CN107802568A - A kind of oral cavity cleaning and nursing liquid of CRHD activity and preparation method thereof - Google Patents
A kind of oral cavity cleaning and nursing liquid of CRHD activity and preparation method thereof Download PDFInfo
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- CN107802568A CN107802568A CN201711211191.6A CN201711211191A CN107802568A CN 107802568 A CN107802568 A CN 107802568A CN 201711211191 A CN201711211191 A CN 201711211191A CN 107802568 A CN107802568 A CN 107802568A
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- oral cavity
- nursing liquid
- crhd
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- 210000000214 mouth Anatomy 0.000 title claims abstract description 45
- 239000007788 liquid Substances 0.000 title claims abstract description 31
- 230000000474 nursing effect Effects 0.000 title claims abstract description 30
- 238000004140 cleaning Methods 0.000 title claims abstract description 28
- 230000000694 effects Effects 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 41
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 40
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims abstract description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000011780 sodium chloride Substances 0.000 claims abstract description 20
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000004327 boric acid Substances 0.000 claims abstract description 19
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims abstract description 19
- 239000000920 calcium hydroxide Substances 0.000 claims abstract description 18
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims abstract description 18
- 241001116389 Aloe Species 0.000 claims abstract description 16
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims abstract description 16
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims abstract description 16
- 108090000526 Papain Proteins 0.000 claims abstract description 16
- 239000005844 Thymol Substances 0.000 claims abstract description 16
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 16
- 239000000174 gluconic acid Substances 0.000 claims abstract description 16
- 235000012208 gluconic acid Nutrition 0.000 claims abstract description 16
- 229960000790 thymol Drugs 0.000 claims abstract description 16
- 239000004365 Protease Substances 0.000 claims abstract description 15
- 229940055729 papain Drugs 0.000 claims abstract description 15
- 235000019834 papain Nutrition 0.000 claims abstract description 15
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229960003260 chlorhexidine Drugs 0.000 claims abstract description 13
- 239000008367 deionised water Substances 0.000 claims abstract description 12
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 12
- 230000001954 sterilising effect Effects 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 23
- 238000009835 boiling Methods 0.000 claims description 8
- 238000011049 filling Methods 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 3
- 235000007303 Thymus vulgaris Nutrition 0.000 claims description 2
- 239000001585 thymus vulgaris Substances 0.000 claims description 2
- 230000003750 conditioning effect Effects 0.000 claims 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 241000246358 Thymus Species 0.000 claims 1
- 238000005660 chlorination reaction Methods 0.000 claims 1
- 241000894006 Bacteria Species 0.000 abstract description 7
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 7
- 210000004400 mucous membrane Anatomy 0.000 abstract description 7
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 5
- 208000020670 canker sore Diseases 0.000 abstract description 5
- 210000003074 dental pulp Anatomy 0.000 abstract description 5
- 230000003211 malignant effect Effects 0.000 abstract description 4
- 210000001519 tissue Anatomy 0.000 abstract description 4
- 244000000010 microbial pathogen Species 0.000 abstract description 3
- 239000011782 vitamin Substances 0.000 abstract description 3
- 229940088594 vitamin Drugs 0.000 abstract description 3
- 229930003231 vitamin Natural products 0.000 abstract description 3
- 235000013343 vitamin Nutrition 0.000 abstract description 3
- 150000003722 vitamin derivatives Chemical class 0.000 abstract description 3
- 230000008595 infiltration Effects 0.000 abstract description 2
- 238000001764 infiltration Methods 0.000 abstract description 2
- 231100001231 less toxic Toxicity 0.000 abstract description 2
- 230000001151 other effect Effects 0.000 abstract description 2
- 230000036541 health Effects 0.000 description 10
- 230000014860 sensory perception of taste Effects 0.000 description 6
- 230000006870 function Effects 0.000 description 5
- 150000003384 small molecules Chemical class 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- -1 anthraquinone compounds Chemical class 0.000 description 4
- 230000011514 reflex Effects 0.000 description 4
- 244000131360 Morinda citrifolia Species 0.000 description 3
- 235000008898 Morinda citrifolia Nutrition 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000001143 conditioned effect Effects 0.000 description 3
- 238000002242 deionisation method Methods 0.000 description 3
- 208000030194 mouth disease Diseases 0.000 description 3
- 235000017524 noni Nutrition 0.000 description 3
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 208000025157 Oral disease Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- RGCKGOZRHPZPFP-UHFFFAOYSA-N alizarin Chemical compound C1=CC=C2C(=O)C3=C(O)C(O)=CC=C3C(=O)C2=C1 RGCKGOZRHPZPFP-UHFFFAOYSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000003862 health status Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 102000004310 Ion Channels Human genes 0.000 description 1
- 241001416180 Moschidae Species 0.000 description 1
- 241001263448 Mycetozoa Species 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000607764 Shigella dysenteriae Species 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 240000002657 Thymus vulgaris Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 244000290333 Vanilla fragrans Species 0.000 description 1
- 235000009499 Vanilla fragrans Nutrition 0.000 description 1
- 235000012036 Vanilla tahitensis Nutrition 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- RJWJHRPNHPHBRN-FKVJWERZSA-N aucubin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@@H]2C(CO)=C[C@@H](O)[C@@H]2C=CO1 RJWJHRPNHPHBRN-FKVJWERZSA-N 0.000 description 1
- UTDFQMAXCUGNJR-UHFFFAOYSA-N aucubin Natural products OCC1OC(Oc2ccoc2C3C(O)CCC3O)C(O)C(O)C1O UTDFQMAXCUGNJR-UHFFFAOYSA-N 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 230000008717 functional decline Effects 0.000 description 1
- 210000001126 granulation tissue Anatomy 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000000819 hypertonic solution Substances 0.000 description 1
- 229940021223 hypertonic solution Drugs 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 210000004261 periodontium Anatomy 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 210000001779 taste bud Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A kind of oral cavity cleaning and nursing liquid of CRHD activity and preparation method thereof, the invention belongs to oral cavity sterilizing product, a kind of less toxic pair, enriching yin clearing damp, readily soluble water, infiltration be strong, free from extraneous odour, safe and simple gargle to provide, and the technical scheme of oral cavity cleaning and nursing liquid offer of the present invention is：2 ~ 6 parts of gluconic acid chlorhexidine, 3 ~ 25 parts of promise Buddhist nun's ethanol gel, 1 ~ 5 part of thymol, 3 ~ 15 parts of papain gel, aloe gel 1:1 ~ 5 part, 0.5 5 parts of calcium hydroxide, 1 ~ 6 part of boric acid, 10 ~ 20 parts of sodium chloride, CRHD deionized water surpluses.Oral cavity of the present invention cleaning and nursing liquid has the function that antibacterial, anti-inflammatory in the oral cavity, removes dental pulp, improves the dissipation ability of pathogenic microorganism mucous membrane vitamin malignant bacteria in human oral cavity, optimize mucous membrane of mouth immuning tissue function, cure canker sore, various focusing depths represented, go to eliminate the unusual smell and other effects.Oral cavity of the present invention cleaning and nursing liquid safety, it is that market potential is huge with the environmentally friendly health-oriented products of consumers.
Description
Technical field
The invention belongs to oral cavity sterilizing product, and in particular to a kind of morinda citrifolia ethanol based on CRHD activity carries
Thing is taken, tooth tube wall pollution layer can be dispelled, cleans the oral cavity cleaning and nursing liquid of dental pulp.
Background technology
Science and technology and economic fast development, the rapid raising of social civilization and health perception, make the health of people's counterpart chamber
Nursing, cleaning and health care focus more on.Oral cavity is that food enters gastral important channel, and multiple-microorganism is lived away from home and bacterium
The particular surroundings of growth.Substantial amounts of beneficial and malignant bacteria is generally there are in " illness finds its way in by the mouth " oral cavity.The people of health is led to daily
Drinking-water feed, the activity such as gargle of brushing teeth are crossed, body immune system can be made to play anti-inflammatory sterilization, metabolic balance effect, maintenance function
Health.When people are with major disease or tired in Bad habits are in sub-health state, body autoimmune function declines
When, the microorganism remained in tooth pipe or the source of infection of dental pulp and intraoral pathogenic bacteria can amount reproduction, cause oral cavity it is unclean,
The symptoms such as inflammation, peculiar smell, canker sore, various focusing depths represented mouth disease.Oral cavity is the window of health, and " sense of taste conditioned reflex is with being good for
Health identification " CRHD can determine whether the health status of human body.China human mortality is numerous, the huge market demand, in recent years personal oral cleaning shield
The R＆D and production of reason product has reached 45% speedup, is focused more on attention by consumers in general, brand competition is further fierce.
Traditional oral cleaning-nursing liquid is such as：Physiological saline, sodium acid carbonate oral liquid, sodium chloride, potassium nitrate, peroxidating oxygen are molten
Liquid, or medical product is such as：Chlorohexidene, first nitre file etc., non-direct oral cavity doctor and dentist instruct, long-term use of function of not suiting the medicine to the illness
The single oral care product for having side effect, can also bring harm, make tooth stain be deposited on dental surface, influence the sense of taste, cause mouth
Intracavitary flora is unbalance, and the sense of the taste bud sense of taste reduces, and sensitivity of tooth degree lowers, and causes the malaise symptoms such as the dry, cusalgia of dry, tongue.Using
Normal saline solution carries out dentilave nursing, can form hypertonic solution after aqueous medium evaporation, sodium chloride material is collected at oral cavity
On mucous membrane tissue, periodontium is damaged, the inflammation such as mucosa hemorrhage occur.Therefore being capable of the fresh breath, beauty that takes care of one's teeth, right
Multiple oral disease have treatment, health-care effect, have to oral peculiar smell it is quick remove function, in a variety of contexts can safe ready
The oral-cavity cleaning products that fashion uses, it can all be favored by Market Consumer.
Morinda citrifolia（Nuo Ni）Contain aucubin, L2 asperulosides alizarin and anthraquinone compounds in fruit juice, can be effective
Prevent green pus vacation simple unicellular bacteria, mycetozoan, staphylococcus aureus, rod bacterium, Escherichia coli, detection of Salmonella and bacillus dysenteriae etc.
The infection of cell.These active antibacterial ingredients to treatment alleviate flu, heating, various focusing depths represented, canker sore, skin infection and its
He has significant curative effect because of bacterial disease.The ethanol extract of promise Buddhist nun can increase the shrinkage factor of wound ulcer, convergence
Energy and anti-microbial property, dental pulp is cleaned, the weight of the pollution of tooth lip wall, epithelium rate and the granulation tissue generated is removed, according to tradition
Tcm theory, Nuo Ni（Morinda citrifolia）With from the microcosmic equilibrium between yin and yang that human body is reconciled to macroscopic view, and to many different
Health problem（Disease）It is helpful so that its can have been given play in a different manner from a kind of single plant it is different
Effect.
CRHD（Based on human body " sense of taste conditioned reflex and health identification "）Structural system
“Conditional Reflex and Health Diagnostic based on taste”
Tested using the human body sense of taste to assess the structural system of human body health status, and obtained according to medical science and physiology promise prize
Person has found：" only small-micelle water could pass through 2 nanometers（nm）Human body cell ion channel, into nucleus and DNA, swash
Send out vitality, common pure water macromolecular mass can not be directly entered into the cell " discovery, prepared active water（Deionization
Water）.Ectoenzyme caused by mineral matter group in CRHD solution can effectively decompose the organic substance in thimerosal, and utilize release
The unique absorption property gone out promotes activation to optimize the beneficiating ingredients such as the skin care in disinfectant, sterilization, antibacterial, anti-inflammatory.It is environment-friendly
Type, antibacterial wide spectrum, quick-acting, bactericidal action is lasting；Less toxic pair, enriching yin clearing damp, readily soluble water, infiltration by force, it is free from extraneous odour, safe and simple,
It is preferred oral cavity cleaning and nursing class product market has been turned into.
The content of the invention
Offer of the invention is a kind of to remove tooth tube wall pollution layer, cleaning dental pulp, optimizes human oral cavity mucosa-immune tissue, be effective
The organic substance for making one easily to absorb in oral nursing liquid is decomposed, it is environmentally friendly, in a variety of environmental conditions, all conveniently make
With safe and simple, fashion oral cavity cleaning and nursing product.
The present invention is according to small in CRHD human bodies " sense of taste conditioned reflex identifies with health " principle and the CRHD modification aqueous solution
Molecule group beam（HZ）Ectoenzyme caused by mineral matter group can effectively decompose the active material Thief zone in mouth care solution
The characteristic such as attribute, absorption of human body of being more convenient for, rational proportion, overcome traditional oral care product make oral cavity flora imbalance, it is unbalance,
Antibacterial, anti-inflammatory effect deficiency, improve dissipation of the care agent to pathogenic microorganism mucous membrane vitamin malignant bacteria in human oral cavity
Function, mucous membrane of mouth immuning tissue is obtained healthy optimization, have to the treatment multiple oral disease such as canker sore and various focusing depths represented
Therapeutic action.
The present invention is accomplished in the following manner：Oral cavity cleaning and nursing liquid of the present invention, by the raw material group of following parts by weight
Into：2 ~ 6 parts of gluconic acid chlorhexidine, 3 ~ 25 parts of promise Buddhist nun's ethanol gel, 1 ~ 5 part of thymol, 3 ~ 15 parts of papain gel,
Aloe gel 1:1 ~ 5 part, calcium hydroxide 0.5-5 parts, 1 ~ 6 part of boric acid, 10 ~ 20 parts of sodium chloride, CRHD deionized water surpluses.Described
Promise Buddhist nun's ethanol gel is after being extracted using 75% ethanol, to remove the gel that ethanol obtains.
Oral cavity of the present invention cleaning and nursing liquid, preferably match the raw material composition of following parts by weight：Gluconic acid chlorhexidine 3
Part, 6 parts of promise Buddhist nun's ethanol gel, 2 parts of thyme, 5 parts of papain gel, 3 parts of aloe gel, 5 parts of calcium hydroxide, boric acid 6
Part, 15 parts of sodium chloride.
The preparation method of oral cavity of the present invention cleaning and nursing liquid, is prepared by following technique：Weigh the original of said ratio
Material, by gluconic acid chlorhexidine and promise Buddhist nun's ethanol gel, papain gel, aloe gel mixing 15 ~ 25 minutes, then by musk deer
Vanilla phenol is added in said mixture, is mixed 15 ~ 30 minutes, is eventually adding boric acid, sodium chloride and calcium hydroxide and is mixed into wherein, then
Mixture is added into 5000ml small molecules deionized water dissolving, filtering by proportioning, produced；Through 100 DEG C ~ 120 DEG C boiling water sterilizings one
Hour, filling 50ml/ branch, Different Package type " safe and simple oral cavity cleaning and nursing liquid " is made.
The preparation method of oral cavity of the present invention cleaning and nursing liquid, optimal preparation method are prepared by following technique：Weigh
The raw material of said ratio, by gluconic acid chlorhexidine and promise Buddhist nun's ethanol gel, papain gel, aloe gel, mixing 25
Minute, then thymol is added in said mixture, mix 20 minutes, be eventually adding boric acid, sodium chloride and calcium hydroxide mix
Close uniformly, add 5000ml small molecule deionized water dissolvings by proportioning after placing 30 minutes, filter and produce；Through 100 DEG C ~ 120 DEG C
Boiling water sterilizes one hour, filling 50ml/ branch, Different Package type system " safe and simple oral cavity cleaning and nursing liquid " is made.
Oral cavity of the present invention has antibacterial, anti-inflammatory with cleaning and nursing liquid, removes tooth tube wall pollution layer in the oral cavity, removes tooth
Marrow, improve the dissipation ability of pathogenic microorganism mucous membrane vitamin malignant bacteria in human oral cavity, optimization mucous membrane of mouth immuning tissue
Function, cures canker sore, various focusing depths represented, go to eliminate the unusual smell and other effects.Oral cavity of the present invention cleaning and nursing liquid, it is safe, portable, wide
Spectrum, efficiently, is that market potential is huge with the environmentally friendly health-oriented products of consumers.
Embodiment
Embodiment 1
（1）Raw material is weighed according to proportioning：Gluconic acid chlorhexidine 2g, promise Buddhist nun's ethanol gel 20g, thymol 3g, Papain
Enzyme gel 8g, aloe gel 4g, calcium hydroxide 5g, boric acid 4g, 10 ~ 20g of sodium chloride, appropriate deionized water；（2）By gluconic acid
Chlorhexidine, promise Buddhist nun's ethanol gel, papain gel and aloe gel are mixed 25 minutes, then thymol is added into above-mentioned mix
In compound, mix 15 minutes；（3）Add boric acid, sodium chloride and calcium hydroxide to be added thereto, then mixture is added by proportioning
5Kg deionized water dissolvings, filtering；（4）Sterilized one hour through 110 DEG C of boiling water, it is filling to obtain oral nursing liquid.
Embodiment 2
Weigh gluconic acid and determine 5g, promise Buddhist nun's ethanol gel 25g, thymol 3g, papain gel 15g, aloe gel
5g, calcium hydroxide 4g, boric acid 5g, sodium chloride 20g, mix 20 minutes, then thymol is added in said mixture, mixing 25
Minute, boric acid, sodium chloride and calcium hydroxide are eventually adding, then mixture is water-soluble by proportioning addition 5000ml small molecule deionizations
Solution, filtering, are produced.Sterilized one hour through 100 DEG C of boiling water, filling 50ml/ branch, Different Package type system " safe and simple mouth is made
Chamber cleaning and nursing liquid ".
Embodiment 3
Weigh gluconic acid and determine 3g, promise Buddhist nun's ethanol gel 20g, thymol 5g, papain gel 10g, aloe gel
5g, calcium hydroxide 4.5g, boric acid 8g, sodium chloride 16g, mix 25 minutes, then thymol is added in said mixture, mixing
15 minutes, boric acid, sodium chloride and calcium hydroxide are eventually adding, then mixture is added into 5000ml small molecule deionized waters by proportioning
Dissolving, filtering, is produced.Sterilized one hour through 120 DEG C of boiling water, filling 50ml/ branch, it is " safe and simple that Different Package type system is made
Oral cavity cleaning and nursing liquid ".
Embodiment 4
Weigh gluconic acid and determine 3g, promise Buddhist nun's ethanol gel 25g, thymol 3g, papain gel 15g, aloe gel
4g, calcium hydroxide 3g, boric acid 5g, sodium chloride 10g, mix 20 minutes, then thymol is added in said mixture, mixing 25
Minute, boric acid, sodium chloride and calcium hydroxide are eventually adding, then mixture is water-soluble by proportioning addition 5000ml small molecule deionizations
Solution, filtering, is produced.Sterilized one hour through 100 DEG C ~ 120 DEG C boiling water, filling 50ml/ branch, " the safety letter of Different Package type system is made
Just oral cavity cleaning and nursing liquid ".
Claims (4)
1. a kind of oral cavity cleaning and nursing liquid of CRHD activity, it is characterised in that described conditioning liquid includes following parts by weight thing
Matter：2 ~ 6 parts of gluconic acid chlorhexidine, 3 ~ 25 parts of promise Buddhist nun's ethanol gel, 1 ~ 5 part of thymol, 3 ~ 15 parts of papain gel,
Aloe gel 1:1 ~ 5 part, calcium hydroxide 0.5-5 parts, 1 ~ 6 part of boric acid, 10 ~ 20 parts of sodium chloride, deionized water 4000-6000 parts.
A kind of 2. oral cavity cleaning and nursing liquid of CRHD activity as claimed in claim 1, it is characterised in that described conditioning liquid bag
Following parts by weight material is included：3 parts of gluconic acid chlorhexidine, 6 parts of promise Buddhist nun's ethanol gel, 2 parts of thyme, papain gel
5 parts, 3 parts of aloe gel, 5 parts of calcium hydroxide, 6 parts of boric acid, 15 parts of sodium chloride, 5000 parts of deionized water.
3. a kind of preparation method of the oral cavity cleaning and nursing liquid of CRHD activity, it is characterised in that described preparation method is included such as
Lower step：（1）Raw material is weighed according to proportioning：2 ~ 6 parts of gluconic acid chlorhexidine, 3 ~ 25 parts of promise Buddhist nun's ethanol gel, thymol 1 ~ 5
Part, 3 ~ 15 parts of papain gel, aloe gel 1:1 ~ 5 part, calcium hydroxide 0.5-5 parts, 1 ~ 6 part of boric acid, sodium chloride 10 ~ 20
Part, deionized water 4000-6000 parts；（2）By gluconic acid chlorhexidine, promise Buddhist nun's ethanol gel, papain gel and aloe
Gel is mixed 15 ~ 25 minutes, then thymol is added in said mixture, is mixed 15 ~ 30 minutes；（3）Add boric acid, chlorination
Sodium and calcium hydroxide are added thereto, then mixture is added into appropriate deionized water dissolving, filtering by proportioning；（4）Through 100 DEG C ~
120 DEG C of boiling water sterilize one hour, filling to obtain oral nursing liquid.
4. a kind of preparation method of the oral cavity cleaning and nursing liquid of CRHD activity, it is characterised in that described preparation method is included such as
Lower step：（1）Raw material is weighed according to proportioning：2 ~ 6 parts of gluconic acid chlorhexidine, 3 ~ 8 parts of promise Buddhist nun's ethanol gel, thymol 1 ~ 5
Part, 3 ~ 5 parts of papain gel, aloe gel 1:1 ~ 5 part, calcium hydroxide 0.5-5 parts, 1 ~ 6 part of boric acid, 10 ~ 20 parts of sodium chloride,
Deionized water 4000-6000 parts；（2）By gluconic acid chlorhexidine, promise Buddhist nun's ethanol gel, papain gel and aloe gel
Mixing 25 minutes, then thymol is added in said mixture, mix 20 minutes；（3）Add boric acid, sodium chloride and hydroxide
Calcium is added thereto, then mixture is added to 5000ml deionized water dissolving by proportioning, filtering；（4）Through 100 DEG C ~ 120 DEG C boiling water
Sterilizing one hour, filling 50ml/ props up to obtain oral nursing liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711211191.6A CN107802568A (en) | 2017-11-28 | 2017-11-28 | A kind of oral cavity cleaning and nursing liquid of CRHD activity and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711211191.6A CN107802568A (en) | 2017-11-28 | 2017-11-28 | A kind of oral cavity cleaning and nursing liquid of CRHD activity and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107802568A true CN107802568A (en) | 2018-03-16 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711211191.6A Pending CN107802568A (en) | 2017-11-28 | 2017-11-28 | A kind of oral cavity cleaning and nursing liquid of CRHD activity and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110236968A (en) * | 2019-07-03 | 2019-09-17 | 深圳市诗碧曼科技有限公司 | A kind of antibacterial mouthwash of anti-ageing healthcare and preparation method thereof |
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| US20080184510A1 (en) * | 2005-06-03 | 2008-08-07 | Mauricio Duarte Da Conceicao | Products for Tongue Cleaning and for Preventing and Treaing Halitosis and Equipment for Tongue Cleaning |
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| CN106074305A (en) * | 2016-07-29 | 2016-11-09 | 广东俏脸谱文化艺术有限公司 | A kind of Noni fruit toothpaste with oral mucosa protective effect and preparation method thereof |
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2017
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| US20080184510A1 (en) * | 2005-06-03 | 2008-08-07 | Mauricio Duarte Da Conceicao | Products for Tongue Cleaning and for Preventing and Treaing Halitosis and Equipment for Tongue Cleaning |
| CN101410086A (en) * | 2006-03-29 | 2009-04-15 | 宝洁公司 | Oral care compositions having improved consumer aesthetics and taste |
| CN106074305A (en) * | 2016-07-29 | 2016-11-09 | 广东俏脸谱文化艺术有限公司 | A kind of Noni fruit toothpaste with oral mucosa protective effect and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110236968A (en) * | 2019-07-03 | 2019-09-17 | 深圳市诗碧曼科技有限公司 | A kind of antibacterial mouthwash of anti-ageing healthcare and preparation method thereof |
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Application publication date: 20180316 |