CN108125729B - Filter device - Google Patents
Filter device Download PDFInfo
- Publication number
- CN108125729B CN108125729B CN201611100693.7A CN201611100693A CN108125729B CN 108125729 B CN108125729 B CN 108125729B CN 201611100693 A CN201611100693 A CN 201611100693A CN 108125729 B CN108125729 B CN 108125729B
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- China
- Prior art keywords
- connecting rod
- filter screen
- rod
- filter
- strainer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000007704 transition Effects 0.000 claims description 5
- 230000007423 decrease Effects 0.000 claims description 3
- 210000004204 blood vessel Anatomy 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 5
- 210000001339 epidermal cell Anatomy 0.000 abstract description 3
- 208000010378 Pulmonary Embolism Diseases 0.000 description 5
- 210000002889 endothelial cell Anatomy 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000010276 construction Methods 0.000 description 3
- 208000007536 Thrombosis Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000000994 depressogenic effect Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 210000003989 endothelium vascular Anatomy 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 210000001631 vena cava inferior Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
- A61F2/0108—Both ends closed, i.e. legs gathered at both ends
Landscapes
- Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
Abstract
The invention discloses a filter, which comprises a far-end filter screen, a near-core filter screen, a connecting rod and at least one supporting rod, wherein the connecting rod is connected with the far-end filter screen and the near-core filter screen, and the supporting rod is connected with the connecting rod and is positioned outside the connecting rod. The radial cross-sectional area of a portion of the connecting rod is smaller than the radial cross-sectional area of the other portion of the connecting rod. The telecentric end filter screen comprises a plurality of telecentric end filter screen rods, one end of each telecentric end filter screen rod is connected with the connecting rod, and the other ends of all telecentric end filter screen rods are converged at the telecentric end. The connecting rod of the filter is provided with the flexible section, the radial sectional area of part of the flexible section is smaller than that of the rest part of the connecting rod, so that the effect of changing and increasing the local deflection of the connecting rod is achieved, and the flexible section connecting rod bends towards the inside of the filter under the condition that the filter is subjected to radial pressure from the wall of a lumen, so that the connecting rod is far away from the wall of the blood vessel, the risk that the connecting rod is covered by epidermal cells is reduced, and the filter is easier to take out.
Description
Technical Field
The invention relates to a cardiovascular medical instrument, in particular to a vena cava filter.
Background
Pulmonary embolism is a high mortality disease, and the causes of the pulmonary embolism are from various emboli of the systemic circulation, such as thrombus shedding. The vena cava filter (hereinafter referred to as filter) is clinically proved to be a safe and effective means for preventing pulmonary embolism, and can reduce the incidence rate of the pulmonary embolism. After the filter is implanted into the inferior vena cava for a certain time, the filter can be coated and wrapped by endothelial cells to different degrees, so that the filter is difficult to take out; the filter is in long-term contact with blood and vascular endothelium, protein adsorption and platelet adhesion can occur, and finally thrombus is formed to cause venous vessel blockage or pulmonary embolism to occur again; and even risk deforming, tilting, shifting, breaking the filter, or even penetrating the blood vessel.
Therefore, how to avoid the filter from being coated and wrapped by endothelial cells in the blood vessel and make the filter be easily taken out is a problem to be solved.
Disclosure of Invention
The technical problem to be solved by the present invention is to provide a filter which can avoid being covered by endothelial cells and can be easily taken out, aiming at the defects of the prior art.
The technical scheme adopted by the invention for solving the technical problems is as follows: constructing a filter, which comprises a far-end filter screen, a near-end filter screen, a connecting rod for connecting the far-end filter screen and the near-end filter screen, and at least one supporting rod connected with the connecting rod and positioned outside the connecting rod, wherein the far-end filter screen comprises a plurality of far-end filter screen rods, and the other ends of all the far-end filter screen rods are converged at the far end; the connecting rod has at least a portion having a rigidity lower than that of the remaining portion of the connecting rod, and is depressed toward the inside of the strainer when the supporting rod is pressed radially toward the strainer.
In an embodiment of the invention, a radial cross-sectional area of a portion of the connecting rod is smaller than a radial cross-sectional area of other portions of the connecting rod.
According to an embodiment of the present invention, the connecting rod is provided with a groove formed by material removal, and the groove and the connecting rod are in smooth transition.
According to an embodiment of the present invention, the groove is located at an outer side of the connecting rod and/or an inner side of the connecting rod.
According to an embodiment of the present invention, the groove is a U-shaped groove, a V-shaped groove or an arc-shaped groove.
In an embodiment of the present invention, the connecting rod is provided with a linear cut.
According to an embodiment of the present invention, the linear cuts include continuous or discontinuous cuts.
According to an embodiment of the present invention, the radial cross-sectional area of the connecting rod is gradually reduced along the axial direction thereof.
In an embodiment of the invention, the support rods include a distal end support rod disposed near the distal end and a proximal end support rod disposed near the proximal end.
In an embodiment of the invention, each of the distal end support rod and the proximal end support rod includes a guide section extending from the connection rod to the blood vessel wall and a support section extending from the guide section and abutting against the blood vessel wall.
In an embodiment of the invention, the distal support rod further comprises a fixation anchor extending from the junction of the guide section and the support section toward the vessel wall.
The connecting rod of the filter has lower rigidity in one part than in other parts, and when the supporting rod is subjected to radial pressure, the connecting rod is sunken towards the inside of the filter, so that the connecting rod is far away from the blood vessel wall, the risk of the connecting rod being covered by epidermal cells is reduced, and the filter is easier to take out.
Drawings
The invention will be further described with reference to the accompanying drawings and examples, in which:
FIG. 1 is a schematic diagram of the construction of a preferred embodiment of a strainer of the present invention;
FIG. 2a is a schematic view of a first embodiment of a connecting rod in the colander of the present invention;
FIG. 2b is an enlarged view of the area indicated by reference numeral 151 in FIG. 2 a;
FIG. 3a is a schematic structural view of a second embodiment of a connecting rod in the colander of the present invention;
FIG. 3b is an enlarged view of the area indicated at 152 in FIG. 3 a;
FIG. 4a is a schematic structural view of a third embodiment of a connecting rod in the colander of the present invention;
FIG. 4b is an enlarged view of the area marked 153 in FIG. 4 a;
FIG. 5a is a schematic structural view of a fourth embodiment of a connecting rod in the colander of the present invention;
FIG. 5b is an enlarged view of the area referenced 154 in FIG. 5 a;
FIG. 6a is a schematic representation of the structure of a fifth embodiment of the connecting rod in the colander of the present invention;
FIG. 6b is an enlarged view of the area referenced 154 in FIG. 6 a;
FIG. 7a is a schematic structural view of a sixth embodiment of a connecting rod in the colander of the present invention;
FIG. 7b is an enlarged view of the area indicated by reference numeral 155 in FIG. 7 a;
fig. 8 is a schematic view of the deformation of the filter of the present invention within a blood vessel after implantation.
Detailed Description
For a more clear understanding of the technical features, objects and effects of the present invention, embodiments of the present invention will now be described in detail with reference to the accompanying drawings.
The first embodiment:
as shown in fig. 1, a filter 10 includes a distal end 11, a proximal end 12, and a filter body connected between the distal end 11 and the proximal end 12. Distal end 11 is provided with a coupling nut 19 and a retrieval hook 18. The retrieval hook 18 is intended for use with a capture device and comprises a plurality of hooks 181 evenly spaced circumferentially about the distal end 11, each hook 181 extending radially in a direction toward the filter body. The plurality of barbs 181 are circumferentially disposed about distal end 11 to facilitate retrieval of the filter, and even if the lumen wall occludes one of barbs 181 due to tilting of the filter, the remaining barbs 181 are exposed to the lumen, thereby increasing the chance of filter capture. It will be appreciated that a retrieval hook may also be provided on the proximal end 12 to enable the filter to be captured and retrieved in both directions.
The strainer body includes a distal strainer 13, a proximal strainer 14, and a connecting rod 15 for connecting the distal strainer 13 and the proximal strainer 14. The plurality of connecting rods 15 are arranged at intervals circumferentially around a connecting line between the distal end 11 and the proximal end 12. The distal end filter screen 13 and the proximal end filter screen 14 are integrally in a conical mesh structure. The distal end filter screen 13 comprises a plurality of distal end filter screen rods 131, the distal end filter screen rods 131 extend from one end of the connecting rod to the distal end 11, and two adjacent distal end filter screen rods 131 are connected with the distal end 11 after being collected at a position close to the distal end 11. The proximal screen 14 includes a plurality of Y-shaped proximal screen bars 141, each Y-shaped proximal screen bar 141 includes a first screen bar 142 and a second screen bar 143 formed by branching from the end of the first screen bar 142 and connected to the connecting rod 15, and the plurality of first screen bars 142 converge at the proximal end 12.
As shown in fig. 2a, the filter further comprises a support rod connected with the connecting rod 15, the support rod is used for abutting against the inner wall of the lumen, so that the connecting rod 15 is far away from the inner wall of the lumen without contacting the inner wall of the lumen, the risk that the connecting rod 15 is climbed by endothelial cells of blood vessels is reduced, the support rod can ensure that the whole filter is stressed in the axial direction and the circumferential direction in a balanced manner, and the whole filter is prevented from inclining or shifting under the influence of blood flow and external force. The support rods include a distal support rod 16 disposed proximate the distal end 11 and a proximal support rod 17 disposed proximate the proximal end 12. Wherein the distal end support rod 16 includes a guide segment 161 extending from the connecting rod 15 in a direction away from the distal end 11, a support segment 162 extending from the guide segment 161 in a bent manner, and a fixing anchor 163 extending from a connecting portion of the guide segment 161 and the support segment 162. The proximal support rods 17 are substantially identical in construction to the distal support rods 16, except that there are no anchors. In other embodiments of the present invention, the proximal support rods 17 may have the same configuration as the distal support rods 16.
The connecting rod 15 in the present invention has a portion with a rigidity smaller than that of the remaining portion. As shown in fig. 2a and 2b, in the present embodiment, the rigidity of the middle portion of the connecting rod 15 is reduced by removing the material to form a groove 151 in the portion. The groove 151 is located on the outside of the connecting rod 15, and it is noted that, in the present invention, the one facing the inside of the strainer body is the inside, and the other facing the outside. The grooves 151 formed by the blanking make the radial cross-sectional area of the connecting rod 15 at this location smaller than the radial cross-sectional area of the rest of the connecting rod 15, reducing the stiffness of this part and thus increasing the deflection of the connecting rod 15. As shown in fig. 8, when the filter 10 is completely released from the conveyor in the blood vessel, the support rod is subjected to a radial pressure from the lumen wall 20, or when a radial pressure is applied to the support rod in vitro, the pressure is transmitted to the connecting rod 15, and since the radial sectional area of the groove 151 is smaller than that of the rest of the connecting rod 15, the middle portion of the connecting rod 15 is relatively soft, so that the middle portion of the connecting rod 15 is bent toward the inside of the filter 10, a recess is generated, the connecting rod is further away from the lumen wall 20, the risk of the connecting rod 15 being climbed is reduced, and the ease of taking out the filter is improved.
In this embodiment, the groove 151 is U-shaped and has a smooth transition, specifically a chamfered transition, with the connecting rod 15, and it will be appreciated that a rounded transition may also be used, so as to reduce the stress in this portion, so that the connecting rod 15 is not easily broken due to the abrupt change in the radial cross-sectional area of this portion.
Second embodiment:
as shown in fig. 3a and 3b, the structure of the strainer in this embodiment is substantially the same as that of the previous embodiment except that, in this embodiment, the grooves 152 are provided on the inner side of the connecting rods 15. It follows that the groove 152 can be provided both on the inside and on the outside of the connecting rod 15, with the same effect. When the struts are subjected to radial pressure, the middle portion of the connecting rod 15 will still bend towards the inside of the filter, creating a depression, and thus moving further away from the lumen wall.
The third embodiment:
as shown in fig. 4a and 4b, the structure of the strainer of the present embodiment is substantially the same as the above two embodiments, except that, in the present embodiment, the grooves 153 are provided on the inner and outer sides of the connecting rod 15, at which time the cross-sectional area of the connecting rod 15 at this portion is minimized, and the connecting rod 15 of the present embodiment is more flexible and more easily bent and deformed than the above two embodiments.
The fourth embodiment:
the strainer of this embodiment is constructed substantially the same as the two embodiments above, except that in this embodiment, the grooves 154 are V-shaped grooves formed by the removal of the tie rods 15, as shown in fig. 5a and 5 b. And as with the previous embodiments, the V-shaped groove 154 may be disposed on the inside, outside, or both the inside and outside of the connecting rod 15.
Fifth embodiment:
as shown in fig. 6a and 6b, the structure of the strainer in this embodiment is substantially the same as that in the above two embodiments, except that in this embodiment, a linear cut 155 is provided on the connecting rod 15. The cut 155 is formed by removing material from the surface of the tie rod 15, so that the radial cross-sectional area of the portion having the cut is necessarily smaller than the radial cross-sectional area of the remaining portion of the tie rod 15, the former being less rigid than the latter. This removal is only to a lesser extent than in the previous embodiments, with less variation in the radial section of the tie-rod 15, but even so, when the support rod is in the fully released state and is subjected to radial pressure, the presence of the score 155 increases the flexibility of the tie-rod 15 to some extent, guiding the intermediate portion of the tie-rod 15 to bend towards the inside of the filter, thus moving away from the inner wall of the lumen. The cutting mark 155 has the advantage of increasing the deflection of the connecting rod 15 on the premise of not influencing the strength of the connecting rod 15 to the maximum extent.
The cutting marks 155 may be continuous cutting marks or discontinuous cutting marks, and a plurality of cutting marks may be provided at intervals on the basis of the continuous cutting marks, so as to further increase the flexibility of the connecting rod 155.
Sixth embodiment:
the construction of the strainer of this embodiment is substantially the same as the two embodiments above, except that in this embodiment the radial cross-sectional area of the connecting rods 15 decreases in a proximal to distal direction, as shown in fig. 7a and 7 b. In other embodiments, the radial cross-sectional area of the connecting rod 15 may also gradually decrease from the distal end to the proximal end, as long as it is in the axial direction, which does not affect the implementation of the present patent.
The gradual reduction of the radial sectional area of the connecting rod 15 can increase the deflection of the connecting rod 15 and simultaneously reserve the strength of the connecting rod 15 to the maximum extent.
The above are only a few specific examples of the present invention, which should not limit the implementation of the present invention. For example, the groove of the present invention may have other shapes, such as an arc-shaped groove, etc., as long as it has the effect of reducing the radial sectional area of the connecting rod portion; further, without being limited to the grooves and the cuts, it is sufficient that the rigidity of a portion of the connecting rod can be reduced and the middle portion of the connecting rod can be depressed toward the inside of the strainer when the support rods are subjected to radial pressure, and can be located closer to the central axis of the strainer than the distal and proximal end portions. Such measures include the use of softer materials in certain parts of the connecting rod, the use of other machining methods to increase the flexibility of the connecting rod, etc.
The connecting rod of the filter has the advantages that at least part of the rigidity of the connecting rod is lower than the rigidity of other parts, so that the effect of increasing the flexibility of the connecting rod is achieved, and when the filter is subjected to radial pressure from the wall of a lumen, the connecting rod bends towards the inside of the filter, so that the connecting rod is far away from the wall of the blood vessel, the risk that the connecting rod is covered by epidermal cells in a creeping mode is reduced, and the filter is easier to take out.
Claims (11)
1. A filter comprises a far-end filter screen, a near-end filter screen, a connecting rod for connecting the far-end filter screen and the near-end filter screen, and at least one supporting rod which is connected with the connecting rod and is positioned outside the connecting rod, wherein the far-end filter screen comprises a plurality of far-end filter screen rods, and the other ends of all the far-end filter screen rods are converged at the far end; characterized in that at least part of the connecting rod has a rigidity lower than the rigidity of the rest of the connecting rod, and the connecting rod is entirely recessed toward the inside of the strainer when the supporting rod is pressed radially toward the strainer.
2. A strainer according to claim 1 wherein a portion of said connecting rods has a radial cross-sectional area less than the radial cross-sectional area of other portions of the connecting rods.
3. The strainer of claim 2 wherein the connecting rods are provided with stock removing pockets with smooth transitions between the pockets and the connecting rods.
4. A strainer according to claim 3 wherein said grooves are located outside the connecting rods and/or inside the connecting rods.
5. The strainer of claim 3 wherein the grooves are U-shaped grooves, V-shaped grooves, or arcuate grooves.
6. The strainer of claim 1 wherein the tie bars are provided with linear cuts.
7. The filter of claim 6, wherein the linear cuts comprise continuous or non-continuous cuts.
8. A strainer according to claim 1 wherein the radial cross-sectional area of the connecting rods decreases progressively in the axial direction thereof.
9. The filter of claim 1, wherein the support rods comprise a distal support rod disposed proximate the distal end and a proximal support rod disposed proximate the proximal end.
10. The filter of claim 9, wherein the distal support rod and the proximal support rod each include a guide segment extending from the connector rod toward the vessel wall and a support segment extending from the guide segment and curving and abutting the vessel wall.
11. The filter of claim 10, wherein the distal support rod further comprises a fixation anchor extending from the junction of the guide section and the support section toward the vessel wall.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611100693.7A CN108125729B (en) | 2016-12-01 | 2016-12-01 | Filter device |
| PCT/CN2017/099025 WO2018099147A1 (en) | 2016-12-01 | 2017-08-25 | Filter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611100693.7A CN108125729B (en) | 2016-12-01 | 2016-12-01 | Filter device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108125729A CN108125729A (en) | 2018-06-08 |
| CN108125729B true CN108125729B (en) | 2020-10-27 |
Family
ID=62242698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611100693.7A Active CN108125729B (en) | 2016-12-01 | 2016-12-01 | Filter device |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN108125729B (en) |
| WO (1) | WO2018099147A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108992202A (en) * | 2018-08-14 | 2018-12-14 | 内蒙古工业大学 | A kind of not damaged retrievable vena cava filter |
| CN113940784A (en) * | 2020-07-15 | 2022-01-18 | 先健科技(深圳)有限公司 | Thrombus interception instrument |
| CN113940783A (en) * | 2020-07-15 | 2022-01-18 | 先健科技(深圳)有限公司 | thrombus blocking device |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1711978A (en) * | 2004-06-25 | 2005-12-28 | 深圳市先健科技股份有限公司 | Latching of left auricular appendix and conveyor thereof |
| CN101031254A (en) * | 2004-09-27 | 2007-09-05 | 库克公司 | Removable vena cava filter comprising struts having axial beds |
| CN204181741U (en) * | 2014-10-13 | 2015-03-04 | 陈奕龙 | Vena cava filter |
| CN204909721U (en) * | 2015-06-30 | 2015-12-30 | 先健科技(深圳)有限公司 | Filter |
| CN105662646A (en) * | 2015-12-29 | 2016-06-15 | 先健科技(深圳)有限公司 | Filter |
| CN105796207A (en) * | 2014-12-30 | 2016-07-27 | 先健科技(深圳)有限公司 | Filter and making method thereof |
| CN206761794U (en) * | 2016-12-01 | 2017-12-19 | 先健科技(深圳)有限公司 | Filter |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008077067A2 (en) * | 2006-12-19 | 2008-06-26 | C.R. Bard Inc. | Inferior vena cava filter with stability features |
| CN106308974B (en) * | 2015-06-30 | 2018-08-03 | 先健科技(深圳)有限公司 | Filter |
-
2016
- 2016-12-01 CN CN201611100693.7A patent/CN108125729B/en active Active
-
2017
- 2017-08-25 WO PCT/CN2017/099025 patent/WO2018099147A1/en active Application Filing
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1711978A (en) * | 2004-06-25 | 2005-12-28 | 深圳市先健科技股份有限公司 | Latching of left auricular appendix and conveyor thereof |
| CN101031254A (en) * | 2004-09-27 | 2007-09-05 | 库克公司 | Removable vena cava filter comprising struts having axial beds |
| CN204181741U (en) * | 2014-10-13 | 2015-03-04 | 陈奕龙 | Vena cava filter |
| CN105796207A (en) * | 2014-12-30 | 2016-07-27 | 先健科技(深圳)有限公司 | Filter and making method thereof |
| CN204909721U (en) * | 2015-06-30 | 2015-12-30 | 先健科技(深圳)有限公司 | Filter |
| CN105662646A (en) * | 2015-12-29 | 2016-06-15 | 先健科技(深圳)有限公司 | Filter |
| CN206761794U (en) * | 2016-12-01 | 2017-12-19 | 先健科技(深圳)有限公司 | Filter |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018099147A1 (en) | 2018-06-07 |
| CN108125729A (en) | 2018-06-08 |
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