CN1076620A - Treatment angioneurotic headache new drug ZHENNAONING JIAONANG - Google Patents
Treatment angioneurotic headache new drug ZHENNAONING JIAONANG Download PDFInfo
- Publication number
- CN1076620A CN1076620A CN92115118A CN92115118A CN1076620A CN 1076620 A CN1076620 A CN 1076620A CN 92115118 A CN92115118 A CN 92115118A CN 92115118 A CN92115118 A CN 92115118A CN 1076620 A CN1076620 A CN 1076620A
- Authority
- CN
- China
- Prior art keywords
- rhizoma
- mesh sieves
- radix
- new drug
- zhennaoning
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010019233 Headaches Diseases 0.000 title claims abstract description 9
- 231100000869 headache Toxicity 0.000 title claims abstract description 7
- 239000009284 zhennaoning Substances 0.000 title claims abstract description 7
- 239000002547 new drug Substances 0.000 title claims abstract description 5
- 241000282894 Sus scrofa domesticus Species 0.000 claims abstract description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- 241000209020 Cornus Species 0.000 claims description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 6
- 238000005202 decontamination Methods 0.000 claims description 6
- 230000003588 decontaminative effect Effects 0.000 claims description 6
- 230000007062 hydrolysis Effects 0.000 claims description 6
- 238000006460 hydrolysis reaction Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 4
- 238000012856 packing Methods 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 108091005804 Peptidases Proteins 0.000 claims description 3
- 239000004365 Protease Substances 0.000 claims description 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 3
- 235000012000 cholesterol Nutrition 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000007903 gelatin capsule Substances 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 238000001291 vacuum drying Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000003292 glue Substances 0.000 claims description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 2
- 241000282898 Sus scrofa Species 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 8
- 239000008280 blood Substances 0.000 abstract description 3
- 210000004369 blood Anatomy 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 2
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000001431 Psychomotor Agitation Diseases 0.000 abstract 1
- 206010038743 Restlessness Diseases 0.000 abstract 1
- 230000036461 convulsion Effects 0.000 abstract 1
- 208000002173 dizziness Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 208000021760 high fever Diseases 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 210000005036 nerve Anatomy 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000001407 Vascular Headaches Diseases 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
A kind of treatment angioneurotic headache new drug ZHENNAONING JIAONANG is by the Chinese medicine Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, and Medulla sus domestica, Rhizoma Gastrodiae, Herba Asaris etc. process from strand.ZHENNAONING JIAONANG is mainly passed through promoting flow of QI and blood, the suppressing the hyperactive liver cephalocathartic, and relieving restlessness is calmed the nerves, and is calm to reach the effect of the network pain that relieves dizziness, high fever, infantile convulsions, epilepsy, etc.
Description
The invention belongs to medicine and medicine manufacture field.
Headache is common clinically subjective symptoms, and it is inside and outside to be found in modern medicine, among each section's chronic disease such as neural and face, at present neural blood vessel and chronic headache is not all had good medicine and can effect a radical cure.
The objective of the invention is arteriosclerosis, hypertension and the caused nervous vascular Headache of some symptoms and chronic headache are high partially based on liver-yang, the resistance of the folder stasis of blood, the headache of two, three class diseases such as blood deficiency or expectorant are turbid is an object, develops a kind of double medicine of controlling of mark and processing technique.
The object of the present invention is achieved like this: it is by Rhizoma Chuanxiong that treatment angioneurotic headache new drug ZHENNAONING glue is assisted, Rhizoma Ligustici, and Herba Asari, the Radix Angelicae Dahuricae, Rhizoma Gastrodiae, Pulvis Cornus Bubali Concentratus, Radix Salviae Miltiorrhizae, Radix Puerariae, Medulla sus domestica constitutes.Its processing technique is pick → mixing → pulverizing → enzymolysis → mixing sterilization packing.Pick: get Rhizoma Chuanxiong, Rhizoma Ligustici, Herba Asari, the Radix Angelicae Dahuricae, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, Radix Puerariae carry out the sense organ signing, get the medical material decontamination that meets the pharmacopeia regulation, and earth is after cleaning, through low temperature＜60 ℃ drying.Mix and pulverize: get Rhizoma Chuanxiong, Rhizoma Ligustici, Herba Asari, the Radix Angelicae Dahuricae, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, dried feed such as Radix Puerariae are mixed and are pulverized, and it is standby to cross 100 mesh sieves.Get the recipe quantity Pulvis Cornus Bubali Concentratus, cross 100 mesh sieves, standby.Enzymolysis: get fresh Medulla sus domestica decontamination, clean, rub, with acetone defat cholesterol reduction, totally three times.Filtrate merging is reclaimed propanol, and filtering residue is in drying below 80 ℃, crushing fine powder.Get this fine powder with distilled water furnishing pulpous state, transfer PH to 6.5-7.0, the sad temperature of water-bath added protease hydrolysis 16 hours for 45 ℃, surveyed hydrolysis degree, and qualified back is in below 60 ℃, and vacuum drying is pulverized, and crosses 100 mesh sieves, and is standby.Said medicine mixing sterilization packing soft gelatin capsule is promptly made ZHENNAONING.
Embodiment:
Get recipe quantity Rhizoma Chuanxiong 700g, Rhizoma Ligustici 500g, Herba Asari 500g, Radix Angelicae Dahuricae 700g, Rhizoma Gastrodiae 100g, Pulvis Cornus Bubali Concentratus 100g, Radix Salviae Miltiorrhizae 700g, Radix Puerariae 700g, Medulla sus domestica 1500g, with Rhizoma Chuanxiong, Rhizoma Ligustici, Herba Asari, the Radix Angelicae Dahuricae, Rhizoma Gastrodiae, Radix Puerariae decontamination, earth is after cleaning, through low temperature＜60 ℃ drying, pulverizing is mixed in dry back, crosses 100 mesh sieves, and is standby.Get Pulvis Cornus Bubali Concentratus, cross 100 mesh sieves, standby.Get fresh Medulla sus domestica decontamination, clean, rub, with acetone defat cholesterol reduction, totally three times, filtrate merging is reclaimed acetone, and filtering residue is ground into fine powder in dry below 80 ℃.Get this fine powder with distilled water furnishing pulpous state, transfer PH to 6.5-7.0, the sad temperature of water-bath added protease hydrolysis 16 hours for 45 ℃, surveyed hydrolysis degree, and qualified back is in below 60 ℃, and vacuum drying is pulverized, and crosses 100 mesh sieves, and is standby.With said medicine mixing 100 mesh sieves of sterilizing, the packing soft gelatin capsule gets final product.
Claims (1)
- A kind of treatment angioneurotic headache new drug ZHENNAONING glue is assisted, and it is characterized in that:A, get Rhizoma Chuanxiong 500-900g.Rhizoma Ligustici 300-700g, Herba Asari 300-700g, Radix Angelicae Dahuricae 500-900g, Rhizoma Gastrodiae 50-150g, Radix Salviae Miltiorrhizae 500-900g, Radix Puerariae 500-900g, decontamination cleans after low temperature＜60 ℃ drying is mixed and pulverized 100 mesh sieves, gets Pulvis Cornus Bubali Concentratus 50-150g, cross 100 mesh sieves, get fresh Medulla sus domestica decontamination, clean and rub, with propanol defat cholesterol reduction, totally three times, filtrate merging is reclaimed acetone, filtering residue is in dry below 80 ℃, the crushed face fine powder with distilled water furnishing pulpous state, is transferred PH to 6.5-7.0 with fine powder, bath temperature added protease hydrolysis 16 hours for 45 ℃, survey hydrolysis degree, qualified back in below 60 ℃, vacuum drying, pulverize, cross 100 mesh sieves.B, with pig's brain powder, Pulvis Cornus Bubali Concentratus and Rhizoma Chuanxiong, the Rhizoma Ligustici Herba Asari, the Radix Angelicae Dahuricae, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, powder of Radix Puerariae, fully mixing is crossed 100 mesh sieves sterilization packing soft gelatin capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92115118A CN1052880C (en) | 1992-12-28 | 1992-12-28 | Preparation method of capsule for treating angioneurotic headache |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92115118A CN1052880C (en) | 1992-12-28 | 1992-12-28 | Preparation method of capsule for treating angioneurotic headache |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1076620A true CN1076620A (en) | 1993-09-29 |
| CN1052880C CN1052880C (en) | 2000-05-31 |
Family
ID=4947271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN92115118A Expired - Fee Related CN1052880C (en) | 1992-12-28 | 1992-12-28 | Preparation method of capsule for treating angioneurotic headache |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1052880C (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1051933C (en) * | 1995-04-19 | 2000-05-03 | 文渊 | Traditional Chinese medicine composition for treating refractory headache |
| WO2002022143A1 (en) * | 2000-09-12 | 2002-03-21 | Jiangsu Kanion Pharmaceutical Co. | A pharmaceutical composition for treating headache disease and process and uses thereof |
| CN1092062C (en) * | 1998-12-23 | 2002-10-09 | 侯英平 | Powder medicine for eliminating wind cold and stagnant heat |
| CN1313139C (en) * | 2005-08-31 | 2007-05-02 | 通化东宝药业股份有限公司 | Method for preparing medicine for treating angioneurotic headache |
| CN102813839A (en) * | 2012-09-11 | 2012-12-12 | 张鹏 | Compound medicine for treating cluster headache syndrome |
| CN103251819A (en) * | 2012-12-23 | 2013-08-21 | 黄天双 | Nervous headache treatment traditional Chinese medicine composition |
| CN104435778A (en) * | 2014-11-24 | 2015-03-25 | 李镇荣 | Medicine for treating facial neuralgia |
| CN105012678A (en) * | 2015-06-29 | 2015-11-04 | 祝彩云 | Traditional Chinese medicine preparation for treating angioneurotic headache |
-
1992
- 1992-12-28 CN CN92115118A patent/CN1052880C/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1051933C (en) * | 1995-04-19 | 2000-05-03 | 文渊 | Traditional Chinese medicine composition for treating refractory headache |
| CN1092062C (en) * | 1998-12-23 | 2002-10-09 | 侯英平 | Powder medicine for eliminating wind cold and stagnant heat |
| WO2002022143A1 (en) * | 2000-09-12 | 2002-03-21 | Jiangsu Kanion Pharmaceutical Co. | A pharmaceutical composition for treating headache disease and process and uses thereof |
| US6919094B1 (en) | 2000-09-12 | 2005-07-19 | Jiangsu Kanion Pharmaceutical Co., Ltd. | Composition of medicine for treating headache disease and process of preparation and uses thereof |
| CN1313139C (en) * | 2005-08-31 | 2007-05-02 | 通化东宝药业股份有限公司 | Method for preparing medicine for treating angioneurotic headache |
| CN102813839A (en) * | 2012-09-11 | 2012-12-12 | 张鹏 | Compound medicine for treating cluster headache syndrome |
| CN102813839B (en) * | 2012-09-11 | 2013-10-23 | 张鹏 | Compound medicine for treating cluster headache syndrome |
| CN103251819A (en) * | 2012-12-23 | 2013-08-21 | 黄天双 | Nervous headache treatment traditional Chinese medicine composition |
| CN104435778A (en) * | 2014-11-24 | 2015-03-25 | 李镇荣 | Medicine for treating facial neuralgia |
| CN105012678A (en) * | 2015-06-29 | 2015-11-04 | 祝彩云 | Traditional Chinese medicine preparation for treating angioneurotic headache |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1052880C (en) | 2000-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
| OR01 | Other related matters | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |