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CN107802710A - A kind of medicine for treating hepatitis B and preparation method thereof - Google Patents

A kind of medicine for treating hepatitis B and preparation method thereof Download PDF

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Publication number
CN107802710A
CN107802710A CN201711079746.6A CN201711079746A CN107802710A CN 107802710 A CN107802710 A CN 107802710A CN 201711079746 A CN201711079746 A CN 201711079746A CN 107802710 A CN107802710 A CN 107802710A
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medicine
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廖会吉
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/46Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486Millettia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/51Gentianaceae (Gentian family)
    • A61K36/515Gentiana
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/536Prunella or Brunella (selfheal)
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The invention discloses a kind of medicine for treating hepatitis B and preparation method thereof, the medicine of the treatment hepatitis B, by weight, including following raw material:10 14 parts of mountain lima bean, 10 14 parts of manynerve bauhinia leaf, 10 14 parts of felwort, 10 14 parts of golden cypress, 8 12 parts of dandelion, 8 12 parts of hypericum japonicum, 8 12 parts of the Radix Astragali, bitter golden 8 12 parts of basin, 8 12 parts of the bark of eucommia, 8 12 parts of chrysanthemum indicum rattan, 6 10 parts of selfheal, 6 10 parts of kuh-seng, 6 10 parts of reticulate millettia, 6 10 parts of bridle grass, 46 parts of rheum officinale, 46 parts of calamus, 8 12 parts of Chinese mahonia.Its preparation method is added other bulk drugs in addition to rheum officinale in 68 times of water of medicinal material total amount, is cooked by slow fire 8 12 minutes, is taken filtrate;8 10 times of water of medicinal material total amount is added, is cooked by slow fire 18 22 minutes, takes filtrate;Add 8 10 times of water of medicinal material total amount, be cooked by slow fire 28 32 minutes, after rheum officinale under, take filtrate;It is well mixed to produce after inciting somebody to action filtrate merging three times.The characteristics of with rapid-action, good effect, safe without toxic side effect.Clinical 1200 patients use, total effective rate 90%.

Description

A kind of medicine for treating hepatitis B and preparation method thereof
Technical field
The invention belongs to the field of Chinese medicines, and in particular to a kind of medicine for treating hepatitis B, also relate to the treatment hepatitis B The preparation method of medicine.
Background technology
Chronic hepatitis B(Abbreviation hepatitis B)Refer to hepatitis B test positive, the course of disease exceedes half a year or date of the onset not Clearly and clinic has chronic hepatitis shower.Clinical manifestation is the symptoms such as weak, sitophobia, nausea, abdominal distension, hepatalgia.Hepatomegaly, Quality is medium hardness, there is light tenderness.State of an illness severe one can with chronic liver disease face, spider angioma, liver palms, splenomegaly, liver function Exception or persistent anomaly.Slight, moderate and severe are divided into according to clinical manifestation.And chronic hepatitis B carries and refers to that hepatitis B detects For the positive, no chronic hepatitis symptom, continuous more than 3 times Serum ALTs of follow-up and AST are without exception in 1 year, and liver histological inspection Normal person.Chronic hepatitis B is due to hepatitis b virus infection(HBV)It is caused, hepatitis B patient and HBV carrier It is this sick major source of infection, HBV can pass through mother and baby, blood and blood product, the skin and mucosa of breakage and transmission through sex.
At present, the existing viral medicine such as interferon for the treatment of is to kill virus indirectly while antibody is increased, and is turned Cloudy rate is low, and easily recurrence.Treatment by Chinese herbs adverse reaction is small, and also species is various for used Chinese medicine in the market, but effect Uneven, I is unequal to ideal, and most Chinese medicinal ingredients are more, long-term use of liver kidney heavy load, is not suitable for long-term use.
The content of the invention
It is an object of the invention to provide the medicine of a kind of rapid-action, good effect, the treatment hepatitis B of Small side effects.
Another object of the present invention is to the preparation method for the medicine for providing the treatment hepatitis B.
A kind of medicine for treating hepatitis B of the present invention, by weight, including following raw material:
Mountain lima bean 10-14 parts, manynerve bauhinia leaf 10-14 parts, felwort 10-14 parts, golden cypress 10-14 parts, dandelion 8-12 parts, Tian Ji Yellow 8-12 parts, Radix Astragali 8-12 parts, bitter golden basin 8-12 parts, bark of eucommia 8-12 parts, chrysanthemum indicum rattan 8-12 parts, selfheal 6-10 parts, kuh-seng 6-10 parts, reticulate millettia 6-10 parts, bridle grass 6-10 parts, rheum officinale 4-6 parts, calamus 4-6 parts, Chinese mahonia 8-12 parts.
A kind of above-mentioned medicine for treating hepatitis B, by weight, preferably following raw material:
12 parts of mountain lima bean, 12 parts of manynerve bauhinia leaf, 12 parts of felwort, 12 parts of golden cypress, 10 parts of dandelion, 10 parts of hypericum japonicum, the Radix Astragali 10 Part, bitter golden 10 parts of basin, 10 parts of the bark of eucommia, 10 parts of chrysanthemum indicum rattan, 8 parts of selfheal, 8 parts of kuh-seng, 8 parts of reticulate millettia, bridle are careless 8 parts, big Yellow 5 parts, 5 parts of calamus, 10 parts of Chinese mahonia.
A kind of above-mentioned medicine for treating hepatitis B, its preparation method comprise the following steps:
(1)Each bulk drug is taken by weight;
(2)Other bulk drugs in addition to rheum officinale are added in 6-8 times of water of medicinal material total amount, be cooked by slow fire 8-12 minutes, take Filtrate;8-10 times of water of medicinal material total amount is added, 18-22 minutes is cooked by slow fire, takes filtrate;Add the 8-10 of medicinal material total amount Times water, be cooked by slow fire 28-32 minutes, after rheum officinale under, take filtrate;It is well mixed to produce after inciting somebody to action filtrate merging three times.
The present invention compared with prior art, has obvious beneficial effect, as can be known from the above technical solutions:The present invention selects mountain Lima bean, manynerve bauhinia leaf, felwort, golden cypress, dandelion, hypericum japonicum, the Radix Astragali, bitter golden basin, the bark of eucommia, chrysanthemum indicum rattan, selfheal, hardship Ginseng, reticulate millettia, bridle grass, rheum officinale, calamus, Chinese mahonia are raw material, and clearing heat and detoxicating, taste is played by the synergy between medicine The effect of filling liver kidney, soothing the liver protect liver.Reach the purpose for the treatment of hepatitis B.The drug therapy hepatitis B of the present invention has rapid-action, curative effect Well, the characteristics of safe without toxic side effect.Clinical 1200 patients use, total effective rate 90%.
Embodiment
The beneficial effect of medicine of the present invention is expanded on further below by way of test example.
Test example:The clinical observation of medicine of the present invention
1st, clinical data:
All cases 1200, age 7-68 year, man 610, female 590.
2nd, diagnostic criteria:
《Disease of tcm Standardization of diagnosis and curative effect》.
3rd, treatment method:
Oral present invention gained medicine, three times a day, drink the cuvette of sanitary cup one after heating every time.
4th, criterion of therapeutical effect:
It is effective:Symptom disappears;
Effectively:Symptom is relieved;
It is invalid:Symptom is not improved.
5th, treatment results:
1200 patients use medicine of the present invention, effective 840, effective 240, invalid 120, obvious effective rate 70%, total effective rate 90%。
Embodiment 1
A kind of preparation method for the medicine for treating hepatitis B, comprises the following steps:
(1)Weigh mountain lima bean 10g, manynerve bauhinia leaf 14g, felwort 10g, golden cypress 14g, dandelion 8g, hypericum japonicum 12g, Radix Astragali 8g, Bitter golden basin 12g, bark of eucommia 8g, chrysanthemum indicum rattan 12g, selfheal 6g, kuh-seng 10g, reticulate millettia 6g, bridle grass 10g, rheum officinale 4g, calamus 6g, Chinese mahonia 8g;
(2)Other bulk drugs in addition to rheum officinale are added in 6 times of water of medicinal material total amount, be cooked by slow fire 12 minutes, take filtrate; 8 times of water of medicinal material total amount is added, is cooked by slow fire 22 minutes, takes filtrate;8 times of water of medicinal material total amount is added, is cooked by slow fire Boil 32 minutes, after rheum officinale under, take filtrate;It is well mixed to produce after inciting somebody to action filtrate merging three times.
Embodiment 2
A kind of preparation method for the medicine for treating hepatitis B, comprises the following steps:
(1)Weigh mountain lima bean 12g, manynerve bauhinia leaf 12g, felwort 12g, golden cypress 12g, dandelion 10g, hypericum japonicum 10g, the Radix Astragali 10g, bitter golden basin 10g, bark of eucommia 10g, chrysanthemum indicum rattan 10g, selfheal 8g, kuh-seng 8g, reticulate millettia 8g, bridle grass 8g, rheum officinale 5g, Chang Pu 5g, Chinese mahonia 10g;
(2)Other bulk drugs in addition to rheum officinale are added in 7 times of water of medicinal material total amount, be cooked by slow fire 10 minutes, take filtrate; 9 times of water of medicinal material total amount is added, is cooked by slow fire 20 minutes, takes filtrate;9 times of water of medicinal material total amount is added, is cooked by slow fire Boil 30 minutes, after rheum officinale under, take filtrate;It is well mixed to produce after inciting somebody to action filtrate merging three times.
Embodiment 3
A kind of preparation method for the medicine for treating hepatitis B, comprises the following steps:
(1)Weigh mountain lima bean 14g, manynerve bauhinia leaf 10g, felwort 14g, golden cypress 10g, dandelion 12g, hypericum japonicum 8g, the Radix Astragali 12g, bitter golden basin 8g, bark of eucommia 12g, chrysanthemum indicum rattan 8g, selfheal 10g, kuh-seng 6g, reticulate millettia 10g, bridle grass 6g, rheum officinale 6g, Chang Pu 4g, Chinese mahonia 12g;
(2)Other bulk drugs in addition to rheum officinale are added in 8 times of water of medicinal material total amount, be cooked by slow fire 8 minutes, take filtrate; 10 times of water of medicinal material total amount is added, is cooked by slow fire 18 minutes, takes filtrate;Add 10 times of water of medicinal material total amount, slow fire Decoct 28 minutes, after rheum officinale under, take filtrate;It is well mixed to produce after inciting somebody to action filtrate merging three times.
The above described is only a preferred embodiment of the present invention, not making any formal limitation to the present invention, appoint Without departing from technical solution of the present invention content, what the technical spirit according to the present invention was made to above example any simply repaiies for what Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.

Claims (3)

1. a kind of medicine for treating hepatitis B, by weight, including following raw material:
Mountain lima bean 10-14 parts, manynerve bauhinia leaf 10-14 parts, felwort 10-14 parts, golden cypress 10-14 parts, dandelion 8-12 parts, Tian Ji Yellow 8-12 parts, Radix Astragali 8-12 parts, bitter golden basin 8-12 parts, bark of eucommia 8-12 parts, chrysanthemum indicum rattan 8-12 parts, selfheal 6-10 parts, kuh-seng 6-10 parts, reticulate millettia 6-10 parts, bridle grass 6-10 parts, rheum officinale 4-6 parts, calamus 4-6 parts, Chinese mahonia 8-12 parts.
2. a kind of medicine for treating hepatitis B as claimed in claim 1, by weight, including following raw material:
12 parts of mountain lima bean, 12 parts of manynerve bauhinia leaf, 12 parts of felwort, 12 parts of golden cypress, 10 parts of dandelion, 10 parts of hypericum japonicum, the Radix Astragali 10 Part, bitter golden 10 parts of basin, 10 parts of the bark of eucommia, 10 parts of chrysanthemum indicum rattan, 8 parts of selfheal, 8 parts of kuh-seng, 8 parts of reticulate millettia, bridle are careless 8 parts, big Yellow 5 parts, 5 parts of calamus, 10 parts of Chinese mahonia.
3. a kind of medicine for treating hepatitis B as claimed in claim 1 or 2, its preparation method comprise the following steps:
(1)Each bulk drug is taken by weight;
(2)Other bulk drugs in addition to rheum officinale are added in 6-8 times of water of medicinal material total amount, be cooked by slow fire 8-12 minutes, take Filtrate;8-10 times of water of medicinal material total amount is added, 18-22 minutes is cooked by slow fire, takes filtrate;Add the 8-10 of medicinal material total amount Times water, be cooked by slow fire 28-32 minutes, after rheum officinale under, take filtrate;It is well mixed to produce after inciting somebody to action filtrate merging three times.
CN201711079746.6A 2017-11-06 2017-11-06 A kind of medicine for treating hepatitis B and preparation method thereof Pending CN107802710A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
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Application Number Priority Date Filing Date Title
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1106690A (en) * 1994-11-19 1995-08-16 天津市第一医院 Medicine of curing hepatitis
KR101337525B1 (en) * 2011-10-07 2013-12-05 한국생명공학연구원 The Pharmaceutical compositions for prevention or treatment of hepatitis B containing extracts and fractions of Phyllanthus urinaria L and Hovenia dulcis Thunberg and Scutellaria baicalensis G. and Cinnamon as an active ingredient

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1106690A (en) * 1994-11-19 1995-08-16 天津市第一医院 Medicine of curing hepatitis
KR101337525B1 (en) * 2011-10-07 2013-12-05 한국생명공학연구원 The Pharmaceutical compositions for prevention or treatment of hepatitis B containing extracts and fractions of Phyllanthus urinaria L and Hovenia dulcis Thunberg and Scutellaria baicalensis G. and Cinnamon as an active ingredient

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Application publication date: 20180316