CN108079017B - Hypochlorous acid wound disinfectant containing antibacterial polysaccharide compounds or derivatives - Google Patents
Hypochlorous acid wound disinfectant containing antibacterial polysaccharide compounds or derivatives Download PDFInfo
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- CN108079017B CN108079017B CN201711204955.9A CN201711204955A CN108079017B CN 108079017 B CN108079017 B CN 108079017B CN 201711204955 A CN201711204955 A CN 201711204955A CN 108079017 B CN108079017 B CN 108079017B
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- hypochlorous acid
- antibacterial polysaccharide
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 79
- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 69
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 69
- 239000000645 desinfectant Substances 0.000 title claims abstract description 60
- -1 polysaccharide compounds Chemical class 0.000 title claims abstract description 60
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 title claims abstract description 58
- 239000005708 Sodium hypochlorite Substances 0.000 claims abstract description 15
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 claims abstract description 15
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 claims abstract description 9
- HPEWZLCIOKVLBZ-UHFFFAOYSA-N barium hypochlorite Chemical compound [Ba+2].Cl[O-].Cl[O-] HPEWZLCIOKVLBZ-UHFFFAOYSA-N 0.000 claims abstract description 7
- SATVIFGJTRRDQU-UHFFFAOYSA-N potassium hypochlorite Chemical compound [K+].Cl[O-] SATVIFGJTRRDQU-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229920001661 Chitosan Polymers 0.000 claims description 18
- LEAHFJQFYSDGGP-UHFFFAOYSA-K trisodium;dihydrogen phosphate;hydrogen phosphate Chemical compound [Na+].[Na+].[Na+].OP(O)([O-])=O.OP([O-])([O-])=O LEAHFJQFYSDGGP-UHFFFAOYSA-K 0.000 claims description 13
- 150000004676 glycans Chemical class 0.000 claims description 10
- 239000000872 buffer Substances 0.000 claims description 9
- 229920002678 cellulose Polymers 0.000 claims description 8
- 239000001913 cellulose Substances 0.000 claims description 8
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 6
- 239000001632 sodium acetate Substances 0.000 claims description 6
- 235000017281 sodium acetate Nutrition 0.000 claims description 6
- 235000016337 monopotassium tartrate Nutrition 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- KYKNRZGSIGMXFH-ZVGUSBNCSA-M potassium bitartrate Chemical compound [K+].OC(=O)[C@H](O)[C@@H](O)C([O-])=O KYKNRZGSIGMXFH-ZVGUSBNCSA-M 0.000 claims description 5
- 229940086065 potassium hydrogentartrate Drugs 0.000 claims description 5
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 4
- 239000004327 boric acid Substances 0.000 claims description 4
- 229920001612 Hydroxyethyl starch Polymers 0.000 claims description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 3
- 229940050526 hydroxyethylstarch Drugs 0.000 claims description 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- BHZOKUMUHVTPBX-UHFFFAOYSA-M sodium acetic acid acetate Chemical compound [Na+].CC(O)=O.CC([O-])=O BHZOKUMUHVTPBX-UHFFFAOYSA-M 0.000 claims description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 3
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- XTEGARKTQYYJKE-UHFFFAOYSA-N chloric acid Chemical compound OCl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-N 0.000 claims 1
- 229940005991 chloric acid Drugs 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 230000007794 irritation Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 30
- 206010052428 Wound Diseases 0.000 description 17
- 208000027418 Wounds and injury Diseases 0.000 description 17
- 239000007853 buffer solution Substances 0.000 description 17
- 239000002105 nanoparticle Substances 0.000 description 5
- 230000001954 sterilising effect Effects 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 230000003385 bacteriostatic effect Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 230000002421 anti-septic effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
一种含有抗菌多糖类化合物或衍生物的次氯酸伤口消毒液，属于消毒液技术领域。包括按质量份数次氯酸（HClO）1份～5份，其特征在于：还包括按质量份数次氯酸钠溶液1份～3份或次氯酸钙1份～2份或次氯酸钾1份～2份或次氯酸钡1份～3份、抗菌多糖类化合物或衍生物0.5～5份，并使次氯酸的有效浓度在10～500 ppm，且消毒液整体溶液pH保持5.0～7.5，从而使次氯酸伤口消毒液杀菌作用好而且持续时间长。本发明杀菌作用强且杀菌持续时间长，为使消毒液降低对伤口刺激，使HClO有效浓度在10～500 ppm，消毒液整体溶液pH保持5.0～7.5。A hypochlorous acid wound disinfectant containing antibacterial polysaccharide compounds or derivatives belongs to the technical field of disinfectants. It includes 1 to 5 parts by mass of hypochlorous acid (HClO), and is characterized in that it also includes 1 to 3 parts of sodium hypochlorite solution or 1 to 2 parts of calcium hypochlorite or 1 to 1 part of potassium hypochlorite. 2 parts or 1 to 3 parts of barium hypochlorite, 0.5 to 5 parts of antibacterial polysaccharide compounds or derivatives, and the effective concentration of hypochlorous acid is 10 to 500 ppm, and the pH of the overall solution of the disinfectant is kept at 5.0 to 7.5 , so that the hypochlorous acid wound disinfectant has a good bactericidal effect and a long duration. The invention has strong bactericidal effect and long bactericidal duration. In order to reduce the irritation of the disinfectant to the wound, the effective concentration of HClO is kept at 10-500 ppm, and the pH of the whole disinfectant solution is kept at 5.0-7.5.
Description
Technical Field
The invention belongs to the technical field of disinfectant, and particularly relates to hypochlorous acid wound disinfectant containing antibacterial polysaccharide compounds or derivatives.
Background
In recent ten years, hypochlorous acid disinfectant water has been gradually applied to the fields of agriculture, food, environmental protection and the like. Compare in traditional sodium hypochlorite antiseptic solution, the hypochlorous acid antiseptic solution has a great deal of advantage: safe, no side effect, low effective antibacterial concentration, high sterilization speed and the like. Among them, slightly acidic electrolyzed water containing hypochlorous acid has been approved as an edible food additive by the FDA in the united states. There are many documents on hypochlorous acid disinfectant water, and a few patent technical solutions, such as publication numbers: CN 1680627 "preparation method of hypochlorous acid disinfectant fluid", publication no: CN 101686689 "disinfectant based on hypochlorous acid (HOCI) containing aqueous solution, preparation method and application thereof", etc.
Many documents show that hypochlorous acid (chemical formula HClO) or sodium hypochlorite disinfection mechanism plays a key role is HClO. Further decomposition of HClO to form nascent oxygen [ O ] which has strong oxidizing property and can rapidly kill bacteria and viruses. Sodium hypochlorite needs to be further hydrolyzed to hypochlorous acid, and hypochlorous acid is thus more rapidly sterilized than sodium hypochlorite. However, hypochlorous acid is a weak acid, is chemically unstable, and its bactericidal performance is easily affected by light, air, time, contact with impurities, etc., and is likely to undergo electrolysis and decomposition reactions, and thus the bactericidal effect is difficult to last.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a hypochlorous acid wound disinfectant containing antibacterial polysaccharide compounds or derivatives, which has strong sterilization effect and long sterilization duration. In order to reduce the stimulation of the disinfectant to the wound, the effective concentration of hypochlorous acid is 10-500ppm, and the pH value of the whole disinfectant solution is kept at 5.0-7.5.
The invention aims to realize the following technical scheme that the hypochlorous acid wound disinfectant containing the antibacterial polysaccharide compound or the derivative comprises 1 to 5 parts by mass of hypochlorous acid (HClO), and is characterized in that: the disinfectant also comprises 1 to 3 parts of sodium hypochlorite solution, 1 to 2 parts of calcium hypochlorite, 1 to 2 parts of potassium hypochlorite or 1 to 3 parts of barium hypochlorite by mass, and 0.5 to 5 parts of antibacterial polysaccharide compound or derivative, wherein the effective concentration of the hypochlorous acid is 10 to 500ppm, and the pH of the whole solution is kept between 5.0 and 7.5, so that the wound disinfectant of the hypochlorous acid has good sterilization effect and long duration.
Preferably, the antibacterial polysaccharide compound or derivative is one or more of cellulose, starch or chitosan.
Preferably, the antibacterial polysaccharide compound or derivative is a blend of sodium acetate chitosan and cellulose, and the mass portion of the sodium acetate chitosan and the cellulose is 2.5-3.5: 1; the buffer solution also comprises 10 to 30 parts by weight of disodium hydrogen phosphate-sodium dihydrogen phosphate buffer solution, and the pH value of the buffer solution is 5 to 6.5.
Preferably, the antibacterial polysaccharide compound or the derivative thereof comprises 1 to 2 parts by weight of calcium hypochlorite, and the antibacterial polysaccharide compound or the derivative thereof is chitosan; the buffer solution also comprises 10 to 30 parts by weight of disodium hydrogen phosphate-sodium dihydrogen phosphate.
Preferably, the antibacterial polysaccharide compound or the derivative thereof comprises 1 to 5 parts by weight of sodium hypochlorite, and the antibacterial polysaccharide compound or the derivative thereof is hydroxypropyl cellulose; the buffer solution also comprises 5 to 10 parts by weight of buffer solution acetic acid-sodium acetate.
Preferably, the antibacterial polysaccharide compound or the derivative is hydroxyethyl starch, and the antibacterial polysaccharide compound or the derivative is potassium hypochlorite in 1 to 2 parts by weight; the buffer solution potassium hydrogen tartrate solution also comprises 5 to 10 parts by weight of buffer solution potassium hydrogen tartrate.
Preferably, the antibacterial polysaccharide compound or the derivative thereof comprises 1 to 5 parts by weight of sodium hypochlorite, and the antibacterial polysaccharide compound or the derivative thereof is chitosan; the buffer solution also comprises 10 to 30 parts by weight of disodium hydrogen phosphate-sodium dihydrogen phosphate.
Preferably, the antibacterial polysaccharide compound or the derivative thereof comprises 1 to 2 parts by mass of calcium hypochlorite, and the antibacterial polysaccharide compound or the derivative thereof is sodium carboxymethyl cellulose; the buffer solution boric acid solution also comprises 5 to 10 parts by weight of buffer solution boric acid.
Preferably, the antibacterial polysaccharide compound also comprises 1 to 2 parts by mass of barium hypochlorite, wherein the antibacterial polysaccharide compound or derivative is carboxymethyl chitosan; the buffer solution also comprises 10 to 30 parts by weight of disodium hydrogen phosphate-sodium dihydrogen phosphate.
Preferably, the polysaccharide compound or derivative added into the solution has a particle size of nanometer or micrometer.
The invention has the beneficial effects that: because the disinfectant is added with polysaccharide substances and derivatives, the substances have antibacterial effect, good biocompatibility and excellent film-forming property, when the disinfectant is used as a medical disinfectant and is sprayed on the surface of skin or a wound to form an antibacterial and bacteriostatic breathable layer on the surface of the skin or the wound, the breathable layer has obvious antibacterial and bacteriostatic effects on pathogenic microorganisms, can keep the antibacterial property for a long time and is beneficial to wound healing; in addition, the disinfectant can reduce the stimulation to the wound. The disinfectant is sprayed on the surface of an object, hypochlorous acid is firstly used for quickly sterilizing, and after the liquid volatilizes, the polysaccharide substance and the derivative antibacterial substance can form an antibacterial protective layer on the surface of the object, so that the surface of the object has continuous antibacterial or bacteriostatic ability.
Detailed Description
The invention is further described below by means of 8 examples:
example 1
A hypochlorous acid wound disinfectant containing antibacterial polysaccharide compounds or derivatives comprises 1 part hypochlorous acid with the concentration of 50ppm by mass and 3 parts sodium hypochlorite with the concentration of 10 ppm by mass, and comprises the antibacterial polysaccharide compounds or derivatives, wherein the antibacterial polysaccharide compounds or derivatives are a blend of 5 parts sodium acetate chitosan and cellulose with the nanometer particle size of 1000 mu m by mass, 5 parts sodium acetate chitosan by mass and 5 parts cellulose by mass; the buffer solution also comprises 10 parts by mass of disodium hydrogen phosphate-sodium dihydrogen phosphate with the solution concentration of 100ppm, and the pH value of the disodium hydrogen phosphate-sodium dihydrogen phosphate is 5.8; the pH value of the whole disinfectant solution is 6. The disinfectant needs to be protected from light and stored in a sealed way.
Example 2
The hypochlorous acid wound disinfectant containing antibacterial polysaccharide compounds or derivatives comprises 1 part by mass of hypochlorous acid 3 with the concentration of 30 ppm and 1 part by mass of calcium hypochlorite 7 with the concentration of 7 ppm, wherein the antibacterial polysaccharide compounds or derivatives are 5 parts by mass of chitosan with the nano-particle size of 100 nm, the antibacterial polysaccharide compounds or derivatives further comprise 10 parts by mass of buffer solution disodium hydrogen phosphate-sodium dihydrogen phosphate with the concentration of 100ppm, and the pH value of the whole disinfectant solution is 6.5. The disinfectant needs to be protected from light and stored in a sealed way.
Embodiment 3
A hypochlorous acid wound disinfectant containing antibacterial polysaccharide compounds or derivatives comprises 3 parts of hypochlorous acid with the solution concentration of 80ppm by mass and 5 parts of sodium hypochlorite with the solution concentration of 20 ppm by mass, wherein the antibacterial polysaccharide compounds or derivatives are 2 parts of hydroxypropyl cellulose with the nano-particle size of 30 nm by mass, the antibacterial polysaccharide compounds or derivatives further comprise 5 parts of buffer acetic acid-sodium acetate with the solution concentration of 80ppm by mass, and the pH value of the whole disinfectant solution is 6.5. The disinfectant needs to be protected from light and stored in a sealed way.
Example 4
A hypochlorous acid wound disinfectant containing antibacterial polysaccharide compounds or derivatives comprises 5 parts by weight of hypochlorous acid with the concentration of 30 ppm and 2 parts by weight of potassium hypochlorite with the concentration of 20 ppm, wherein the antibacterial polysaccharide compounds or derivatives are 2 parts by weight of hydroxyethyl starch with the nanometer particle size of 60 nm, 10 parts by weight of buffer solution potassium hydrogen tartrate with the concentration of 100ppm, and the pH value of the whole disinfectant solution is 6.3. The disinfectant needs to be protected from light and stored in a sealed way.
Example 5
A hypochlorous acid wound disinfectant containing antibacterial polysaccharide compounds or derivatives comprises 3 parts by weight of hypochlorous acid with the solution concentration of 100ppm and 5 parts by weight of sodium hypochlorite with the solution concentration of 10 ppm, wherein the antibacterial polysaccharide compounds or derivatives are 5 parts by weight of chitosan with the nano-particle size of 80 nm, 15 parts by weight of buffer solution disodium hydrogen phosphate-sodium dihydrogen phosphate with the solution concentration of 200ppm, and the pH value of the whole disinfectant solution is 5.2. The disinfectant needs to be protected from light and stored in a sealed way.
Example 6
The hypochlorous acid wound disinfectant containing antibacterial polysaccharide compounds or derivatives comprises 5 parts by weight of hypochlorous acid with the solution concentration of 200ppm and 2 parts by weight of calcium hypochlorite with the solution concentration of 81 ppm, wherein the antibacterial polysaccharide compounds or derivatives are 2 parts by weight of sodium carboxymethylcellulose with the nano-particle size of 300 nm, the antibacterial polysaccharide compounds or derivatives also comprise 5 parts by weight of buffer boric acid with the solution concentration of 50ppm, and the pH value of the whole disinfectant solution is 5.0. The disinfectant needs to be protected from light and stored in a sealed way.
Example 7
The wound disinfectant containing antibacterial polysaccharide compounds or derivatives comprises 2 parts by mass of hypochlorous acid with the concentration of 100ppm and 8 ppm of barium hypochlorite with the concentration of 8 ppm and 1 part by mass of barium hypochlorite with the concentration of 8 ppm, wherein the antibacterial polysaccharide compounds or derivatives are 2 parts by mass of carboxymethyl chitosan with the nano-particle size of 150 nm, the antibacterial polysaccharide compounds or derivatives further comprise 20 parts by mass of buffer solution disodium hydrogen phosphate-sodium dihydrogen phosphate with the concentration of 50ppm, and the pH value of the whole disinfectant solution is 5.6. The disinfectant needs to be protected from light and stored in a sealed way.
Example 8
The hypochlorous acid wound disinfectant containing antibacterial polysaccharide compounds or derivatives comprises 5 parts by weight of hypochlorous acid with the solution concentration of 60 ppm and 5 parts by weight of hypochlorous acid with the solution concentration of 4ppm, wherein the antibacterial polysaccharide compounds or derivatives comprise 10 parts by weight of chitosan with the micron particle size of 2 microns, 10 parts by weight of buffer solution potassium hydrogen tartrate with the solution concentration of 80ppm, and the pH value of the whole disinfectant solution is 6.5. The disinfectant needs to be protected from light and stored in a sealed way.
Claims (9)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711204955.9A CN108079017B (en) | 2017-11-27 | 2017-11-27 | Hypochlorous acid wound disinfectant containing antibacterial polysaccharide compounds or derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711204955.9A CN108079017B (en) | 2017-11-27 | 2017-11-27 | Hypochlorous acid wound disinfectant containing antibacterial polysaccharide compounds or derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108079017A CN108079017A (en) | 2018-05-29 |
| CN108079017B true CN108079017B (en) | 2020-04-07 |
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| CN201711204955.9A Active CN108079017B (en) | 2017-11-27 | 2017-11-27 | Hypochlorous acid wound disinfectant containing antibacterial polysaccharide compounds or derivatives |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109200326A (en) * | 2018-07-19 | 2019-01-15 | 丁力行 | Dressing and adhesive bandage for wound healing |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1533695A (en) * | 2003-03-28 | 2004-10-06 | 南京万福金安生物技术有限公司 | Sterilizing solution and its preparation method and use |
| CN101686689A (en) * | 2007-05-15 | 2010-03-31 | 埃克蒂德斯有限责任公司 | Disinfectant based on aqueous, hypochlorous acid (hoci)-containing solutions, method for the production thereof, and use thereof |
-
2017
- 2017-11-27 CN CN201711204955.9A patent/CN108079017B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1533695A (en) * | 2003-03-28 | 2004-10-06 | 南京万福金安生物技术有限公司 | Sterilizing solution and its preparation method and use |
| CN101686689A (en) * | 2007-05-15 | 2010-03-31 | 埃克蒂德斯有限责任公司 | Disinfectant based on aqueous, hypochlorous acid (hoci)-containing solutions, method for the production thereof, and use thereof |
Non-Patent Citations (2)
| Title |
|---|
| 不同消毒液对手外科感染伤口消毒的效果比较;周海微等;《解放军护理杂志》;20170630;第34卷(第12期);第70-71页 * |
| 碘制剂和壳聚糖制剂对烧伤创面局部抗感染作用的研究;李亚林等;《中华临床医师杂志(电子版)》;20130228;第7卷(第4期);第1739页 * |
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