CN106176315B - A kind of mouthwash and preparation method thereof - Google Patents
A kind of mouthwash and preparation method thereof Download PDFInfo
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- CN106176315B CN106176315B CN201610739815.0A CN201610739815A CN106176315B CN 106176315 B CN106176315 B CN 106176315B CN 201610739815 A CN201610739815 A CN 201610739815A CN 106176315 B CN106176315 B CN 106176315B
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- mouthwash
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- plants essential
- essential oil
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- 239000002324 mouth wash Substances 0.000 title claims abstract description 124
- 229940051866 mouthwash Drugs 0.000 title claims abstract description 123
- 238000002360 preparation method Methods 0.000 title claims description 24
- 239000000341 volatile oil Substances 0.000 claims abstract description 71
- 239000000203 mixture Substances 0.000 claims abstract description 53
- 241000196324 Embryophyta Species 0.000 claims description 70
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 60
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 35
- 239000003921 oil Substances 0.000 claims description 32
- 235000019198 oils Nutrition 0.000 claims description 32
- 235000019441 ethanol Nutrition 0.000 claims description 30
- 239000004615 ingredient Substances 0.000 claims description 25
- 238000003756 stirring Methods 0.000 claims description 25
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 22
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 22
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims description 22
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 22
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims description 22
- 229940116229 borneol Drugs 0.000 claims description 22
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims description 22
- 229940041616 menthol Drugs 0.000 claims description 22
- 239000010619 basil oil Substances 0.000 claims description 21
- 229940018006 basil oil Drugs 0.000 claims description 21
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 18
- 235000019477 peppermint oil Nutrition 0.000 claims description 18
- 239000010624 camphor oil Substances 0.000 claims description 17
- 229960000411 camphor oil Drugs 0.000 claims description 17
- 239000010642 eucalyptus oil Substances 0.000 claims description 17
- 229940044949 eucalyptus oil Drugs 0.000 claims description 17
- 239000007788 liquid Substances 0.000 claims description 17
- 239000012153 distilled water Substances 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 11
- 239000006228 supernatant Substances 0.000 claims description 5
- 244000166124 Eucalyptus globulus Species 0.000 claims 1
- 240000002853 Nelumbo nucifera Species 0.000 claims 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 238000011282 treatment Methods 0.000 abstract description 16
- 230000000740 bleeding effect Effects 0.000 abstract description 15
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 12
- 208000030194 mouth disease Diseases 0.000 abstract description 10
- 230000001954 sterilising effect Effects 0.000 abstract description 7
- 201000001245 periodontitis Diseases 0.000 abstract description 6
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 6
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 abstract description 5
- 206010000269 abscess Diseases 0.000 abstract description 4
- 238000004140 cleaning Methods 0.000 abstract description 4
- 208000024891 symptom Diseases 0.000 abstract description 4
- 230000009471 action Effects 0.000 abstract description 3
- 230000036592 analgesia Effects 0.000 abstract description 3
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 58
- 235000013024 sodium fluoride Nutrition 0.000 description 29
- 239000011775 sodium fluoride Substances 0.000 description 29
- 238000012360 testing method Methods 0.000 description 12
- 241000894006 Bacteria Species 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- 230000036541 health Effects 0.000 description 7
- 210000000214 mouth Anatomy 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 208000007565 gingivitis Diseases 0.000 description 6
- 208000002193 Pain Diseases 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 206010006326 Breath odour Diseases 0.000 description 4
- 208000032139 Halitosis Diseases 0.000 description 4
- 241000194019 Streptococcus mutans Species 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 210000003298 dental enamel Anatomy 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000036407 pain Effects 0.000 description 4
- 230000000306 recurrent effect Effects 0.000 description 4
- 239000003507 refrigerant Substances 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 208000004371 toothache Diseases 0.000 description 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 230000000202 analgesic effect Effects 0.000 description 3
- 230000001139 anti-pruritic effect Effects 0.000 description 3
- 239000003908 antipruritic agent Substances 0.000 description 3
- 208000020670 canker sore Diseases 0.000 description 3
- 239000011737 fluorine Substances 0.000 description 3
- 229910052731 fluorine Inorganic materials 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- 206010028034 Mouth ulceration Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
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- 239000003205 fragrance Substances 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
- 229940060184 oil ingredients Drugs 0.000 description 2
- 230000001151 other effect Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 230000007958 sleep Effects 0.000 description 2
- 208000003265 stomatitis Diseases 0.000 description 2
- 229940034610 toothpaste Drugs 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 244000004281 Eucalyptus maculata Species 0.000 description 1
- 240000006927 Foeniculum vulgare Species 0.000 description 1
- 235000004204 Foeniculum vulgare Nutrition 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000007265 Myrrhis odorata Nutrition 0.000 description 1
- 235000010676 Ocimum basilicum Nutrition 0.000 description 1
- 240000007926 Ocimum gratissimum Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 240000004760 Pimpinella anisum Species 0.000 description 1
- 235000012550 Pimpinella anisum Nutrition 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- 206010048211 Xanthelasma Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
- 230000000146 antalgic effect Effects 0.000 description 1
- 230000000675 anti-caries Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001857 anti-mycotic effect Effects 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 230000003260 anti-sepsis Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000002543 antimycotic Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000010692 aromatic oil Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000009109 curative therapy Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000010643 fennel seed oil Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000032724 odontogenesis Effects 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 239000010676 star anise oil Substances 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 229960001957 stomatological preparations Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Birds (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of mouthwash, the mouthwash includes plants essential oil mixture and NaF.Mouthwash of the present invention has the double action of cleaning, treatment, both the characteristic of traditional fluoride mouthwash had been maintained, plants essential oil mixture is increased on the basis of traditional mouthwash again, so that mouthwash is had the function of sterilization, anti-inflammatory, analgesia, fresh breath, and the mouth disease of the symptoms such as saprodontia, periodontitis, bleeding gums, abscess of throat can be assisted in the treatment of.
Description
Technical field
The invention belongs to oral health care field, especially a kind of mouthwash and preparation method thereof.
Background technique
In order to solve this simple question of halitosis, various methods are used, such as brushes teeth more, chew gum, eating tea
Leaf etc..Though these methods can also achieve the effect that certain, but not ideal enough, some is also inconvenient.As people live
Horizontal raising and the continuous pursuit to beauty, oral hygiene and oral health become one of modern's focus of attention.
Sooner or later brushing teeth twice is no longer confined to for the nursing of oral hygiene, mouthwash is carried and has become a kind of fashion, gargle
Saliva plays the part of more and more important role in daily life.Mouthwash is the novel product of Technology Times, a variety for the treatment of mouths
Chamber, pharyngolaryngitis drug ingedient match, while treating mouth disease, can also remove because of mouth disease, eat peculiar smell foodstuff, sleep
It sleeps halitosis caused by bad, nervous, indigestion etc..
Daily oral health care is for preventing and controlling mouth disease (saprodontia, gingivitis, the periodontal of bacterial plaque correlation
Disease) it plays an important role.The bacterium for inhibiting the formation of bacterial plaque using effective chemicals or killing in bacterial plaque is control bacterium
Another effective way of spot.It is gargled with oil, because the adhesion of oil is high, is easier to be full of Buccodental, gum and mucous membrane than water,
And bacterium has lipophilicity, oil is easier that bacterium is allowed to be melted into wherein than water, and penetrates sublingual absorption, takes the nutrition of oil to blood rapidly
In liquid, and by blood bacterium and toxin be discharged in oil.Oil, which is gargled, provides a good method, improves oral cavity and body system
The health of system.
Summary of the invention
Based on this, provided a kind of containing plant essence it is an object of the invention to overcome above-mentioned the deficiencies in the prior art place
Oil has cleaning, the mouthwash for the treatment of double action and preparation method thereof.
To achieve the above object, the technical solution used in the present invention are as follows: a kind of mouthwash, the mouthwash include plant
Blend of essential oils and NaF.
Preferably, weight percent of the plants essential oil mixture in the mouthwash is 1~20%, the NaF
Weight percent in the mouthwash is 0.01%~0.1%.
Preferably, weight percent of the NaF in the mouthwash is 0.05%.
Fluorine is necessary for human health a kind of microelement, its wide hair ground is present in nature, we can daily
Fluoride is taken in by approach such as drinking-water, food, air.As other the essential trace elements of the human bodys, sodium fluoride is to human body
Effect it is related with dosage, have a physiological action when taking in optimal dose, to the toxic effect of human health when excess intake.Fluorine is
A kind of cumulative toxicant, excessive fluorine are absorbed, and will lead to deformity teeth, softening, enamel tarnish, and with xanthelasma
Point, severe one tooth development is not complete, loses normal morphology.Suitable sodium fluoride can be effectively prevented saprodontia, and mechanism is to oral cavity
A variety of enzymes have inhibiting effect, can be antibacterial, reduce bacterial plaque, can reduce the solubility of hydroxyapatite in enamel, increase tooth
Anti-caries power can also promote the integrality of enamel, increase the hardness of enamel.Plants essential oil not only possesses the smell of smelling good, also together
When have good bactericidal antiphlogistic, treat oral cavity disease the effect of.It gargles and provides a kind of good method, it can be permeated
To the inside of plaque bio-film, there is significant killing effect to oral bacteria.Mouthwash of the present invention, both maintains tradition
The characteristic of fluoride mouthwash, fluoride provide additional protection for tooth, are effectively prevented decayed tooth, and gargle in traditional
Plants essential oil mixture is increased on the basis of water, and mouthwash is made to have the function of sterilization, anti-inflammatory, analgesia, fresh breath, and energy
Enough pre- preventing parodontitis, bleeding gums, halitosis, saprodontia, mouth disease.Therefore on the basis of traditional mouthwash, addition plant essence
The novel mouth wash water that oil is fabricated to has good application value.
Preferably, the plants essential oil mixture comprises the following components in parts by weight: 0.1~1.5 part of borneol, Chinese anise
Oily 1~5 part, 1~10 part of eucalyptus oil, 10~50 parts of camphor oil, 10~70 parts of gaultherolin, 1~5 part of basil oil, peppermint oil
10~70 parts, 1~5 part of menthol.
Preferably, the plants essential oil mixture comprises the following components in parts by weight: 0.1~1 part of borneol, oil of badian
1~3 part, 4~7 parts of eucalyptus oil, 10~25 parts of camphor oil, 30~50 parts of gaultherolin, 1~3 part of basil oil, peppermint oil 25~
50 parts, 2~3 parts of menthol.
Preferably, the plants essential oil mixture comprises the following components in parts by weight: 0.3 part of borneol, oil of badian 2.7
Part, 5.4 parts of eucalyptus oil, 20.1 parts of camphor oil, 33.4 parts of gaultherolin, 2.0 parts of basil oil, 33.4 parts of peppermint oil, menthol
2.7 part.
In plants essential oil mixture of the present invention, borneol energy inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain, anti-inflammation and sterilization, to ulcer
Property stomatitis, throat ability to speak swelling and pain etc. mouth diseases have original preventive and therapeutic action；There is eucalyptus oil wind-expelling pain-stopping, anti-inflammatory to press down
The effect of bacterium；Oil of badian, the aromatic oil extracted from octagonal branch, leaf, fruit boiling, is commonly called as fennel oil or star anise oil, has
Fennel, Radix Glycyrrhizae, isoesdragol fragrance, there is certain antibacterial action；Peppermint oil is the fresh stem and Ye Jingshui by plant peppermint
The essential oil that steam distillation obtains has special refrigerant fragrance, and there is refrigerant antipruritic, anti-inflammatory analgetic, mitigation edema, sterilization, restoring consciouness to mention
Mind and other effects；Menthol can be used in treatment toothache, oral mucositis with refrigerant antipruritic, anti-inflammatory and antalgic, antibacterial, antiviral；
Basil oil has anti-inflammatory antisepsis, can be used for the treatment of saprodontia；Methyl salicylate being capable of antimycotic, anti-inflammatory, detumescence, town
It is bitterly antipruritic, refresh oneself, clinic be also used for treatment toothache.It is mixed with above-mentioned 7 kinds of plants essential oils plants essential oil made of selected parts by weight
It closes object to be used to prepare in mouthwash, the applicant has been surprisingly found that the mouthwash is refrigerant with fragrant odour, anti-inflammatory is antibacterial and analgesic
Effect, and the various mouth diseases such as toothache, bleeding gums, periodontitis, canker sore, abscess of throat, saprodontia can be assisted in the treatment of,
Alleviate the uncomfortable symptom in various oral cavities.
Preferably, the mouthwash also includes ethyl alcohol, weight percent of the ethyl alcohol in the mouthwash be 5~
25%.
In the told plants essential oil mouthwash of the present invention, ethyl alcohol is primarily to allow menthol, eucalyptus oil etc. in mouthwash
Plant-derived essential oil plays a role, and permeates and decompose plaque.In addition, ethyl alcohol can also be used as cosolvent, enhance the molten of composition
Xie Du increases the transparency of mouthwash.It is highly preferred that the mouthwash also includes sorbierite, the sorbierite is gargled described
Weight percent in water is 5~25%.
In plants essential oil mouthwash of the present invention, sorbierite improves the mouthfeel of mouthwash as sweetener.Sorbierite
Sugariness is lower than sucrose, and is not utilized by certain bacteriums, in addition, sorbierite is added in mouthwash, has certain work to prevention and treatment saprodontia
With.Meanwhile the present invention also provides a kind of preparation method of mouthwash, the methods are as follows: by the mouthwash ingredient
It carries out uniformly mixed, distilled water is added and futher stirs and is mixed into supernatant liquid, obtains the mouthwash.
In addition, the present invention also provides the preparation method of mouthwash as described above, the method are as follows: the mouthwash is each
Ingredient is uniformly mixed, and addition distilled water, which futher stirs, is mixed into supernatant liquid to get the mouthwash.
It is highly preferred that the method are as follows: after mixing by plants essential oil mixture each component, it is added in ethyl alcohol, then
NaF is added, dissolution is mixed, is eventually adding distilled water and is stirred into supernatant liquid, obtain the mouthwash；
Or
After mixing by plants essential oil mixture each component, it is added in ethyl alcohol, adds NaF and sorbierite mixing is stirred
Dissolution is mixed, distilled water is eventually adding and is stirred into supernatant liquid, obtains the mouthwash.
Compared with the existing technology, the invention has the benefit that the present invention provides one kind to have cleaning, treats dual work
Mouthwash containing plants essential oil reinforces the work of anti-inflammatory, sterilization, analgesic on the basis of taking care of one's teeth, cleaning oral hygiene
With the mouth disease of the symptoms such as adjuvant treatment saprodontia, periodontitis, bleeding gums, abscess of throat；It is of the present invention to contain plants essential oil
Mouthwash, not only maintained the characteristic of traditional fluoride mouthwash, but also increase on the basis of traditional mouthwash plant essence
Oil mixture makes mouthwash have the function of sterilization, anti-inflammatory, analgesia, fresh breath, and can pre- preventing parodontitis, gum go out
Blood, halitosis, saprodontia, mouth disease.
Specific embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Embodiment 1
A kind of embodiment of mouthwash of the present invention, mouthwash described in the present embodiment include the ingredient of following weight percent:
Plants essential oil mixture 2%, NaF 0.05%, ethyl alcohol 15%, sorbierite 15%, surplus are water；
Wherein, the plants essential oil mixture comprises the following components in parts by weight: 0.3 part of borneol, oil of badian 2.7
Part, 5.4 parts of eucalyptus oil, 20.1 parts of camphor oil, 33.4 parts of gaultherolin, 2.0 parts of basil oil, 33.4 parts of peppermint oil, menthol
2.7 part.
Mouthwash described in the present embodiment the preparation method comprises the following steps:
By above-mentioned weight, each ingredient of plants essential oil mixture is uniformly mixed, is then added in ethyl alcohol and stirs
It is uniformly mixed, adds that NaF, sorbierite stirring and dissolving are uniform, and finally plus distilled water is stirred into clear liquid to get institute
State mouthwash.
Embodiment 2
A kind of embodiment of mouthwash of the present invention, mouthwash described in the present embodiment include the ingredient of following weight percent:
Plants essential oil mixture 5%, NaF 0.05%, ethyl alcohol 10%, sorbierite 19%, surplus are water；
Wherein, the plants essential oil mixture comprises the following components in parts by weight: 0.3 part of borneol, oil of badian 2.7
Part, 5.4 parts of eucalyptus oil, 20.1 parts of camphor oil, 33.4 parts of gaultherolin, 2.0 parts of basil oil, 33.4 parts of peppermint oil, menthol
2.7 part.
Mouthwash described in the present embodiment the preparation method comprises the following steps:
By above-mentioned weight, each ingredient of plants essential oil mixture is uniformly mixed, is then added in ethyl alcohol and stirs
It is uniformly mixed, adds that NaF, sorbierite stirring and dissolving are uniform, and finally plus distilled water is stirred into clear liquid to get institute
State mouthwash.
Embodiment 3
A kind of embodiment of mouthwash of the present invention, mouthwash described in the present embodiment include the ingredient of following weight percent:
Plants essential oil mixture 8%, NaF 0.05%, ethyl alcohol 20%, sorbierite 8%, surplus are water；
Wherein, the plants essential oil mixture comprises the following components in parts by weight: 0.3 part of borneol, oil of badian 2.7
Part, 5.4 parts of eucalyptus oil, 20.1 parts of camphor oil, 33.4 parts of gaultherolin, 2.0 parts of basil oil, 33.4 parts of peppermint oil, menthol
2.7 part.
Mouthwash described in the present embodiment the preparation method comprises the following steps:
By above-mentioned weight, each ingredient of plants essential oil mixture is uniformly mixed, is then added in ethyl alcohol and stirs
It is uniformly mixed, adds that NaF, sorbierite stirring and dissolving are uniform, and finally plus distilled water is stirred into clear liquid to get institute
State mouthwash.
Embodiment 4
A kind of embodiment of mouthwash of the present invention, mouthwash described in the present embodiment include the ingredient of following weight percent:
Plants essential oil mixture 10%, NaF 0.05%, ethyl alcohol 18%, sorbierite 20%, surplus are water；
Wherein, the plants essential oil mixture comprises the following components in parts by weight: 0.3 part of borneol, oil of badian 2.7
Part, 5.4 parts of eucalyptus oil, 20.1 parts of camphor oil, 33.4 parts of gaultherolin, 2.0 parts of basil oil, 33.4 parts of peppermint oil, menthol
2.7 part.
Mouthwash described in the present embodiment the preparation method comprises the following steps:
By above-mentioned weight, each ingredient of plants essential oil mixture is uniformly mixed, is then added in ethyl alcohol and stirs
It is uniformly mixed, adds that NaF, sorbierite stirring and dissolving are uniform, and finally plus distilled water is stirred into clear liquid to get institute
State mouthwash.
Embodiment 5
A kind of embodiment of mouthwash of the present invention, mouthwash described in the present embodiment include the ingredient of following weight percent:
Plants essential oil mixture 15%, NaF 0.05%, ethyl alcohol 19%, sorbierite 10%, surplus are water；
Wherein, the plants essential oil mixture comprises the following components in parts by weight: 0.3 part of borneol, oil of badian 2.7
Part, 5.4 parts of eucalyptus oil, 20.1 parts of camphor oil, 33.4 parts of gaultherolin, 2.0 parts of basil oil, 33.4 parts of peppermint oil, menthol
2.7 part.
Mouthwash described in the present embodiment the preparation method comprises the following steps:
By above-mentioned weight, each ingredient of plants essential oil mixture is uniformly mixed, is then added in ethyl alcohol and stirs
It is uniformly mixed, adds that NaF, sorbierite stirring and dissolving are uniform, and finally plus distilled water is stirred into clear liquid to get institute
State mouthwash.
Embodiment 6
A kind of embodiment of mouthwash of the present invention, mouthwash described in the present embodiment include the ingredient of following weight percent:
Plants essential oil mixture 20%, NaF 0.1%, ethyl alcohol 25%, sorbierite 20%, surplus are water；
Wherein, the plants essential oil mixture comprises the following components in parts by weight: 0.3 part of borneol, oil of badian 2.7
Part, 5.4 parts of eucalyptus oil, 20.1 parts of camphor oil, 33.4 parts of gaultherolin, 2.0 parts of basil oil, 33.4 parts of peppermint oil, menthol
2.7 part.
Mouthwash described in the present embodiment the preparation method comprises the following steps:
By above-mentioned weight, each ingredient of plants essential oil mixture is uniformly mixed, is then added in ethyl alcohol and stirs
It is uniformly mixed, adds that NaF, sorbierite stirring and dissolving are uniform, and finally plus distilled water is stirred into clear liquid to get institute
State mouthwash.
Embodiment 7
A kind of embodiment of mouthwash of the present invention, mouthwash described in the present embodiment include the ingredient of following weight percent:
Plants essential oil mixture 1%, NaF 0.01%, ethyl alcohol 20%, sorbierite 5%, surplus are water；
Wherein, the plants essential oil mixture comprises the following components in parts by weight: 0.3 part of borneol, oil of badian 2.7
Part, 5.4 parts of eucalyptus oil, 20.1 parts of camphor oil, 33.4 parts of gaultherolin, 2.0 parts of basil oil, 33.4 parts of peppermint oil, menthol
2.7 part.
Mouthwash described in the present embodiment the preparation method comprises the following steps:
By above-mentioned weight, each ingredient of plants essential oil mixture is uniformly mixed, is then added in ethyl alcohol and stirs
It is uniformly mixed, adds that NaF, sorbierite stirring and dissolving are uniform, and finally plus distilled water is stirred into clear liquid to get institute
State mouthwash.
Embodiment 8
A kind of embodiment of mouthwash of the present invention, mouthwash described in the present embodiment include the ingredient of following weight percent:
Plants essential oil mixture 18%, NaF 0.06%, ethyl alcohol 5%, sorbierite 25%, surplus are water；
Wherein, the plants essential oil mixture comprises the following components in parts by weight: 0.1 part of borneol, 1 part of oil of badian,
1 part of eucalyptus oil, 10 parts of camphor oil, 10 parts of gaultherolin, 1 part of basil oil, 10 parts of peppermint oil, 1 part of menthol.
Mouthwash described in the present embodiment the preparation method comprises the following steps:
By above-mentioned weight, each ingredient of plants essential oil mixture is uniformly mixed, is then added in ethyl alcohol and stirs
It is uniformly mixed, adds that NaF, sorbierite stirring and dissolving are uniform, and finally plus distilled water is stirred into clear liquid to get institute
State mouthwash.
Embodiment 9
A kind of embodiment of mouthwash of the present invention, mouthwash described in the present embodiment include the ingredient of following weight percent:
Plants essential oil mixture 12%, NaF 0.05%, ethyl alcohol 11%, sorbierite 15%, surplus are water；
Wherein, the plants essential oil mixture comprises the following components in parts by weight: 1 part of borneol, 3 parts of oil of badian, eucalyptus
Oily 4 parts, 25 parts of camphor oil, 30 parts of gaultherolin, 3 parts of basil oil, 25 parts of peppermint oil, 2 parts of menthol.
Mouthwash described in the present embodiment the preparation method comprises the following steps:
By above-mentioned weight, each ingredient of plants essential oil mixture is uniformly mixed, is then added in ethyl alcohol and stirs
It is uniformly mixed, adds that NaF, sorbierite stirring and dissolving are uniform, and finally plus distilled water is stirred into clear liquid to get institute
State mouthwash.
Embodiment 10
A kind of embodiment of mouthwash of the present invention, mouthwash described in the present embodiment include the ingredient of following weight percent:
Plants essential oil mixture 8%, NaF 0.05%, ethyl alcohol 20%, surplus are water；
Wherein, the plants essential oil mixture comprises the following components in parts by weight: 1.5 parts of borneol, 5 parts of oil of badian,
7 parts of eucalyptus oil, 50 parts of camphor oil, 50 parts of gaultherolin, 5 parts of basil oil, Peppermint Oil 50 part, 3 parts of menthol.
Mouthwash described in the present embodiment the preparation method comprises the following steps:
By above-mentioned weight, each ingredient of plants essential oil mixture is uniformly mixed, is then added in ethyl alcohol and stirs
It is uniformly mixed, adds that NaF stirring and dissolving is uniform, and finally plus distilled water is stirred into clear liquid and gargles to get described
Water.
Embodiment 11
A kind of embodiment of mouthwash of the present invention, mouthwash described in the present embodiment include the ingredient of following weight percent:
Plants essential oil mixture 15%, NaF 0.05%, ethyl alcohol 12%, surplus are water；
Wherein, the plants essential oil mixture comprises the following components in parts by weight: 0.5 part of borneol, 2 parts of oil of badian,
10 parts of eucalyptus oil, 35 parts of camphor oil, 70 parts of gaultherolin, 2.5 parts of basil oil, Peppermint Oil 70 part, 5 parts of menthol.
Mouthwash described in the present embodiment the preparation method comprises the following steps:
By above-mentioned weight, each ingredient of plants essential oil mixture is uniformly mixed, is then added in ethyl alcohol and stirs
It is uniformly mixed, adds that NaF stirring and dissolving is uniform, and finally plus distilled water is stirred into clear liquid and gargles to get described
Water.
Embodiment 12
In order to further prove that the mouthwash is antibacterial with anti-inflammatory, relieve pain, and toothache, bleeding gums, tooth can be assisted in the treatment of
Zhou Yan, canker sore, abscess of throat and treatment saprodontia and other effects, the research of the present embodiment Binding experiment illustrate that plants essential oil is gargled
Inhibitory effect of the saliva to adult plaque and gingivitis.
1, test medicine and grouping
Control group: mouthwash (is free of borneol, 4 kinds of menthol, basil oil and oil of badian essential oils, other preparations
Method and provided by the invention consistent)；
Test group: the mouthrinse product provided by allocation of the present invention and preparation method.
2, research object and grouping
60 medical gingivitis patients of selection stomatological hospital, the age -45 years old 18 years old.Wherein male 26, women 34.
Meet following condition: in order, full mouth must not be less than 20 function teeth to whole body health；Gum is red and swollen, hence it is evident that bleeding is examined in spy；From
It is willing to participate in this research, and the cavity care product that this research provides is used only；Antibiotic, hormone were not taken in 3 months；Nothing
Systemic disease.
60 gingivitis, bleeding gums patient are randomly divided into test group and control group (every group 30), and test group is daily
Contain mouthwash by grouping requirements after early, evening basic oral care is complete, contain gargle 20ml every time, lasting 30s gargles in 30 minutes not
Obtain diet.2 groups of subjects require to use unified toothpaste and toothbrush, should cover toothbrush head using the length of toothpaste every time, often
Secondary 2 minutes.Continue one-month period.
2.2 check criteria
Every subject checks 6 tooth positions (16,21,24,36,41,44), and each tooth checks 4 sites: in close, center,
Cheek side and center tongue side in remote, detection records plaque index (PLI), gingival index (GI), bleeding index (BI) respectively, and takes
Clinical index of the average value as the index.
2.3 result
When 2 week and 1 month, plaque index, gingival index and the bleeding index inspection result difference of 2 groups of patients affected by inspection
It is shown in Table 1,2,3.
1 test group of table and control group plaque index compare
2 test group of table and control group gingival index compare
3 test group of table and control group bleeding index compare
From table 1,2,3 as can be seen that using plants essential oil mouthwash test group compared with the control group, when 2 week, bacterium
Spot index, gingival index and bleeding index reduce 7.05%, 11.79%, 31.51% compared with control group respectively；When 4 week,
Plaque index, gingival index and bleeding index reduce 30.39%, 38.67%, 42.11% compared with control group respectively.Use plant
Compared with the test group of essential oil mouthwash is when baseline, plaque index reduces 17.31% He respectively when 2 week and 1 month
79.41, gingival index reduces 14.45% and 66.30% respectively, and bleeding index reduces 35.62% and 73.68% respectively.
Thus data can be seen that the mouthwash provided by the invention containing plants essential oil has the oral problems such as gingivitis, bleeding gums
More apparent therapeutic effect can be used as the secondary articles of common oral care.In addition, borneol, menthol, clore basil
For the mouthwash of oil and 4 kinds of plants essential oils of oil of badian than what is be free of, restraining and sterilizing bacteria, hemostasis and the effect for the treatment of gingivitis are more aobvious
It writes.
Embodiment 13
The present embodiment researchs and analyses therapeutic effect of the mouthwash prepared by the present invention to recurrent oral ulceration.
1, general information: choose Blood of Patients with Recurrent Oral 40, wherein male 25, female 15, based on control, it is double
This group of patient is divided into two groups by blind, random principle, is observation group (20) and control group (20) respectively.The disease of two groups of patients
Feelings, age, gender etc. are comparable, and statistical significance is not present.
2, method: control group patient gives the treatment of vitamin B2 piece, and 3 times a day, 2 tablets once.And this hair is given by observation group
The plants essential oil mouthwash of bright offer is treated, 2-3 times daily, each 20ml or so.The equal continued treatment of two groups of patients 20 days.
3, efficacy evaluation: effective: local cusalgia disappears, ulcer surface heals comprehensively, follow-up 6 months without recurrence.It is effective: follow-up
It is recurred in 6 months, but the recurrence intermittent phase extends, local cusalgia is substantially reduced, ulcer surface is alleviated, recurrent number is reduced.
Invalid: clinical symptoms are not alleviated, or even deteriorate.
4, the results are shown in Table 4
4 two groups of patients after curative treatment of table compare
As can be seen from Table 4, observation group is effective 7 (35.0%), effective 12 (60.0%), invalid 1 (5.0%),
Total effective rate 95.0%；Control group is effective 3 (15.0%), effective 12 (60.0%), invalid 5 (25.0%), total effective
Rate 75.0%, effective percentage has more apparent difference after two groups of patient's treatments, in view of this plants essential oil provided by the invention
Mouthwash has good curative effect for the treatment of recurrent oral ulceration, and it is swollen to can effectively reduce patient's canker sore, throat
The oral problem of pain.
Embodiment 14
The present embodiment carries out experimental study analysis to effect of the mouthwash of the present invention in terms of preventing decayed tooth.
Experimental method: choosing 30 people of volunteer, be randomly divided into three groups, respectively with plants essential oil mouthwash of the present invention (test
Group A: its mouthwash composition and preparation method and the embodiment of the present invention 4 are consistent, experiment group B: its mouthwash composition and preparation method
It is consistent with the embodiment of the present invention 9), control group (borneol, menthol, basil oil and oil of badian are not contained in mouthwash,
Other components weight ratio and preparation method and embodiment 4 are consistent) 1 month by a definite date preventing decayed tooth Germicidal efficacy is carried out, it has brushed sooner or later daily
After tooth, 20ml containing mouthwash continues 30s.Observed content is the percentage of the total anaerobic bacteria of streptococcus mutans Zhan before and after experiment.
It the results are shown in Table 5.
5 preventing decayed tooth measuring result of table
It is shown according to measurement result, there is different degrees of streptococcus mutans proportion after test group and control group experiment
Decline, but the decline of two group ratios has notable difference again, and test group A, B down ratio is respectively 70.8% and 68.7%, and right
42.1% is then had dropped according to group, the water energy that illustrates to gargle effectively kills the streptococcus mutans in oral cavity, can obviously inhibit plaque
The growth of middle streptococcus mutans, and play the role of specific preventing decayed tooth.
The experimental study data of integrated embodiment 12~14, the plants essential oil mouthwash which provides, which has, significantly to kill
Bacterium effect, and has the function of anti-inflammatory, fresh air, can be used to prevent or treat periodontitis, bleeding gums, saprodontia or other
Mouth disease.In addition, obtaining according to experimental study, contain borneol, menthol, basil oil and 4 kinds of oil of badian
The mouthwash of plants essential oil, on preventing and treating oral problem various aspects curative effect, effect is more significant, and healing is faster.Therefore at this
In the preparation process of invention mouthwash, we joined plants essential oil mixture, in order to enhance therapeutic effect, and by
There is aromatic odor in plants essential oil, play the function of fresh breath, can also make mouthwash that there is better mouthfeel, be easy to be disappeared
Expense person is received.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.
Claims (6)
1. a kind of mouthwash, which is characterized in that the mouthwash includes plants essential oil mixture and NaF；The plants essential oil is mixed
Closing weight percent of the object in the mouthwash is 1~20%, and weight percent of the NaF in the mouthwash is
0.01%~0.1%；
The plants essential oil mixture comprises the following components in parts by weight: 0.1~1.5 part of borneol, 1~5 part of oil of badian, eucalyptus
It is 1~10 part of oil, 10~50 parts of camphor oil, 10~70 parts of gaultherolin, 1~5 part of basil oil, 10~70 parts of peppermint oil, thin
1~5 part of lotus brain.
2. mouthwash as described in claim 1, which is characterized in that the plants essential oil mixture includes the group of following parts by weight
Point: 0.1~1 part of borneol, 1~3 part of oil of badian, 4~7 parts of eucalyptus oil, 10~25 parts of camphor oil, 30~50 parts of gaultherolin,
1~3 part of basil oil, 25~50 parts of peppermint oil, 2~3 parts of menthol.
3. mouthwash as claimed in claim 2, which is characterized in that the plants essential oil mixture includes the group of following parts by weight
Point: 0.3 part of borneol, 2.7 parts of oil of badian, 5.4 parts of eucalyptus oil, 20.1 parts of camphor oil, 33.4 parts of gaultherolin, basil oil
2.0 parts, 33.4 parts of peppermint oil, 2.7 parts of menthol.
4. the mouthwash as described in claims 1 to 3 is any, which is characterized in that the mouthwash also includes ethyl alcohol, the ethyl alcohol
Weight percent in the mouthwash is 5~25%.
5. mouthwash as claimed in claim 4, which is characterized in that the mouthwash also includes sorbierite, and the sorbierite exists
Weight percent in the mouthwash is 5~25%.
6. a kind of preparation method of the mouthwash as described in Claims 1 to 5 is any, which is characterized in that the method are as follows: by institute
It states each ingredient of mouthwash to be uniformly mixed, addition distilled water, which futher stirs, is mixed into supernatant liquid to get the mouthwash.
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| CN107496246A (en) * | 2017-09-15 | 2017-12-22 | 南通荣成医药化工有限公司 | A kind of antiemetic mouthwash |
| CN109464574A (en) * | 2018-12-28 | 2019-03-15 | 广东罗浮山国药股份有限公司 | A kind of application of Chinese medicine composition in the drug of preparation treatment canker sore |
| CN116172886A (en) * | 2022-06-29 | 2023-05-30 | 广州何济堂生物科技有限公司 | Mouthwash and preparation method thereof |
| CN115607488A (en) * | 2022-09-26 | 2023-01-17 | 喜德县元升农业科技有限公司 | A collutory containing Olea europaea extract |
| CN116785203A (en) * | 2023-07-14 | 2023-09-22 | 威莱(广州)日用品有限公司 | Mouthwash containing natural plant essential oil composition and preparation method thereof |
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| CN102512345A (en) * | 2011-12-28 | 2012-06-27 | 美晨集团股份有限公司 | Natural antibacterial gargle and preparation method thereof |
| KR20140104329A (en) * | 2013-02-20 | 2014-08-28 | 장성군 | Composition for mouth washing agent comprising cypress extract and cypress essential oil, and manufacturing method thereof |
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