CN108042755A - It is a kind of to be used to treat weakness of the spleen and the stomach oral traditional Chinese medicine composition and its application - Google Patents

Abstract

The invention discloses a kind of raw material components treated weakness of the spleen and the stomach oral traditional Chinese medicine composition, include following parts by weight：9~21 parts of radix pseudostellariae, 6~14 parts of Rhizoma Atractylodis Macrocephalae, 15~35 parts of Poria cocos, Charred Triplet are 18~42 parts each, 9~21 parts of the membrane of a chicken's gizzard, 6~14 parts of Radix Aucklandiae, 6~14 parts of fructus amomi, 3~7 parts of Radix Glycyrrhizae.It is evident in efficacy and without any side effects provided by the present invention for treating weakness of the spleen and the stomach oral traditional Chinese medicine composition, it can be used for treating weakness of the spleen and the stomach, there is good therapeutic effect.

Description

A kind of oral Chinese medicinal composition for treating weak spleen and stomach and its application

technical field

The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to an oral Chinese medicinal composition for treating weakness of the spleen and stomach and an application thereof.

Background technique

Weakness of the spleen and stomach is a term in traditional Chinese medicine. Deficiency of the spleen and stomach has a relatively general meaning, including TCM syndromes such as deficiency of the spleen, deficiency of spleen yang, failure of the spleen to control the blood, depression of middle qi, deficiency of stomach yang, deficiency of stomach qi, deficiency of stomach yin, and deficiency of spleen and stomach. Among them, deficiency of the spleen is the basic type of weakness of the spleen and stomach, and syndrome of deficiency of the spleen refers to the syndrome manifested by deficiency of the spleen and loss of its healthy movement. Mostly due to intemperance in diet, overwork, prolonged illness and injury of temper. Common clinical manifestations of weak spleen and stomach: long course of disease, diarrhea that can be mild or severe, or intermittent, loose and loose stools, light in color and odorless, with undigested food residues, easy diarrhea after eating, and see after eating too much Abdominal distension, frequent stools, loss of appetite, sallow complexion, fatigue, emaciated body, pale tongue, thin white fur, weak pulse.

It is one of the effective means to comprehensively treat spleen and stomach weakness with traditional Chinese medicine compound. The development and invention of oral Chinese medicine compound for the treatment of spleen and stomach weakness is of great significance to human beings and society.

Contents of the invention

The technical problem to be solved by the present invention is to provide a traditional Chinese medicine composition which has significant curative effect on weak spleen and stomach and has no side effects and its application.

The first object of the present invention is to provide an oral Chinese medicine composition for treating weakness of the spleen and stomach, comprising the following raw material components in parts by weight: 9-21 parts of Radix Pseudostellariae, 6-14 parts of Atractylodes Rhizome, 15-35 parts of Poria cocos , 18-42 parts of Jiao Sanxian, 9-21 parts of Chicken Neijin, 6-14 parts of Muxiang, 6-14 parts of Amomum, and 3-7 parts of Licorice.

Preferably, the present invention provides an oral Chinese medicine composition for treating weakness of the spleen and stomach, including the following raw material components in parts by weight: 15 parts of Radix Pseudostellariae, 10 parts of Atractylodes Rhizoma Atractylodes Rhizome, 25 parts of Poria cocos, 30 parts of Jiaosanxian, Gallus gallis 15 parts, woody 10 parts, amomum 10 parts, licorice 5 parts.

Preferably, the Jiaosanxian is Jiaomaiya, Jiaohazha and Jiaoshenqu.

The second object of the present invention is to provide the application of the above-mentioned oral Chinese medicine composition for treating weakness of the spleen and stomach in the preparation of pharmaceutical preparations for weakness of the spleen and stomach.

Preferably, the pharmaceutical dosage form of the pharmaceutical preparation is tablet, capsule, granule, dispersible tablet or pill.

The fourth object of the present invention is to provide the application of the above-mentioned oral Chinese medicine composition for treating weakness of the spleen and stomach in the preparation of food, cosmetics, washing products or toothpaste.

The pharmacological action of each component in the composition of the present invention:

Pseudostellaria Pseudostellariae is a monarch drug, sweet in taste, slightly bitter, and flat in nature; it enters the three meridians of the heart, spleen, and lung. Can invigorate qi and spleen, nourish yin and promote fluid. Atractylodes macrocephala is a ministerial drug, which invigorates the spleen, dries dampness, and aids in transportation and transformation, and Pseudostellariae Radix Pseudostellariae, to enhance the effect of Pseudostellariae Radix Pseudostellariae on invigorating Qi and invigorating the spleen. The adjuvant medicine is Poria for removing dampness and invigorating the spleen, combined with Lingzhu to promote the strengthening of spleen and dehumidification and the power of transportation and transformation; Jiao Sanxian, that is, Jiao Maiya, Jiao Hawthorn, and Jiao Shenqu. These three medicines all have a good function of eliminating stagnation and stagnation, but they have different characteristics. Burnt malt has a good effect on digesting starchy foods; Jiaoshanzha is good at treating food stagnation caused by too much meat or greasy food; Jiao Shenqu is good for digesting rice and noodles; the combination of the three medicines can significantly enhance digestion. The chicken is golden sweet, cold. Return spleen, stomach, small intestine, bladder meridian, promote digestion, invigorate the stomach and help digestion, astringent essence to stop nocturnal emission. It can promote the secretion of gastric juice, increase gastric acidity and digestion, significantly enhance gastric motility, and accelerate gastric emptying. The medicine is woody fragrance pungent, bitter, warm in nature; it returns to the spleen, stomach, liver, and large intestine meridian, and the fragrance is dispersed, which can rise and fall; promote qi and relieve pain, regulate qi and soothe the liver, strengthen the spleen and eliminate stagnation. Amomum is pungent in taste and warm in nature; it belongs to the spleen, stomach, and kidney meridians; it removes dampness and appetizers, warms the spleen and relieves diarrhea, regulates qi and relieves miscarriage. Licorice, sweet and warm, can regulate various medicines and make them work together to invigorate Qi and strengthen the spleen. All medicines are used in combination to invigorate qi and invigorate the spleen, promote digestion and guide stagnation; it is used for abdominal distension and loss of appetite due to deficiency of spleen and stomach qi, poor appetite, lack of appetite, loose stools, shortness of breath and fatigue.

Compared with prior art, the beneficial effect of the present invention is:

The oral Chinese medicine composition for treating weakness of the spleen and stomach provided by the present invention has significant curative effect and no side effects, and can not only be used for the preparation of medicines for treating weakness of the spleen and stomach, but also can be processed into food as a dietotherapy medicine or applied to cosmetics, washing products and toothpaste in the preparation process.

Detailed ways

In order to enable those skilled in the art to better understand that the technical solutions of the present invention can be implemented, the present invention will be further described below in conjunction with specific examples, but the given examples are not intended to limit the present invention.

The test methods that do not indicate specific conditions in the following examples are all carried out according to conventional methods and conditions in this area, and the raw materials used are all commercially available.

Example 1

In this embodiment, an oral Chinese medicine composition for treating weakness of the spleen and stomach includes the following raw material components in parts by weight: 15 parts of Radix Pseudostellariae, 10 parts of Atractylodes Rhizoma Atractylodes Rhizome, 25 parts of Poria cocos, 30 parts of Jiao Sanxian each, 15 parts of Gallus gallis, 10 parts of woody fragrance, 10 parts of amomum, 5 parts of licorice.

The preparation process of the above-mentioned traditional Chinese medicine composition is very simple. After weighing each raw material component in proportion, they are respectively pulverized, and the pulverized raw materials are mixed evenly, and prepared into tablets according to the conventional production process of pharmaceutical preparations.

Example 2

In this embodiment, an oral Chinese medicine composition for treating weakness of the spleen and stomach includes the following raw material components in parts by weight: 9 parts of Radix Pseudostellariae, 8 parts of Atractylodes Rhizoma Atractylodes Rhizome, 15 parts of Poria cocos, 20 parts of Jiao Sanxian each, 9 parts of Gallus gallis, 6 parts of woody fragrance, 6 parts of amomum, 4 parts of licorice.

After the above-mentioned raw material components are weighed in proportion, they are respectively pulverized, and the pulverized raw materials are mixed evenly, and prepared into capsules according to the conventional production process of pharmaceutical preparations.

Example 3

In this embodiment, an oral Chinese medicine composition for treating weakness of the spleen and stomach comprises the following raw material components in parts by weight: 21 parts of Radix Pseudostellariae, 14 parts of Atractylodes Rhizoma Atractylodes Rhizome, 30 parts of Poria cocos, 42 parts of Jiao Sanxian each, 18 parts of Gallus gallis, 14 parts of woody fragrance, 14 parts of amomum, 7 parts of licorice.

After the above-mentioned raw material components are weighed in proportion, they are pulverized respectively, and the pulverized raw materials are mixed evenly, and are prepared into granules according to the conventional production process of pharmaceutical preparations.

Example 4

In this embodiment, an oral Chinese medicine composition for treating weakness of the spleen and stomach comprises the following raw material components in parts by weight: 18 parts of Radix Pseudostellariae, 10 parts of Atractylodes Rhizoma Atractylodes Rhizome, 35 parts of Poria cocos, 25 parts of Jiaosanxian each, 21 parts of Gallus gallis, 12 parts of woody fragrance, 12 parts of amomum, 3 parts of licorice.

After the above-mentioned raw material components are weighed in proportion, they are pulverized respectively, and the pulverized raw materials are mixed evenly, and prepared into pills according to the conventional production process of pharmaceutical preparations.

Examples 1 to 4 have all prepared preparations for treating weakness of the spleen and stomach with good effects. Since the effects of the preparations prepared in Examples 1 to 4 for treating weakness of the spleen and stomach are basically parallel, only the traditional Chinese medicine prepared in Example 1 is used. Preparations are used to illustrate the effects of the present invention.

The effects of the present invention will be further described by adopting animal experiments and clinical trials below.

1. Animal experiments

1. Acute toxicity test

60 NIH mice, SPF grade, half male and half male, weighing 18-22g, were used for acute toxicity test. Mice are divided into two groups at random, every group of 30, i.e. control group and administration group, fasting 12 hours before experiment; The tablet that the embodiment of the present invention 1 is prepared to treat weak spleen and stomach is dissolved in water, (concentration is 6g Crude drug/mL, the highest concentration) by gavage, the volume of gavage is 5mL/kg (that is, the single dose is 30g crude drug/kg), the control group is given the same amount of normal saline, administered twice a day, with an interval of 6 Hours, continuous observation for 14 days after administration, and record the number of toxic reactions and deaths of the mice.

The results of the experiment showed that compared with the control group, there was no significant difference in the mice after administration. After 14 days of continuous observation in the experiment, the general condition, diet, drinking water, and weight gain of the mice were all normal. Mice are orally gavaged. The tablet LD50 of the present invention for treating weakness of the spleen and stomach is greater than 30g crude drug/kg, and the maximum daily dosage is 60g crude drug/kg/day. The clinical dosage of the traditional Chinese medicine preparation prepared in Example 1 of the present invention is 12g crude drug/day/person, and the adult body weight is 60kg, and the average dosage is 0.2g crude drug/kg/day. By body weight: the tolerated dose of the traditional Chinese medicine preparation of the present invention is 300 times that of the clinical dosage in mice (average body weight in 20 g). Therefore, the traditional Chinese medicine preparation of the present invention has low acute toxicity and is safe for clinical use.

2. Long-term toxicity test

The embodiment of the present invention 1 prepares the tablet for the treatment of weakness of the spleen and stomach to mice by 10.02g, 20.35g and 33.48g crude drug/kg continuous medication for 10 weeks (1.0mL/100g body weight, 2 times a day) and after drug withdrawal for 4 weeks to mice Rats were observed and tested.

The experimental results show that: the tablet prepared in Example 1 of the present invention for treating weakness of the spleen and stomach has no significant effect on the hair, behavior, urine and stool, body weight, organ weight, blood picture, liver and kidney function, blood sugar, blood lipids and other indicators of rats. No abnormal changes were found in the viscera with the naked eye, and the results of histological examination showed that after 10 weeks of medication and 4 weeks after drug withdrawal, there was no obvious change in each organ of the rat. It shows that the tablet prepared in Example 1 of the present invention for treating weakness of the spleen and stomach has little toxicity to rats after long-term administration, and there is no abnormal reaction after drug withdrawal, so the application is safe.

2. Clinical trials

1. Clinical cases

Diagnosed patients with weakness of the spleen and stomach were the subjects of the study. 95 clinical cases were selected, including 58 males and 37 females. The oldest was 69 years old and the youngest was 27 years old. Spleen and stomach weakness, other patients cannot participate in this experiment.

2. Treatment method

Take the tablet prepared by the embodiment of the present invention 1 during the treatment period, take it with warm water, take it once every morning and evening, 2 tablets at a time, 3g per tablet, and the treatment cycle is 4 weeks.

3. Evaluation of treatment effect:

Significantly effective: After treatment, the symptoms were significantly reduced compared with those before treatment, and all inspection indicators basically returned to normal.

Effective: After treatment, the symptoms were reduced, and various indicators were improved.

Ineffective: After treatment, the symptoms did not improve significantly.

4. Experimental results

Of the 95 patients, 71 were cured and 24 were markedly effective, with a total effective rate of 100%. After a course of treatment (4 weeks), the symptoms were eliminated and healed.

5. Typical cases

(1) Spleen Qi Deficiency Case: Male, 45 years old, was diagnosed with fullness in the abdomen and abdomen, especially after eating, no taste in the mouth, even no desire to eat, loose stools, lack of energy, emaciated body, tired limbs, lack of energy and laziness to speak, Pale or pale complexion, or swollen limbs, pale tongue with white fur, slow and weak pulse. Taking other therapeutic drugs did not improve, and after taking the tablet prepared by Example 1 of the present invention for treating weakness of the spleen and stomach for 5 days, the above symptoms disappeared.

(2) Spleen Yang Deficiency Cases: Female, 27 years old, with abdominal distension, anorexia, continuous abdominal pain, warm and pressing, cold and cold extremities, loose stools, thin and thin leucorrhea, pale and fat tongue, white and slippery fur, The pulse is slow and weak. After taking the tablet prepared by Example 1 of the present invention for treating weakness of the spleen and stomach for 3 days, the symptoms were relieved, and continued to take for 4 days, and all symptoms disappeared.

(3) Cases of subsidence of Qi: male, 30 years old, pale complexion, dizzy and prone to sweating, shortness of breath, fatigue, lack of appetite, loose stools, heavy abdomen, frequent defecation. After taking the tablet prepared by Example 1 of the present invention for treating weakness of the spleen and stomach for 6 days, the food intake increased, the stool was normal, and the feeling of abdominal distension disappeared.

(4) Case of spleen not controlling blood: Female, 31 years old, lack of food, abdominal distension, loose stools, body fatigue, lack of breath, lazy to speak, sallow complexion, menorrhagia, pale tongue with white coating, slow and weak pulse. All symptoms disappeared after taking the tablet prepared by Example 1 of the present invention for treating weakness of the spleen and stomach for 5 days.

(5) Cases of spleen-yin deficiency: male, 30 years old, dry mouth and lips, noisy, retching, reduced diet, or difficulty swallowing, chest and diaphragm discomfort after eating, dry stool, red tongue with dry center, little coating, thready pulse Wait. After taking the tablet prepared by Example 1 of the present invention for treating weakness of the spleen and stomach for 4 days, all symptoms disappeared.

To sum up, the traditional Chinese medicine of the present invention has reasonable prescriptions, low cost, convenient drug materials, simple preparation, short course of treatment, significant curative effect, high cure rate, and no toxic or side effects.

It should be noted that when a numerical range is involved in the claims of the present invention, it should be understood that the two endpoints of each numerical range and any value between the two endpoints can be selected, because the steps and methods adopted are the same as those in Embodiment 1- 4 Similarly, to avoid repetition, the present invention describes preferred embodiments, but those skilled in the art can make additional changes and modifications to these embodiments once the basic inventive concepts are known. Therefore, it is intended that the appended claims be construed to cover the preferred embodiment as well as all changes and modifications which fall within the scope of the invention.

Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalent technologies, the present invention also intends to include these modifications and variations.

Claims (6)

1. a kind of be used to treat weakness of the spleen and the stomach oral traditional Chinese medicine composition, which is characterized in that includes the raw material of following parts by weight Component：9~21 parts of radix pseudostellariae, 6~14 parts of Rhizoma Atractylodis Macrocephalae, 15~35 parts of Poria cocos, Charred Triplet are 18~42 parts each, 9~21 parts of the membrane of a chicken's gizzard, wood 6~14 parts fragrant, 6~14 parts of fructus amomi, 3~7 parts of Radix Glycyrrhizae.

2. according to claim 1 be used to treat weakness of the spleen and the stomach oral traditional Chinese medicine composition, which is characterized in that including following The raw material components of parts by weight：15 parts of radix pseudostellariae, 10 parts of Rhizoma Atractylodis Macrocephalae, 25 parts of Poria cocos, Charred Triplet are 30 parts each, 15 parts of the membrane of a chicken's gizzard, Radix Aucklandiae 10 parts, 10 parts of fructus amomi, 5 parts of Radix Glycyrrhizae.

3. according to claim 1 or 2 be used to treat weakness of the spleen and the stomach oral traditional Chinese medicine composition, which is characterized in that described Charred Triplet is melanoidin malt, charred FRUCTUS CRATAEGI and stir-baked MASSA FERMENTATA MEDICI-NALIS.

4. according to claim 1 or 2 preparing weakness of the spleen and the stomach medicine for treating weakness of the spleen and the stomach oral traditional Chinese medicine composition Application in object preparation.

5. application according to claim 4, which is characterized in that the pharmaceutical dosage form of the pharmaceutical preparation for tablet, capsule, Granule, Disket or pill.

6. according to claim 1 or 2 preparing food, makeup for treating weakness of the spleen and the stomach oral traditional Chinese medicine composition Application in product, articles for washing or toothpaste.