CN107569547A - A kind of ganoderma lucidum improves Chinese medicine composition of sleep and preparation method thereof - Google Patents
A kind of ganoderma lucidum improves Chinese medicine composition of sleep and preparation method thereof Download PDFInfo
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Abstract
The present invention, which discloses a kind of ganoderma lucidum, improves the Chinese medicine composition of sleep, including following components by weight：40 60 parts of ginsengs, 70 90 parts of Poria cocos, 70 90 parts of spina date seeds, 50 60 portions of fruit ofs Chinese magnoliavine and 18 22 parts of lucidum spore powders.The present invention also provides the preparation method of the Chinese medicine composition, including first extracts the ethereal oil composition in Poria cocos, spina date seed and the fruit of Chinese magnoliavine, reuses ethanol water extraction, and finally mixed with lucidum spore powder.Ganoderma lucidum provided by the invention improves the Chinese medicine composition of sleep, and a few herbs from nourishing, calming the nerves, determine many-sided harmony such as gas and set about, help to adjust human nerve maincenter, adjust the osmotic pressure of human body fluid, had a respite so as to all worries set aside, improve and sleep simultaneously.Method provided by the invention, the recovery rate of the active ingredient in each taste Chinese medicine can be effectively improved, and can preferably preserve the effective elements of the medicine in each taste, the utilization rate of pharmaceutical component is high.
Description
Technical field
Improve Chinese medicine composition of sleep and preparation method thereof the present invention relates to a kind of ganoderma lucidum, belong to Chinese medicine preparation technology neck
Domain.
Background technology
Sleep is a kind of most important form of human body rest, and human body can be regained one's strength, protected with dispelling fatigue by sleep
Brain is protected, is regained one's vigor, strengthen immunity, rehabilitation body, enhancing development, anti-aging, promotes the effect such as longevity.Insomnia
For difficulty falling asleep caused by a variety of causes, Depth of sleep or frequency be too short (shallow sleeping property insomnia), early awakening and length of one's sleep deficiency or
It is of poor quality etc., and increasingly lassitude, slow in reacting, physically weak weak, very then vexed annoyance are often accompanied by, have a strong impact on physical and mental health
And work, studying and living.Phrenoblabia is to cause principal element of having a sleepless night, and insomniac often hinders with the mood of anxiety-depression
Hinder.The insomnia incidence of China is 40% or so, developed country or city insomnia incidence more up to more than 50%.
At present, treatment insomnia mainly takes hypnotic by taking, and causes insomnia crowd to hypnotic and sedation
The dependence of antidepressant is serious all the more, but the safety issue of the antidepressant of hypnotic and sedation becomes increasingly conspicuous.
Therefore, a kind of traditional Chinese medicine health care product of good improvement sleep should meet calm the nerves calm, improvement sleeper effect and safe, nothing
The requirement such as dependence.
The content of the invention
For overcome the deficiencies in the prior art, of the invention first purpose, which is to provide one kind, to have no side effect, nothing
The ganoderma lucidum of dependence improves the Chinese medicine composition of sleep.
Second object of the present invention is to provide for the preparation method of above-mentioned Chinese medicine composition.
Realizing first purpose of the present invention can be reached by adopting the following technical scheme that：
A kind of ganoderma lucidum improves the Chinese medicine composition of sleep, including following components by weight：40-60 parts ginseng, 70-
90 parts of Poria cocos, 70-90 parts spina date seed, 50-60 parts fruit of Chinese magnoliavine and 18-22 part lucidum spore powders.
Further, including by weight following components：45-55 parts ginseng, 75-85 parts Poria cocos, 75-85 part wild jujubes
Benevolence, 53-57 parts fruit of Chinese magnoliavine and 18-22 part lucidum spore powders.
Further, including by weight following components：50 parts of ginsengs, 80 parts of Poria cocos, 80 parts of spina date seeds, 55 part five
Taste and 20 parts of lucidum spore powders.
Further, in addition to auxiliary material.
Further, the auxiliary material is honey or lactose or white sugar or CMC- sodium.
Realize that second object of the present invention can reach by adopting the following technical scheme that：
Preparing above-mentioned ganoderma lucidum improves the method for Chinese medicine composition of sleep, comprises the following steps：
1) Poria cocos, spina date seed and the fruit of Chinese magnoliavine are taken, it is 80-100 targeted fine powders to be ground into particle diameter；
2) water of 10-15 times of volume is added in the fine powder obtained to step 1), adds the volume of n-hexane, n-hexane and water
Than for 1:80-100, stir, heating decompression infusion 4-8h, collect cut, isolate oil phase；
3) isometric ethanol is added in the infusion liquid to step 2), ginseng normal pressure infusion 4-8h is added, filtering, is filtered
Liquid, vacuum distillation remove solvent, obtain medicinal extract；
4) combining step 2) oil phase and the obtained medicinal extract of step 3), lucidum spore powder, be mixed, dry, obtain Chinese medicine group
Compound.
Further, in step 2), the pressure for depressurizing infusion is 5-15KPa, and decompression infusion temperature is 60-80 DEG C.
Further, after step 4), in addition to step 5) adds auxiliary material and pelletized.
Further, the auxiliary material is honey or lactose or white sugar or CMC- sodium.
The formulation Design Principle of the present invention is as follows：
The Main Ingredients and Appearance of this product is glossy ganoderma spore powder with crushed sporoderm, ginseng, Poria cocos, spina date seed.Glossy ganoderma spore powder with crushed sporoderm contains more
Carbohydrate, polypeptide, amino acids, triterpenes, alkaloids, inorganic salts etc., Central nervous system have adjustment effect, have it is stable,
Calm, analgesic function, had a sleepless night for neurasthenia and caused by nervous, fatigue, be dizzy, weak, nervous etc.
Symptom improves significantly effect, while can improve function of both cellular immunity and humoral immunity, so as to strengthen body
To the resistivity of various diseases.
Ginseng main component is panaxoside, panaxan, Radix Ginseng protein, ginseng essential oil, amino acid, inorganic member
Element, peptide matters, multivitamin, alkaloid etc., major function have regulation central nervous system, improve the excitement and suppression of brain
Process processed, it is allowed to tend to balance, it is antifatigue, strengthen myocardial contractive power, reducing heart rate can resist myocardial ischemia and arrhythmia cordis, increase
The functions such as strong immunity of organisms.
Poria cocos main component is pachyman, triterpene compound, pachymic acid etc., has mental-tranquilization effect, is usually used in
The diseases such as confused and worried, palpitaition, insomnia, often with the compatibility such as ginseng, polygala, spina date seed.
Spina date seed main component is jujuboside, betulic acid, betulin, alkaloid, several amino acids etc., can be played
Antitoxic heart-soothing and sedative, calmness, hypnosis, bowl spares nourishing the liver, etc. effect.The effect of four kinds of Chinese herbal medicines of the above interaction between component, give full play to
The medicinal effects of this product, have adjustment effect to human central nervous system to reach, it is stable allay excitement, be calm, calm nerves are nervous,
Antifatigue, raising immunity of organisms, so as to improve sleep quality and other effects.
The fruit of Chinese magnoliavine is nourishing Chinese medicine, is considered to have QI invigorating strong the moon, improving eyesight, strengthens the bone, supports the five internal organs and other effects.This formula
In, the volatile oil of the fruit of Chinese magnoliavine and lignanoid, the immunity and fatigue resistance of body on the basis of fostering the spirit of nobility and calming the nerves, can be improved.
Compared with prior art, the beneficial effects of the present invention are：
Ganoderma lucidum provided by the invention improves the Chinese medicine composition of sleep, a few herbs simultaneously from nourish, calm the nerves, to determine gas etc. more
Aspect harmony is set about, and is helped to adjust human nerve maincenter, is adjusted the osmotic pressure of human body fluid, has a respite, improve so as to all worries set aside
Sleep.Method provided by the invention, can effectively improve the recovery rate of the active ingredient in each taste Chinese medicine, and can preferably preserve
The effective elements of the medicine in each taste, the utilization rate of pharmaceutical component are high.
Embodiment
Below, with reference to embodiment, the present invention is described further：
In detailed description below, such as non-specified otherwise, used traditional Chinese medicinal components or auxiliary material can pass through routine
Research technique or commercially available approach obtain.
A kind of ganoderma lucidum improves the Chinese medicine composition of sleep, it is characterised in that including following components by weight：40-
60 parts of ginsengs, 70-90 parts Poria cocos, 70-90 parts spina date seed, 50-60 parts fruit of Chinese magnoliavine and 18-22 part lucidum spore powders.
Preparing the ganoderma lucidum improves the method for Chinese medicine composition of sleep, comprises the following steps：
1) Poria cocos, spina date seed and the fruit of Chinese magnoliavine are taken, it is 80-100 targeted fine powders to be ground into particle diameter；
2) water of 10-15 times of volume is added in the fine powder obtained to step 1), adds the volume of n-hexane, n-hexane and water
Than for 1:80-100, stir, heating decompression infusion 4-8h, collect cut, isolate oil phase；
3) isometric ethanol is added in the infusion liquid to step 2), ginseng normal pressure infusion 4-8h is added, filtering, is filtered
Liquid, vacuum distillation remove solvent, obtain medicinal extract；
4) combining step 2) oil phase and the obtained medicinal extract of step 3), lucidum spore powder, be mixed, dry, obtain Chinese medicine group
Compound.
Ganoderma lucidum provided by the invention improves the Chinese medicine composition of sleep, a few herbs simultaneously from nourish, calm the nerves, to determine gas etc. more
Aspect harmony is set about, and is helped to adjust human nerve maincenter, is adjusted the osmotic pressure of human body fluid, has a respite, improve so as to all worries set aside
Sleep.Method provided by the invention, can effectively improve the recovery rate of the active ingredient in each taste Chinese medicine, and can preferably preserve
The effective elements of the medicine in each taste, the utilization rate of pharmaceutical component are high.
Embodiment 1：
A kind of ganoderma lucidum improves the Chinese medicine composition of sleep, it is characterised in that including following components by weight：50 parts
Ginseng, 80 parts of Poria cocos, 80 parts of spina date seeds, 55 portions of fruit ofs Chinese magnoliavine and 20 parts of lucidum spore powders.
Preparing the ganoderma lucidum improves the method for Chinese medicine composition of sleep, comprises the following steps：
1) Poria cocos, spina date seed and the fruit of Chinese magnoliavine are taken, it is 80-100 targeted fine powders to be ground into particle diameter；
2) water of 13 times of volumes is added in the fine powder obtained to step 1), adds the volume ratio of n-hexane, n-hexane and water
For 1:90, stir, in the lower 70 DEG C of decompressions infusion 6h of 5-15KPa pressure, collect cut, isolate oil phase；
3) isometric ethanol is added in the infusion liquid to step 2), ginseng normal pressure infusion 6h is added, filtering, is filtered
Liquid, vacuum distillation remove solvent, obtain medicinal extract；
4) combining step 2) oil phase and the obtained medicinal extract of step 3), lucidum spore powder, be mixed, dry, obtain Chinese medicine group
Compound.
Embodiment 2：
A kind of ganoderma lucidum improves the Chinese medicine composition of sleep, it is characterised in that including following components by weight：40 parts
Ginseng, 70 parts of Poria cocos, 90 parts of spina date seeds, 50 portions of fruit ofs Chinese magnoliavine and 18 parts of lucidum spore powders.
Preparing the ganoderma lucidum improves the method for Chinese medicine composition of sleep, comprises the following steps：
1) Poria cocos, spina date seed and the fruit of Chinese magnoliavine are taken, it is 80-100 targeted fine powders to be ground into particle diameter；
2) water of 10 times of volumes is added in the fine powder obtained to step 1), adds the volume ratio of n-hexane, n-hexane and water
For 1:100, stir, in the lower 80 DEG C of decompressions infusion 2h of 5-15KPa pressure, collect cut, isolate oil phase；
3) isometric ethanol is added in the infusion liquid to step 2), ginseng normal pressure infusion 4h is added, filtering, is filtered
Liquid, vacuum distillation remove solvent, obtain medicinal extract；
4) combining step 2) oil phase and the obtained medicinal extract of step 3), lucidum spore powder, be mixed, dry, obtain Chinese medicine group
Compound.
Embodiment 3：
A kind of ganoderma lucidum improves the Chinese medicine composition of sleep, it is characterised in that including following components by weight：60 parts
Ginseng, 90 parts of Poria cocos, 70 parts of spina date seeds, 60 portions of fruit ofs Chinese magnoliavine and 22 parts of lucidum spore powders.
Preparing the ganoderma lucidum improves the method for Chinese medicine composition of sleep, comprises the following steps：
1) Poria cocos, spina date seed and the fruit of Chinese magnoliavine are taken, it is 80-100 targeted fine powders to be ground into particle diameter；
2) water of 10 times of volumes is added in the fine powder obtained to step 1), adds the volume ratio of n-hexane, n-hexane and water
For 1:100, stir, in the lower 60 DEG C of decompressions infusion 6h of 5-15KPa pressure, collect cut, isolate oil phase；
3) isometric ethanol is added in the infusion liquid to step 2), ginseng normal pressure infusion 4h is added, filtering, is filtered
Liquid, vacuum distillation remove solvent, obtain medicinal extract；
4) combining step 2) oil phase and the obtained medicinal extract of step 3), lucidum spore powder, be mixed, dry, obtain Chinese medicine group
Compound.
The Chinese medicine composition as made from embodiment 1-3, further auxiliary material can be added to be granulation into preparation, auxiliary material and Chinese traditional medicine composition
The weight ratio of thing is 1:1-2.The agent that recommends of this Chinese medicine composition is 0.01g/kg.bw/day.
Efficacy test and effect assessment
40 volunteers have been collected at this center, are divided into 4 groups, and the Chinese medicine composition for taking the present embodiment 1 to obtain, collator refuses to obey
With basic, normal, high dosage group presses 0.01g/kg.bw/day, 0.02g/kg.bw/day and 0.05g/kg.bw/day dosage respectively
Taken, volunteer and testing crew are operated using double blinding.Curative effect is carried out with Pittsburgh Sleep Quality Index (PSQI)
Evaluation, it is as a result as shown in the table：
| Group | Average PSQI |
| Low dosage | 18.8 |
| Middle dosage | 19.4 |
| High dose | 19.3 |
| Control group | 16.9 |
As seen from the above table, after taking the Chinese medicine composition that ganoderma lucidum provided by the invention improves sleep, the sleep matter of volunteer
Amount significantly improves.
For those skilled in the art, technical scheme that can be as described above and design, make other each
Kind is corresponding to be changed and deforms, and all these change and deformed the protection model that should all belong to the claims in the present invention
Within enclosing.
Claims (9)
1. a kind of ganoderma lucidum improves the Chinese medicine composition of sleep, it is characterised in that including following components by weight：40-60
Part ginseng, 70-90 parts Poria cocos, 70-90 parts spina date seed, 50-60 parts fruit of Chinese magnoliavine and 18-22 part lucidum spore powders.
2. ganoderma lucidum according to claim 1 improves the Chinese medicine composition of sleep, it is characterised in that including by weight
Following components：45-55 parts ginseng, 75-85 parts Poria cocos, 75-85 parts spina date seed, 53-57 parts fruit of Chinese magnoliavine and 18-22 part Reishi sporules
Powder.
3. ganoderma lucidum according to claim 1 improves the Chinese medicine composition of sleep, it is characterised in that including by weight
Following components：50 parts of ginsengs, 80 parts of Poria cocos, 80 parts of spina date seeds, 55 portions of fruit ofs Chinese magnoliavine and 20 parts of lucidum spore powders.
4. ganoderma lucidum according to claim 1 improves the Chinese medicine composition of sleep, it is characterised in that also including auxiliary material.
5. ganoderma lucidum according to claim 4 improves the Chinese medicine composition of sleep, it is characterised in that the auxiliary material be honey or
Lactose or white sugar or CMC- sodium.
6. a kind of method that ganoderma lucidum prepared as described in claim any one of 1-5 improves the Chinese medicine composition of sleep, including with
Lower step：
1) Poria cocos, spina date seed and the fruit of Chinese magnoliavine are taken, it is 80-100 targeted fine powders to be ground into particle diameter；
2) water of 10-15 times of volume is added in the fine powder obtained to step 1), adds n-hexane, the volume ratio of n-hexane and water is
1:80-100, stir, heating decompression infusion 4-8h, collect cut, isolate oil phase；
3) isometric ethanol is added in the infusion liquid to step 2), ginseng normal pressure infusion 4-8h is added, filtering, obtains filtrate,
Solvent is removed in vacuum distillation, obtains medicinal extract；
4) combining step 2) oil phase and the obtained medicinal extract of step 3), lucidum spore powder, be mixed, dry, obtain Chinese medicine composition.
7. according to the method for claim 6, it is characterised in that in step 2), the pressure for depressurizing infusion is 5-15KPa, is subtracted
It is 60-80 DEG C to press infusion temperature.
8. according to the method for claim 6, it is characterised in that after step 4), in addition to step 5) adds auxiliary material and carried out
Granulation.
9. according to the method for claim 8, it is characterised in that the auxiliary material is honey or lactose or white sugar or CMC- sodium.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108653415A (en) * | 2018-06-27 | 2018-10-16 | 福建农林大学 | A kind of composition and preparation method thereof with sedative action |
| CN115590932A (en) * | 2022-10-10 | 2023-01-13 | 韩封三祝（Cn） | A traditional Chinese medicine composition for treating insomnia, dreaminess and easy wakefulness |
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| US6416795B1 (en) * | 2000-09-20 | 2002-07-09 | Byung Hak Choi | Herbal extract composition for stress prevention and treatment |
| CN102488212A (en) * | 2011-12-29 | 2012-06-13 | 山东省医药工业研究所 | Health food used for improving sleep, and preparation method thereof |
| CN103202478A (en) * | 2013-05-03 | 2013-07-17 | 高益槐 | Health protection food for improving sleepy quality and preparation method thereof |
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| US6416795B1 (en) * | 2000-09-20 | 2002-07-09 | Byung Hak Choi | Herbal extract composition for stress prevention and treatment |
| CN102488212A (en) * | 2011-12-29 | 2012-06-13 | 山东省医药工业研究所 | Health food used for improving sleep, and preparation method thereof |
| CN103202478A (en) * | 2013-05-03 | 2013-07-17 | 高益槐 | Health protection food for improving sleepy quality and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108653415A (en) * | 2018-06-27 | 2018-10-16 | 福建农林大学 | A kind of composition and preparation method thereof with sedative action |
| CN108653415B (en) * | 2018-06-27 | 2021-03-02 | 福建农林大学 | A kind of composition with sedative effect and preparation method thereof |
| CN115590932A (en) * | 2022-10-10 | 2023-01-13 | 韩封三祝（Cn） | A traditional Chinese medicine composition for treating insomnia, dreaminess and easy wakefulness |
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