CN107760452A - A kind of contact lens care solution - Google Patents
A kind of contact lens care solution Download PDFInfo
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- CN107760452A CN107760452A CN201710978160.7A CN201710978160A CN107760452A CN 107760452 A CN107760452 A CN 107760452A CN 201710978160 A CN201710978160 A CN 201710978160A CN 107760452 A CN107760452 A CN 107760452A
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- Prior art keywords
- parts
- contact lens
- lens care
- phosphatide
- care solution
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- 239000000243 solution Substances 0.000 claims abstract description 54
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 28
- 239000007788 liquid Substances 0.000 claims abstract description 24
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 16
- 239000000203 mixture Substances 0.000 claims abstract description 16
- 239000003899 bactericide agent Substances 0.000 claims abstract description 15
- 239000008139 complexing agent Substances 0.000 claims abstract description 15
- 238000003756 stirring Methods 0.000 claims abstract description 15
- 239000006185 dispersion Substances 0.000 claims abstract description 14
- 230000003204 osmotic effect Effects 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000002504 physiological saline solution Substances 0.000 claims abstract description 13
- 230000008014 freezing Effects 0.000 claims abstract description 7
- 238000007710 freezing Methods 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 25
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
- 238000010257 thawing Methods 0.000 claims description 20
- 239000002904 solvent Substances 0.000 claims description 15
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 14
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 14
- -1 polyoxyethylene Polymers 0.000 claims description 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 11
- 239000000787 lecithin Substances 0.000 claims description 11
- 229940067606 lecithin Drugs 0.000 claims description 11
- 235000010445 lecithin Nutrition 0.000 claims description 11
- 239000011780 sodium chloride Substances 0.000 claims description 11
- 241000196324 Embryophyta Species 0.000 claims description 8
- GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 claims description 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 7
- 229960001699 ofloxacin Drugs 0.000 claims description 7
- 229920001451 polypropylene glycol Polymers 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 4
- 229940083466 soybean lecithin Drugs 0.000 claims description 4
- 244000000231 Sesamum indicum Species 0.000 claims description 3
- 235000003434 Sesamum indicum Nutrition 0.000 claims description 3
- 229910021538 borax Inorganic materials 0.000 claims description 3
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 3
- 239000004327 boric acid Substances 0.000 claims description 3
- 210000004185 liver Anatomy 0.000 claims description 3
- 239000004328 sodium tetraborate Substances 0.000 claims description 3
- 235000010339 sodium tetraborate Nutrition 0.000 claims description 3
- 235000020238 sunflower seed Nutrition 0.000 claims description 3
- 238000004090 dissolution Methods 0.000 claims description 2
- 210000002969 egg yolk Anatomy 0.000 claims description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 235000009754 Vitis X bourquina Nutrition 0.000 claims 1
- 235000012333 Vitis X labruscana Nutrition 0.000 claims 1
- 240000006365 Vitis vinifera Species 0.000 claims 1
- 235000014787 Vitis vinifera Nutrition 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 abstract description 12
- 108090000623 proteins and genes Proteins 0.000 abstract description 12
- 238000007654 immersion Methods 0.000 abstract description 4
- 238000005406 washing Methods 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- 239000003795 chemical substances by application Substances 0.000 description 8
- 238000004140 cleaning Methods 0.000 description 7
- 230000001954 sterilising effect Effects 0.000 description 7
- 238000004659 sterilization and disinfection Methods 0.000 description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- 239000008103 glucose Substances 0.000 description 6
- 230000003750 conditioning effect Effects 0.000 description 5
- 238000004807 desolvation Methods 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 4
- JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000012266 salt solution Substances 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 239000012152 bradford reagent Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 244000039328 opportunistic pathogen Species 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 238000011895 specific detection Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/34—Derivatives of acids of phosphorus
- C11D1/345—Phosphates or phosphites
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/04—Water-soluble compounds
- C11D3/046—Salts
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2006—Monohydric alcohols
- C11D3/201—Monohydric alcohols linear
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2075—Carboxylic acids-salts thereof
- C11D3/2086—Hydroxy carboxylic acids-salts thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/22—Carbohydrates or derivatives thereof
- C11D3/221—Mono, di- or trisaccharides or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/24—Organic compounds containing halogen
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/28—Heterocyclic compounds containing nitrogen in the ring
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3707—Polyethers, e.g. polyalkyleneoxides
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/39—Organic or inorganic per-compounds
- C11D3/3942—Inorganic per-compounds
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/43—Solvents
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Eyeglasses (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The invention discloses a kind of contact lens care solution, belongs to Medicines and Health Product technical field.The contact lens care solution that the present invention develops includes the raw material of following parts by weight：100~150 parts of modified phospholipid dispersion liquids, 10~15 parts of bactericide, 10~30 parts of NMFs, 3~5 parts of osmotic pressure regulators, 0.6~0.8 part of complexing agent, 80~100 parts of physiological saline；Wherein modified phospholipid dispersion liquid, which is modified, is dried up after being dissolved by phosphatide, then Freezing smashing after mix with water, is then thawed, constant temperature stirring reaction and water bath sonicator handle to obtain, wherein, phosphatide is to be compounded to form by animal phospholipids and plant phosphatide.Protein concentration is high after gained contact lens care solution immersion contact lenses of the invention, without washing by rubbing with the hands, can also wash away the proteinosis thing on contact lenses.
Description
Technical field
The invention discloses a kind of contact lens care solution, belongs to Medicines and Health Product technical field.
Background technology
The main component of contact lens care solution is sodium chloride and preservative etc., be mainly used in cleaning to biomaterial,
Sterilize, remove removing protein etc., it is undoubtedly essential for the people of contact lens wear.But some consumers' reflection is matched somebody with somebody
It is rubescent to occur eye after wearing contact lens, the adverse reaction such as do not feel like oneself.Its main cause is user in contact lens care
Caused by some mistaken ideas being present in the use of liquid.
Contact lens care solution is that contact lenses race will use daily, and the deposit of lens surface and pathogen must be first
Removed with conditioning liquid, so ensuing sterilization preservation could be carried out effectively.Because cleaning incomplete lens surface can remain
Deposit, when directly being sterilized, sterilization composition can only be combined with deposit, and can not be combined with pathogen, consequently, it is possible to kill
Bacterium composition cannot play bactericidal action.
Research finds that complete correctly cleaning mode can clean the deposit of lens surface, can also kill 90% disease
Opportunistic pathogen.But in actually using, many users simply do simple cleaning treatment, are not rubbed with hand, expert points out, this is
It is very wrong.Because with hand rub eyeglass it is most effective cleaning contact lenses most efficient method be exactly utilize " hand of oneself ",
" eyeglass cleaning solution " and " contact lenses are special, single package-type normal saline solution ".Correct method is that eyeglass is cleaned into drop
In eyeglass, directly, with finger pulp loss eyeglass is washed by rubbing with the hands back and forth.Eyeglass after washing by rubbing with the hands should be rinsed dry over and over normal saline solution
Only, eyeglass is finally moistened completely with normal saline solution again.After this whole cleaning flow is completed, ability now is sterilized.Mesh
Preceding contact lens care solution can not also just reach the effect for removing proteinosis thing by soaking, therefore also need to work out one kind
Exempt to wash contact lens care solution by rubbing with the hands.
The content of the invention
The present invention solves the technical problem of：Can not be by immersion for conventional contact lenses conditioning liquid, and need to rub with the hands
A kind of the problem of washing the proteinosis thing that can just remove on contact lenses, there is provided contact lens care solution.
In order to solve the above-mentioned technical problem, the technical solution adopted in the present invention is：
A kind of contact lens care solution, it is made up of the raw material of following parts by weight：100~150 parts of modified phospholipid dispersion liquids, 10
~15 parts of bactericide, 10~30 parts of NMFs, 3~5 parts of osmotic pressure regulators, 0.6~0.8 part of complexing agent, 80~100 parts of physiology
Salt solution；
The specific modifying process of modified phospholipid dispersion liquid is：
（1）It is 1 in mass ratio by phosphatide and solvent：10~1：After 20 mixed dissolutions, dried up with nitrogen, then remained through vacuum removal
Solvent, obtain pretreatment phosphatide；
（2）It is 1 in mass ratio that phosphatide, which will be pre-processed, with water：500~1：Freezing smashing after 600 mixing, then through thawing, must thaw
Liquid；
（3）After thawing solution constant temperature stirring reaction, water bath sonicator processing, modified phospholipid dispersion liquid is produced；
It is 10 in mass ratio by animal phospholipids and plant phosphatide that the phosphatide, which is,：1~15：1 mixes.
It by Ofloxacin and mass fraction is that 8~10% hydrogen peroxide are 1 in mass ratio that the bactericide, which is,：20~1：30 is mixed
Conjunction forms.
It is 1 in mass ratio by polyoxyethylene and polyoxypropylene that the NMF, which is,：1~1：3 mix.
The osmotic pressure regulator is any one in glucose, sodium chloride, boric acid or borax.
The complexing agent is any one in citric acid, amino carboxylic acid or 1,3- diketone.
The physiological saline is the sodium chloride solution that mass fraction is 0.9%.
Step（1）It is 1 by volume by methanol and chloroform that the solvent, which is,：1 mixes.
The animal phospholipids are any one in egg yolk lecithin or liver lecithin.
The plant phosphatide is any one in soybean lecithin, sesame lecithin or sunflower seeds lecithin.
The beneficial effects of the invention are as follows：
Technical solution of the present invention is by adding negatively charged modified phospholipid dispersion liquid, in use, contact lens surface
The protein being accompanied with tears, protein not only carried negative electrical charge again with positive charge, wherein it is negatively charged can with just
The metal ion of electric charge attracts each other, and so as to which scattered protein be connected, forms lumpy precipitate and is deposited on contact lenses
Surface, and the phospholipid molecule with negative electricity can act on metal ion positive surface charge, so as to break the company between protein
Connect, and the negative electrical charge of phospholipid surface can continue to have an effect with the positive charge of institute's band in protein, in the protein table of deposition
Face forms negative electricity layer, makes mutually exclusive between protein, and flushing can effectively remove the protein dirt of lens surface, without
Wash by rubbing with the hands, improve the wear comfort and definition of contact lenses.
Embodiment
It is 1 in mass ratio：10~1：Phosphatide is mixed and poured into beaker by 20 with solvent, with glass bar stirring and dissolving 20~
After 30min, then with nitrogen 4~5h is persistently dried up with 60~80mL/min speed, be 60~80kPa conditions with after vacuum
Under, vacuum desolvation agent handles 45~60min, obtains pretreatment phosphatide；It is 1 in mass ratio by gained pretreatment phosphatide and water：500~
1：Freezing smashing after 600 mixing, then through 5~10min of microwave thawing, thawing solution is obtained, then gained thawing solution is transferred to digital display and tested the speed
Constant temperature blender with magnetic force, in temperature be 55~60 DEG C, rotating speed be 300~500r/min under the conditions of, constant temperature 2~4h of stirring reaction,
It is again 45~50 DEG C in temperature by the thawing solution after constant temperature stirring reaction, under the conditions of supersonic frequency is 45~55kHz, water bath sonicator
Scattered 45~60min, obtains modified phospholipid dispersion liquid；Count in parts by weight, take 100~150 parts of modified phospholipid dispersion liquids successively, 10
~15 parts of bactericide, 10~30 parts of NMFs, 3~5 parts of osmotic pressure regulators, 0.6~0.8 part of complexing agent, 80~100 parts of physiology
Salt solution, 2~4h is stirred with 300~500r/min rotating speeds with mixer, obtains mixed liquor, then by gained mixed liquor ultraviolet sterilization
3~5h, produce contact lens care solution.It is 10 in mass ratio by animal phospholipids and plant phosphatide that the phosphatide, which is,：1~15：1 is mixed
Conjunction forms.The animal phospholipids are any one in egg yolk lecithin or liver lecithin.The plant phosphatide is soybean ovum
Any one in phosphatide, sesame lecithin or sunflower seeds lecithin.It by Ofloxacin and mass fraction is 8 that the bactericide, which is,
~10% hydrogen peroxide is 1 in mass ratio：20~1：30 mix.The NMF is by matter by polyoxyethylene and polyoxypropylene
Amount is than being 1：1~1：3 mix.The osmotic pressure regulator is any one in glucose, sodium chloride, boric acid or borax
Kind.The complexing agent is any one in citric acid, amino carboxylic acid or 1,3- diketone.The physiological saline is that mass fraction is
0.9% sodium chloride solution.It is 1 by volume by methanol and chloroform that the solvent, which is,：1 mixes.
Example 1
It is 1 in mass ratio：Phosphatide is mixed and poured into beaker by 20 with solvent, after glass bar stirring and dissolving 30min, then uses nitrogen
5h is persistently dried up with 80mL/min speed, under the conditions of being 80kPa after vacuum, vacuum desolvation agent processing 60min, obtains pre- place
Manage phosphatide；It is 1 in mass ratio by gained pretreatment phosphatide and water：Freezing smashing after 600 mixing, then through microwave thawing 10min, obtain
Thawing solution, then gained thawing solution is transferred to digital display and tested the speed constant temperature blender with magnetic force, it is 60 DEG C in temperature, rotating speed is 500r/min bars
Under part, constant temperature stirring reaction 4h, then by the thawing solution after constant temperature stirring reaction in temperature be 50 DEG C, supersonic frequency is 55kHz bars
Under part, water bath sonicator disperses 60min, obtains modified phospholipid dispersion liquid；Count in parts by weight, take 150 parts of modified phospholipids to disperse successively
Liquid, 15 parts of bactericide, 30 parts of NMFs, 5 parts of osmotic pressure regulators, 0.8 part of complexing agent, 100 parts of physiological saline, with mixer with
500r/min rotating speeds are stirred 4h, obtain mixed liquor, then by gained mixed liquor ultraviolet sterilization 5h, produce contact lens care solution.
It is 15 in mass ratio by animal phospholipids and plant phosphatide that the phosphatide, which is,：1 mixes.The animal phospholipids are yolk lecithin
Fat.The plant phosphatide is soybean lecithin.It by Ofloxacin and mass fraction is 10% hydrogen peroxide by quality that the bactericide, which is,
Than for 1：30 mix.It is 1 in mass ratio by polyoxyethylene and polyoxypropylene that the NMF, which is,：3 mix.It is described to ooze
Pressure conditioning agent is glucose thoroughly.The complexing agent is citric acid.The physiological saline is that the sodium chloride that mass fraction is 0.9% is molten
Liquid.It is 1 by volume by methanol and chloroform that the solvent, which is,：1 mixes.
Example 2
It is 1 in mass ratio：Phosphatide is mixed and poured into beaker by 20 with solvent, after glass bar stirring and dissolving 30min, then uses nitrogen
5h is persistently dried up with 80mL/min speed, under the conditions of being 80kPa after vacuum, vacuum desolvation agent processing 60min, obtains pre- place
Manage phosphatide；It is 1 in mass ratio by gained pretreatment phosphatide and water：Freezing smashing after 600 mixing, then through microwave thawing 10min, obtain
Thawing solution, then gained thawing solution is transferred to digital display and tested the speed constant temperature blender with magnetic force, it is 60 DEG C in temperature, rotating speed is 500r/min bars
Under part, constant temperature stirring reaction 4h, then by the thawing solution after constant temperature stirring reaction in temperature be 50 DEG C, supersonic frequency is 55kHz bars
Under part, water bath sonicator disperses 60min, obtains modified phospholipid dispersion liquid；Count in parts by weight, take 150 parts of modified phospholipids to disperse successively
Liquid, 15 parts of bactericide, 30 parts of NMFs, 5 parts of osmotic pressure regulators, 0.8 part of complexing agent, 100 parts of physiological saline, with mixer with
500r/min rotating speeds are stirred 4h, obtain mixed liquor, then by gained mixed liquor ultraviolet sterilization 5h, produce contact lens care solution.
The phosphatide is soybean lecithin.It by Ofloxacin and mass fraction is that 10% hydrogen peroxide is 1 in mass ratio that the bactericide, which is,：
30 mix.It is 1 in mass ratio by polyoxyethylene and polyoxypropylene that the NMF, which is,：3 mix.The osmotic pressure is adjusted
Section agent is glucose.The complexing agent is citric acid.The physiological saline is the sodium chloride solution that mass fraction is 0.9%.It is described
It is 1 by volume by methanol and chloroform that solvent, which is,：1 mixes.
Example 3
It is 1 in mass ratio：Phosphatide is mixed and poured into beaker by 20 with solvent, after glass bar stirring and dissolving 30min, then uses nitrogen
5h is persistently dried up with 80mL/min speed, under the conditions of being 80kPa after vacuum, vacuum desolvation agent processing 60min, obtains pre- place
Manage phosphatide；It is 1 in mass ratio by gained pretreatment phosphatide and water：Freezing smashing after 600 mixing, then through microwave thawing 10min, obtain
Thawing solution, then gained thawing solution is transferred to digital display and tested the speed constant temperature blender with magnetic force, it is 60 DEG C in temperature, rotating speed is 500r/min bars
Under part, constant temperature stirring reaction 4h, then by the thawing solution after constant temperature stirring reaction in temperature be 50 DEG C, supersonic frequency is 55kHz bars
Under part, water bath sonicator disperses 60min, obtains modified phospholipid dispersion liquid；Count in parts by weight, take 150 parts of modified phospholipids to disperse successively
Liquid, 15 parts of bactericide, 30 parts of NMFs, 5 parts of osmotic pressure regulators, 0.8 part of complexing agent, 100 parts of physiological saline, with mixer with
500r/min rotating speeds are stirred 4h, obtain mixed liquor, then by gained mixed liquor ultraviolet sterilization 5h, produce contact lens care solution.
The phosphatide is egg yolk lecithin.It by Ofloxacin and mass fraction is that 10% hydrogen peroxide is 1 in mass ratio that the bactericide, which is,：
30 mix.It is 1 in mass ratio by polyoxyethylene and polyoxypropylene that the NMF, which is,：3 mix.The osmotic pressure is adjusted
Section agent is glucose.The complexing agent is citric acid.The physiological saline is the sodium chloride solution that mass fraction is 0.9%.It is described
It is 1 by volume by methanol and chloroform that solvent, which is,：1 mixes.
Example 4
Count in parts by weight, take 15 parts of bactericide successively, 30 parts of NMFs, 5 parts of osmotic pressure regulators, 0.8 part of complexing agent, 100
Part physiological saline, 4h is stirred with mixer with 500r/min rotating speeds, obtains mixed liquor, then by gained mixed liquor ultraviolet sterilization
5h, produce contact lens care solution.It by Ofloxacin and mass fraction is that 10% hydrogen peroxide is 1 in mass ratio that the bactericide, which is,：
30 mix.It is 1 in mass ratio by polyoxyethylene and polyoxypropylene that the NMF, which is,：3 mix.The osmotic pressure is adjusted
Section agent is glucose.The complexing agent is citric acid.The physiological saline is the sodium chloride solution that mass fraction is 0.9%.It is described
It is 1 by volume by methanol and chloroform that solvent, which is,：1 mixes.
Comparative example：Certain brand contact lens care solution.
The gained of example 1 to 4 contact lens care solution and comparative example product are subjected to performance detection, specific detection method is such as
Under：
By contact lenses through above-mentioned conditioning liquid soaked overnight, without washing by rubbing with the hands, the conditioning liquid after immersion is utilized respectively Bradford
Reagent is quantitative determined.Testing result is as shown in table 1：
Table 1
| Detection content | Example 1 | Example 2 | Example 3 | Example 4 | Comparative example |
| Protein concentration mg/mL | 0.856 | 0.712 | 0.735 | 0.646 | 0.632 |
From the testing result of table 1, protein concentration is high after present invention gained contact lens care solution immersion contact lenses, without rubbing with the hands
Wash, can also wash away the proteinosis thing on contact lenses.
Claims (9)
- A kind of 1. contact lens care solution, it is characterised in that：It is made up of the raw material of following parts by weight：100~150 parts of modifications Phospholipid dispersions, 10~15 parts of bactericide, 10~30 parts of NMFs, 3~5 parts of osmotic pressure regulators, 0.6~0.8 part of complexing agent, 80~100 parts of physiological saline；The specific modifying process of modified phospholipid dispersion liquid is：（1）It is 1 in mass ratio by phosphatide and solvent：10~1：After 20 mixed dissolutions, dried up with nitrogen, then remained through vacuum removal Solvent, obtain pretreatment phosphatide；（2）It is 1 in mass ratio that phosphatide, which will be pre-processed, with water：500~1：Freezing smashing after 600 mixing, then through thawing, must thaw Liquid；（3）After thawing solution constant temperature stirring reaction, water bath sonicator processing, modified phospholipid dispersion liquid is produced；It is 10 in mass ratio by animal phospholipids and plant phosphatide that the phosphatide, which is,：1~15：1 mixes.
- A kind of 2. contact lens care solution according to claim 1, it is characterised in that：The bactericide is by Ofloxacin It is that 8~10% hydrogen peroxide are 1 in mass ratio with mass fraction：20~1：30 mix.
- A kind of 3. contact lens care solution according to claim 1, it is characterised in that：The NMF is by polyoxyethylene It is 1 in mass ratio with polyoxypropylene：1~1：3 mix.
- A kind of 4. contact lens care solution according to claim 1, it is characterised in that：The osmotic pressure regulator is grape Any one in sugar, sodium chloride, boric acid or borax.
- A kind of 5. contact lens care solution according to claim 1, it is characterised in that：The complexing agent is citric acid, ammonia Any one in yl carboxylic acid or 1,3- diketone.
- A kind of 6. contact lens care solution according to claim 1, it is characterised in that：The physiological saline is mass fraction For 0.9% sodium chloride solution.
- A kind of 7. contact lens care solution according to claim 1, it is characterised in that：Step（1）The solvent is by first Alcohol and chloroform are 1 by volume：1 mixes.
- A kind of 8. contact lens care solution according to claim 1, it is characterised in that：The animal phospholipids are yolk lecithin Any one in fat or liver lecithin.
- A kind of 9. contact lens care solution according to claim 1, it is characterised in that：The plant phosphatide is soybean lecithin Any one in fat, sesame lecithin or sunflower seeds lecithin.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110200015A (en) * | 2019-05-21 | 2019-09-06 | 何凡 | Antiviral biological peptide conditioning liquid of one kind and its preparation method and application |
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| CN1326106A (en) * | 2000-05-26 | 2001-12-12 | 盛岩 | Special nursing liquid |
| CN1390606A (en) * | 2002-06-20 | 2003-01-15 | 上海卫康光学有限公司 | Composition for treaitng contact lens and its application |
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| CN110200015A (en) * | 2019-05-21 | 2019-09-06 | 何凡 | Antiviral biological peptide conditioning liquid of one kind and its preparation method and application |
| CN110200015B (en) * | 2019-05-21 | 2020-10-30 | 乐清市泰博恒电子科技有限公司 | Antiviral biological peptide care solution and preparation method and application thereof |
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