaatccagga caaaatgaga agaccacacc tatggataag aggagtagat gagaatgaag 12000

attttcaact taaagggcca gcaaatatct tcaacaaaat tatagaagaa aacttcccaa 12060

acctaaagaa tgacatgccc atgaacatac aagaagccta cagaactcca aatagactga 12120

accagaaaat aaattcctcc caacacataa taattagaac aacaaatgca ctaaataaag 12180

agagaatatt aaaagcagta agggaaaaag gacaagtaac atataattgc aggcctatta 12240

gaattactcc agacttctta caagagacta tgaaggctag aagatcctgg acagatgtta 12300

cacagacacc aagagaacac aaatgccagc caaggctaat ataaccagca aaactctcaa 12360

ttaccataca tagagaaaca aaggattcca tgacaaaacc aaattcacac aatacctttt 12420

cgtgaatcca gtccttcaaa ggataataaa gggaaaacac caaaacaatg atggaaatta 12480

tgccctagaa aaagcaagaa aataaccctt caacaaaact aaaagaagac agccacaaaa 12540

acagaatgcc aactctaaca acaaaaatga caggaagcaa caattacttt tccttaatat 12600

ctcttaatat caatggattc aattccccaa taaaaagaca tagactaaca gactggctac 12660

ataaacagga ccaacatttt gctgcttaca ggaaacccac ctcatggaaa aagacagaca 12720

ctacctcaga gtgaaaggct ggaaaacaat tttccaagca aatggtccaa agaaacaagc 12780

tggagtatcc attttaatat ctaaaaaaaa tcaacttcca acccaaagtt atcaaaaaag 12840

tcaaggaggg gcacttcata tgcattaaag gtaaaatctt ccaagatgaa ctctcaattt 12900

tgaatatcta tgctccaaat gcaagggcat ccacattcat taaacaatag tatagtaaag 12960

ctcaaaacac atattgcacc tcatacaata atattgggag acttcaacac ccaactgtca 13020

tcaatggaca gatcctggaa acagaatcta aacagagaca cattgaacct agcagaagtt 13080

aggaaacaaa aggatttaac agatatctac agaatatttt atcttaaaac aaaagtatat 13140

accttcttct cagcacctca tggtaccttc tccaaaactg accatataat tggtcacaaa 13200

acaggcctca acagatgtaa aactattgag attatcccat gcatcctatc agatcaccag 13260

ggactaaggc tgatcttcaa taaaaataat aataaatatt agaaagtcaa cattcacgtg 13320

gaagctgaac aacactctac tcaatgatat cttgatcagg gaagaaataa agaaagaaat 13380

taaagacttt ttagagttta atgaaaatga agccacaaca tacccaaact tatgtgacac 13440

aatgaaagca ttcgtaagag gaaaactcat agccctgagt gcctccaaaa agaaactaga 13500

gagaatcata cactaacagc ttgacaacac acctaaaagt tctagaacaa aaggaagcaa 13560

attcacccaa gaggagtaga cagcaagaaa taatcacact cagggttgaa atcaaccaag 13620

tggaaacaaa aagaactgtt cagagaatca accaaaccag gagctggttc tttgagaata 13680

tcaacaagat agataaaccc ttagccagac taactaacgg tcacagggac agtatcctaa 13740

tgaacaaaat cagaaatgaa aagtacccaa ggagctaaga ggttcggcaa ctctatagga 13800

ggatcaacaa tatgaagtaa ccactacccc cacagaactg agtctctagg tgtatatgta 13860

gcagaggatg gcctagtcgg caatcaacag gaggagaggc ccttgggaag attatatgct 13920

ccagtatagg gggtggttaa catgtagaga ttccacctca gaccagtcag aatggctaag 13980

atcaaaaact caggtgacag cagatgctgg catggatgtg gagaaagagg aacactcttc 14040

cattgctggt gggattgcaa gcttgtacaa acactttgga aatcagttta gcggttcatc 14100

agttaattgc acatagtact accggaggat tcagcaatac ctttcctgtg cattggagaa 14160

aacagaaaac tctgagatgg aagctctgct gctggctctt gtgtttgctt ggatttgttc 14220

tagaagtggg tcgaatggac agctcaatga aacccaggta tcatgaaata ataagtataa 14280

tatataaaaa attcttattt cattattcat ttatctcaaa tgctgagcaa cacctcaata 14340

tcatttacta aatatttatg tactagagaa atcactcatt cagggagcaa gtcaggggaa 14400

atgcaacact ctaaatagaa tatgatttaa tatttagttt catatgactt aatatttaat 14460

atttttattt tagacatttt acatttagac tttcacacac acatatatat gtatgtatgc 14520

atatatatat atgtatatgt atataaacag catgcaaact gcaattacaa acattaaaat 14580

ataccagata aaatgttagc cttattatat gcccattgta gtattatgat ttcaaaataa 14640

aataggatat aattacatgt cttcatatta atcactcatg taaaaataat attaaatgtc 14700

agcatctcgt cacctgtgtc tatttatccc tctgttttcc tcaaagagat ttatataaat 14760

gtcagattct gtaaaccgtt ggttcacact catgtctgca ttgaaaacaa atattattta 14820

ctgtcaattt tatattttct catttctatt tagagcagat tttaggtgat aaaacccaga 14880

gaccaaatga aatattttgt tttctgtgat atttgttaac tcagtcttaa atatgtcaaa 14940

agtctttcac cgttatgctt taaatgtaga tttggacaat tgtgtcacct tttgtttgta 15000

cacttcaggg aacagaaaat ttactctgta tttaggaatt gtattattga ttgtatgtca 15060

cactatacaa taaatggaat atgttcaatt gcatttagta atttttattt tttttcctgc 15120

aatacatttt gattgtattc attcctctca actctcagat cttcccccac ctccctacct 15180

acacaaattc atgttctttc tctaacaaaa atatggaata taagtttttt ttgtttttta 15240

tttttttttt tttttgagac agggtttctc tgtgtagccc tagctgtcct ggaactcaat 15300

ctatagacca gactggcctc gaactcagaa attcacctgc ctctgcctgc caagtgctgg 15360

gattaaaggc atgtgccacc actgcccagc tagaatataa gttttttttt aaagattttt 15420

ttatttatta tatgtaagta cactgtagct gtcttcagac actccagaag agggagccag 15480

atcttgttac agatggttgt gagccaccat gtggttgctg ggatttgaac tccggacctt 15540

cggaagagca gtcgggtgct cttacccact gagccatctc accagcccta gaatataagt 15600

tttaaggagc agaattgtat acttctcatt aaaaatcaaa aatttcccct ctcaagctaa 15660

agtatttgtt ggagatgaaa gaaaacatcc atttattttc ctaatggcat cttcattctc 15720

agatctcagg tgattggtac accattgcca tagcagccac agatcttgat gtgatcaccg 15780

atgatggatt gttgaaactg tttttccgtc atcttgagtg tactgaacaa tgcaaagaaa 15840

tcatcctgac attctatggt gagtaagcta accttgctgc aatctaaagg ttcagacatt 15900

ttgatatgat aggaggtatt gacacatttc ccagactgac agtttcatga cactgtcact 15960

taccacaata tatacataat tccaaaatag aaaataatgc tgaggtattg ttccacattt 16020

caaataaaat acatttaata tgaatattta tgaatggtaa tataaacaat attaatatta 16080

ctaaaatatt taatatttat aatgtatgtt tcctatacat ttaaattatt taaaacagca 16140

tgcatattat aatgacaaat gatattcggt atactggata gaatgtatgt catattgtat 16200

atatgattac aatataaatt atgacttaca tttatatatg attacaatat aaaatgagtt 16260

gtatactaca tgtatattaa aatgaacatg ttatgtgtgt acttacaata ttgtatttta 16320

tataatatca tatttcacat taatatcaaa ttttgtggct ctatactaca gaaaatatca 16380

ggctagaaaa aattgctcag tgaataaagt acttttaaat ttatttataa cattgtgtta 16440

ttttatgata acatacacat gtcactatgt aaaaattatt atatttatat gtcatatatc 16500

atactttata ttttaattat acctatatat tattgtttgt tgttaaagat ttgtgtttta 16560

tggtattcct gtttgtgtga aagtgtggat ctctgcatct atatgtgttt cttgtgcttt 16620

ttctttgtct cttgtgtttt ttttttttct gtttctttgc tttgccctca tctggtttgc 16680

ttttatttat ttatttcttg tctttagtat gcattctcat tttctaatga aagaaagtgt 16740

gagaatttgg atgggtggaa aggttgggag gatatggaga tataggaagg gaaaccataa 16800

tcagaacata gtatatggaa atattctttt aattaataaa acgatgggtt ttagttatat 16860

caagtgtctg gaaattagtt ttaaatagtt tttcatagtt ttaattgtta attccagtca 16920

tagaagtggg aagtatttca gatggaaaaa tagcatttgt atcactaagc agcttgtgac 16980

caagaccatt tcagatcttg tgggtaagac tgtcaatcac ccatagctgg aatggttgac 17040

aattaatggc tcctggggga ggaataatta tattacttta agaatatagt cacttgtggg 17100

tttacattca tgcacatatg ttcaatgata actggacata attggttact tctttaaaat 17160

gaaaggagga aagggagaga gaatctggga tttggaagga ctggactaga tgaaggtgga 17220

tccaagtatg ctcttgcatg tatggaattc tcatatgtac agcagtgact ggaagtatat 17280

aaacttcaat agcaataaat tcaggacata tagagaaata ggaaagcaga aacagggggc 17340

tatataagat cacattttat tttatgtgtg tatgggattc tacaaagaaa agttaaagtg 17400

aaatataaaa gtacttaaaa taaattcata gatcagcata caattaggac tagggtaaat 17460

aaagatccca tatcccctaa agaaatagaa gcagttatta atagtctccc agccaaaaaa 17520

agcccaggac cagatgggtt tagtgcagag ttctatcaga ccttcaaaga agatctaatt 17580

ccagttctgc acaaactatt tcacaagata gaagtagaag gtactctacc caactcattt 17640

tatgaagcca ctattactct gatacctaaa ccacagaaag atccaacaaa gatagagaac 17700

ttcagaccaa tttctcttat gaatatcgat gcaaaaatcc ttaataaaat tctcgctaac 17760

cgaatccaag aacacattaa agaaatcatc catcctgacc aagtaggttt tattccaggg 17820

atgcagggat ggtttaatat acgaaaatcc atcaatgtaa tccattatat aaacaaactc 17880

aaagacaaaa accacatgat catctcgtta gatgcagaaa aagcatttga caagatccaa 17940

cacccattca tgataaaagt tttggaaaga tcaggaattc aaggcccata cctaaacata 18000

ataaaagcaa tctacagcaa accagtagcc aacatcaaag taaatggaga gaagctggaa 18060

gcaatcccac taaaatcagg gactagacaa ggttgcccac tttctcccta ccttttcaac 18120

atagtacttg aagtattagc cagagcaatt cgacaacaaa aggagatcaa ggggatacaa 18180

attggaaaag aggaagtcaa aataacactt tttgcagatg atatgatagt atatataagt 18240

gaccctaaaa attccaccag agaactccta aacctgataa acagcttcgg tgaagtagct 18300

ggatataaaa ttaactcaaa caagtcaatg gcctttctct acacaaagaa taaacaggct 18360

gagaaagaaa ttagggaaac aacacccttc tcaatagtca caaataatat aaaatatctc 18420

ggcgtgactc taactaagga agtaaaagat ctgtatgata aaaacttcaa gtctctgaag 18480

aaagaaatta aagaagatct cagaagatgg aaagatctcc catgctcatg gattggcagg 18540

atcaacattg taaaaatggc tatcttgcca aaagcaatct acagattcaa tgcaatcccc 18600

atcaaaattc caactcaatt cttcaacgaa ttagaaggag caatttgcaa attcatctgg 18660

aataacaaaa aacctaggat agcaaaaact cttctcaagg ataaaagaac ctctggtgga 18720

atcaccatgc ctgacctaaa gctttactac agggcaattg tgataaaaac tgcatggtac 18780

tggtatagag acagacaagt agaccaatgg aatagaattg aagacccaga aatgaaccca 18840

cacacctatg gtcacttgat cttcgacaag ggagctaaaa ccatccagtg gaagaaagac 18900

agcattttca acaattggtg ctggcacaac tggttgttat catgtagaag aatgcgaatc 18960

gatccatact tatctccttg tactaaggtc aaatctaagt ggatcaagga acttcacata 19020

aaaccagaga cactgaaact tatagaggag aaagtgggga aaagccttga agatatgggt 19080

acaggggaaa aattcctgaa cagaacagca atggcttgct ctgtaagatc gagaattgac 19140

aaatgggacc taatgaaact ccaaagtttc tgcaaggcaa aagacaccgt caataagaca 19200

aaaagaccac caacagattg ggaaaggatc tttacctatc ctaaatcaga taggggacta 19260

atatccaaca tatataaaga actcaagaag gtggacttca gaaaatcaaa taaccccatt 19320

aaaaaatggg gctcagaact gaacaaagaa ttctcacctg aggaataccg aatggcagag 19380

aagcacctga aaaaatgctc aacatcctta atcatcaggg aaatgcaaat caaaacaacc 19440

ctgagattcc acctcacacc agtcagaatg gctaagatca aaaattcagg tgacagcaga 19500

tgctggcgtg gatgtggaga aagaggaaca ctcctccatt gttggtggga ttgcaggctt 19560

gtacaaccac tatggaaatc agtctggcgg ttcctcagaa aactggatat agtactaccg 19620

gaggatccag caatacctct cctgggcata tatccagaag atgccccaac tggtaagaag 19680

gacacatgct ccactatgtt catagcagcc ttatttataa tagccagaag ctggaaggaa 19740

cccagatgcc cctcaacaga ggaatggata cagaaaatgt ggtacatcta cacaatggag 19800

tactactcag ctattaaaaa taatgaattt atgaaattcc tagccaaatg gatggacctg 19860

gagggcatca tcctgagtga ggtaacacat tcacaaagga actcacacaa tatgtactca 19920

ctgataagtg gatattagcc caaaacctaa gatacccaag atataagata caatttccta 19980

aacacatgaa actcaagaaa aatgaagact gaagtgtgaa cactatgccc ctccttagaa 20040

gtgggaacaa aacacccttg gaaggagtta cagagacaaa gtttggagct gagatgaaag 20100

gatggaccat gtagacacta gcatatccgg ggatccatcc cataatcagc ttccaaatgc 20160

tgacaccatt gcatacacta gcaagattat gctgaaagga ccctgatata gctgtctctt 20220

gtcagagtat gcctgggcct agcaaacata gaagtggatg ctcacagtcg gctattggat 20280

ggatcacatg gcccccaatg aaggagctag agaaagtacc aaagaagcta aagggatctg 20340

caaccctata tgtggaacaa cattatgaac taaccagtac cccggagctc ttgactctag 20400

ctgcatatgc atcaaaagat ggcctagtcg gccatcactg gaaagagagg cccattggac 20460

acgcaaactt tatatgcccc agtacagggg aacgccaggg ccataaaagg ggagtgggtg 20520

ggtaggggag agggggtggg tggctatggg ggacttttgg tatagcattg caaatgtaaa 20580

tgagcgaaat atctaataaa aaatggaaaa aaaaaaagaa agataagatt gcactaaaga 20640

tcattgtgac ttcaatgaat gttggccacc atgtgcaaaa tgggtttaga tgattttaac 20700

taacctaact ggaagtataa atcaaaaaag ttaatgctga aaaaatttac tcataataaa 20760

cgttatttga ggtttagcag cagggaagtt agcatggatt ctgtgtgaag agaaaagaat 20820

gatattgttt attttctgta caataacttg ttctcagtta ataataaatt agagattata 20880

catcaagaag aattctagaa acatgtcatt gaataataca tgtgaaaatg aatctgtttc 20940

ccattttata aatataatta gaatctatat gaaggcttta atatcccatt ccttgcttct 21000

ttcaaagtgt tcattattta agatggcact attgaaatct gagtagaaaa aaatggcata 21060

aaatatatca ttacaaccca gtaacaacaa agacacatat gaattataga tttcatatat 21120

aactgatttt gtattcctca gatctatatc tgatatgtaa atacaattat ctgcttgtac 21180

atttactgtg caggtctata tgcccatccc cacctagaat cactgatgtc tatataaatt 21240

tttgctgaat aaatataagt tgaattaaca gaagtcaaat tatgcattag acaatggtag 21300

attcagtggg gtatagtagc acatgccttt aatctcagca cacatgaggc agaggctggt 21360

gtctctgtgt ttgaagccgg cttggtctac agagttccag gatagccagg tctgttaaac 21420

agataaacca tgtcatagaa aaaaagaaag aatgaaagag caaaggaagg aaggagagaa 21480

ggaaggaagg aaggaaggaa ggaaggaagg aaggaaggaa ggaaggaagg aaggaaggaa 21540

ggaaggagaa gaaggaagga aggaaggaag gaaggaagga aggaaggaag gaaggaagga 21600

aggaaggaag gagaaaaaca aacaaataat gatgaattca gtgacctaga aacagaagtg 21660

tttatagaag atagttagat agatagatag atagatagat agatagatag atagatagat 21720

agatagatag atatagatgc tttaaaaaaa agactacaca tatcaaagta atctgcagct 21780

actaccaggt aaagtatatt gatatcgttg cttgaaccat tgcacataaa caatcctcag 21840

tgacaaagtc aactgttgtg gtttctatgg cacagtgagt cagtgtccag tgatctgaga 21900

aggaagatgt tcgttatgcc catcattaca ctattcaggt cacacaggac catgataagg 21960

gatatacata tctgtctctt tttgttttag ggtagatgaa gaatgtgaaa agtttgaagc 22020

taacgcacag acctaccaat cagatgggtt tacttttacc tgtgagtata tgtgatcttt 22080

ctggaatatt taaattcctt gttactggta tcatcccata gcctgagcct ggaagaattt 22140

cttcttgcag ctttccacca ggccttacac ctctcactgg gtctgtgaag aagtcaggat 22200

ctcatcacac atgttacatt aaattgccaa aataaatgaa caaaactctc aggtcttatt 22260

gtgagatgtt cacatataaa acaactgaga atatatttta tgtagagtaa tttaagtctc 22320

acttacataa taattattgc gactattcaa taaatagtca agttggtcaa taaaaaataa 22380

atatgtaggg caagagtgat ggtcagcagt taagggaggt tgctgctctt ccaaaatttc 22440

cctattctgg tcacagtagt cacatttgat ggtgcacaac attctgtaac tctggttttt 22500

ggagatccaa tgttttctac tggactcgaa gaacaccctg gtcacatgca aaagaaaaac 22560

aaaaacaaga caaaaaacac cacaagtgca cctttacaca tagatgaaaa taaaatcaat 22620

ttttaaaaaa gataaaatat tcaagtgttt ggaaagacat ttgataaaaa gagtttggca 22680

agtacattat aattagcaga catcagaagt taataatggc agtgattaaa atgacagatt 22740

gaaatattca taccaaagtg tacttaattt aaaattcaat cccaatgaga agaaaactgt 22800

ataggttttt gtttgtaata attggcaata atttgcagta atcagttttc taaaatggaa 22860

tgaccaagtg cttaagtaac ttactttgta gaaaagtgta caatatatta ttctcatctc 22920

agtttgaaaa atatctattt ttaacttaaa tgcaactgag gggattatta atgaatcagt 22980

gacactgaag aaggaagggg acgcatttct ggggtccttg aattgagcct gctaaaatga 23040

aatggaatag tgttaaaatg tttgaattct gacatctacc tttttacact acagatccag 23100

gtgagtgtta ctttaggatt tcatatatat caagtgcaag tatgatactt attagttact 23160

gtttgaagga tggtttgcat tggaaatccg cactcatttt gcttggtaag tatcatgact 23220

ccttcttatt atgatgacga ttattattat tactctttct tatgcctgca tatgggtctg 23280

cataccacat gtgtgcttgg tgtacacaga caccagaaga gagcatcaga taccctgcaa 23340

ctggaatgac aaatggttgt gagccaccac gtgagtgatg ggaattgagc ccagtttccc 23400

tgaagagcag ccagtgctct taacctcagg accatttttc cagccccacc tagatctttt 23460

tctataatac agaacatggc tacattatgt ctgcttttga tttaaaagaa aaatttatgc 23520

ataggttgtt tatataaaat gtatttattc atagatgtgt ctacatagga gattcaatat 23580

tccccttgac tgaatcaagg atgcaaaaac attttatcaa aaataaagat ttatgtccac 23640

cagggacttc catcagaaag atttccttaa attggacaca tacaacgtgg tgatacaaga 23700

cattccatgg tgcccttatt gaagtatcag agttcactca ttggtagatg gcttagggaa 23760

cctcataatc caaaaataaa aattttagtt tagatgcttt aaaggaaaat catgttaggt 23820

ataagaaata tgaaggggga ggattttttt attgtcttgt ttctggaaag ttgacattat 23880

ttactccccc ctcattccat caggggtctg gagtaggcag gaatggatat gatgataata 23940

atataggttg agtaggaaga aaaagtcatt attttggaaa ccttctgaaa tcttaaatgc 24000

aactaacttg aattccaaag tggttatgtt tagagaatac tactacccag ggagctatta 24060

gaggaggaca gggaatgtgc tcaagtcaca ggagcatatc ctatgtgctt agaatgtatt 24120

caattgtgaa ctcaataggt ttacaactgt gaatgatgtt tttgtgaact caataggttt 24180

acaactgtga atgatgaaat gatgttccat gtttttagtc cttgtcaagt caccatgaaa 24240

gacagaggtg ggagtgagga gaggattgga cacacagtaa gataacatgg aggatacatt 24300

ctactctgaa gaacattcca catgattctc ttcatttttt ccacacaatg aagggaaagg 24360

aaatggtgtg agtgaaattt acagatgagt gtactaggag gatacttcca aaggagaatg 24420

taagatatgt gcttgagaaa ggtaataagg caatgaccat agaggatacc ctagatgtcc 24480

cctgagactt tatatgaaat aaaaaattta aaaccatatt atatttgatt caaatttact 24540

actcaacaat ttttgaagtt ataatcctta aaacaatgtt gtttcccacc ctgttttgca 24600

gatatttgtc ctaaataagg acatgcatac cttgggtgag tagaaacata atgacagatc 24660

ccattcttac taaaaatcaa tgctttttta tttttatcgc ttcttggcct tttggctgag 24720

atcaagtgta ttttttattt gttactttta tgaaaaaaaa aatcgatggg tggatgtgat 24780

gtgggtgcag tgctgttgga aaacagaaga tggcaccaga tcccacagac tcacatggag 24840

ctgagacata agtcttgtgc aagatcagag atgactcttt tttttttctt tccatttttt 24900

attaggtatt tagctcattt acatttccaa tgctatacca aaagtccccc atacccaccc 24960

acccccactc ccctacccgc ccactccccc tttttggccc tggcgttccc ctgttctggg 25020

gcatataaag tttgtgtgtc caatgggcat ctctttccag tgatggccga ctaggccatc 25080

ttttgataca tatgcagcta gagtcaagag ctccggggta ctggttagtt cataatgttg 25140

atccacctat agggttgcag atccctttag ctccttgggt actttctcta gctcctccat 25200

tgggagccct gtgatccatc cattagctga ctgtgggcat ccacttctgt gtttgctagg 25260

ccccggcata gtctcacaag agacagctac atctgggtcc tttcgataaa atcttgctag 25320

tgtatgcaat ggtgtcagcg tttggatgct gattatgggg tggatccctg gataaggcag 25380

tctctacatg gtccatcctt tcatctcagc tccaaacttt gtctctgtaa ctccttccaa 25440

gggtgttttg ttcccatttc taaggagggg catagtgtcc acacttcagt cttcattctt 25500

cttgagtttc atgtgtttag gaaattgtat cttatatctt gggtatccta ggttttgggc 25560

taatatccac ttatcagtga gtacatattg tgtgagttcc tttgtgaatg tgttacctca 25620

ctcaggatga tgccctccag gtccatccat ttggctagga atttcataaa ttcattcttt 25680

ttaatagctg agtagtactc cattgtgtag atgtaccaca ttttctgtat ccattcctct 25740

gttgaggggc atctgggttc tttccagctt ctggctatta taaataaggc tgctatgaac 25800

atagtggagc atgtgtcctt cttaccggtt gggacatctt ctggatatat gcccaggaga 25860

ggtattgctg gatcctccag tagtactatg tccaattttc tgaggaatcg ccagacggat 25920

ttccagagtg gttgtacaag cctgcaatcc caccaacaat ggaggagtgt tcctctttct 25980

ccacatcctc gccagcatct gctgtcacct gaatttttga tcttagacat tctgactggt 26040

gtgaggtgga atctcagggt tgttttgatt tgcatttccc tgatgattaa ggatgttgaa 26100

cattttttca ggtgcttctc tgccattcgg tattcctcag gtgagaattc tttgttcagt 26160

tctgagcccc attttttaat ggggttattt gattttctga agtctacctt cttgagttct 26220

ttatatatgt tggatattag tcccctatct gatttaggat aggtaaagat cctttcccaa 26280

tctgttggtg gtctctttgt cttattgacg gtgtcttttg ccttgcagaa actttggagt 26340

ttcattaggt cccatttgtc aattctcgat cttacagcac aagccattgc tgttctgttc 26400

aggaattttt cccctgtgcc catatcttca aggcttttcc ccactttctc ctctataagt 26460

ttcagtgtct ctggttttat gtgaagttct ttgatccatt tagatttgac cttagtacaa 26520

ggagataagt atggatcgat tcgcattctt cgactcttat ccattgagtc tatcagccat 26580

catactatcc ttctctactt aatttgctcc cttgagatct caagataaag agtcaatatt 26640

ttaattttgg aaacaaagaa atccgtgaga tatgaaataa tgaagtttag cgtgaattct 26700

gggcagccaa atagtttgca gcttttggtg atgcacatat ttatgcattt ttctctgtgg 26760

tataaatctc agtatttacc ttggatatat gaaatctcag gatttgttca gaggtttaca 26820

aaattaatat aattttatga aattcttcaa aataatatcc atacatggca tccatgtaca 26880

cagatggaat cccatgaagc aactttgtca tggacaaagg tccactttgt aatggatagg 26940

gtctactaag atccaacaca actcagacac tgaatcaata cagaaaacaa aaatttattg 27000

taatcaaact gctactgatc aatcagcaac attgaacaga cttgggagct gaactatagt 27060

ccccagccaa aatgtttaca gggctttagg cctgaaagac acaaatatct atgtcaagtc 27120

acagttaaat ttttccatca attgagattc aggtataggg gacttttcta gaaacatttc 27180

tttgtggtac atttatcctg tcctcattgg ttagtttact taactgtggc agagtgactt 27240

gcccagcatt catgtctcaa cttgtcaacc aaggtgtcgg tcaccctggg agatcttaga 27300

aacttaaact ttgtttgaac cctattcaaa atggaagatt tattcaaaat ggctctttat 27360

tacaaatttc cctctgatac attgctcatc aaaggaatca attataaagt tatttaatgg 27420

catataatat ttatatatag aactgagttt cataatgaca ttctttatac atgtatatca 27480

tacattttaa tcatatttcc cccctttatc tacctcttat tctaacctgt tgctttcctc 27540

atcccaacag ccgagtcttc attctacttt cacacacaca cacacacaca cacacacaca 27600

catatatgtg tgtgtatgtg tgtatgcata tatgtattgt atataaattt tattatagag 27660

tatagagcat attatatatt acattcacta tattatacat tgtcttgtgc attatattat 27720

atatatatga actttctggt gacacaatca atttaattag gactgcttgc ataagcatgt 27780

gtacagactt atttacagga gcatggacac aacatcagca tctagatcac taaaaatcat 27840

ctcaggctcc ccctaacaac catgacttgc ctgtaaagtc tcagaaatgt ttggggcctt 27900

gtgagtgagt ctcctgaacc acccagcaac ttttattatc tataatccct cagaagaagg 27960

gggaccacat gaaccctgcc aattccacca atttggttca ggtcttcctt cattgaaaac 28020

ttaaggacat tatgctacta agaagaactc aactaaatta aacattttca ttctcatctc 28080

cacagatatt ataaagaata tttgaaattg taacttctca atggcaattg attcatctct 28140

gtgaagtcta attattctgc tccccatcct atgaagacct aagtcccaat ttattgcttc 28200

ttttctttcc tgcatttatc ccttgtatga cgttactaac ttactgatta aattgatact 28260

gtatgcatac acacatatca gaagcatgct cttaaagttt ccaatgctta aaaatgtttc 28320

actatgcaca actcttaaaa aatatactca tctattatca agcaggataa atgtacttaa 28380

aagaatagtt aaagagttgt acagatgtct tagtcggtgc tcactaaaac ctgtctattg 28440

cctctagctt ctggggtagg atgtgtctca tgagcactcc cctacctagc tataattgca 28500

tggtcaggcc tcgcacacat aaccacatct gctttgagtt catgagcaca catcaccaca 28560

tctgctttga attcatatca atgggcactg cagaaattaa aaaaaaaaaa ccattaggtc 28620

ttacttcaaa agcctgtact tcacaaaatt ggaaaatcta aatgaaatgg atgattttct 28680

atatacatac cacttaccaa agttaaatca aggtcaggta aacaacttaa aaagtcctat 28740

aactcctaag taaatagaca aagtcattaa aatattccca accaaaaaaa caaaaagccc 28800

agggccagat tgttttagtg cagaattcta ccagactttc aaacaagagc taataccaat 28860

atgcctcaaa ctattccaca aaaataggaa cataaggaac actacctaat tcattgtatg 28920

aggccaaaat caccctgata cctaaaccac acaaagactc aacaaacaaa agactctcag 28980

accaatttcc cttatgaaca ttgatgcaaa aacactcaat aaaatattag caaactgaat 29040

cagagaaagc atcaaaaaca tcattcaaca tgatcaagta acattcattc aaagggttgt 29100

agggattttt caatgtatga aaataaatca acataattca caatataaac aaactaaaaa 29160

aaaaaactaa tcatctcatt atgtactaaa aaaggctttg acaaaatcca atctctttca 29220

tgttaaaagc cttggagaga tcaggatacg agcacatatc taaatacaat aaaagcaatg 29280

tacagcaagc caatagtcaa agtcaaatag agaaaaactt aaagcaattt tactaaaatc 29340

agggacaaga cacagctgac cactctctcc acatatattc aacattgtac ttgaacttct 29400

agctagagaa ataggaaaat taaaacagat caaggggata caaattggaa aggaagaagt 29460

caaagtatca ctctttacag atggtgtgat agtactcata agtgaaccca agaattatac 29520

cagagaactc ctacatctga taaacacttt cagcaaagcg gctggataca aaattaactc 29580

aaagaaatcg gtagccctct tttatacaaa ttataagtgg gtcgagaaag aagttaggaa 29640

gaaaatacct ttcacaatag ccacaaataa tataaaatag ctaatagtaa ttctaaccaa 29700

gcaggtgaaa gatctgtatg acaagaattt caagtatctg aaaaagaaat taaagaagat 29760

atcagaagct agatcccaca tgcttatgga tcaattgaac taacaatgtg aaaattgcat 29820

ctctccctgc ccttatggat catcagacaa tactggtcca tgtggtcaaa gggaacagag 29880

atgagagacg agaggttaac atgccctgtg agtacataca gtaaataaga tacatcagaa 29940

ccagatgcag ggaggcagac aaactttacc tggggtgatt caagaactat ataatttggg 30000

gatgctagaa aaatccaaga tggccagagg tcattgactg aagacttagg gtactgaaat 30060

aattcactag catgggaaag tatttcacga atctcagatg ctagctgaat gagttcttat 30120

caagagaaat aaagggatat ggactccaca ggaaaaccaa cagagtcaac tgacacagac 30180

ccttgagggc tcccagagac tgaactacca accaaagagt aagcatgagc tgtacctatg 30240

accctacaca catatgtagc agatgttcaa catggtcttt atgtaggtct cccaacaact 30300

agagtgggga ttgtccttga ttctgttgcc tgcttgtgga tcctgtttcc ctgagtaggc 30360

caccttgtct gtcctcagtg ggagaggatc cacctagtcc tgcagtaact tgatgtacca 30420

gagtaaggtg atacccaaag aacacacacc ccttctcaga ggagaaacgg aaggggaggg 30480

gagctgtgtg agggtgagac taggaagaga gagaggctga gattgggata taaagtgaat 30540

aaataaatta acagaaaaat aaattggaga ggaaaaagtc aaagtattgc tagatggttg 30600

gatagtatgc ataatctcta caaaaattct accagggaac tcctacagtt gataaacatc 30660

cttcagcaat gtagctggat acaaaattaa ctaaaaaaaa tcagtatctt ttctttatac 30720

aaatttgaaa tgggctgaga aagaattggg gagacaatac actttacaat agccacaact 30780

aatataagat aacttggtgt aattctaacc aagcaagtgg aagaccccta tgacaagaac 30840

ttcaagtctc tgaagaaggg aaatgtggta catttattaa atgggatact cctccagaag 30900

gggaaataac atagacttgg gaaatgtttt ggaatagtag gacataggac tgagtgagcc 30960

agaggggtca aggacaccac aataagactc acacggtcaa ctaactcggg cctatggtag 31020

ctcacagaga ctaaatcacc aaccaaagag catgcatatg ctggaagtag gcccccctac 31080

acatttggag cagatgtata gcttggtctt catgtaggtc ccctaggaat tggagcaagg 31140

attgtctttg actctgttgc ctgcctttga aaccgctcct cttggctggc cttccttgaa 31200

gggctacact gggaatggat gcactaagta cttctgcaac ttgaagcacc aggactggtt 31260

gaggagaaag gatgaggtaa tgggggaagg ggtttgtgag ggtagtacta ggagaagggg 31320

aggttgtaat tggggtgtaa agtaaataaa tagatagata gatgatagat agatgataga 31380

tagatagata gatagataga tagatgatag ataggtagat agatagatag atagatagat 31440

agatagatag atagatagat agatataaga aagaaaattc aaatactaga atccatattg 31500

tgatctaacc atgtaaaatt ctttcttcct acttgatatt ataaggtatt ctttacccaa 31560

agaaaaatat tatttcaagt ctggtttcta ataccatgaa atataaaatg tgattgcagc 31620

attgggaagg taaatcaaat ttcatacagg agaagacatt tttcctgtct gatacttgaa 31680

atagtgtttt catgatattt ttcatgaatt tcactgctgc aaagatatat ttactcttgt 31740

gtttttaaac attatcataa tgaataaagg accttggttt tcaaggcata tacacctcct 31800

tcatggagta tataccactg caatccttag gcatttcaca caatgtaaca aatacaatat 31860

tggcccttaa ttaactacac aagcatgaag catcagggat gaattaatct caaatacaca 31920

cccagtatcc catcaaaatt atttggacaa taacacatca aacttatttc cctaaaggtt 31980

tacttttttt ctaactccat aagctcatcc atcagtcatt gttttaatat acccgatatt 32040

aagtcaatat cttaaatgta atgagatata aatttttttt ctgacaaaca agaagggaag 32100

gattatggat ttctattttg ttgctcataa ggaaacatgg gtgacataat gtgctagttg 32160

agccattcaa acaacatgga cttcagattt tgattttcgc actgagtgga tgatacaaca 32220

agaggtaaaa ttggaagatg cactacctaa aacaaagaga tacaaaccaa atctttaatg 32280

gtttttagac acatctttga ccatgaaaat atggcaaagg aaagttgtct ttaaatgtct 32340

tcattattat ctgaactcaa aaattaattc acatcacagt gttcacactg tgaacactaa 32400

gtcacacata gtctcatctt gtcttcagga gacttttctg ggaattatca ttattttgat 32460

aggggaattt agaagagata gttgggtttt acaaagtgac agacaactga ccaacagatt 32520

ctctatgctg ggttccaaat gacacttctt ccatttcttg ccatcaaatg cagtaagtga 32580

aactaatccc actaaagaaa tgtaaagact atgtaaattg aacaagaaat aaaaaactcc 32640

cataaaatta ttataaatat ctataaagta agtaatagca ttctttttgt ataaaataag 32700

ctgagaccag agaggtttat agattcttga ttccaacacc tgatttacaa aaaactgcat 32760

atatatatgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtatacat atatatatat 32820

atacatatac atatatatat acatatatat ataaaacaaa atcccttaaa gcattgatga 32880

acttcaataa ccttttctct atttgtacat tttaattttt ctcttatttt ttaaaagtag 32940

aacataattt cttttttctt tagttttaag aatggtgaca ataaattaca taataataaa 33000

gagataagaa agaaaacaca tcagtcagca caatttgagt ttgcttacta agactgtttc 33060

tctcaacaga tgcagagtcc catagcaaaa ccttaggcag agcttgggga gtcctgcaga 33120

ggatggggag gaaggatcac ctaaccagag gagtcaggga caccaaaagg acaaggctca 33180

cagaatgaac tgacatggag gctgtcagag atcagggagc cagtaggggt ctaataggcc 33240

ttgggtgtat atgttatggc tgagtgtagc ttatgttctt ctagggttcc taacaatgga 33300

agtaggacct atctctgact cttttgcctt cttatgggat cctttcactc cttttgggtt 33360

gcctagcaga gccttgacgt gatggtatat gcctgatctt attgtaactt gttataccgt 33420

gtttggttta aattgctggg aggcctgctg tttttggaga ggacatggaa gggatggata 33480

tatgaaagag gggaggtaag agagacacag agggaagggg aggaaggaga aactgcagct 33540

aggatgtaat atataacaga agagttaatt aattaattaa attttaaaaa agcctgtggt 33600

ggttttaata agctcagccc aggcagtggc actattagga ggtgtggcct tgttggtgta 33660

ggtgaggctt ccttggaagt agtgtgtcac tgtgggggtg agctttgaga ctcttctcct 33720

agctgcttga aaacagtctg ctcctggatt cctttcaatg aggatttagg gctctcagct 33780

cctccagcac catgtcttcc tggatgctgc catgcttccc acctggatga taatggactg 33840

aatctctgaa cctgtaagcc agccccaaat aaatattgtg cttcctaaaa tttgacttgg 33900

tcatcatgtc tcttcatagc aatggaaacc ctaactaaaa cagagcctct ctggctctta 33960

agccatgctg gctataaagc ctcacatatt acatgacata ttattataga aactttgtat 34020

cacaccctga atatcatatt tacaatattg taggtaatat tttcctctct aattatgaca 34080

tgtaaatgaa ttacgtaatt atactcaaaa gaatttcttc tgacattatt gactacctta 34140

ggttttgttg catttttatg tgtttattat tttatttgtt ttgttttgaa acacattcaa 34200

actatgttag caacggttat cctcaaactc aatatataga tcaggggggc ctcaaactca 34260

cagaaaacaa tatgactctg cttcccaaga cacagaatta acagtatgga tcaccatgct 34320

caattaatca caggttaatg tattttagtt tttaattatg tagatattca ggtatctgca 34380

tatgagcaat gttaccaggt gagttcagta cctgacgagg gcagaagagg gagcagattc 34440

ctctggacct aaaattacac atgattgtgc attgcaatat agttgctagg aactgaaccc 34500

aggtcgaaag gaaagctagg actctgaccc agtgagtcat cctaagccag attatttttt 34560

aataggtaca gtgcacattt tctttgttgt gtatgatggc tagaatatgc ttgccctatg 34620

gaaattggca gtatgaggag gtgtgtcaat gttggggtag gtgtgacctt gttggaacat 34680

gtgtgacact gtgtgagtgg gttttgaggc tcctatgccc aagctctgcc aaatgaggaa 34740

gagagcctcc tgctggctgc ctgcagaaga aagactctcc tggctgcctt tggatcatga 34800

tgtagaactc tcagctcctt ccccagcacc atgtctgcct gcagactgct atgcttcctg 34860

ccatgatgat aatcatgaac ctctgaacct gtaaggtggc cacaatgaaa tgtttgcctt 34920

taatagagtt gccttggtca tggtgtctct tcacaaatat atacccccta attcagacat 34980

tgtgtattac atcacattga ttgaagacag aatgtgtaca tgaaaaatca atttatttta 35040

tcaacaaaag aatcagtacc atggtaggag tatgggaaac aaatccatga agcagagatt 35100

ctggcttcat aggaaagatg aaaagaaaaa ctaagaaaag gatgagctct cttcattgtc 35160

atgattctga tttcatgaaa gaggtgatgt gggaaatact tctgatcttg ctgtcatctg 35220

tgaagcttca aaagtaaaaa acaagacaaa caaatgaaac agtaagatgt gcatgagctg 35280

gtgcttctga catgagcttt ctgagattgt aaatgaaaaa caaaaattaa tcgacacgga 35340

atatggtgaa aggtttgatt ttaaaaatga cacatgtcac agggttagac ctaggtttgt 35400

tcttggttga cttccataac tctcttccgg catttaaact gagagttttt ggtctaaatg 35460

taatctacca taacacctat gtgcaaggtt gtgtctaagg agactttaca aagttcatgt 35520

acatttacag tatttccaca ttcatgctac actcttggct gtcacaaata tcacttattt 35580

tcaatagtca agtttcatta aattcttacc tattaccttt aagataaaag aaatcaacac 35640

tttggtatag gagagttgct tattcccatg ttataaatat taacagcaac ataaacgata 35700

gctttgccac cttggattat atatgtaatt agaattataa agagatttcc tctactaaag 35760

gcataactaa tagactaaag aatgaatttt tagcagatta aaatattaac aggctctgct 35820

gccctgttgt actcacccat attgtgtctt tattggttac aagtgtctgt gagagacaga 35880

aaggaaggaa ataaccacaa acaaaagaca tagttagagc tccttaatat ctccagtgac 35940

tttaaataat tttaaaaatc tgatttagac gactgaaatg atgattatcc tggatatctt 36000

caggtgcatt agtttgctgt gtgaagcaca atgttgttac ctgtgggcgc caagtgctgg 36060

atattctcct ttggaatatt gtattccttg accagcttcc caagctcctg cttctgtgct 36120

ttgctcaggg tctctccttt tcctacatca cataaagcag aaaggaagaa aaagtgtagc 36180

ttacagtact gggtggctca gaacagatgg agttataatg ggttgtgtga tattgatgca 36240

tggaaacatc ttactttgtg ggccctccct caccccatca gtctcattct gatcaaccta 36300

agatctctaa agtaaaaaga acacatttaa tgaagctgaa ctatgatagt ccacacccta 36360

atgaataata tcgttatttg tggtggaatt gttattgttg ttattgccat catcactatt 36420

aatactccta ctactactat tataattatt cgtactttcc atatgaccgt atatttattt 36480

ccaaaaaggc ctgtacataa tcctggtgtt tgaaatactt gaactaaatg tttgtccatg 36540

ctgacttcta ccttacttct gtgtagattc tggagtccgt gccttggata attgataatt 36600

atcaaaataa gcagtgaaat caggctgaac aggctcatga acctgaatca attacgactc 36660

caacaccacc ccacctcacc acttacccaa cctcactacc agattccagt acccagtacc 36720

cagcctccag tcccctgcct ccaggcccaa gcccccaaat tgcctctgct tcctccattg 36780

cccctcacaa ctttggtaaa caaagcaaga ttgttgggtt tatatatata tatatatata 36840

tatatatata tatatatata tatattatca tgacacaaag caaggtcatc tggaaagagg 36900

taacctcaat taagaaagtg ctaccctcag actgctctgt gagaaacctt gtagactcat 36960

tttctagatt gacagttgat atggaagtgt ccaccccact gtaggaaact cagcagcaca 37020

gttttctttg ttagtgtttg atggtagggt gcctagacta tgggtagtgc cacctctggg 37080

gagatggtcc tgggtgctaa gagaaagcat gctgaacaag acctggggag caagccagta 37140

agcagcactc ctccatgccc tgtgcatcag ttcctgcctt caagttcttg gctgtttggt 37200

acagagacag atgggtcaat aattggaata ggattgaaga ccccaaaata cccccaacac 37260

acacacacat ggacacttga ttgttgacta agaagacact accatatagt agaaaaaaga 37320

gagcatcttc agcaaatcgt gctggcctac ctggtggtct gtatgaagaa gaatacaaat 37380

tgatacatat ttctcaccct gtacaaagca caagtccagg tggatcaaaa tcctccacat 37440

aaaatcatat atactgaatc taatagaaga aaaagtagga aatagcttgg aaggtattgg 37500

cacaggaaaa aattttctga accaatggct cagctctaag atcaacaatt gacaagtgga 37560

acctcataaa actgaaaagt gtcttcaaga caaaggacac tgttagtagg aaaaacagca 37620

acctacagat tgggaaagaa tcttcacaaa ccacacatcc aatagagggc taatatccaa 37680

aacatacaaa gaactcatat attagactcc agaaaaccag acaacctagc caaaaactgg 37740

ggtacaaact aagcaaataa ttcttaacta cggagacttg aatggctgag aagcaatgac 37800

ttctttttga aaatgaactg tgttatagga gcttaagcca aatcaaccct ttcttcccca 37860

agttgctttt ggtcatggtg cttatcatat cgatagaaac cctacaagag ggaccactct 37920

caccagcaac taaaatcaca tttgtctcct gtccgctctc atccacatta acgttgtgaa 37980

agaaaagggc gccatcttcc ttcattacaa cttcgaagta atttctacca gagtctgcaa 38040

ttaaaagaga atcagcttag aaatcagtag aatcattgga ggtttcacta ttattttaca 38100

tatgaaatct atgatatttt tatttctttt tcaattattt gacaaatgtc atttacaatg 38160

gtttaaaatt gtaaatgaga attactaagt ggtagagaca ctcttgcatt aattaaaata 38220

tttttttgaa tttaaaaaga atgtccataa ttagacggga atgctggcac acgcctttga 38280

tcccagcact tgggaggcag aggcaggtag atttctgagt tcaaggccag cctggtctac 38340

aaagtgggtt ttaggacagc cagggttata tagagaaacc ctgtctcaaa aaatgaaaaa 38400

aaaagttcat aattacctta tgtctccaca gcctatttaa aaagtgaaca caacgctaat 38460

attaaaatac cacactgaag cagggatggt gactcaaaca tcaaatccca gcaatcagga 38520

ggatctctgg ggctagcctt gtcgcagaac tagttatagg acagccaggg ctatgcagag 38580

taactctgta tcaaaaaaaa ttttaaaaac aaccacaaat gtgtctatgt atgtctgtgt 38640

gtgtgtgtgt gtgtgtgtgt gtgtagcaaa tgtatagttt tccatatatt aaacccttaa 38700

gaaatcagtc ctgtagcttt atgggactgc cttctaaatg tcatttatac ttaaataata 38760

ggcacaaaaa tgtctctaat aatacttttg tatgaatgtg tataatacac cttaactgat 38820

aacataaatg tctggaagtt tagttaggat tttggaagtt gcatcaaaaa ttatcagatg 38880

aaattgttca aggatcctgg ccctttagtt gtgcggcctt gtcaaacctt gcaaaatttc 38940

tctctgtctc tctgtctttc tgtccctccc cccctctctc aattagatta tgcatcccat 39000

taattgatta catactcaca gtcagtagtg taccgcccat cttcttgttt ttctcccaca 39060

acagtgtgtg tctgacactt gccattcatc cttcagaaat aaaaatcaaa aacttgcttc 39120

tgaatttact ctttcaggtt gctcatattt ccttattgtg tggtagtatt aactgtcttt 39180

gggaagtgtt taatttgttt aaataaaccc acatctgaag actgacacca acactctggg 39240

gttatgattg acatggaaag taaatccagg cttccagggg aagacactgt cctcattttc 39300

tacccacatt tcctgttcat gactagtttc aaccagaatt acccaaccct gtaaaactgt 39360

agaacacatt gcattcagtg ttccttaaat caaggacaca actcagaata aatatgccca 39420

ggagatcaat tccatttttt cacatggccc aagtgtcagt gaaaatttca cagacattca 39480

tgtgcccagt ttctcagtcc tgtccatgtg catcaggtga atgtcactta ctggacatgg 39540

aatttgattt tgagtgtccc acagtcgtca ttgcactcca tatgctcaaa gtacgctctc 39600

aggtctccat tcatctttac tttctccacc ttgtccgcag ctatgtaaag ggtgcgccag 39660

tccccattaa cctaaatagg acagacacca ttgcaaaagt tggttagtca atctgttccc 39720

ttttattcag caacatttgt cctaattact acatgacaac aattccataa gtcaacaaat 39780

gaacttggac caagtaaaat gcagatgtct ctctgctaga gagtagatta ggagattgtg 39840

tcatcactca ttcacactag aatatggaac acaggataca gttcacactt tgtcaatcaa 39900

taacaatgca aagtccaatc tgtaattttc tcttcttaac cttctttcat actagacaga 39960

agtcattgaa aacatgcaaa gagttgaaaa tacactagga ctgcattaca gataggattc 40020

agataatgta tatatgctat atataccaca tataatatgt aatgccatac catttatagt 40080

atatgatata tatgctcaaa ccaactacag agtgtacata aacaccccag accctttatc 40140

cccaaatgca cacacctctg agggactgat atcaagagat tcatgatgtg cacaggatac 40200

acctaatgca agcgcaatta gcaggaactt caccatggta gagcctggat tctctccttc 40260

cgaaggagtt cagagaccaa gggcaggtga tggggagacc cagaaccatc tccaccttat 40320

atagtattga ttattggcct gagattggca tggattgcct gtggtaaaat tccagcatat 40380

cctggtggtg gaaacatctg tgatgacaat tctgtttttc tgctactttt gaaataagat 40440

taacttgagt aaagccatga aattgacctt ttagacttct gtggacttgg gctagctgtc 40500

agaaaacaca aatatccatg tccctaaagt ccaagtttct catttggaac actttaaaga 40560

aatgaactta tttgactcag gctattttaa tgatgacaaa ttttccatca atcagaccct 40620

ttgatcacag gttaccatat ggatattaac aattttttat acaattgaat atcaatggac 40680

atatatttct agaacattct agagtgttct agaatgttct acaacattct ggggcattct 40740

tgtaaaaacc tttgtgaaga agtgtactgt tttcctttct gggcaggaat ttgcaattta 40800

gattcatgat tttaaatatt tttataattt gatattttca tcaagatgtg aagattttta 40860

atgatgtaaa attcccattg ttttgtgggt acatttgttg atactatgtc ctggtaatca 40920

gcattgcttt tgctaacatt actttatata ttcaataata tatacacaca cctttgtttc 40980

tgattgctat aagtgtattt tttgacaact gtgtctctaa atcatttatg caatgaaaag 41040

tcagctgcta attttctcat gtttgtgtct gagaaattct caacgttttc tccattgaga 41100

actttgacct gtggatggat ttgcaaatat tcaccgaaat gcatgactca aaactagttg 41160

tcaatgttcc aaggctttaa ataagaaata ttcacccatc ccatgttcag aaaggttctt 41220

gatgtatgtt cttctttttt agtatacccc atacaaatgt gatccttatt atatttttac 41280

atatttttct tgattcattc cttcttctct gtgtttgatt attcaagaga taactcagtt 41340

ccactggaac aagattgggc tgacctacaa acatatttat tttcatccat tcatttcttg 41400

tgaaatctct actttccttc agaattctaa tgtgatttgg aatacagata atgttgggaa 41460

aatgtaatga aaatcaacca gaaaaagctg tcatttaata cttccaaagt ggataattac 41520

ttaagactgt atgtgcactc attaaagtcc ttctcatttc tcctccagac ccagtaacaa 41580

caacacatta atcctattta ttgagtatcc ttctggaaaa ttacctacaa ttttgcacaa 41640

actcaggttc attcttccac atttccaaca gttttattaa aatataagct ttccttcctt 41700

atttattaag tgaagtgagt ttctctccct tctacctgat tacagagaaa ggtgatacaa 41760

cacagcctaa actggagtct tggaaagata aaaacaaatt ctgcctcatg tcaaaacata 41820

catttattcc taaggaactt aaagattatc tctgtctgtt tgaactttaa tattgaagca 41880

tgtacacaaa cacacacaca catgcacaca cacatacata cacacacata cacacatgtt 41940

tcttatgttc ttgtgtattt attcataaat attttatata tggatatggg tttttatata 42000

ttttctatct gtggatatat atttatgtgt aatgtaagta tagctatatt ttacattcag 42060

atttatatat tccaatttat acatgtatga tacatatata catgtgtgat acatacatat 42120

ttgtttccat tttcagtaat ttaccaatta aattcctaat ccacacattt tgtctacctc 42180

agaaaagtga agaaagaatg gaaaatgtag gtgcttcaaa ggacagagtt aaaacataca 42240

aaatactgac acaacggatg ctgttattga agtcatggcc aagcttagaa ctctttgatg 42300

tctgaccttt gagtagaact tggctaaaag tctgtctcct ttcttcttct tttttaattg 42360

gatattttat ttatttacat ttcaaatgtt atcccctttc ctggcttcac ctctggaaaa 42420

cccctatccc atcttcctcc atctctttct gagggtgctc ctacccaccc attcccacct 42480

caccacactg acattccctg acactggagc attgagtcat ttacaactca aatgctatcc 42540

taaatgtccc ttatatcctc cccccaccca gtagccttat ttataatagc cagaacctgg 42600

aaagtgccct gatgtccaag ggcctccctg ccattgatgc caaacaaagc catcctctgc 42660

tacatatgct gctggagcca tggatccctc tatgtgtact ctgtggttgg tggtttagtc 42720

cctgggagct ctggggttac tggttatctc atattgttgt tcctcctatg gggctgttca 42780

tcccttcaac tccttcaagt accttctcta actgctgtat tgtggtcccc atgctcaatc 42840

caatggttgg ctgcaaacgt gtgcctctga atttgtaagg ctctgtcaga gcccctcagg 42900

agacaaccat atcaggctcc tgtaagcaag cacttcttgg catccccaat agggtctggg 42960

tttggtgtct gtatgtgatg gatccccagg tcgggcagtc tatggatggt ctttccttca 43020

gactctgatc cacactttgt tcccatactt cttttagaca ggttcaattc tgggttaaaa 43080

atttggatat gagtgggtga ctacgtcccc caacctgggg tcttgcttaa cttctggata 43140

tggtctctac atgttcatcc tccccttttt tgggcatttc agctaatggc atccaagttg 43200

ggacctggga gcctcttaat ttactggcat ctgggacttc ctgatggcta tccctgtttc 43260

ccatcattca ttgctacaca cctctgttca aattcctgac cctctgtaaa atcgtccctg 43320

tctcctagca cacttgttct tacaccccag tccctctcct tctcctctct tccttccaag 43380

tccctcctat cctctacctt ccaagaatat tttgttctcc cttctaagat ggtctgaagc 43440

atccatactt tagtcttctt cttgagcttc atatggtctg tgaattgtat cttgggtatt 43500

ccgagatttt gggttaatat ccacttacca ttgagtgcat actatatgtt ttcttttgtg 43560

actgggttac ctcaataagg atgatacttt tttgttccat tcatttgcct aagaatttca 43620

tgaagtcttt gtttttaata gctgagtagt tctccattgt gtaaatggac catattttct 43680

ctatttgtct gtagaaggac atcagggcac tttccaggtt ctgcctatta taaataaggc 43740

tacttggtgg ggggaggata taagggactt ttaggatagc atttgagttg taaatgaaga 43800

aaatatctaa taaaaattat tataaataaa taaataaatc tattataaat atagtggagt 43860

atgtgtcctt gttatatgtt ggagcatctt ttgggtgtat gttcaggagt ggtatagcta 43920

gatcctcatg tccaattttg tgaagaacca ccagaccagt tataccacca gattagttat 43980

acctccttat aattccacca acaacagatg agtgttcctc tttctccaca tctttgccag 44040

catctgctgc cacctgagtt cttgatctta gtcattctga ctggtctgta gtggaatctc 44100

agggttgttt tgatttgcat tttcctgata actaaagatg gtgaacattt gtttaggtgc 44160

ttcttgtcca ttcaatattc cttagttgag aattctctct tcatgtctgt actccattta 44220

aaatagggtt atttggtcct ctggagtcta actttagaat tatttgtata tttcggatat 44280

tagcactcta tcgaatgtag gattggtaaa gaacttttcc cagtctgttg gtttctattt 44340

tgtcccattg acagtctcct ttcccttaca aaagctttgt aattttagga ggtctcattt 44400

attgattgtt gtttttagat cataagccat tgctgttctg ctcaggaaat tttcccctgt 44460

gcacatgtgt ttgaggctct tacccacttt ctcttctatt agttgcatta tatatggttc 44520

tatgtggagg tccttggtcc acttggagtt gatctttgta caaggatata agaatggatg 44580

gatttgcatt cttctacata ctgactgcca gttgaaccag caccatttgt tgaaaatgct 44640

gtcttttttc cactggatgg ttttagctca ttgtcaaaga ccaggggaat ataggtgtgt 44700

tggttcactt ctgggtcttc aattctattc tattgatcta cctgccttag tctgtaccaa 44760

taacatgcag tttttatctc tattgctttg tagtacaact tgaggtcagg gatgatgatt 44820

tccactgaag ttcttttatt gttgagaata ttttttgcta tcctgggttt ttgcttattc 44880

caaataaatt tgaaaattgc tctttttaag tctatgaaga agtgtctcct tttcagtagc 44940

ctgctgacat tccctactca agaaacaaca aatgtttatt gttttttcta ttctttgatt 45000

ttgtccccca ttatatttta cacaatgttt gggtttattt gcttccctct ttgttttctt 45060

tcctttctat tgatttaata atctatggat tcttctgtgc attcagtttc gaggaaaaac 45120

agtgaggaaa tgaggcacta gaaattctga ggctttcata gtagtgaggg atggatctgc 45180

taattgtccc atttattggt ggaagatttc tgtcattctc agaatcaggg tttctgtgtt 45240

agaaatttca tggccttggg agaggtgtgg tgactaatgt aaaaactcaa ataaaatttc 45300

agttaaaacg ttaaaaagaa aagaaactat acaaccttgc ctttttcaga tcatagaggg 45360

aaaatgttca actttttctc atttaatatg tttaaggttg aaatagcata tgttaattgt 45420

attaattata catcattata gatttcattg tgataaataa taatcgggtt tatttcaaag 45480

tgcagcccta ttcactgaca cttaaacgat ttttaatatt ttagatttta atgagctaac 45540

aaattagcag tattcttgat caattttcaa acacttaatt ttgattaaca ctctcatatc 45600

ttcttgtgtg ccctccaact ccactcccca acccagctaa accattcact gtccaacact 45660

ggcatttctt tattacatca tgtttacata gtactgatac tcctttatgc tctattttat 45720

tttaagactt ttgaagatat tttattttag ttttgcaaac atatccacac actttcttcc 45780

tcctatatat gcacatatat gttgcaagct aggttttgtc tactggttgg taattttcat 45840

gattagctga tttcttaaaa ttaataatat gaactttatg tatcagttga gataattacc 45900

atgggtattg cccatagtcc tactgctttt gcacctggtt ttgtcatcaa gtggtgtgga 45960

gctgacctca accaaatcag tttagtagaa tttcttcatc tttggaatct taaaataagt 46020

taagaaaaag tatgcttgct tctttttcaa atgattgcta gggttcggta tcaaaataac 46080

ttggtcttaa atctgctttt ggaggaaaat attttattac tgactcaata aatagttaac 46140

tgaaaaatag ttaatgttgt cctgtgtaat tttatcttaa ggtgtctact gctaggatga 46200

aacaccacga ccaaatgcaa cttggggagc aaagggttta tttggcttaa aaatccacat 46260

catagcccat caattaagga agtcaggaca ggaactcaaa cagggcagga atccagaggc 46320

aggcactatt gcaaaggcca tggaggggtg ctgcttactg agtagctcag cctgttttct 46380

tatacaactc aggaccacca gcatgcggtg gctccatgaa caacaggctt tgctctcctt 46440

catttatatc taatctttaa aatgtcctat aagcttgtct acagcctaat cttatggagg 46500

cattttctca attgagatcc tttctctcag atgactttag tttgcgtcaa gtggcataaa 46560

actcaccagc acacttcatt taattcagtc ttagtgaaat gcatgttagt agcaataaat 46620

ccattttctg cagactctcg gacctgtgtc actgaagttt tcttaataaa acaaatttgt 46680

gtcagtttct gtgttgttaa tgtatgttta tctgatttcc tttcttgatt ttattaattt 46740

atttatcttt ccttctctca ggcactttct cttctctccc ttctctttac ctcatcaaac 46800

aatttcttgc tttgatcttt aaatgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgctc 46860

tttggactgt gtttttgtta tgcctgtact gaaaagaggc gtggagctca aacacgtggt 46920

taaaaataac gtggatctca atgtcagtga caggaaaaaa aaacccatat gattccaaaa 46980

accttcagtc ctcatatgtt tcatgcaaca aatttggaaa aagggtgatt tagtgacaga 47040

attcatacca actcttcaag tgagtaactg tccaaaatta gatcttgtca agtgtcaaat 47100

ttaaatattg agtcatcttt gggaaatatt gagaagtgga gtaataaagg ttttaagaaa 47160

ataagagtga acctatctgc atttcaatat gatagctact cacttctggc agagtgagaa 47220

taaattttaa agggtatggc ctttagtagg tcacacacct gtaagtatgt actgtacaca 47280

aatacaactc caagcataat ttaaaatttt tttttaaaaa aatgagaaag tggaggaata 47340

aaaaaacagc tggaaggaat tagcgggaga aatggggatc aatattatca aaattcattt 47400

tgtatatgta tgaaattttc aaacacttaa taagattatt atatgcatta aaataacttt 47460

aagcatgttc agtgtggata agtcaatatg taaatgaggg actgaaaaag taacagaaaa 47520

caaaaattct gcatagaaat acttaatatc tggaaagaac acagatgtcc ctcaacagag 47580

gaatggatac agaaaatgta gtacatttac acaatggagt agtactcagc tattaaaaac 47640

aatgaattta tgaaattctt aggcaaatag atgtatctga aggatatcat cctgagtgag 47700

gtaacccaat cacaaaagaa gtcacttgat atgcactcac tgataagtgg atattagccc 47760

agaaacctag aatacccaag atgcaacttc caaaacacaa gaaaatctag aaggaagacc 47820

aactcatgga tacttcattc ctccctagaa tagggaataa aatatccatg aaaggacttg 47880

cagagacaaa gtttgaagct gagacaaaag gatggaccat ccagagactg ccccacccgg 47940

ggattaatcc cataatcagc caccaaatgc agacactatt gcatatgcca gcaagatttt 48000

gctgaaagga ccctgatata gctgtctcct gtgaggattt gccagtgcct ggcaaataca 48060

gaagtggatg ttcacagtca tttatagcac ggaacacagg gctcccaatg gaggagctac 48120

agaaagtacc caaggagcta aagggatctg caaccctata ggtggaacaa cattatgaac 48180

taaccagtac cccggagctc ttgtgtctag ctgcatatgt agcagaagat ggtctaattg 48240

gccatcactg ggaagagagg ccccttggtc tagcaaactt tatatgcccc agtacagggg 48300

aaagccaggg ccaagaagtg ggagtgagtg ggtagaggag cagggcgggg ggagggtata 48360

ggggactttt gggagagcat ttgaaatgta aatgaagaaa atatctaatt aaaatttttt 48420

taaaagaaag gcttcatata gactctgctc ttctatttac taaatactca aatagcccac 48480

tttacataag ctttatttaa aaccaaaacc agtcatcaaa cacaagatca aacacactct 48540

atccttgtct gtggaaaatg aagattgtca cctgagtttg acatcggaca ttcttcacac 48600

atttgctagg gcatgtgcat gccttcgctc acaggaacat atacacatat gcgcgcacac 48660

aggaattttt ttaaaacaca catttttctg gagaataatt tattcgtttg tttgttattt 48720

ggttggtttt ctggaggcaa gatgtcacta agtagctctg gctgtcctgg cactcactat 48780

gtagaacaga ctagacttga actcacacag atcaacctcc ctctgcttct acagtgccag 48840

gattaaaatg tatgcatccc catgcctgat taagaccatt gtattttcaa aacaaacttc 48900

acattcctgt gggaaatgct cacaagtata gctataaatg cagataaata gagtcattat 48960

ttttctgtat caacattggc tctggaacaa atgtttaaag agctgatcca aaaattagat 49020

ctcaggagga ggagtattgt tattttctaa aatgttcaga tttctgcttt acttttcaac 49080

tgtatgctga agtatctttt tttcacagca ttaaaatacc tttatttgta attagatttt 49140

aaaatactgt caaaaattat gccaggaaac aggaaggaca cagcttaccc tagagggaaa 49200

aacaataaat ccaagacaga tgatttcctc tacaagggtt tttcttggca aacagatata 49260

taagcagaac cagggcactc acagtagata gcaactgcac agacaggttg ggagtttaca 49320

aaaccaaaac ttgcattgtt gaggaaaggg aaatgacaca gaggagcata ttgactggag 49380

aatacccatt gtctgaattt tttttctctc ttttctgttg tgacatttac tacttagtaa 49440

cacagtaagc taaacaacca gtgccatggt aggcttgagt cagctctttc aggttcatgt 49500

ccatcaaaga tctacatctc tcccctggta gcttaagaga agccatggtg gttggtattt 49560

cctactgcca gacagctggt tgttaagtga atattttgaa gtcctaaaaa ttgtgttgaa 49620

ttttatagca ttatccatca ctttgcatta tttacttttt tcaaaaaaat tgacaatctc 49680

atgactgcac ataatatatt ttgatcaatt ccactacatc ctctttaata ggacaatagg 49740

aggtgctgtt tgggttccta tagaggactg atctcacagg aggaagtatg ccactttgag 49800

gaattggatt tgaggtctca atgcaatgct tgtctacttt tctctgttta ccacttttgg 49860

atcaagatgt aatctcttag cttctggatc gagacagtgc catgataaag atggaaactc 49920

atacctccga aacagtgacc ttgaagaaaa acttccttct gtatgttgca ttttctactc 49980

taacaaattt acttttgtag tgctccaatg agtaactgac atatcaatta aaagtggggt 50040

taggggagac atactgactt gaataatttt tgcactatag tgtaggtttt gacaatttct 50100

acagtgtttt atatttcaga actgtgttcc tgagatgtgc gatatctcag ggggtaatga 50160

tgactgagtt ttgtgaccta cttagtagga gaagaaagaa ccagtatcca ccagctatct 50220

tctgacctcc acacacatgc caaggtatgg gcatacccag tcccatgtac aaaataaatg 50280

ataaagtttt aacatgtatt atgcacaaat ccaaaattaa taaggacact tactacgtgt 50340

ataactgaaa cccaaagtaa ttgtaaaatc aagtatttca tatttctctt tcatgtgcag 50400

atggataaca gaagtcaaaa ctgtctttct ggctgtttta atataacata taattctatg 50460

caaaaaatac tgatactatc ttttaaaaag aaaaaaactg tatatgcata cattatttca 50520

tattaaacac tattaagaag aaatgagtgc aaacattgta tttcaaattt cagattaatg 50580

gattctgaca tgtggaaggg ttacatttcc caaatgtctc atcagcacag gttcctgaaa 50640

actggggaaa cccaggacta atgagatgga ttttcacata gaggtggata ctgccaagcc 50700

tgggtacctg agcccacaca cccatgaact caaaataatt tttaaaaaga agaaatttaa 50760

aatttaacta tatatattat gattatccaa taagctttct agatgtttct ttggttatat 50820

gtcataattg tcgtgattga caagctgtta aatttgagtg atgtttgtaa agaaataaca 50880

ataaattata tctatagaag caagacttca tctttaggat caagactgta tgctccatgt 50940

tatcacagct gtttaaccag acaaaggcta gaacctccag ttccacaaac aaatgtgaat 51000

tctactgtgt ccagtttact gccatgtttt tggtcatgtg aacaatgtgg tttgtgccaa 51060

cattagagca gagttcacaa gtgcattttg cctccccagt attgctgatg aatccatggt 51120

tcaggttcaa gggtgttgaa aacttgattg aaaatggtca gacttgatat tcttccagta 51180

tatctgattg gaggaactga taatagatat cagatttaaa cctctaccat tccagttaag 51240

ataatatgat agcatcttgt tcttcatctt cctttttctt aatagggaca taaaaccaat 51300

gaataaaaat atacctgaaa catgggatag gcactgggca ttggaaatga caataaaagt 51360

aaattttcca tccctagtaa agttctccag gaacctattt gtatactaaa tgacacaatg 51420

tcaatgtcag tgcacaactg ccaactggga tgcagaacac tgctcacgcc aaccatcctg 51480

aaagccaact ataaaaagca gagagatact ctgcaccttt tcagtgaggt ccagataccc 51540

acagagcaga gacagtcgct cacacatgga taaagtttta aacagagagg aatctttgca 51600

gctaatggac cttctaggtc ttgaaaggag tgcctggggg aatattcctc tgatgagaaa 51660

ggcatattta aaaaaatgca aggagtttca tcctgataaa ggaggagatg aagaaaaaat 51720

gaagaaaatg aatactctgt acaagaaaat ggaagatgga gtaaaatatg ctcatcaacc 51780

tgactttgga ggcttctggg atgcaactga ggtatttgct tcttccttaa atcctggtgt 51840

tgatgcaatg tactgcaaac aatggcctga gtgtgcaaag aaaatgtctg ctaactgcat 51900

atgcttgctg tgcttactga ggatgaagca tgaaaataga aaattataca ggaaagatcc 51960

acttgtgtgg gttgattgct actgcttcga ttgctttaga atgtggtttg gacttgatct 52020

ttgtgaagga accttacttc tgtggtgtga cataattgga caaactacct acagagattt 52080

aaagctctaa ggtaaatata aaatttttaa gtgtataatg tgttaaacta ctgattctaa 52140

ttgtttgtgt attttagatt ccaacctatg gaactgatga atgggagcag tggtggaatg 52200

cctttaatga ggaaaacctg ttttgctcag aagaaatgcc atctagtgat gatgaggcta 52260

ctgctgactc tcaacattct actcctccaa aaaagaagag aaaggtagaa gaccccaagg 52320

actttccttc agaattgcta agttttttga gtcatgctgt gtttagtaat agaactcttg 52380

cttgctttgc tatttacacc acaaaggaaa aagctgcact gctatacaag aaaattatgg 52440

aaaaatattc tgtaaccttt ataagtaggc ataacagtta taatcataac atactgtttt 52500

ttcttactcc acacaggcat agagtgtctg ctattaataa ctatgctcaa aaattgtgta 52560

cctttagctt tttaatttgt aaaggggtta ataaggaata tttgatgtat agtgccttga 52620

ctagagatcc attttctgtt attgaggaaa gtttgccagg tgggttaaag gagcatgatt 52680

ttaatccaga agaagcagag gaaactaaac aagtgtcctg gaagcttgta acagagtatg 52740

caatggaaac aaaatgtgat gatgtgttgt tattgcttgg gatgtacttg gaatttcagt 52800

acagttttga aatgtgttta aaatgtatta aaaaagaaca gcccagccac tataagtacc 52860

atgaaaagca ttatgcaaat gctgctatat ttgctgacag caaaaaccaa aaaaccatat 52920

gccaacaggc tgttgatact gttttagcta aaaagcgggt tgatagccta caattaacta 52980

gagaacaaat gttaacaaac agatttaatg atcttttgga taggatggat ataatgtttg 53040

gttctacagg ctctgctgac atagaagaat ggatggctgg agttgcttgg ctacactgtt 53100

tgttgcccaa aatggattca gtggtgtatg actttttaaa atgcatggtg tacaacattc 53160

ctaaaaaaag atactggctg tttaaaggac caattgatag tggtaaaact acattagcag 53220

ctgctttgct tgaattatgt ggggggaaag ctttaaatgt taatttgccc ttggacaggc 53280

tgaactttga gctaggagta gctattgacc agtttttagt agtttttgag gatgtaaagg 53340

gcactggagg ggagtccaga gatttgcctt caggtcaggg aattaataac ctggacaatt 53400

taagggatta tttggatggc agtgttaagg taaacttaga aaagaaacac ctaaataaaa 53460

gaactcaaat atttccccct ggaatagtca ccatgaatga gtacagtgtg cctaaaacac 53520

tgcaggccag atttgtaaaa caaatagatt ttaggcccaa agattattta aagcattgcc 53580

tggaacgcag tgagtttttg ttagaaaaga gaataattca aagtggcatt gctttgcttc 53640

ttatgttaat ttggtacaga cctgtggctg agtttgctca aagtattcag agcagaattg 53700

tggagtggaa agagagattg gacaaagagt ttagtttgtc agtgtatcaa aaaatgaagt 53760

ttaatgtggc tatgggaatt ggagttttag attggctaag aaacagtgat gatgatgatg 53820

aagacagcca ggaaaatgct gataaaaatg aagatggtgg ggagaagaac atggaagact 53880

cagggcatga aacaggcatt gattcacagt cccaaggctc atttcaggcc cctcagtcct 53940

cacagtctgt tcatgatcat aatcagccat accacatttg tagaggtttt acttgcttta 54000

aaaaacctcc cacacctccc cctgaacctg aaacagaggg cagaggaagt ctgctaacat 54060

gcggtgacgt cgaggagaat cctggcccca tggaagatgc caaaaacatt aagaagggcc 54120

cagcgccatt ctacccactc gaagacggga ccgccggcga gcagctgcac aaagccatga 54180

agcgctacgc cctggtgccc ggcaccatcg cctttaccga cgcacatatc gaggtggaca 54240

ttacctacgc cgagtacttc gagatgagcg ttcggctggc agaagctatg aagcgctatg 54300

ggctgaatac aaaccatcgg atcgtggtgt gcagcgagaa tagcttgcag ttcttcatgc 54360

ccgtgttggg tgccctgttc atcggtgtgg ctgtggcccc agctaacgac atctacaacg 54420

agcgcgagct gctgaacagc atgggcatca gccagcccac cgtcgtattc gtgagcaaga 54480

aagggctgca aaagatcctc aacgtgcaaa agaagctacc gatcatacaa aagatcatca 54540

tcatggatag caagaccgac taccagggct tccaaagcat gtacaccttc gtgacttccc 54600

atttgccacc cggcttcaac gagtacgact tcgtgcccga gagcttcgac cgggacaaaa 54660

ccatcgccct gatcatgaac agtagtggca gtaccggatt gcccaagggc gtagccctac 54720

cgcaccgcac cgcttgtgtc cgattcagtc atgcccgcga ccccatcttc ggcaaccaga 54780

tcatccccga caccgctatc ctcagcgtgg tgccatttca ccacggcttc ggcatgttca 54840

ccacgctggg ctacttgatc tgcggctttc gggtcgtgct catgtaccgc ttcgaggagg 54900

agctattctt gcgcagcttg caagactata agattcaatc tgccctgctg gtgcccacac 54960

tatttagctt cttcgctaag agcactctca tcgacaagta cgacctaagc aacttgcacg 55020

agatcgccag cggcggggcg ccgctcagca aggaggtagg tgaggccgtg gccaaacgct 55080

tccacctacc aggcatccgc cagggctacg gcctgacaga aacaaccagc gccattctga 55140

tcacccccga aggggacgac aagcctggcg cagtaggcaa ggtggtgccc ttcttcgagg 55200

ctaaggtggt ggacttggac accggtaaga cactgggtgt gaaccagcgc ggcgagctgt 55260

gcgtccgtgg ccccatgatc atgagcggct acgttaacaa ccccgaggct acaaacgctc 55320

tcatcgacaa ggacggctgg ctgcacagcg gcgacatcgc ctactgggac gaggacgagc 55380

acttcttcat cgtggaccgg ctgaagagcc tgatcaaata caagggctac caggtagccc 55440

cagccgaact ggagagcatc ctgctgcaac accccaacat cttcgacgcc ggggtcgccg 55500

gcctgcccga cgacgatgcc ggcgagctgc ccgccgcagt cgtcgtgctg gaacacggta 55560

aaaccatgac cgagaaggag atcgtggact atgtggccag ccaggttaca accgccaaga 55620

agctgcgcgg tggtgttgtg ttcgtggacg aggtgcctaa aggactgacc ggcaagttgg 55680

acgcccgcaa gatccgcgag attctcatta aggccaagaa gggcggcaag atcgccgtgt 55740

aataattcta gagtcggggc ggccggccgc ttcgagcaga catgataaga tacattgatg 55800

agtttggaca aaccacaact agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg 55860

atgctattgc tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt 55920

gcattcattt tatgtttcag gttcaggggg aggtgtggga ggttttttaa agcaagtaaa 55980

acctctacaa atgtggtact cgagataact tcgtataatg tatgctatac gaagttatat 56040

gcatggcctc cgcgccgggt tttggcgcct cccgcgggcg cccccctcct cacggcgagc 56100

gctgccacgt cagacgaagg gcgcagcgag cgtcctgatc cttccgcccg gacgctcagg 56160

acagcggccc gctgctcata agactcggcc ttagaacccc agtatcagca gaaggacatt 56220

ttaggacggg acttgggtga ctctagggca ctggttttct ttccagagag cggaacaggc 56280

gaggaaaagt agtcccttct cggcgattct gcggagggat ctccgtgggg cggtgaacgc 56340

cgatgattat ataaggacgc gccgggtgtg gcacagctag ttccgtcgca gccgggattt 56400

gggtcgcggt tcttgtttgt ggatcgctgt gatcgtcact tggtgagtag cgggctgctg 56460

ggctggccgg ggctttcgtg gccgccgggc cgctcggtgg gacggaagcg tgtggagaga 56520

ccgccaaggg ctgtagtctg ggtccgcgag caaggttgcc ctgaactggg ggttgggggg 56580

agcgcagcaa aatggcggct gttcccgagt cttgaatgga agacgcttgt gaggcgggct 56640

gtgaggtcgt tgaaacaagg tggggggcat ggtgggcggc aagaacccaa ggtcttgagg 56700

ccttcgctaa tgcgggaaag ctcttattcg ggtgagatgg gctggggcac catctgggga 56760

ccctgacgtg aagtttgtca ctgactggag aactcggttt gtcgtctgtt gcgggggcgg 56820

cagttatggc ggtgccgttg ggcagtgcac ccgtaccttt gggagcgcgc gccctcgtcg 56880

tgtcgtgacg tcacccgttc tgttggctta taatgcaggg tggggccacc tgccggtagg 56940

tgtgcggtag gcttttctcc gtcgcaggac gcagggttcg ggcctagggt aggctctcct 57000

gaatcgacag gcgccggacc tctggtgagg ggagggataa gtgaggcgtc agtttctttg 57060

gtcggtttta tgtacctatc ttcttaagta gctgaagctc cggttttgaa ctatgcgctc 57120

ggggttggcg agtgtgtttt gtgaagtttt ttaggcacct tttgaaatgt aatcatttgg 57180

gtcaatatgt aattttcagt gttagactag taaattgtcc gctaaattct ggccgttttt 57240

ggcttttttg ttagacgtgt tgacaattaa tcatcggcat agtatatcgg catagtataa 57300

tacgacaagg tgaggaacta aaccatggga tcggccattg aacaagatgg attgcacgca 57360

ggttctccgg ccgcttgggt ggagaggcta ttcggctatg actgggcaca acagacaatc 57420

ggctgctctg atgccgccgt gttccggctg tcagcgcagg ggcgcccggt tctttttgtc 57480

aagaccgacc tgtccggtgc cctgaatgaa ctgcaggacg aggcagcgcg gctatcgtgg 57540

ctggccacga cgggcgttcc ttgcgcagct gtgctcgacg ttgtcactga agcgggaagg 57600

gactggctgc tattgggcga agtgccgggg caggatctcc tgtcatctca ccttgctcct 57660

gccgagaaag tatccatcat ggctgatgca atgcggcggc tgcatacgct tgatccggct 57720

acctgcccat tcgaccacca agcgaaacat cgcatcgagc gagcacgtac tcggatggaa 57780

gccggtcttg tcgatcagga tgatctggac gaagagcatc aggggctcgc gccagccgaa 57840

ctgttcgcca ggctcaaggc gcgcatgccc gacggcgatg atctcgtcgt gacccatggc 57900

gatgcctgct tgccgaatat catggtggaa aatggccgct tttctggatt catcgactgt 57960

ggccggctgg gtgtggcgga ccgctatcag gacatagcgt tggctacccg tgatattgct 58020

gaagagcttg gcggcgaatg ggctgaccgc ttcctcgtgc tttacggtat cgccgctccc 58080

gattcgcagc gcatcgcctt ctatcgcctt cttgacgagt tcttctgagg ggatccgctg 58140

taagtctgca gaaattgatg atctattaaa caataaagat gtccactaaa atggaagttt 58200

ttcctgtcat actttgttaa gaagggtgag aacagagtac ctacattttg aatggaagga 58260

ttggagctac gggggtgggg gtggggtggg attagataaa tgcctgctct ttactgaagg 58320

ctctttacta ttgctttatg ataatgtttc atagttggat atcataattt aaacaagcaa 58380

aaccaaatta agggccagct cattcctccc actcatgatc tatagatcta tagatctctc 58440

gtgggatcat tgtttttctc ttgattccca ctttgtggtt ctaagtactg tggtttccaa 58500

atgtgtcagt ttcatagcct gaagaacgag atcagcagcc tctgttccac atacacttca 58560

ttctcagtat tgttttgcca agttctaatt ccatcagacc tcgacctgca gcccctagat 58620

aacttcgtat aatgtatgct atacgaagtt atgctagcta gtgactcaac aagatcagga 58680

ttaggtgagt caaagcacat taattttata tcttgaagtt ttaattttaa ttttatttta 58740

atatttaagt tattaatatt taatatttaa agtaaataat attttatttg ttctttatcc 58800

ttttcatata tttatataat gtatatttat ctttcatact tccacacacc tcatccaagc 58860

aacacatctc cctctatact tcatggcttt taaattttat tattatttat tattattatt 58920

acctcaatga atccaattgg tgctatttct gaatagggta tgtcaattcc tggaggcatg 58980

agtaatgtaa tataccaggg ctattatgta atataaaaaa atggactgca gggagctggt 59040

ggcacatgca tttaacctag cgctcaagag gcagaagcaa gcatatgtct gcgttttaga 59100

taaccctagt ctacagagtg agttccagga cagcaagggc tactcagaga aaccctgtct 59160

cataaaacca aaaagtatat tttttaaagg cagaagagga aaggagggag ggagggaggg 59220

aaagaggcag acagacagac aggcaggcag gcaggcaaaa agaaggaaaa agaaaaatat 59280

ggaccctccc tctcccagaa actatcaact ggcaatagct ctttggtggg gggggggggt 59340

cctgaatccc tctctgctca attctagaat gttaattagc ttgatctgac cagggtcttg 59400

tgcagaacac cacagttgct gtgagttcat gattgtaaca gatctgtcat gttcagaaaa 59460

cagaatttta tggctctact ccccatccag atgataattg atggctaagc atccacagtc 59520

acttgtcctc atcctttgac cagctacaaa tttctgcaca aaccactccc cactgtaaaa 59580

agttgagcag aagtcaaaca tggaggcaca cacccttaat cccaacactt gggaggcacg 59640

ggtagatgaa tctctgtgag tatcaagcca gcctgatcta catactgagc tccagaagat 59700

ccaggtacat agtctctatc taaacaaaca aacacaaagt taaaaagttg atttgaccaa 59760

aattgagaga agcataaatc tatgagtatt tttaagaccg tggcttggaa acatgacagt 59820

tcatcaccac tggtctcctt cataggctcc atgagctcca ttgtcacagg cttttgactc 59880

gaattacaat agaaacccac ccttacccct gttcttccat agatatgaag ttccttccat 59940

ggagctggca tgaaatttaa tcagagagtg cttggctccc caatacagcc tttattgcac 60000

cagtggacgc aaggatgatt ttatagtgtg ttggggaagc atggtgacat cactgacatc 60060

ttatcccaca tacacagcct attaagtaca tctaagcact gtgaacgagt ttcctagtcc 60120

atttgacatc gatttcttga tgccctacag ccacagcatt tggtgtcttc agcaatagtg 60180

ccctaccatt tagatatggt gtatagtcaa gagatatggc aatagccaag ttattttggt 60240

tattccaagg cttccttcca ttaataaata tcatggtggt acccccatga ctaaaaatta 60300

gattttcact gaataaacca tgtcttctgg gaacagcatt ataccattgc agggatcctc 60360

tgctgaaact tttttaatac tatattttta cttagcttac aaactagtgg atttctgtaa 60420

gacttcattt accttcagtt tcagttgacc ctcccctacc ctgttcttcc ctatgcccaa 60480

acacatccac acctactcct ctagcccaca gctctcactt tctaatcttc cctgtcacca 60540

gtgcccaatt atatcgcctg tattattata ttttaatcac acaaccatag gtttccatat 60600

gaggttttaa taacccttca ttctggttaa accttccacc acaccctgat ttccccattc 60660

cacaaccaac tccatgatta agccttcctg ccccaagtat tcttctttat acttcatttt 60720

aatggcatta catttgatgg acccacttcc ttgatggacc caattcaaac cagtttctaa 60780

ttacctggat tccttacata ctccatatta tgcatacaaa ataaaagatt caagtctaat 60840

gtccacatgt gagatagaat gtgcagtttg tctttctgag cctgagtggc ctcattaagt 60900

ataataattt ccagttcctt ctatttactt ggaaatttca tattttcatt gttctctatg 60960

gctgagtaat attccatctt atacattaca ttttccttat ccattcatta gttgatgaac 61020

agttgggtca acttcgtttc ttagctatta tgaacttaac ctcagtgagc atggacattc 61080

aaaggtctct gtaacagaat ataaacccct ttgtgtacat atctagaaat ggaggaacta 61140

gagaaagcac ccaaggaact aaagggaact gcaaccctat aggtggaaca acaatatgaa 61200

ctaagcagta ccccggagct cttgtctcta gctgcatatc tatcaaaaga tggcctagtc 61260

ggccatcact gcaaagagag gcccattgga cttgcaaact ttatatgccc cagtacaggg 61320

gaatgccagg gccaaaaagg ggggatgggt gggtagggga gtgggggggg gttggggact 61380

ttttgtatag cattggaaat gtaaatgagc taaataccta ataaaaaatg gaaaaaaaaa 61440

gaaatggtgt aactgagtca catgggaagt ctttttctaa tctttggatt tgtttatttg 61500

atgttcatag tttttgggtt ttggttggtt ttgttctaag ttctttgtat attgtagaca 61560

ctaatcctcc atcacatgtg tagttggcaa agatctccat tccccgagat acctgtgcat 61620

ttaattgaca gcttcctttg ccgtagtttt taattccatg atatctgaca agtgtttgtc 61680

ttactttctt gctacaagaa tcctattcaa agaatccata cctgtgtcta tggttaacac 61740

acactccatg ctttcttctc tatcagcttc aggttaccat gtcttatgac acggtctttg 61800

aatcatttgg agttgaggtt tttttcaagg tgacagggaa gagcccaggt tcatttctct 61860

gtatcctgat gtccactttt tcctattcgg tctatttatg gaattatata tttttatgtt 61920

aggtcatttt tcagtggagg cattaacaat atccagaagg ggactatttc ttactagtgt 61980

tgagatggta ttctcctata tggggctggt actgaaggca gcaagttcta cccctagtct 62040

tcctgtgaga ttcaactact atctgggacc tcgagtgaga ctctgtctgt aggatacatg 62100

gggcttggta aactccaatg tgaaacaaaa aatatataat tttagtttag attcatagaa 62160

actacatcct caaataaaca cataagttct aaaaagtacc aatttaggtc ttgatataag 62220

atcatttgtc atataaaaat tttccatata aggaaaattt ccatacaaag ttcatgtata 62280

tttccaaata tacaaaattc tgtaaaatgt ttttgcatga tacatcttgt cattgtttgc 62340

ctctttaatg gcttgtattt gtttcatttt ctactctcat caaatatcat gtattactat 62400

cctaaatata tgaaataatt ctgttccagc attacagatg acatcaggaa ttttccagta 62460

tatttttcct ggaacctgaa acatcaatat gaagatgaag caatcttgtc tctcagatca 62520

tattttccta tttattgcaa attacaattc ctgtctctgt actttctctt tcactcattg 62580

tttcccatgt tctaatcggt attagtgcat ctttgaatgt ttaaataaat ttattttact 62640

tgcatacgtg ttgttaaaag gggaagctaa agtacaatgc acataaatac ctatttgact 62700

ttttttaaag gagaggaggg ttggaggggt ggcatgtgat tgctcacgcc tgtaatttca 62760

gcaccgggga aagaggtaga gacagttgaa tcctctgatg tcaccagtag ccagcctaga 62820

ctacatgaaa tattgcaggc cagtgagaga tcatcccaga aaacaaggca gggacatgac 62880

aggcagctca gtggtcaaga gcactagctg ctcttccaca ggacctgggt tatattccta 62940

acactcacat gacaactcac aactttctgt aattccagtt cccagggatt tgacatatat 63000

atggacaacc atgcaagcaa aacaccaatg cacataaaat tttaaaaaac taattcaatt 63060

aaggcagatg tgaatgaagg atgccacctg acataatcct gtggcactca acatttacat 63120

gcacacactt gtgtccatga acacaagtgc aaaaatacag agagagagag agagagagag 63180

agagagagag agagagagag agagagaaca tacaccaaag agtctcatca ttcctacatg 63240

ttacaaactc caatattgta attttgactt tagaaaggaa ggtaaaatat tatattggtt 63300

gtttaaagta aacatttaaa aactttgtag cagaaaatgg cctagttggc catcattggt 63360

aggagaggcc ctttgtcttg caaagattat atgccccagt acaggggaat gccagggcca 63420

ataagcagaa gtgggtgggt tgggaagcag ggtggggaag tgtataggga actttcagga 63480

tagcatttga aatgtaaatg aacaaaatat ctaataaaaa aaaagctttg tgtgctagta 63540

gtttgtcaac ctgacacagg ccatagtcat ttgggaaagg agacactcaa gaaaatacct 63600

ccaccaggtt caactgtgga gcatttcttg actggtagtc aatgtgaggg caggtcctac 63660

tcactgtgga aaacactgcc aagcaaacca tgaggaacca gacagtaagc agaactcttc 63720

catagcctct gtatcagttt ctgcctccaa gtctctgcct tgacttcccc aaggtgataa 63780

gctacaagtg gtcagatgaa ataaaccctt ttctccctaa gatgcttttg gccatggagt 63840

tcacaaaagc aatagaaacc ctaagacaca gagtaatgtt gaagagctta gatcacaaat 63900

catatcttaa agttgaaaga aaccacccca cacacttgta tgcatatata caaattcaca 63960

tgtggacaaa catacatata tactcaaacc atacatgtat gtatatttaa aaatttgaaa 64020

tgtcacagga agaattattt tgtagtcttt gaactacttt gatttattta ctttaaccac 64080

ttgcctgcta ttgttgggtt caatggtcat gctttcataa tgccttctaa atattaattt 64140

gcatctctgg accaggatca tgctcaactt ttgtcagaga agcttgtttt tgtggtgaga 64200

tgaatgttat gacactgaag tttttgcatc acgttctgac atatgtctat ccacctacca 64260

tttgatcacc cactacgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 64320

gtgtgtgtga tttgaatgag aacagccccc gtaggctcat agatttgatt gcttgatcac 64380

taaggagtag cactatttga aaggataagg agatgtggac ttggaggaag tgagtcactg 64440

aggatgagct ttgtggtttc aagagcccaa gccagaccct gcttcctcat cctacttgct 64500

atggactcag atgtaaaaat ctccactcct tcagcaccat gtctgcctgt gtgctaccat 64560

gccaaaaaat ggaataaatc tctgacactg tgtgaccctc cctgccccga gaattgttga 64620

cctatattgg tccatgagga gcagagacaa tggggaaaga gcaggggctt agaaaccctg 64680

tatgtatggt aataacgata cacagggacc agcttcagag agacaggtca agtttacttg 64740

tggtgattca agggtgatat agttgtctta gttagggttt ctattgctgt ggggagaaac 64800

catggccaaa aacacaaatg aggaggaaaa ggtttattgg gcttacactt ccacagcact 64860

aattatcatt gaagaaagtc aaggcagaaa ctcaaaccag acaagaaccc agaggcaata 64920

gctgatgcag aaaccatgga agggtaatgc ttacatatta ctcatggctt attcagcttg 64980

cattagcttt ttattattat taatcattcc attagtttac atctcaaatg atatctcact 65040

ttcaggttaa cccctccacc aatccccatg aataataacc caattcctgg atacccctcc 65100

attgaccccc atcccacatc caccctccac cttccccttt gcttgtatga gatttctccc 65160

ccatccactc acattctctg aacccactgc tccagcatcc acctacactg gtgcatcacc 65220

cctcccattg ctgtcaggca aggccatcct ctgctacata tgtatctgga gccatggatc 65280

catccaggca cactccttgg ttggttgtct agattctgga aaaactaggt gatcaggcca 65340

gcctaagttg ttattccatt ggggtagcaa ttcccttctg ttcctccagt tcttctgcca 65400

gctcccccac caggttccct gagctcagtc tgatggttgg ctctaagcat ccacatctgc 65460

attggtcagt tgctagccag acttcccaag gaactgccac accaggttcc tgtcagcaag 65520

cacctcttga ccatggcaac agtgttaggt ttggtgtctg cagacagggt ggatctccag 65580

gtggagcttt ccccaaatgg cacttccttc agtctctgtt caattttttg tccctgttct 65640

tcttttggat aggaacattt atgggttgaa aatttgagat gggtgggtag cttcatccct 65700

tgacctggag ctgtgcctat ctattggagg tggtctcttc aggttctgtc tcccccttct 65760

ctgtgcattt ctgctaatgt catctccttt gggtcctggt agcctcatgt ttccctggtg 65820

tctgtgaccc tccagtgact gtccccagtt cctcatttct tactgctaca tattttttgt 65880

tcgatatctt gaccttctgt atctctttga catctcctcc agttcctgat acttccctcc 65940

ttatttcctc accctcctct ctccctccca ggtcttcctc taatagaaca aaaaatgggg 66000

aagagactca aatacttggg cacagaagaa aactccctga agataacacc aatgtgttat 66060

gctttaagat caattgacaa atgggacctc agaaaatgaa aaagcttctg taaggcaaag 66120

gacactgtca ataggacaaa acagtcaccc acagattggg aaaaaatctt taccaaccct 66180

acatctgata gagggctaat atccaatata tacaaagaac ttaggagtta aactccagag 66240

aatcaaataa ctctactaaa aaatgagata aacagagaat tcatgactaa agaaacttga 66300

gtggccaaga agctcctaaa gaaatgttca ccatttgtag tcatcaggta aatgcaaatg 66360

aaaacaaccc tgagttccta ccccacacca gtcagaatgg ctaagatcaa aaactcaaat 66420

gacagcagat gctggtgagg atgtggaata agatgaacac tcctccattg atggtggggt 66480

tgcaagctgg tacaaccact ctggaaatca gactggtggt ttctcagaaa attggacata 66540

gtactacctg aggacctagc tataccactc caggaagtat acccagaaaa tgctccaaca 66600

tgtaataaag acacatgctc cactatgttc atagcagtca tatttataat agccagaagc 66660

tggaaacaac ctagatgtcc ctcaacagag gaatagatac agaaaatgtg atatatttac 66720

acaatggagt actatgcata gatttaaaac aatgacttca tggaattcac aggcaaatgg 66780

atagaactag aaaatatcat tctgagtgag gtaatcaaga cacaagggaa cacacatggt 66840

atgtactcac taataagtgg atattaacgc aaaagctcac aattgccata atacaatcca 66900

tagaccatat ggagcataga aagaaagacc aggatgtgga tgcttcagtc ttgcattgag 66960

gggggatcag cttgcattct taagaaaccc aagactatca gcccaagggt aacaccactc 67020

agaatgggct ggtccctcac ccatcaatca ctaattaaaa aattgcccta caggcctatt 67080

gaggcacttt catttttttc tttttttatt agatattttc ttcatttaca tttcaaatgc 67140

tatccactat accctccccc caaccctgct ccccaaccta cccactcctg cttcctggtc 67200

ctggcattcc cctgtactgg ggcatatgat ccccgcaaga ccaagggttg aggcactttc 67260

ttaattgggc ttcctttctc tcatatgact accacttgtg tcaagatgac ataaaactat 67320

gcaacacaga cagtatatac atatgtatta tctatcatct agaaattcat catctatgca 67380

ttcatcatat atctatccat catctatcaa tacatcattt gtttatccat catttatcta 67440

tgtatcatct attgtcgctc tgttcaccct ctacccatct atctattaaa aaattaactt 67500

gatcagggcc atagtgacac aaacttttaa tcccagaatt tgggaggcag aatacggcta 67560

gcctgatcta catacagagt aagctccagg atagccagag ctacacagga aaaggttgtc 67620

tcaaaacaac aaaaaataaa ttaatgtgta taatgatcaa ggaagacact taacataaat 67680

ttcatcatct atgggaatcc atgaacctgc acacataaaa acgtatgttt actgaatata 67740

catacacctg gagtatttaa tttctgaagt acactagtga aatgtcccat ctatccacac 67800

aactctaggg atctgggtta aattcctggg acacaagtaa atgagggagg ggggagaaca 67860

gagtctccaa aagtgtcccc tgaagtccat acatgtgctg gctatggtgt atacacccac 67920

tcctagacat gcacaataat aaataacttt cctaaataca gaagaatcta attacctcaa 67980

aaagagatct ttattacaga tttgttcaaa tgctagacta taaaagttta ctcagatagc 68040

atgtaacttt ttgatatcct gttgttcttt tctcaacata ccagagatga acataaaaaa 68100

gaggtatgtt ttcctctttt ttgaatatat atttaattgg ttgtattgat gacacaagat 68160

tccaatacac ctgatcatgt atgacatatt agtttctttt ggccaactac ttggcataaa 68220

cagtttgaga aaggaagtgc tgattcactc atgatttaag atagtgtaca gcccatcata 68280

gtgggacaga aactggggca tgtaggccta ctctgtgaca caccattaag aaatatcact 68340

gactgtccct actgcaaaag ccattactcc tccatagtgc ctcagttagg agtagaccta 68400

taagtgacat ccataactat gcatatatat taatcatctc tttattgatt atttcatcta 68460

tgcatgcatc caaccatgca tctatctatc tatctaatct attacctatc tatctatcaa 68520

tctatcaatc tacccatcat ctattatcaa ttgatctatc ttatagtgat atatcatttc 68580

attctctata atctacccac ttataatcta tcacatattc ttccatcatc tatatcaatc 68640

catcatctgt ctatcatcta atcagtcttt ttttcacctg tcatctacca atatgtttcc 68700

tttactacta tcatgttcta tattgtgaca cagcctcact aagaagccca gaaacttact 68760

ttacaacact agctggactt gagttccatg atcccacatt ctcagactta caagtatatg 68820

tgattacata gataaataga taggtttata ggtaggtagg taggtaggta ggtaggtagg 68880

taggtaggta gatagataga tagatagata gatagataga tagatagata gatagataga 68940

taaatagaaa gaaatatatg tgatagattc ataattgata gatgattgat agatcaattg 69000

agagacagat aagtacatat ataagaagat agatggatag agagatatca atacagaatg 69060

tatagataga aatagataca tatagatgat atagatagat taattagatt gataaacaca 69120

gaatatacat agatgcttat atagatggta gtagatgtat agataacagg tggagagtta 69180

gatgatagat tttatgttag acaagcatat gatatctata aacatatgtg tctatgttat 69240

gtagataggt aatagattaa tgatacacaa ataaatggtt gatatatgga tgagtgaatg 69300

gatagatata tccataagta tatttcagta tatattaaac tgaaatattt ctattgatat 69360

atgaacatat atacttttta taagtatact aatatgtttg taaatattta gatatctgat 69420

gtatatacat gtctatctta tatatagatg tcatcttcct atctatacct catatatcaa 69480

taatctgtca tctacctatg ttataactca ttaacccagt taatcataca caaattcaac 69540

taaaataaat tcttcctctt tttattggat attttattta tttacatttc aaaagttatc 69600

cctcttcctg gttttgcctc tgaaaacccc tatcccatct gccctccccc tgcatctatg 69660

agggtactcc ccaacccacc caccctccca ctcccacctc accaccttgg cattctccta 69720

cactggtgca cctagccttc acaggaccaa gggcctctcc tcccatgatg ccagataagg 69780

ccatcctctc ctacatatgc agctggagcc ttgcaaaccc cttcaattcc ttcagtcctt 69840

tccctaattc ctccattggg gtccctgtgc tcagtctaat caatgattgg ctgctagaat 69900

ccatatctgt atttgtcaga ctctgtcaga gcctctcagg agacagccat accagggtcc 69960

tgtgagcaag cacttcttgg cataggctgg gtttggtgtc tatatatggg atggataccc 70020

atctctagat ggtctttact tcagcctctg ctccacactt tgtccccata ttccctttag 70080

acaggagaaa ttctgggtta aaattttaga gataagtggg tggccatatc ccccaactag 70140

gggccttgcc tatcctctgg ttatggcctc tacaggtcct ccctccactt tgttgggcat 70200

tttagctact catctccact gggtcctggg agtctcttgc tttcctggca tctgagacat 70260

taaggtagct attcccagtt cgccatcccc cattgctaga cacctctctt caatttcctg 70320

accctctgtg tatcataccc atctccttcc atacctgatc ctgtccccct ttattgtgtc 70380

tcctttctct cttcctccta agtcctttgc accctctacc tcctgtattt tgttccccat 70440

tctaaagagg actaaagtat ccacacttgc tcttccttct tcttgagcct catatggtct 70500

gtgagttgta gcatgggtat tctgagcttt ttacctaata tccacctatc agtgagtaca 70560

tatcatgtga ccatgtatgt tcttttgtga ctgagttacc tcactcagga tgatattttc 70620

tacttccatc catttactta cgaatttcat aaagtcgttg ttttaatagc tgagtagtac 70680

tccattgtgt aaatgtccca cattttctgt atccattcct ttgttgaagg gcatctgggt 70740

tatttccagc ttctggctgt tataaatatg tctgctatga acatagtgaa gcacgtgtcc 70800

atataatatg ttggagcatc ttttgggtat atgcacagga gtggtatagc tgggtcagca 70860

ggtagcacta tctccagttt tctgaggaat agccagactg atttccagag tagttgtacc 70920

agtttgtaat tccaccagcg ttgggagagt attcctcttt atccatatcc acaccagcat 70980

ctgctgtgac ctgaggtttt gttcttagcc attctgcctg gtgtgaggtg gaatctcaag 71040

gtcattttga tttgcatttc ccagatgatt aatgatgttc aatatttctt aaggtgtttc 71100

ttggccattc gagactactc agttgataat tttctcttta tctcactacc caattttaat 71160

agggttattt gattctcagg actctaactt cttgaatctt tgtatatatt ggatattatt 71220

cctctattgg atgtaggatt ggtaaagatc tttcccaatc tgttggttgc cattttgacc 71280

tattgacagt gccctttacc ttatgctttg caattttatg aggagtgtaa aatattatgg 71340

agtgtaaaaa tgtgaattaa aaataaaatt taaaaaagtc taaatttttt agtctctttc 71400

tctatttctt ccctgcccat gttatcattg agtagagagt tgttcagctt ccattcctat 71460

gtgagctttc tgttgatttt gttgttattg aagaccagcc ttagtcggtg gtgatctgat 71520

aggatgcata ggattatttc aatcttcttg tatctattga cacctgtttt gtgacctatt 71580

atgtggtcaa ttttggggaa ggtactatga ggtgctgaga agaaggtata ttcttttgtt 71640

ttaggatgaa atgttctata gatatctgtt aaatccattt ggttcataac ttctgttagt 71700

ttcactatgt ctctgtttgg tttctgtttt catgatctgt caattgctaa aagtggggtg 71760

ttgaagtctc ccagtattat tgtgtgagtt tcaatgtgtg ctttgagctt tagcaaagtt 71820

tcttttatga atgtgggtgc ccttgcattt ggaacataga tgttcagaat tgagggttca 71880

ttttggtaga ttttttcctt tgatgtgtat gaatgttatc ttttttgata actcttggtt 71940

gaaagtcgat tttatttgct attagcttgt ttctttggac cattttcttg gaaaattgtt 72000

ttccagcctt ttactctgag atagtgtttg tctttgtcac tgaagtgcat ttccagtata 72060

ctgcaaaatg ctgggtcttg tttacatatc cagtctgtta gtctatgtct tgttattgga 72120

gaaatgagcc aattgatgtt aagagatatt aaggaagagt ggctgttgct tattgttgtt 72180

tttcttgttg gaggtggaat tatgtttgtg tgtctatctt cttttgggtt tgttgaaaga 72240

agattacttt cttgcttttc ctagttataa tttccctaca tgtgttggtg ttttccacaa 72300

attatccttt gtaggactga acttgtggaa agatgttgtg taaatttggt tttgtcatgg 72360

aatacttggg tttctccatc taccgtaatt gagagttttg ctgggtatag tagcctgggc 72420

tggcatttgc attctctttg ggtctgtata acatctgtcc atgatcttct gactttcata 72480

gtatctggtg agaagtctgg tgtaattctg ataggtctgt ttttatatgt tacttgacct 72540

ttttgcctta ctgcttttaa tattctttct ttgttttgtg catttggtgt tttgactata 72600

atgtaagaga aggaatttct tttctggtcc agtctatttg gagttctgtg gtcttcttgt 72660

atgttcatgg acatctcttt ctttaggata gggaagtttc cttgtataat tttgttgaag 72720

atatttactg gcacatttag ttaggaatct tcagtctctt ctatacctat tatccttagg 72780

tgtggtcttc tctttgtgtc ctggatttcc tggatgtttt ggattaggag ctttttacat 72840

tttgcatttt gcattttctt tgactgttgc ataaatgttt tctatgctat cttctgcccc 72900

tgagattcta tctcttgtat tttcttggtg atgcttgcat ctatgactcc tgatttattt 72960

cctaggtttt ctatctccag agttgtctcc ctttgtgatt tctttattgt ttctatttcc 73020

atttttagat cctgggtggt tttgttcaat cccttcacct ctttggttat gttttcctgc 73080

aattctttaa gggatttttg tgtttcttct taaagggctt ttacctgatt acctctgttc 73140

tcctgtattt ctttaagtga gttatttatg tccttcttaa agtcctctat catcatcctg 73200

agatgtgatt ttaaatcata atcttgcttt tctgatgtgt tggggtatcc agggtttctg 73260

atgactccaa gtagccttgg tttctgttgc ttatgttctt atgcttacct cttgccatct 73320

ggttgtctct ggtgttagct gaacttgttc tctctgaatg gatcttatcc ctcctatgag 73380

cttgtgagcc tgtgatctta ggtctatcag cactcctcag agaccagttc tttctgggtg 73440

gggtttgggt aaggagaact gtagcacagg gttatctcag gggcacagat ggaaaccaga 73500

agctaagttc ttcctcttat atctgcgcct caacataccc acatcacctt gaacctttcc 73560

taaatatacc atcatgattt atcccattcc agtagttgct ttacactata tatttatttc 73620

aattttatcc tggagctatg tatagcaata aagtcaattt ggcaagagag ttcactgaca 73680

tcttttattt aaaatgtgca tagaaccctc taaaattggc tgcttaatat ggtttttgat 73740

ttggtttgat tttgattttt tttttttttt ttttggagac agggtttctc tgtgtagccc 73800

tggccttcct gaaccaggct gggcttggac tcagaaatct gcctgcctct gcctctgttg 73860

gaattaaatg tatgtgctac gaccacctgg caagataata tgtatttaac tcagtctgaa 73920

acttcttata atctactgtt cctgtattac ctggaaccaa cctccctagg caccattgac 73980

catgtgttgt gaggattaat tcttcactaa acattaattt agtatcacaa gtatgtttta 74040

catttttttc taaaagtgtc aaatcacttt acaccacttt ccaaactgct tcataattta 74100

gtttgttttt atttaattct gtgcacactt gcaaacaaaa gctttcaagg atttcgtcag 74160

agttgaaaaa tctgtatttg tagattttta tttgcatttt tgcaaaactg cataaattaa 74220

tatttgcatt ttatgactac aagcgagcct gataaatttt gctactaaca cacattctga 74280

tatgtttctg tgttaagtaa atgttttaat tctcaaatct taatctcata catctggaag 74340

aggaggtgaa gaggatctca aagaagttgt ggaggggaac cataatcaga ttatattgca 74400

tgaaaaagag tatattttca attaaaaaaa tgtaaagctc atctatctgc cataaaagtc 74460

aattcgctta taaaataaca tttttaaatt ttttatttga tattttcttt atttacattt 74520

aaatgttatc ccctttccca gtttctcctc tgaaaacccc ctatctcttt ccccctcccc 74580

ctgctcccca acccaccgac tcctgcttcc tagccctgac attctgctat actggggcat 74640

agaaccttca caagaccatt gatgaccaac taggacatcc tctactacat atgcaactag 74700

agccacaagt cccaccatgt gttttctttg attggtggtt tagtacctgg gagctctgag 74760

ggtatgaatt ggttcatatt gttcttccta ggaggctaca aaccccttca gctctttggg 74820

tcctttctct agctccttca ttcggggccc tgtgttcagt ccaatggatg actgtaagca 74880

tctgcttctg tatttgtcag gcactggcag accctctcag gagacagcta tatcatgctc 74940

ttgtcatcaa gctcttgttg gcatccataa cagtgtccgg gtttggtggt tgtttatggg 75000

atggatcctc aggtggggca gactctggat ggtcattcct tcagtctctg ctccgaattt 75060

tgtctctgta cctccttcca tgggtatttt gttccccctt ctaagaatga tcgaagtatc 75120

cacactctgg tcttccttct tcttgagttt catatgcttt gagaaatgaa tcttaggtat 75180

tctgagcttc taggctaata tccacttatc agtgagtaca tattgtgtga gttcctttgt 75240

gattgtgtta cctcactcag gatgatgccc tccaggtcca tccgtttgcc taagaatttc 75300

atgaattcat tgtttttaat tgcagagtag tactccattg tgtaaatgta ccacattttc 75360

tgtatccatt cctctgttga gggacatata ggttctttcc agctcctagc tattataaat 75420

aatactgcta tgaacgtagt ggaacatgtg tccttattac atgttggtgc atcttctggg 75480

tatatgccca ggagtggtat ttctggaccc tccgctagta ctatgtccaa ttttctgagt 75540

aaccgtcaaa tggatttcca gagtggttgt accagcttgc aatcccacgg atactgtcaa 75600

taagacaaaa aggcaaccag cagattggga aactatcttt atcaatccta catcagaaag 75660

aggggacata tccaatatat acaaagaact ccagacatcc acataaccct atttaaaaat 75720

ggggtacaga gcttaacaaa gaattctcaa ctgaggaata ccgaatggct gagaagcaac 75780

taaaaaatgt tcaatatcct taatcatcag ggaagtgcaa atcaaaacaa ccctgagatt 75840

ccaatacctc acaccagtca gaatggctaa gatcaaaaac tcagttgaca tcagatgatg 75900

gcaaggatgt ggaaaagaat aaaatgacaa tattaactgt gtctgtttta caagagtttc 75960

tctataatgg cactttcttt ccacagctca atgagaattt gatatattga tttttaatgt 76020

gtattatcat gtacagttgg catatgtgct gatatgtggt gtgacagaaa atacagtgaa 76080

aaatattcac aggcctacta ttttgaaaat tctggtttta tgtgcataat ttggaataga 76140

ttctcagacc ccttctgtgg ggaaatattg gccgctctat ggttctggtt atatacccca 76200

gagcctttgg ggacaaatac ttctaaatat taatttttca gctatatttt tataataaaa 76260

tttgagtgtg ttcacaggca tatttccttt ctgtctgcca tcttcataat atgagcatgc 76320

ctagtggtgt tgctatgctt tcaaacaaat gatgcataat tttacaggaa tcatgaccaa 76380

acatgcatca tgctattttg tttctgaaac aaagaacttt aaactgagca tggtcatgaa 76440

tgtgcatctt cactgtgcat tttcagaaat gtgtctgctc acaaatcatt tttctatatg 76500

aatatgcaaa ggtcccctga ttaaatgtca ctctttaatt gttgaaggaa ttgtcattac 76560

tttggaaata acctcatgtg tcatctatta cacaaaataa atatttttgt actatgttca 76620

ctctgtaaac accaaaatgt gaattcacag accaaaagaa caattcttat caaatatgta 76680

ttacacacat aacagattca aatactttta gggtgtattg tgttattatt attctcttat 76740

accatcatag gcttctcagt gttctccatt gtttacttca tagcttcgtg ctacatcctg 76800

gttagcatga aattggaatt ttctgtgctg ggcatatttt tgtttttctg aacagaaaat 76860

tccccattca ggctcctgaa aaactttctg catttgagta gaacagatac atttttaaaa 76920

cttacattta aatgttcttt cttttcctat ctaaagaatg ttgttagctt tctggaaact 76980

tctaaacaaa aacctggtcc aaatcaataa acttttataa aataactccc tatggtttag 77040

ccaatgcaca gtaatttata tatttcacca aactaagtga tgatacacag acatttttta 77100

tattatgctg actgaaactt attatcagat gattgagaat tttgagcact agtttgaatg 77160

gaaaattaat aataacaata ataataaata aaatttatta taattttcta aggatatctt 77220

tgttaacatt ttgtgtcagg acactattgc tctaatatga aaatttgagg tttcttttct 77280

ccttttgaga catttgaaag agtttgtgaa gcaggaatga tgtgttggct cagtggacaa 77340

tgaagcttgt caccaatcct catgacttga gttatagcac aaggaaccat gttgtagaag 77400

gaggggatca acacccaaaa gtgatcttct gggctctgtg gcatagacat acatatacac 77460

acagtaaata ttttttaatt aaattaaatt aaaaggtcat aaagtcaagg tattaactac 77520

cactgattat ccaatccctg actttgcttt gaggatgaaa aattttttct aagagaggtt 77580

tttaattaat ttatttattt gtttgtttgt ttattatgta caatgttctg tctgcatgta 77640

tgcctccatg ccagaagagg gtaaaagatc tccttataga tggttgtgag ccaccatgtg 77700

gttgctggga attgaactca ggacctctgg aagagcagtc agtgctctca acctctgaac 77760

catctctcca gccttgttat agatctattt ggttacctgt ctatctatac atgtatctat 77820

ctctctatct gatactttct gccttgcagg agtgtgttca ttttaactgt gcggcctaga 77880

caccaccaaa agattagtta tcaccattct tacagtttag atttcagcaa attcaaacta 77940

atgtagcttt gatttctcat tgtatttgct actctgtcaa tatgacttat ttttttcctc 78000

atgttgatct ctacataata tcagcctttg actttgttga ctttctccct acttctttat 78060

ttttccttaa ttttactata atatgacata tgcagcttcc tctaatacgt ggtttaattt 78120

ggtgttaatg atggaccata ttgagatgag tgtttagatt gttagccatg caatattaca 78180

gtcctgacat aaagacgttg acaactgtac attgtccatt tgctaccatg agtcctagat 78240

aaaatgtaca aaatcctaca aatttggcca gattccattt tcttggaaac attgaaatca 78300

aatgttattc ttttctcctt tgacagtgga ttttgtgtga ccaggctgtt ttatttacac 78360

atatttgcaa atttcaaaat tttcctttta ttcacgactt ccagtttagt ctctatgctg 78420

gtgtttgtca acttgttaca aatctatgca tacctacaaa gttggattct caattgaaaa 78480

aatgcttcca tcacatgggc ctgtaggaaa tcctgtaggg cattttattg attggtggtt 78540

gatgttgaag gcccaaaatc aatgtgggtg ataccacccc taagctggtg gtcctggaat 78600

acataagaaa gcaagctgaa aaagttatgg ggagcaagta agtaagaagc acccctccat 78660

ggcctgtgca tcagttctgc ctccaagatc ctattttgag ttcctgtcct gacttccctc 78720

agtgatggac tgtgatttga aagtggaaga caaatgtacc ctgggttata attgtgtcct 78780

tcatccagcc caaacccatt gcttcctgat tcaccaagat atcagaaaaa aatgtagcaa 78840

tctcttccca acacacacac acaaaattag tttgctttct attgctgtga caaaccccta 78900

taactaaaac ctaacttaga aaaggaaagg gttaacccat cttacacagg tcaccatcta 78960

ccattgaggg aagttagggc agaatcttca atcaaaaacc atgtatgcta tgtattggct 79020

tgttttttaa ctcatgctta accaacttcc tagtacagcc cacaaagcct gactagggaa 79080

tgatgagccc acactgagat gagtcatcca tatcaatcat caatcaagac attccccaac 79140

agacaatccc acagaaaaaa acatgagctg ggcaatccct caattgagac ttccttccta 79200

aatgattcta aactgtgtca aattgaccat taaagttgac tacgaaaaaa aaaatagaga 79260

ctcttcatct gcgccatgtt tcccaccatg ataggccaca ccttcaaact agggaccaaa 79320

ataaggcctt ccctcaattg actactgtca ggtattaaat caaagtacca aaaagatatt 79380

tatatgggtc tctaagtccc ctctctagta ttaacaacaa actatatcaa caactgtcta 79440

aactatcagt tgtagtaaga aagtgaaata actctggatt aaaagtctct acagttaaca 79500

agcactaaat acttccagaa caactgctgt aattactgtt gaatatcaac ctgacaggat 79560

ataggatcat ctataacata aaccctttgg tatatctgtg agaatgcttt tagattggta 79620

taactgaggt gggaaatccc tccctaagtg tgggcactac tatttaatgg catttgattt 79680

tgtataccct ttcctgcttg tatcagagga gttaggggaa aaacaaaggg gtaagtgaca 79740

aggggaagaa ggggtgtcct tccccacttg ggtaccacag aacttaatat ccatcaaagc 79800

ctacctgatc agtggctttg aggatcttct ttaatgaatt tgaagaatat tatttgagga 79860

ccccagaggg tggattattt gtcttgaatt gggtacttgg gtgaccagtg ggtgggcact 79920

ttagagtgag aaagagacat agcagagctg ggcaaggtca gggctttggg tgataacatt 79980

atgatctgaa gggattttga caggatttat ggtaattctg aggtgcttca tagtagtgaa 80040

tgagagggat taaaactcag gctgacatcc aatttcaggt acaacaggac tgaatgggac 80100

atcatcgcag tattatttta acaaaccacc caccatgaat ggcatggaaa aaaggctggc 80160

aagtgaattc tttatggttg ccaccctctg gcttggagta ttgcccatgc tgacctctaa 80220

ttcctggaaa aacaaaaact taagaaaaca aaactagttt cctattttca aataaaaatt 80280

gaatgactta cttacaagaa aattctcccc attctaatat tttatgtgag agtttgaaaa 80340

gcgttttttt ccccattttt tattaggtat ttagctcatt tacaaaattt gtatattctt 80400

ttttttcttt tttttgtttt ttttccattt tttattaggt atttatttca tttacatttc 80460

caatgctata ccaaaagtcc cccataccca cccacccact cccccttttt ggccctggcg 80520

ttcccctgta ctggggcata taaagtttgc aagtccaatc ggcctctctt tgcagtgatg 80580

gccgactagg ccatcttttg atacatatgc agctagagac aagaactccg gggtactggt 80640

tagttcatat tgttgttcca cctatagggt tgcagttccc tttagctcct tgggtgcttt 80700

ctctagctcc tccattgggg gccctgtggt ccattcaata gctgactgtg agcatccact 80760

tctgtgtttg ctaggccctg gcatagtctc acaagagaca ggtatatctg ggtcctttca 80820

gcaaaatctt gctagtgtat gcaatggtgt cagcgtttgg aagctgatcg tgagatggat 80880

ctctggatat ggcaatcact agatggtcca tccttttgtc acacttccaa attttgtctc 80940

tgtaactcct tccatgggtg ttttgtttcc tattctaaga aggggcaaag tgtccacact 81000

ttggtcttcg ttctcttgag tttaatgtgt ttagcaaatt gtatcttata tcttgggtat 81060

cctaaatttc tgggctaata tccacttatc agtgagtaca tattgtgaga gttcctttgt 81120

gattgggtta gaaaagcgtt ttttttccct aggtttattc atattaaatc tttggctgta 81180

aattctcagc atttttgcca gtggatttga acaactttgt gtgctgaact gttgaactgt 81240

gaatgaatga atatgaatat gcaggaaaca gatttttgcc tgacatctta atcatttctc 81300

agccacttaa caaggccaaa ttcatactga aaaacaaagg cttattggat tatctacatt 81360

gggaagatga acaaagagat ccagtaacct accctcactc acccccttac accaccccac 81420

ccaaccctaa cgctacccca ccctcattcc cttaccactg ctaccacatc accacgccac 81480

cattacccct atcctcaccc ctggtaacaa acccattgtc agggtcctga cataaggtta 81540

aagtagcagt tctggtgaag ctgtggtccc acccatacct gaccccgcag agagtctatt 81600

atcctaaaat gtgaacttaa aagctgtcaa actctctcag ggaaaaattt accttctacc 81660

tagtctgggt ttctggattt gtcttctctc gggatgatat ccctgaggaa atttcagact 81720

tttgagtccc attatttgga tattccagaa actagaggga atggtacaaa gtccttaccc 81780

ctacccccaa ggctggttaa agcatctctc tatagaaaac tatcatggga ggcttaactc 81840

tgtgtagaaa ctcgcagcaa aaaacaatgt tttgtctacc ctcaaattat ttccatttaa 81900

atatttatta cagtattctc attattgttt taaaaataaa actgtggtta tgtagtggaa 81960

acactgcctt aacaactatt ttaagattta ttgtatatgt taggtctcaa aactgacctg 82020

gctgtcaggt tctctcacca tctctaagtc gttacctgtt acagggtatg gccaactccc 82080

tacacaaaat ttctctagct gggctgctct tccctatata atgcatccat tttgatcatt 82140

cagccccttt ttgtctagcc tttttccctc ttgagctctt gatctcctgg ctttccactt 82200

cccactctcc cctctccctc tgtttacatg cccctgctca gggacctgtt gactctggac 82260

tctcccagat gtgcctgcct ctgcttatgc tctcctgata tctacaataa acctatcatc 82320

tatatctaca ataaacctat ctatcatacc taggagtagt cacgtcctga tttttatttt 82380

ttcattcaat atatgcatat aaaatttatt tcagtgcctc aaaagacgat ggagtaaaca 82440

tggctttgtg actggtttta catttatatt taggaatatg tatgtatata catatatgca 82500

tgcaatataa ttcatttgaa atggggcatg gacttgaaag agagcaagga ggggtatatg 82560

gaagggttta gagagaggaa atggaggggc aatgatataa ttatattatt attatctcaa 82620

aaaaataaaa aggagatttt aaaagtaata caatattgga ggtggagtga agaaccctgt 82680

tcattcccca gcaccctggt gggcagcaca caaccacctg caaatccaat gcctatggat 82740

cctacaccct ctttcagact tcacacacac ctgcaaaaag aaataaatgg cccacacata 82800

aaaaagaaat tcaactttga aaaagtagtc ccacattaga aacattttta aacacacctt 82860

cttcctggaa tcactatgtc accttttatc tggttttact gaagaacttt catcaatgca 82920

tcaataacat tttattaatg tcataaaatg aataaacgcc ttgaactcta ggaaggaagg 82980

aaggaaggaa ggaaggaagg aaggaaggaa aggagggagg gagggaggga gggagggagg 83040

gagagagaga gagagagaga gaaagagaga gagagagaaa gaaagagaga gagagaaaga 83100

gagagagaga aagaaagaga gagagagaaa gaaagaaaga gagagaaaga gagagagaga 83160

aagaaagaga gagagagaaa gaaagaaaga aagaaagaaa gaaagaaaga aagaaagaaa 83220

gaaagaaaga aagaaagaca gacagaccaa agcatatatt tcaggaaggg gaatgcaagt 83280

gccaattcag aggtcacaga gggaaaaaag atcattggta ataaatgaaa atgaatgagt 83340

tgttatctgg cctggctgta tccattccac tggttagaaa caaaactgaa tgtcaccata 83400

gactgtaatt gtaacaaccc ttcacttttg gcatcaatct cactgtaaga aatccacatt 83460

gggaataaat caattcagga agtgtgagtc cttgaaggga atactaggac cccagtatca 83520

tttttcctct ctctctctct ctctctctct ctctctccct ctctctctct ctctctctct 83580

ctctcctaca cacacacaca cacacacaca cacacacaca cacactttca gtcatttatt 83640

tattgctaga acctcctgta gttccctgtg gcctccacta tgtaactgag catgaccttg 83700

aagtcctgaa ttcctgaccc cttcccctgc ctatgcctct catatactga gaagatggat 83760

gagacacaca caccagacct tgacatttat tattattgtt attgttgttc aaagtctgac 83820

ttttatgtaa tttacatgat ttctccttca atagttaaat aggaaattac tgattccaat 83880

tctctatcat taattcaatt acttggaagc taatgctaaa cagcacatga taggaatata 83940

tattttgtgc acttgtcagc atgcacctaa caaaaattga ttaccctgtg tagtgatagc 84000

ttttgtactg gctggttttg tgggtcaact ggacacaagc tggagttatc acagagaaag 84060

gagcttcagt tgaggaaatg cctccatgag atccagctgt ggagcatttt ctcaattagt 84120

gatcaagggg gaagggtcgc ttgtgggtgg taccatccct gggctggtag tcttgggttc 84180

tataagagag caggctgagc aagccaggag aagcaagcca ataaagaaca tccctccagg 84240

gcctctgcat cagctcctgc ttcctgacct gcttgagttc cagtcctgac ttcctttggt 84300

gatgaacagc agtatggaag tgtaaactga ataaaccctt tcctccccaa cttgcttctt 84360

ggtcatgatg actgtgcagg aatagaaacc ctgactaaga cagctttata gagatcttgg 84420

catagaaact ggaattttag aagaaaaaat aagtggaatg ggttaaagtt tgaccttcaa 84480

gtgtggattt ctgcttcact cttatctcag caaagcaaac acctggcaga accttccaga 84540

aggagtgatg ggcacagcta cctgaaaaga ttctgtttgc ttagaaagga attgttcctt 84600

tattgttccc tgccagccca gtcctggaag ccttgataac aaatatttgt acatttttat 84660

tgttccccgc aaaatcatcc tctcataact gcagatcctg tcaacatgcc tgccagatgg 84720

cagaaatcac ctatcatgtg acctataaaa gctgtgagaa attatggggt gtttgggaac 84780

ttttcaaagc atcagcccag tcatagctac aaaatttctt gtgtctccca gggcctgctg 84840

ggttgattcg tggttggagt tttccatagc agcacacaag tggaaaatac attttggtag 84900

aatcacctca ttggtgtcaa ttgatttcat aagaaaaatt aacagtcaca ataagattgg 84960

gtactttcaa agttccctat gtccaaatag tatcccattg tactctcaga acaagtgaac 85020

attgcaacct ttatttcaaa agattaatat tctaattatg tttatatcta ttatatattg 85080

tattatacac acacgtatgt actatgagct ttatttttac acttttattt tagtattaat 85140

tgtgtatatg tgtgtatatg caatacatat tatattacac atatatatgt acattacaat 85200

ttttatttta aaatttttca tttcagttat atgtatatgt ggagtggggc agggtgggca 85260

catgtgagta tagtaccatg agaggccagt agagggtggt gagcccccag gatcaggaac 85320

aacaggtgtt tgtgggcttc ctgtgtaggt gttggaagct gaacttggtc cctatttgtt 85380

ggccttgctt gtgggggatt acatgctaca ctttgctgga ggaattacat cagtggggga 85440

gagctatttg agattctgaa acattcagca agttctgttt ggttggagat gggagctctc 85500

agctccttgt tggtgccacc ttgccagccc cttcctgctg tacttgtccc ttatgtgtgc 85560

ttctgtcaca gccatgccca cccctcacca ctatgcttcc ctgtgccaac gaactcatca 85620

ccctttggat cttaaatgca taagtcaaaa tatttcttgc atacactcat tttgtttgtg 85680

atatcttgtc acagcaacag aaaactctta ttgcttaaca ctaagctacc tctccagccc 85740

ctagaggttt ttggtttggt ttggctttta atatcatttt ttttttattt atgtgtaggg 85800

gtgtgtgcct gtgtgagttt tccccattta atttatttat ttattcattt tacatgcccc 85860

cctccttgtc cccactcaca tcgtctcttc cccattcccc ctccccttct cttctgaggc 85920

ccctctgggt attccccgat cctggcacat caagtctctt cagagctagg tgcatccact 85980

ccctctgagg caagacaagc agctcagtta ggggaacagg ttccacgaag atttgagaga 86040

aggaatgaag gccctaaagg ggatagaact ccacaagaag accaacagag tcaaataatc 86100

tggaccccga gaggctctca gagactgaac caccaaccaa agatcctaca tgagctggac 86160

ctagccctcc ccacccccac cccccacata tgtagtagat attcaattcg gacttccaat 86220

aggagctgtc cctaaagctg ttgcctgtct gtggaatctg agagattagt tttttgtttt 86280

ttgtttgttt ggttggttgg ttggttgttt tgggtttttt gggaggattg gggggctgtt 86340

tgtttttgtt tttgtaccct gaaagttctt caatggaata gttctcagtg ttgcttctat 86400

ttcattcatg ctacccacag gcttgctttt gaaattacat gtatttttcc cattttcttc 86460

tctctaaatt tgagtcaatt tctggtatca gcatgtttga aacaccaagc agaataatgt 86520

gtctgcttta ttttatattt tgtcgtactt atgcacatgg aaacacacac acatgttatg 86580

tgctcaatta ttggaacaaa tgttttcctt ttttatctac tctcactatg tgacccttta 86640

tttgtttcaa gtaaataaaa taacaaactg ataatcaaac taataaaact gtaacattta 86700

cagatgatgt cattatttgc atcatctaat tctcatggaa aaggtgccct ttttcttact 86760

aatgctactt acaggtagac actcttagcc aaaaataatc cggaagtgaa actgcctgcc 86820

aacacaaacc actgatgact gataagattc ctgaggatta ggaaaaccac acggttctta 86880

cagggaacaa ctgattcttc agagactgcc taagaaaaca ctgacacatt tgcagaaaag 86940

ctattgagtt ggataaaagt tttacaaaat gcccacaatg aattttaata ctaaacctgc 87000

aaaagaaata tgctaaggaa atcacacaca cacacacaca cacacacaca cactaccacc 87060

accaccacca ccaccaccac caccaccacc accaccacac aaataaatgc ataagccaag 87120

tcctgagggc ctgggatatc agccccaaat tcagtaggct gggtaagaag gaagccagga 87180

ctctgtttta agatgaattt ctttcaaaat ccacaggaac acatcatgca tatcacatca 87240

tgtgctatat cctggccctg gggttgtgga gtgtccaaga aggatgcgga ggcacaggtt 87300

atgattaatt atctgagcat atcaagcagc aaactcagac actccttcct cttctgtctt 87360

ccaaaggatg tttgtttcgg gacattttct agaaagacag gtaccaatgt atattgacag 87420

atgaggcaca ccaatgatag tcaaaggaaa tttttcacat gagtctttct gggttgactt 87480

acaggagggt gttttccacc atcacatatg gaatgtttca ctttctgcca tttcacatca 87540

gtaaatataa atattgatga gtgggcgtcc ttccttcaag acatgcattt aattgggttt 87600

tgatcaaatg ttcaggcact gggaggaagc cagtggcatc aaagttgtcc acaaacccaa 87660

catcacacta ggggactagt gtgaaaactc agtaaaagtt gcccaagtca tgtatctgtt 87720

gttgttgttg ttgttgttgt tgttgttgtt gttgtcatcg tcatctttgg aggtggtggt 87780

ttggtttggt ttgggagtgt ttgtttattt tgtttgagac agagtctcac ttcatagctc 87840

tgactgatct ggaactcact atgtagacca cactgaccct gaatttggag agatcctgcc 87900

tgcctctgcc tcctgagagc tgggattaaa ggcatgcacc actgtgacat gcaagttaat 87960

tttttttaat tatatttttt ctacaactaa cattcatcag tgtttcagcc tggaaggaag 88020

aaaacttgca tgcaatcaat gttttaattg aacaagaaca tatgcaaatg gcacaggcat 88080

ttctatcatt tggatttaga agaaaatccc aagatgatgt tgcagttttc ccacctcagc 88140

tgtgaacact tactattcgt gattgagtct gcaggcagtt ggcgggcaaa agcctgtcag 88200

gggtattatt agccttcata ccagatcata aagaaggatt tgccaaaaat cctagtttcc 88260

agaagagctc tgttgtacca aggcagtgga gcatcgccac cttacgactg taccttgcaa 88320

tgcaactagc tcgcacaaat tacaaatgct atttattgat tggggcaggg aggggaaaaa 88380

aggggagggc agaggcagac tgttggttgg tttggttggg ttggttggtt ggtttgttgg 88440

ttggtgattt ttcaagacag gatttctcta acagtcttcg ctgacctgaa ctccttctgt 88500

acagcagtct agcctcaaat tcacagagat ccacctgcct ctgattctcc agtgctgggc 88560

tcaaaggcaa gcgccactac tgcctagcct gtgttgtttt ttggttaagc aaaacatctt 88620

taaatgtcta gattagatat ccagattaaa tgtctagact aagatctcta aacattttct 88680

aatataaatt ttatcagttg aaacttgtcc acttttatgg gatgctaagg atgtatggaa 88740

ctcaggactt tgtgcattca gtcccactgt ctggtagaca ctgttatgct gtatattcct 88800

aatggggagc agccaaaaac aaaaacaaaa caaacaaaaa atccaaacct caattcctta 88860

attaattaat taattaattt tttagaacta agatttaatc aggaaagttg cattatatgc 88920

atacccctgg ttattcaggt aagcatagta agaatataat taaaagttgt ctgcacattt 88980

gaatttagat ggatatgaaa gtgtttcaga tttcctactt aagtaaagtg aaacaatatt 89040

gaaatttttc gaaggttgtt actgtgggat cccgggtcca cagacacata aaataaatct 89100

ttgaaaaaat aatattaata tttagtaatg tgacatgaaa ttaaattaaa ccaatgtttt 89160

tcctctggca agaaacgcag aaagtaaaaa tgatacattg tattcgtggt aaaaatccta 89220

atctcattta atcgatacac attgcatcca ttatgagttg cagtcattaa taataaaata 89280

atattattaa gcagcaagca aatagtctta aagcagcacg tagtgagacc tcagagctgt 89340

taatttccta ataaaagaat acacttccca ggaaacttta cggccaggcc aagcacttcc 89400

ggaaggaggg actacgggac ggcaatagga cccttctgta agaaaaggga gaaatgtggc 89460

ttcaaaagaa accatactta ttcatgtgag tggcgatttg tcacatgtgt gtgacgatag 89520

ccaatatgtc tgaagagaaa gaccggttgt ggcgctaact ggggggacct actgcctccc 89580

tgtaagcctt ccttacaagg ctatctcggc gcaaggaatg ctggaaagtg tagtgatttg 89640

gctggaaact accagctatt aagtaaaatc gcgtcatcac cccgaccagt tctgttccca 89700

agcctgctga tctagacctt atcccacctc cgttcctgct ccattctgag ccctgactgt 89760

gaaggtttca ctctcttcac ttacaggagc tttagggaag aagtctccca caggagctga 89820

gggtgggggg cgggcggtct ccctcttctg gcctctatcg gtactgcaag gaggggccac 89880

caattacatg caatttttat gccacactaa gatgcacaaa taaataaggc cagagattcc 89940

ccagagtcag gatttgaggc tttggggacc aatgagagtt gttggattga atgcaaaatg 90000

tacacacttg gaaacaagac tgggcaaggc tgcattttct agtctgcagg gagacctgaa 90060

aagttagtag aagtacatgt gtgtgtcagt tctaaatgaa acgacggggg acaaatgcct 90120

gaggtgcctg ttagcatacc aaagcacatg atggcctcta gactcacttg ggaccgctga 90180

ctatgctcta ctcttctgat ctggccccat aacttaatcc aagccagacc ttctcctagc 90240

atcttttacc tatataacca gccatttagg ccatgctccc acttggtcct ctcagtctcc 90300

tctgttccct ctcttttctt cttctcttat tctcctcacc ctttccacct ctgtcctctc 90360

atggctgggt tcagtctact gtccaggttt agtccactac tttctctgct ctggactctt 90420

ccagaagcct ctggctgttc ttatccgtac ctgggagtgg ccataccctc atttgtacag 90480

tatcttcctc cagcgtctcc ctgtggctga ccctggaggc ctttatgctt tctccctgga 90540

aaaattctaa ttgggggggg ggggggaatc cagtttgttg caatgaccag acagctgaag 90600

gggtggctca agggccgggg cataggtcat tgaaatatac tcagggctac taggagtggc 90660

agtcagtgtt caagtacaca ggaagcaact ttctctgcaa aggtataaag aaaagtaaaa 90720

agttttgaaa aagctaaaaa tttaaattaa attaaagaca atcatctggg cagtgatggt 90780

gcatgcctta aaaaccagca gattagggct ggagagatgg ctcagcgatt gagagcactg 90840

actgctcttc cagaggtcct gagttcaatt cccagcaacc acaagatggc tcacaaccat 90900

ctgtaatggg atccagtgcc ctcttctagt gtgtctaagg acggctacag tgtactcaca 90960

tacattaagt aaataaatag atttaaaaaa aaaaccagca gattatacat gggagacaga 91020

ggcaggtgaa tctctgagtt cgaggccagc ctggcctaca gagaaagttc caggacagca 91080

aaggctatac agagaaaccc tgtcttgaaa aactaataaa ttaaattaag aggacaacaa 91140

aggtgagctg agtgctttct gggccagtga gtccaggtcc tcttaccctc tgaaccacat 91200

ctccagtccc aaattaacct ttagtttcta ctccccagga acataaaaca agccctggac 91260

cttataaaag gtgtcaggag ataagagcag cctaaggctt ctttatttct ttcctctaca 91320

ctcctggaaa agaaagggta gcaggaaagc cagtggtcag ataaaataca aattgtcaga 91380

ttaaaatctt aattctggtt gtatttattt tacactctct gaggactcat tgccctacag 91440

tatgtttggg gactagaaag gaaatgaaat ctcagtgtca gtagcccaca aagagacaga 91500

agcaaaagta gtttgcaaag gacagtgaga aagtcctctg atgttctctc cctctccctt 91560

tccttctacc ctcttctttc tgcatttttt tttgacccag ctcctgtgac ccccatctcc 91620

aaccctttga tccagtagga ctttcaagtt ttctgaacag tgctcaaaga aaacacttta 91680

cttgtggttt tccatatcct ctgaggtctg gactttctgt ccccagccag caggtggtgc 91740

tgttactaca gctggaagca aagttcccaa aacgtagctg aacacctggg aggctgattg 91800

actggtagtg tgtggagatg tgcagagttg gaatcctgag agtccagagc ctaattatga 91860

tttctcttgg acaattttca gctctctaga tagatgtccc taagccacct atgtcagacc 91920

tgacgtcctg tgactaacag atttaaaaaa caaacaaaaa taaaacattt ttttttgtct 91980

gtctaatttg atcaaattgt tctttcacag caaagggcct agtaaaagca aggacttctg 92040

gctctgcttc atccacctgg cttaatattc ccactcatgt attttgaaaa gaaccttgat 92100

tgatgttcct ataaaaactt catgaaactg tgtctatgtc cctccatggg atttggggat 92160

gcagtttacc atgccttacc gcaacctgat gtgtggaacc ttcaaactgt ggcttaaaac 92220

aaactcttct ttcctttaaa gtgcttgact caagtatttt gtcgaagcaa tgtgtagggt 92280

aactaatacc cttggataga ttaaatcagt ggaaatacac tctctgtcac tggatgagaa 92340

cgtgctttta gcaaggctca atggcatctt tcatcctacc cagcacttag gaagcagagg 92400

caagggaatc tctgagctcc tggcctgcct gatctacata aaggatttca gtccctgtga 92460

cacttactca ataacagtga caggagagaa tttggttccc aggaacttgg agatgggggc 92520

gggatattgg agaggttggg ggaggatgtt ggacagctgg ctaccatgtg agttccaaat 92580

ttaggtggac agtgatagag gggggtattc catgccccct ctacatttcc atatgtgcac 92640

atatgtgctt atctaaatga gtcattttat tactctttga ttcccatttc ccaatttcct 92700

tctatcaaga gagtaaagac aaaaaacaaa tccattattt tttttgtgtg taaattcttc 92760

tgctcatgaa tattctatgt attttagttc cctaaaaaca aaacttcatt aaaaattttg 92820

aaagctgccc ataatttttt tgacatagag gaattcaagt tatacattca attttacatt 92880

ttgattgcat tttaaagcat gggactactg cagctcaaag cagctgcaaa tctcaaacct 92940

tcctgcctcc acttcccagg cactgtttac aggcatggag ctccattatt ggatatagaa 93000

acacacaaag agaaacatac acacagacat acatacacac atataaaata ggctttgctg 93060

gaagaaaata aacaagaaca aaacagtgat tattcagttt ggtcaggccc aagttccaag 93120

gctatacaca tctgtgacaa gaatttcaga tataaacatg tgaaggaaat tttataggtg 93180

cacctttttt atttattttt gttagatatt ttctttatat acatttcaaa agctatcccg 93240

aaagttccct ataccctccc tccaccctgc tcccctactc acccactccc acttcttggc 93300

cctggcattt ccctgtactg ggacatataa agtttgcaat accaaggggc ctctctttcc 93360

agtgatgacc aactaggcca tcttctgcta catatgcagc tagagatatg agctctgggg 93420

acactggtta gctcatattg ttgttccacc tatagggttg cagacccctt cagctccttg 93480

ggtgttttct ctagcttctc ctttgggggc cctgtgttcc atcttatgac tgtgagcatc 93540

cacttctgta tttgccaggc actggcatag cctcgtacaa gacagctata acaggggctc 93600

ttcagcaaaa ctttcctggc atatgcaata gtgtctgggt ttggtggctg attatgggat 93660

ggatccctga gtggggtagt cactggatcc tttcgtctta gctccaaact ttgtctctgt 93720

aactcctttc atgggtattt tgttccctat tctaaggagg aatgaagtat cttccctctt 93780

cttgattttc ttgtgttttg caaattgtat cttgggtgtt ctatgtttct ggactaatat 93840

ccacttatca gtgagtgcat atcaaatgac ttcttttgtg attgggttac ctcactgtct 93900

tagtcagggt ttctattcct gcacaataat catgaccaag aagcacctgg ggaggaaagg 93960

gtttattcag cttacacttc cacattgctg tttatcacca aaggaagtca ggactggaac 94020

tcaaacaggt cagaaagcag gagctgatgc agaggccatg gagggatgtt ctttactggc 94080

ttgcttcccc tggcttgctc agcctgctct cttatagaac caagactacc agcccagaga 94140

cggtcctact cacaaggggc ctttccccct tgatcattaa ttgagaaaat gcagaaaatc 94200

aagaatttca cacacaacta tgacaggcat ttcatacaca tacacatatg acaagaattt 94260

ctctctctct ctctctctct ctctctctct ctctctctct ctctcacaca cacacacaca 94320

cacacacaca cacacacaca cactcctgtg acaagaatac catacataaa actctggtag 94380

gaatttcaca tacaaacctg tgacaggaat ttcacataca cacataccca cagacatctg 94440

ttaaatgaat tttaaacaca catgtgacca gaatttcaca cacacacaca cacacacaat 94500

cacctgatac aggagtttca ctcatacaac tgtgacatga attttatata cacacgtatc 94560

tgtgaaatga attttacaca ggtacatgtg acaggaattt cacacacaca cctgatataa 94620

aagtttcaca catatacatg tgacatgaat ttcacataca cgcatatcag tgaaattaat 94680

tttgcacaca cacatgtgac aggaatttca cacatacaca tacctatgac aagagtttca 94740

cacacaacac tgcaatagga aatttaacac ccatacaaaa cagtgatatg gattttatac 94800

acacacacac acacatacac atgtaacaaa aaattcacac acaaaactgc aacaggactt 94860

tcacacacac acaaagctgt gaccagggtt cacacacaca cacacacaca cacacacaca 94920

cacacacaca catctgtgaa atgaatgcta cacacatgcc tgttaccaga aattcacatg 94980

cacacacata cacacatacc tgtgatggga atttcacaca cactgtgaca ggaatttcac 95040

acatatgcac aaactcctat ttcaggagtt tcacacacac acctgtgaca caaatttcac 95100

acacatacac acacacacac acacacacac acacacacac acacacacac tgtgataggg 95160

ttgttaataa gtagctagct agatggatag ttgaatgatg ggtgggtggg tgtctgtact 95220

gatggaaaga tacccagagg tgatgaattg acatccagag gtggacatat ggatggaaag 95280

aggaaggcat gaatactgaa caaatggaag cattggtgaa tggatgggtg tatgaatgga 95340

tttgtcgtgc atgtactggt agagggtcta atgagtgtat atatgagtgg gtggctggct 95400

ggctggctga atgagtgagt ggatggatgg gtgtttggga ggattgttaa agttcctttt 95460

gttctcctga tataactatt gttttaaagg cttattgcct ccatctgcta acctaagcct 95520

agtcttggaa gcttctagcc tccatacaat cttatctagg cctagaatct tttcaacatt 95580

tgagacttgc tgctgaatat gctcaccttt tctagttatt tctgaactcc tgctagctgg 95640

tcaattcagc agttctggct cagaactctt ttccatgcta actgattcaa tcttgcttct 95700

cttggcttct cttgaatttc tctacttggc ctcataataa ctttggcaat atgttctata 95760

cagaagtata tggctccttc tcattctctg actcattctg tcttctcctg tgtcttgctt 95820

ggtctctctc tctctctctg caatctgcct ctgtacaact gtcccagtaa aactgcctcc 95880

ttcctccccc ctccactctc tgcactgctc tcttaagtag cttccctttc ttctctcttc 95940

ttataggata tgttacttcc tcctacaaac taactttacc ttcattgttt gggattaagg 96000

gtgtatacca agggcatgtc tatattccag caagggggat taagggtgtg tgctaagggt 96060

gagccacacc acaactagaa acaggttttt ccagtaaata attcaatctt gggtttccca 96120

gtgtgatcaa atatcctaca acagtgaatg gatagtaaga tgggtggatg gattggtgga 96180

ttgtgagtag atagatgaat aggtgaatgg atggataggt ggttggatag gtgggtgggt 96240

gaatgaacag gtcatgtatt gtggatgtgt ggatatatga gagggtggat agatagatgg 96300

atggatgggt gggtggatgg atggatggat ggataggtgg atatatgtgt gagtaaatga 96360

atgggtgggt ggatgaatgg ataggtggat atattggtgg atgtgtggat tagtggtaga 96420

tgggtatgtg gacacatgga taaatggatg gatggatgga tggatggatg gatggatatg 96480

tagatggatg tataaatgga tggataggtg gatggattga tggatgtgta ggtgtcagta 96540

aatggatgga taaatgtata ggatgatgaa tgaagggtaa acggatgtgt gggtgggtgg 96600

ataaataggt gtgtgtgtgt gtgtgtatgt gtgtgtgtgt gtgtgtgtgt aggtgtttgg 96660

atggatggtg gatggatggt ttagtggatt ggttgattgt gaatatgtga gtgaattgat 96720

gactagatgg gaatattgaa gtttgaataa atggatggat gggtttatgg atgaatggat 96780

ggataagtat atgtatggat atatatatgt gtgagtgggt ggatggatga atggatgagt 96840

gaatgggtga gtggatggat ggatggatgg atggatggat ggatggatgg ataggtggat 96900

gagttggtag atatgtggat gtgtgagtgg atggatgaat agatggatag tgaatggatg 96960

gtgtagtggc tattcctggt tgtcaacttg acaatatttg gaatgaacta caatccggaa 97020

ttggaaggct caccagtgac ccttatctgg aggcttggag atccttatct ggatcttggt 97080

ttgaagatct tgagccatag tggctatgga ttccagaaga ttgaatctcc gagtttaagg 97140

aacacaccct taatctgggc tacgcctttc atctgggatt aaaggtgtgg tggaacacac 97200

ctttaatctg ggctccacct tctgctggag acaatataag gacattggaa gaagggagtc 97260

tagctcttgc tcttgctcct ttgcctgctt gctgcgtgag actgagtaac tgctagatcc 97320

ttggacttcc attcacagct gcgactgaac aattgttggg aattcggctg ccgactgtaa 97380

gtcatcaata aattccttta ctatttagag attatccata agttctgtga ctctagagaa 97440

ccctgactaa tacagatgga taagtagatg gattgatgga tggatgtttg agtgggtggg 97500

tgtatgtatg ggtgggtggg tggatggata gaagaatggg tgtactgatg gagaatatgt 97560

tcatcaatgt tgctttgtaa caacccaatt gtaagcttct attcaacaat gtactgcttt 97620

ctttgttccc aaggtcatgc cttatctgtg atgttcaaaa tgaattcaca gccagatctt 97680

aacttcccat ggccgactgt gagcaccaag gatcttaaat cactgacacc acattccttg 97740

aaccttgacc ctgaaacatc ctggtatgga tgtgacatca gctcagctgc aatcaggact 97800

atatgagagg gaactgagaa tgttcatttg tagagcagag agacaatctc tacacagccc 97860

acatgaagaa gaaagtggag aaaggggagg cagaaaggaa aagggaagag ggatggactg 97920

aatgaaggga agggaaaaga tcagtaggga gactacctcc agaggtggtt caactacaga 97980

agcacagcac agaagtctct gcttcaaaaa tagaattgtt tgcaaactcg ttcctctttc 98040

tcatttctcc aaaagaaggg aggggctgga atcacaccca tggtttaatg ctaaccagga 98100

acaatggagt agatgctgct aaaagtgaag gacctgctac aacttctgag aaactacaaa 98160

gtcacaatca agtaccctaa gcttggcctg gatcacaggg tgcttctaga agtgtgactc 98220

ttctaaaaga ttctacttca tacaaggccg tgacttttca aattcacctt taatttgaag 98280

ggctggtttt atgtatttat cattgtcagt tctttatcca tttacttaat tttttgttgt 98340

gtttatttct ggtttttcaa gacagggttt ctctttgtgt agccctgcct atcttggaac 98400

acactctgta gaacaggctg gcctcccact gaaagatcag cctcccaagt tcttgtctta 98460

caggattaaa ggcatgcacc accactgact ggttatttaa atatttttaa gattttttaa 98520

aattgtatat agttttttcc cataatcact gtgggaggta catggggttc agattttgga 98580

taacacatta caaaatctac cacaggagga tactcccttt gaggaggcag atgttttcta 98640

aagaaaagta tttatttctg tcgcccactg tccagtcaga ctcatttaaa gaggaatcaa 98700

ttgacaagaa aactaactgt gcaggggtct ggccagaaga gggtcacttg gaaggttctg 98760

tgaaaggctg agtcaacaac aggaagttga tctgtgtggt ttgagatagc atctggcctg 98820

gcctcatagc agtgacaaac atttcctcaa aaaagatact gtgagaatga gttaggttga 98880

gtgagaaagc taataccaaa actcacctat tatgatttat tctgtaagag taaacatgtt 98940

tttaataagg aaaaaataaa aaagttgtgg agaacaaaaa acaacccagc actaactaaa 99000

catatttcct gattttaaca ttcacaattt tggggccagc taggtggctt aggaggtaag 99060

agtgtttgtg accaagcctg ggaatcagag ttcaattctg ttgtcccatc cagaagctga 99120

ctttgatttt tacttttatg tattgttatg gcatgactgt cagaggacag cttcattgcc 99180

atcagctctg tctgtccagc tttccatggc ttctgaaaat tgaattcatg tttccaggct 99240

tgagtatagt cttaggatat ctaatattga aactttttct tttttttttt cactaaaaaa 99300

gtgaatttag cttgtgacta tgtcctcgca ctttcgagtg tgttgagtgt gtgtgtgtgt 99360

gtgtgtgtgt gtgtgtgtgt gtgtgtacac cttttctcgc tgtatcaaga atctaaataa 99420

ttttggcatt ttctgccacc cactgtaagg atcacaccaa ggtgaggaat ttctcctctt 99480

ccaatccaag cacacatttc tgcaatttta tcaaaactgt ttatcattat tggactgaag 99540

ttcatcaaac ttcacctcct attcccctca tctgagcaga agcaatgtgc atttttcctt 99600

attgtgtttg tttgtttgtt tgtttatatt ttggattttc gagacagggt ttctctgtgt 99660

agcactggat agtctcaaac ttgtagacca ggctagcctt gaactcacag agatctacat 99720

gtctctgcct cctgggtgtt attttcttta gattctgcaa tattattgta aacacttccc 99780

aggtagggaa ctcaaactta aaaattcgtt tacaatttcc tcataataca cacctatacc 99840

ctcagtagaa tttcatgtag tgttctttgg ggatttgggt ggtttgcttt gttttatttt 99900

tctgtcaaga gacaaggtct caccatgcag ccttggctgg cctagaattt acagaaatcc 99960

ctctgtctca gtttccttag tgctggcctc acaggcatgc aatatgcacc ttttagcaag 100020

tttttaagtg agggtctgta aagtttccca agtttactta gtttatagtc cttgaccctg 100080

gcctgcagcc accaagtagt cacctgaaag aaaagaaaat agaatttgca gctatttttc 100140

atgagaaacc aaggtggtat ctgcagagat ggagactgag tcatgaaaag gagatagagt 100200

tgccacagag aaggttgctg cccaagggaa acttactctg ctgagctcca tgctgtgacc 100260

ctgaaaacta gagtttcaca gatgatctga gactagggga tatgttcgag tgtcttcaag 100320

gattgtccca agtgaatcca tagtaaagca gggataatcc atggatctaa aaggaaacaa 100380

caggtgccca tccagtcatg aaatagttaa tatccagact tgtaaaagca ggaagttcct 100440

agacactaaa cgaatgaatg aatgaatgaa tgaatataat aaaagtatgt atggggctag 100500

agagacagct tggcaattac aagtacaacc tacctttgca gccaacccaa attcagttcc 100560

cagcacccac aaggaggctt ataaattcca caacttcagc atccagatct ccatggtcaa 100620

tgacttctga cttttagaaa acagatccaa cttccagtga cataaactct gaagctttaa 100680

ccttcctggc tgttttgttt tccactagaa cctgtgactg aagccctact acaacacaac 100740

ccccaccata catacataca cacacacaca cacacacaca cacacacaca cacacacacg 100800

taacttgatc cctgactgaa agcaagttct tactttcacc agagtacttg agctccaccc 100860

acctcctcgt caatcactta actgaccaca agaaaatcca aatgctttgt tgacaagatg 100920

catctatgga cactacaaca aacccacaaa cccttcttaa acatagtttt taagtctaca 100980

gaagattcgt atctcacctt tccgaggcta tttggagcta ggctatactc actaggtagt 101040

gcttacagct cagtggcaaa aatgcttata gctactagga taaggtgttc aatagctcag 101100

tggatagggt gcttgaagat tagtgagtaa tgtgcttgta gctcagtgtc ttagttagtg 101160

ttctattgct gcagtaaaac accaagaagc aagttgtgga ggaaagggct tattcgtctt 101220

acactttcac actgctgctc atcaccaaaa gaagtcagca ctggaacaca cagggcagga 101280

gcctagaggc aggaactgat gcagaggcca aagaaagatg ctgtgcactg gattgcttcc 101340

tctggtttgc ttagcatgct ttcttataga acccaaggct acctgggccc tccccctctt 101400

gatcactaat tgagaaaatg ccttacagct ggatctcatg gaggcattgc ctcaactgaa 101460

gctcctttct ctgtgatatc tctagcttgt gtcaagttga cacacaaaac cagctagtat 101520

gctcagtttg tagggtgcat acctagcatg cagggagtca tcagttcagt tctcttagct 101580

ttgtgggtcc aaggactgaa ctcaggccat taggcatgat gcaagtgcct ttacagaccc 101640

agccatcaga cccgatgttt ttaatgcttt cagatagcac ccaggtgggt gtactagcac 101700

acatctggaa tcttaagaat cttcagcctc acttaagaag ctgaggctga agaactcctg 101760

catttgacat cagcctcact gatgtagctt gtgtttcgat ttcttgcctg ttgctgtgac 101820

aaactccctg accaacagca aaagaacatg acttttattt gaaaacaaga accctctgaa 101880

gctcacttgc aatgtcactg ccaaatatag aaactgaaca aagggtagaa agcagcagca 101940

ttttcccgaa aatcactgat agggaagaga aacccatcca cccatgagga gaaaaggggc 102000

cactcatgag tcactcagaa tctggaaggg actgaaagaa ccctccctgg ggcctgacaa 102060

ggaagcctca tacattgtgt gctacctaag agtgcctgca ccatcttgta gcacacctgc 102120

tctgtgccat tttggatccc acccttagat tcaacccaac ctgcaccatc ttagatctga 102180

tccaccctgg gtcatcttgg atgtcattca ctctgggcca tcctgggtct aatactctac 102240

caaacaagct cccagtgctc taccctctga gctagaagaa ctctactcaa tgagtcacaa 102300

atactcaact acaagcactc tacctactga gccccatccc tagccccata tccaaccttt 102360

gactgcccat gtttcctttc atttattttt ctgtatttct acctgttagg agcagattcc 102420

ttgccaccat gaatcctttg tgctgtgtct gaggcagttt cacttcagtt atcagtgaca 102480

gttggttttt aacaaaccag ctctgcctgt cagagtttga ggtgccaata aataatgcac 102540

agggtcatga ccttttttca ggccaaagca catgctgctt tcaggtgcat gtgcaagtgc 102600

tgtgaccccc cccagctcca ccctctgagg ccctgaagcc atgtgatcag caatcatcaa 102660

gcccatgatg tcagcagagc acccaattca agaggcctga gtccacaaga ttgtggggac 102720

taagtgatgg ctatgtggga acaaaacaag actgcagaga gcaaagcatg aaaaaagaga 102780

cccactatgt gatgaggggg aggagaaatc acagtcacag tggagcagcc ctagatactg 102840

agtctgcagc actccctggg tgctctgcct gacatcaccc tgggtttctg gaggatgata 102900

cctgttaggg caatggcaga ccctagggtg agtggtaatg tgcacatgca gaagaaggtg 102960

ggcagaggag cacactggaa caattctggc catcctcctg ccttaggcac atgtatatat 103020

gcttcatgtg ggcttagaga ttcgaactca gatcctaatt gctagagcac ccattctcat 103080

agagtatctg tctcatcaga agatcaatgt ttgcagagtt gaataaatgc tttttgttgt 103140

tgagatgttt accaaagact gcatggacat gggtttgagg caatagaaat tctttattag 103200

ccagccagag actacatttg ggtacttggg ttccaagtgt accctaagcc tttctcaggg 103260

tgagctttta aaacagaaac tatgttctag gttgacatgt tttaacaaga acaattagcc 103320

agaagtggaa ctacagaaac caaaatgcaa gcttagtaga tttagaaact ttcccagaac 103380

taagggcttt gatggactag tcttttagtt ttggtaggtg gcgctgtctt cattttgagt 103440

gttataacct gaatgatact tccatcatgg agtcagctgt ataaagtctg ggggtctact 103500

aaggtctggg atcaggctac agttttgtca tagtgtaacc aaactcaaaa taatagcagg 103560

ctctgtgcat tctgactagt ggagtatcag gtcctagcat gtgtttattg aatgagaaaa 103620

tgttctcaat gtgaaacaat aaaaaaaaat aataataaat aaagcagcca gcagactttc 103680

ttgttgccaa ggtcagtgta cttgccacct acgggcatca tcggggcaac tggttccgaa 103740

tggatggtcc ccacttcatt cctgacttgg ggccctattg gccctgtgtc ttctaggacc 103800

cagtgcctca aagctaggag cggtgcagtg cagtgagcat gcactgagca gccgggagac 103860

cacattcttt gcattccagg ctcagggaaa caccgccctc accttgcagg tggtggctgc 103920

ggtctgtgaa gcacccagtt ctcagcactg cctacgagcc caggcctgtt tgaagccgca 103980

taacaagtcc ctggaaaccc ggtctactca ggagccccag ggctcaggat cagcaggtgc 104040

tgcagggcca ctgagagccc gggctttcgg gagggcggca ctcggggact acagaacacc 104100

aggagttcaa tcccctgaga ttaaggagaa accgagaaac cctgcccaac ccggactcct 104160

tctggtgcct ttacccactg ctaaggctct gctggtaaat atccaagcag cagccggaag 104220

ttcctgcacc tcttccttcc cgcttcctgc caagggggag gaaccaggca tgcggtgtgt 104280

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgagaga gagagagaga 104340

gagagagaga gagacccatg gtgtgcgtgc gtgtgtgtgt gtcaagctgg accccgtggc 104400

cccagtgcag ccccctccat tacttttact ttggtgcagg tacatcccat gggcgtgggc 104460

cccgcgggtg agtaacaata ggcagggttg ggccaacgcc gggctcctcc ccgtcggtta 104520

cgcaacaagg cggagcgaga tgaaggctct tccccctcgc gtcatccaga caccccactc 104580

ccccgccgtc acaagccggt cgccgcccag ccggcttccg ccgggaatga agagggttgc 104640

ggttggctcc ggtcccgcgg accccacgcg cgtccgtgga gccctcgggc gacttccatg 104700

agcccctccc atcgctctga gacccgctga gtttgcttcc attgtcctct cggccgcggg 104760

ctccggaaca cccgtgcgag cccactgctg atgcacagac tgccattgcg ccgctgtcac 104820

accgtgcgtc ccccgcccca tggagccgcc cgctggtgcc gcggcgaccg taaaagatcc 104880

agaccatgac cccgtgaaga ccaaggtctc ggcgcccgcc gcggacccca aacccaggac 104940

atcgtcacag aaggcggggc actcgttaca agattgggac accatagcca ccgtgggtga 105000

gtgagaactg agtaagaact tatgtgtggg gacgcggctt gggagcgacc ctcagatttc 105060

tgtctcccac actctcatta ctgggcctcc ggaaacgggg cagccccacg tcacagagct 105120

ttcaggaggg tgacttcacc ttagggactc ggaggctccc tactggggtg ctagccaccc 105180

ttgggacacc acgcccggcc tccctggcgc ttgcgcaccc gctcatgccc aggatttctc 105240

gggatcgcat ccagcctccg cactgtagac ccctggcggg actcgaaggg acgcgtgacc 105300

cccaagggac ccttcgggga cgttttccca gcatctattg tgtgcctggg tctcgttttt 105360

tctttagtgg ctcaaacttg gtaccctcgt gaccccgaaa gttgctaggg aagccggtag 105420

atccccaaac gtgccggagt actggggagg gaggctagga tcttgcgaat catgggcgcc 105480

agcttctcaa gtctgaagcc caggagtccc gggcttctca gcaaacttgg tcactaggac 105540

agttgtgcct ggtgtgttga tgattaggaa agtgttccgg gaggatggag gaaggacaga 105600

gggagggatt ggcgtcctcc gatcagctgt gagcagagat tctagaggct tctgtgttca 105660

ccctggtgtg gaagtcaagt cagggttcag gaccaggatg aggggcaata aacactttct 105720

cagctgagca ggtgagatgt taaaaaaaaa atgtgtgtgg gtaaaagggc ttgcaagttt 105780

gatcctggtt ccctcttgga ggctggctga cactcgctgc atcttggctt ttgattgact 105840

tttgagggaa actgagctgc ttgaatgaat gtcgtttatt tatgtatcat gttgtattct 105900

aggctggcct ttccatcact gtgtagccag gatgacctta aactacacat tctccgcctc 105960

cccctctttc tgagtgctgg gaaccgagcc ccactccacc acagattggt tatggggtgc 106020

tgggaatggg gactgccctc tatatgtttg agacattgac ctgaaagtca ctgcatagcc 106080

taagctgact ggagatgcca gacaatcctc ctgtcttagc tttcccagtg ctgagacttc 106140

agggactcat tcacaggcac ttggcacctc aactggttct ccaccctttt ctttctgtct 106200

gtcttccttg ccctctccct ccacgcccca tctcggcacc ttagctggtt cttctctcct 106260

tccttccttt tttctttcct tcttcttcgt ccttttttgt gtttgtttgt ttgtttgtct 106320

gtttgtttgt ttttgaaaac aaggactctc tccatagctc tgggtcacta actcctagag 106380

atgtgcctgc ctctgcctcc caaaatgtta ggattaaata tctgtgccac cacacctggc 106440

tcttttgtta attttaaaat ttacttattt actgtgtgaa cgaggggagg gggcagcaca 106500

agtgtggggt caaggttcaa cttttagaag tctgttgttt tgccaagtaa gtccatggta 106560

tcaaactgaa gtccttagac ttggcaacaa gcctattggt ctgctgagcc ctcttactgc 106620

cccactgtgt ccctagaata gacctcatgg gacatcttgg gagcgtcctt gtcctgaagt 106680

cctccaactt cttcaccttt tccttaccat gaccctgttc cctcggaatc ttttagaagg 106740

acctgggcac acacatcagc ctcccctctc ccctactcat cctttcatat atatacacac 106800

ataactgagc tataagcgct ctcttcactg agccctcaca taaatttaga tggtgtctat 106860

gaccaacgga gttttgtggg tgtttgagac agggcctcca tgtgtagctc tggctgtcca 106920

ggtacttgct gtgtagacca ggtcttgaac tgcaggtgcc taacaagtac ataccaccca 106980

aattaacatg gagcacctcc gtactctctc tctctctctc tctctctctc tctctctcac 107040

acacacacac acacacatac acatactcac acacaaagac aactcctgcg tccctagtcc 107100

ccagcacaca ctgcgttctc caggaaataa gtgttgatgc ttttgtctct gacctaaagc 107160

tcatttctcc attcattagg agactcaagt agagaacatt tcaggctggg gatgtgattc 107220

agtggataca gtgtttatag cttagttgag ataatgttta tagcttagtt gggatgggga 107280

gactgcttgt gattacagta catgtgactc agtagacaga gtatttatag ctcagtgggt 107340

agagtgcttg tagctcagta caatgcttgc attcagtggg tagaattaag tgggtagagt 107400

gcctgtagct cagtggacag agtgcttgta attcagtgaa tctcatatct aaatttgctg 107460

aacaggcccc ctctgtccag caggtctaat gtagtcttgt ttccctgtac tcagctgtga 107520

tctcttgagt cctgtgcctc agtttacttt tcagtgcttc catggcctgc tgccttatgg 107580

aaagccagta ctaaatcttc agtcttacaa gggcagaaga tctccagtct gtctggatgg 107640

gaacatcctc cttagatgaa gagtcacatg agcagctgtc agatgctctg acagatcact 107700

acaggctagt gtcttttaca ctagagagga attactgagg gtcctgtggg ggatggggga 107760

gttggcatct gagatacatt gaggccatct ggtagtccat agtgacatta atacaaattt 107820

agaactatct aggagacact tgaagtccag atcattgagg aagaagaatc ctgtgcatgg 107880

gtggggaccc agagtgctta aaagggaaat caattaccca ttaatattgc caagtcacca 107940

gcgttcatcc ctattgatgt aaggagagca actatgtcct gcttttgcct ccatgaagtc 108000

atctcccctg gaaggcccac tctcaccacc atacaaccct agtcattagt aatggtgtag 108060

gctgtgggag ttgcattaac attcatgaat atgcagatat acactctgta tatacacacc 108120

cacattgtac aaggccagcc tctgcctctt tctagaccag tcccattgtg cagaggagag 108180

attgtaatca cccatagtac acttggctgt tcttttgcaa agtccctaaa ggtggaatgc 108240

tgtgcacaat gcctcccacc atgtcatcac ttccctgagt gctaccttct aattcattgt 108300

ggtttatgag atggggcttc actgtcattc aaaccaggca tccactccaa ccgaaactaa 108360

aggatcatgg gttggaggga tatgaccaca ggatgtctgg aacacccaga agcaggacat 108420

ggttgggagg gtcttctttg aggcctgcag gagatgggga gtagggggct gatggacctg 108480

tacctcatat ttccaccctt ggacaaagga taacaggtga gcctacccac tttgtgccac 108540

cttggatgtc ttctgttcta tgtcatcctg actgaaccta tctgggccat cttgaacccc 108600

acccaccctg agccatctta aattccacct aacctgtgcc attttgcctt gaagctatgt 108660

atgctatctt gaatagcacg taacctttgc catttgaatg ccacccaccc tggaccttct 108720

taactaaacc atctagaaac ccatccaagg cagccatctt gaattgctca ctgtcttgat 108780

atattctttc aggtttcttt tcttgactgt tttctcctga tagtataaag aacctgtcct 108840

gtcctccttc tcaaccccta aaccttgtct gtgtatctgt ccatttcctg ctcagccctt 108900

agcatcctca tcctgaatca ccaagggtga taaatcacac tctctctctc tctctctctc 108960

tctctctctc tctctctctc tccctccctc cctccctccc tccctccctc ccccatgccc 109020

cctgcccctg ccccctctcc cctctcccct ctccctctcc ctctccctct ccctctccct 109080

ctctctctcc ctctgaaagg cacttgtcct gagccactgg tggtcctaga gtgagtttca 109140

ggatgatttt cctacaagga catcacccaa aaggagagca ggaagtcaca gcttcagtca 109200

cgcaggccaa agcttcttgc ttcaatctcg tttagagcct ggatgctcta gtcttagtct 109260

aaccacacac taaggacagc accttcattc tcttgaggac ttatgcatcc ttaggcgttc 109320

tctgtattga cattttcatt taattttatt tttgaagtgc tgggtgttga atatagagcc 109380

tcactcacat taagaaaatc tcctagtctc tcttaagtct cctctgtcct ccctttttct 109440

ttccagagtc tcccagagta gctcaagctt tcctggaact cactgtgtat tccaggctgc 109500

cctcaaaccg ctgttaatcc ttctgcctta ctttagaagt gctaggatta aagcctaccc 109560

tactaggctg aatttatgca aagcttggga ttgtgtcctg ggcttcatgc atactacact 109620

taaatatcct acttttagtt ttatttccta tctgaaataa ccaccatgcc atcacacttc 109680

ctttatttta aaaagatttc tccctgaggc tgagggtgga actcagtgat acagagcttg 109740

taattctgtt gatagggtgc ttatggctta gtagattggc tcttcctgtg ggaggccatc 109800

caagctaatg acacactgct gtacctgata cttggctcct tcaggaatta tctgggttgt 109860

gtttccagtc cactcttctg tttatatttt cctttccaag gctagggtta gaatgtgagg 109920

ggaatagtaa taataatagc cacagtaata acccacttat tattattata tctattattt 109980

ggggggttgg actggaaccc agtgcctcat gcatgctagg taaccagcca ctgagctgct 110040

acacacagag cccaagagca aacttgttag tagtagtatc atcacttttt ttttgtttct 110100

tacatttatt ttattgcata ttgttagtaa atattccatt taatacaatt atgttgtcaa 110160

aataaagcaa gaaatagtgc tatgactcat tgttgacata taccacaaat gataacataa 110220

aactccagta taagagaaac acacacacaa tatatatata tatatatata tatatgtata 110280

tccagtgttc taattttatg tacagtttta agtgggggta aattttaaac atttctattt 110340

tttccaattt ttttattgga ttgttattgc tcttattgtt gctgtgtgag gtgctgggaa 110400

tgcaaccaag gaactcattt atgccagtcc tgagttccag cgctgagttg catccctagc 110460

ccatccttcc tgcctctata tcaaatgctg tattgacctt ggacaaaaat cacaatttcc 110520

caatatgatg gggaaaagga aaggacctgc atctatcttc acagcctgct gcaattgttc 110580

ctgcttgtgc atgttggatt ttgaaaccca gttctgggta tctgggcgac ttccatgtaa 110640

catcttcctc agctacccca ggagccttgt tacccacata aaagtttaca tttcctcctc 110700

accatgtcag acacagaaaa ttatgtctga aaggttacag gtgttcatgt atggaacact 110760

tgactaccat ttgtagagca tgtgtgtaga ttagatcttc ctctgaggta gtcatttggg 110820

gtttttgttg ttgttgtttg tttgtcttat tggcaaaggc attcatcctt gtggaaggca 110880

accttggaat ctataagggc tgtaaagtaa tttgcaatga atttaggtgg tgttgtttgt 110940

taccttgatg acctgtgacc tctgagtcac cttataggtc aagggactct gctgtagtga 111000

ctgttgtaaa tggctggggt atgagcatca aagatggagt gattttgtat cacataggga 111060

tgctgggaca ttgactggga taggcatata caacatacat ttgagtgaat gtaggttgtg 111120

ttgatggctt acaaccaagg gattgggggt ggaggaggag gagagacaag caacttaggt 111180

ttgggtccaa tgacaacaca attctttctt acagactttg aatattggtg tggaatgtgt 111240

attagctagc ttcccattgc agtgacaaga tctctgacat tataaaatta taaagaagaa 111300

tgatttgtgg tggcttgtgc tgtcaggcat ccatccatgg ctctgttggt ttggacctgt 111360

ggagatttag agcatcatgg gagcttgtag tagaacagag ctgcttacca cgtagtggcc 111420

agtacacata gaaaagagaa gatgagtccc agtgtctcct tcaatgtcat gcccccaatg 111480

agctaagttt ctcccactag gcagtaaata gcaccttacc ctgagacttt ctggtccttt 111540

tgcttgactt tgttctgaca gcttctggca gttggcactc tgctgtactg ttcttttcca 111600

cagtgttagg tttctctctc agcctgtgct ctgctctgtg taatcaacac caccagctgt 111660

ttctgcaccc acaagtctca ggcacaagtg tgaaggaaac aagtcggtag ccatctgata 111720

cagaagtcat cctgtggact gcgcatcgca gtacagctgt cacaggctct cttcacctac 111780

tgtactttga acacaaaggt gacatgtgat ccaccaatca gaagcacagg caagggttcc 111840

agtgtcaaga cccttgcttt tctcattttg ctgtgacaaa atgcctgata ataggaattt 111900

aaggggagag gggattattc tgactcagac tgctgctggt ccatcatgga ggcaggagca 111960

aagagaagga atgctggggc tcagcttact ttctggatcc aggaccccag caaagggatg 112020

gtgatgccca tattcagggt aggatttcct acatcagtga actagatgtt ctggggtagc 112080

ttggagcaaa ctgaggttat tttaagcatt ttcagcttga ttatcccgtt cctcattgaa 112140

atgtctataa attctcaccc acactttcta tccatctgat ccactgtagg ccagtcttgg 112200

cttccactca ggctatgact ctgtgtccct cctccattcc tatgtattct gtggcaggtg 112260

tctcctgact gatagacatc accttttctt taaagaacaa aacaaaacaa aaaaccaaca 112320

aaccccaaaa atccctaagc acccaagacc aattttatat cccaattaat tcattgtaag 112380

cttagatagc agaagtaaaa gaatgttttt tgaggctggg catgacagag gatgcctgtt 112440

gtccctttta aataacttta gtactaaaca tggttttttt gtggttattg ggctgttcgg 112500

cctgctgtct agctgtgggt gtgtccttct tgatcctgca tctggatcta gcttgctgtg 112560

gggagcattc tgtatttttt ccccttttta ttggatattt tctttatgta tgtttcaaac 112620

gttatcccct ttcctggtcc cccctcctgc aaaacccctg tcccatttcc cccttcctct 112680

gattctgtga gggtgttcct ccacccaaac acccacctta ccgccttcac actccctata 112740

ctggggcacc tagccttcac aggaccaagg acctctcctc ccattgatat ctgacaaggc 112800

catcctctgc tacatatgca gctagagcca tgagtccctc catgcatact ctttggttgg 112860

tagtttagtc cctgggagct caggcagtgg aggcttctgg ttggttgata ttgttgttct 112920

tcctgtgagg ttgcaaaccc ctttagctcc ttcagtcctt tctctaactc ctccattgga 112980

gaccctttgc tcagtctaat ggttggtttt gagcatccgc ctctgtattt gtcaggttct 113040

ggcagggcct ctcaggagac agctatatca agctcctttc agcaagcact tcttgtcatc 113100

ctcaatagta tctgggtttg gtgactgtat atgggatgga tccccaggtg gggcagtctg 113160

ctccacactt tgtctccata tttgttctgt gagtattttg tttccccttc taagaaggac 113220

cgaagcatcc acactttggt cttccttctt cttgagcttc atgtgctctg tgaactataa 113280

cttgggtatt ccgagctttt gggctaatat tcacttatca gtgagtgcat attttttaat 113340

ggtgagaaaa gaatgaaatt gtatgaggtt tgcatttttt ttggagtaca tcataagatg 113400

tccttttcta catcataaga cagaaagcaa ctgtgtttaa aggctgggat ggggagagag 113460

gtgggggatg gatgaaggaa tgggggaatg gatgttggtg cgtgagggtg gatgagttag 113520

tatatagatt gaaatggaag agaaagagta agaggaaaag aggacaagat ggatatggag 113580

ctagaagaga aaaggaacac agggggcata gggagagata cagatggagg aagatgaaga 113640

ataattagga ggaaaatagg gaagagatga tgaaagggca gatgaggcag aaagttcagt 113700

ggaggaaaaa aaggaggagg agcagagaga ttcagaaaga gaagaagcag gaagtcttgg 113760

aagaagagga ggggaggggg taggagacaa tagaggcaga tagaggtgga agaggaaggc 113820

agacagagag agcaaggatt caaagttccc caccaggagt caccaagtcc agcatttcag 113880

ctcttcccat ggctgtgttt caatctccaa tgcacatagc aggcaattat ttgttttagg 113940

ttttagtcat tattattact gtgcatattt gtggttgtag gcaatagcat gcttgtggac 114000

agacatcaca ggaaactttg ttgagtgact gtccattcat tccccaaagc aagctcttta 114060

ccctcagagc catctccctg gccccttgat tgacagttgt gtgtgaaaaa atatctatac 114120

agagctcaag tgctcatcta agtttctttt cttgtattta tctttaaggc cccagattgg 114180

catgatgtcc attcctcagg tatgtttcct tttcctgatc cttgactgaa tgcattgtct 114240

tcctcaggca ctgggacctt tggccgtgta aacctggtga aggagaagac aggcaggcaa 114300

tactgtgcct tgaagattat gagtatccca gatgtcatcc gcctgaaaca ggaacagcat 114360

gtgcagaatg agaaagcagt cctgaaggaa ataaaccatc ccttcctcat taaactgtga 114420

gttcctggct ccttcctttc cacctcctca cctccctaac gttattctcc caagagtgcg 114480

atgtaggggt gctgccaggg ctgtagctca gtggatagag tgcttttagc tcagtggata 114540

gagtgtttgc agctcaattg gtagagtgct tgcaactcag ctaatacagt gcttgtagct 114600

tagagggaag agtacttata tatagctcac cttatggaac gcttgcagct caattgttag 114660

agtgcttata gctcagtggg taaagtgctt gcagctcagc taatacagtg tgtgagtagc 114720

ttagtgggaa gagtgcttgc agagcagtga taagagagta tgtagctcag tggatagagt 114780

gcttgtagct cagtggtgtg aggtgggaga tactatccag attttgtctt gatttattat 114840

tgtgtgtgac catgcacatg ggcacagtac cacacaaagg ccacaggaga gcactatatt 114900

tccttggaac tttagttaca ggtggttgtg cactgctcaa ttgggtgctt ggaatccaat 114960

ttacatcttt aagagcagca agtgttctta aattctggtc catacctcaa cccttaactt 115020

aggagttttt ataacaacta ctttttgtgt gacctgacca ggagccatga ttctaacagt 115080

ctcttcaatg tttatgccca aacattgctt atgttatgta aaagtccaag acctgggtct 115140

tttattacgg cttctagtca aggtgacaga gtaagctaat tattcatttg atattcatat 115200

aaagcaactg gtgatttttt taacaatatt aaatccctct ttgaatttga gaaatataga 115260

tgtatataaa aatacttata tacatatata gtatgtgaag gtccatatgg gcgtatgcat 115320

gtggagatct gagaacatct gctgtcattc cttaatttaa agtgtttgag acaaggcttc 115380

ctgatagccc aggacacaga aagtccaggg agcttcaggg agggtaaatt acccagcatg 115440

tcgttattga aacaccactg cacaattgtc atgctattct agagtattct atgttgtcag 115500

aacattacat aagtgcacta tagtcaaaat tcattagata gtgtagaaac tagagcatcg 115560

ggctgaagga gaaggatcag gttgagtact tgttcctttt gcagagcacc tgggtttggt 115620

tcccagcact cacagcgcac agtcatctgt aattctaatt tggggacaca tacacacaaa 115680

taaatatgta aataagatac aaataaatat gtatttttaa tatttgaaac acagggcatt 115740

taaattctac acagacttca atattagcca aaatatgttc ctgttagcca cagcaccaac 115800

tgaggctcat cgctctgtga gtgtttgtgt cccagtctcc tctccttatg aggacccagt 115860

cctgttaggt catgtctacc ccaaagacct cattctaccc cagtttcccc atttaaagat 115920

ccatctccac acagctctgt cccaaggtcc taggtatgca gacatttaat acaggaattc 115980

tggcagaaag aatcctgagt gcttagctaa gtcagactgg acaattctac ccaccactgt 116040

gtaattacac atgccttaaa ggaatctttt cttttttgct ttctttatct tgcatttaca 116100

ggattcagca ggtgggttaa aaactatgtc aaagtgactt agtgctatag agatttgcac 116160

ttggcctgca tgctgtattc acagcatggc agagcacact gtatatctgt ccagctgtag 116220

gaacacaact tagcaggtct ttgaacttca aaggatgata tgcatgctac ttaaggcctt 116280

taaagtctta tactctgtcc tttaactgtg aacacttgtg aggtcatcca tccaacttgt 116340

gcatgttgcc tatgaacatg gagtagtctg tcttgaggaa acatgggatg cccagcatag 116400

tgggaaaggc ttcaaacggc tgatgaaaat cacagcttac attgctgcag aaatctggac 116460

ttatttacaa atggttttaa caagagtcag tattaggctc agcctactgt acatggcact 116520

attcccagga cagggaaaaa tgtgtgataa gcttcaacta tcaattggca caacccaaaa 116580

tcccctggga atggtttcac tgagggattt cccacatcag tccagcttgt gaatatgtct 116640

gtgagagtgt tctaattgat gattgacata ggactccacc caccatggac aagatgaggg 116700

tgtagtgtca atttgacaca gaaagtttgt gctctacatg cataccatga cccttcatct 116760

gtgctttcat tcctttatgt cagaggtatt tgcacataga ggtataacaa gaaatgaagt 116820

cttgactggg ctgcactgtg cactcttgaa aggtccagtg cctttgggtg ccctactgtg 116880

ggtgctgaga gaagaaacct ctcatcctag gggcttataa tcagagtgct ctttagacat 116940

tgctttgtac ccctggagag caatgatgtt tctggatgaa aaccttgtgg tagttgggtg 117000

ggaattactt gcatgatata tgatagatag atagatagat agattagata gatagataga 117060

tagatagata gatagataga tggatggatg gatggatgga tggatggatg gatagatagt 117120

atatgtagat gatagcagat agatgtacgt agataacata gatgatagat catgaatgga 117180

aggacaatag atggtagaaa ggtgatagat ggttggatag ataggttaaa tagctagata 117240

atagatgact gactgataga taatgataac atacatacat acatacatag tattgacggt 117300

aatattgaag gtctcaccta gggcaccatc tcttagcata tactctcctt gtgaattcca 117360

ccctcaggtt gtcaccacag ttttagcatc ctctgatatt ctaatatcaa cctgcatcta 117420

cagtccagct aagcacaacc ttatgatctg ggttgactga catcagatat cttatcaaac 117480

atcttgatta cttgctggtg agctttgatt ctgttgtgat taaacaatga ctaagaggga 117540

ctgagggtag gaaaggctta acttggctac ttggctttca ctttgctgtc acaggccatc 117600

tgagaggaaa gtcagagcag gaaccagaag cataaagctt tcatccagcc caagaaccca 117660

gtccatgatg ggtggggctt cctatgtcaa ttatcaaaca ggacactccc cacagacacc 117720

cacaggccaa tctaatgtga gaaatgactc actgagaccc tacctaggtg acttcaagct 117780

gtgttagagc tgacagcaca tcttccccct gctagggact ggcgccaccc tccatggaga 117840

tgatcgtcat acttcaatca actaatcagc tgaataaaga catcccccca tagacatgcc 117900

cacaggctag gatgatatgg gaaattcttc actgagtacc ttcccaagtg actctgggtc 117960

ataaaggtga tggttaaagc taaccaggac acattcacat gtttgcatct gtttatgtgt 118020

ttatcttgat atctgtattt atattttgat atttgcatat atgcacctgt tagtgtctgt 118080

gtataccagt atattaatgg gaacatctac ctctgtatat ctggagtctg tacacatatc 118140

ttgtcatcag tgtctgtcaa tcaccaacat acatccatcc atgagtatcc acttctgagc 118200

acccaactta ttacccatcg tgcactctgt tgtgtctcgc aggctttgga caggccatga 118260

caaccgcttc ctatacatgt tgatggagtt cgtgcctggt ggtgagctct tcacctacct 118320

gcgtaatcgt ggccgattct cctcagttgc ttcagtcttc tacgccacag agattgtgtg 118380

tgccatagaa tatctacact caaaggaaat cgtatacagg gacctgaagc ctgaaaacat 118440

ccttctagac agggaaggac atattaaact gacagacttc ggcttcgcca agaaactggt 118500

ggataggtga gtgggaacag ccattggctc atcagaggtt aattaaaaaa taaaggtttg 118560

atttaaatgg gtggacagaa aggggcagaa gatgtatggt gggctctggt gtgatgcact 118620

tctccctcca tctatttaga tgggtctccc atttttcccc cattggtata gtaataaaac 118680

catctttaaa aagcagatta aggaagaaca gggataaagg tgccaacagg agcatgtgta 118740

gaggacagct gtttacattg tagccacata taggaagagc aagcaggaag tagagcaggg 118800

ttattgtctt agttagggtt ttactgatat gaacagatac catgaacaag gcaagtctta 118860

taaggacaac atttaattgg ggctggctta ctggttcaga ggttcagtcc attatcatca 118920

gggcaggagc atggcagcat acatgcaggc atggtgcagg aggaactgaa aagttctaca 118980

tgtttggctg aaggcttctg gaagactggc tttaggacat ctaggatgag agtctcaaag 119040

cccaatacca gagtggcaca cctactccag tagtgcccct ccctgggcca agcatataca 119100

aaccatcaca ttctactccc tggcccccat aggcttgttc aaacatgagt catccacggg 119160

ggccatgcct aaacatagca tattaaaaaa atacatttag tccaacttcc aagtccccac 119220

agtctatagc agtctcaata atgctaaaag tccaaagttc aaagtctcat ctgagattca 119280

cccaatcaat taactgtaat ccccaaatca aggcaggaaa ccagctgggc aaactcaaac 119340

tctgaattcc catgtctgat gtcaaaggag tcttcagatc tccagctcct ttttcatcat 119400

tgttgactgt aacaaatttc tttgcctggg ctggttccac tcccttttag caactttcct 119460

caacatgtat cccatgaccc tggcatcttt aacatcttgg ggtctccaag tcaacttcag 119520

cttcacagct tcttgttcca gtgtctggga tctacacatg atcttctggg ctcctccaaa 119580

ggacttgcat tgccacaggt ccttcattcc cgctgcaaca ggaacttcat ggacaccaag 119640

tcgggttcac acaatgactt ctttacttgt ggctttttcc tttacagctc tcttccccag 119700

cagcttcttc ttagggcaag ggctaaacta caactcctat tacaatagct tctcttactc 119760

ctacttctac tcacagcaag ggctaaacta tattcaaacc gactcacctc cttctagctc 119820

caccccacct catccaatca gaattcacac acgctctagg catgagctca gatcgttcac 119880

agataggctg acaggtcctg atcacaaggg atagtctagc ctggcaggca gcccacgcat 119940

gcagcctcac tgcacatgct cgggcaaggc agtaaacaac ttggcccatg cagccacatc 120000

tgcttcccgc gtcgcatcac ttcttcaact ctgccctcta tagcactata gtctctggtt 120060

gactccactc cactgctgct gccattcttg gtactgacat cttaaatatg ctggcatctt 120120

ccacagcaac taggcttcac caatagcctc tcataggctc tcttcatggt gccaggcctc 120180

aactttgcat ggccccctca gtcccaggcc atcaactata actgagactg caccttcacc 120240

aatggctccc catggcctct cacagtgcta agcctcagct gctctccatg gccccttcat 120300

accttcaaaa ccagtaccac ttgggtgatt cttatgcatt atcaagtcca gctgcaacat 120360

gacatacaac ctcggctatc tctggaacac agcttctttg tgctttcaga aaatacttct 120420

cagaagattt cacttcaatg atgctggtct taatcactgc taatatctta gctccagcta 120480

accagcaaca attgttcctg tagtcccttt tattcttgac tctgaagcta gagccacatg 120540

gttgaaactg ccaaattctg cagcttgcta gtgccggaac attctgccca cttattctat 120600

tagcagcttt ctattttcca actccctcaa ggcttggctg tccttgaact tgcactgtag 120660

attgaccttg aactcagaga tctgcatggc tctgtctcct gaatgcccct ccagattgtg 120720

agcagaagag aaaattgttc tgccatcaag atggttgaat atgttccaga aaattccaat 120780

attgtatgtg tgaatgtttt cataattgca tatagataga tatatagatt acttatatca 120840

tcatataatt tatatatcta tataatccta ccattcctgt acttaagctt ttcttcacct 120900

agaacttgct ctgtaccagg ctggccttga acttagaact gcttgacttt ttctcctggg 120960

attaaaagta tgtaccagca tgcctgggcc taagcttttc atagccactg tttctcaaga 121020

tccagatcaa aagcctgtgt cttctagcct caagatctgg atcacaagtg tacccttcat 121080

ttctagattg tagtttattc cagattaaaa gtccacacta ttccttgttt aactgcaaac 121140

acaagcagta ggtttagcta ggtgggttct tgcagtgaga ttaccactcc ctgaatgtct 121200

ttatctcctt gaacaccgga ttcagctcca tttcacttcc tggagtccct ttataacttg 121260

gaccatacat tttatatttt tcctttctca gcttgtttct cttgttcaaa acacccttcc 121320

tgagacttaa tcagagaaca aagtttctgt tgggcttttt gagacttcct ttgtcaatgc 121380

aattaatata aatctcttta cgttaacctc aggtagacgc ttcaggcaag ggcaaaaagc 121440

agccccattc ttcaccaaaa tatcacaagt ctctcagcca catattaaaa ttgttctcct 121500

ctgaaatctc tataaccagg cttccacagt tcaaatcact cacagcaata acatcttcca 121560

tattcctacc aggatggccc attgagcccc acataaagca ttccagtgct ttccaaatac 121620

aaagtcccca aatccacatt cttccaaacg aaggcatggt cagacctatc acagtaatat 121680

gccagtccct gataccaact tctgtcttat tactgctata aacagaccaa ggcaactctt 121740

ttaaaaacat ttattggggc tggcttacac gatcagaggt tcagtacatt atcaaggtgg 121800

aagcatgaca gcatctaggc aggcatggtg caggcagagc tgaaagttct acctcttcat 121860

ctgaaggctg ctagaagact ggctttcgga catccaggat gagggtctca aagcctatgt 121920

ccacagtgac acacctactc aaacaagggc acaaatactc cagcatttcc actccctggg 121980

ccaagcacat atagaccatc acatttaaaa aaaaaaacct tgagccccac tgctactgac 122040

atactttctc ctgtgaggct ccactttacc taaagcttat ccagaacttt cccaaacaga 122100

gctgcctgct ggaccaagtg ttaaaatacc tgagcctgtg ggggacagcc cacacctagt 122160

gtacagctat gggagtggag aggcccctcc agattgtgag cagaagagaa aattgttctg 122220

ccatcaagat ggttgaatat gttccagaaa attccaatat tgtgtgtgtg aatgttttca 122280

taattgcata tagatagata tatagattac ttatatcatc atataattta tatatctata 122340

tacatttata tataactata ttatatatat ttgtatattt tacacacagt aatatgctca 122400

gggatactat agctggatca catggcagtt caattttttt agtgttgtat ttttccccat 122460

aagatacatt tattttatgt ctctatggtg tgcctatatg catgtcatac ccacagaggc 122520

cataagaggg catcagatac cctagacctg gagttacagg tgaatgtgtg cagtcttatg 122580

ggtactaggt gttgaaccca ggttctctgc aagggcagcc agcaatctta aagctaacat 122640

gcctctccag cctctgtctt agagttttct atttatagaa ctcagtcctt agggtccttt 122700

gcccagggct ccttccccta ttcatagcta tggaagttct ttactgataa tgaagaagat 122760

ggtgtcatgt tcctgttaac ccatagccgg ggtagggggg gaaaggctca atattgaggg 122820

aatcagatac tttccagcct caaagggtgt ccatgctgtg tacagattct ctatgatccc 122880

agtattgctg tggtgtgcta agtaccctta accagccagc cagccattgg tgcattttgt 122940

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa agaatgtgtg cagaaaggtt caaagctata 123000

ggaacaagcc agaactagaa aattccacag cctgaggcat gcaggcctcc agcctggggc 123060

agacacaaaa agactcagct ttcagtgggg taagcagagc tgcctccggt agagttacct 123120

gtgacctcat cagctcatta gctctatctg ccctgatctt gttctgagac aaggctacaa 123180

ggatcaaaat ctgagttatt gggcccaggg gcaaatggaa tgttgggagc ctgtgatgga 123240

ctgacttcta gttgatttcc attacggaga gaagagagga ggcagagggt gtatgtgcag 123300

cccaggctgt catagcactc actagggagc caaggatgac cttgaactga tccctcctat 123360

ctggacctct ggcgtgctag tatgacaagt aagcatctcc acatcttgtt tatgctgggg 123420

ttgggatctg ggctcagtgc ctacaaggca agcactctgc ccattgagct acaagcattc 123480

tgttcctggt cctaccctat agttctatcc cttctgagtt ggatcagttc tttacaggtt 123540

cttgactcga atccccttct atctgttccc tgtgctgtac tgctcagaag ctcttgagtt 123600

ttgggccctc atctctgtca gttccttcct gagccctaga atccttatta ggaagtcttc 123660

ctgatatgtc cgtctgtggg tatcagggtt ggagcaaaat ggatggaact gagcaatgga 123720

taaattcaag gaaacatgta ggcttgaaat tgtcttaata gaatcagtta tttcttcttt 123780

ctcttctaat tcatatcttt gccccttttc tttttaattg cacagtcttg ccatacagcc 123840

caggcacccc caaatgtcat tatccctttg cctgagtctt ctgcatagtt agattgccag 123900

tgggagcccc agactgagca tagaattttc cttttaaaaa cattacttta ttattttatg 123960

tgtgtgactc ttgtctgcat gtctattatg tctgtaagtc tatgtaacac atgcattcct 124020

ggtgccccca gaggtcacaa gaggccatca ggtcctcctg aaactggagt tagaggtgat 124080

tttatcacca ctatgtggat gcttagaatc aaactcaggt tcccacaaga acaagtgctc 124140

ttattcactg agccatctct tgatcccact ttaaaaaata attacattta tttatcttgg 124200

atgggggaga gtacagttca gaggtcaact ttcagaagtc agtgttctgt taccatgagg 124260

gtcccaggaa ttgaactcgg gttgtcaagc ttgacacaat tgtttgacct gctgagaatc 124320

tctgcttcaa gcatgcttag gcctctctca actttaccat ggtcctagct tcaggacatt 124380

ttgatcatat gtaaacatct ctcctcattt gtgcctcatg accctgtggt atgcctctct 124440

ggatcttcct agcctacata ctttacacac acagcatcat tacaatattt tttttttatt 124500

ttttgttcca gcttatgtaa tggcattgtc tatctatgag gtaccactgt caaacttact 124560

gtccttttca tggctgaata atattccttt ttatagttgg accacatggt gtttattaac 124620

cttgtataac ttaatttact ttttatttga atctttcttt tgaagaaaga aacaatcatt 124680

ttttcctatt ttatctttct ttaaaagaaa caaatcaact tttcattttg tatactctgc 124740

agcttgcagc tgcttgccac accaattggc tcttttaaat ataaattaaa gcaggacaag 124800

gtagcacttg cctttgatac cagatagcat tcaatgggca gaagaaggta gatctctgta 124860

cgtttgaggc tagcctggtc tataagacag ccaaggctac acagagaaac cctgtctcaa 124920

aaaaaaaaaa aaaaatagag ctttttgttc tttcaaatgg gttctttctt taaaattatt 124980

cttttctcct gtgaggacac agtagaaagc ctgaagctat agttttgtgg tagagcagtt 125040

taccaaggat agagcttcat ggtaaaccag ttaggtaatg tataaggccc tgggttccat 125100

ccccaggact gtaggatctg ctggtggaag agtaggatgt agtctccatc ccagcaggga 125160

gagatgggga gaattttttt taaaaagaaa caaacaaaaa tcctagattt gtccaaacat 125220

cctactgtcc ttcatctttc ttgtctgtgg gtggcaccaa aagctaaact caacctccaa 125280

tcctgccaac tgtcctaatt tcttttgaca aaaatgtttc ttgatgaggg attggagaga 125340

gaaattatca acattctgga aatttttctc ttcagaaagg agcttgttgc cacacaagca 125400

ggaagtgctg gcacagcaga gttgatgagg agaggagagg ggtcatatta ttttttattt 125460

ctttgatttt tgacacaagc ccctgatccc accacttggg aggcagaggc aggtggatct 125520

ctgtgagttt gaggccagtt tgagatctat agagcaagtt gcaggacagc ataagtacat 125580

agagagacct tgtctcaaaa tacacaaaaa ctctgaagtc ctgatcctcg tgcctctacc 125640

tccatgctat gctggaaatt gaacccagag tctaaacacc agccatgctg gtaccaacga 125700

tgctgtacca actgagttat atccctagcc cctatcacta atgttaaaaa ttattaatac 125760

tgcatattga tttacccacc catgatggtt tgtatattct tggaccaggg agtggcacct 125820

tttgaaggtg tgaccttgtt ggaattggtg tgacctggtt ggagtaggtt tgtcactgtg 125880

ggtgtgggca taagatcctc accctaggaa agagaggccc attagtcttg caaactttat 125940

atgcctcagt acaggggaac gacagggcca agaagtgcga gtgggtgggt agaggagtgg 126000

gggggggtat ggaggacttt tgggatagca ttggaaatgt aaatgaagaa aatacctaat 126060

aaaagtaaat aaataaataa aataaaagca aaaaaaaaaa agcctcaccc tagttgcctg 126120

gaagtcagtc ttccactagc agcctttgaa tgaagacata gaactctcag ctcctcctgc 126180

accatgcctg cctagatgct gccatgttcc caccttgatg gtaatgaact gaacctctga 126240

atctgtaagc cagacccaat taagtgttgt tttttataag acttgccttg gtcatggtgt 126300

ctgttgagtt ttgtttactt tttaagtgtt tttattttaa gttgtgtatc tctgtgtgta 126360

tgtgtatgcc agtgcagtac tagctgagga caagaaatga tcatgggatc atctattaac 126420

taaattaaat tgaagttaat gcttgtaagt aaagaacatt cagcaaggaa cttgccatta 126480

cagggtcagt ttatgtgata aatatagatg gagcaactag aggtgatggt ctatgcatat 126540

aatccaagga gtgggcaagt ttgaggccag ccaggcctaa aaacaaggaa aagagtatag 126600

aatcaggagt gttgttgtat atatgctgag tgtttggaca catggtacaa gtgtaggagt 126660

cacagcatga acaaaagcat tttgcactct gttctttcct acctctcacc cgccccagac 126720

aggatttttc tgtgttcccc tggctgtcct ggaactcact ctgtagacca ggctgacctc 126780

aaactcagag atccacctgt ctctgcctcc tgagtgctgg gattgaaggc gtgtatcacc 126840

accactcagc ttcttctacc tcttctgtag atctatctta tacttgtaca ataatctacc 126900

agctaagcca tgttcatgta cctaggcaca tgtaacaggt tcatgtacct aggcccatag 126960

gccaatctga tgtgggaagt cctccactga gacccttccc aggaaattct ggattgtgtc 127020

cgctgacagt taaagctcac agcacagctt cgtgtgcctg gggaatgggt ctacccatgg 127080

tgactatgac ttgtgcctct ttcaaatcat ggaatcttat acttgtcaca tcattgatgc 127140

ttagaaagtt ttagatttag gagcattttg ttttagttag aagtgttcaa cctataaggc 127200

catatgttaa ttttttgcac agtggccaca cttgtagtgt gatctttatc gctgtatctt 127260

ttagcacctt ccaagtttca tggattcatg cttttgttac ccccacagga catggactct 127320

ctgtgggaca ccagaatatc tcgccccaga agtcattcag agcaaaggtc atggaagggc 127380

tgtggactgg tgggcactgg gcattcttat attcgagatg ctgtctgggt gagtgaccct 127440

cctgacagac atggctgcat acacggccta tgaagaacct tagcatcccc tttttcctaa 127500

gtctgcagat acatggcata tggatgcact cacataatgt actgtcaaga ttgaagggtg 127560

attgggtgtt tagtttactt aaacaagact ttaacgtttc atagacatcc atagttactt 127620

atgtataaca tccatcttct ttatgtgatg gacacccaag gctaatcagt acccaaggtg 127680

aacaaatgac actaatcaga aacagctttg taagtagtga tggaagagca gatgaggaag 127740

gcaagctcag ttgttttatt caccctaatt tccctctctt ggcaatgcac aagatacagg 127800

agtgtgggct ctgtctctgt ctcccagttg atgggaaggt tggttgttcc tgatggtcac 127860

tggtagctgt ggaggcaagt atacacctga taaaaattgt gtaaacattg aaagcaagat 127920

tcccaagatc taggtgtagc cgagggaatt gtaggccaat accatgggag agttattcct 127980

ctggggaggt gacagttttc ccagtcccag gggcttttct ctggtactga gataaaggaa 128040

aattcatcct ttggtagatc aacccaggta ggaaaaaagc ttgaaggagg attttactaa 128100

aatagtgtga gatctgtcaa gagaaagaaa gcatctcctt acccacccac cagtcatcta 128160

tctacccact catctatcca catgtctatt cacctaccta aggcattaat ccacccaccc 128220

atccatccat ctatccactc tttcagctcc tggaggtgcc aggtgtgctt ggcttttgta 128280

gccccatcac ccccatctct gcagggcttc tgtgagtctg catctctttt tttgtctgtc 128340

atgaggtcac tgtcattgca tttaaggtca tctgcagcca gggtgtgctc atgtcaagat 128400

ctgtcactca ttctctaggc agagacccta tatgcaaatg atgtcacagt catgtgttct 128460

gaaaaatgta cacatattgt atgtgtttgt aatccatgaa gcttattttc ttaaaaattt 128520

acaaatataa aaccacattt atttatatac acataattta taatatagaa cataatttat 128580

tatatatata tataaaatct atggagtcta ccacatttat ttatatacac ataatttata 128640

atatagaaca taatttatta tatatatata taaaatctat ggagtctagt atatacctga 128700

taaaattgta taatcataca cacacacaca cacacacata tatatatata tatgtgcata 128760

catatacaca caagagaatg atttagaatc aacaaaaaat gattttttca cattgaagtg 128820

attgtgaaga gcctggggtc ccagtgtctt tgaagagggc atctccagca atctaacttc 128880

ttcccactaa acctggcttc ttgaaggttt ataatgatca cttccacccc ctgctgggaa 128940

ggaagctatc aactgaagct ctttgggagc cctcaggacc ctccatgctg tctctctcct 129000

cctgtggcta taccatctcc taagatcatc tgtttcccat ctgtcttcag atggtcatgt 129060

taacagttat caagcagtgg atccatttga caaaaaaaaa aaaatgtttg catccattaa 129120

gaaaaaataa tagttaacac aaaatagata taattctgta tttaactctc tactaaatat 129180

ccatgcttct ctctgtgaca ggtttccccc atttttcgat gacaacccgt ttgggattta 129240

ccagaaaatc cttgcatgca aaatagattt ccccagacaa ttggatttca cctctaagta 129300

agtgcactcc cggcccggtt tcctgccctg cccccatgtc tactttcaaa gttgtgtgaa 129360

atcacactgc aagcatacac tcctggcaaa ctggatcagt acaattctgt cagtcatttg 129420

tttccaccag gaaagaaaaa cgtttcagtt attctcattt tactgaaatt taatattcaa 129480

aagacctgct acatatctca tttcttttga gatggacagt gttgaaatta acgcagattt 129540

gggacaagtt gtgtaagcga tcagtttgtc catccatcca tccttccctc tatccaacta 129600

tctggttttt ttttcattta ttagttatta actaacttat tgaaacaggg tctcaattta 129660

tagccctagc tagcctggct agtcttgaac tcatagatat ctgacccctg agtgctgaga 129720

taaaaggtat gcaccaccat acacagcttc tttattaact ttttaacttg tctaaatttt 129780

taacttttct ttgaactgtt aagaagggct tagaggaaaa gttagtttat gggaagtatg 129840

accttgaagg agacaatgga ccctaggctc ttcttcatga tcatttccat gtgtaaatat 129900

agtatttttt attaattttt tgagatactt ccacacatat ggtgtgtttt aatggcattg 129960

gtttatttac tgagctagga gaatctttgt gaatgaatct ctgtgccacc acaaaagtta 130020

actttaattc atttttttct ttttactgaa attgtacata tcataaagaa ttccttttta 130080

ttaatcattt tgtttacatt tcaaatgtta tcccccttcc tggtctcccc tccacgaatc 130140

tctcaccccc tccccctcct ctttgcctct aataaggtgc tccccctacc cactcctgcc 130200

tcaaccctct agcatccccc ttctctgggt cattgagcct ccacagaacc aagggctgcc 130260

cctcccactg ctgccagatg aggcaatcct ctgctacata tgtagtggga gccatggacc 130320

aacccatgta tactctttgg ttggtagttt agtccctggg agctctgtgt ggtccagtta 130380

gttgatgttg atcttcctgt agggttgcaa tccccttcac cttttcagcc tttcccctaa 130440

ctcttccatt ggggaccccg ggctcaatcc aatggttggc tatgagtatc tccatctctt 130500

gtagtcaggc tctggcagaa cctctcagag gatggccata ccaggctcct gtctgcaagc 130560

acatcttggc atcagcaata gtgtcagggt ttggtgtctg cagatgaaat ggatcacatg 130620

gtgggacagt ctccagatgg cctttccttc agcctctgct ccattttttg ttgctgtatt 130680

tcctttagac agggagaatt ctgggtaaaa atttttagat aggtggatag ccccatccct 130740

ccaaaggagg ccatgcctat ctactggagg tagtctcttc aggttctgtt tccctgctgt 130800

tgtgtatttc agctaatgcc atccctattg ggtcctgaga gcctgtttca tccctggtgt 130860

cttggacgtt tgagtggttc cccaagttcc ccacctacca ctgctatttc tgtctattca 130920

ttctccttgg ccctctggag ttctctcctg tctcttctca tacctggtcc tgttctcctt 130980

tctttttcct ccctttcctc cctcccaccc aggtctttcc ttccctttgc ctcctgtgat 131040

tattttgttc ccccttctat gtgggagtga agcatccaca agttggcctt ccttcttgtt 131100

aaggttctat ggtttattat ttatatgggg gtattctgag cttttgggct aatatccact 131160

tatcagtgag tacataccat gaatatcctt ttgggtctgg gttacctcac tcaggagttt 131220

atttgcctac aaaactcatg aagttatcat tctgtagagc tcagtagtat tccattgtgt 131280

aaatgtacca cattttctgt atccattctt cagttgagag acatctaggt tatttacagc 131340

ttctggctat tataaataag gctgctatga acatagtgga gcatgtatcc ttgttatatg 131400

ttggagcatc ttttgagtat atgcccaaga gtggtatagc tggctcttca ggtagatcta 131460

tttcaaattt tctgaggaac cacagattga tttccagagt ggttgtacca gtttgcaatc 131520

ccaccaacaa tggagaagtg ttcctctttc tccacatcct tgccagcatc tgctgtcacc 131580

tgagtatctc agccattctg actggtgtga gatggaatct cagggttgtt ttgatttgca 131640

tttccatgat gactaaggat gttgaacatt tctctaggtg cttctcagcc attcggtatt 131700

cctctgttga aaattctctc tttatctctg tgccccattt ttaaattggg ttatttggtt 131760

ctctggagtc tttctttctt gagttctttg tatatattgg atattagccc tctattggat 131820

gtagggttgg taaaaatctt ttccaaatta ccaggttgct gttttattct gttgtccttt 131880

gccttacaga agtttttcag ttttcaaaat gagatcccat tttgtcaatt gttgatctta 131940

gagcctgagc cagtggtatt ctgttcagga aaattttccc tgtgccaatg tattcaaagt 132000

tctttcccac tttctcttgt attagattga acatatctgg ttttatatgc aagtccttga 132060

tccatttgga ctggaacttt gcacaaggag ataaaaacgg atcattttgc attcttctac 132120

atgcagacca ccagttgaac cagcaccatt tgttgaaaat gctgtttttt tcactgggtg 132180

gttttagctc ctttgtcaaa gatcaagtaa ccataagtgt gtgggttcat ttctgggtct 132240

tcaattctat tccattgatc ttcctgcctg actctgtacc agtaccatgt agtttttatc 132300

actattgctc tgtagtacag cttgaggtca gggatgatga gtcccctaga agttctttta 132360

ttgttgagaa ttgttttcgc tatcctgaat ttttggttat tccagaggaa gttgagaatt 132420

gattgctctt tctatctctg tgaagaattg agttggaatt tttatgggga ttgcattgaa 132480

tccatagatt gcttttggta agatggccat ttttactata ttaattctac ccatccatga 132540

gcatgggaga tttttccatc tcctgaggtc gtcttcgatt tctttcttca gagacttgaa 132600

gttcttgtct tataggtctt ttacttgccc agttagagtt aagtcaacat attttatatt 132660

atttgtgact attgtgaagg gtgttttctt gatttctttc ttagcccatt tacccttagt 132720

gtagaggaag gccactgatc tgtttaactt aattttatat ccagctactt tactgaagta 132780

gtttatcaag tgtaagagtt ctctgctaga atttttgggg ttgcttatgt atactatcat 132840

attgcctgca aatagggata ttttgacttc ttcctttcca atttgtatcg ctttgaccta 132900

attttgttgt ttaattgcta gctagaactt caagtactat attgcataaa tagagagaga 132960

gtgagcagcc ttggcttgac cctgatttta ctgagattgc ttcaagtttc tctccattta 133020

gtttgatatt ggctactggt ttgctctata ttgcttttaa tgtgtttagg tatgtacctt 133080

gaattcctga tctttccaag acttttagca tgaaggggag ttgtatttta ttggaggctt 133140

ttttcagcat ttaatgagat gatcatgtgg ttattttttc atttgagttt gtttatatag 133200

tggattatgt taatggattt gcatatattg aacatccctg catccctggg atgaagcctg 133260

cttgattgtg gtgaatgatg gttttgatgt gttctttgca agaattttat tgagtatttt 133320

tgtaacaata ttcataagca aaattggtct gaagttctct ttctttgttg ggtctttgtg 133380

ttgcataaat atcagtgtaa ctgtggcttc atagaacgaa ttgcgtagag taccttctct 133440

ttctattttg tggaatcgtt tgagaaatat tggtatttgg tcttctttga aggtctgata 133500

gaattctgca ctaaaactat ctggcccagg gctgtttttt tttttggggg ggggtgggac 133560

ttttaacgac tgcttctatt tccttagggg tttggggact gtttagacag tttatctggt 133620

cctgatttaa ctttcgttcc taaatctgtc tagaaaatca ttcatttcat ctagattttc 133680

cagtaggctt ttgtagtagg aactgaagat tttctaaatt ttttcagttt ctgttgttat 133740

gtctcccttt tcatttctga tgtaagatgt ttagaggtca acacactgct tcacaaacaa 133800

ttactcagta ttcatgttga ccatgcattt catgaagatt atggcaaaaa tagtgaaaaa 133860

gaaaaaacac agagcatatt tatatattta aaaaacatat aaataccttc aactttcttt 133920

gatttgaatg tggtcagatt tgagcatttt ctaaccagaa tgagctttgg tttccaattg 133980

tttctttagt tagttaggca gcaggatccc acatagccca gaacttctga tcccttttcc 134040

tcagccttct gaaggcaggg tgacaaacag acttgtgccc ccagtgatgc aacagatgag 134100

atccagggct aggtgaagac tgtactcact gagtataaga actcagaaag cactctgctc 134160

actgagctaa gaacatcctt ttcaccgagc tacagtccct gctggatatt atcataggtt 134220

ctatggattg cagggtgttt gggtatatga gtgctcagac atgtgcgcgc tcacacacac 134280

atacacacac acagccataa cccatggcat tctgtctcta ccctgcttta acttctctaa 134340

gtctttgatt taatccacct taccatcctt tgcattctct tgtcttttgt cgacaataga 134400

gacacaggag aataacagat atttgggaac tcattccata ggtgtgtgca gcctgcaaac 134460

tcagtttccc tgtacagaac tgtgtaaatg aacacaggtg tggtcttcaa aacagcctcc 134520

tcagttagtt acacaggaag gaacaatact ggaatggata aatgctaaag ggttgcaggc 134580

gaaacactgg cttatagctc agtgggtgga gtgcacataa ctcagtggag agagtgcttg 134640

aggcagagtg ggctgagtac ttgtagctca gtgggtagag tgcctgtggc tcagtatcta 134700

gaatgcatat agcttagtgg gcagagtgct tgtaactcag tggggagaat gtttatacct 134760

cagttggtag agagtttgta actcactgtg tagactgtct atagctcaca tggcatagta 134820

cttaactcag tgggtagagt gctggtggcc gagttggcac taacatgccc caagggctgg 134880

gctccatttc ttaccatgta aatggaaagc cagtctgcat ccgtggcata taggagattg 134940

aggctggaag acaggggttt aaggtcattg ttaggggttg gagcccagag tgcaagctgc 135000

ctacctgctt gctctcacaa atcctggtaa gtctttttcc cacaatagag ataccatgtg 135060

gtggtgtggg tggaatgagc acctcagttg attctggcat tttctggatc caagtggagt 135120

cttctctgct aacacaggga cctcatcaag aagctgctgg tggtggacag gacccgacgc 135180

ctaggcaaca tgaaggtgag tcatgctaga gcattccagt ttgcacactg acggtgatgt 135240

catccactaa gaggatccca gaccatgctc aatgttaaat tagtttttgg cttgtttgtt 135300

tgttgctggt ttgtttttat taattctgtg tatgtactac tcaggtttat tacctgccac 135360

agtggactca ggtcccctgc agctgcagtt acaggagatt gtctacttcc atatagatgc 135420

tgtgaatcta acctgggtcc tctgaaagag cagccatctc tctggcccct atttgctgtt 135480

ttcctgtagc ccagactaca atcaaaatca ctatgttgta gctaaggata accttgaact 135540

tgtgacccac tcaacctccc acctcccagg actgggatga catgcatatg cctccactca 135600

tggttgactt attctttatt tttgagtatt tatttattta taagacaggg tctcagtata 135660

tacttctgag tgtcctagaa atctcttttg tagactaggc tggcatcaaa gttatcatct 135720

gcctccttct ccagagtgct agaattaaag gcatgtgcca ccaaacctgg ccacttaatt 135780

tatttttaaa ttgctttatt ggagatttta gaaatgatac acatgcacac gcacatacac 135840

acacactttt tttttcaaat gctttttact gagtgtttat gtttcctctc aagaatgggg 135900

cagaagacat caagcggcac cggtggttcc gaggtgtgga gtgggaatct gtgccacaaa 135960

gaaaactgaa ggtgggagta ttatacaccc ttgaattaaa tgaacagctt catatatggt 136020

cctaaccacc cagtgagctc ccactactgt gtctcagtct tccaaattaa tttactagag 136080

gtttattgtc atttattttg cgcttgatgt atgtgtattg tttctgtgtt catgcgcacc 136140

atgtgacttc agtactggag taccttcagc ctctcataaa atttgtattc caagtgacag 136200

gcattacatg tccccactgg gctacccagt gtcacctcat tcacttattt tatttctttg 136260

ttgctttgtt tattttgaat gactctcagc cacccattgt gcccaagtta tcgggtgatg 136320

gtgacatctc caactttgag acttatccag agagtgaatt ggacaagaca ccttctgtat 136380

ctgacaaaga cctggaaaca ttcaaaaatt tctgaggatg agaactcatg tctgaaaggt 136440

aaaacttttt ttttttctga atttctaagt agggtgtcat gtagccaaag atagctttta 136500

atttaccatg tagttgagaa aatatacatt cagtgcaact gagaatgatg aattaaccag 136560

tctgcagggt ttcttactat gtatgattgt caggtaactc agtagtaaat gttgataatc 136620

tctgaaccct cccccttcct tttctttgcc agatgtatgt gaagacatcg ataccacacc 136680

ataccacacc acagcacaac ataccacacc aatggccaga accttttttg tcgtacgttt 136740

ccatttccta ctatgaaact agaaggtttg gtgtgtgtat tccagttcct gaaagatcaa 136800

tacaatcatc acccttggaa cccagcctca tttcaacaac tggaaacctg cccaatgaga 136860

attcgcaaaa cctgttaaat tgtaggtttt ctccttcttc atgagtcttg tgtttgtgct 136920

gtgaattttg tttctttttt tgtttgtttg tctttctact gaacttttta agtttgaatt 136980

tgacccattt ggttttatgg ctgtcagtgt atatgtgcac agaaattgtg caaactggaa 137040

attttggcac tttgtgcttg tgacatgttc attttttaaa gctttctgaa aaatctttca 137100

ccctacaggc aaaaaaaaaa agggtgagat atatgctttt taaaaatgcc tttctatgca 137160

ttttgcaatc atttgtgtac attgtttatt tagttactgt ttgtttattt agttcctttc 137220

tggtcacttt aaacttggaa gtcaggaagc cacatgccct gcagaccctt attcagatat 137280

agcacaaatg tgtggctttc ctccaatctt ccagtttaga tgttttcagt aaaatatccc 137340

ttcctaaagt taagccagaa ctctgcatac agcatggcac ctgggtgcaa agattgcctt 137400

tttatgataa tacaaatgta cccacatccc cacaagggaa ctttaaggat ccacccctta 137460

agcccctccc tcctctgttg taaatggcat tttcttctca ccatcttaac tttgttctcc 137520

cagccatgtc cgtccgtgaa aactcaggtt ccaggccggg aacttctatg aaagtttgta 137580

cagagctgta tttttggtga gctttctcag tgctttccaa tatgcaaact aactgggtta 137640

tgtacctcaa acaaacaaac acatacagga gatagaatgc aggattataa tcaagtcctg 137700

tcagtagatg tttgctatta agtaggaaat aacatgaaat tagcatagga aatattgcct 137760

taattctaaa cacacatggg gagatcacac atgcgcacat gcaccctctg tgtgctccta 137820

aagcaccttg caatctgact ccaatcctaa aaatcaaata aaaaaccctt aatcaggctg 137880

taaatcaaat gacactatgc gatgtcacta cagtgacatc agacatcata taggaatcat 137940

aattttctat tttaagattt ttaattctgt gtgtacatgt gactgcagta cacacagcca 138000

acaagtgcac cagagaccct acagctggac ttataggcag ttctatgccg ccctgcggat 138060

gctgagaacc aacccaacct cgatcctctg cagtccatgt agttaacatg caagaagggg 138120

tggtaaggca aaagcagcca tgaaaaaggg tgagggaaat atgtcctgtt cttaactctg 138180

agtccaggga gagttgtgca cccaacacct tctcatgaaa caatggaata gttaataaat 138240

ttcaaatttc tctggtggta gcttgattcg aaccaaagta taaaagataa tcactagcaa 138300

ataaaaattt aaaaacaaat ttctgggctg gagagatggc tcagcggtta agagcagtga 138360

ctgctcttcc ggaggtcctg agttcaaatc ccagcatcaa cctggtggct cacaactatc 138420

tgtaatggga tccgatgccc ttttctgatg tgtctaaaga cagctacaat gtacttacat 138480

ataataaata aataaatctt aaaaagcaaa aaaaaaaaaa aggaaatccc ctcttttaaa 138540

aaaaaaaaaa acaaatctct atgctcttca actaagactg actttaatgt ttagtacaga 138600

taaagtacta cgtgctgtgg attggtgctt gtctcactaa actagctgtt acatgttaca 138660

ctgtagaatg tgatttgatg gcttaatact gttcacagga ccctctggct gtgcaaatat 138720

cccaacattg gaccaaaaca taccaatcac cactgtgttg ctaggtgaac cctagtgaaa 138780

atttagcatt gtgtgggtct tgatgttgag gtgaaaatca cagaaagggt ctcacttctg 138840

actgtagatt tgaaatatgt tgatttcctg ggatttgttt gtttgttttt gttattgttt 138900

tggatgaagc tccgtaggaa gcatttgatg aacattcaac acctgtcatt cttatttgtc 138960

agaacactgt aaaccacctg aaacttataa tgcaaagtca aggtttatgt gtgagttggt 139020

gcccccatta ggttgtgttt gttcccatca gtttaggggg aggatctgct tcccaactgt 139080

taaatgttac tatcaaatct gcctttgagt ctcacaccct tgcatctggc ctcacagtta 139140

tttgggagag ggaggttgct ccagttggtt atgtaataga catcatgaca tcattatctg 139200

tgtgacttag agaaagtgag caccccagcg ctcctggtcc tcacatgtca gactaaaacc 139260

ccttgtcacc tccgttcttc tcagagtgtg gggctcatca cttgacctgc tataacacag 139320

gtcccacgtg cactgttcag gtgcaccccc ccccctgctg ccgagcaacc gtcagcttgc 139380

ctgaaattat gcagaatgaa aaagcctgtt tctttttcct tttttatcct gatgcatatt 139440

aaaaaaaatc actgtgattt gtgtgtatat ctctctatat atttgcccca ggaaaacttt 139500

ctgctgtcta atttataaaa tactattact gagtccaggt ttgtttaata aaagtttgta 139560

tgttttaaga aatctgtttc aggtcgtttc ttgacttttc ctgtaacaca gggtaacacc 139620

ataaaacaca agtcattgac catggttaat gacctcagtg atccagtcac caacagtagt 139680

tggtgcccat ttctcagagg cagaactagt gaagctgaaa tgaagttggg ttaatcaagg 139740

aaattggtct gcacccctgt aacaggttga tgattgtttt gaggaatatt agtacccagg 139800

atagtggaag tattacaaac ttcagacgtc attaacttgg gggatggggg tagggtggtg 139860

cataacctaa gtcacaagag tgtgctatgt gggatttctt ttctggtcct tatacgtttc 139920

tgtgcatctc tttatttttc ttttactttt tttaatgaat aatatcttta tttacattac 139980

aaatgttatc ctctttccca gttcccctcc ccagaagccc cctatcccat ccctctaccc 140040

cctgcttcta tgagggtgtt ccctcaccca cccaccaact cctacctccc tgccctcgat 140100

tcacctacac tggggtatcg agccttcaca ggaccaaggg cctctactcc cactgatacc 140160

taacaaggcc atcctctact acatatgcgg ctggagccat gggtccctcc atgtgtactc 140220

cttggttggt ggtttagtcc ctgggagctt tgggggatct gggtggttga tattgttgtt 140280

cttcctatgg ggttgcaaac cccttcagct ccttcagtcc tttctctaac tcctccattg 140340

gggaccctgt gctcagtcca gtggttggct gtgagcatcg cctctgtatt tatcaggctc 140400

tggcagggcc tctcaagaga tagctatata aggctcctgt cagcatgcac ttcttggaat 140460

ccacaatagt ttctgcattt ggtgactgta tatgggatag atccccaggt ggggcagtct 140520

ctggatgacc tttccttcag tctctgcttc atactttatc tccatatttg ctcctgtgag 140580

tagtttgtta cttcatctaa gaaggaccaa agcacccaca cttcggtctt ccttcttgag 140640

catcatgtgg tctgtgaatt gtatcttggg tattccgagc ttttgggcta atgtccactt 140700

atcagtgagt acataccatg ggtgttcttt tgtatcttgg ttacctcact caggatattt 140760

tctagttcca tccagttgcc taagaatttc atgaaattat tgttcttaat agctgagtgg 140820

tactccattg tataaatgta ccacattttc tgtatctatt cctctgttga aggacatctg 140880

ggttctttcc aacttctagc tattataaat aaggctgtta tgaacatagt ggagcatgtg 140940

accttgttat gtgttggaga atctttgggg tatgtgctca ggaatggttc tcttagtttt 141000

aatctattgg tttctgccct gactttgatc atttcctgct atcgctcctc ctgtgtgtgt 141060

ttgcttcttt tttctaaagt cgtcagatat acttttaata tgttagtatg agaactctcc 141120

aatttgttta tggaggcatt tggtgctata aactttcctc ttaaccctgc ttttagagtg 141180

tcccataagt ttggatatgt tgtgccctca ttttcattga attctagaaa gttattcatt 141240

cctttctttt ctctgacccc agtgatcatt gttgttgttc agttttgatg aggagtatgt 141300

ggactttctg ttgtttctgt tgttgttgtt gttgttgttg ttgttgttgt tgttgttgtt 141360

gaagttcaga tttaatccat ggtgatctga taggatggga ttatttcaat cttcttgtat 141420

ctgttgagac ttggtttgtg acagactata tggtcagttt cggagaaggt tccgtgaggt 141480

gctgagaagg tatattcttt tgtatttggg tgatagatat atgttaagtc catttaaatc 141540

ataacctctg ttagttttgt tatttctctg tttagtttct gtctcaatga cctgtcaatt 141600

ggtaagagtg gaatggtgaa gtctcccact attagcgtgt gggattcatg tgtgattaat 141660

ctttagtaat gcatctttta cgaatgtggg tgcctttgca tttgaggcat agttgttcag 141720

aactgagatg ccttcttggt tgattttcct ttagtgagta tgaagtattc ttcctggtca 141780

tttctgattg cttttggttg aaagtctgtt ttattagata ttaaaatggc tagtccatct 141840

tgtttcttag gtgcatttgc ttgaaaaacc tttttttcag cctttattaa tatctatctt 141900

tttgctgaga tgtttcttgt gtacagcaga atgatggatt ctatttacac atccattcag 141960

ctagcctgcg tcttttaact ggggaattga atctatggat gttaagagat attaatgatc 142020

aatgattgtt ataactttct gttattttga tggtggtagt ggtggtagta tgtgtgtgtg 142080

tttctcttct attttaatgg tgtggatcta tttatttatt tatttattta ttcattgtat 142140

tttctttagt gtagttagcc tcattgggtt tgacttttcc ttctagtatc ctctgaaggg 142200

ttgggatagt ggaaaggtag tttgaatttg gctttgtcat agaatatctt agtttcttca 142260

tctatgttga ctgaaagttt tgctggggca gtgagccccg tctgccagac cttcaaggtt 142320

ccaccatgtt ctcgaaggtg agtattgtca ggctgtcggc ctgtgccacg cagccgcaat 142380

ggatccaagt ttgaaacatg gcaactctga aagatattac caggagactg aagtccatca 142440

aaaatatcca gaaaattacc aagtctatga agatggtggc agctataaag tacacccggg 142500

ctgagcggga gctgaagcct actcaagcgt atggaacagg gacctgagga caataagaag 142560

cacctcatta ttggtgtgtc ctcagataga gggctttgtg gtgctattca ttcctcagtg 142620

gctaaacaga tgaagaatga agtggctgcc ctcacagcag ctgggaaaaa agttatgatt 142680

gtttgagttg gtgaaaaaat caaggtcata ctttatagga ctcattctga tcagtttttg 142740

gtgtcattca aagatgtgcg acagaagccc cctacttttg gagatgcacc agtcattgcc 142800

cttgagtttt taaattctgg atatgaattt gataacgact ctatcatttt taatcagttc 142860

aagcttgtta tctcctacaa gacagaagag aaacccatct tctctctcaa taccattgcg 142920

actgctgaga ccatgagcat ttatgatgac attgatgctg atgtgctgca gaattaccag 142980

gaatacaatc tggccaacct catctactac tccctgaagg agtccaccac cagtgagcag 143040

agtgccagga tgactgccat ggacaacacc agcaagaatg cttctgatat gattgacaaa 143100

ttgacgttga ctttcaacca cacccgccag gatgtcatca caaaggagtt ggttgaaatc 143160

atcatcatca tgctgctctg aattaatgaa aatcaagttg tatcctcaga caagaggtaa 143220

agaagaagaa tgtgcaggct gattttaact gattgctatc tttgtcagaa gaaacttggt 143280

ccactgagtt acaaagatag caggatgttt gttgagaaat tgggtgtaag tataatatat 143340

ccatctttat attttacttg gcctttttcc cttgcagctt ttaatattct ttcttctata 143400

tatttagtgt tatgattatt atgtgacagg aggactttct tttctggtcc aatctgtttg 143460

gtgttcttta ggcttcttat acatttatat ccatctcttt ctttaggtta gggataattt 143520

cttctatgat tttgttgaag atgtttctgg acctttgagc tggcaatctt ctccttcttc 143580

tatttctatt attcttaggt ttggcttgtt catagtgtcc caagtttcct ggatgtttcg 143640

tgtcatgaac tttttagatt ttgcattttc tttgacataa atattgatat ctactactac 143700

tactgactca tctcttgtat tctgttgatg aggcttgtat ctttagttct tgttctcttt 143760

cctaggtttt ccatctccag gatttcctca gtttgtgttt tctttattgc ttctatttct 143820

cttttaaagt cttgtacagt tttattcata tccttcacct gtttggtcgg attttcctgt 143880

ctttctttat atttatttgc ttccttgttt aatgcttcta actgtttgaa tgtacttttc 143940

tgtagttgtt tgtttgtttg cttttcaaga cagggtttct ctgtgcagtc ctggctgtct 144000

tggaactctg tagaccaggc tggcctcgaa ctcagaaatc tgcctgccac cacctcccaa 144060

gtgctgggat taaaggtgtg caccaccact gcccggcttc tgtatttctt tatgggattt 144120

attcatgtcc tctttaaagg cctctatctt tataagactg gatttaagat cctcttcttg 144180

tgtttcagtt tccttagggt atacagggtt tgttgtggca gcacagctga gctctggtgg 144240

tgccatacta ccctaggtct tgttggttgt gttcttaagc tagcttttag gcatctgctt 144300

ttccctggtg ttggctgtat gatcctgatg ccagcaggac ttctctggaa gatgggggag 144360

ccatagtaca gacaatggag gtcaggttac acaattctgg gggctgtgcc tgaggtggac 144420

cccactgata agggattggt ggagcaatgc tccaacctgg aagttcttgg ggtttccaca 144480

ggcctccaca tagaaacagg atgctcttga ggtcccctaa ggctcttcag gactgaagag 144540

caagcccaga actaggcagt agagttcagg ggactgtgca caactctgcc tgctgtatcc 144600

caggtggacc caactgagaa gggattggtg gagcaggttt ccaagctggt tagttttggg 144660

gtctggaagt cttccacagg aaagcatgac agtcttggga tcctccaagg ttctgtcagg 144720

actgaagagc taattcagag ttagataatc aagttccctt tgatttttca tgtgactttt 144780

ttgtataaca tacatttaca tttattaatg aatatctcta aaatcagcaa ccattaaaaa 144840

gtgattgcat tatgtggtca agcagaacta gcaactttcg ttttttaaaa agcacaaatc 144900

ttaaaaatct caatttattc acatacataa tacagcatac tagttatgtt aaatgctaca 144960

aaccaatgtg agtctaatcg gatggggaaa agcacacatt taagctttaa gaaacatttt 145020

tccctatata ttagcatttt cttaaataca tacatgagat aaatgaggta actataaaat 145080

atacagggaa caaccatcca tcttgtgtat atgtatatgt atatgtatat atatatatat 145140

atatttatat ttatatatat atatatatat atatatatat atatatatat acacacacac 145200

acatgcatac atacatctat aaaacctttc taacacagaa aacagtgctg ggcccacatt 145260

gttaggaaaa gataactact attatgacta ggccagaagt tggtaaataa agagtaaaca 145320

atgccaagcc cccaccacag gaaaccattg gtaacatgga gtctatagca aggtcagcaa 145380

atcacaaaca tcctaagtaa ttgtgttcca agatatttga tcacattgtg aaccccaaga 145440

ttgtgaactg gaaaaaaaaa aactttcttg ttgttgtatg gcttagccct agcacacacc 145500

tttaacccaa gagctttctt tttttgttgt tgtttctttt tttttccatt ttttattagg 145560

tatttacctc atttacattt ccaatgctat accaaaagtc ccccataccc acccaccccc 145620

actcccctac ccacccactc cccctttttg gccctggcat tcccctgtac tggggcatat 145680

aaagttccaa gagctttcta taaataagag ctaaataaag tcaactgtag gtcaagaggc 145740

agagcaaaca accaattgag agagagtgaa catagaaagt agaatggacg gacattgagt 145800

tgaaggttat ttaagacagt ataaagaagg aaaaggaact ttttccttct gggacactgg 145860

tggaatagaa aggtcaactg ggtgcttttt tctgcctctc tgaactagca ggctctcatc 145920

ataatgtctg gcttttgagt cttcatttgg caaatagaac atttgggatt ctgtttttaa 145980

aacaacataa ctgtttcata attagttttt aaataatttt aaaaagtgta tacccctcag 146040

acctgcttgt tggtattact gtagccaaca caatccatga gccaattctg ctgtcccagg 146100

gtttcaaatc acagggtttg aatttttttg ttgttgttgg agtgaggaag agatagaggt 146160

tggagaaggt ggttctctgt gtaaaacagg tagataaata tagtgtaacc atcacctggt 146220

tacatacagt aaactttagg ttcttgtagg gtgggccaat gggcccctgg caggctgggt 146280

gggatgcagg aaacctgggc tgctgcatga gaatggggtt tgttggaaca ggcctgctat 146340

caggtgctgg ccccacaagt ggtttattca cttagggcaa caaccccaga tggggatagg 146400

aaaggaaata aatgggactt gaaagtgtag ggaactcaga cttctccaga ccttgagggc 146460

aggagtcagg ccaggaaggg ccataagata gaggttcatg ccctccttgt ctctgtcctt 146520

atgggattcc taggagactc acccaggcag gtgagagaca ggccctgact ggagaggaaa 146580

tgccttgaaa atcaaacagt cctggtagtc tcatgtgact tataaacact tttattaaaa 146640

cactcccttg gtttttcttt tctttttaag atttatttat tattatatct aagtacactg 146700

ttttagctgt acttcagatg caccagaaga gggtgtcaga tctcatcatg gatggttgtg 146760

agccaccatg tagttgctgg gatttgaact caagaccttc ggaagagcag tcagtgctct 146820

taaccactga gccatctctc atcacaggtt tttgtgtctt aaatgctgtc ttgttacata 146880

accagagtgg tctgaagctc agattggcat tagacacact gttgtcttcc tcctaccaag 146940

gctttgcagc tggagttagg gatggttgta aactactatg tgggtactgg gagtcaaacc 147000

aggggcctct actagagtaa ccagtgttct ttaaaaatga tttatttatt tgttttatat 147060

aagtacactg tagctgtctt caaatacacc agaagagggc atggatccca ttacagatgg 147120

ttgtaagcca tcatgtggtt gctggggatt gaactcagga cctctggcag agcagtcaat 147180

gctcttaacc actgagtcat ctctccagca cctaaatgct gaaattctaa tttgtacctt 147240

ccctacaaag gtagaaacaa atgctaatgt atgctttgta tgaattattg tgactcagaa 147300

tgaggtagtt gactgtgtct tgcaagcccg aggccctacc tttgatcttc agtgccatac 147360

agaaacaaaa caaacgtatt aaagagtcct cagattttca gtagctcccc tttctgcctc 147420

tatacatgtg gccatagatt ggattggaca aataggcaga tggagaccct gtgaggggtg 147480

agatgagcaa aattattcta gaagtagtac agggggtaca ctaaggctga ctggtctttg 147540

gggtaaaatg gtttgttata ccacagaaag acagcaaggc aagaagagct cttgagggga 147600

actctggtcc atgtgggaaa gtaggaatcc ctccttgtac gcttaggagg aggggtaaaa 147660

atccatgcta catacacaaa agattttatg cttgtaactg acatgattgc agtagttccc 147720

acagaccacc ttcactgcaa gacagaagtt ctaagcatag gctgtgatct gcagaaagga 147780

cccttgacaa tgtcaaatga cagttttgct tccactttgg agaaggcatt tttcccaaca 147840

tggagaggta tccattgctt ctcagaattc tagagtgctt agaatggcct tgctacttgc 147900

aatatgccca agggtcctta ctctcaactc cagaaactct ctgtatgact attatcaaca 147960

ataatattaa ataatgcatt actattattt atttgtctaa atttttattg aatctctata 148020

tagtatattc catctattta cctgtcaata tttatctcat ttttttctct tgaaaatatt 148080

tctgtgcatc aatgtttttc ttgcaggtat gtatacctag tgccgatata gactgtaagg 148140

atcccatgga attgaagttg cagatggttg taagaggcca tgtggaggct gtaaatcaag 148200

ccttggtccc acagaagagc agcaaatgca ttttaatagg tgatccatca gtccaggact 148260

cattcttccc ttttctattt gagggagcat ctgtaagcct aaaggggcct tgaagtcaca 148320

atcctcctgt ctcagcttcc aggggactgg gagtgtagtt gagtctgctc taactaaact 148380

taacaggctt ttatggtgct tagtgccaat aagtaaaatg atggagatga gaaaatgaaa 148440

agagcccaga gcagaagata gatgcccaag gccaacccag atttaaatat ggattaggct 148500

caggaggcca gggtacattt accatgctag aggctcatca ggggctatag acacctgttg 148560

tgtactggat ctgatcctgg attgggtcca caagtgctct ggaatttttt ttaattaggt 148620

attttcctca tttacatttc caatgctatc ccaaaagtcc cccataccct cccccccatt 148680

ctcctaccca cccactccca cttcttggcc ctggcgttcc cctgtactga ggtgtactga 148740

ggcatataaa gtttgcaagt acaatgggcc tctcttccca atgatggccg actaggccat 148800

cttctgatac atatgcagct agagacacga gctccggggt actggttagt tcatattgtt 148860

gttctaccta taggactgca gatcccttta ggtccttggg tactttctct agctcctcca 148920

ttggggaccc tgtgatccat ccaatagctg actgtgagca tccacttctg tgtttgctag 148980

gctccagcat agtctcacaa gagacagcta tatcagagtc ctttcagcaa aatcttgcta 149040

gtgtatgcaa tggtgtcagc gtttggaggc tgattatggg atggatcccc ggatatggta 149100

gtctctagat ggtccatcct tttgtctcag ctccaaactt tgtctctgta actccttcca 149160

tgggtgttta gttcccaatt ctaagaaggg gcaaagtgtc cacactttgg ttttcattct 149220

tcttcagttt catgtacttt gtatcttgta tcttgggtat tctaagtttc tgggctaata 149280

tccacttatc agtgagtaca tgtcatgtga gttcttttgt gattgggtta cctcactcag 149340

aatgatgccc tccaggtcca tccatttgcc taggaatttc ataaattcat tctttttaat 149400

agctgagcag tactccattg tgtaaatgta acacattttc tgtatccatt cctctgttga 149460

ggggcttctg ggttctttcc agcttctagc tattataaat agggctgcta taaacatagt 149520

ggagcatgtg tttttcttac cggttggaac atcttctgga tatatgccca ggagaggtat 149580

tgctggatcc tccagtagta ctatgtccaa ttttctgagg aaccaccaga ctgatttcca 149640

gagttgtaca agtttacaat cccaccagca atgaaggagt gttcctcttt ctccacatcc 149700

ttgccagcac ctgaattctt gatcttagcc attttgactg gtgtaagatg gaatctcagg 149760

gctgttttgg tttgcatttc cctgatggtt aaggatgctg aacatttttt caggtgcttc 149820

tcagccactc ggtattcctc aggtgagaat tctttgttta gctctgagcc tcatttttta 149880

atggggtttt ctgattttct ggagtccacc ttcttgagtt ctttatatat gttggatatt 149940

cgtcccctat ctgatttagg ataggtaaag atcctttccc agtctgttgg tggccttttt 150000

gtcttattga cggtgtcctt tgccttacag aagctttgca gtttcatgag gtcccatttg 150060

tcaattctca atcttacagc acaagacatt gctgttctat tcaggaattt tccccctgtg 150120

cttttcccca ctttctcctc tataagtttc actgtctctg gttttatgtg gagttccttg 150180

atccacttag atttgacctt aatacaagga gataggaatg gatcaattcg cattcttcca 150240

catgttaact gccagttgtg ccagtaccgt ttgttgaaaa tgctgtcttt tttcccattg 150300

catggtttta gctcccttgt caaagatcaa gtgatcatag gtgtgtggat tcatttctgg 150360

gtcttcaatt cttttccact ggtctacttg tctgtcagta taccagtacc atgcagtttt 150420

tatcacaatt gctctgtagt acatctttag gtccggcatg gtgattccac cagaggttct 150480

tttatccttg agaagagttt ttgctatcct atgttttttg ttattccaga tgaatttgca 150540

gattcctctt tctgattcgt tgaagaattg agttggaatt ttgatgggga ttgcattgaa 150600

tctgtagatt gcttttggca agatagccat ttttactata tcgatcctgc caatccatga 150660

gcatgggaga tctttccatc ttctgagatc ttctataatt tctttcttca gagacttgaa 150720

gttcttttca tacagatctt tcacttcctt atttagagtc atgccaaggt attttatatt 150780

atttgtgact attgagaagg gtgttgtatc cctgatttct ttctcagctt gtttattctt 150840

tgtgtagaga aagggctctg gaatttttac atcttccagt gggtttagca gagtccataa 150900

acctaggctg gtgactagat ccaacattgg gttaggtcat cctggtctac agaatgagtt 150960

ccaggacagc cagagctaca tagtaattcc ctgtctcaaa aaaaaaaatt aaaaagaaag 151020

aaacaaagaa agaaagaaag aaagaaagga aggaaggaag gaaggaagga aggaaggaag 151080

gaaggaagag agaaagaaag aacaacatga gttagggaac tgtagagctg gctttctaat 151140

gcaaacactt acactagatc taaagctctg actatagtcc cctaaacctt aacatgacaa 151200

agtatacact catacaccta gacccagacc taccttacat ctcaaagata atttacattc 151260

acaagtattg taattgaatg ctacaggaaa aaatggacaa aatatgaaac ctatcagatt 151320

ttggtataaa aatcaatttt aatgctttca ctaaccctaa gaccatgacc ataatcccct 151380

aatgctaatc ctaaccttaa cacagcagac cacaaaacac tccttactta taaaaaaaca 151440

aaactaacat aaccttacct tgcatcatag acataactta tattaagaga catggtaact 151500

tgatgttagg tcaaaaaaaa tgggatagat tatgaaacct attggatttg ggtgtaaaac 151560

tttcccaaat atcaagatta gaaactcagg ttttgagaag catgattgaa tcttttttga 151620

ggcaataaaa aatttaaacc tggaggatga tggtggcata tgcctagaat cccatcactc 151680

cggagacaga ggcagatgga actctatgag ttcgaggaca gcctggtcta tagaatgagt 151740

tcaaggacag tcagagccac acaaagaaaa acctgtctca gtaaaatcaa aaaacaaaac 151800

accaaaaaac ccaccactgc cactaccaac aataaataaa taaataaata aataaataaa 151860

taaataaata agtttaaacc tgcggttact agactaatgg gtaactctat gatgctttat 151920

agctctattt ccttgagtca gaatgactgg agaagtgctc tgcagattcc agatggaatg 151980

aaagctatta acctagaaat ggtacactga ggcaaaggaa cccaggcagg gtggtagagt 152040

gaagaaattg cagccataga agtctctaca ccaaaggtga agactaagga gcagcactca 152100

acatctatag ggtcttgggg gccccttgag ttcctacaaa atgcctctgc ctcataaaca 152160

atatgtttgt ctggaagtca gctactttca gccccctatc ataaaacgat aacggaacct 152220

gccatgtcca ggtctgtctg acatgcagaa gtccaagtaa caagatttgg ctatacactt 152280

cttaaagatt ctctgtctcg ctgtctctct gtctctgtct gtctccttct gtctctgtct 152340

ttctgtgtgt atttatatac aagtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 152400

gtgtgtgtgt gtggtgagta cctatttact gactcttggg ccttagtaaa atatattgca 152460

atctgctcta aaactagaag gcaagttttt acaatcagta gatatttgtt ctaaagaggc 152520

ctggattttt aaagcaaaat ctgatatcaa aatatctgtg agggaggcat gacactagca 152580

aagatataga agaagccaga cataataata ccattatgat caactatcca agataagtgc 152640

caccagatat aagattaaca aggaacaaat acctagaacc agaatcaaag gggaaaatga 152700

cacatgggaa taaatactac ctaccattaa gctacagaag atcacttgtg tttattgcca 152760

ctataccaaa aactaggaca tcaaggaaca caaggactaa aacactgaat agactaatgc 152820

aatattcagg aatcctggca tgttattaag aatactatta gctagatggt tgtggaacac 152880

acctttaatc ccgacactca ggaggcagag gcaagagact ctctgagttt gagatcaccc 152940

tggtctacag agtgagttcc aggagagcca gggctacatg gagaaactct gtcttgaaaa 153000

acaaacaacc aaatactatt aaaggttgtg aaaaaagttc tcacggatac tttttaacta 153060

gatacaactc tattggtaag gctacacact gtaagatata tgtatttaac tatacaatac 153120

aaatacactt cgtaggacca ttgatcaaat atagaagtaa atatacatgc acaatggcaa 153180

acacctttat aggattaggc attgtagtgc gcatacccta ctcagcaagc ctccatgaac 153240

aatctttggt tctggtacac agcctttgat tgtcctaagt ttataataga ctctgacaaa 153300

ggctcatact tcgcaggcaa aatgacacaa gaaacggcaa ataattagat atctaatgga 153360

atttctatat accatatagc cctagaacat caggaaacat gagagatgca atgctttgat 153420

caaagaataa ttaatgttgt ctggttaaat ttacctgcaa ttggctttta ttaataaagc 153480

agcttatacc ctgacccagc tgggacttag cctgtctata ttggcttgtt cttttccaaa 153540

atctggactt cagcaacatc tccaataaaa cctggagata ttaagcactg actacactat 153600

ttgcttcagt ggcacattgg ttgaaagatg aaatgaaaga taaaggtggc attgccacct 153660

tcaaatcaat gttctcacaa cttagtggga catagtataa gactaatttg cacaggccct 153720

aattggtcta aagcagctct catcactctt tgtgacttta ctaccttaat taagttttat 153780

cagttccatt cactttatat gcaaattgtt tttgagattt ggcctctcag acatatttaa 153840

gttaggagaa gaactaccag atataccatt atttgaaagc ataataacct ttctagaact 153900

tataaacaaa tttactatac aacctcatat tgggagcaga ttttgttttg gtcctggaag 153960

acaaagaatg gaactagatc ttaagacgta atggtagata cacacccctt cactctcttc 154020

acactttata ttgccttaat tgtagtctta ctcagttttg aactggctct atatcaaata 154080

ctatgaacac ctctctccaa gcaccacgca cctactggga tacaacacac taacatttag 154140

aaagaagtgg atcaaacctc tctttgtgtt gatgataggt agaaggccct ctttgaagct 154200

actaccacta ctgtcactgt agccatctgg acctagctca ctatattcat ttccccagaa 154260

ctccccaata ttgtaggatg gaaggactta atgtaaccat cagacttgat aataacaata 154320

gccgcctatt ggaatgttac agaattggca cataaacctg ttgtcttagg atctccattg 154380

ctgtgaagag acaccacagc aacttttata aaggatatca tttaattggg gctggcttac 154440

aggttcagag gttcagacta ttatcatcat gatggaaaac atgacaacat ccaggaagaa 154500

atgatgctga agtggtaact gagagttcta tatcttgatc cacagacagc agaagactga 154560

tgtgacacac tggtcagact tgagcttttt agacttcaaa gctcataccc agtagcctac 154620

ttcctccaac aaggccacac ttactccaac atagccacac atccttattg tgccacttcc 154680

tatgaccaaa cattcaaaca catgaatcta tgtgggccac cacacctgtt gagatgcaca 154740

tgataataaa tgcaaacagg ctatgcagaa tagtaagcat tttaactcac aacttaagag 154800

ctttaccaac ctagacaaat gcaataatcc tactaaagcc tctagcaata ctaattgttg 154860

aaaataactg gaggattaca gaaaggcaca aaaaagcaat ttatgcagac cactggatat 154920

acttagaaca aatggagctc ttgtctctag ctgcatatgt atcaaaagat ggcctaatag 154980

gccatcactt gaaagagaga tccattggac ttgcaaactt tatatgcccc agtacagggg 155040

aacgccaggg ccaaaaaggg ggagtgggtg ggtaggggag tgggggtggg gtgggtatgg 155100

gggacttttg gtatagcatt ggaaatgtaa atgagctaaa tacctaataa aaatggaaaa 155160

aataaaaata aataaaagag taaaaaaaac ataaaaaatc aatgttgatc aacacatttc 155220

gtctgctaag atgccctacc tacaagatga gtttttaatt attccaagct ggtactctga 155280

tggaactctt acaagtaaca cagctatgga agtcagcttt atactaattc tggtacccat 155340

atgggatgga aaagataagg actataaata tgtagaaact gaggtatcca acaataagga 155400

tgacacagca acaataacaa ccaaaccata ttttaatcct ctcaagccat attttaatcc 155460

atctaatgac agtatatcct tcatatttag aatacaagaa ggaacagatt taaaaagaaa 155520

tgagcaatga gagtatatat tatgttttag gcttcattaa ttttccatac tttggacatc 155580

tctctctctc tgaccaccca tgaggtgaag gagttcacag aagtctcatc ttgggacagc 155640

tgatctctaa tacctcttaa tcccccatca ttatgggatt ctaatacttt tggaatatat 155700

tgggacatat accaattccc acttgtgcct actgaaccca aatgtctgcc ctactcttta 155760

gaaagattac aacaaaagtc tttaagacag aaccaggcac ttactctcct aaattcctat 155820

cccattattt catattatta gaaaccaagc tagtggcaca tgtaaattta attttatcac 155880

agccccaaac tataactcta cattgcctaa ctttgaaatg atttgtgtat gtttagaatt 155940

aaaacaaaac cttccacttt tacggggtca caattggaca atatttgggg caatcaactt 156000

gtagaaaact ggttagctta ggcagaaaat cgcaactcta aaatcactgt ccaacacaga 156060

tggaacatgt ctggagaagt gtatctccta gtggtatggg gtggtactac aatgagatga 156120

gcactcatac tactttggct caatgtaaca atcctggctg acaaacataa tccagcaata 156180

gtcaaaacac tatcaaaagc atctagtttg atacatcagg catcaaatat acacagtgat 156240

caaatatata cagctatcac caacagttaa tcaggaactc aaatccattt aatttgatgt 156300

tggctattgg cttgctgtat attgctttga ttctgtttat gtatgtgccc tgtatccctg 156360

atttctctaa tacctttaac atgaaggggt attggatttt atcaaagtct ttttcagtgt 156420

ctaatgagat aatcatgtga ttttctttgt ttatatggtg gattatattg atgatattaa 156480

tatattgaat catctctgca tccctgggat gaagcttact tgatcatgtt ggatgatggt 156540

tttaatgtgt tctctgattc agtttgctaa tattttattg agtatttttg catcaatgtt 156600

cataaaagaa attagtctga gaatcttttg ttgagtcttt gtgtggttta ggtatcaggg 156660

tgactgtagt cacacaaaat gagtttggca gtattctttc tatttccatt ttgtggaata 156720

gtttgaggag tgttggtatt aggtcttctt tgaaagtctg gtagaattct gcactaaaac 156780

catctggccc tgggctttgg gtggaggatt gggagacttt taatgactgc ccccccacac 156840

ttaggggtta tagggctgtt taaatagttt acctgatctt gatttaactt tggtaagtgg 156900

tatctgtcta gaaaattgtc catttcactg agatttcccc gttttgtgga gtataggctt 156960

ttgaagtaag acataaaaat tcttttaatt tcatcagtgc ctgttgttat gtctcccttt 157020

tcatttctga ttttgtttac ttggatactg tctttctgtc ttttggttag tctggctaag 157080

ggtttgtcta tcttgttgat tttctcaaag aaccggctgc tggtttcatt gattatttgt 157140

actgctttct ttgtttctaa atgaatgatt ttagccccaa ttttgattat ttcctgcctt 157200

ctactactct taggtgtact tgcttctttt ttctatagct ttcaggtgta cttttttaaa 157260

cttaatttta ttttttactt attcacttta catcccactc actgccccct cccacagtcc 157320

ttcccccatc ccccttcccc ttctcctctg agcagttggg agccttcctg gctatctccc 157380

aatcctggca cttcaagtct ctgtgaagtt aggtgcttct cccactgagg ccagtcaagg 157440

gagcccagct agaagaagaa catataccac atacaggcaa cagctcttgg gatagcccct 157500

gctccagttg tttgggaccc acacaaagac caagctgcac atctgctgca catgttgggg 157560

aggcctaagt ccagcctgtg tatgttctct ttgattggtg ttcagactct gagagctcca 157620

agagtccagg ttatttgctc tgttggtctt tctgtggagt tcctatccct ttctgggcca 157680

caatccttcc tcctagtctt ccaaaagagt ccccaagctc catccactat ttggttctgg 157740

gtgtttgtat ctgtctgagt cagctgttgg gtggagcctc ccagaggaca atatgcacct 157800

gtgtgcaagc ataacagagt accattaata gtgttaggga ttggtgcttg tccataggat 157860

gggtctcaag ttgggccagt tattggatgg ccaattcctc aatctctgct ccatcccctg 157920

tccctgcatt tcttgtggac cggacagatt ttgggttgaa atttttgtgg gtgagttggt 157980

gtctctgtcg ctccactgga ttcttgcctg gcttcaggag gcaggttcca tatgcccaat 158040

tttgtgagtc acagctaagg tcactcccat tgattcttgg gtgcctccct tatcccaggt 158100

ctctgtcttg tcctggagat gccccccccc atctcctcat ccttgtcagt tgcaaagttt 158160

tttatggttt aaaatattac ttttactaaa attaaagcat gctatagaat accaccataa 158220

gatatttaga attgtgtgtg ttgtttgctt gctttgtcct tctcaatgtc tttggctatg 158280

gcaggtatca aatgaggaaa tgaaaatgat ttgtataaaa atatgctttt gataagactt 158340

tttagatgga ggagagttgc tgggtattaa accagtgcct catgcagact atttcctctg 158400

cttttgaaaa aaaaaaatct taaaaacatc tttcatccct tgtaaagctc ctaaaatgta 158460

gatatatcat atacttatct gggcaatgat ttcatctgat ttggaattct atcaatagca 158520

agtgatggtt aattcatgtc ccaaaatcaa agaggatcag gaatatatat gtggctagta 158580

ggagagatct tgcccagagt gtgagcctag aatatcacca caagcctcac agcaaaagag 158640

aaaatggctt caaactgaat cttaaatgac taaatactta acatctgaaa tgattgagaa 158700

tttgtgccta ggggaaacat agttctacat aaattataaa attattcatg gaacttgtta 158760

gaaaaaaaat ttcatgctac ataagacaca agccatgaaa accatatagc tttacagcta 158820

aaatgattta aaacaatttt taaaatactt aaaaattata aagggagaga ttggttaaga 158880

gcacaaattg ctcttccagg ggatgcagtt tctaatttcg gctaccagat ggtgactcac 158940

acctgtctgg ccacttcagt ggatctgctg ccctcttctg gccttcttga gcaccagaca 159000

tgcccatagt acacatggta ccaaacaccc atacacttaa ttttcttaat aaataaaaag 159060

aaaacctaga gtcataaata tgaaagaaaa atgattgtaa gatgaatttt tggatatttg 159120

attccatctc actttaatgt acattcccag aaatcatttt acaccctaaa aaaagggagc 159180

atatactact agatagtaaa agctttaaga gtttggaaat agatctcact gttaaagcat 159240

ttgcttagca tgcatatgac tttggattca attctcagca ctgaaagagg ctctacaaga 159300

aaggaaaata caaactgcat taagatgaga cattaaagtt catttctatc aaattcatta 159360

attatattag tctttttttt caatgctaag gattgagccc aaggaagaat tatttcactc 159420

agatgagttt tctttaaact ttgctactaa agattcaaat actgggctgg aaatatggtc 159480

tggtgacata gtgtttaccc agcatgtttg gttcctgaat ttgatcctta gtagcggcac 159540

tttcccctta agtaaccctc ccttcgagga gaggcccttg gtccggtgaa ggtcctctgc 159600

cacagtaaag gggaatgcca ggtccaggaa gtgggagtgg gtgggttggg gagcacgggg 159660

aggaaggagc ggataggggg ttttcagagg ggaagccagg aaaggggata acatttgaaa 159720

tgtaagtaaa gaaaatatct atttaccctt tcttagaaat gggaacaaaa cacccatgga 159780

aggagttaca gagacaaaat ttggagctgt gacgaaagga tggaccatct agtgattgcc 159840

atatgcaggg atccatccca taatcagctt ccaaacgctg acaccattgc atacactagc 159900

aagattttgc tgaaaggacc cagatatagc tgtctcttgt gagactatgc cggagcctag 159960

caaacacaga agtggataat cacagtcagc tattggatgg gtcatacggc ccctaatgga 160020

ggagctagag aaattaccca aggagctaaa gggaactgca accctaatag gtggaacaac 160080

aatatgaact aaccagtacc ccggagctct tgactctagc tgcatatgta tcaaaagatg 160140

gcctagtcgg ccatcactgc aaagagaggc ccattggact tgcaaacttt atatgcccca 160200

gtacagggaa atgccagggc caaaaagggg cagtgggtgg gtaggggatt gggggggggt 160260

gggtatgggg gacctttggg atagcattga aaatctaaac gaggaaaata cctaataaaa 160320

aaaaagaaaa tatctaataa aaaaaaagag taaccctccc ttcaaaaaac tcaggaagac 160380

aaaaccacta attttctttc tgaagaaaac aaatcttcaa aaccttagac aaacagtgca 160440

cacctacact ctctacctgc tgaaaagcaa gaacttcact agagcctggg aagagagcct 160500

gatcctgcat gtacttccaa attctctgcc atccctccca agaaaatcat tagtcctggg 160560

accagcacta ataggctttt gaaacttcat aacagtttat caaactttgg agacatgttt 160620

ccactggcat taagacgtgt tttactgctg ggcagtggtg gcacatgcct ttaatcccag 160680

ctctcgggag gcagaggcag gcggatttct gaatttgagg ccagcctggt ctacagagtg 160740

agttccagga cagccagggc tatacagaga aaccctatct cggaaaaaca acaacaacaa 160800

aaaagatgtg ttttactgta tgaagccagg ttcttcccac tatggaatgc ctggatctaa 160860

cttggcacac tgcgtaagca atgcattttg agaagcacag gaatcaatgt gacagacatt 160920

agaggccaac ttgtctatct gtgaagacta attggcatcg ctcctggaga tacagacaga 160980

ggttccgctt ctgttgaatg acaagtggtg gcagtagtga tatcctccag gaagcacgaa 161040

gtcctgctga acactgacaa gctagcagca aatgctgtct gtgcttgctc agctagaaca 161100

ccaccttcag cttctttgcc aatctttgcc aatcaaagat taaagaaata gtatggactc 161160

aggaggcaga ggcaggtgga tctctgagtt tgagtccagt ctggtctaca gagaatttaa 161220

ggacaacaca gagaaaccct gtcttgagga gaaaaaaagc aaagaaacca aaaagtaatg 161280

tgtatttgcc ctttgcaaaa gcatcagtgg aaaatggaaa actttagttt taaaagttct 161340

gaaggtaggt gtggtaatcg tgtacctcag cagttgtctg agagaagaca gttatatcgt 161400

gagggttata tgttgagaga cacctacagc taggtagcac cagccagaac tacatagtaa 161460

aacattgttt caaacaaaag tttctataca atttctgaag gattttcaaa gttcttacac 161520

acacacacac acacacacac acacattctt ctttcactgt tggactcatt ctagacttgg 161580

tgggttctta caatttcctc tgatattaga gaattctcta aaaaacaaat tgaaagtaag 161640

tagtggtaac acccctgtgt tcatagcact cagggggctg agacaaccgg cgtgtaagtt 161700

aaagcccaac ctggccttct taaccagacc ctatctttaa tgggctgaga gtgggtctaa 161760

aatttgaggt tattgaaaaa tgtctgaaca ctaaaactat ttgcatagca ttttgagttt 161820

gatacttgcc ccagaatagg caaaggcata taaatacaag aagggtaaaa accttgacaa 161880

aactttccca ctgaaaatga cttgggatgg gggttgccaa agatgtacaa catatttata 161940

gttttacttc tccagtaagg gaacaactaa taaagtagca gttgctacaa aaagaactaa 162000

ttctaggtct gggaaggtgg ttcattgatt aagagccctg attgctcttc ctgaggacct 162060

aagttcaact tccagctcac aaccatcggt aactggcgtt ccagggatcc aatgccttct 162120

ggcctttgta tgtactggga catggatggt gcaaagacac acatgcagac aaaagaacac 162180

atacatataa aataaaaaaa aatttaaata caaataattc tgttaggttt gttgaatgtc 162240

cacttttctt cataatcaac gtataactta taacatgtcc atttatatgt cccatgtatc 162300

tttctctgcc tgtgccccat ctaagctatg atagaacatg aggaatgagg gaaaaggaaa 162360

gggaggagaa atagaaggaa gaaatttcca acactctcgt cctttctctt ccccactttc 162420

attttattat tttgtttccc tttttcatct ccctgtccct ttaaggtgat gtcgattgta 162480

tctcaggcag gcctcaaagt tgatttgtag ccaaagatgc ccttggattt ctgatccccc 162540

tgcttccaat ttccagatgt taagattatg ggcttgtgac atctcatccc tagaaaagca 162600

taagcttgta gaagtcaagg gacactttta tttactgctg cctctctaga aacttcctgc 162660

cagtttggca cttacaaaat attttttaga aagaagagga aagtagataa tctatatact 162720

aaataagtac ttgataactg agtggaactt aaaattaaaa aaaaaaagca gtgtttgtga 162780

acaggtttca gtacctcccc atttttctca aagcaaatgg tcctggcggc tgtgtctcac 162840

acgtgggtaa tgaaatctcc ctgcctaaag atgtacaatg tgaaagtctg tttccccttg 162900

tgatagaggt taacattgta agccctgcag caccacatgg ctcaggtagt gttgtggtta 162960

aaattgtgtt tggccaaaag aaactccaac acatatatgc catcgctact tctatttttt 163020

ttcttaaaca taataaaatt taaagaaaga aaaacctcac aattgttagg atttagtggc 163080

agaaggtcct tgatgggttg gggcagagat gtgctgcaaa gagatcacac catgcaaaca 163140

gatctcagga gagaggccat ctcagagtgg ggacataaaa gagagagtta gagtcagaga 163200

gccagactga aagagacaga ctgagagact ggaagacaaa gagaatgggg gtgtgttggg 163260

gggggggttg gtaagggttt tgtaacttgt ggaaacagtg taaagagtgg catttgggga 163320

agggaggtga tgatgtgcct tttggcgctg agttcctgag ggcaggcttg acaagtgcct 163380

gctttctaac attaatggcc attgatactg gaaaaaaaaa ctattttatt actacattaa 163440

ttgaaatttg caactatatt tataaataat atttatacat ttatggagtc atgttaactt 163500

tcagcccaag gagagataac attaaaaatg aaatatattt tataaagaaa atattttctt 163560

aacctcgtaa aagtatacac agtaaactat ggttatctgt aacatttaaa gtaaataatt 163620

ttagcttaca atttaattat gatgctgatg gggtatgttc agaaagttat tcatgaaaag 163680

ttccaattcc ttacacatag attttccaac tactttcttt tgtttattca gaaaggatgg 163740

gaaactacga gggctaacac cctacctcct tgtttaaggg actgactcaa tcttctactg 163800

gagatgcccc attgcttttg acttactatg ttcattcagc cttctatttt aggtttgatt 163860

agtttgattc tacacttaac tttctcctga cataaagctc tcaataagaa agtatattca 163920

ttaacattgg cctcagaaag agagaggttt taggctgttc actggatata tgatcagaat 163980

aaaagagata caatacatac acatcagaga gagctgctgt gttggtgcca gaaattgaat 164040

ccaggtcctc tgaaagaaga gccagtgctc ttaagcacct agtactgtct tcagctccaa 164100

caagtaggtt taaatcttat tttgcaatgg gacctggtgg ctcatgcctt taatcctagg 164160

tgaatgactg tgatcttgaa ggtagcttgg tctacataat gaattccagg acagccaggg 164220

ttatgtaaaa aaaaaaaaaa atgtgtcaaa acaaaacaaa aaaaaacctt attttgggag 164280

ggaaaaattg gggtttctgt cctgacaaat ccctagcctt tctgttgaat tctttataaa 164340

aaatgtattt gtgtaaaagc tcttttgttc cttttgcacc caactctcct gcatgaaagg 164400

tcaacatgaa aatattaaaa atcacaacca agatcggatg aaatttaaat tataattact 164460

aaatgggcac atccaaatta ttatgacaga gaaaacaaaa gccctaggac tagggagatg 164520

tggaaaaatg aagcagtcat gaaatactaa aaccattctt aactgtcctt attctggaag 164580

gggaaaatca acatttccct gaaagctgct gtaatcatgt gaagttcaaa tggtttgatg 164640

agccttcctc caatcaaaca gatatgatag caactaaatt tctccaacta aattatttac 164700

aactgactga gacagtccct ctgaagccag gtactcagct aaactattca gaatgaaata 164760

ggaacggaga agagggtgga aggctctgta atgacagacc acactggaat agtagcccac 164820

tacctgactt cgtagatgtc ctgatatgat gggaatgata gacaagcatg acagtaaggt 164880

tatgaggtgg gaagaagtga gtggaattac acaaaatcta taaagaggaa gtgaagcaaa 164940

tgatgtagca agccaccctc ataggatttt gcatctgatg attgagatgg ttactaggat 165000

ctctagctat gaaatctaaa acagcttttt tggggggggg gaatcaatta cctgtagttt 165060

tatttcttgt tcatttttct ttctttgaat agcatgtttg tcctgagcca tgaaagtctc 165120

ccacatacaa accaaaagaa ggaaaaacaa acattcgata atccagttca ctgaaggaaa 165180

gtacagtggt ttaaatatgc ttaccccagg gagtggcact attagaaggt gtgccttgta 165240

gaaggaggtg tggccttgtt ggagggagcg tgttactgtg ggtgtgggct ttgagaccct 165300

ccttctagcc atgtggaaga cagtcttctc tttgccttca aaacaagatg tacaactcag 165360

ctttcccggc accatgtcat gcttcccact gtgatgataa tagcctgaac ctcagaacct 165420

gcaagtcagc ctcaattaaa cgttgtcctt tataaaagtt gccttggtca tggtttttct 165480

tcacagcaat gaaaacccta agaaagaagt gataatgaaa tttataaaga gaaataatat 165540

gtattttatg aggtatcaca tgctgtaata ttcagtagca catgaggatt gaaaattcac 165600

taaaattcag tggctacttc tggtggttct acctggaatg cttttatttt taaaagaaca 165660

tcaactcagt gcaaagtggt ttccattgtt tttatgtaac ttttctagat atgaacctct 165720

gtttcggctt tcctgtctca ccaatttgtc tctagacacc cattctacta agaaattcca 165780

cagagtgtct tatacatata ctgttttata caaggtctct attcctctat tccatacacc 165840

ccataacttg tttctctcct atttccttac aaatgaagga taaagttaaa gcaatttttg 165900

gaaaagaatt ttattctcac atgaaagcac aggttgcggc ctatgtgggt gctgcctccc 165960

ttcctcttcc tcctccccac tcctctctgg ttgccatgga gaatacagtt gatggaaaca 166020

tacaattaca agcaacgata 166040

<210> 16

<211> 475

<212> DNA

<213> 小家鼠

<220>

<221> misc_feature

<222> (330)..(330)

<223> "g" 2个选择性转录起始位点之一

<220>

<221> misc_feature

<222> (427)..(427)

<223> "a" 2个选择性转录起始位点之一

<220>

<221> misc_feature

<222> (470)..(472)

<223> 小鼠Pbsn 基因的起始密码子

<400> 16

cagtattgct gatgaatcca tggttcaggt tcaagggtgt tgaaaacttg attgaaaatg 60

gtcagacttg atattcttcc agtatatctg attggaggaa ctgataatag atatcagatt 120

taaacctcta ccattccagt taagataata tgatagcatc ttgttcttca tcttcctttt 180

tcttaatagg gacataaaac caatgaataa aaatatacct gaaacatggg ataggcactg 240

ggcattggaa atgacaataa aagtaaattt tccatcccta gtaaagttct ccaggaacct 300

atttgtatac taaatgacac aatgtcaatg tcagtgcaca actgccaact gggatgcaga 360

acactgctca cgccaaccat cctgaaagcc aactataaaa agcagagaga tactctgcac 420

cttttcagtg aggtccagat acccacagag cagagacagt cgctcacaca tgatg 475

<210> 17

<211> 4282

<212> DNA

<213> 小家鼠

<220>

<221> misc_feature

<222> (1)..(3)

<223> 小鼠Pbn基因的终止密码子

<220>

<221> misc_feature

<222> (4)..(23)

<223> 小鼠Pbn基因的3' UTR 的第1部分的外显子序列

<220>

<221> misc_feature

<222> (24)..(3768)

<223> 小鼠Pbn基因的内含子序列

<220>

<221> misc_feature

<222> (3769)..(3982)

<223> 小鼠Pbn基因的3' UTR 的第2部分的外显子序列

<220>

<221> misc_feature

<222> (3983)..(4282)

<223> 基因间序列

<400> 17

tgactcaaca agatcaggat taggtgagtc aaagcacatt aattttatat cttgaagttt 60

taattttaat tttattttaa tatttaagtt attaatattt aatatttaaa gtaaataata 120

ttttatttgt tctttatcct tttcatatat ttatataatg tatatttatc tttcatactt 180

ccacacacct catccaagca acacatctcc ctctatactt catggctttt aaattttatt 240

attatttatt attattatta cctcaatgaa tccaattggt gctatttctg aatagggtat 300

gtcaattcct ggaggcatga gtaatgtaat ataccagggc tattatgtaa tataaaaaaa 360

tggactgcag ggagctggtg gcacatgcat ttaacctagc gctcaagagg cagaagcaag 420

catatgtctg cgttttagat aaccctagtc tacagagtga gttccaggac agcaagggct 480

actcagagaa accctgtctc ataaaaccaa aaagtatatt ttttaaaggc agaagaggaa 540

aggagggagg gagggaggga aagaggcaga cagacagaca ggcaggcagg caggcaaaaa 600

gaaggaaaaa gaaaaatatg gaccctccct ctcccagaaa ctatcaactg gcaatagctc 660

tttggtgggg ggggggggtc ctgaatccct ctctgctcaa ttctagaatg ttaattagct 720

tgatctgacc agggtcttgt gcagaacacc acagttgctg tgagttcatg attgtaacag 780

atctgtcatg ttcagaaaac agaattttat ggctctactc cccatccaga tgataattga 840

tggctaagca tccacagtca cttgtcctca tcctttgacc agctacaaat ttctgcacaa 900

accactcccc actgtaaaaa gttgagcaga agtcaaacat ggaggcacac acccttaatc 960

ccaacacttg ggaggcacgg gtagatgaat ctctgtgagt atcaagccag cctgatctac 1020

atactgagct ccagaagatc caggtacata gtctctatct aaacaaacaa acacaaagtt 1080

aaaaagttga tttgaccaaa attgagagaa gcataaatct atgagtattt ttaagaccgt 1140

ggcttggaaa catgacagtt catcaccact ggtctccttc ataggctcca tgagctccat 1200

tgtcacaggc ttttgactcg aattacaata gaaacccacc cttacccctg ttcttccata 1260

gatatgaagt tccttccatg gagctggcat gaaatttaat cagagagtgc ttggctcccc 1320

aatacagcct ttattgcacc agtggacgca aggatgattt tatagtgtgt tggggaagca 1380

tggtgacatc actgacatct tatcccacat acacagccta ttaagtacat ctaagcactg 1440

tgaacgagtt tcctagtcca tttgacatcg atttcttgat gccctacagc cacagcattt 1500

ggtgtcttca gcaatagtgc cctaccattt agatatggtg tatagtcaag agatatggca 1560

atagccaagt tattttggtt attccaaggc ttccttccat taataaatat catggtggta 1620

cccccatgac taaaaattag attttcactg aataaaccat gtcttctggg aacagcatta 1680

taccattgca gggatcctct gctgaaactt ttttaatact atatttttac ttagcttaca 1740

aactagtgga tttctgtaag acttcattta ccttcagttt cagttgaccc tcccctaccc 1800

tgttcttccc tatgcccaaa cacatccaca cctactcctc tagcccacag ctctcacttt 1860

ctaatcttcc ctgtcaccag tgcccaatta tatcgcctgt attattatat tttaatcaca 1920

caaccatagg tttccatatg aggttttaat aacccttcat tctggttaaa ccttccacca 1980

caccctgatt tccccattcc acaaccaact ccatgattaa gccttcctgc cccaagtatt 2040

cttctttata cttcatttta atggcattac atttgatgga cccacttcct tgatggaccc 2100

aattcaaacc agtttctaat tacctggatt ccttacatac tccatattat gcatacaaaa 2160

taaaagattc aagtctaatg tccacatgtg agatagaatg tgcagtttgt ctttctgagc 2220

ctgagtggcc tcattaagta taataatttc cagttccttc tatttacttg gaaatttcat 2280

attttcattg ttctctatgg ctgagtaata ttccatctta tacattacat tttccttatc 2340

cattcattag ttgatgaaca gttgggtcaa cttcgtttct tagctattat gaacttaacc 2400

tcagtgagca tggacattca aaggtctctg taacagaata taaacccctt tgtgtacata 2460

tctagaaatg gaggaactag agaaagcacc caaggaacta aagggaactg caaccctata 2520

ggtggaacaa caatatgaac taagcagtac cccggagctc ttgtctctag ctgcatatct 2580

atcaaaagat ggcctagtcg gccatcactg caaagagagg cccattggac ttgcaaactt 2640

tatatgcccc agtacagggg aatgccaggg ccaaaaaggg gggatgggtg ggtaggggag 2700

tggggggggg ttggggactt tttgtatagc attggaaatg taaatgagct aaatacctaa 2760

taaaaaatgg aaaaaaaaag aaatggtgta actgagtcac atgggaagtc tttttctaat 2820

ctttggattt gtttatttga tgttcatagt ttttgggttt tggttggttt tgttctaagt 2880

tctttgtata ttgtagacac taatcctcca tcacatgtgt agttggcaaa gatctccatt 2940

ccccgagata cctgtgcatt taattgacag cttcctttgc cgtagttttt aattccatga 3000

tatctgacaa gtgtttgtct tactttcttg ctacaagaat cctattcaaa gaatccatac 3060

ctgtgtctat ggttaacaca cactccatgc tttcttctct atcagcttca ggttaccatg 3120

tcttatgaca cggtctttga atcatttgga gttgaggttt ttttcaaggt gacagggaag 3180

agcccaggtt catttctctg tatcctgatg tccacttttt cctattcggt ctatttatgg 3240

aattatatat ttttatgtta ggtcattttt cagtggaggc attaacaata tccagaaggg 3300

gactatttct tactagtgtt gagatggtat tctcctatat ggggctggta ctgaaggcag 3360

caagttctac ccctagtctt cctgtgagat tcaactacta tctgggacct cgagtgagac 3420

tctgtctgta ggatacatgg ggcttggtaa actccaatgt gaaacaaaaa atatataatt 3480

ttagtttaga ttcatagaaa ctacatcctc aaataaacac ataagttcta aaaagtacca 3540

atttaggtct tgatataaga tcatttgtca tataaaaatt ttccatataa ggaaaatttc 3600

catacaaagt tcatgtatat ttccaaatat acaaaattct gtaaaatgtt tttgcatgat 3660

acatcttgtc attgtttgcc tctttaatgg cttgtatttg tttcattttc tactctcatc 3720

aaatatcatg tattactatc ctaaatatat gaaataattc tgttccagca ttacagatga 3780

catcaggaat tttccagtat atttttcctg gaacctgaaa catcaatatg aagatgaagc 3840

aatcttgtct ctcagatcat attttcctat ttattgcaaa ttacaattcc tgtctctgta 3900

ctttctcttt cactcattgt ttcccatgtt ctaatcggta ttagtgcatc tttgaatgtt 3960

taaataaatt tattttactt gcatacgtgt tgttaaaagg ggaagctaaa gtacaatgca 4020

cataaatacc tatttgactt tttttaaagg agaggagggt tggaggggtg gcatgtgatt 4080

gctcacgcct gtaatttcag caccggggaa agaggtagag acagttgaat cctctgatgt 4140

caccagtagc cagcctagac tacatgaaat attgcaggcc agtgagagat catcccagaa 4200

aacaaggcag ggacatgaca ggcagctcag tggtcaagag cactagctgc tcttccacag 4260

gacctgggtt atattcctaa ca 4282

Claims (45)

1.一种啮齿动物，其在基因组中包含转基因，所述转基因包含：

(a)小鼠probasin基因的5'调控区，

(b)核酸，其包含编码致癌蛋白的第一核苷酸序列，以及

(c)所述小鼠probasin基因的3'调控区，

其中所述5'调控区、所述核酸和所述3'调控区彼此可操作地连接。

2.根据权利要求1所述的啮齿动物，其中所述5'调控区包含在所述小鼠probasin基因的转录起始位点上游的至少5kb的核酸序列。

3.根据权利要求1所述的啮齿动物，其中所述5'调控区包含在所述小鼠probasin基因的转录起始位点上游的至少10kb的核酸序列。

4.根据权利要求1所述的啮齿动物，其中所述5'调控区包含在所述小鼠probasin基因的转录起始位点上游的至少25kb的核酸序列。

5.根据权利要求1所述的啮齿动物，其中所述5'调控区包含所述小鼠probasin基因的5'非翻译区(UTR)。

6.根据权利要求1所述的啮齿动物，其中所述5'调控区包含如SEQ ID NO:6中列出的核苷酸序列。

7.根据权利要求1-6中任一项所述的啮齿动物，其中所述3'调控区包含在所述小鼠probasin基因的转录终止位点下游的至少5kb的核酸序列。

8.根据权利要求1-6中任一项所述的啮齿动物，其中所述3'调控区包含在所述小鼠probasin基因的转录终止位点下游的至少25kb的核酸序列。

9.根据权利要求1-6中任一项所述的啮齿动物，其中所述3'调控区包含在所述小鼠probasin基因的转录终止位点下游的至少50kb的核酸序列。

10.根据权利要求1-6中任一项所述的啮齿动物，其中所述3'调控区包含所述小鼠probasin基因的3'非翻译区(UTR)。

11.根据权利要求1-6中任一项所述的啮齿动物，其中所述3'调控区包含如SEQ ID NO:7中列出的核苷酸序列。

12.根据权利要求1-11中任一项所述的啮齿动物，其中所述致癌蛋白包括SV40肿瘤抗原或Myc。

13.根据权利要求12所述的啮齿动物，其中所述SV40肿瘤抗原包括SV40大T抗原或其功能活性片段。

14.根据权利要求12所述的啮齿动物，其中所述SV40肿瘤抗原包括SV40小t抗原或其功能活性片段。

15.根据权利要求1-11中任一项所述的啮齿动物，其中所述第一核苷酸序列编码SV40大T抗原或其功能活性片段，并且还编码SV40小t抗原或其功能活性片段。

16.根据权利要求1-11中任一项所述的啮齿动物，其中所述第一核苷酸序列包括如SEQID NO:1中列出的序列。

17.根据权利要求1-16中任一项所述的啮齿动物，其中所述核酸还包含编码报告子的第二核苷酸序列。

18.根据权利要求17所述的啮齿动物，其中所述报告子是荧光素酶。

19.根据权利要求17或18所述的啮齿动物，其中所述第一核苷酸序列经由编码2A肽的第三核苷酸序列在框内与所述第二核苷酸序列连接。

20.根据权利要求19所述啮齿动物，其中所述2A肽选自由以下项组成的组：包含SEQ IDNO:10的氨基酸序列的F2A肽、包含SEQ ID NO:11的氨基酸序列的E2A肽、包含SEQ ID NO:12的氨基酸序列的P2A肽以及包含SEQ ID NO:13的氨基酸序列的T2A肽。

21.根据权利要求19所述的啮齿动物，其中所述2A肽是包含SEQ ID NO:13的氨基酸序列的T2A肽。

22.根据权利要求1-21中任一项所述的啮齿动物，其中所述核酸还包含编码选择性标记的第四核苷酸序列，所述第四核苷酸序列可操作地连接至在所述啮齿动物细胞中具有活性的启动子。

23.根据权利要求1-22中任一项所述的啮齿动物，其中所述转基因被整合在所述基因组的异位基因座处。

24.根据权利要求23所述的啮齿动物，其中所述转基因的至少一至十个拷贝被串联整合在所述异位基因座处。

25.根据权利要求1-24中任一项所述的啮齿动物，其中所述啮齿动物是小鼠或大鼠。

26.根据权利要求1-24所述的方法，其中所述啮齿动物是小鼠。

27.根据权利要求26所述的啮齿动物，其中所述小鼠是选自由以下项组成的组的品系：C57BL/6品系、129品系或其杂交体。

28.根据权利要求27所述的啮齿动物，其中所述小鼠是F1H4品系。

29.根据权利要求1-28中任一项所述的啮齿动物，其中所述致癌蛋白特异性地表达在前列腺中。

30.根据权利要求29所述的啮齿动物，其中所述致癌蛋白表达在前列腺的背外侧叶、前叶，或背外侧和前叶中。

31.根据权利要求1-30中任一项所述的啮齿动物，其中所述啮齿动物的特征在于选自由以下项组成的组的至少一种表型：(i)所述啮齿动物在至少约2月龄后开始在前列腺组织中显示前列腺上皮内瘤形成(PIN)；(ii)所述啮齿动物在前列腺的背外侧叶，或背外侧叶和前叶中显示PIN；(iii)所述啮齿动物基本上在前列腺的背外侧叶、前叶，或背外侧叶和前叶两者中，但基本上不在前列腺的腹侧叶中显示PIN；(iv)所述啮齿动物在至少约6月龄后开始显示腺癌；(v)所述啮齿动物在前列腺的背外侧叶、前叶，或背外侧叶和前叶两者中显示腺癌；(vi)所述啮齿动物基本上在前列腺的背外侧叶、前叶，或背外侧叶和前叶两者中，但基本上不在前列腺的腹侧叶中显示腺癌。

32.根据权利要求31所述啮齿动物，其中所述啮齿动物在约4-6月龄时开始显示PIN。

33.根据权利要求31所述啮齿动物，其中所述啮齿动物在约7-9月龄时开始显示腺癌。

34.根据权利要求31或33所述的啮齿动物，其中所述腺癌不是神经内分泌癌。

35.根据权利要求1所述的啮齿动物，其中腺癌显示在前列腺中并且其中所述腺癌不是神经内分泌癌。

36.根据权利要求31所述的啮齿动物，其中所述啮齿动物在约4-6月龄时开始在前列腺的背外侧叶和/或前叶中显示PIN，并且在约7-9月龄时开始在前列腺的背外侧叶和/或前叶中显示腺癌。

37.一种根据权利要求1-36中任一项所述的啮齿动物的分离细胞或组织。

38.一种啮齿动物胚胎干(ES)细胞，其在基因组中包含转基因，其中所述转基因包含：

(a)小鼠probasin基因的5'调控区，

(b)核酸，其包含编码致癌蛋白的第一核苷酸序列，以及

(c)小鼠probasin基因的3'调控区，

其中所述5'调控区、所述核酸和所述3'调控区彼此可操作地连接。

39.根据权利要求38所述的啮齿动物ES细胞，其中所述啮齿动物ES细胞是小鼠ES细胞或大鼠ES细胞。

40.根据权利要求38所述的啮齿动物ES细胞，其中所述致癌蛋白包括SV40肿瘤抗原或Myc。

41.一种制备前列腺癌的啮齿动物模型的方法，其包括：

(a)将转基因引入到啮齿动物ES细胞中，所述转基因包含：

(i)小鼠probasin基因的5'调控区，

(ii)核酸，其包含编码致癌蛋白的第一核苷酸序列，以及

(iii)所述小鼠probasin基因的3'调控区，

其中所述5'调控区、所述核酸和所述3'调控区可操作地连接；

(b)选择在所述基因组中包含所述转基因的修饰啮齿动物ES细胞；

(c)在桑椹胚前期时将所述修饰啮齿动物ES细胞引入到所述啮齿动物的宿主胚胎中；

(d)将所述宿主胚胎植入到代理孕母体中；以及

(e)获得所述前列腺癌的啮齿动物模型。

42.根据权利要求41所述的方法，其中所述转基因被整合到异位基因座中。

43.根据权利要求41所述的方法，其中所述啮齿动物是小鼠或大鼠。

44.根据权利要求41所述的方法，其中所述致癌蛋白包括SV40肿瘤抗原或Myc。

45.根据权利要求41所述的方法，其中所述致癌蛋白特异性地表达在所述啮齿动物的前列腺中。